psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V60	R:R:Y119	5.05	No	Yes	0	5	4
2	R:R:I62	R:R:Y119	7.25	No	Yes	0	5	4
3	R:R:T63	R:R:Y119	4.99	No	Yes	0	5	4
4	R:R:L120	R:R:T63	10.32	No	No	0	4	5
5	R:R:S116	R:R:Y66	5.09	No	No	0	6	6
6	R:R:Y313	R:R:Y66	6.95	Yes	No	0	4	6
7	R:R:A317	R:R:Y66	5.34	No	No	0	5	6
8	R:R:T321	R:R:V69	4.76	No	No	0	5	7
9	R:R:S324	R:R:V69	6.46	No	No	0	7	7
10	R:R:F70	R:R:V71	3.93	Yes	No	0	7	5
11	R:R:F70	R:R:L74	7.31	Yes	No	0	7	6
12	R:R:F70	R:R:M112	4.98	Yes	No	0	7	7
13	R:R:D105	R:R:N77	6.73	Yes	No	0	9	9
14	R:R:A106	R:R:N77	4.69	No	No	0	8	9
15	R:R:N77	R:R:P327	13.03	No	No	0	9	9
16	R:R:F82	R:R:L79	4.87	No	No	0	4	6
17	R:R:A102	R:R:V80	5.09	No	No	0	8	9
18	R:R:A331	R:R:V80	3.39	No	No	0	7	9
19	R:R:T88	R:R:V83	6.35	No	No	1	6	8
20	R:R:F337	R:R:V83	14.42	Yes	No	1	8	8
21	R:R:I84	R:R:M90	4.37	No	No	0	7	7
22	R:R:F99	R:R:I84	3.77	No	No	0	5	7
23	R:R:R86	R:R:Y87	9.26	No	No	0	5	5
24	R:R:N95	R:R:T88	5.85	No	No	1	7	6
25	R:R:F337	R:R:T88	11.67	Yes	No	1	8	6
26	R:R:I96	R:R:M90	4.37	No	No	0	5	7
27	R:R:T92	R:R:T94	4.71	No	No	0	7	8
28	R:R:N95	R:R:T92	5.85	No	No	0	7	7
29	R:R:A93	R:R:Y97	5.34	No	Yes	0	6	7
30	R:R:F337	R:R:N95	4.83	Yes	No	1	8	7
31	R:R:I96	R:R:N179	4.25	No	Yes	0	5	7
32	R:R:M151	R:R:Y97	13.17	Yes	Yes	1	6	7
33	R:R:M152	R:R:Y97	4.79	No	Yes	1	8	7
34	R:R:D155	R:R:Y97	8.05	No	Yes	0	8	7
35	R:R:A175	R:R:Y97	4	No	Yes	0	7	7
36	R:R:N179	R:R:Y97	3.49	Yes	Yes	1	7	7
37	R:R:I98	R:R:M152	4.37	No	No	1	8	8
38	R:R:I98	R:R:Y330	3.63	No	Yes	1	8	9
39	R:R:F337	R:R:I98	3.77	Yes	No	1	8	8
40	R:R:F99	R:R:N100	4.83	No	No	0	5	9
41	R:R:N100	R:R:N179	14.98	No	Yes	0	9	7
42	R:R:N100	R:R:W183	5.65	No	No	0	9	9
43	R:R:D105	R:R:L101	5.43	Yes	Yes	1	9	9
44	R:R:L101	R:R:T148	4.42	Yes	No	0	9	7
45	R:R:L101	R:R:N326	6.87	Yes	Yes	1	9	9
46	R:R:L101	R:R:Y330	3.52	Yes	Yes	1	9	9
47	R:R:D105	R:R:S145	5.89	Yes	No	0	9	9
48	R:R:D105	R:R:S323	8.83	Yes	No	0	9	8
49	R:R:D105	R:R:N326	10.77	Yes	Yes	1	9	9
50	R:R:L107	R:R:N141	13.73	No	No	0	6	8
51	R:R:S323	R:R:V108	6.46	No	No	0	8	7
52	R:R:M112	R:R:Y320	17.96	No	Yes	0	7	6
53	R:R:F114	R:R:F126	7.5	No	Yes	0	5	7
54	R:R:F114	R:R:V134	6.55	No	No	0	5	6
55	R:R:Q115	R:R:Y313	3.38	No	Yes	0	7	4
56	R:R:Q115	R:R:Y320	11.27	No	Yes	2	7	6
57	L:L:?1	R:R:Q115	10.35	Yes	No	2	0	7
58	R:R:F126	R:R:T117	6.49	Yes	No	0	7	4
59	R:R:V118	R:R:Y313	5.05	No	Yes	0	5	4
60	R:R:Y119	R:R:Y313	12.91	Yes	Yes	0	4	4
61	R:R:M121	R:R:S123	4.6	No	No	0	4	4
62	R:R:M121	R:R:P125	6.71	No	No	0	4	1
63	R:R:N122	R:R:V207	4.43	No	No	0	5	3
64	R:R:I208	R:R:S123	6.19	No	No	0	4	4
65	R:R:F126	R:R:W124	18.04	Yes	Yes	0	7	8
66	R:R:C131	R:R:W124	9.14	No	Yes	3	9	8
67	R:R:C210	R:R:W124	22.2	No	Yes	3	9	8
68	R:R:F126	R:R:P125	5.78	Yes	No	0	7	1
69	R:R:F126	R:R:L130	3.65	Yes	No	0	7	5
70	R:R:D128	R:R:K132	13.83	No	No	0	2	6
71	R:R:D128	R:R:T199	8.67	No	No	0	2	4
72	R:R:C131	R:R:T199	3.38	No	No	0	9	4
73	R:R:C131	R:R:C210	7.28	No	No	3	9	9
74	R:R:G198	R:R:K132	5.23	No	No	0	4	6
75	L:L:?1	R:R:V134	4.63	Yes	No	0	0	6
76	R:R:L135	R:R:L212	5.54	No	No	0	4	4
77	L:L:?1	R:R:L135	13.99	Yes	No	0	0	4
78	R:R:A193	R:R:S136	3.42	No	No	0	5	5
79	R:R:I194	R:R:S136	7.74	No	No	0	4	5
80	R:R:I137	R:R:N141	4.25	No	No	0	5	8
81	L:L:?1	R:R:D138	17.94	Yes	No	0	0	6
82	R:R:L212	R:R:Y139	3.52	No	No	0	4	5
83	R:R:M226	R:R:Y139	3.59	No	No	0	5	5
84	L:L:?1	R:R:Y139	6.38	Yes	No	0	0	5
85	R:R:N141	R:R:Y140	3.49	No	No	0	8	5
86	R:R:W183	R:R:Y140	11.58	No	No	0	9	5
87	R:R:F143	R:R:M142	4.98	Yes	No	0	6	7
88	R:R:M142	R:R:W287	5.82	No	Yes	2	7	8
89	L:L:?1	R:R:M142	5.5	Yes	No	2	0	7
90	R:R:F143	R:R:V189	9.18	Yes	No	0	6	5
91	R:R:F143	R:R:V230	5.24	Yes	No	0	6	5
92	R:R:A234	R:R:F143	4.16	No	Yes	0	6	6
93	R:R:T144	R:R:W183	14.55	No	No	0	7	9
94	R:R:F147	R:R:I146	3.77	No	No	0	6	7
95	R:R:I146	R:R:P238	3.39	No	No	0	7	9
96	R:R:F283	R:R:I146	3.77	No	No	0	9	7
97	R:R:F147	R:R:I182	8.79	No	No	0	6	7
98	R:R:L149	R:R:N326	5.49	No	Yes	0	8	9
99	R:R:L149	R:R:Y330	4.69	No	Yes	0	8	9
100	R:R:P238	R:R:T150	5.25	No	No	0	9	7
101	R:R:I241	R:R:T150	4.56	No	No	0	6	7
102	R:R:I178	R:R:M151	4.37	No	Yes	0	6	6
103	R:R:M151	R:R:N179	4.21	Yes	Yes	1	6	7
104	R:R:I182	R:R:M151	4.37	No	Yes	0	7	6
105	R:R:M152	R:R:Y330	5.99	No	Yes	1	8	9
106	R:R:I242	R:R:S153	6.19	No	No	0	8	9
107	R:R:C245	R:R:S153	3.44	No	No	0	7	9
108	R:R:S153	R:R:Y246	6.36	No	No	0	9	8
109	R:R:D155	R:R:R170	11.91	No	No	0	8	6
110	R:R:R156	R:R:Y246	9.26	No	No	0	9	8
111	R:R:R156	R:R:Y330	10.29	No	Yes	0	9	9
112	R:R:C161	R:R:Y157	9.41	No	Yes	4	7	7
113	R:R:H162	R:R:Y157	8.71	No	Yes	4	6	7
114	R:R:C245	R:R:Y157	6.72	No	Yes	0	7	7
115	R:R:L248	R:R:Y157	7.03	No	Yes	0	4	7
116	R:R:F169	R:R:I158	5.02	No	No	0	4	5
117	R:R:A159	R:R:R170	6.91	No	No	0	8	6
118	R:R:M249	R:R:V160	7.61	No	No	0	8	8
119	R:R:L253	R:R:V160	5.96	Yes	No	0	8	8
120	R:R:C161	R:R:H162	4.42	No	No	4	7	6
121	R:R:F169	R:R:K174	4.96	No	No	0	4	5
122	R:R:F169	R:R:I178	3.77	No	No	0	4	6
123	R:R:P172	R:R:T171	3.5	No	No	0	2	7
124	R:R:K174	R:R:T171	4.5	No	No	0	5	7
125	R:R:I177	R:R:L173	4.28	No	No	0	3	4
126	R:R:F214	R:R:L196	3.65	No	No	0	6	4
127	R:R:G197	R:R:L212	3.42	No	No	0	4	4
128	R:R:K200	R:R:Q213	10.85	No	No	0	2	4
129	R:R:D216	R:R:K200	5.53	No	No	0	2	2
130	R:R:R202	R:R:V207	7.85	No	No	0	2	3
131	R:R:E209	R:R:R202	10.47	No	No	0	3	2
132	R:R:H304	R:R:R202	10.16	No	No	0	1	2
133	R:R:Q213	R:R:S211	4.33	No	No	0	4	4
134	R:R:D223	R:R:F214	9.55	No	No	0	4	6
135	R:R:D216	R:R:S220	4.42	No	No	0	2	2
136	R:R:D217	R:R:D218	3.99	No	No	0	1	4
137	R:R:W221	R:R:Y219	3.86	No	No	0	1	1
138	R:R:W221	R:R:W222	19.68	No	No	0	1	7
139	R:R:D223	R:R:K227	6.91	No	No	0	4	4
140	R:R:C229	R:R:F225	5.59	No	No	0	3	4
141	R:R:I294	R:R:K227	8.72	No	No	0	5	4
142	R:R:F231	R:R:F235	6.43	Yes	Yes	2	5	8
143	R:R:F231	R:R:V236	3.93	Yes	No	0	5	4
144	R:R:F231	R:R:H291	5.66	Yes	Yes	2	5	8
145	R:R:F231	R:R:L295	3.65	Yes	No	0	5	5
146	R:R:F233	R:R:I232	6.28	No	No	0	4	5
147	R:R:F235	R:R:V239	3.93	Yes	No	0	8	6
148	R:R:F235	R:R:T288	5.19	Yes	No	0	8	5
149	R:R:F235	R:R:H291	7.92	Yes	Yes	2	8	8
150	R:R:I237	R:R:P238	3.39	No	No	0	5	9
151	R:R:V276	R:R:Y246	10.09	No	No	0	8	8
152	R:R:I250	R:R:T273	6.08	No	No	0	5	6
153	R:R:L253	R:R:L259	5.54	Yes	Yes	5	8	3
154	R:R:L259	R:R:L269	4.15	Yes	Yes	0	3	6
155	R:R:L269	R:R:S260	4.5	Yes	No	0	6	4
156	R:R:G261	R:R:S262	3.71	No	No	0	3	1
157	R:R:G261	R:R:K265	3.49	No	No	0	3	4
158	R:R:E264	R:R:N268	9.2	No	No	0	3	5
159	R:R:N268	R:R:R271	10.85	No	No	0	5	7
160	R:R:E335	R:R:R271	9.3	No	No	0	4	7
161	R:R:L329	R:R:V279	4.47	Yes	No	1	8	8
162	R:R:V279	R:R:Y330	6.31	No	Yes	1	8	9
163	R:R:F283	R:R:W287	5.01	No	Yes	0	9	8
164	R:R:C286	R:R:N322	4.72	No	No	0	8	9
165	R:R:H291	R:R:W287	5.29	Yes	Yes	2	8	8
166	R:R:N322	R:R:W287	14.69	No	Yes	0	9	8
167	L:L:?1	R:R:W287	4.43	Yes	Yes	2	0	8
168	R:R:P289	R:R:T288	3.5	No	No	0	9	5
169	R:R:I290	R:R:I294	4.42	No	No	0	6	5
170	L:L:?1	R:R:H291	4	Yes	Yes	2	0	8
171	R:R:F293	R:R:S311	7.93	No	No	0	5	4
172	R:R:F293	R:R:Y312	7.22	No	No	0	5	4
173	L:L:?1	R:R:I294	8.88	Yes	No	0	0	5
174	R:R:L309	R:R:Y313	4.69	No	Yes	0	4	4
175	R:R:I316	R:R:Y312	10.88	No	No	2	5	4
176	L:L:?1	R:R:Y312	9.12	Yes	No	2	0	4
177	R:R:I316	R:R:Y320	3.63	No	Yes	2	5	6
178	L:L:?1	R:R:I316	6.66	Yes	No	2	0	5
179	L:L:?1	R:R:Y320	10.03	Yes	Yes	2	0	6
180	R:R:N322	R:R:N326	6.81	No	Yes	0	9	9
181	R:R:L325	R:R:S324	6.01	No	No	0	6	7
182	R:R:I328	R:R:L325	5.71	No	No	0	7	6
183	R:R:L329	R:R:Y330	3.52	Yes	Yes	1	8	9
184	R:R:D334	R:R:N336	4.04	No	No	0	8	6
185	R:R:D334	R:R:F337	5.97	No	Yes	0	8	8
186	R:R:E335	R:R:K338	5.4	No	No	0	4	8
187	R:R:E335	R:R:R339	5.82	No	No	0	4	5
188	R:R:A104	R:R:T144	3.36	No	No	0	8	7
189	R:R:C315	R:R:I290	3.27	No	No	0	7	6
190	R:R:S188	R:R:V189	3.23	No	No	0	4	5
191	R:R:S301	R:R:V296	3.23	No	No	0	2	4
192	R:R:D217	R:R:P215	3.22	No	No	0	1	5
193	R:R:V239	R:R:V284	3.21	No	No	0	6	6
194	R:R:S323	R:R:T109	3.2	No	No	0	8	6
195	R:R:S186	R:R:T144	3.2	No	No	0	8	7
196	R:R:R267	R:R:R274	3.2	No	No	0	4	6
197	R:R:I58	R:R:V60	3.07	No	No	0	4	5
198	R:R:I158	R:R:V154	3.07	No	No	0	5	6
199	R:R:I232	R:R:V236	3.07	No	No	0	5	4
200	R:R:I242	R:R:V280	3.07	No	No	0	8	8
201	R:R:I243	R:R:V280	3.07	No	No	0	5	8
202	R:R:F225	R:R:W221	3.01	No	No	0	4	1
203	R:R:L196	R:R:V195	2.98	No	No	0	4	4
204	R:R:L329	R:R:V282	2.98	Yes	No	0	8	7
205	R:R:I133	R:R:I137	2.94	No	No	0	5	5
206	R:R:D266	R:R:S260	2.94	No	No	0	3	4
207	R:R:I84	R:R:M81	2.92	No	No	0	7	7
208	R:R:D206	R:R:V207	2.92	No	No	0	3	3
209	R:R:I96	R:R:K176	2.91	No	No	0	5	4
210	R:R:F70	R:R:P113	2.89	Yes	No	0	7	8
211	R:R:D138	R:R:T111	2.89	No	No	0	6	7
212	R:R:I272	R:R:L253	2.85	No	Yes	5	7	8
213	R:R:I272	R:R:L259	2.85	No	Yes	5	7	3
214	R:R:K254	R:R:L269	2.82	No	Yes	0	4	6
215	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
216	R:R:C161	R:R:R252	2.79	No	No	0	7	5
217	R:R:L103	R:R:L107	2.77	No	No	0	6	6
218	R:R:A166	R:R:R170	2.77	No	No	0	5	6
219	R:R:A331	R:R:F337	2.77	No	Yes	0	7	8
220	R:R:R252	R:R:S255	2.64	No	No	0	5	4
221	R:R:R252	R:R:V160	2.62	No	No	0	5	8
222	R:R:S187	R:R:Y140	2.54	No	No	0	4	5
223	R:R:V83	R:R:Y87	2.52	No	No	0	8	5
224	R:R:D218	R:R:Y219	2.3	No	No	0	4	1
225	R:R:F82	R:R:R86	2.14	No	No	0	4	5
226	R:R:R267	R:R:R270	2.13	No	No	0	4	5
227	R:R:F214	R:R:W222	2	No	No	0	6	7
228	R:R:G190	R:R:S136	1.86	No	No	0	6	5
229	R:R:G300	R:R:S301	1.86	No	No	0	2	2
230	R:R:G76	R:R:V75	1.84	No	No	0	7	4
231	R:R:G190	R:R:V189	1.84	No	No	0	6	5
232	R:R:G73	R:R:T109	1.82	No	No	0	8	6
233	R:R:G300	R:R:L299	1.71	No	No	0	2	4
234	R:R:A307	R:R:S305	1.71	No	No	0	4	3
235	R:R:A307	R:R:S310	1.71	No	No	0	4	2
236	R:R:A317	R:R:V65	1.7	No	No	0	5	5
237	R:R:I58	R:R:P59	1.69	No	No	0	4	4
238	R:R:A308	R:R:T302	1.68	No	No	0	3	1
239	R:R:G198	R:R:Q213	1.64	No	No	0	4	4
240	R:R:L318	R:R:P289	1.64	No	No	0	8	9
241	R:R:S324	R:R:V72	1.62	No	No	0	7	5
242	R:R:A298	R:R:K227	1.61	No	No	0	4	4
243	R:R:S301	R:R:T302	1.6	No	No	0	2	1
244	R:R:A298	R:R:L224	1.58	No	No	0	4	3
245	R:R:I133	R:R:V129	1.54	No	No	0	5	1
246	R:R:I191	R:R:V195	1.54	No	No	0	4	4
247	R:R:H162	R:R:P163	1.53	No	No	0	6	8
248	R:R:M112	R:R:V69	1.52	No	No	0	7	7
249	R:R:I243	R:R:T247	1.52	No	No	0	5	4
250	R:R:I292	R:R:T288	1.52	No	No	0	5	5
251	R:R:L184	R:R:S187	1.5	No	No	0	4	4
252	R:R:L196	R:R:S192	1.5	No	No	0	4	7
253	R:R:L240	R:R:V236	1.49	No	No	0	3	4
254	R:R:L253	R:R:V256	1.49	Yes	No	0	8	6
255	R:R:L258	R:R:V256	1.49	No	No	0	5	6
256	R:R:L275	R:R:V279	1.49	No	No	0	8	8
257	R:R:L277	R:R:V276	1.49	No	No	0	4	8
258	R:R:I228	R:R:I232	1.47	No	No	0	5	5
259	R:R:L251	R:R:T247	1.47	No	No	0	4	4
260	R:R:I250	R:R:I272	1.47	No	No	0	5	7
261	R:R:L269	R:R:T273	1.47	Yes	No	0	6	6
262	R:R:L277	R:R:T273	1.47	No	No	0	4	6
263	R:R:K89	R:R:K91	1.44	No	No	0	5	7
264	R:R:I180	R:R:L184	1.43	No	No	0	4	4
265	R:R:H304	R:R:S303	1.39	No	No	0	1	1
266	R:R:A317	R:R:F314	1.39	No	No	0	5	5
267	R:R:L275	R:R:L333	1.38	No	No	0	8	7
268	R:R:L329	R:R:L333	1.38	Yes	No	0	8	7
269	R:R:L259	R:R:N268	1.37	Yes	No	0	3	5
270	R:R:D168	R:R:L167	1.36	No	No	0	4	5
271	R:R:R263	R:R:S262	1.32	No	No	0	3	1
272	R:R:S310	R:R:Y119	1.27	No	Yes	0	2	4
273	R:R:F332	R:R:L79	1.22	No	No	0	6	6
274	R:R:F147	R:R:L185	1.22	No	No	0	6	4
275	R:R:R267	R:R:R271	1.07	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F70	4.7775	4	0	7
2	R:R:Y97	6.47333	6	1	7
3	R:R:L101	5.06	4	1	9
4	R:R:D105	7.53	5	1	9
5	R:R:Y119	6.294	5	0	4
6	R:R:W124	13.0475	4	3	8
7	R:R:F126	8.292	5	0	7
8	R:R:F143	5.89	4	0	6
9	R:R:M151	6.53	4	1	6
10	R:R:Y157	7.9675	4	4	7
11	R:R:N179	6.7325	4	1	7
12	R:R:F231	4.9175	4	2	5
13	R:R:F235	5.8675	4	2	8
14	R:R:L253	3.96	4	5	8
15	R:R:L259	3.4775	4	5	3
16	R:R:L269	3.235	4	0	6
17	R:R:W287	7.048	5	2	8
18	R:R:H291	5.7175	4	2	8
19	R:R:Y313	6.596	5	0	4
20	R:R:Y320	10.7225	4	2	6
21	R:R:N326	7.485	4	1	9
22	R:R:L329	3.0875	4	1	8
23	R:R:Y330	5.42143	7	1	9
24	R:R:F337	7.23833	6	1	8
25	L:L:?1	8.4925	12	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y119	R:R:Y313	16.0891	12.91	Yes	Yes	0	4	4
2	R:R:M112	R:R:V69	10.0459	1.52	No	No	0	7	7
3	R:R:M112	R:R:Y320	18.1348	17.96	No	Yes	0	7	6
4	R:R:Q115	R:R:Y313	28.2121	3.38	No	Yes	0	7	4
5	R:R:N322	R:R:N326	100	6.81	No	Yes	0	9	9
6	R:R:N322	R:R:W287	99.0085	14.69	No	Yes	0	9	8
7	L:L:?1	R:R:W287	95.0318	4.43	Yes	Yes	2	0	8
8	L:L:?1	R:R:Q115	28.3165	10.35	Yes	No	2	0	7
9	R:R:F337	R:R:V83	11.0479	14.42	Yes	No	1	8	8
10	R:R:F337	R:R:I98	28.7183	3.77	Yes	No	1	8	8
11	R:R:I98	R:R:Y330	26.1664	3.63	No	Yes	1	8	9
12	R:R:L101	R:R:Y330	52.6041	3.52	Yes	Yes	1	9	9
13	R:R:L101	R:R:N326	47.7351	6.87	Yes	Yes	1	9	9
14	R:R:L149	R:R:Y330	46.874	4.69	No	Yes	0	8	9
15	R:R:L149	R:R:N326	47.0358	5.49	No	Yes	0	8	9
16	R:R:M151	R:R:N179	16.2666	4.21	Yes	Yes	1	6	7
17	R:R:I182	R:R:M151	27.6693	4.37	No	Yes	0	7	6
18	R:R:F147	R:R:I182	27.7372	8.79	No	No	0	6	7
19	R:R:F147	R:R:I146	27.9877	3.77	No	No	0	6	7
20	R:R:F283	R:R:I146	31.0667	3.77	No	No	0	9	7
21	R:R:F283	R:R:W287	32.1835	5.01	No	Yes	0	9	8
22	R:R:N100	R:R:N179	21.1878	14.98	No	Yes	0	9	7
23	R:R:M151	R:R:Y97	11.0897	13.17	Yes	Yes	1	6	7
24	R:R:M152	R:R:Y97	28.3478	4.79	No	Yes	1	8	7
25	R:R:M152	R:R:Y330	25.4305	5.99	No	Yes	1	8	9
26	R:R:N100	R:R:W183	16.8719	5.65	No	No	0	9	9
27	R:R:W183	R:R:Y140	12.2586	11.58	No	No	0	9	5
28	R:R:F114	R:R:V134	32.9141	6.55	No	No	0	5	6
29	L:L:?1	R:R:V134	34.2292	4.63	Yes	No	0	0	6
30	R:R:F114	R:R:F126	31.5625	7.5	No	Yes	0	5	7
31	R:R:F126	R:R:W124	20.9425	18.04	Yes	Yes	0	7	8
32	R:R:C131	R:R:W124	16.1779	9.14	No	Yes	3	9	8
33	R:R:D128	R:R:T199	13.0362	8.67	No	No	0	2	4
34	R:R:C131	R:R:T199	14.6383	3.38	No	No	0	9	4
35	R:R:D128	R:R:K132	11.4237	13.83	No	No	0	2	6
36	R:R:F143	R:R:V189	10.2703	9.18	Yes	No	0	6	5
37	R:R:F143	R:R:M142	15.2594	4.98	Yes	No	0	6	7
38	R:R:S153	R:R:Y246	27.9564	6.36	No	No	0	9	8
39	R:R:R156	R:R:Y246	70.8277	9.26	No	No	0	9	8
40	R:R:R156	R:R:Y330	72.1063	10.29	No	Yes	0	9	9
41	R:R:C245	R:R:S153	17.4669	3.44	No	No	0	7	9
42	R:R:C245	R:R:Y157	15.7969	6.72	No	Yes	0	7	7
43	R:R:L259	R:R:L269	23.3483	4.15	Yes	Yes	0	3	6
44	R:R:L269	R:R:T273	29.5794	1.47	Yes	No	0	6	6
45	R:R:L277	R:R:T273	39.9593	1.47	No	No	0	4	6
46	R:R:L277	R:R:V276	41.6136	1.49	No	No	0	4	8
47	R:R:V276	R:R:Y246	43.0122	10.09	No	No	0	8	8
48	R:R:D223	R:R:F214	20.9373	9.55	No	No	0	4	6
49	R:R:D223	R:R:K227	22.4924	6.91	No	No	0	4	4
50	R:R:I294	R:R:K227	26.9231	8.72	No	No	0	5	4
51	L:L:?1	R:R:I294	31.2702	8.88	Yes	No	0	0	5
52	R:R:W221	R:R:W222	11.575	19.68	No	No	0	1	7
53	R:R:F214	R:R:W222	13.1823	2	No	No	0	6	7
54	R:R:F231	R:R:H291	11.6846	5.66	Yes	Yes	2	5	8
55	R:R:F235	R:R:H291	11.6115	7.92	Yes	Yes	2	8	8
56	R:R:L259	R:R:N268	16.778	1.37	Yes	No	0	3	5
57	R:R:N268	R:R:R271	13.1145	10.85	No	No	0	5	7
58	L:L:?1	R:R:Y320	18.281	10.03	Yes	Yes	2	0	6
59	R:R:N179	R:R:Y97	11.5176	3.49	Yes	Yes	1	7	7
60	R:R:M142	R:R:W287	11.7785	5.82	No	Yes	2	7	8
61	R:R:H291	R:R:W287	17.3729	5.29	Yes	Yes	2	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M112	R:R:Y320	17.96	0	No	Yes	7	6	2	1
R:R:F114	R:R:V134	6.55	0	No	No	5	6	2	1
R:R:Q115	R:R:Y313	3.38	2	No	Yes	7	4	1	2
R:R:Q115	R:R:Y320	11.27	2	No	Yes	7	6	1	1
L:L:?1	R:R:Q115	10.35	2	Yes	No	0	7	0	1
L:L:?1	R:R:V134	4.63	2	Yes	No	0	6	0	1
R:R:L135	R:R:L212	5.54	0	No	No	4	4	1	2
L:L:?1	R:R:L135	13.99	2	Yes	No	0	4	0	1
L:L:?1	R:R:D138	17.94	2	Yes	No	0	6	0	1
R:R:L212	R:R:Y139	3.52	0	No	No	4	5	2	1
R:R:M226	R:R:Y139	3.59	0	No	No	5	5	2	1
L:L:?1	R:R:Y139	6.38	2	Yes	No	0	5	0	1
R:R:F143	R:R:M142	4.98	0	Yes	No	6	7	2	1
R:R:M142	R:R:W287	5.82	2	No	Yes	7	8	1	1
L:L:?1	R:R:M142	5.5	2	Yes	No	0	7	0	1
R:R:I294	R:R:K227	8.72	0	No	No	5	4	1	2
R:R:F231	R:R:F235	6.43	2	Yes	Yes	5	8	2	2
R:R:F231	R:R:H291	5.66	2	Yes	Yes	5	8	2	1
R:R:F235	R:R:H291	7.92	2	Yes	Yes	8	8	2	1
R:R:F283	R:R:W287	5.01	0	No	Yes	9	8	2	1
R:R:H291	R:R:W287	5.29	2	Yes	Yes	8	8	1	1
R:R:N322	R:R:W287	14.69	0	No	Yes	9	8	2	1
L:L:?1	R:R:W287	4.43	2	Yes	Yes	0	8	0	1
R:R:I290	R:R:I294	4.42	0	No	No	6	5	2	1
L:L:?1	R:R:H291	4	2	Yes	Yes	0	8	0	1
R:R:F293	R:R:Y312	7.22	0	No	No	5	4	2	1
L:L:?1	R:R:I294	8.88	2	Yes	No	0	5	0	1
R:R:I316	R:R:Y312	10.88	2	No	No	5	4	1	1
L:L:?1	R:R:Y312	9.12	2	Yes	No	0	4	0	1
R:R:I316	R:R:Y320	3.63	2	No	Yes	5	6	1	1
L:L:?1	R:R:I316	6.66	2	Yes	No	0	5	0	1
L:L:?1	R:R:Y320	10.03	2	Yes	Yes	0	6	0	1
R:R:D138	R:R:T111	2.89	0	No	No	6	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8DZP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.38
Number of Linked Nodes	261
Number of Links	275
Number of Hubs	25
Number of Links mediated by Hubs	101
Number of Communities	5
Number of Nodes involved in Communities	34
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	38802
Length Of Smallest Path	3
Average Path Length	12.8727
Length of Longest Path	30
Minimum Path Strength	1.38
Average Path Strength	6.52255
Maximum Path Strength	20.12
Minimum Path Correlation	0.7
Average Path Correlation	0.918759
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	48.3522
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.498
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to virus • defense response to other organism • response to stress • response to external biotic stimulus • response to virus • response to acrylamide • response to chemical • response to oxygen-containing compound • response to nitrogen compound • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to hormone • response to endogenous stimulus • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • response to lipid • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • inorganic ion transmembrane transport • regulation of potassium ion transmembrane transport • inorganic cation transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • intracellular anatomical structure • cytoplasm • cytosol • presynapse • presynaptic membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • intracellular organelle • organelle • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • vesicle • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • organelle membrane • exocytic vesicle • mitochondrion • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • axon • axon terminus • distal axon • neuron projection terminus • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U99
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U99
Name	methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxododecahydro-2H-naphtho[2,1-c]pyran-7-carboxylate
Synonyms
Identifier
Formula	C23 H30 O8
Molecular Weight	434.48
SMILES
PubChem	44456192
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	7
Total Bonds	64
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>8DZP_nogp_Chain_R A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	10.1101/2025.01.09.632033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	10.1101/2025.01.09.632033
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	10.1038/s41467-023-43718-w
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	10.1093/procel/pwac033
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	10.1038/s41586-023-06030-7
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	10.1038/s41467-023-37041-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	10.1016/j.cell.2022.12.026
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	10.1038/s41467-020-14889-7
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	10.1016/j.cell.2017.12.011
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	10.1038/nature10939
	4DJH (Multimeric)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		2.9	2012-03-21	10.1038/nature10939

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Download 8DZP_nogp.zip

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