psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I58	R:R:P59	3.39	No	No	0	4	4
2	R:R:I58	R:R:S310	4.64	No	No	0	4	2
3	R:R:I62	R:R:Y66	2.42	No	Yes	0	5	6
4	R:R:I62	R:R:S310	3.1	No	No	0	5	2
5	R:R:L120	R:R:T63	2.95	No	No	0	4	5
6	R:R:M112	R:R:Y66	3.59	Yes	Yes	0	7	6
7	R:R:Y313	R:R:Y66	4.96	Yes	Yes	1	4	6
8	R:R:I316	R:R:Y66	2.42	Yes	Yes	1	5	6
9	R:R:A317	R:R:Y66	5.34	No	Yes	0	5	6
10	R:R:M112	R:R:V69	6.09	Yes	Yes	0	7	7
11	R:R:T321	R:R:V69	9.52	No	Yes	0	5	7
12	R:R:S324	R:R:V69	3.23	No	Yes	0	7	7
13	R:R:F70	R:R:L74	2.44	Yes	No	0	7	6
14	R:R:F70	R:R:T109	2.59	Yes	No	0	7	6
15	R:R:F70	R:R:M112	2.49	Yes	Yes	0	7	7
16	R:R:F70	R:R:P113	7.22	Yes	No	0	7	8
17	R:R:S324	R:R:V72	3.23	No	No	0	7	5
18	R:R:G73	R:R:S324	3.71	No	No	0	8	7
19	R:R:L74	R:R:S78	3	No	No	0	6	4
20	R:R:G76	R:R:P327	4.06	No	No	0	7	9
21	R:R:D105	R:R:N77	6.73	Yes	No	0	9	9
22	R:R:A106	R:R:N77	4.69	No	No	0	8	9
23	R:R:N77	R:R:P327	6.52	No	No	0	9	9
24	R:R:F332	R:R:L79	3.65	No	No	0	6	6
25	R:R:A102	R:R:V80	3.39	No	No	0	8	9
26	R:R:A331	R:R:V80	3.39	No	No	0	7	9
27	R:R:F332	R:R:V80	2.62	No	No	0	6	9
28	R:R:F99	R:R:M81	8.71	Yes	No	0	5	7
29	R:R:A102	R:R:M81	3.22	No	No	0	8	7
30	R:R:L103	R:R:M81	4.24	No	No	0	6	7
31	R:R:F82	R:R:Y87	6.19	No	No	0	4	5
32	R:R:V83	R:R:Y87	10.09	No	No	0	8	5
33	R:R:F337	R:R:V83	6.55	No	No	0	8	8
34	R:R:I84	R:R:M90	2.92	No	No	4	7	7
35	R:R:I84	R:R:N95	2.83	No	No	0	7	7
36	R:R:F99	R:R:I84	5.02	Yes	No	4	5	7
37	R:R:N95	R:R:T88	2.92	No	No	0	7	6
38	R:R:C340	R:R:T88	6.76	No	No	0	6	6
39	R:R:K89	R:R:K91	11.49	No	No	0	5	7
40	R:R:F99	R:R:M90	4.98	Yes	No	4	5	7
41	R:R:T92	R:R:T94	3.14	No	No	0	7	8
42	R:R:N95	R:R:T92	7.31	No	No	0	7	7
43	R:R:I98	R:R:T94	3.04	No	No	0	8	8
44	R:R:I96	R:R:K176	2.91	No	No	0	5	4
45	R:R:M152	R:R:Y97	5.99	No	Yes	0	8	7
46	R:R:D155	R:R:Y97	5.75	No	Yes	0	8	7
47	R:R:I178	R:R:Y97	3.63	Yes	Yes	0	6	7
48	R:R:N179	R:R:Y97	9.3	No	Yes	0	7	7
49	R:R:F99	R:R:N100	3.62	Yes	No	0	5	9
50	R:R:N100	R:R:N179	10.9	No	No	0	9	7
51	R:R:N100	R:R:W183	3.39	No	Yes	0	9	9
52	R:R:D105	R:R:L101	6.79	Yes	Yes	2	9	9
53	R:R:L101	R:R:T148	4.42	Yes	No	0	9	7
54	R:R:L101	R:R:L149	5.54	Yes	No	2	9	8
55	R:R:L101	R:R:Y330	4.69	Yes	Yes	2	9	9
56	R:R:L103	R:R:L107	4.15	No	No	0	6	6
57	R:R:L103	R:R:W183	4.56	No	Yes	0	6	9
58	R:R:D105	R:R:S145	5.89	Yes	No	0	9	9
59	R:R:D105	R:R:S323	4.42	Yes	No	2	9	8
60	R:R:D105	R:R:N326	8.08	Yes	Yes	2	9	9
61	R:R:L107	R:R:N141	12.36	No	Yes	0	6	8
62	R:R:V108	R:R:Y320	2.52	No	Yes	0	7	6
63	R:R:S323	R:R:V108	3.23	No	No	0	8	7
64	R:R:Q115	R:R:T111	5.67	Yes	Yes	1	7	7
65	R:R:T111	R:R:V134	4.76	Yes	Yes	1	7	6
66	R:R:D138	R:R:T111	15.9	Yes	Yes	1	6	7
67	R:R:T111	R:R:Y320	2.5	Yes	Yes	1	7	6
68	L:L:F211	R:R:T111	2.59	Yes	Yes	1	0	7
69	R:R:M112	R:R:Y320	3.59	Yes	Yes	0	7	6
70	R:R:F114	R:R:W124	7.02	No	Yes	1	5	8
71	R:R:F114	R:R:L130	7.31	No	Yes	1	5	5
72	R:R:F114	R:R:V134	5.24	No	Yes	1	5	6
73	R:R:D138	R:R:Q115	2.61	Yes	Yes	1	6	7
74	R:R:I316	R:R:Q115	2.74	Yes	Yes	1	5	7
75	R:R:Q115	R:R:Y320	12.4	Yes	Yes	1	7	6
76	L:L:F211	R:R:Q115	5.86	Yes	Yes	1	0	7
77	R:R:M121	R:R:T117	3.01	No	No	0	4	4
78	R:R:V118	R:R:W124	2.45	No	Yes	0	5	8
79	R:R:L120	R:R:Y119	4.69	No	No	0	4	4
80	R:R:Y119	R:R:Y313	13.9	No	Yes	0	4	4
81	R:R:S123	R:R:V207	3.23	No	No	0	4	3
82	R:R:F126	R:R:W124	14.03	Yes	Yes	1	7	8
83	R:R:L130	R:R:W124	5.69	Yes	Yes	1	5	8
84	R:R:C131	R:R:W124	3.92	Yes	Yes	1	9	8
85	R:R:C210	R:R:W124	2.61	Yes	Yes	1	9	8
86	R:R:F126	R:R:P125	5.78	Yes	No	0	7	1
87	R:R:F126	R:R:L130	4.87	Yes	Yes	1	7	5
88	R:R:C131	R:R:D128	3.11	Yes	Yes	1	9	2
89	R:R:D128	R:R:K132	4.15	Yes	No	0	2	6
90	R:R:D128	R:R:G198	5.03	Yes	No	0	2	4
91	R:R:D128	R:R:T199	11.56	Yes	No	1	2	4
92	R:R:I133	R:R:L130	2.85	No	Yes	0	5	5
93	R:R:L130	R:R:V134	2.98	Yes	Yes	1	5	6
94	R:R:C131	R:R:T199	3.38	Yes	No	1	9	4
95	R:R:C131	R:R:C210	7.28	Yes	Yes	1	9	9
96	L:L:F211	R:R:V134	3.93	Yes	Yes	1	0	6
97	R:R:I135	R:R:Y139	2.42	No	No	0	4	5
98	R:R:C210	R:R:I135	3.27	Yes	No	1	9	4
99	L:L:F211	R:R:I135	7.54	Yes	No	1	0	4
100	R:R:A193	R:R:S136	3.42	No	No	0	5	5
101	R:R:I194	R:R:S136	4.64	No	No	0	4	5
102	R:R:I137	R:R:N141	2.83	No	Yes	0	5	8
103	R:R:D138	R:R:Y320	8.05	Yes	Yes	1	6	6
104	L:L:F211	R:R:D138	2.39	Yes	Yes	1	0	6
105	R:R:L212	R:R:Y139	3.52	No	No	0	4	5
106	L:L:Y208	R:R:Y139	8.94	Yes	No	0	0	5
107	R:R:N141	R:R:Y140	6.98	Yes	Yes	3	8	5
108	R:R:T144	R:R:Y140	2.5	Yes	Yes	3	7	5
109	R:R:W183	R:R:Y140	8.68	Yes	Yes	3	9	5
110	R:R:S186	R:R:Y140	2.54	No	Yes	3	8	5
111	R:R:G190	R:R:Y140	2.9	No	Yes	0	6	5
112	R:R:N141	R:R:T144	2.92	Yes	Yes	3	8	7
113	R:R:F143	R:R:M142	3.73	Yes	No	0	6	7
114	R:R:M142	R:R:W287	3.49	No	Yes	0	7	8
115	L:L:Y208	R:R:M142	8.38	Yes	No	0	0	7
116	R:R:F143	R:R:V189	7.87	Yes	No	0	6	5
117	R:R:F143	R:R:V230	5.24	Yes	No	0	6	5
118	R:R:A234	R:R:F143	2.77	No	Yes	0	6	6
119	R:R:T144	R:R:W183	9.7	Yes	Yes	3	7	9
120	R:R:S186	R:R:T144	4.8	No	Yes	3	8	7
121	R:R:I146	R:R:P238	3.39	No	No	0	7	9
122	R:R:I146	R:R:W287	4.7	No	Yes	0	7	8
123	R:R:F147	R:R:L185	2.44	No	No	0	6	4
124	R:R:F283	R:R:L149	2.44	Yes	No	2	9	8
125	R:R:L149	R:R:Y330	7.03	No	Yes	2	8	9
126	R:R:P238	R:R:T150	3.5	No	No	0	9	7
127	R:R:I241	R:R:T150	4.56	No	No	0	6	7
128	R:R:M151	R:R:V154	3.04	No	No	0	6	6
129	R:R:I178	R:R:M151	2.92	Yes	No	5	6	6
130	R:R:I182	R:R:M151	4.37	No	No	5	7	6
131	R:R:M152	R:R:Y330	2.39	No	Yes	0	8	9
132	R:R:I242	R:R:S153	4.64	No	No	7	8	9
133	R:R:C245	R:R:S153	3.44	No	No	0	7	9
134	R:R:S153	R:R:Y246	11.45	No	Yes	7	9	8
135	R:R:I158	R:R:V154	3.07	No	No	0	5	6
136	R:R:D155	R:R:F169	4.78	No	Yes	0	8	4
137	R:R:D155	R:R:R170	11.91	No	No	0	8	6
138	R:R:R156	R:R:Y246	10.29	No	Yes	0	9	8
139	R:R:C161	R:R:Y157	6.72	No	No	0	7	7
140	R:R:C245	R:R:Y157	9.41	No	No	0	7	7
141	R:R:L248	R:R:Y157	7.03	No	No	0	4	7
142	R:R:F169	R:R:I158	15.07	Yes	No	0	4	5
143	R:R:A159	R:R:R170	4.15	No	No	0	8	6
144	R:R:M249	R:R:V160	6.09	No	No	0	8	8
145	R:R:L253	R:R:V160	2.98	No	No	0	8	8
146	R:R:C161	R:R:H162	2.95	No	No	0	7	6
147	R:R:C161	R:R:R252	2.79	No	No	0	7	5
148	R:R:F169	R:R:K174	3.72	Yes	No	0	4	5
149	R:R:F169	R:R:I178	2.51	Yes	Yes	0	4	6
150	R:R:P172	R:R:T171	5.25	No	No	0	2	7
151	R:R:I178	R:R:I182	2.94	Yes	No	5	6	7
152	R:R:I180	R:R:L184	2.85	No	No	0	4	4
153	R:R:I191	R:R:S187	3.1	No	No	0	4	4
154	R:R:S188	R:R:V189	3.23	No	No	0	4	5
155	R:R:F214	R:R:L196	6.09	Yes	No	0	6	4
156	R:R:G198	R:R:Q213	4.93	No	No	0	4	4
157	R:R:E209	R:R:K200	8.1	No	Yes	9	3	2
158	R:R:K200	R:R:Q213	8.14	Yes	No	0	2	4
159	R:R:D216	R:R:K200	2.77	No	Yes	0	2	2
160	L:L:R213	R:R:K200	4.95	No	Yes	9	0	2
161	R:R:I208	R:R:V201	6.14	No	No	0	4	2
162	R:R:D204	R:R:R202	15.48	No	No	10	2	2
163	R:R:R202	R:R:V205	2.62	No	No	10	2	1
164	R:R:D204	R:R:V205	4.38	No	No	10	2	1
165	R:R:V205	R:R:V207	3.21	No	No	0	1	3
166	R:R:E209	R:R:S211	4.31	No	No	0	3	4
167	L:L:R213	R:R:E209	4.65	No	No	9	0	3
168	L:L:F211	R:R:C210	2.79	Yes	Yes	1	0	9
169	R:R:F214	R:R:L212	2.44	Yes	No	6	6	4
170	R:R:L212	R:R:M226	2.83	No	No	6	4	5
171	R:R:F214	R:R:Y219	6.19	Yes	No	0	6	1
172	R:R:D223	R:R:F214	3.58	No	Yes	0	4	6
173	R:R:F214	R:R:M226	3.73	Yes	No	6	6	5
174	R:R:D216	R:R:Y219	3.45	No	No	0	2	1
175	R:R:D217	R:R:D218	6.65	No	No	0	1	4
176	L:L:R213	R:R:Y219	24.69	No	No	0	0	1
177	R:R:W221	R:R:W222	10.31	No	Yes	0	1	7
178	R:R:D223	R:R:K227	12.44	No	Yes	0	4	4
179	R:R:I228	R:R:L224	2.85	No	No	0	5	3
180	R:R:L224	R:R:L299	2.77	No	No	0	3	4
181	R:R:C229	R:R:F225	8.38	No	No	0	3	4
182	R:R:M226	R:R:V230	3.04	No	No	0	5	5
183	R:R:I294	R:R:K227	2.91	No	Yes	0	5	4
184	R:R:A298	R:R:K227	3.21	No	Yes	0	4	4
185	L:L:L212	R:R:K227	4.23	No	Yes	0	0	4
186	L:L:Y208	R:R:V230	5.05	Yes	No	0	0	5
187	R:R:F231	R:R:I232	3.77	Yes	No	2	5	5
188	R:R:F231	R:R:F235	9.65	Yes	Yes	2	5	8
189	R:R:F231	R:R:V236	2.62	Yes	No	2	5	4
190	R:R:F231	R:R:H291	10.18	Yes	No	2	5	8
191	R:R:F231	R:R:L295	12.18	Yes	No	0	5	5
192	R:R:I232	R:R:V236	4.61	No	No	2	5	4
193	R:R:F235	R:R:V239	3.93	Yes	No	0	8	6
194	R:R:F235	R:R:T288	6.49	Yes	Yes	0	8	5
195	R:R:F235	R:R:H291	3.39	Yes	No	2	8	8
196	R:R:I237	R:R:P238	3.39	No	No	0	5	9
197	R:R:I237	R:R:I241	2.94	No	No	0	5	6
198	R:R:F283	R:R:V239	2.62	Yes	No	0	9	6
199	R:R:I242	R:R:Y246	3.63	No	Yes	7	8	8
200	R:R:L248	R:R:V244	2.98	No	No	0	4	4
201	R:R:M249	R:R:Y246	4.79	No	Yes	0	8	8
202	R:R:V276	R:R:Y246	7.57	No	Yes	0	8	8
203	R:R:V280	R:R:Y246	2.52	No	Yes	0	8	8
204	R:R:I250	R:R:T273	3.04	No	No	0	5	6
205	R:R:L253	R:R:L259	4.15	No	Yes	8	8	3
206	R:R:L253	R:R:L269	2.77	No	Yes	8	8	6
207	R:R:K254	R:R:L269	4.23	No	Yes	0	4	6
208	R:R:L259	R:R:V256	8.94	Yes	No	0	3	6
209	R:R:K265	R:R:L259	2.82	No	Yes	0	4	3
210	R:R:L259	R:R:L269	8.3	Yes	Yes	8	3	6
211	R:R:N268	R:R:R271	3.62	No	No	0	5	7
212	R:R:L269	R:R:T273	2.95	Yes	No	0	6	6
213	R:R:R270	R:R:R274	5.33	No	No	0	5	6
214	R:R:E335	R:R:R271	9.3	No	No	0	4	7
215	R:R:L277	R:R:T273	2.95	No	No	0	4	6
216	R:R:L275	R:R:L333	2.77	No	No	0	8	7
217	R:R:V279	R:R:Y330	3.79	No	Yes	0	8	9
218	R:R:N322	R:R:V282	2.96	Yes	No	0	9	7
219	R:R:L329	R:R:V282	4.47	No	No	0	8	7
220	R:R:F283	R:R:W287	11.02	Yes	Yes	2	9	8
221	R:R:F283	R:R:N322	3.62	Yes	Yes	2	9	9
222	R:R:T288	R:R:V284	4.76	Yes	No	0	5	6
223	R:R:C286	R:R:N322	7.87	No	Yes	0	8	9
224	R:R:H291	R:R:W287	5.29	No	Yes	2	8	8
225	R:R:N322	R:R:W287	4.52	Yes	Yes	2	9	8
226	R:R:P289	R:R:T288	3.5	No	Yes	0	9	5
227	R:R:I292	R:R:T288	3.04	No	Yes	0	5	5
228	R:R:I290	R:R:I294	5.89	Yes	No	0	6	5
229	R:R:I290	R:R:Y312	2.42	Yes	Yes	1	6	4
230	R:R:C315	R:R:I290	4.91	No	Yes	0	7	6
231	R:R:I290	R:R:I316	2.94	Yes	Yes	1	6	5
232	R:R:E297	R:R:F293	9.33	No	No	0	5	5
233	R:R:F293	R:R:S311	2.64	No	No	0	5	4
234	R:R:F293	R:R:Y312	8.25	No	Yes	0	5	4
235	L:L:Y208	R:R:I294	2.42	Yes	No	0	0	5
236	L:L:R214	R:R:E297	10.47	No	No	0	0	5
237	R:R:G300	R:R:L299	3.42	No	No	0	2	4
238	R:R:L309	R:R:Y313	4.69	No	Yes	0	4	4
239	L:L:R214	R:R:L309	6.07	No	No	0	0	4
240	R:R:Y312	R:R:Y313	8.94	Yes	Yes	1	4	4
241	R:R:I316	R:R:Y312	6.04	Yes	Yes	1	5	4
242	L:L:G209	R:R:Y312	2.9	No	Yes	1	0	4
243	L:L:R214	R:R:Y312	19.55	No	Yes	0	0	4
244	R:R:I316	R:R:Y313	2.42	Yes	Yes	1	5	4
245	L:L:G210	R:R:Y313	2.9	No	Yes	0	0	4
246	R:R:F314	R:R:L318	9.74	No	No	0	5	8
247	R:R:I316	R:R:Y320	2.42	Yes	Yes	1	5	6
248	L:L:G209	R:R:I316	3.53	No	Yes	1	0	5
249	R:R:L325	R:R:T321	2.95	No	No	0	6	5
250	R:R:N322	R:R:N326	6.81	Yes	Yes	2	9	9
251	R:R:N326	R:R:S323	2.98	Yes	No	2	9	8
252	R:R:N326	R:R:Y330	5.81	Yes	Yes	2	9	9
253	R:R:A331	R:R:F337	5.55	No	No	0	7	8
254	R:R:E335	R:R:K338	9.45	No	No	0	4	8
255	R:R:R339	R:R:R342	3.2	No	No	0	5	5
256	L:L:G209	L:L:Y208	4.35	No	Yes	0	0	0
257	R:R:E264	R:R:R267	2.33	No	No	0	3	4
258	R:R:D218	R:R:W222	2.23	No	Yes	0	4	7
259	R:R:F143	R:R:F147	2.14	Yes	No	0	6	6
260	R:R:G197	R:R:G198	2.11	No	No	0	4	4
261	R:R:F225	R:R:W222	2	No	Yes	0	4	7
262	R:R:G190	R:R:S136	1.86	No	No	0	6	5
263	R:R:A175	R:R:A93	1.79	No	No	0	7	6
264	R:R:A104	R:R:S145	1.71	No	No	0	8	9
265	R:R:C245	R:R:V154	1.71	No	No	0	7	6
266	R:R:A308	R:R:S305	1.71	No	No	0	3	3
267	R:R:A308	R:R:S311	1.71	No	No	0	3	4
268	R:R:I96	R:R:P172	1.69	No	No	0	5	2
269	R:R:A307	R:R:T306	1.68	No	No	0	4	2
270	R:R:C181	R:R:I177	1.64	No	No	0	4	3
271	R:R:S303	R:R:S305	1.63	No	No	0	1	3
272	R:R:S301	R:R:V296	1.62	No	No	0	2	4
273	R:R:S67	R:R:T63	1.6	No	No	0	4	5
274	R:R:S116	R:R:T63	1.6	No	No	0	6	5
275	R:R:V65	R:R:V69	1.6	No	Yes	0	5	7
276	R:R:V68	R:R:V72	1.6	No	No	0	5	5
277	R:R:V71	R:R:V75	1.6	No	No	0	5	4
278	R:R:V278	R:R:V282	1.6	No	No	0	5	7
279	R:R:A298	R:R:L224	1.58	No	No	0	4	3
280	R:R:C340	R:R:N336	1.57	No	No	0	6	6
281	R:R:I208	R:R:S123	1.55	No	No	0	4	4
282	R:R:I191	R:R:V195	1.54	No	No	0	4	4
283	R:R:I243	R:R:V239	1.54	No	No	0	5	6
284	R:R:I243	R:R:V280	1.54	No	No	0	5	8
285	R:R:I292	R:R:V296	1.54	No	No	0	5	4
286	R:R:H162	R:R:P163	1.53	No	No	0	6	8
287	R:R:I208	R:R:T199	1.52	No	No	0	4	4
288	R:R:I243	R:R:T247	1.52	No	No	0	5	4
289	R:R:F126	R:R:G127	1.51	Yes	No	0	7	7
290	R:R:K174	R:R:T171	1.5	No	No	0	5	7
291	R:R:L240	R:R:V236	1.49	No	No	0	3	4
292	R:R:L258	R:R:V256	1.49	No	No	0	5	6
293	R:R:L173	R:R:T171	1.47	No	No	0	4	7
294	R:R:L251	R:R:T247	1.47	No	No	0	4	4
295	R:R:F214	R:R:P215	1.44	Yes	No	0	6	5
296	R:R:I177	R:R:L173	1.43	No	No	0	3	4
297	R:R:D334	R:R:I98	1.4	No	No	0	8	8
298	R:R:C229	R:R:F233	1.4	No	No	0	3	4
299	R:R:K265	R:R:N268	1.4	No	No	0	4	5
300	R:R:A93	R:R:R170	1.38	No	No	0	6	6
301	R:R:D168	R:R:L167	1.36	No	No	0	4	5
302	R:R:R252	R:R:S255	1.32	No	No	0	5	4
303	R:R:F70	R:R:V71	1.31	Yes	No	0	7	5
304	R:R:H162	R:R:K165	1.31	No	No	0	6	4
305	R:R:F126	R:R:T117	1.3	Yes	No	0	7	4
306	R:R:S187	R:R:Y140	1.27	No	Yes	0	4	5
307	R:R:F99	R:R:I85	1.26	Yes	No	0	5	3
308	R:R:F332	R:R:I328	1.26	No	No	0	6	7
309	R:R:K338	R:R:R342	1.24	No	No	0	8	5
310	R:R:L277	R:R:R274	1.21	No	No	0	4	6
311	R:R:F214	R:R:W222	1	Yes	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y66	3.746	5	1	6
2	R:R:V69	5.11	4	0	7
3	R:R:F70	3.21	5	0	7
4	R:R:Y97	6.1675	4	0	7
5	R:R:F99	4.718	5	4	5
6	R:R:L101	5.36	4	2	9
7	R:R:D105	6.382	5	2	9
8	R:R:T111	6.284	5	1	7
9	R:R:M112	3.94	4	0	7
10	R:R:Q115	5.856	5	1	7
11	R:R:W124	5.95333	6	1	8
12	R:R:F126	5.498	5	1	7
13	R:R:D128	5.9625	4	1	2
14	R:R:L130	4.74	5	1	5
15	R:R:C131	4.4225	4	1	9
16	R:R:V134	4.2275	4	1	6
17	R:R:D138	7.2375	4	1	6
18	R:R:Y140	4.145	6	3	5
19	R:R:N141	6.2725	4	3	8
20	R:R:F143	4.35	5	0	6
21	R:R:T144	4.98	4	3	7
22	R:R:F169	6.52	4	0	4
23	R:R:I178	3	4	5	6
24	R:R:W183	6.5825	4	3	9
25	R:R:K200	5.99	4	9	2
26	R:R:C210	3.9875	4	1	9
27	R:R:F214	3.49571	7	6	6
28	R:R:W222	3.885	4	0	7
29	R:R:K227	5.6975	4	0	4
30	R:R:F231	7.68	5	2	5
31	R:R:F235	5.865	4	2	8
32	R:R:Y246	6.70833	6	7	8
33	R:R:L259	6.0525	4	8	3
34	R:R:L269	4.5625	4	8	6
35	R:R:F283	4.925	4	2	9
36	R:R:W287	5.804	5	2	8
37	R:R:T288	4.4475	4	0	5
38	R:R:I290	4.04	4	1	6
39	R:R:Y312	8.01667	6	1	4
40	R:R:Y313	6.30167	6	1	4
41	R:R:I316	3.21571	7	1	5
42	R:R:Y320	5.24667	6	1	6
43	R:R:N322	5.156	5	2	9
44	R:R:N326	5.92	4	2	9
45	R:R:Y330	4.742	5	2	9
46	L:L:Y208	5.828	5	0	0
47	L:L:F211	4.18333	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M112	R:R:Y66	10.6805	3.59	Yes	Yes	0	7	6
2	R:R:I316	R:R:Y66	13.8451	2.42	Yes	Yes	1	5	6
3	R:R:M112	R:R:V69	16.5873	6.09	Yes	Yes	0	7	7
4	R:R:F70	R:R:M112	14.5403	2.49	Yes	Yes	0	7	7
5	R:R:S323	R:R:V108	50.5262	3.23	No	No	0	8	7
6	R:R:V108	R:R:Y320	50.8564	2.52	No	Yes	0	7	6
7	R:R:M112	R:R:Y320	27.3946	3.59	Yes	Yes	0	7	6
8	R:R:I316	R:R:Y320	19.2526	2.42	Yes	Yes	1	5	6
9	R:R:A102	R:R:V80	15.3775	3.39	No	No	0	8	9
10	R:R:A102	R:R:M81	17.0482	3.22	No	No	0	8	7
11	R:R:F99	R:R:M81	18.2195	8.71	Yes	No	0	5	7
12	R:R:F99	R:R:N100	37.3608	3.62	Yes	No	0	5	9
13	R:R:N100	R:R:N179	66.7448	10.9	No	No	0	9	7
14	R:R:N179	R:R:Y97	68.1696	9.3	No	Yes	0	7	7
15	R:R:M152	R:R:Y97	99.109	5.99	No	Yes	0	8	7
16	R:R:M152	R:R:Y330	100	2.39	No	Yes	0	8	9
17	R:R:N326	R:R:Y330	68.4423	5.81	Yes	Yes	2	9	9
18	R:R:N326	R:R:S323	45.5834	2.98	Yes	No	2	9	8
19	R:R:N100	R:R:W183	29.4224	3.39	No	Yes	0	9	9
20	R:R:F99	R:R:I84	15.4505	5.02	Yes	No	4	5	7
21	R:R:I84	R:R:N95	13.7914	2.83	No	No	0	7	7
22	R:R:D155	R:R:Y97	22.1369	5.75	No	Yes	0	8	7
23	R:R:D155	R:R:F169	15.558	4.78	No	Yes	0	8	4
24	R:R:F169	R:R:K174	25.1095	3.72	Yes	No	0	4	5
25	R:R:K174	R:R:T171	22.1753	1.5	No	No	0	5	7
26	R:R:I178	R:R:Y97	29.3801	3.63	Yes	Yes	0	6	7
27	R:R:F169	R:R:I178	14.7554	2.51	Yes	Yes	0	4	6
28	R:R:L149	R:R:Y330	31.1967	7.03	No	Yes	2	8	9
29	L:L:G209	R:R:I316	17.2479	3.53	No	Yes	1	0	5
30	L:L:G209	L:L:Y208	25.8123	4.35	No	Yes	0	0	0
31	L:L:Y208	R:R:M142	67.39	8.38	Yes	No	0	0	7
32	R:R:M142	R:R:W287	87.4261	3.49	No	Yes	0	7	8
33	R:R:F283	R:R:W287	50.8756	11.02	Yes	Yes	2	9	8
34	R:R:F283	R:R:L149	33.5433	2.44	Yes	No	2	9	8
35	R:R:W183	R:R:Y140	18.4922	8.68	Yes	Yes	3	9	5
36	R:R:T111	R:R:Y320	17.6089	2.5	Yes	Yes	1	7	6
37	L:L:F211	R:R:Q115	12.9311	5.86	Yes	Yes	1	0	7
38	R:R:D138	R:R:Y320	10.1774	8.05	Yes	Yes	1	6	6
39	L:L:F211	R:R:C210	24.0725	2.79	Yes	Yes	1	0	9
40	R:R:C131	R:R:C210	25.0096	7.28	Yes	Yes	1	9	9
41	R:R:C131	R:R:T199	14.3406	3.38	Yes	No	1	9	4
42	R:R:I208	R:R:T199	12.8965	1.52	No	No	0	4	4
43	L:L:Y208	R:R:Y139	33.2092	8.94	Yes	No	0	0	5
44	R:R:L212	R:R:Y139	26.2731	3.52	No	No	0	4	5
45	R:R:F143	R:R:M142	25.2516	3.73	Yes	No	0	6	7
46	R:R:F143	R:R:V230	20.4816	5.24	Yes	No	0	6	5
47	L:L:Y208	R:R:V230	24.7945	5.05	Yes	No	0	0	5
48	R:R:I178	R:R:M151	12.1131	2.92	Yes	No	5	6	6
49	R:R:M151	R:R:V154	10.9225	3.04	No	No	0	6	6
50	R:R:V280	R:R:Y246	28.5429	2.52	No	Yes	0	8	8
51	R:R:I243	R:R:V280	29.2342	1.54	No	No	0	5	8
52	R:R:I243	R:R:V239	31.7958	1.54	No	No	0	5	6
53	R:R:F283	R:R:V239	35.2677	2.62	Yes	No	0	9	6
54	R:R:S153	R:R:Y246	14.8206	11.45	No	Yes	7	9	8
55	R:R:C245	R:R:S153	14.4443	3.44	No	No	0	7	9
56	R:R:C245	R:R:V154	12.2552	1.71	No	No	0	7	6
57	R:R:C245	R:R:Y157	11.5063	9.41	No	No	0	7	7
58	R:R:M249	R:R:Y246	22.9242	4.79	No	Yes	0	8	8
59	R:R:M249	R:R:V160	21.822	6.09	No	No	0	8	8
60	R:R:L253	R:R:V160	20.8234	2.98	No	No	0	8	8
61	R:R:F214	R:R:L212	24.8598	2.44	Yes	No	6	6	4
62	R:R:F214	R:R:M226	35.7631	3.73	Yes	No	6	6	5
63	R:R:M226	R:R:V230	37.7794	3.04	No	No	0	5	5
64	R:R:I294	R:R:K227	15.4082	2.91	No	Yes	0	5	4
65	L:L:R213	R:R:Y219	15.5849	24.69	No	No	0	0	1
66	R:R:F214	R:R:Y219	27.4983	6.19	Yes	No	0	6	1
67	R:R:F214	R:R:W222	27.7671	1	Yes	Yes	0	6	7
68	R:R:F225	R:R:W222	11.9441	2	No	Yes	0	4	7
69	R:R:H291	R:R:W287	14.8514	5.29	No	Yes	2	8	8
70	R:R:L253	R:R:L259	11.7021	4.15	No	Yes	8	8	3
71	R:R:N322	R:R:N326	38.0252	6.81	Yes	Yes	2	9	9
72	R:R:N322	R:R:W287	33.5625	4.52	Yes	Yes	2	9	8
73	R:R:I135	R:R:Y139	16.4567	2.42	No	No	0	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y313	R:R:Y66	4.96	1	Yes	Yes	4	6	1	2
R:R:I316	R:R:Y66	2.42	1	Yes	Yes	5	6	1	2
R:R:Q115	R:R:T111	5.67	1	Yes	Yes	7	7	1	1
R:R:T111	R:R:V134	4.76	1	Yes	Yes	7	6	1	1
R:R:D138	R:R:T111	15.9	1	Yes	Yes	6	7	1	1
R:R:T111	R:R:Y320	2.5	1	Yes	Yes	7	6	1	2
L:L:F211	R:R:T111	2.59	1	Yes	Yes	0	7	0	1
R:R:F114	R:R:W124	7.02	1	No	Yes	5	8	2	2
R:R:F114	R:R:L130	7.31	1	No	Yes	5	5	2	2
R:R:F114	R:R:V134	5.24	1	No	Yes	5	6	2	1
R:R:D138	R:R:Q115	2.61	1	Yes	Yes	6	7	1	1
R:R:I316	R:R:Q115	2.74	1	Yes	Yes	5	7	1	1
R:R:Q115	R:R:Y320	12.4	1	Yes	Yes	7	6	1	2
L:L:F211	R:R:Q115	5.86	1	Yes	Yes	0	7	0	1
R:R:Y119	R:R:Y313	13.9	0	No	Yes	4	4	2	1
R:R:L130	R:R:W124	5.69	1	Yes	Yes	5	8	2	2
R:R:C131	R:R:W124	3.92	1	Yes	Yes	9	8	2	2
R:R:C210	R:R:W124	2.61	1	Yes	Yes	9	8	1	2
R:R:L130	R:R:V134	2.98	1	Yes	Yes	5	6	2	1
R:R:C131	R:R:C210	7.28	1	Yes	Yes	9	9	2	1
L:L:F211	R:R:V134	3.93	1	Yes	Yes	0	6	0	1
R:R:I135	R:R:Y139	2.42	1	No	No	4	5	1	1
R:R:C210	R:R:I135	3.27	1	Yes	No	9	4	1	1
L:L:F211	R:R:I135	7.54	1	Yes	No	0	4	0	1
R:R:D138	R:R:Y320	8.05	1	Yes	Yes	6	6	1	2
L:L:F211	R:R:D138	2.39	1	Yes	Yes	0	6	0	1
R:R:L212	R:R:Y139	3.52	6	No	No	4	5	2	1
L:L:Y208	R:R:Y139	8.94	0	Yes	No	0	5	0	1
R:R:F143	R:R:M142	3.73	0	Yes	No	6	7	2	1
R:R:M142	R:R:W287	3.49	0	No	Yes	7	8	1	2
L:L:Y208	R:R:M142	8.38	0	Yes	No	0	7	0	1
R:R:F143	R:R:V230	5.24	0	Yes	No	6	5	2	1
R:R:E209	R:R:K200	8.1	9	No	Yes	3	2	1	1
R:R:K200	R:R:Q213	8.14	9	Yes	No	2	4	1	2
R:R:D216	R:R:K200	2.77	0	No	Yes	2	2	2	1
L:L:R213	R:R:K200	4.95	9	No	Yes	0	2	0	1
R:R:E209	R:R:S211	4.31	9	No	No	3	4	1	2
L:L:R213	R:R:E209	4.65	9	No	No	0	3	0	1
L:L:F211	R:R:C210	2.79	1	Yes	Yes	0	9	0	1
R:R:F214	R:R:L212	2.44	6	Yes	No	6	4	2	2
R:R:L212	R:R:M226	2.83	6	No	No	4	5	2	2
R:R:F214	R:R:Y219	6.19	6	Yes	No	6	1	2	1
R:R:D223	R:R:F214	3.58	0	No	Yes	4	6	2	2
R:R:F214	R:R:M226	3.73	6	Yes	No	6	5	2	2
R:R:D216	R:R:Y219	3.45	0	No	No	2	1	2	1
L:L:R213	R:R:Y219	24.69	9	No	No	0	1	0	1
R:R:D223	R:R:K227	12.44	0	No	Yes	4	4	2	1
R:R:M226	R:R:V230	3.04	6	No	No	5	5	2	1
R:R:I294	R:R:K227	2.91	0	No	Yes	5	4	1	1
R:R:A298	R:R:K227	3.21	0	No	Yes	4	4	2	1
L:L:L212	R:R:K227	4.23	0	No	Yes	0	4	0	1
L:L:Y208	R:R:V230	5.05	0	Yes	No	0	5	0	1
R:R:I290	R:R:I294	5.89	1	Yes	No	6	5	2	1
R:R:I290	R:R:Y312	2.42	1	Yes	Yes	6	4	2	1
R:R:I290	R:R:I316	2.94	1	Yes	Yes	6	5	2	1
R:R:E297	R:R:F293	9.33	0	No	No	5	5	1	2
R:R:F293	R:R:Y312	8.25	0	No	Yes	5	4	2	1
L:L:Y208	R:R:I294	2.42	0	Yes	No	0	5	0	1
L:L:R214	R:R:E297	10.47	0	No	No	0	5	0	1
R:R:L309	R:R:Y313	4.69	0	No	Yes	4	4	1	1
L:L:R214	R:R:L309	6.07	0	No	No	0	4	0	1
R:R:Y312	R:R:Y313	8.94	1	Yes	Yes	4	4	1	1
R:R:I316	R:R:Y312	6.04	1	Yes	Yes	5	4	1	1
L:L:G209	R:R:Y312	2.9	1	No	Yes	0	4	0	1
L:L:R214	R:R:Y312	19.55	0	No	Yes	0	4	0	1
R:R:I316	R:R:Y313	2.42	1	Yes	Yes	5	4	1	1
L:L:G210	R:R:Y313	2.9	0	No	Yes	0	4	0	1
R:R:I316	R:R:Y320	2.42	1	Yes	Yes	5	6	1	2
L:L:G209	R:R:I316	3.53	1	No	Yes	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F7W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.39
Number of Linked Nodes	266
Number of Links	311
Number of Hubs	47
Number of Links mediated by Hubs	170
Number of Communities	10
Number of Nodes involved in Communities	61
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	62754
Length Of Smallest Path	3
Average Path Length	13.2315
Length of Longest Path	29
Minimum Path Strength	1.22
Average Path Strength	4.81345
Maximum Path Strength	15.44
Minimum Path Correlation	0.7
Average Path Correlation	0.91831
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	45.8928
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.8084
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • defense response to virus • defense response • response to other organism • response to stress • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • response to acrylamide • response to chemical • response to oxygen-containing compound • response to nitrogen compound • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to hormone • response to endogenous stimulus • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • response to lipid • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • regulation of potassium ion transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • intracellular anatomical structure • cytoplasm • cytosol • presynapse • presynaptic membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • intracellular organelle • organelle • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • vesicle • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • organelle membrane • exocytic vesicle • mitochondrion • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • axon • axon terminus • distal axon • neuron projection terminus • opioid peptide activity • protein binding • binding • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • multicellular organismal process • system process • sensory perception • nervous system process • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • dense core granule • secretory granule • neuronal dense core vesicle • extracellular region • D2 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • cell projection membrane • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>8F7W_nogp_Chain_R A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	doi.org/10.1016/j.cell.2017.12.011
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	doi.org/10.1038/nature10939
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	doi.org/10.1038/s41467-020-14889-7
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	doi.org/10.1038/s41467-023-37041-7
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0

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