Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y66 3.746516
2R:R:V69 5.11407
3R:R:F70 3.21507
4R:R:Y97 6.1675407
5R:R:F99 4.718545
6R:R:L101 5.36429
7R:R:D105 6.382529
8R:R:T111 6.284517
9R:R:M112 3.94407
10R:R:Q115 5.856517
11R:R:W124 5.95333618
12R:R:F126 5.498517
13R:R:D128 5.9625412
14R:R:L130 4.74515
15R:R:C131 4.4225419
16R:R:V134 4.2275416
17R:R:D138 7.2375416
18R:R:Y140 4.145635
19R:R:N141 6.2725438
20R:R:F143 4.35506
21R:R:T144 4.98437
22R:R:F169 6.52404
23R:R:I178 3456
24R:R:W183 6.5825439
25R:R:K200 5.99492
26R:R:C210 3.9875419
27R:R:F214 3.49571766
28R:R:W222 3.885407
29R:R:K227 5.6975404
30R:R:F231 7.68525
31R:R:F235 5.865428
32R:R:Y246 6.70833678
33R:R:L259 6.0525483
34R:R:L269 4.5625486
35R:R:F283 4.925429
36R:R:W287 5.804528
37R:R:T288 4.4475405
38R:R:I290 4.04416
39R:R:Y312 8.01667614
40R:R:Y313 6.30167614
41R:R:I316 3.21571715
42R:R:Y320 5.24667616
43R:R:N322 5.156529
44R:R:N326 5.92429
45R:R:Y330 4.742529
46L:L:Y208 5.828500
47L:L:F211 4.18333610
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M112 R:R:Y66 10.68053.59YesYes076
2R:R:I316 R:R:Y66 13.84512.42YesYes156
3R:R:M112 R:R:V69 16.58736.09YesYes077
4R:R:F70 R:R:M112 14.54032.49YesYes077
5R:R:S323 R:R:V108 50.52623.23NoNo087
6R:R:V108 R:R:Y320 50.85642.52NoYes076
7R:R:M112 R:R:Y320 27.39463.59YesYes076
8R:R:I316 R:R:Y320 19.25262.42YesYes156
9R:R:A102 R:R:V80 15.37753.39NoNo089
10R:R:A102 R:R:M81 17.04823.22NoNo087
11R:R:F99 R:R:M81 18.21958.71YesNo057
12R:R:F99 R:R:N100 37.36083.62YesNo059
13R:R:N100 R:R:N179 66.744810.9NoNo097
14R:R:N179 R:R:Y97 68.16969.3NoYes077
15R:R:M152 R:R:Y97 99.1095.99NoYes087
16R:R:M152 R:R:Y330 1002.39NoYes089
17R:R:N326 R:R:Y330 68.44235.81YesYes299
18R:R:N326 R:R:S323 45.58342.98YesNo298
19R:R:N100 R:R:W183 29.42243.39NoYes099
20R:R:F99 R:R:I84 15.45055.02YesNo457
21R:R:I84 R:R:N95 13.79142.83NoNo077
22R:R:D155 R:R:Y97 22.13695.75NoYes087
23R:R:D155 R:R:F169 15.5584.78NoYes084
24R:R:F169 R:R:K174 25.10953.72YesNo045
25R:R:K174 R:R:T171 22.17531.5NoNo057
26R:R:I178 R:R:Y97 29.38013.63YesYes067
27R:R:F169 R:R:I178 14.75542.51YesYes046
28R:R:L149 R:R:Y330 31.19677.03NoYes289
29L:L:G209 R:R:I316 17.24793.53NoYes105
30L:L:G209 L:L:Y208 25.81234.35NoYes000
31L:L:Y208 R:R:M142 67.398.38YesNo007
32R:R:M142 R:R:W287 87.42613.49NoYes078
33R:R:F283 R:R:W287 50.875611.02YesYes298
34R:R:F283 R:R:L149 33.54332.44YesNo298
35R:R:W183 R:R:Y140 18.49228.68YesYes395
36R:R:T111 R:R:Y320 17.60892.5YesYes176
37L:L:F211 R:R:Q115 12.93115.86YesYes107
38R:R:D138 R:R:Y320 10.17748.05YesYes166
39L:L:F211 R:R:C210 24.07252.79YesYes109
40R:R:C131 R:R:C210 25.00967.28YesYes199
41R:R:C131 R:R:T199 14.34063.38YesNo194
42R:R:I208 R:R:T199 12.89651.52NoNo044
43L:L:Y208 R:R:Y139 33.20928.94YesNo005
44R:R:L212 R:R:Y139 26.27313.52NoNo045
45R:R:F143 R:R:M142 25.25163.73YesNo067
46R:R:F143 R:R:V230 20.48165.24YesNo065
47L:L:Y208 R:R:V230 24.79455.05YesNo005
48R:R:I178 R:R:M151 12.11312.92YesNo566
49R:R:M151 R:R:V154 10.92253.04NoNo066
50R:R:V280 R:R:Y246 28.54292.52NoYes088
51R:R:I243 R:R:V280 29.23421.54NoNo058
52R:R:I243 R:R:V239 31.79581.54NoNo056
53R:R:F283 R:R:V239 35.26772.62YesNo096
54R:R:S153 R:R:Y246 14.820611.45NoYes798
55R:R:C245 R:R:S153 14.44433.44NoNo079
56R:R:C245 R:R:V154 12.25521.71NoNo076
57R:R:C245 R:R:Y157 11.50639.41NoNo077
58R:R:M249 R:R:Y246 22.92424.79NoYes088
59R:R:M249 R:R:V160 21.8226.09NoNo088
60R:R:L253 R:R:V160 20.82342.98NoNo088
61R:R:F214 R:R:L212 24.85982.44YesNo664
62R:R:F214 R:R:M226 35.76313.73YesNo665
63R:R:M226 R:R:V230 37.77943.04NoNo055
64R:R:I294 R:R:K227 15.40822.91NoYes054
65L:L:R213 R:R:Y219 15.584924.69NoNo001
66R:R:F214 R:R:Y219 27.49836.19YesNo061
67R:R:F214 R:R:W222 27.76711YesYes067
68R:R:F225 R:R:W222 11.94412NoYes047
69R:R:H291 R:R:W287 14.85145.29NoYes288
70R:R:L253 R:R:L259 11.70214.15NoYes883
71R:R:N322 R:R:N326 38.02526.81YesYes299
72R:R:N322 R:R:W287 33.56254.52YesYes298
73R:R:I135 R:R:Y139 16.45672.42NoNo045
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Y313 R:R:Y66 4.96 1 Yes Yes 4 6 1 2
R:R:I316 R:R:Y66 2.42 1 Yes Yes 5 6 1 2
R:R:Q115 R:R:T111 5.67 1 Yes Yes 7 7 1 1
R:R:T111 R:R:V134 4.76 1 Yes Yes 7 6 1 1
R:R:D138 R:R:T111 15.9 1 Yes Yes 6 7 1 1
R:R:T111 R:R:Y320 2.5 1 Yes Yes 7 6 1 2
L:L:F211 R:R:T111 2.59 1 Yes Yes 0 7 0 1
R:R:F114 R:R:W124 7.02 1 No Yes 5 8 2 2
R:R:F114 R:R:L130 7.31 1 No Yes 5 5 2 2
R:R:F114 R:R:V134 5.24 1 No Yes 5 6 2 1
R:R:D138 R:R:Q115 2.61 1 Yes Yes 6 7 1 1
R:R:I316 R:R:Q115 2.74 1 Yes Yes 5 7 1 1
R:R:Q115 R:R:Y320 12.4 1 Yes Yes 7 6 1 2
L:L:F211 R:R:Q115 5.86 1 Yes Yes 0 7 0 1
R:R:Y119 R:R:Y313 13.9 0 No Yes 4 4 2 1
R:R:L130 R:R:W124 5.69 1 Yes Yes 5 8 2 2
R:R:C131 R:R:W124 3.92 1 Yes Yes 9 8 2 2
R:R:C210 R:R:W124 2.61 1 Yes Yes 9 8 1 2
R:R:L130 R:R:V134 2.98 1 Yes Yes 5 6 2 1
R:R:C131 R:R:C210 7.28 1 Yes Yes 9 9 2 1
L:L:F211 R:R:V134 3.93 1 Yes Yes 0 6 0 1
R:R:I135 R:R:Y139 2.42 1 No No 4 5 1 1
R:R:C210 R:R:I135 3.27 1 Yes No 9 4 1 1
L:L:F211 R:R:I135 7.54 1 Yes No 0 4 0 1
R:R:D138 R:R:Y320 8.05 1 Yes Yes 6 6 1 2
L:L:F211 R:R:D138 2.39 1 Yes Yes 0 6 0 1
R:R:L212 R:R:Y139 3.52 6 No No 4 5 2 1
L:L:Y208 R:R:Y139 8.94 0 Yes No 0 5 0 1
R:R:F143 R:R:M142 3.73 0 Yes No 6 7 2 1
R:R:M142 R:R:W287 3.49 0 No Yes 7 8 1 2
L:L:Y208 R:R:M142 8.38 0 Yes No 0 7 0 1
R:R:F143 R:R:V230 5.24 0 Yes No 6 5 2 1
R:R:E209 R:R:K200 8.1 9 No Yes 3 2 1 1
R:R:K200 R:R:Q213 8.14 9 Yes No 2 4 1 2
R:R:D216 R:R:K200 2.77 0 No Yes 2 2 2 1
L:L:R213 R:R:K200 4.95 9 No Yes 0 2 0 1
R:R:E209 R:R:S211 4.31 9 No No 3 4 1 2
L:L:R213 R:R:E209 4.65 9 No No 0 3 0 1
L:L:F211 R:R:C210 2.79 1 Yes Yes 0 9 0 1
R:R:F214 R:R:L212 2.44 6 Yes No 6 4 2 2
R:R:L212 R:R:M226 2.83 6 No No 4 5 2 2
R:R:F214 R:R:Y219 6.19 6 Yes No 6 1 2 1
R:R:D223 R:R:F214 3.58 0 No Yes 4 6 2 2
R:R:F214 R:R:M226 3.73 6 Yes No 6 5 2 2
R:R:D216 R:R:Y219 3.45 0 No No 2 1 2 1
L:L:R213 R:R:Y219 24.69 9 No No 0 1 0 1
R:R:D223 R:R:K227 12.44 0 No Yes 4 4 2 1
R:R:M226 R:R:V230 3.04 6 No No 5 5 2 1
R:R:I294 R:R:K227 2.91 0 No Yes 5 4 1 1
R:R:A298 R:R:K227 3.21 0 No Yes 4 4 2 1
L:L:L212 R:R:K227 4.23 0 No Yes 0 4 0 1
L:L:Y208 R:R:V230 5.05 0 Yes No 0 5 0 1
R:R:I290 R:R:I294 5.89 1 Yes No 6 5 2 1
R:R:I290 R:R:Y312 2.42 1 Yes Yes 6 4 2 1
R:R:I290 R:R:I316 2.94 1 Yes Yes 6 5 2 1
R:R:E297 R:R:F293 9.33 0 No No 5 5 1 2
R:R:F293 R:R:Y312 8.25 0 No Yes 5 4 2 1
L:L:Y208 R:R:I294 2.42 0 Yes No 0 5 0 1
L:L:R214 R:R:E297 10.47 0 No No 0 5 0 1
R:R:L309 R:R:Y313 4.69 0 No Yes 4 4 1 1
L:L:R214 R:R:L309 6.07 0 No No 0 4 0 1
R:R:Y312 R:R:Y313 8.94 1 Yes Yes 4 4 1 1
R:R:I316 R:R:Y312 6.04 1 Yes Yes 5 4 1 1
L:L:G209 R:R:Y312 2.9 1 No Yes 0 4 0 1
L:L:R214 R:R:Y312 19.55 0 No Yes 0 4 0 1
R:R:I316 R:R:Y313 2.42 1 Yes Yes 5 4 1 1
L:L:G210 R:R:Y313 2.9 0 No Yes 0 4 0 1
R:R:I316 R:R:Y320 2.42 1 Yes Yes 5 6 1 2
L:L:G209 R:R:I316 3.53 1 No Yes 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8F7W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.39
Number of Linked Nodes 266
Number of Links 311
Number of Hubs 47
Number of Links mediated by Hubs 170
Number of Communities 10
Number of Nodes involved in Communities 61
Number of Links involved in Communities 86
Path Summary
Number Of Nodes in MetaPath 74
Number Of Links MetaPath 73
Number of Shortest Paths 62754
Length Of Smallest Path 3
Average Path Length 13.2315
Length of Longest Path 29
Minimum Path Strength 1.22
Average Path Strength 4.81345
Maximum Path Strength 15.44
Minimum Path Correlation 0.7
Average Path Correlation 0.91831
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 45.8928
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.8084
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41145
Sequence
>8F7W_nogp_Chain_R
AIPVIITAV YSVVFVVGL VGNSLVMFV IIRYTKMKT ATNIYIFNL 
ALADALVTT TMPFQSTVY LMNSWPFGD VLCKIVISI DYYNMFTSI 
FTLTMMSVD RYIAVCHPV KALDFRTPL KAKIINICI WLLSSSVGI 
SAIVLGGTK VREDVDVIE CSLQFPDDD YSWWDLFMK ICVFIFAFV 
IPVLIIIVC YTLMILRLK SVRLLSGSR EKDRNLRRI TRLVLVVVA 
VFVVCWTPI HIFILVEAL GSTSHSTAA LSSYYFCIA LGYTNSSLN 
PILYAFLDE NFKRCFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainL
ProteinDynorphin
UniProtP01213
Sequence
>8F7W_nogp_Chain_L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4DJHAPeptideOpioidκHomo sapiensJDTic--2.92012-03-21doi.org/10.1038/nature10939
6B73APeptideOpioidκHomo sapiensMP1104--3.12018-01-17doi.org/10.1016/j.cell.2017.12.011
6VI4APeptideOpioidκHomo sapiensJDTic--3.32020-03-18doi.org/10.1038/s41467-020-14889-7
8F7WAPeptideOpioidκHomo sapiensDynorphin-Gi1/β1/γ23.192022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7W (No Gprot) APeptideOpioidκHomo sapiensDynorphin-3.192022-12-14doi.org/10.1016/j.cell.2022.12.026
7YITAPeptideOpioidκHomo sapiensNalfurafine--3.32023-04-12doi.org/10.1038/s41467-023-37041-7
8DZPAPeptideOpioidκHomo sapiensmomSalB-Gi1/β1/γ22.712023-05-03doi.org/10.1038/s41586-023-06030-7
8DZP (No Gprot) APeptideOpioidκHomo sapiensmomSalB-2.712023-05-03doi.org/10.1038/s41586-023-06030-7
8DZQAPeptideOpioidκHomo sapiensmomSalB-Go/β1/γ22.822023-05-03doi.org/10.1038/s41586-023-06030-7
8DZQ (No Gprot) APeptideOpioidκHomo sapiensmomSalB-2.822023-05-03doi.org/10.1038/s41586-023-06030-7
8DZRAPeptideOpioidκHomo sapiensGR89,696-chim(NtGi2-Gt3)/β1/γ22.612023-05-03doi.org/10.1038/s41586-023-06030-7
8DZR (No Gprot) APeptideOpioidκHomo sapiensGR89,696-2.612023-05-03doi.org/10.1038/s41586-023-06030-7
8DZSAPeptideOpioidκHomo sapiensGR89,696-chim(NtGi2-Gz)/β1/γ22.652023-05-03doi.org/10.1038/s41586-023-06030-7
8DZS (No Gprot) APeptideOpioidκHomo sapiensGR89,696-2.652023-05-03doi.org/10.1038/s41586-023-06030-7
7Y1FAPeptideOpioidκHomo sapiensDynorphin-Gi1/β1/γ23.32023-05-24doi.org/10.1093/procel/pwac033
7Y1F (No Gprot) APeptideOpioidκHomo sapiensDynorphin-3.32023-05-24doi.org/10.1093/procel/pwac033
9MQKAPeptideOpioidκHomo sapiensIsoquinuclidine--3.182025-02-12doi.org/10.1101/2025.01.09.632033
9MQLAPeptideOpioidκHomo sapiensIsoquinuclidine--2.962025-02-12doi.org/10.1101/2025.01.09.632033
8FEGAPeptideOpioidκHomo sapiens(DNCP)-β-Naloxamine-Gi1/β1/γ22.542023-12-06doi.org/10.1038/s41467-023-43718-w
8FEG (No Gprot) APeptideOpioidκHomo sapiens(DNCP)-β-Naloxamine-2.542023-12-06doi.org/10.1038/s41467-023-43718-w
8VVEAPeptideOpioidκHomo sapiensnorBNI-Gi1/β1/γ23.32025-01-15doi.org/10.1038/s41589-024-01812-0
8VVE (No Gprot) APeptideOpioidκHomo sapiensnorBNI-3.32025-01-15doi.org/10.1038/s41589-024-01812-0
8VVFAPeptideOpioidκHomo sapiensJDTic-Gi1/β1/γ232025-01-15doi.org/10.1038/s41589-024-01812-0
8VVF (No Gprot) APeptideOpioidκHomo sapiensJDTic-32025-01-15doi.org/10.1038/s41589-024-01812-0
8VVGAPeptideOpioidκHomo sapiensGB18-Gi1/β1/γ23.32025-01-15doi.org/10.1038/s41589-024-01812-0
8VVG (No Gprot) APeptideOpioidκHomo sapiensGB18-3.32025-01-15doi.org/10.1038/s41589-024-01812-0
9D61APeptideOpioidκHomo sapiensJDTic-Gi1/β1/γ23.582025-01-15doi.org/10.1038/s41589-024-01812-0
9D61 (No Gprot) APeptideOpioidκHomo sapiensJDTic-3.582025-01-15doi.org/10.1038/s41589-024-01812-0
9V6OAPeptideOpioidκHomo sapiensNalfurafine-Gi1/β1/γ22.762025-11-1910.1038/s41467-025-64882-1
9V6O (No Gprot) APeptideOpioidκHomo sapiensNalfurafine-2.762025-11-1910.1038/s41467-025-64882-1
9W49APeptideOpioidκHomo sapiensU-50488H-Gi1/β1/γ22.92025-11-1910.1038/s41467-025-64882-1
9W49 (No Gprot) APeptideOpioidκHomo sapiensU-50488H-2.92025-11-1910.1038/s41467-025-64882-1
9L60APeptideOpioidκHomo sapiensDynorphinMPAM-15Gi1/β1/γ22.92025-12-31To be published
9L60 (No Gprot) APeptideOpioidκHomo sapiensDynorphinMPAM-152.92025-12-31To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8F7W_nogp.zip



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