psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q115	6.05	Yes	Yes	1	0	7
2	L:L:?1	R:R:V118	4.83	Yes	No	1	0	5
3	L:L:?1	R:R:I135	4.63	Yes	No	0	0	4
4	L:L:?1	R:R:D138	23.78	Yes	No	1	0	6
5	L:L:?1	R:R:Y139	6.85	Yes	Yes	1	0	5
6	L:L:?1	R:R:M142	8.26	Yes	No	1	0	7
7	L:L:?1	R:R:K227	6.41	Yes	Yes	1	0	4
8	L:L:?1	R:R:I290	2.78	Yes	No	1	0	6
9	L:L:?1	R:R:H291	4.17	Yes	Yes	1	0	8
10	L:L:?1	R:R:I294	4.63	Yes	No	1	0	5
11	L:L:?1	R:R:Y312	3.04	Yes	No	1	0	4
12	L:L:?1	R:R:I316	7.41	Yes	Yes	1	0	5
13	L:L:?1	R:R:Y320	12.17	Yes	Yes	1	0	6
14	R:R:I58	R:R:P59	3.39	No	No	0	4	4
15	R:R:P59	R:R:Y119	2.78	No	Yes	0	4	4
16	R:R:T63	R:R:Y119	2.5	No	Yes	0	5	4
17	R:R:M112	R:R:Y66	14.37	Yes	Yes	1	7	6
18	R:R:Q115	R:R:Y66	4.51	Yes	Yes	1	7	6
19	R:R:S116	R:R:Y66	2.54	No	Yes	0	6	6
20	R:R:Y320	R:R:Y66	6.95	Yes	Yes	1	6	6
21	R:R:S324	R:R:V69	3.23	Yes	No	0	7	7
22	R:R:F70	R:R:L74	8.53	Yes	No	1	7	6
23	R:R:F70	R:R:T109	2.59	Yes	No	1	7	6
24	R:R:F70	R:R:M112	12.44	Yes	Yes	1	7	7
25	R:R:F70	R:R:P113	10.11	Yes	No	1	7	8
26	R:R:L74	R:R:T109	4.42	No	No	1	6	6
27	R:R:G76	R:R:L79	5.13	No	No	0	7	6
28	R:R:N77	R:R:V80	2.96	Yes	Yes	3	9	9
29	R:R:A102	R:R:N77	3.13	No	Yes	0	8	9
30	R:R:D105	R:R:N77	2.69	Yes	Yes	3	9	9
31	R:R:A106	R:R:N77	3.13	No	Yes	0	8	9
32	R:R:N77	R:R:P327	9.77	Yes	No	3	9	9
33	R:R:P327	R:R:V80	3.53	No	Yes	3	9	9
34	R:R:F99	R:R:M81	6.22	Yes	No	0	5	7
35	R:R:A102	R:R:M81	3.22	No	No	0	8	7
36	R:R:V83	R:R:Y87	3.79	No	No	0	8	5
37	R:R:F337	R:R:V83	2.62	Yes	No	0	8	8
38	R:R:I84	R:R:M90	4.37	No	No	6	7	7
39	R:R:F99	R:R:I84	3.77	Yes	No	6	5	7
40	R:R:F337	R:R:I84	3.77	Yes	No	0	8	7
41	R:R:F337	R:R:T88	6.49	Yes	No	0	8	6
42	R:R:C340	R:R:T88	3.38	No	No	0	6	6
43	R:R:I96	R:R:M90	2.92	Yes	No	0	5	7
44	R:R:F99	R:R:M90	7.46	Yes	No	6	5	7
45	R:R:K91	R:R:P172	10.04	No	No	0	7	2
46	R:R:T92	R:R:T94	3.14	No	No	0	7	8
47	R:R:N95	R:R:T92	5.85	No	No	0	7	7
48	R:R:I96	R:R:Y97	2.42	Yes	No	0	5	7
49	R:R:A175	R:R:I96	3.25	No	Yes	0	7	5
50	R:R:I96	R:R:K176	7.27	Yes	No	0	5	4
51	R:R:I96	R:R:N179	4.25	Yes	Yes	0	5	7
52	R:R:M152	R:R:Y97	3.59	Yes	No	0	8	7
53	R:R:I178	R:R:Y97	2.42	No	No	0	6	7
54	R:R:I98	R:R:Y330	6.04	No	No	0	8	9
55	R:R:F337	R:R:I98	3.77	Yes	No	0	8	8
56	R:R:F99	R:R:L103	2.44	Yes	No	0	5	6
57	R:R:N100	R:R:T148	4.39	No	No	0	9	7
58	R:R:N100	R:R:N179	14.98	No	Yes	7	9	7
59	R:R:N100	R:R:W183	9.04	No	Yes	7	9	9
60	R:R:L101	R:R:S145	3	No	No	0	9	9
61	R:R:L101	R:R:T148	7.37	No	No	0	9	7
62	R:R:L101	R:R:L149	4.15	No	No	0	9	8
63	R:R:L103	R:R:L107	4.15	No	No	0	6	6
64	R:R:A104	R:R:N141	3.13	No	No	0	8	8
65	R:R:D105	R:R:S323	8.83	Yes	No	0	9	8
66	R:R:D105	R:R:N326	4.04	Yes	No	0	9	9
67	R:R:D105	R:R:P327	3.22	Yes	No	3	9	9
68	R:R:N141	R:R:V108	11.82	No	No	0	8	7
69	R:R:V108	R:R:Y320	3.79	No	Yes	0	7	6
70	R:R:S323	R:R:V108	3.23	No	No	0	8	7
71	R:R:M112	R:R:T109	3.01	Yes	No	1	7	6
72	R:R:F114	R:R:T111	2.59	Yes	Yes	1	5	7
73	R:R:T111	R:R:V134	3.17	Yes	No	1	7	6
74	R:R:I137	R:R:T111	3.04	No	Yes	0	5	7
75	R:R:T111	R:R:Y320	4.99	Yes	Yes	1	7	6
76	R:R:M112	R:R:P113	3.35	Yes	No	1	7	8
77	R:R:M112	R:R:Y320	11.97	Yes	Yes	1	7	6
78	R:R:F114	R:R:F126	6.43	Yes	Yes	1	5	7
79	R:R:F114	R:R:L130	3.65	Yes	Yes	1	5	5
80	R:R:F114	R:R:V134	3.93	Yes	No	1	5	6
81	R:R:Q115	R:R:V118	4.3	Yes	No	1	7	5
82	R:R:I316	R:R:Q115	5.49	Yes	Yes	1	5	7
83	R:R:F126	R:R:T117	2.59	Yes	No	0	7	4
84	R:R:V118	R:R:W124	3.68	No	Yes	1	5	8
85	R:R:Y119	R:R:Y313	10.92	Yes	No	0	4	4
86	R:R:M121	R:R:S123	3.07	No	No	0	4	4
87	R:R:S123	R:R:V207	4.85	No	No	0	4	3
88	R:R:F126	R:R:W124	8.02	Yes	Yes	1	7	8
89	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
90	R:R:T199	R:R:W124	6.06	Yes	Yes	1	4	8
91	R:R:I208	R:R:W124	18.79	No	Yes	1	4	8
92	R:R:C210	R:R:W124	5.22	No	Yes	1	9	8
93	R:R:F126	R:R:L130	4.87	Yes	Yes	1	7	5
94	R:R:D128	R:R:T199	5.78	No	Yes	0	2	4
95	R:R:I133	R:R:L130	2.85	No	Yes	0	5	5
96	R:R:C131	R:R:C210	7.28	No	No	0	9	9
97	R:R:I194	R:R:K132	4.36	Yes	No	0	4	6
98	R:R:I194	R:R:S136	3.1	Yes	No	0	4	5
99	R:R:D138	R:R:Y139	6.9	No	Yes	1	6	5
100	R:R:M142	R:R:Y139	3.59	No	Yes	1	7	5
101	R:R:V189	R:R:Y139	2.52	Yes	Yes	0	5	5
102	R:R:A193	R:R:Y139	2.67	No	Yes	0	5	5
103	R:R:W183	R:R:Y140	12.54	Yes	No	0	9	5
104	R:R:S186	R:R:Y140	3.82	No	No	0	8	5
105	R:R:S187	R:R:Y140	6.36	No	No	0	4	5
106	R:R:F143	R:R:F147	4.29	No	No	0	6	6
107	R:R:F143	R:R:V189	14.42	No	Yes	0	6	5
108	R:R:F143	R:R:V230	2.62	No	No	0	6	5
109	R:R:T144	R:R:W183	10.92	No	Yes	0	7	9
110	R:R:S186	R:R:T144	6.4	No	No	0	8	7
111	R:R:I146	R:R:P238	3.39	No	No	0	7	9
112	R:R:F283	R:R:I146	2.51	Yes	No	0	9	7
113	R:R:F147	R:R:I182	2.51	No	No	0	6	7
114	R:R:F147	R:R:L185	6.09	No	No	0	6	4
115	R:R:P238	R:R:T150	3.5	No	No	0	9	7
116	R:R:I241	R:R:T150	3.04	No	No	0	6	7
117	R:R:I242	R:R:T150	6.08	No	No	0	8	7
118	R:R:M151	R:R:V154	3.04	No	No	0	6	6
119	R:R:I178	R:R:M151	4.37	No	No	0	6	6
120	R:R:M152	R:R:R156	4.96	Yes	No	0	8	9
121	R:R:M152	R:R:Y330	3.59	Yes	No	0	8	9
122	R:R:I242	R:R:S153	9.29	No	No	8	8	9
123	R:R:S153	R:R:Y246	15.26	No	Yes	8	9	8
124	R:R:D155	R:R:R170	16.68	No	No	0	8	6
125	R:R:R156	R:R:Y246	3.09	No	Yes	0	9	8
126	R:R:C161	R:R:Y157	9.41	No	Yes	9	7	7
127	R:R:H162	R:R:Y157	7.62	Yes	Yes	9	6	7
128	R:R:C245	R:R:Y157	6.72	No	Yes	0	7	7
129	R:R:L248	R:R:Y157	7.03	No	Yes	0	4	7
130	R:R:H162	R:R:I158	3.98	Yes	No	0	6	5
131	R:R:F169	R:R:I158	5.02	No	No	0	4	5
132	R:R:A159	R:R:R170	5.53	No	No	0	8	6
133	R:R:M249	R:R:V160	10.65	No	No	0	8	8
134	R:R:R252	R:R:V160	2.62	No	No	0	5	8
135	R:R:L253	R:R:V160	2.98	No	No	0	8	8
136	R:R:C161	R:R:H162	10.32	No	Yes	9	7	6
137	R:R:H162	R:R:K165	3.93	Yes	No	0	6	4
138	R:R:K165	R:R:V164	3.04	No	No	0	4	5
139	R:R:A166	R:R:R170	2.77	No	No	0	5	6
140	R:R:F169	R:R:K174	2.48	No	No	0	4	5
141	R:R:P172	R:R:T171	3.5	No	No	0	2	7
142	R:R:K174	R:R:T171	3	No	No	0	5	7
143	R:R:I177	R:R:L173	2.85	No	No	0	3	4
144	R:R:I182	R:R:N179	2.83	No	Yes	0	7	7
145	R:R:N179	R:R:W183	9.04	Yes	Yes	7	7	9
146	R:R:S188	R:R:V189	3.23	No	Yes	0	4	5
147	R:R:S192	R:R:V189	3.23	No	Yes	0	7	5
148	R:R:L196	R:R:L212	2.77	No	Yes	0	4	4
149	R:R:G197	R:R:Q213	3.29	No	No	0	4	4
150	R:R:G198	R:R:Q213	4.93	No	No	0	4	4
151	R:R:I208	R:R:T199	6.08	No	Yes	1	4	4
152	R:R:C210	R:R:T199	3.38	No	Yes	1	9	4
153	R:R:I208	R:R:V201	3.07	No	No	0	4	2
154	R:R:D204	R:R:R202	7.15	No	No	0	2	2
155	R:R:R202	R:R:V207	3.92	No	No	0	2	3
156	R:R:E209	R:R:R202	11.63	No	No	0	3	2
157	R:R:D204	R:R:V205	8.76	No	No	0	2	1
158	R:R:D204	R:R:H304	7.56	No	No	0	2	1
159	R:R:V205	R:R:V207	6.41	No	No	0	1	3
160	R:R:F214	R:R:L212	15.83	Yes	Yes	2	6	4
161	R:R:D223	R:R:L212	4.07	No	Yes	2	4	4
162	R:R:L212	R:R:M226	2.83	Yes	No	0	4	5
163	R:R:P215	R:R:Q213	3.16	No	No	0	5	4
164	R:R:D223	R:R:F214	10.75	No	Yes	2	4	6
165	R:R:P215	R:R:Y219	2.78	No	Yes	0	5	1
166	R:R:D217	R:R:D218	9.31	No	No	2	1	4
167	R:R:D217	R:R:Y219	19.54	No	Yes	2	1	1
168	R:R:D218	R:R:Y219	8.05	No	Yes	2	4	1
169	R:R:K227	R:R:V230	3.04	Yes	No	0	4	5
170	R:R:I294	R:R:K227	7.27	No	Yes	1	5	4
171	R:R:F231	R:R:H291	9.05	No	Yes	0	5	8
172	R:R:F231	R:R:L295	8.53	No	No	0	5	5
173	R:R:F233	R:R:I232	3.77	No	No	0	4	5
174	R:R:I232	R:R:V236	4.61	No	No	0	5	4
175	R:R:F233	R:R:I237	2.51	No	No	0	4	5
176	R:R:A234	R:R:H291	4.39	No	Yes	0	6	8
177	R:R:F235	R:R:V239	5.24	Yes	No	0	8	6
178	R:R:F235	R:R:F283	5.36	Yes	Yes	1	8	9
179	R:R:F235	R:R:W287	3.01	Yes	No	1	8	8
180	R:R:F235	R:R:T288	7.78	Yes	Yes	0	8	5
181	R:R:F235	R:R:H291	19.23	Yes	Yes	1	8	8
182	R:R:I237	R:R:P238	3.39	No	No	0	5	9
183	R:R:I242	R:R:Y246	2.42	No	Yes	8	8	8
184	R:R:L248	R:R:V244	2.98	No	No	0	4	4
185	R:R:V276	R:R:Y246	7.57	No	Yes	0	8	8
186	R:R:V280	R:R:Y246	2.52	No	Yes	0	8	8
187	R:R:I250	R:R:M249	2.92	No	No	0	5	8
188	R:R:I250	R:R:T273	6.08	No	No	0	5	6
189	R:R:L253	R:R:L259	2.77	No	No	0	8	3
190	R:R:K254	R:R:L269	7.05	No	No	0	4	6
191	R:R:L259	R:R:V256	4.47	No	No	0	3	6
192	R:R:G261	R:R:K265	6.97	No	No	0	3	4
193	R:R:E264	R:R:R267	13.96	No	No	0	3	4
194	R:R:L269	R:R:T273	2.95	No	No	0	6	6
195	R:R:R270	R:R:R274	3.2	No	No	0	5	6
196	R:R:E335	R:R:R271	10.47	No	No	0	4	7
197	R:R:L275	R:R:L333	6.92	No	Yes	4	8	7
198	R:R:F283	R:R:V284	2.62	Yes	No	0	9	6
199	R:R:F283	R:R:W287	9.02	Yes	No	1	9	8
200	R:R:T288	R:R:V284	3.17	Yes	No	0	5	6
201	R:R:C286	R:R:N322	6.3	No	Yes	0	8	9
202	R:R:N322	R:R:W287	11.3	Yes	No	0	9	8
203	R:R:I292	R:R:T288	3.04	No	Yes	0	5	5
204	R:R:H291	R:R:I290	2.65	Yes	No	1	8	6
205	R:R:E297	R:R:F293	16.32	No	Yes	0	5	5
206	R:R:A308	R:R:F293	2.77	No	Yes	0	3	5
207	R:R:F293	R:R:Y312	8.25	Yes	No	0	5	4
208	R:R:E297	R:R:T302	14.11	No	No	0	5	1
209	R:R:H304	R:R:S303	4.18	No	No	0	1	1
210	R:R:L309	R:R:Y313	7.03	No	No	0	4	4
211	R:R:I316	R:R:Y312	10.88	Yes	No	1	5	4
212	R:R:F314	R:R:L318	7.31	No	No	0	5	8
213	R:R:I316	R:R:Y320	2.42	Yes	Yes	1	5	6
214	R:R:G319	R:R:N322	5.09	No	Yes	0	7	9
215	R:R:S324	R:R:T321	3.2	Yes	No	5	7	5
216	R:R:L325	R:R:T321	2.95	No	No	5	6	5
217	R:R:N322	R:R:S323	4.47	Yes	No	0	9	8
218	R:R:L325	R:R:S324	3	No	Yes	5	6	7
219	R:R:F332	R:R:I328	6.28	No	No	0	6	7
220	R:R:L329	R:R:L333	5.54	No	Yes	4	8	7
221	R:R:D334	R:R:N336	5.39	No	No	0	8	6
222	R:R:E335	R:R:K338	2.7	No	No	0	4	8
223	R:R:N268	R:R:R271	2.41	No	No	0	5	7
224	R:R:M249	R:R:Y246	2.39	No	Yes	0	8	8
225	R:R:D266	R:R:R267	2.38	No	No	0	3	4
226	R:R:Q115	R:R:Y313	2.25	Yes	No	0	7	4
227	R:R:F214	R:R:Y219	2.06	Yes	Yes	2	6	1
228	R:R:C315	R:R:P289	1.88	No	No	0	7	9
229	R:R:G73	R:R:S324	1.86	No	Yes	0	8	7
230	R:R:G190	R:R:S136	1.86	No	No	0	6	5
231	R:R:G73	R:R:V72	1.84	No	No	0	8	5
232	R:R:G76	R:R:V75	1.84	No	No	0	7	4
233	R:R:A175	R:R:A93	1.79	No	No	0	7	6
234	R:R:P289	R:R:T288	1.75	No	Yes	0	9	5
235	R:R:G197	R:R:K132	1.74	No	No	0	4	6
236	R:R:G198	R:R:K132	1.74	No	No	0	4	6
237	R:R:C245	R:R:S153	1.72	No	No	0	7	9
238	R:R:A193	R:R:S136	1.71	No	No	0	5	5
239	R:R:G300	R:R:L299	1.71	No	No	0	2	4
240	R:R:A308	R:R:S305	1.71	No	No	0	3	3
241	R:R:G319	R:R:L318	1.71	No	No	0	7	8
242	R:R:A331	R:R:V80	1.7	No	Yes	0	7	9
243	R:R:K200	R:R:P215	1.67	No	No	0	2	5
244	R:R:S310	R:R:S311	1.63	No	No	0	2	4
245	R:R:A57	R:R:I58	1.62	No	No	0	4	4
246	R:R:S67	R:R:V71	1.62	No	No	0	4	5
247	R:R:A298	R:R:K227	1.61	No	Yes	0	4	4
248	R:R:V278	R:R:V282	1.6	No	No	0	5	7
249	R:R:T302	R:R:V296	1.59	No	No	0	1	4
250	R:R:A298	R:R:L224	1.58	No	No	0	4	3
251	R:R:I61	R:R:V60	1.54	No	No	0	5	5
252	R:R:I61	R:R:V65	1.54	No	No	0	5	5
253	R:R:A93	R:R:D155	1.54	No	No	0	6	8
254	R:R:I194	R:R:V195	1.54	Yes	No	0	4	4
255	R:R:I243	R:R:V239	1.54	No	No	0	5	6
256	R:R:I243	R:R:V280	1.54	No	No	0	5	8
257	R:R:H162	R:R:P163	1.53	Yes	No	0	6	8
258	R:R:I243	R:R:T247	1.52	No	No	0	5	4
259	R:R:M152	R:R:T94	1.51	Yes	No	0	8	8
260	R:R:K89	R:R:T88	1.5	No	No	0	5	6
261	R:R:L79	R:R:V80	1.49	No	Yes	0	6	9
262	R:R:L130	R:R:V129	1.49	Yes	No	0	5	1
263	R:R:L149	R:R:V279	1.49	No	Yes	0	8	8
264	R:R:L240	R:R:V244	1.49	No	No	0	3	4
265	R:R:L275	R:R:V276	1.49	No	No	0	8	8
266	R:R:L275	R:R:V279	1.49	No	Yes	4	8	8
267	R:R:L333	R:R:V278	1.49	Yes	No	0	7	5
268	R:R:L329	R:R:V279	1.49	No	Yes	4	8	8
269	R:R:L333	R:R:V279	1.49	Yes	Yes	4	7	8
270	R:R:I191	R:R:I194	1.47	No	Yes	0	4	4
271	R:R:I250	R:R:I272	1.47	No	No	0	5	7
272	R:R:N336	R:R:T94	1.46	No	No	0	6	8
273	R:R:I328	R:R:L325	1.43	No	No	0	7	6
274	R:R:I328	R:R:L329	1.43	No	No	0	7	8
275	R:R:C229	R:R:F233	1.4	No	No	0	3	4
276	R:R:L258	R:R:L259	1.38	No	No	0	5	3
277	R:R:P125	R:R:W124	1.35	No	Yes	0	1	8
278	R:R:F214	R:R:S211	1.32	Yes	No	0	6	4
279	R:R:F293	R:R:S311	1.32	Yes	No	0	5	4
280	R:R:F70	R:R:V71	1.31	Yes	No	0	7	5
281	R:R:E264	R:R:N268	1.31	No	No	0	3	5
282	R:R:H304	R:R:L309	1.29	No	No	0	1	4
283	R:R:I85	R:R:R86	1.25	No	No	0	3	5
284	R:R:I62	R:R:Y119	1.21	No	Yes	0	5	4
285	R:R:D168	R:R:F169	1.19	No	No	0	4	4
286	R:R:R86	R:R:Y87	1.03	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.30846	13	1	0
2	R:R:Y66	7.0925	4	1	6
3	R:R:F70	6.996	5	1	7
4	R:R:N77	4.336	5	3	9
5	R:R:V80	2.42	4	3	9
6	R:R:I96	4.022	5	0	5
7	R:R:F99	4.9725	4	6	5
8	R:R:D105	4.695	4	3	9
9	R:R:T111	3.4475	4	1	7
10	R:R:M112	9.028	5	1	7
11	R:R:F114	4.15	4	1	5
12	R:R:Q115	4.52	5	1	7
13	R:R:Y119	4.3525	4	0	4
14	R:R:W124	6.56143	7	1	8
15	R:R:F126	5.4775	4	1	7
16	R:R:L130	3.215	4	1	5
17	R:R:Y139	4.506	5	1	5
18	R:R:M152	3.4125	4	0	8
19	R:R:Y157	7.695	4	9	7
20	R:R:H162	5.476	5	9	6
21	R:R:N179	7.775	4	7	7
22	R:R:W183	10.385	4	7	9
23	R:R:V189	5.85	4	0	5
24	R:R:I194	2.6175	4	0	4
25	R:R:T199	5.325	4	1	4
26	R:R:L212	6.375	4	2	4
27	R:R:F214	7.49	4	2	6
28	R:R:Y219	8.1075	4	2	1
29	R:R:K227	4.5825	4	1	4
30	R:R:F235	8.124	5	1	8
31	R:R:Y246	5.54167	6	8	8
32	R:R:V279	1.49	4	4	8
33	R:R:F283	4.8775	4	1	9
34	R:R:T288	3.935	4	0	5
35	R:R:H291	7.898	5	1	8
36	R:R:F293	7.165	4	0	5
37	R:R:I316	6.55	4	1	5
38	R:R:Y320	7.04833	6	1	6
39	R:R:N322	6.79	4	0	9
40	R:R:S324	2.8225	4	5	7
41	R:R:L333	3.86	4	4	7
42	R:R:F337	4.1625	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q115	54.0887	6.05	Yes	Yes	1	0	7
2	R:R:Q115	R:R:Y313	70.4616	2.25	Yes	No	0	7	4
3	R:R:Y119	R:R:Y313	21.3883	10.92	Yes	No	0	4	4
4	R:R:P59	R:R:Y119	10.9122	2.78	No	Yes	0	4	4
5	L:L:?1	R:R:Y320	64.6647	12.17	Yes	Yes	1	0	6
6	R:R:M112	R:R:Y320	19.98	11.97	Yes	Yes	1	7	6
7	R:R:Y320	R:R:Y66	12.9747	6.95	Yes	Yes	1	6	6
8	R:R:Q115	R:R:Y66	14.592	4.51	Yes	Yes	1	7	6
9	L:L:?1	R:R:H291	100	4.17	Yes	Yes	1	0	8
10	R:R:F235	R:R:H291	99.1005	19.23	Yes	Yes	1	8	8
11	R:R:F235	R:R:V239	90.0509	5.24	Yes	No	0	8	6
12	R:R:I243	R:R:V239	89.4421	1.54	No	No	0	5	6
13	R:R:I243	R:R:V280	88.4336	1.54	No	No	0	5	8
14	R:R:V280	R:R:Y246	87.9793	2.52	No	Yes	0	8	8
15	R:R:V276	R:R:Y246	48.8824	7.57	No	Yes	0	8	8
16	R:R:L275	R:R:V276	46.9744	1.49	No	No	0	8	8
17	R:R:L275	R:R:L333	23.2328	6.92	No	Yes	4	8	7
18	R:R:L329	R:R:L333	17.1634	5.54	No	Yes	4	8	7
19	R:R:I328	R:R:L329	36.262	1.43	No	No	0	7	8
20	R:R:I328	R:R:L325	27.3033	1.43	No	No	0	7	6
21	R:R:L325	R:R:S324	18.2355	3	No	Yes	5	6	7
22	R:R:L275	R:R:V279	21.879	1.49	No	Yes	4	8	8
23	R:R:L329	R:R:V279	23.2055	1.49	No	Yes	4	8	8
24	R:R:F70	R:R:M112	11.2212	12.44	Yes	Yes	1	7	7
25	R:R:V108	R:R:Y320	54.9791	3.79	No	Yes	0	7	6
26	R:R:S323	R:R:V108	52.0353	3.23	No	No	0	8	7
27	R:R:D105	R:R:S323	55.4516	8.83	Yes	No	0	9	8
28	R:R:D105	R:R:N77	37.3614	2.69	Yes	Yes	3	9	9
29	R:R:N77	R:R:V80	16.2548	2.96	Yes	Yes	3	9	9
30	R:R:L79	R:R:V80	16.809	1.49	No	Yes	0	6	9
31	R:R:G76	R:R:L79	11.2212	5.13	No	No	0	7	6
32	R:R:D105	R:R:P327	14.1559	3.22	Yes	No	3	9	9
33	R:R:P327	R:R:V80	11.6664	3.53	No	Yes	3	9	9
34	R:R:A102	R:R:N77	27.9938	3.13	No	Yes	0	8	9
35	R:R:A102	R:R:M81	27.0398	3.22	No	No	0	8	7
36	R:R:F99	R:R:M81	26.2039	6.22	Yes	No	0	5	7
37	L:L:?1	R:R:Y139	86.4256	6.85	Yes	Yes	1	0	5
38	R:R:V189	R:R:Y139	49.5275	2.52	Yes	Yes	0	5	5
39	R:R:F143	R:R:V189	45.984	14.42	No	Yes	0	6	5
40	R:R:F143	R:R:F147	70.9886	4.29	No	No	0	6	6
41	R:R:F147	R:R:I182	68.1719	2.51	No	No	0	6	7
42	R:R:I182	R:R:N179	67.0271	2.83	No	Yes	0	7	7
43	R:R:I96	R:R:N179	51.054	4.25	Yes	Yes	0	5	7
44	R:R:I96	R:R:M90	29.702	2.92	Yes	No	0	5	7
45	R:R:I84	R:R:M90	14.0287	4.37	No	No	6	7	7
46	R:R:F337	R:R:I84	23.0965	3.77	Yes	No	0	8	7
47	R:R:F337	R:R:V83	14.6375	2.62	Yes	No	0	8	8
48	L:L:?1	R:R:K227	31.919	6.41	Yes	Yes	1	0	4
49	R:R:K227	R:R:V230	28.4754	3.04	Yes	No	0	4	5
50	R:R:F143	R:R:V230	27.4941	2.62	No	No	0	6	5
51	R:R:F99	R:R:I84	12.0934	3.77	Yes	No	6	5	7
52	R:R:V83	R:R:Y87	11.0031	3.79	No	No	0	8	5
53	R:R:F337	R:R:T88	11.0031	6.49	Yes	No	0	8	6
54	R:R:S153	R:R:Y246	40.7414	15.26	No	Yes	8	9	8
55	R:R:C245	R:R:S153	44.3304	1.72	No	No	0	7	9
56	R:R:C245	R:R:Y157	41.8499	6.72	No	Yes	0	7	7
57	R:R:H162	R:R:Y157	29.0751	7.62	Yes	Yes	9	6	7
58	R:R:H162	R:R:I158	18.708	3.98	Yes	No	0	6	5
59	R:R:F169	R:R:I158	16.0458	5.02	No	No	0	4	5
60	R:R:F169	R:R:K174	10.6669	2.48	No	No	0	4	5
61	R:R:R156	R:R:Y246	37.0616	3.09	No	Yes	0	9	8
62	R:R:M152	R:R:R156	35.8986	4.96	Yes	No	0	8	9
63	R:R:M152	R:R:T94	11.9389	1.51	Yes	No	0	8	8
64	R:R:I96	R:R:Y97	29.4021	2.42	Yes	No	0	5	7
65	R:R:A175	R:R:I96	17.6813	3.25	No	Yes	0	7	5
66	R:R:M152	R:R:Y330	11.1757	3.59	Yes	No	0	8	9
67	R:R:N100	R:R:N179	19.0351	14.98	No	Yes	7	9	7
68	R:R:N100	R:R:T148	17.3633	4.39	No	No	0	9	7
69	R:R:N179	R:R:W183	17.3269	9.04	Yes	Yes	7	7	9
70	R:R:L101	R:R:T148	15.5006	7.37	No	No	0	9	7
71	R:R:L101	R:R:L149	12.3387	4.15	No	No	0	9	8
72	R:R:L149	R:R:V279	11.6754	1.49	No	Yes	0	8	8
73	R:R:T111	R:R:Y320	19.9618	4.99	Yes	Yes	1	7	6
74	R:R:F114	R:R:T111	11.2393	2.59	Yes	Yes	1	5	7
75	L:L:?1	R:R:V118	33.936	4.83	Yes	No	1	0	5
76	R:R:V118	R:R:W124	35.4625	3.68	No	Yes	1	5	8
77	R:R:F126	R:R:W124	11.312	8.02	Yes	Yes	1	7	8
78	R:R:L309	R:R:Y313	47.247	7.03	No	No	0	4	4
79	R:R:H304	R:R:L309	43.6943	1.29	No	No	0	1	4
80	R:R:D204	R:R:H304	36.5346	7.56	No	No	0	2	1
81	R:R:D204	R:R:R202	18.499	7.15	No	No	0	2	2
82	R:R:R202	R:R:V207	11.1576	3.92	No	No	0	2	3
83	R:R:S123	R:R:V207	14.8555	4.85	No	No	0	4	3
84	R:R:D204	R:R:V205	14.801	8.76	No	No	0	2	1
85	R:R:V205	R:R:V207	11.1303	6.41	No	No	0	1	3
86	R:R:A193	R:R:Y139	75.5588	2.67	No	Yes	0	5	5
87	R:R:A193	R:R:S136	73.7507	1.71	No	No	0	5	5
88	R:R:I194	R:R:S136	69.6257	3.1	Yes	No	0	4	5
89	R:R:I194	R:R:K132	63.3018	4.36	Yes	No	0	4	6
90	R:R:F235	R:R:F283	15.7278	5.36	Yes	Yes	1	8	9
91	R:R:F283	R:R:I146	20.4161	2.51	Yes	No	0	9	7
92	R:R:I146	R:R:P238	19.8528	3.39	No	No	0	7	9
93	R:R:P238	R:R:T150	16.7999	3.5	No	No	0	9	7
94	R:R:I242	R:R:Y246	10.4398	2.42	No	Yes	8	8	8
95	R:R:I242	R:R:T150	15.8368	6.08	No	No	0	8	7
96	R:R:A175	R:R:A93	14.7192	1.79	No	No	0	7	6
97	R:R:A93	R:R:D155	11.7391	1.54	No	No	0	6	8
98	R:R:M249	R:R:Y246	28.8479	2.39	No	Yes	0	8	8
99	R:R:M249	R:R:V160	15.1463	10.65	No	No	0	8	8
100	R:R:L253	R:R:V160	10.1581	2.98	No	No	0	8	8
101	R:R:G197	R:R:K132	30.5833	1.74	No	No	0	4	6
102	R:R:G197	R:R:Q213	28.3027	3.29	No	No	0	4	4
103	R:R:P215	R:R:Q213	51.899	3.16	No	No	0	5	4
104	R:R:P215	R:R:Y219	42.4314	2.78	No	Yes	0	5	1
105	R:R:F214	R:R:Y219	28.6026	2.06	Yes	Yes	2	6	1
106	R:R:F214	R:R:L212	14.1196	15.83	Yes	Yes	2	6	4
107	R:R:G198	R:R:K132	30.5833	1.74	No	No	0	4	6
108	R:R:G198	R:R:Q213	28.3027	4.93	No	No	0	4	4
109	R:R:I237	R:R:P238	12.4841	3.39	No	No	0	5	9
110	R:R:F233	R:R:I237	10.0218	2.51	No	No	0	4	5
111	R:R:F235	R:R:W287	20.6796	3.01	Yes	No	1	8	8
112	R:R:F235	R:R:T288	12.2933	7.78	Yes	Yes	0	8	5
113	R:R:I250	R:R:M249	11.8663	2.92	No	No	0	5	8
114	R:R:N322	R:R:W287	26.1585	11.3	Yes	No	0	9	8
115	R:R:N322	R:R:S323	26.749	4.47	Yes	No	0	9	8
116	L:L:?1	R:R:Y312	25.2226	3.04	Yes	No	1	0	4
117	R:R:F293	R:R:Y312	28.4481	8.25	Yes	No	0	5	4
118	R:R:E297	R:R:F293	10.9213	16.32	No	Yes	0	5	5
119	R:R:G319	R:R:N322	11.7936	5.09	No	Yes	0	7	9
120	R:R:I316	R:R:Q115	10.258	5.49	Yes	Yes	1	5	7
121	R:R:I316	R:R:Y320	13.2564	2.42	Yes	Yes	1	5	6
122	R:R:F99	R:R:M90	13.9924	7.46	Yes	No	6	5	7
123	R:R:M152	R:R:Y97	24.5048	3.59	Yes	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q115	6.05	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V118	4.83	1	Yes	No	0	5	0	1
L:L:?1	R:R:I135	4.63	1	Yes	No	0	4	0	1
L:L:?1	R:R:D138	23.78	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y139	6.85	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M142	8.26	1	Yes	No	0	7	0	1
L:L:?1	R:R:K227	6.41	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:I290	2.78	1	Yes	No	0	6	0	1
L:L:?1	R:R:H291	4.17	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I294	4.63	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y312	3.04	1	Yes	No	0	4	0	1
L:L:?1	R:R:I316	7.41	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y320	12.17	1	Yes	Yes	0	6	0	1
R:R:M112	R:R:Y66	14.37	1	Yes	Yes	7	6	2	2
R:R:Q115	R:R:Y66	4.51	1	Yes	Yes	7	6	1	2
R:R:Y320	R:R:Y66	6.95	1	Yes	Yes	6	6	1	2
R:R:V108	R:R:Y320	3.79	0	No	Yes	7	6	2	1
R:R:T111	R:R:Y320	4.99	1	Yes	Yes	7	6	2	1
R:R:M112	R:R:Y320	11.97	1	Yes	Yes	7	6	2	1
R:R:Q115	R:R:V118	4.3	1	Yes	No	7	5	1	1
R:R:I316	R:R:Q115	5.49	1	Yes	Yes	5	7	1	1
R:R:V118	R:R:W124	3.68	1	No	Yes	5	8	1	2
R:R:D138	R:R:Y139	6.9	1	No	Yes	6	5	1	1
R:R:M142	R:R:Y139	3.59	1	No	Yes	7	5	1	1
R:R:V189	R:R:Y139	2.52	0	Yes	Yes	5	5	2	1
R:R:A193	R:R:Y139	2.67	0	No	Yes	5	5	2	1
R:R:K227	R:R:V230	3.04	1	Yes	No	4	5	1	2
R:R:I294	R:R:K227	7.27	1	No	Yes	5	4	1	1
R:R:F231	R:R:H291	9.05	0	No	Yes	5	8	2	1
R:R:A234	R:R:H291	4.39	0	No	Yes	6	8	2	1
R:R:F235	R:R:H291	19.23	1	Yes	Yes	8	8	2	1
R:R:H291	R:R:I290	2.65	1	Yes	No	8	6	1	1
R:R:F293	R:R:Y312	8.25	0	Yes	No	5	4	2	1
R:R:I316	R:R:Y312	10.88	1	Yes	No	5	4	1	1
R:R:I316	R:R:Y320	2.42	1	Yes	Yes	5	6	1	1
R:R:Q115	R:R:Y313	2.25	1	Yes	No	7	4	1	2
R:R:A298	R:R:K227	1.61	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8VVF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.42
Number of Linked Nodes	252
Number of Links	286
Number of Hubs	42
Number of Links mediated by Hubs	161
Number of Communities	9
Number of Nodes involved in Communities	60
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	124
Number Of Links MetaPath	123
Number of Shortest Paths	42420
Length Of Smallest Path	3
Average Path Length	12.4327
Length of Longest Path	29
Minimum Path Strength	1.14
Average Path Strength	5.06478
Maximum Path Strength	17.975
Minimum Path Correlation	0.7
Average Path Correlation	0.923764
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	47.1992
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.1353
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to virus • defense response to other organism • response to stress • response to external biotic stimulus • response to virus • response to acrylamide • response to chemical • response to oxygen-containing compound • response to nitrogen compound • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to hormone • response to endogenous stimulus • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • response to lipid • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • inorganic ion transmembrane transport • regulation of potassium ion transmembrane transport • inorganic cation transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • intracellular anatomical structure • cytoplasm • cytosol • presynapse • presynaptic membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • intracellular organelle • organelle • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • vesicle • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • organelle membrane • exocytic vesicle • mitochondrion • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • axon • axon terminus • distal axon • neuron projection terminus • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	JDC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	JDC
Name	(3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Synonyms
Identifier
Formula	C28 H39 N3 O3
Molecular Weight	465.628
SMILES
PubChem	9956146
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	4
Total Bonds	76
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>8VVF_nogp_Chain_R A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	10.1101/2025.01.09.632033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	10.1101/2025.01.09.632033
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	10.1038/s41467-023-43718-w
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	10.1093/procel/pwac033
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	10.1038/s41586-023-06030-7
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	10.1038/s41467-023-37041-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	10.1016/j.cell.2022.12.026
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	10.1038/s41467-020-14889-7
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	10.1016/j.cell.2017.12.011
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	10.1038/nature10939
	4DJH (Multimeric)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		2.9	2012-03-21	10.1038/nature10939

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