psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I58	R:R:P56	3.39	No	No	0	4	2
2	R:R:I58	R:R:P59	3.39	No	No	0	4	4
3	R:R:Y313	R:R:Y66	8.94	Yes	Yes	0	4	6
4	R:R:I316	R:R:Y66	7.25	Yes	Yes	0	5	6
5	R:R:A317	R:R:Y66	5.34	No	Yes	0	5	6
6	R:R:T321	R:R:V69	3.17	No	No	0	5	7
7	R:R:F70	R:R:L74	9.74	No	No	0	7	6
8	R:R:F70	R:R:M112	7.46	No	No	0	7	7
9	R:R:F70	R:R:P113	5.78	No	No	0	7	8
10	R:R:S324	R:R:V72	3.23	No	No	0	7	5
11	R:R:G73	R:R:S324	3.71	No	No	0	8	7
12	R:R:L74	R:R:T109	4.42	No	No	0	6	6
13	R:R:G76	R:R:V75	3.68	No	No	0	7	4
14	R:R:D105	R:R:N77	4.04	Yes	No	0	9	9
15	R:R:A106	R:R:N77	4.69	No	No	0	8	9
16	R:R:N77	R:R:P327	6.52	No	No	0	9	9
17	R:R:F332	R:R:L79	6.09	Yes	No	0	6	6
18	R:R:A102	R:R:V80	3.39	No	Yes	0	8	9
19	R:R:A331	R:R:V80	3.39	No	Yes	0	7	9
20	R:R:F332	R:R:V80	3.93	Yes	Yes	0	6	9
21	R:R:F82	R:R:R86	8.55	No	Yes	0	4	5
22	R:R:F337	R:R:V83	9.18	No	No	0	8	8
23	R:R:F99	R:R:I84	3.77	No	No	0	5	7
24	R:R:N95	R:R:T88	5.85	No	No	0	7	6
25	R:R:F99	R:R:M90	3.73	No	No	0	5	7
26	R:R:N95	R:R:T92	4.39	No	No	0	7	7
27	R:R:I96	R:R:K176	5.82	No	No	0	5	4
28	R:R:M151	R:R:Y97	5.99	No	Yes	0	6	7
29	R:R:M152	R:R:Y97	4.79	No	Yes	0	8	7
30	R:R:D155	R:R:Y97	3.45	No	Yes	0	8	7
31	R:R:A175	R:R:Y97	4	No	Yes	0	7	7
32	R:R:N179	R:R:Y97	3.49	No	Yes	0	7	7
33	R:R:N100	R:R:T148	11.7	No	No	0	9	7
34	R:R:N100	R:R:N179	13.62	No	No	0	9	7
35	R:R:N100	R:R:W183	10.17	No	Yes	0	9	9
36	R:R:D105	R:R:L101	9.5	Yes	Yes	1	9	9
37	R:R:L101	R:R:T148	7.37	Yes	No	0	9	7
38	R:R:L101	R:R:L149	4.15	Yes	Yes	1	9	8
39	R:R:L101	R:R:M152	5.65	Yes	No	0	9	8
40	R:R:L101	R:R:N326	4.12	Yes	Yes	1	9	9
41	R:R:A104	R:R:T144	3.36	No	No	0	8	7
42	R:R:A104	R:R:S145	3.42	No	No	0	8	9
43	R:R:D105	R:R:S145	4.42	Yes	No	0	9	9
44	R:R:D105	R:R:S323	8.83	Yes	No	0	9	8
45	R:R:D105	R:R:N326	12.12	Yes	Yes	1	9	9
46	R:R:L107	R:R:N141	13.73	No	No	0	6	8
47	R:R:S323	R:R:V108	4.85	No	No	0	8	7
48	R:R:M112	R:R:T109	4.52	No	No	0	7	6
49	R:R:M112	R:R:Y320	15.57	No	Yes	0	7	6
50	R:R:F114	R:R:F126	21.43	No	Yes	0	5	7
51	R:R:F114	R:R:L130	4.87	No	No	0	5	5
52	R:R:F114	R:R:V134	5.24	No	No	0	5	6
53	R:R:Q115	R:R:Y313	5.64	No	Yes	0	7	4
54	R:R:Q115	R:R:Y320	3.38	No	Yes	1	7	6
55	L:L:?1	R:R:Q115	9.31	Yes	No	1	0	7
56	R:R:F126	R:R:T117	6.49	Yes	No	0	7	4
57	R:R:V118	R:R:W124	3.68	No	Yes	0	5	8
58	R:R:V118	R:R:Y313	3.79	No	Yes	0	5	4
59	R:R:S310	R:R:Y119	5.09	No	No	0	2	4
60	R:R:Y119	R:R:Y313	11.91	No	Yes	0	4	4
61	R:R:M121	R:R:P125	8.39	No	No	0	4	1
62	R:R:F126	R:R:W124	14.03	Yes	Yes	0	7	8
63	R:R:C131	R:R:W124	7.84	No	Yes	2	9	8
64	R:R:C210	R:R:W124	13.06	No	Yes	2	9	8
65	R:R:F126	R:R:P125	5.78	Yes	No	0	7	1
66	R:R:D128	R:R:T199	11.56	No	No	0	2	4
67	R:R:C131	R:R:T199	3.38	No	No	0	9	4
68	R:R:C131	R:R:C210	5.46	No	No	2	9	9
69	R:R:I133	R:R:I137	4.42	No	No	0	5	5
70	L:L:?1	R:R:V134	4.63	Yes	No	0	0	6
71	R:R:L135	R:R:Y139	4.69	Yes	Yes	1	4	5
72	R:R:L135	R:R:L212	5.54	Yes	Yes	1	4	4
73	L:L:?1	R:R:L135	10.76	Yes	Yes	1	0	4
74	R:R:I194	R:R:S136	7.74	No	No	0	4	5
75	R:R:D138	R:R:Y320	5.75	No	Yes	1	6	6
76	L:L:?1	R:R:D138	13.72	Yes	No	1	0	6
77	R:R:L212	R:R:Y139	3.52	Yes	Yes	1	4	5
78	R:R:M226	R:R:Y139	3.59	No	Yes	1	5	5
79	L:L:?1	R:R:Y139	4.56	Yes	Yes	1	0	5
80	R:R:N141	R:R:Y140	8.14	No	Yes	0	8	5
81	R:R:W183	R:R:Y140	8.68	Yes	Yes	0	9	5
82	R:R:S186	R:R:Y140	6.36	No	Yes	0	8	5
83	R:R:M142	R:R:W287	6.98	No	Yes	0	7	8
84	L:L:?1	R:R:M142	10.99	Yes	No	0	0	7
85	R:R:F143	R:R:F147	8.57	Yes	No	0	6	6
86	R:R:F143	R:R:V189	7.87	Yes	No	0	6	5
87	R:R:F143	R:R:V230	6.55	Yes	No	0	6	5
88	R:R:T144	R:R:W183	10.92	No	Yes	0	7	9
89	R:R:S186	R:R:T144	6.4	No	No	0	8	7
90	R:R:I146	R:R:P238	3.39	No	No	0	7	9
91	R:R:I146	R:R:W287	7.05	No	Yes	0	7	8
92	R:R:F147	R:R:L185	4.87	No	No	0	6	4
93	R:R:F283	R:R:L149	3.65	No	Yes	1	9	8
94	R:R:L149	R:R:N326	6.87	Yes	Yes	1	8	9
95	R:R:L149	R:R:Y330	4.69	Yes	Yes	1	8	9
96	R:R:P238	R:R:T150	3.5	No	No	0	9	7
97	R:R:I241	R:R:T150	4.56	No	No	0	6	7
98	R:R:I182	R:R:M151	4.37	No	No	0	7	6
99	R:R:M152	R:R:Y330	5.99	No	Yes	0	8	9
100	R:R:C245	R:R:S153	5.16	No	No	0	7	9
101	R:R:S153	R:R:Y246	10.17	No	Yes	0	9	8
102	R:R:D155	R:R:R170	15.48	No	No	0	8	6
103	R:R:R156	R:R:Y246	9.26	No	Yes	1	9	8
104	R:R:M249	R:R:R156	3.72	No	No	0	8	9
105	R:R:R156	R:R:Y330	10.29	No	Yes	1	9	9
106	R:R:I158	R:R:Y157	3.63	No	Yes	0	5	7
107	R:R:C161	R:R:Y157	6.72	No	Yes	3	7	7
108	R:R:H162	R:R:Y157	10.89	Yes	Yes	3	6	7
109	R:R:C245	R:R:Y157	8.06	No	Yes	0	7	7
110	R:R:L248	R:R:Y157	7.03	No	Yes	0	4	7
111	R:R:A159	R:R:R170	6.91	No	No	0	8	6
112	R:R:M249	R:R:V160	7.61	No	No	0	8	8
113	R:R:C161	R:R:H162	4.42	No	Yes	3	7	6
114	R:R:K174	R:R:T171	4.5	No	No	0	5	7
115	R:R:L196	R:R:L212	5.54	No	Yes	0	4	4
116	R:R:G198	R:R:Q213	4.93	No	No	0	4	4
117	R:R:I208	R:R:T199	4.56	No	No	0	4	4
118	R:R:K200	R:R:R202	11.14	No	No	0	2	2
119	R:R:K200	R:R:Q213	8.14	No	No	0	2	4
120	R:R:E209	R:R:R202	16.28	No	No	0	3	2
121	R:R:D206	R:R:V205	5.84	No	No	0	3	1
122	R:R:V205	R:R:V207	4.81	No	No	0	1	3
123	R:R:E209	R:R:S211	4.31	No	No	0	3	4
124	R:R:L212	R:R:M226	8.48	Yes	No	1	4	5
125	R:R:F214	R:R:W222	10.02	No	No	0	6	7
126	R:R:S220	R:R:W222	6.18	No	No	0	2	7
127	R:R:L224	R:R:W221	3.42	No	No	0	3	1
128	R:R:C229	R:R:F225	6.98	No	No	0	3	4
129	R:R:I294	R:R:K227	4.36	No	No	0	5	4
130	R:R:A298	R:R:K227	4.82	No	No	0	4	4
131	L:L:?1	R:R:V230	3.48	Yes	No	0	0	5
132	R:R:F231	R:R:F235	4.29	Yes	Yes	1	5	8
133	R:R:F231	R:R:V236	3.93	Yes	No	0	5	4
134	R:R:F231	R:R:H291	10.18	Yes	Yes	1	5	8
135	R:R:F231	R:R:L295	3.65	Yes	No	0	5	5
136	R:R:F235	R:R:V239	6.55	Yes	No	0	8	6
137	R:R:F235	R:R:T288	3.89	Yes	Yes	0	8	5
138	R:R:F235	R:R:H291	5.66	Yes	Yes	1	8	8
139	R:R:I237	R:R:P238	3.39	No	No	0	5	9
140	R:R:I242	R:R:Y246	3.63	No	Yes	0	8	8
141	R:R:I242	R:R:V280	4.61	No	No	0	8	8
142	R:R:V276	R:R:Y246	5.05	No	Yes	0	8	8
143	R:R:Y246	R:R:Y330	4.96	Yes	Yes	1	8	9
144	R:R:I250	R:R:T273	7.6	No	No	0	5	6
145	R:R:R252	R:R:V256	3.92	No	No	0	5	6
146	R:R:L253	R:R:V256	4.47	No	No	0	8	6
147	R:R:L253	R:R:L259	5.54	No	No	0	8	3
148	R:R:L258	R:R:L259	4.15	No	No	0	5	3
149	R:R:L259	R:R:L269	6.92	No	No	0	3	6
150	R:R:D266	R:R:G261	5.03	No	No	0	3	3
151	R:R:K265	R:R:S262	7.65	No	No	0	4	1
152	R:R:E264	R:R:R263	19.77	No	No	0	3	3
153	R:R:E264	R:R:R267	3.49	No	No	0	3	4
154	R:R:N268	R:R:R267	8.44	No	No	0	5	4
155	R:R:L275	R:R:L333	6.92	No	No	0	8	7
156	R:R:L329	R:R:V279	4.47	Yes	No	0	8	8
157	R:R:V279	R:R:Y330	6.31	No	Yes	0	8	9
158	R:R:L325	R:R:V282	4.47	No	No	0	6	7
159	R:R:L329	R:R:V282	4.47	Yes	No	0	8	7
160	R:R:F283	R:R:W287	12.03	No	Yes	1	9	8
161	R:R:F283	R:R:N322	4.83	No	Yes	1	9	9
162	R:R:T288	R:R:V284	3.17	Yes	No	0	5	6
163	R:R:C286	R:R:T321	3.38	No	No	0	8	5
164	R:R:C286	R:R:N322	7.87	No	Yes	0	8	9
165	R:R:H291	R:R:W287	3.17	Yes	Yes	1	8	8
166	R:R:N322	R:R:W287	9.04	Yes	Yes	1	9	8
167	R:R:P289	R:R:T288	3.5	No	Yes	0	9	5
168	R:R:C315	R:R:P289	3.77	No	No	0	7	9
169	R:R:L318	R:R:P289	3.28	No	No	0	8	9
170	R:R:H291	R:R:I290	3.98	Yes	Yes	1	8	6
171	R:R:C315	R:R:I290	3.27	No	Yes	0	7	6
172	R:R:I290	R:R:I316	4.42	Yes	Yes	1	6	5
173	L:L:?1	R:R:I290	4.44	Yes	Yes	1	0	6
174	R:R:E297	R:R:F293	10.49	No	No	1	5	5
175	R:R:F293	R:R:Y312	8.25	No	Yes	1	5	4
176	L:L:?1	R:R:I294	11.1	Yes	No	0	0	5
177	R:R:E297	R:R:Y312	6.73	No	Yes	1	5	4
178	R:R:Y312	R:R:Y313	5.96	Yes	Yes	0	4	4
179	R:R:I316	R:R:Y312	4.84	Yes	Yes	1	5	4
180	L:L:?1	R:R:Y312	10.94	Yes	Yes	1	0	4
181	R:R:I316	R:R:Y320	3.63	Yes	Yes	1	5	6
182	L:L:?1	R:R:I316	6.66	Yes	Yes	1	0	5
183	L:L:?1	R:R:Y320	9.12	Yes	Yes	1	0	6
184	R:R:N322	R:R:N326	5.45	Yes	Yes	1	9	9
185	R:R:F332	R:R:I328	3.77	Yes	No	0	6	7
186	R:R:F332	R:R:F337	5.36	Yes	No	0	6	8
187	R:R:E335	R:R:N336	5.26	No	No	0	4	6
188	R:R:T92	R:R:T94	3.14	No	No	0	7	8
189	R:R:I208	R:R:S123	3.1	No	No	0	4	4
190	R:R:R86	R:R:Y87	3.09	Yes	No	0	5	5
191	R:R:I232	R:R:V236	3.07	No	No	0	5	4
192	R:R:I243	R:R:V280	3.07	No	No	0	5	8
193	R:R:I98	R:R:T94	3.04	No	No	0	8	8
194	R:R:K91	R:R:T92	3	No	No	0	7	7
195	R:R:L329	R:R:V278	2.98	Yes	No	0	8	5
196	R:R:L120	R:R:T63	2.95	No	No	0	4	5
197	R:R:L251	R:R:T247	2.95	No	No	0	4	4
198	R:R:L269	R:R:T273	2.95	No	No	0	6	6
199	R:R:I58	R:R:I62	2.94	No	No	0	4	5
200	R:R:I178	R:R:I182	2.94	No	No	0	6	7
201	R:R:I194	R:R:K132	2.91	No	No	0	4	6
202	R:R:L103	R:R:M81	2.83	No	No	0	6	7
203	R:R:I96	R:R:N179	2.83	No	No	0	5	7
204	R:R:I137	R:R:N141	2.83	No	No	0	5	8
205	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
206	R:R:G319	R:R:W287	2.81	No	Yes	0	7	8
207	R:R:C161	R:R:R252	2.79	No	No	0	7	5
208	R:R:A234	R:R:F143	2.77	No	Yes	0	6	6
209	R:R:A166	R:R:R170	2.77	No	No	0	5	6
210	R:R:R252	R:R:S255	2.64	No	No	0	5	4
211	R:R:R257	R:R:S260	2.64	No	No	0	4	4
212	R:R:F293	R:R:V296	2.62	No	No	0	5	4
213	R:R:S187	R:R:Y140	2.54	No	Yes	0	4	5
214	R:R:I85	R:R:R86	2.51	No	Yes	0	3	5
215	R:R:F233	R:R:I232	2.51	No	No	0	4	5
216	R:R:F233	R:R:I237	2.51	No	No	0	4	5
217	R:R:T111	R:R:Y320	2.5	No	Yes	0	7	6
218	R:R:F169	R:R:K174	2.48	No	No	0	4	5
219	R:R:K338	R:R:R339	2.48	No	No	0	8	5
220	R:R:I62	R:R:Y66	2.42	No	Yes	0	5	6
221	R:R:L103	R:R:W183	2.28	No	Yes	0	6	9
222	R:R:G197	R:R:G198	2.11	No	No	0	4	4
223	R:R:G190	R:R:S136	1.86	No	No	0	6	5
224	R:R:G261	R:R:S260	1.86	No	No	0	3	4
225	R:R:G261	R:R:S262	1.86	No	No	0	3	1
226	R:R:G73	R:R:T109	1.82	No	No	0	8	6
227	R:R:A175	R:R:A93	1.79	No	No	0	7	6
228	R:R:P327	R:R:V80	1.77	No	Yes	0	9	9
229	R:R:P172	R:R:T171	1.75	No	No	0	2	7
230	R:R:G197	R:R:L135	1.71	No	Yes	1	4	4
231	R:R:C245	R:R:V154	1.71	No	No	0	7	6
232	R:R:G197	R:R:L212	1.71	No	Yes	1	4	4
233	R:R:A57	R:R:V60	1.7	No	No	0	4	5
234	R:R:A317	R:R:V65	1.7	No	No	0	5	5
235	R:R:A307	R:R:T306	1.68	No	No	0	4	2
236	R:R:A308	R:R:T306	1.68	No	No	0	3	2
237	R:R:C181	R:R:I177	1.64	No	No	0	4	3
238	R:R:A57	R:R:I61	1.62	No	No	0	4	5
239	R:R:S67	R:R:V71	1.62	No	No	0	4	5
240	R:R:S123	R:R:V207	1.62	No	No	0	4	3
241	R:R:S116	R:R:T63	1.6	No	No	0	6	5
242	R:R:V68	R:R:V72	1.6	No	No	0	5	5
243	R:R:V71	R:R:V75	1.6	No	No	0	5	4
244	R:R:A193	R:R:L135	1.58	No	Yes	1	5	4
245	R:R:A193	R:R:L212	1.58	No	Yes	1	5	4
246	R:R:A298	R:R:L224	1.58	No	No	0	4	3
247	R:R:A298	R:R:L299	1.58	No	No	0	4	4
248	R:R:I191	R:R:S187	1.55	No	No	0	4	4
249	R:R:I84	R:R:V80	1.54	No	Yes	0	7	9
250	R:R:I98	R:R:V80	1.54	No	Yes	0	8	9
251	R:R:I208	R:R:V201	1.54	No	No	0	4	2
252	R:R:I272	R:R:V276	1.54	No	No	0	7	8
253	R:R:H162	R:R:P163	1.53	Yes	No	0	6	8
254	R:R:I292	R:R:T288	1.52	No	Yes	0	5	5
255	R:R:F332	R:R:G76	1.51	Yes	No	0	6	7
256	R:R:L130	R:R:V129	1.49	No	No	0	5	1
257	R:R:L196	R:R:V195	1.49	No	No	0	4	4
258	R:R:L240	R:R:V236	1.49	No	No	0	3	4
259	R:R:L248	R:R:V244	1.49	No	No	0	4	4
260	R:R:I84	R:R:I85	1.47	No	No	0	7	3
261	R:R:L173	R:R:T171	1.47	No	No	0	4	7
262	R:R:I191	R:R:I194	1.47	No	No	0	4	4
263	R:R:I228	R:R:I232	1.47	No	No	0	5	5
264	R:R:L248	R:R:T247	1.47	No	No	0	4	4
265	R:R:L277	R:R:T273	1.47	No	No	0	4	6
266	R:R:L120	R:R:M121	1.41	No	No	0	4	4
267	R:R:K254	R:R:L251	1.41	No	No	0	4	4
268	R:R:K254	R:R:L269	1.41	No	No	0	4	6
269	R:R:D334	R:R:I98	1.4	No	No	0	8	8
270	R:R:C229	R:R:F233	1.4	No	No	0	3	4
271	R:R:A317	R:R:F314	1.39	No	No	0	5	5
272	R:R:L329	R:R:L333	1.38	Yes	No	0	8	7
273	R:R:D168	R:R:L167	1.36	No	No	0	4	5
274	R:R:E264	R:R:K265	1.35	No	No	0	3	4
275	R:R:H162	R:R:K165	1.31	Yes	No	0	6	4
276	R:R:K89	R:R:R86	1.24	No	Yes	0	5	5
277	R:R:F337	R:R:K338	1.24	No	No	0	8	8
278	R:R:F214	R:R:L196	1.22	No	No	0	6	4
279	R:R:D168	R:R:F169	1.19	No	No	0	4	4
280	R:R:I180	R:R:W183	1.17	No	Yes	0	4	9
281	R:R:R271	R:R:R274	1.07	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y66	5.9875	4	0	6
2	R:R:V80	2.59333	6	0	9
3	R:R:R86	3.8475	4	0	5
4	R:R:Y97	4.344	5	0	7
5	R:R:L101	6.158	5	1	9
6	R:R:D105	7.782	5	1	9
7	R:R:W124	8.284	5	2	8
8	R:R:F126	11.9325	4	0	7
9	R:R:L135	4.856	5	1	4
10	R:R:Y139	4.09	4	1	5
11	R:R:Y140	6.43	4	0	5
12	R:R:F143	6.44	4	0	6
13	R:R:L149	4.84	4	1	8
14	R:R:Y157	7.266	5	3	7
15	R:R:H162	4.5375	4	3	6
16	R:R:W183	6.644	5	0	9
17	R:R:L212	4.395	6	1	4
18	R:R:F231	5.5125	4	1	5
19	R:R:F235	5.0975	4	1	8
20	R:R:Y246	6.614	5	1	8
21	R:R:W287	6.84667	6	1	8
22	R:R:T288	3.02	4	0	5
23	R:R:I290	4.0275	4	1	6
24	R:R:H291	5.7475	4	1	8
25	R:R:Y312	7.344	5	1	4
26	R:R:Y313	7.248	5	0	4
27	R:R:I316	5.36	5	1	5
28	R:R:Y320	6.65833	6	1	6
29	R:R:N322	6.7975	4	1	9
30	R:R:N326	7.14	4	1	9
31	R:R:L329	3.325	4	0	8
32	R:R:Y330	6.448	5	1	9
33	R:R:F332	4.132	5	0	6
34	L:L:?1	8.30917	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I316	R:R:Y66	18.0257	7.25	Yes	Yes	0	5	6
2	R:R:I290	R:R:I316	13.3863	4.42	Yes	Yes	1	6	5
3	R:R:H291	R:R:I290	22.6886	3.98	Yes	Yes	1	8	6
4	R:R:H291	R:R:W287	22.5239	3.17	Yes	Yes	1	8	8
5	R:R:N322	R:R:W287	57.8507	9.04	Yes	Yes	1	9	8
6	L:L:?1	R:R:M142	99.5342	10.99	Yes	No	0	0	7
7	R:R:M142	R:R:W287	100	6.98	No	Yes	0	7	8
8	R:R:M112	R:R:Y320	14.5815	15.57	No	Yes	0	7	6
9	R:R:F332	R:R:V80	19.5596	3.93	Yes	Yes	0	6	9
10	R:R:P327	R:R:V80	48.986	1.77	No	Yes	0	9	9
11	R:R:N77	R:R:P327	50.5387	6.52	No	No	0	9	9
12	R:R:D105	R:R:N77	53.616	4.04	Yes	No	0	9	9
13	R:R:D105	R:R:N326	37.4818	12.12	Yes	Yes	1	9	9
14	R:R:N322	R:R:N326	57.3049	5.45	Yes	Yes	1	9	9
15	R:R:I84	R:R:V80	14.3368	1.54	No	Yes	0	7	9
16	R:R:I98	R:R:V80	12.4453	1.54	No	Yes	0	8	9
17	R:R:F283	R:R:W287	66.3389	12.03	No	Yes	1	9	8
18	R:R:F283	R:R:L149	67.2093	3.65	No	Yes	1	9	8
19	R:R:L101	R:R:L149	37.9852	4.15	Yes	Yes	1	9	8
20	R:R:L101	R:R:T148	41.3306	7.37	Yes	No	0	9	7
21	R:R:N100	R:R:T148	39.3686	11.7	No	No	0	9	7
22	R:R:N100	R:R:N179	10.0739	13.62	No	No	0	9	7
23	R:R:L101	R:R:N326	26.5092	4.12	Yes	Yes	1	9	9
24	R:R:L101	R:R:M152	35.2233	5.65	Yes	No	0	9	8
25	R:R:M152	R:R:Y97	37.8158	4.79	No	Yes	0	8	7
26	R:R:N179	R:R:Y97	12.7276	3.49	No	Yes	0	7	7
27	R:R:L149	R:R:Y330	60.5044	4.69	Yes	Yes	1	8	9
28	R:R:M152	R:R:Y330	28.2784	5.99	No	Yes	0	8	9
29	R:R:D155	R:R:Y97	11.062	3.45	No	Yes	0	8	7
30	R:R:N100	R:R:W183	37.0395	10.17	No	Yes	0	9	9
31	R:R:D105	R:R:S145	10.5491	4.42	Yes	No	0	9	9
32	R:R:W183	R:R:Y140	28.4807	8.68	Yes	Yes	0	9	5
33	R:R:N141	R:R:Y140	10.9679	8.14	No	Yes	0	8	5
34	R:R:F114	R:R:V134	25.5493	5.24	No	No	0	5	6
35	L:L:?1	R:R:V134	26.6033	4.63	Yes	No	0	0	6
36	R:R:F126	R:R:W124	14.7085	14.03	Yes	Yes	0	7	8
37	R:R:V118	R:R:W124	31.6238	3.68	No	Yes	0	5	8
38	R:R:V118	R:R:Y313	33.9999	3.79	No	Yes	0	5	4
39	R:R:Q115	R:R:Y313	18.9667	5.64	No	Yes	0	7	4
40	R:R:C131	R:R:W124	34.1411	7.84	No	Yes	2	9	8
41	R:R:C131	R:R:T199	30.6357	3.38	No	No	0	9	4
42	L:L:?1	R:R:L135	20.6418	10.76	Yes	Yes	1	0	4
43	L:L:?1	R:R:Y139	10.6808	4.56	Yes	Yes	1	0	5
44	R:R:I191	R:R:I194	10.9679	1.47	No	No	0	4	4
45	R:R:I191	R:R:S187	13.6875	1.55	No	No	0	4	4
46	R:R:S187	R:R:Y140	16.3977	2.54	No	Yes	0	4	5
47	R:R:I146	R:R:W287	11.4007	7.05	No	Yes	0	7	8
48	R:R:C245	R:R:S153	40.352	5.16	No	No	0	7	9
49	R:R:S153	R:R:Y246	42.0129	10.17	No	Yes	0	9	8
50	R:R:Y246	R:R:Y330	50.934	4.96	Yes	Yes	1	8	9
51	R:R:C245	R:R:Y157	37.0018	8.06	No	Yes	0	7	7
52	R:R:C161	R:R:Y157	12.4782	6.72	No	Yes	3	7	7
53	R:R:L248	R:R:Y157	16.0495	7.03	No	Yes	0	4	7
54	R:R:L196	R:R:L212	14.0498	5.54	No	Yes	0	4	4
55	R:R:I208	R:R:T199	23.032	4.56	No	No	0	4	4
56	R:R:S123	R:R:V207	11.556	1.62	No	No	0	4	3
57	R:R:I208	R:R:S123	15.3908	3.1	No	No	0	4	4
58	R:R:F231	R:R:H291	12.1112	10.18	Yes	Yes	1	5	8
59	R:R:L251	R:R:T247	10.6808	2.95	No	No	0	4	4
60	R:R:L248	R:R:T247	12.4735	1.47	No	No	0	4	4
61	R:R:C161	R:R:R252	10.8455	2.79	No	No	0	7	5
62	R:R:V279	R:R:Y330	12.9394	6.31	No	Yes	0	8	9
63	R:R:L329	R:R:V279	11.1184	4.47	Yes	No	0	8	8
64	R:R:Y312	R:R:Y313	20.0019	5.96	Yes	Yes	0	4	4
65	L:L:?1	R:R:Q115	18.9291	9.31	Yes	No	1	0	7
66	L:L:?1	R:R:Y312	22.298	10.94	Yes	Yes	1	0	4
67	R:R:F114	R:R:F126	22.1522	21.43	No	Yes	0	5	7
68	L:L:?1	R:R:I290	11.2972	4.44	Yes	Yes	1	0	6
69	L:L:?1	R:R:Y320	14.3039	9.12	Yes	Yes	1	0	6
70	R:R:D105	R:R:L101	21.3476	9.5	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y313	R:R:Y66	8.94	0	Yes	Yes	4	6	2	2
R:R:I316	R:R:Y66	7.25	1	Yes	Yes	5	6	1	2
R:R:M112	R:R:Y320	15.57	0	No	Yes	7	6	2	1
R:R:F114	R:R:V134	5.24	0	No	No	5	6	2	1
R:R:Q115	R:R:Y313	5.64	1	No	Yes	7	4	1	2
R:R:Q115	R:R:Y320	3.38	1	No	Yes	7	6	1	1
L:L:?1	R:R:Q115	9.31	1	Yes	No	0	7	0	1
L:L:?1	R:R:V134	4.63	1	Yes	No	0	6	0	1
R:R:L135	R:R:Y139	4.69	1	Yes	Yes	4	5	1	1
R:R:L135	R:R:L212	5.54	1	Yes	Yes	4	4	1	2
L:L:?1	R:R:L135	10.76	1	Yes	Yes	0	4	0	1
R:R:D138	R:R:Y320	5.75	1	No	Yes	6	6	1	1
L:L:?1	R:R:D138	13.72	1	Yes	No	0	6	0	1
R:R:L212	R:R:Y139	3.52	1	Yes	Yes	4	5	2	1
R:R:M226	R:R:Y139	3.59	1	No	Yes	5	5	2	1
L:L:?1	R:R:Y139	4.56	1	Yes	Yes	0	5	0	1
R:R:M142	R:R:W287	6.98	0	No	Yes	7	8	1	2
L:L:?1	R:R:M142	10.99	1	Yes	No	0	7	0	1
R:R:F143	R:R:V230	6.55	0	Yes	No	6	5	2	1
R:R:L212	R:R:M226	8.48	1	Yes	No	4	5	2	2
R:R:I294	R:R:K227	4.36	0	No	No	5	4	1	2
L:L:?1	R:R:V230	3.48	1	Yes	No	0	5	0	1
R:R:H291	R:R:W287	3.17	1	Yes	Yes	8	8	2	2
R:R:H291	R:R:I290	3.98	1	Yes	Yes	8	6	2	1
R:R:C315	R:R:I290	3.27	0	No	Yes	7	6	2	1
R:R:I290	R:R:I316	4.42	1	Yes	Yes	6	5	1	1
L:L:?1	R:R:I290	4.44	1	Yes	Yes	0	6	0	1
R:R:E297	R:R:F293	10.49	1	No	No	5	5	2	2
R:R:F293	R:R:Y312	8.25	1	No	Yes	5	4	2	1
L:L:?1	R:R:I294	11.1	1	Yes	No	0	5	0	1
R:R:E297	R:R:Y312	6.73	1	No	Yes	5	4	2	1
R:R:Y312	R:R:Y313	5.96	1	Yes	Yes	4	4	1	2
R:R:I316	R:R:Y312	4.84	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:Y312	10.94	1	Yes	Yes	0	4	0	1
R:R:I316	R:R:Y320	3.63	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:I316	6.66	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y320	9.12	1	Yes	Yes	0	6	0	1
R:R:T111	R:R:Y320	2.5	0	No	Yes	7	6	2	1
R:R:G197	R:R:L135	1.71	1	No	Yes	4	4	2	1
R:R:G197	R:R:L212	1.71	1	No	Yes	4	4	2	2
R:R:A193	R:R:L135	1.58	1	No	Yes	5	4	2	1
R:R:A193	R:R:L212	1.58	1	No	Yes	5	4	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8DZQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	258
Number of Links	281
Number of Hubs	34
Number of Links mediated by Hubs	131
Number of Communities	3
Number of Nodes involved in Communities	34
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	49701
Length Of Smallest Path	3
Average Path Length	12.4644
Length of Longest Path	28
Minimum Path Strength	1.275
Average Path Strength	6.16503
Maximum Path Strength	17.73
Minimum Path Correlation	0.7
Average Path Correlation	0.920379
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.1795
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.6551
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • glutamatergic synapse • cell body • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • dynorphin receptor activity • receptor serine/threonine kinase binding • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • G protein-coupled opioid receptor signaling pathway • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to virus • defense response to other organism • response to stress • response to external biotic stimulus • response to virus • response to acrylamide • neuropeptide signaling pathway • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • response to hexose • cellular response to carbohydrate stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • negative regulation of luteinizing hormone secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • gonadotropin secretion • regulation of gonadotropin secretion • endocrine process • eating behavior • feeding behavior • sensory perception of temperature stimulus • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • response to molecule of bacterial origin • adenylate cyclase-inhibiting opioid receptor signaling pathway • monoamine transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • inorganic ion transmembrane transport • regulation of potassium ion transmembrane transport • inorganic cation transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • sarcolemma • T-tubule • perikaryon • neuronal cell body • endomembrane system • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • exocytic vesicle • mitochondrion • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • axon • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U99
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U99
Name	methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxododecahydro-2H-naphtho[2,1-c]pyran-7-carboxylate
Synonyms
Identifier
Formula	C23 H30 O8
Molecular Weight	434.48
SMILES
PubChem	44456192
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	7
Total Bonds	64
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>8DZQ_nogp_Chain_R P A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R V D V I E C S L Q F S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	10.1101/2025.01.09.632033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	10.1101/2025.01.09.632033
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	10.1038/s41467-023-43718-w
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	10.1093/procel/pwac033
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	10.1038/s41586-023-06030-7
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	10.1038/s41467-023-37041-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	10.1016/j.cell.2022.12.026
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	10.1038/s41467-020-14889-7
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	10.1016/j.cell.2017.12.011
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	10.1038/nature10939
	4DJH (Multimeric)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		2.9	2012-03-21	10.1038/nature10939

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