psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q115	2.36	Yes	Yes	1	0	7
2	L:L:?1	R:R:I135	5.06	Yes	No	1	0	4
3	L:L:?1	R:R:D138	4.81	Yes	No	0	0	6
4	L:L:?1	R:R:Y139	21.82	Yes	No	1	0	5
5	L:L:?1	R:R:M142	13.78	Yes	Yes	1	0	7
6	L:L:?1	R:R:F143	5.4	Yes	No	0	0	6
7	L:L:?1	R:R:W287	5.05	Yes	Yes	1	0	8
8	L:L:?1	R:R:I290	5.06	Yes	No	1	0	6
9	L:L:?1	R:R:H291	14.81	Yes	No	0	0	8
10	L:L:?1	R:R:I294	15.18	Yes	No	0	0	5
11	L:L:?1	R:R:Y312	3.12	Yes	No	0	0	4
12	L:L:?1	R:R:I316	3.79	Yes	No	1	0	5
13	R:R:A57	R:R:V60	3.39	No	No	0	4	5
14	R:R:I58	R:R:P59	3.39	No	No	0	4	4
15	R:R:I61	R:R:V60	6.14	No	No	0	5	5
16	R:R:I62	R:R:Y66	6.04	No	Yes	5	5	6
17	R:R:I62	R:R:Y119	8.46	No	Yes	5	5	4
18	R:R:S116	R:R:Y66	2.54	No	Yes	0	6	6
19	R:R:Y119	R:R:Y66	2.98	Yes	Yes	5	4	6
20	R:R:A317	R:R:Y66	4	No	Yes	0	5	6
21	R:R:M112	R:R:V69	3.04	No	No	0	7	7
22	R:R:T321	R:R:V69	3.17	No	No	0	5	7
23	R:R:F70	R:R:L74	12.18	No	No	0	7	6
24	R:R:F70	R:R:M112	8.71	No	No	0	7	7
25	R:R:F70	R:R:P113	11.56	No	No	0	7	8
26	R:R:G73	R:R:T109	3.64	No	No	0	8	6
27	R:R:G73	R:R:S324	3.71	No	No	0	8	7
28	R:R:G76	R:R:V75	3.68	No	No	0	7	4
29	R:R:D105	R:R:N77	12.12	No	No	1	9	9
30	R:R:N77	R:R:T109	4.39	No	No	0	9	6
31	R:R:N77	R:R:P327	6.52	No	No	1	9	9
32	R:R:F341	R:R:L79	4.87	No	No	0	6	6
33	R:R:I85	R:R:M81	2.92	No	No	0	3	7
34	R:R:F99	R:R:M81	4.98	No	No	0	5	7
35	R:R:A102	R:R:M81	3.22	No	No	0	8	7
36	R:R:F341	R:R:V83	10.49	No	No	0	6	8
37	R:R:I84	R:R:T88	6.08	No	No	0	7	6
38	R:R:F337	R:R:I84	5.02	Yes	No	0	8	7
39	R:R:R86	R:R:Y87	11.32	No	No	0	5	5
40	R:R:C340	R:R:Y87	4.03	No	No	0	6	5
41	R:R:N95	R:R:T88	5.85	No	No	0	7	6
42	R:R:C340	R:R:T88	3.38	No	No	0	6	6
43	R:R:K176	R:R:M90	2.88	No	No	0	4	7
44	R:R:T92	R:R:T94	4.71	No	No	0	7	8
45	R:R:N95	R:R:T92	13.16	No	No	0	7	7
46	R:R:A93	R:R:R170	4.15	No	Yes	0	6	6
47	R:R:M152	R:R:Y97	5.99	No	Yes	0	8	7
48	R:R:A175	R:R:Y97	4	No	Yes	0	7	7
49	R:R:I178	R:R:Y97	2.42	No	Yes	0	6	7
50	R:R:N179	R:R:Y97	2.33	No	Yes	0	7	7
51	R:R:F337	R:R:I98	3.77	Yes	No	0	8	8
52	R:R:F99	R:R:N100	4.83	No	No	0	5	9
53	R:R:F99	R:R:L103	3.65	No	No	0	5	6
54	R:R:N100	R:R:T148	2.92	No	No	0	9	7
55	R:R:N100	R:R:N179	6.81	No	No	0	9	7
56	R:R:L101	R:R:T148	5.9	No	No	0	9	7
57	R:R:L101	R:R:L149	2.77	No	Yes	0	9	8
58	R:R:L103	R:R:W183	2.28	No	No	0	6	9
59	R:R:D105	R:R:P327	9.66	No	No	1	9	9
60	R:R:L107	R:R:T110	2.95	No	No	0	6	4
61	R:R:I137	R:R:L107	7.14	No	No	0	5	6
62	R:R:L107	R:R:N141	8.24	No	Yes	0	6	8
63	R:R:N141	R:R:V108	4.43	Yes	No	0	8	7
64	R:R:V108	R:R:Y320	3.79	No	Yes	0	7	6
65	R:R:S323	R:R:V108	6.46	No	No	0	8	7
66	R:R:F114	R:R:T111	3.89	No	No	1	5	7
67	R:R:T111	R:R:V134	3.17	No	No	1	7	6
68	R:R:T111	R:R:Y320	6.24	No	Yes	1	7	6
69	R:R:M112	R:R:Y320	8.38	No	Yes	0	7	6
70	R:R:F114	R:R:F126	6.43	No	Yes	0	5	7
71	R:R:F114	R:R:V134	3.93	No	No	1	5	6
72	R:R:Q115	R:R:V118	2.87	Yes	No	0	7	5
73	R:R:I316	R:R:Q115	8.23	No	Yes	1	5	7
74	R:R:Q115	R:R:Y320	5.64	Yes	Yes	1	7	6
75	R:R:F126	R:R:T117	2.59	Yes	No	0	7	4
76	R:R:S310	R:R:Y119	2.54	No	Yes	0	2	4
77	R:R:Y119	R:R:Y313	18.86	Yes	No	0	4	4
78	R:R:M121	R:R:P125	6.71	No	No	0	4	1
79	R:R:F126	R:R:W124	5.01	Yes	Yes	0	7	8
80	R:R:C131	R:R:W124	7.84	No	Yes	6	9	8
81	R:R:T199	R:R:W124	4.85	No	Yes	0	4	8
82	R:R:I208	R:R:W124	12.92	No	Yes	0	4	8
83	R:R:C210	R:R:W124	10.45	No	Yes	6	9	8
84	R:R:F126	R:R:P125	2.89	Yes	No	0	7	1
85	R:R:F126	R:R:L130	8.53	Yes	No	0	7	5
86	R:R:D128	R:R:V129	5.84	No	No	0	2	1
87	R:R:C131	R:R:C210	7.28	No	No	6	9	9
88	R:R:I135	R:R:Y139	2.42	No	No	1	4	5
89	R:R:A193	R:R:S136	3.42	No	No	0	5	5
90	R:R:I194	R:R:S136	6.19	No	No	0	4	5
91	R:R:D138	R:R:N141	4.04	No	Yes	0	6	8
92	R:R:D138	R:R:Y320	3.45	No	Yes	0	6	6
93	R:R:W183	R:R:Y140	10.61	No	Yes	0	9	5
94	R:R:S186	R:R:Y140	2.54	No	Yes	0	8	5
95	R:R:S187	R:R:Y140	6.36	No	Yes	0	4	5
96	R:R:G190	R:R:Y140	2.9	No	Yes	0	6	5
97	R:R:M142	R:R:N141	4.21	Yes	Yes	0	7	8
98	R:R:M142	R:R:S145	3.07	Yes	No	0	7	9
99	R:R:M142	R:R:W287	6.98	Yes	Yes	1	7	8
100	R:R:F143	R:R:V189	5.24	No	No	0	6	5
101	R:R:F143	R:R:V230	2.62	No	No	0	6	5
102	R:R:T144	R:R:W183	18.19	No	No	0	7	9
103	R:R:S186	R:R:T144	3.2	No	No	0	8	7
104	R:R:I146	R:R:S145	3.1	No	No	0	7	9
105	R:R:I146	R:R:P238	3.39	No	No	0	7	9
106	R:R:F283	R:R:I146	3.77	Yes	No	0	9	7
107	R:R:F147	R:R:S186	3.96	No	No	0	6	8
108	R:R:I182	R:R:T148	3.04	No	No	0	7	7
109	R:R:F283	R:R:L149	2.44	Yes	Yes	1	9	8
110	R:R:L149	R:R:N326	4.12	Yes	No	1	8	9
111	R:R:L149	R:R:Y330	3.52	Yes	Yes	1	8	9
112	R:R:P238	R:R:T150	5.25	No	No	0	9	7
113	R:R:I241	R:R:T150	4.56	No	No	0	6	7
114	R:R:I178	R:R:M151	4.37	No	No	0	6	6
115	R:R:M152	R:R:R156	2.48	No	No	0	8	9
116	R:R:M152	R:R:Y330	5.99	No	Yes	0	8	9
117	R:R:I242	R:R:S153	4.64	No	No	2	8	9
118	R:R:S153	R:R:Y246	6.36	No	Yes	2	9	8
119	R:R:D155	R:R:R170	15.48	No	Yes	0	8	6
120	R:R:R156	R:R:Y246	3.09	No	Yes	2	9	8
121	R:R:M249	R:R:R156	2.48	No	No	2	8	9
122	R:R:I158	R:R:Y157	3.63	No	Yes	0	5	7
123	R:R:C161	R:R:Y157	5.38	Yes	Yes	3	7	7
124	R:R:H162	R:R:Y157	10.89	Yes	Yes	3	6	7
125	R:R:C245	R:R:Y157	5.38	No	Yes	0	7	7
126	R:R:L248	R:R:Y157	2.34	No	Yes	3	4	7
127	R:R:F169	R:R:I158	5.02	No	No	0	4	5
128	R:R:A159	R:R:R170	4.15	No	Yes	0	8	6
129	R:R:M249	R:R:V160	7.61	No	No	0	8	8
130	R:R:C161	R:R:H162	2.95	Yes	Yes	3	7	6
131	R:R:C161	R:R:L248	3.17	Yes	No	3	7	4
132	R:R:C161	R:R:R252	6.96	Yes	No	0	7	5
133	R:R:K165	R:R:V164	9.11	No	No	0	4	5
134	R:R:F169	R:R:I178	3.77	No	No	0	4	6
135	R:R:K174	R:R:T171	3	No	No	0	5	7
136	R:R:I177	R:R:L173	2.85	No	No	0	3	4
137	R:R:I180	R:R:N179	4.25	No	No	0	4	7
138	R:R:S192	R:R:V189	3.23	No	No	0	7	5
139	R:R:L196	R:R:L212	2.77	No	No	0	4	4
140	R:R:K200	R:R:Q213	8.14	No	No	0	2	4
141	R:R:I208	R:R:V201	4.61	No	No	0	4	2
142	R:R:D204	R:R:R202	11.91	No	Yes	7	2	2
143	R:R:R202	R:R:V205	2.62	Yes	No	7	2	1
144	R:R:R202	R:R:V207	9.15	Yes	No	0	2	3
145	R:R:E209	R:R:R202	3.49	No	Yes	0	3	2
146	R:R:D204	R:R:V205	7.3	No	No	7	2	1
147	R:R:E209	R:R:S211	7.19	No	No	0	3	4
148	R:R:K227	R:R:L212	4.23	Yes	No	0	4	4
149	R:R:D217	R:R:F214	2.39	No	Yes	4	1	6
150	R:R:F214	R:R:Y219	4.13	Yes	No	4	6	1
151	R:R:F214	R:R:W222	5.01	Yes	No	4	6	7
152	R:R:D223	R:R:F214	2.39	No	Yes	0	4	6
153	R:R:D217	R:R:Y219	6.9	No	No	4	1	1
154	R:R:W222	R:R:Y219	10.61	No	No	4	7	1
155	R:R:S220	R:R:W221	6.18	No	No	0	2	1
156	R:R:D223	R:R:K227	4.15	No	Yes	0	4	4
157	R:R:F225	R:R:L224	2.44	No	No	8	4	3
158	R:R:I228	R:R:L224	2.85	No	No	8	5	3
159	R:R:F225	R:R:I228	3.77	No	No	8	4	5
160	R:R:A298	R:R:K227	4.82	No	Yes	0	4	4
161	R:R:F231	R:R:I232	2.51	No	Yes	9	5	5
162	R:R:F231	R:R:V236	3.93	No	No	9	5	4
163	R:R:F231	R:R:L295	6.09	No	No	0	5	5
164	R:R:F233	R:R:I232	3.77	No	Yes	0	4	5
165	R:R:I232	R:R:V236	6.14	Yes	No	9	5	4
166	R:R:A234	R:R:H291	4.39	No	No	0	6	8
167	R:R:F235	R:R:V239	6.55	Yes	No	1	8	6
168	R:R:F235	R:R:F283	6.43	Yes	Yes	1	8	9
169	R:R:F235	R:R:W287	3.01	Yes	Yes	1	8	8
170	R:R:F235	R:R:T288	5.19	Yes	Yes	0	8	5
171	R:R:F235	R:R:H291	15.84	Yes	No	0	8	8
172	R:R:I237	R:R:P238	3.39	No	No	0	5	9
173	R:R:F283	R:R:V239	3.93	Yes	No	1	9	6
174	R:R:L240	R:R:V244	2.98	No	No	0	3	4
175	R:R:I242	R:R:Y246	2.42	No	Yes	2	8	8
176	R:R:M249	R:R:Y246	3.59	No	Yes	2	8	8
177	R:R:V280	R:R:Y246	2.52	No	Yes	0	8	8
178	R:R:I250	R:R:T273	9.12	No	No	0	5	6
179	R:R:R252	R:R:V256	2.62	No	No	0	5	6
180	R:R:L253	R:R:L259	4.15	Yes	No	0	8	3
181	R:R:L253	R:R:L269	4.15	Yes	No	0	8	6
182	R:R:K254	R:R:L269	2.82	No	No	0	4	6
183	R:R:L258	R:R:L259	2.77	No	No	10	5	3
184	R:R:K265	R:R:L258	2.82	Yes	No	10	4	5
185	R:R:K265	R:R:L259	7.05	Yes	No	10	4	3
186	R:R:K265	R:R:S262	6.12	Yes	No	0	4	1
187	R:R:E264	R:R:R263	4.65	No	No	0	3	3
188	R:R:R263	R:R:R267	7.46	No	No	0	3	4
189	R:R:I272	R:R:N268	2.83	No	No	0	7	5
190	R:R:L269	R:R:T273	2.95	No	No	0	6	6
191	R:R:R271	R:R:R274	8.53	No	No	0	7	6
192	R:R:L275	R:R:L333	2.77	No	No	0	8	7
193	R:R:V279	R:R:Y330	6.31	No	Yes	0	8	9
194	R:R:F283	R:R:V284	6.55	Yes	No	0	9	6
195	R:R:T288	R:R:V284	3.17	Yes	No	0	5	6
196	R:R:C286	R:R:L318	3.17	No	No	0	8	8
197	R:R:C286	R:R:N322	9.45	No	Yes	0	8	9
198	R:R:I290	R:R:W287	3.52	No	Yes	1	6	8
199	R:R:G319	R:R:W287	7.04	No	Yes	1	7	8
200	R:R:N322	R:R:W287	22.6	Yes	Yes	1	9	8
201	R:R:P289	R:R:T288	3.5	No	Yes	0	9	5
202	R:R:C315	R:R:I290	3.27	No	No	0	7	6
203	R:R:E297	R:R:F293	13.99	No	No	0	5	5
204	R:R:F293	R:R:Y312	6.19	No	No	0	5	4
205	R:R:E297	R:R:S303	4.31	No	No	0	5	1
206	R:R:L309	R:R:S305	12.01	No	No	0	4	3
207	R:R:A307	R:R:T306	3.36	No	No	0	4	2
208	R:R:L309	R:R:Y312	2.34	No	No	0	4	4
209	R:R:F314	R:R:S310	3.96	No	No	0	5	2
210	R:R:I316	R:R:Y320	9.67	No	Yes	1	5	6
211	R:R:L318	R:R:T321	2.95	No	No	0	8	5
212	R:R:G319	R:R:N322	5.09	No	Yes	1	7	9
213	R:R:I328	R:R:S324	3.1	No	No	0	7	7
214	R:R:N326	R:R:Y330	9.3	No	Yes	1	9	9
215	R:R:L329	R:R:Y330	2.34	No	Yes	0	8	9
216	R:R:L329	R:R:L333	8.3	No	No	0	8	7
217	R:R:A331	R:R:F337	4.16	No	Yes	0	7	8
218	R:R:D334	R:R:F337	4.78	No	Yes	0	8	8
219	R:R:Q115	R:R:Y313	2.25	Yes	No	0	7	4
220	R:R:G197	R:R:G198	2.11	No	No	0	4	4
221	R:R:G73	R:R:V72	1.84	No	No	0	8	5
222	R:R:P172	R:R:T171	1.75	No	No	0	2	7
223	R:R:G197	R:R:K132	1.74	No	No	0	4	6
224	R:R:C340	R:R:V83	1.71	No	No	0	6	8
225	R:R:A104	R:R:S145	1.71	No	No	0	8	9
226	R:R:G127	R:R:L130	1.71	No	No	0	7	5
227	R:R:C245	R:R:V154	1.71	No	No	0	7	6
228	R:R:G300	R:R:L299	1.71	No	No	0	2	4
229	R:R:A331	R:R:V80	1.7	No	No	0	7	9
230	R:R:A106	R:R:T109	1.68	No	No	0	8	6
231	R:R:D128	R:R:G127	1.68	No	No	0	2	7
232	R:R:A308	R:R:T306	1.68	No	No	0	3	2
233	R:R:L196	R:R:P215	1.64	No	No	0	4	5
234	R:R:N326	R:R:P327	1.63	No	No	1	9	9
235	R:R:A175	R:R:I96	1.62	No	No	0	7	5
236	R:R:A166	R:R:I158	1.62	No	No	0	5	5
237	R:R:D216	R:R:P215	1.61	No	No	0	2	5
238	R:R:V65	R:R:V69	1.6	No	No	0	5	7
239	R:R:V71	R:R:V72	1.6	No	No	0	5	5
240	R:R:V278	R:R:V282	1.6	No	No	0	5	7
241	R:R:C181	R:R:L185	1.59	No	No	0	4	4
242	R:R:T302	R:R:V296	1.59	No	No	0	1	4
243	R:R:I61	R:R:V65	1.54	No	No	0	5	5
244	R:R:I243	R:R:V239	1.54	No	No	0	5	6
245	R:R:I243	R:R:V280	1.54	No	No	0	5	8
246	R:R:M121	R:R:S123	1.53	No	No	0	4	4
247	R:R:K132	R:R:S136	1.53	No	No	0	6	5
248	R:R:H162	R:R:P163	1.53	Yes	No	0	6	8
249	R:R:I292	R:R:T288	1.52	No	Yes	0	5	5
250	R:R:K91	R:R:T92	1.5	No	No	0	7	7
251	R:R:L184	R:R:S187	1.5	No	No	0	4	4
252	R:R:L253	R:R:V160	1.49	Yes	No	0	8	8
253	R:R:L196	R:R:V195	1.49	No	No	0	4	4
254	R:R:L253	R:R:V256	1.49	Yes	No	0	8	6
255	R:R:L277	R:R:V276	1.49	No	No	0	4	8
256	R:R:N322	R:R:V282	1.48	Yes	No	0	9	7
257	R:R:I58	R:R:I62	1.47	No	No	0	4	5
258	R:R:L120	R:R:T63	1.47	No	No	0	4	5
259	R:R:I133	R:R:I137	1.47	No	No	0	5	5
260	R:R:L173	R:R:T171	1.47	No	No	0	4	7
261	R:R:D218	R:R:S220	1.47	No	No	0	4	2
262	R:R:I232	R:R:I237	1.47	Yes	No	0	5	5
263	R:R:D266	R:R:S260	1.47	No	No	0	3	4
264	R:R:L277	R:R:T273	1.47	No	No	0	4	6
265	R:R:I96	R:R:M90	1.46	No	No	0	5	7
266	R:R:D206	R:R:V201	1.46	No	No	0	3	2
267	R:R:D155	R:R:T94	1.45	No	No	0	8	8
268	R:R:I294	R:R:K227	1.45	No	Yes	0	5	4
269	R:R:K89	R:R:K91	1.44	No	No	0	5	7
270	R:R:K227	R:R:M226	1.44	Yes	No	0	4	5
271	R:R:E264	R:R:S262	1.44	No	No	0	3	1
272	R:R:K265	R:R:N268	1.4	Yes	No	0	4	5
273	R:R:A166	R:R:R170	1.38	No	Yes	0	5	6
274	R:R:E335	R:R:K338	1.35	No	No	0	4	8
275	R:R:H162	R:R:K165	1.31	Yes	No	0	6	4
276	R:R:L333	R:R:R271	1.21	No	No	0	7	7
277	R:R:R267	R:R:R270	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.35333	12	1	0
2	R:R:Y66	3.89	4	5	6
3	R:R:Y97	3.685	4	0	7
4	R:R:Q115	4.27	5	1	7
5	R:R:Y119	8.21	4	5	4
6	R:R:W124	8.214	5	6	8
7	R:R:F126	5.09	5	0	7
8	R:R:Y140	5.6025	4	0	5
9	R:R:N141	5.23	4	0	8
10	R:R:M142	7.01	4	1	7
11	R:R:L149	3.2125	4	1	8
12	R:R:Y157	5.524	5	3	7
13	R:R:C161	4.615	4	3	7
14	R:R:H162	4.17	4	3	6
15	R:R:R170	6.29	4	0	6
16	R:R:R202	6.7925	4	7	2
17	R:R:F214	3.48	4	4	6
18	R:R:K227	3.218	5	0	4
19	R:R:I232	3.4725	4	9	5
20	R:R:F235	7.404	5	1	8
21	R:R:Y246	3.596	5	2	8
22	R:R:L253	2.82	4	0	8
23	R:R:K265	4.3475	4	10	4
24	R:R:F283	4.624	5	1	9
25	R:R:W287	8.03333	6	1	8
26	R:R:T288	3.345	4	0	5
27	R:R:Y320	6.195	6	1	6
28	R:R:N322	9.655	4	1	9
29	R:R:Y330	5.492	5	1	9
30	R:R:F337	4.4325	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q115	45.243	2.36	Yes	Yes	1	0	7
2	R:R:Q115	R:R:Y320	33.7343	5.64	Yes	Yes	1	7	6
3	R:R:M112	R:R:Y320	32.554	8.38	No	Yes	0	7	6
4	R:R:M112	R:R:V69	18.466	3.04	No	No	0	7	7
5	R:R:V65	R:R:V69	16.0903	1.6	No	No	0	5	7
6	R:R:I61	R:R:V65	12.0781	1.54	No	No	0	5	5
7	L:L:?1	R:R:D138	33.9153	4.81	Yes	No	0	0	6
8	R:R:D138	R:R:Y320	34.1906	3.45	No	Yes	0	6	6
9	L:L:?1	R:R:I316	32.9462	3.79	Yes	No	1	0	5
10	R:R:I316	R:R:Y320	31.9658	9.67	No	Yes	1	5	6
11	R:R:Q115	R:R:Y313	12.9907	2.25	Yes	No	0	7	4
12	R:R:Y119	R:R:Y313	11.8104	18.86	Yes	No	0	4	4
13	L:L:?1	R:R:W287	60.5377	5.05	Yes	Yes	1	0	8
14	R:R:F70	R:R:M112	10.8224	8.71	No	No	0	7	7
15	R:R:F235	R:R:W287	68.615	3.01	Yes	Yes	1	8	8
16	R:R:F235	R:R:F283	93.1672	6.43	Yes	Yes	1	8	9
17	R:R:F283	R:R:L149	100	2.44	Yes	Yes	1	9	8
18	R:R:L149	R:R:N326	13.809	4.12	Yes	No	1	8	9
19	R:R:N326	R:R:P327	15.4946	1.63	No	No	1	9	9
20	R:R:N77	R:R:P327	12.4251	6.52	No	No	1	9	9
21	R:R:N77	R:R:T109	10.9242	4.39	No	No	0	9	6
22	L:L:?1	R:R:H291	58.9577	14.81	Yes	No	0	0	8
23	R:R:F235	R:R:H291	58.7692	15.84	Yes	No	0	8	8
24	R:R:L149	R:R:Y330	62.3402	3.52	Yes	Yes	1	8	9
25	R:R:M152	R:R:Y330	59.1161	5.99	No	Yes	0	8	9
26	R:R:M152	R:R:Y97	57.1892	5.99	No	Yes	0	8	7
27	R:R:I178	R:R:Y97	49.21	2.42	No	Yes	0	6	7
28	R:R:F169	R:R:I178	46.7853	3.77	No	No	0	4	6
29	R:R:F169	R:R:I158	45.7974	5.02	No	No	0	4	5
30	R:R:A166	R:R:I158	34.4998	1.62	No	No	0	5	5
31	R:R:A166	R:R:R170	33.0819	1.38	No	Yes	0	5	6
32	R:R:D155	R:R:R170	28.7831	15.48	No	Yes	0	8	6
33	R:R:D155	R:R:T94	27.3351	1.45	No	No	0	8	8
34	R:R:T92	R:R:T94	25.8946	4.71	No	No	0	7	8
35	R:R:N95	R:R:T92	21.4827	13.16	No	No	0	7	7
36	R:R:N95	R:R:T88	19.997	5.85	No	No	0	7	6
37	R:R:L101	R:R:L149	26.5168	2.77	No	Yes	0	9	8
38	R:R:L101	R:R:T148	25.2423	5.9	No	No	0	9	7
39	R:R:N100	R:R:T148	23.1834	2.92	No	No	0	9	7
40	R:R:F99	R:R:N100	23.3003	4.83	No	No	0	5	9
41	R:R:F99	R:R:L103	17.2518	3.65	No	No	0	5	6
42	R:R:L103	R:R:W183	15.7208	2.28	No	No	0	6	9
43	R:R:T111	R:R:Y320	66.2544	6.24	No	Yes	1	7	6
44	R:R:F114	R:R:T111	59.5121	3.89	No	No	1	5	7
45	R:R:F114	R:R:F126	56.0579	6.43	No	Yes	0	5	7
46	R:R:F126	R:R:P125	10.8224	2.89	Yes	No	0	7	1
47	R:R:F126	R:R:W124	24.556	5.01	Yes	Yes	0	7	8
48	R:R:I208	R:R:W124	10.8224	12.92	No	Yes	0	4	8
49	R:R:F126	R:R:L130	14.4161	8.53	Yes	No	0	7	5
50	R:R:G127	R:R:L130	10.8224	1.71	No	No	0	7	5
51	R:R:M142	R:R:S145	11.9311	3.07	Yes	No	0	7	9
52	R:R:I146	R:R:S145	11.471	3.1	No	No	0	7	9
53	R:R:I146	R:R:P238	12.2101	3.39	No	No	0	7	9
54	R:R:F235	R:R:V239	30.6874	6.55	Yes	No	1	8	6
55	R:R:I243	R:R:V239	31.3021	1.54	No	No	0	5	6
56	R:R:I243	R:R:V280	30.299	1.54	No	No	0	5	8
57	R:R:V280	R:R:Y246	29.4694	2.52	No	Yes	0	8	8
58	R:R:M249	R:R:Y246	25.0801	3.59	No	Yes	2	8	8
59	R:R:I158	R:R:Y157	15.1175	3.63	No	Yes	0	5	7
60	R:R:M249	R:R:V160	28.802	7.61	No	No	0	8	8
61	R:R:L253	R:R:V160	27.7537	1.49	Yes	No	0	8	8
62	L:L:?1	R:R:I294	20.9359	15.18	Yes	No	0	0	5
63	R:R:I294	R:R:K227	19.5709	1.45	No	Yes	0	5	4
64	R:R:L253	R:R:L259	15.6454	4.15	Yes	No	0	8	3
65	R:R:K265	R:R:L259	12.5457	7.05	Yes	No	10	4	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q115	2.36	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I135	5.06	1	Yes	No	0	4	0	1
L:L:?1	R:R:D138	4.81	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y139	21.82	1	Yes	No	0	5	0	1
L:L:?1	R:R:M142	13.78	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F143	5.4	1	Yes	No	0	6	0	1
L:L:?1	R:R:W287	5.05	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I290	5.06	1	Yes	No	0	6	0	1
L:L:?1	R:R:H291	14.81	1	Yes	No	0	8	0	1
L:L:?1	R:R:I294	15.18	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y312	3.12	1	Yes	No	0	4	0	1
L:L:?1	R:R:I316	3.79	1	Yes	No	0	5	0	1
R:R:Q115	R:R:V118	2.87	1	Yes	No	7	5	1	2
R:R:I316	R:R:Q115	8.23	1	No	Yes	5	7	1	1
R:R:Q115	R:R:Y320	5.64	1	Yes	Yes	7	6	1	2
R:R:I135	R:R:Y139	2.42	1	No	No	4	5	1	1
R:R:D138	R:R:N141	4.04	0	No	Yes	6	8	1	2
R:R:D138	R:R:Y320	3.45	0	No	Yes	6	6	1	2
R:R:M142	R:R:N141	4.21	1	Yes	Yes	7	8	1	2
R:R:M142	R:R:S145	3.07	1	Yes	No	7	9	1	2
R:R:M142	R:R:W287	6.98	1	Yes	Yes	7	8	1	1
R:R:F143	R:R:V189	5.24	0	No	No	6	5	1	2
R:R:F143	R:R:V230	2.62	0	No	No	6	5	1	2
R:R:A234	R:R:H291	4.39	0	No	No	6	8	2	1
R:R:F235	R:R:W287	3.01	1	Yes	Yes	8	8	2	1
R:R:F235	R:R:H291	15.84	1	Yes	No	8	8	2	1
R:R:I290	R:R:W287	3.52	1	No	Yes	6	8	1	1
R:R:G319	R:R:W287	7.04	1	No	Yes	7	8	2	1
R:R:N322	R:R:W287	22.6	1	Yes	Yes	9	8	2	1
R:R:C315	R:R:I290	3.27	0	No	No	7	6	2	1
R:R:F293	R:R:Y312	6.19	0	No	No	5	4	2	1
R:R:L309	R:R:Y312	2.34	0	No	No	4	4	2	1
R:R:I316	R:R:Y320	9.67	1	No	Yes	5	6	1	2
R:R:G319	R:R:N322	5.09	1	No	Yes	7	9	2	2
R:R:Q115	R:R:Y313	2.25	1	Yes	No	7	4	1	2
R:R:I294	R:R:K227	1.45	0	No	Yes	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8VVG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.28
Number of Linked Nodes	260
Number of Links	277
Number of Hubs	30
Number of Links mediated by Hubs	124
Number of Communities	10
Number of Nodes involved in Communities	54
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	52591
Length Of Smallest Path	3
Average Path Length	14.2486
Length of Longest Path	31
Minimum Path Strength	1.42
Average Path Strength	5.31925
Maximum Path Strength	18.5
Minimum Path Correlation	0.7
Average Path Correlation	0.918163
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	44.0411
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.1841
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • defense response to virus • defense response • response to other organism • response to stress • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • response to acrylamide • response to chemical • response to oxygen-containing compound • response to nitrogen compound • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to hormone • response to endogenous stimulus • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • response to lipid • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • regulation of potassium ion transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • intracellular anatomical structure • cytoplasm • cytosol • presynapse • presynaptic membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • intracellular organelle • organelle • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • vesicle • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • organelle membrane • exocytic vesicle • mitochondrion • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • axon • axon terminus • distal axon • neuron projection terminus • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>8VVG_nogp_Chain_R A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	doi.org/10.1038/nature10939
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	doi.org/10.1016/j.cell.2017.12.011
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	doi.org/10.1038/s41467-020-14889-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	doi.org/10.1038/s41467-023-37041-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9V6O	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	Gi1/β1/γ2	2.76	2025-11-19	10.1038/s41467-025-64882-1
	9V6O (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-		2.76	2025-11-19	10.1038/s41467-025-64882-1
	9W49	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-	Gi1/β1/γ2	2.9	2025-11-19	10.1038/s41467-025-64882-1
	9W49 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-		2.9	2025-11-19	10.1038/s41467-025-64882-1
	9L60	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15	Gi1/β1/γ2	2.9	2025-12-31	To be published
	9L60 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15		2.9	2025-12-31	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8VVG_nogp.zip

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