psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G2	L:L:Y1	5.79	No	Yes	0	0	0
2	L:L:G3	L:L:Y1	2.9	No	Yes	0	0	0
3	L:L:Y1	R:R:Y139	10.92	Yes	No	0	0	5
4	L:L:Y1	R:R:M142	8.38	Yes	No	0	0	7
5	L:L:Y1	R:R:V230	6.31	Yes	No	0	0	5
6	L:L:Y1	R:R:I294	7.25	Yes	No	0	0	5
7	L:L:G2	R:R:I316	7.05	No	Yes	0	0	5
8	L:L:G3	L:L:L5	3.42	No	No	0	0	0
9	L:L:F4	R:R:Q115	10.54	No	Yes	0	0	7
10	L:L:F4	R:R:L135	6.09	No	No	0	0	4
11	L:L:F4	R:R:S211	2.64	No	No	0	0	4
12	L:L:L5	R:R:K227	7.05	No	No	0	0	4
13	L:L:R6	R:R:F214	4.28	No	No	0	0	6
14	L:L:R6	R:R:Y219	11.32	No	No	0	0	1
15	L:L:R6	R:R:D223	10.72	No	No	0	0	4
16	L:L:R7	R:R:L309	12.15	No	No	0	0	4
17	L:L:R7	R:R:Y312	16.46	No	Yes	0	0	4
18	L:L:I8	R:R:H304	9.28	No	No	0	0	1
19	L:L:R9	R:R:N122	14.46	No	No	0	0	5
20	L:L:R9	R:R:D206	4.76	No	No	0	0	3
21	R:R:I58	R:R:P59	5.08	No	No	0	4	4
22	R:R:I58	R:R:S310	9.29	No	No	0	4	2
23	R:R:I62	R:R:Y119	7.25	No	Yes	0	5	4
24	R:R:L120	R:R:T63	4.42	No	No	0	4	5
25	R:R:M112	R:R:Y66	3.59	Yes	Yes	2	7	6
26	R:R:Q115	R:R:Y66	5.64	Yes	Yes	2	7	6
27	R:R:S116	R:R:Y66	3.82	No	Yes	0	6	6
28	R:R:Y313	R:R:Y66	5.96	Yes	Yes	2	4	6
29	R:R:I316	R:R:Y66	6.04	Yes	Yes	2	5	6
30	R:R:A317	R:R:Y66	4	No	Yes	0	5	6
31	R:R:M112	R:R:V69	6.09	Yes	No	0	7	7
32	R:R:T321	R:R:V69	6.35	No	No	0	5	7
33	R:R:S324	R:R:V69	4.85	No	No	0	7	7
34	R:R:F70	R:R:V71	3.93	Yes	No	0	7	5
35	R:R:F70	R:R:L74	3.65	Yes	No	0	7	6
36	R:R:F70	R:R:M112	4.98	Yes	Yes	2	7	7
37	R:R:F70	R:R:P113	4.33	Yes	No	2	7	8
38	R:R:G73	R:R:S324	3.71	No	No	0	8	7
39	R:R:L74	R:R:T109	2.95	No	No	0	6	6
40	R:R:G76	R:R:P327	4.06	No	No	0	7	9
41	R:R:A102	R:R:N77	3.13	No	Yes	0	8	9
42	R:R:D105	R:R:N77	6.73	Yes	Yes	1	9	9
43	R:R:A106	R:R:N77	4.69	No	Yes	0	8	9
44	R:R:N77	R:R:T109	2.92	Yes	No	0	9	6
45	R:R:N77	R:R:P327	9.77	Yes	No	1	9	9
46	R:R:A102	R:R:V80	3.39	No	No	0	8	9
47	R:R:F99	R:R:M81	3.73	No	No	0	5	7
48	R:R:L103	R:R:M81	4.24	No	No	0	6	7
49	R:R:F82	R:R:R86	10.69	No	No	0	4	5
50	R:R:R339	R:R:V83	5.23	No	No	0	5	8
51	R:R:I84	R:R:K89	2.91	No	No	0	7	5
52	R:R:I84	R:R:N95	4.25	No	Yes	0	7	7
53	R:R:R339	R:R:Y87	5.14	No	No	0	5	5
54	R:R:K91	R:R:T88	12.01	No	No	0	7	6
55	R:R:K89	R:R:M90	5.76	No	No	0	5	7
56	R:R:F99	R:R:K89	9.93	No	No	0	5	5
57	R:R:K176	R:R:M90	2.88	No	No	0	4	7
58	R:R:T92	R:R:T94	10.99	No	Yes	6	7	8
59	R:R:N95	R:R:T92	8.77	Yes	No	6	7	7
60	R:R:A93	R:R:Y97	2.67	No	No	0	6	7
61	R:R:N95	R:R:T94	5.85	Yes	Yes	6	7	8
62	R:R:R170	R:R:T94	3.88	No	Yes	0	6	8
63	R:R:A175	R:R:I96	3.25	No	No	0	7	5
64	R:R:D155	R:R:Y97	9.2	No	No	0	8	7
65	R:R:N100	R:R:T148	4.39	No	No	0	9	7
66	R:R:N100	R:R:N179	17.71	No	No	4	9	7
67	R:R:N100	R:R:W183	5.65	No	Yes	4	9	9
68	R:R:D105	R:R:L101	4.07	Yes	Yes	1	9	9
69	R:R:L101	R:R:T148	8.84	Yes	No	0	9	7
70	R:R:L101	R:R:L149	2.77	Yes	No	1	9	8
71	R:R:L101	R:R:M152	4.24	Yes	No	0	9	8
72	R:R:L101	R:R:N326	2.75	Yes	Yes	1	9	9
73	R:R:L103	R:R:L107	4.15	No	No	0	6	6
74	R:R:L103	R:R:W183	6.83	No	Yes	0	6	9
75	R:R:A104	R:R:T144	3.36	No	Yes	0	8	7
76	R:R:D105	R:R:S145	4.42	Yes	No	1	9	9
77	R:R:D105	R:R:S323	7.36	Yes	No	1	9	8
78	R:R:D105	R:R:N326	12.12	Yes	Yes	1	9	9
79	R:R:D105	R:R:P327	3.22	Yes	No	1	9	9
80	R:R:L107	R:R:N141	13.73	No	No	0	6	8
81	R:R:V108	R:R:Y320	5.05	No	No	0	7	6
82	R:R:S323	R:R:V108	8.08	No	No	0	8	7
83	R:R:D138	R:R:T111	5.78	No	No	0	6	7
84	R:R:M112	R:R:P113	3.35	Yes	No	2	7	8
85	R:R:M112	R:R:Y320	3.59	Yes	No	0	7	6
86	R:R:F114	R:R:L130	4.87	No	No	0	5	5
87	R:R:F114	R:R:V134	10.49	No	No	0	5	6
88	R:R:Q115	R:R:Y313	5.64	Yes	Yes	2	7	4
89	R:R:I316	R:R:Q115	6.86	Yes	Yes	2	5	7
90	R:R:L120	R:R:Y119	3.52	No	Yes	0	4	4
91	R:R:L309	R:R:Y119	4.69	No	Yes	0	4	4
92	R:R:S310	R:R:Y119	6.36	No	Yes	0	2	4
93	R:R:Y119	R:R:Y313	23.83	Yes	Yes	0	4	4
94	R:R:M121	R:R:S123	4.6	No	No	0	4	4
95	R:R:F126	R:R:M121	3.73	No	No	0	7	4
96	R:R:F126	R:R:W124	3.01	No	No	0	7	8
97	R:R:P125	R:R:T199	3.5	No	No	7	1	4
98	R:R:I208	R:R:P125	6.77	No	No	0	4	1
99	R:R:C210	R:R:P125	3.77	No	No	7	9	1
100	R:R:D128	R:R:T199	5.78	No	No	0	2	4
101	R:R:C131	R:R:C210	7.28	No	No	0	9	9
102	R:R:G197	R:R:K132	3.49	No	No	0	4	6
103	R:R:G198	R:R:K132	5.23	No	No	0	4	6
104	R:R:L135	R:R:L212	5.54	No	No	0	4	4
105	R:R:A193	R:R:S136	3.42	No	No	0	5	5
106	R:R:I194	R:R:S136	7.74	No	No	0	4	5
107	R:R:I137	R:R:N141	5.66	No	No	0	5	8
108	R:R:D138	R:R:Y139	4.6	No	No	0	6	5
109	R:R:D138	R:R:Y320	10.34	No	No	0	6	6
110	R:R:N141	R:R:Y140	5.81	No	Yes	0	8	5
111	R:R:T144	R:R:Y140	6.24	Yes	Yes	4	7	5
112	R:R:W183	R:R:Y140	7.72	Yes	Yes	4	9	5
113	R:R:G190	R:R:Y140	2.9	No	Yes	0	6	5
114	R:R:I146	R:R:M142	4.37	Yes	No	1	7	7
115	R:R:M142	R:R:W287	6.98	No	Yes	1	7	8
116	R:R:F143	R:R:S186	2.64	Yes	No	0	6	8
117	R:R:F143	R:R:V189	5.24	Yes	No	0	6	5
118	R:R:F143	R:R:V230	5.24	Yes	No	0	6	5
119	R:R:T144	R:R:W183	12.13	Yes	Yes	4	7	9
120	R:R:S186	R:R:T144	7.99	No	Yes	0	8	7
121	R:R:S145	R:R:S323	3.26	No	No	1	9	8
122	R:R:I146	R:R:P238	3.39	Yes	Yes	1	7	9
123	R:R:F283	R:R:I146	3.77	Yes	Yes	1	9	7
124	R:R:I146	R:R:W287	5.87	Yes	Yes	1	7	8
125	R:R:F147	R:R:L185	3.65	No	No	0	6	4
126	R:R:L149	R:R:N326	6.87	No	Yes	1	8	9
127	R:R:L149	R:R:Y330	3.52	No	Yes	1	8	9
128	R:R:P238	R:R:T150	3.5	Yes	No	0	9	7
129	R:R:I241	R:R:T150	4.56	No	No	0	6	7
130	R:R:I178	R:R:M151	2.92	No	No	0	6	6
131	R:R:M152	R:R:Y330	3.59	No	Yes	0	8	9
132	R:R:I242	R:R:S153	7.74	No	No	0	8	9
133	R:R:S153	R:R:Y246	5.09	No	Yes	0	9	8
134	R:R:D155	R:R:R170	11.91	No	No	0	8	6
135	R:R:R156	R:R:Y246	9.26	No	Yes	0	9	8
136	R:R:R156	R:R:Y330	8.23	No	Yes	0	9	9
137	R:R:I158	R:R:Y157	3.63	No	Yes	0	5	7
138	R:R:C161	R:R:Y157	12.1	No	Yes	8	7	7
139	R:R:H162	R:R:Y157	5.44	Yes	Yes	8	6	7
140	R:R:C245	R:R:Y157	6.72	Yes	Yes	0	7	7
141	R:R:L248	R:R:Y157	7.03	No	Yes	0	4	7
142	R:R:F169	R:R:I158	3.77	No	No	0	4	5
143	R:R:A159	R:R:R170	2.77	No	No	0	8	6
144	R:R:M249	R:R:V160	6.09	No	No	0	8	8
145	R:R:C161	R:R:H162	4.42	No	Yes	8	7	6
146	R:R:C161	R:R:R252	8.36	No	No	0	7	5
147	R:R:K165	R:R:V164	3.04	No	No	0	4	5
148	R:R:P172	R:R:T171	3.5	No	No	0	2	7
149	R:R:I177	R:R:L173	4.28	No	No	0	3	4
150	R:R:I180	R:R:K176	2.91	No	No	0	4	4
151	R:R:I182	R:R:N179	2.83	No	No	0	7	7
152	R:R:N179	R:R:W183	9.04	No	Yes	4	7	9
153	R:R:L184	R:R:S187	3	No	No	0	4	4
154	R:R:L196	R:R:V195	2.98	No	No	0	4	4
155	R:R:L196	R:R:P215	3.28	No	Yes	3	4	5
156	R:R:L196	R:R:W222	3.42	No	No	3	4	7
157	R:R:G198	R:R:Q213	4.93	No	No	0	4	4
158	R:R:C210	R:R:T199	3.38	No	No	7	9	4
159	R:R:K200	R:R:Q213	4.07	No	No	0	2	4
160	R:R:I208	R:R:V201	4.61	No	No	0	4	2
161	R:R:R202	R:R:V205	3.92	Yes	No	0	2	1
162	R:R:D206	R:R:R202	9.53	No	Yes	0	3	2
163	R:R:E209	R:R:R202	11.63	No	Yes	0	3	2
164	R:R:D206	R:R:V207	2.92	No	No	0	3	3
165	R:R:E209	R:R:S211	7.19	No	No	0	3	4
166	R:R:D216	R:R:P215	3.22	No	Yes	3	2	5
167	R:R:P215	R:R:W222	9.46	Yes	No	3	5	7
168	R:R:D216	R:R:D217	5.32	No	No	3	2	1
169	R:R:D216	R:R:D218	6.65	No	No	3	2	4
170	R:R:D217	R:R:D218	6.65	No	No	3	1	4
171	R:R:S220	R:R:Y219	3.82	No	No	0	2	1
172	R:R:C229	R:R:F225	8.38	No	No	0	3	4
173	R:R:I294	R:R:K227	5.82	No	No	0	5	4
174	R:R:F231	R:R:F235	5.36	Yes	Yes	1	5	8
175	R:R:F231	R:R:V236	3.93	Yes	No	0	5	4
176	R:R:F231	R:R:H291	6.79	Yes	No	1	5	8
177	R:R:F231	R:R:L295	9.74	Yes	No	0	5	5
178	R:R:F233	R:R:I232	3.77	No	No	0	4	5
179	R:R:I232	R:R:V236	4.61	No	No	0	5	4
180	R:R:F235	R:R:V239	7.87	Yes	No	0	8	6
181	R:R:F235	R:R:T288	5.19	Yes	Yes	0	8	5
182	R:R:F235	R:R:H291	3.39	Yes	No	1	8	8
183	R:R:I237	R:R:P238	3.39	No	Yes	0	5	9
184	R:R:I237	R:R:I241	2.94	No	No	0	5	6
185	R:R:F283	R:R:P238	2.89	Yes	Yes	1	9	9
186	R:R:I243	R:R:V239	3.07	No	No	0	5	6
187	R:R:V239	R:R:V284	3.21	No	No	0	6	6
188	R:R:I242	R:R:V280	3.07	No	No	0	8	8
189	R:R:I243	R:R:V280	4.61	No	No	0	5	8
190	R:R:V276	R:R:Y246	12.62	No	Yes	0	8	8
191	R:R:V279	R:R:Y246	5.05	No	Yes	0	8	8
192	R:R:L251	R:R:T247	2.95	No	No	0	4	4
193	R:R:I250	R:R:M249	2.92	No	No	0	5	8
194	R:R:I250	R:R:T273	9.12	No	No	0	5	6
195	R:R:I250	R:R:V276	4.61	No	No	0	5	8
196	R:R:L253	R:R:V256	2.98	Yes	No	5	8	6
197	R:R:L253	R:R:L259	4.15	Yes	No	5	8	3
198	R:R:L253	R:R:L269	4.15	Yes	No	5	8	6
199	R:R:I272	R:R:L253	4.28	No	Yes	0	7	8
200	R:R:K254	R:R:L269	2.82	No	No	0	4	6
201	R:R:L259	R:R:V256	4.47	No	No	5	3	6
202	R:R:L259	R:R:L269	9.69	No	No	5	3	6
203	R:R:G261	R:R:S260	3.71	No	No	0	3	4
204	R:R:K265	R:R:S262	9.18	No	No	0	4	1
205	R:R:E264	R:R:R263	3.49	No	No	0	3	3
206	R:R:D266	R:R:R270	3.57	No	No	0	3	5
207	R:R:N268	R:R:R267	3.62	No	Yes	9	5	4
208	R:R:R267	R:R:R270	4.26	Yes	No	0	4	5
209	R:R:R267	R:R:R271	7.46	Yes	No	9	4	7
210	R:R:N268	R:R:R271	9.64	No	No	9	5	7
211	R:R:R270	R:R:R274	3.2	No	No	0	5	6
212	R:R:E335	R:R:R271	3.49	No	No	0	4	7
213	R:R:L275	R:R:V278	4.47	No	No	0	8	5
214	R:R:L329	R:R:V278	4.47	No	No	0	8	5
215	R:R:V279	R:R:Y330	8.83	No	Yes	0	8	9
216	R:R:L329	R:R:V282	4.47	No	No	0	8	7
217	R:R:F283	R:R:W287	7.02	Yes	Yes	1	9	8
218	R:R:F283	R:R:N322	4.83	Yes	Yes	1	9	9
219	R:R:T288	R:R:V284	4.76	Yes	No	0	5	6
220	R:R:C286	R:R:N322	6.3	No	Yes	0	8	9
221	R:R:H291	R:R:W287	9.52	No	Yes	1	8	8
222	R:R:G319	R:R:W287	8.44	No	Yes	0	7	8
223	R:R:N322	R:R:W287	9.04	Yes	Yes	1	9	8
224	R:R:P289	R:R:T288	3.5	No	Yes	0	9	5
225	R:R:I292	R:R:T288	3.04	No	Yes	0	5	5
226	R:R:C315	R:R:P289	7.53	No	No	0	7	9
227	R:R:I290	R:R:I294	5.89	No	No	0	6	5
228	R:R:C315	R:R:I290	4.91	No	No	0	7	6
229	R:R:I290	R:R:I316	2.94	No	Yes	0	6	5
230	R:R:E297	R:R:F293	5.83	No	Yes	2	5	5
231	R:R:F293	R:R:Y312	13.41	Yes	Yes	2	5	4
232	R:R:E297	R:R:Y312	5.61	No	Yes	2	5	4
233	R:R:Y312	R:R:Y313	8.94	Yes	Yes	2	4	4
234	R:R:I316	R:R:Y312	4.84	Yes	Yes	2	5	4
235	R:R:I316	R:R:Y313	6.04	Yes	Yes	2	5	4
236	R:R:F314	R:R:L318	6.09	No	No	0	5	8
237	R:R:N322	R:R:N326	9.54	Yes	Yes	1	9	9
238	R:R:I328	R:R:L325	5.71	No	No	0	7	6
239	R:R:N326	R:R:Y330	3.49	Yes	Yes	1	9	9
240	R:R:L329	R:R:Y330	3.52	No	Yes	0	8	9
241	R:R:F332	R:R:L333	4.87	No	No	0	6	7
242	R:R:F332	R:R:F337	3.22	No	No	0	6	8
243	R:R:D334	R:R:N336	6.73	No	No	0	8	6
244	R:R:K338	R:R:N336	2.8	No	No	0	8	6
245	R:R:F314	R:R:V65	2.62	No	No	0	5	5
246	R:R:R86	R:R:V83	2.62	No	No	0	5	8
247	R:R:V118	R:R:Y313	2.52	No	Yes	0	5	4
248	R:R:T88	R:R:Y87	2.5	No	No	0	6	5
249	R:R:K200	R:R:R202	2.48	No	Yes	0	2	2
250	R:R:I178	R:R:Y97	2.42	No	No	0	6	7
251	R:R:I98	R:R:Y330	2.42	No	Yes	0	8	9
252	R:R:M226	R:R:Y139	2.39	No	No	0	5	5
253	R:R:N95	R:R:Y87	2.33	Yes	No	0	7	5
254	R:R:E264	R:R:R267	2.33	No	Yes	0	3	4
255	R:R:F143	R:R:F147	2.14	Yes	No	0	6	6
256	R:R:F337	R:R:R339	2.14	No	No	0	8	5
257	R:R:G190	R:R:S136	1.86	No	No	0	6	5
258	R:R:G261	R:R:S262	1.86	No	No	0	3	1
259	R:R:G300	R:R:S303	1.86	No	No	0	2	1
260	R:R:G73	R:R:V72	1.84	No	No	0	8	5
261	R:R:G76	R:R:V75	1.84	No	No	0	7	4
262	R:R:A175	R:R:A93	1.79	No	No	0	7	6
263	R:R:C245	R:R:S153	1.72	Yes	No	0	7	9
264	R:R:G127	R:R:L130	1.71	No	No	0	7	5
265	R:R:C245	R:R:V154	1.71	Yes	No	0	7	6
266	R:R:C245	R:R:V244	1.71	Yes	No	0	7	4
267	R:R:A307	R:R:S305	1.71	No	No	0	4	3
268	R:R:A308	R:R:S305	1.71	No	No	0	3	3
269	R:R:G319	R:R:L318	1.71	No	No	0	7	8
270	R:R:A57	R:R:V60	1.7	No	No	0	4	5
271	R:R:A331	R:R:V80	1.7	No	No	0	7	9
272	R:R:A234	R:R:V230	1.7	No	No	0	6	5
273	R:R:D128	R:R:G198	1.68	No	No	0	2	4
274	R:R:S123	R:R:V207	1.62	No	No	0	4	3
275	R:R:A166	R:R:I158	1.62	No	No	0	5	5
276	R:R:S116	R:R:T117	1.6	No	No	0	6	4
277	R:R:S301	R:R:T302	1.6	No	No	0	2	1
278	R:R:T111	R:R:V134	1.59	No	No	0	7	6
279	R:R:T110	R:R:T111	1.57	No	No	0	4	7
280	R:R:I328	R:R:V72	1.54	No	No	0	7	5
281	R:R:I133	R:R:V129	1.54	No	No	0	5	1
282	R:R:I133	R:R:V134	1.54	No	No	0	5	6
283	R:R:H162	R:R:P163	1.53	Yes	No	0	6	8
284	R:R:I243	R:R:T247	1.52	No	No	0	5	4
285	R:R:K174	R:R:T171	1.5	No	No	0	5	7
286	R:R:L79	R:R:V75	1.49	No	No	0	6	4
287	R:R:L253	R:R:V160	1.49	Yes	No	0	8	8
288	R:R:L258	R:R:V256	1.49	No	No	0	5	6
289	R:R:L277	R:R:V276	1.49	No	No	0	4	8
290	R:R:I84	R:R:I85	1.47	No	No	0	7	3
291	R:R:L173	R:R:T171	1.47	No	No	0	4	7
292	R:R:I177	R:R:I178	1.47	No	No	0	3	6
293	R:R:I228	R:R:I232	1.47	No	No	0	5	5
294	R:R:N336	R:R:T94	1.46	No	Yes	0	6	8
295	R:R:D204	R:R:V205	1.46	No	No	0	2	1
296	R:R:F214	R:R:P215	1.44	No	Yes	0	6	5
297	R:R:E264	R:R:S262	1.44	No	No	0	3	1
298	R:R:E297	R:R:S303	1.44	No	No	0	5	1
299	R:R:I241	R:R:L240	1.43	No	No	0	6	3
300	R:R:K265	R:R:L258	1.41	No	No	0	4	5
301	R:R:A308	R:R:F293	1.39	No	Yes	0	3	5
302	R:R:D168	R:R:K174	1.38	No	No	0	4	5
303	R:R:D223	R:R:L212	1.36	No	No	0	4	4
304	R:R:R257	R:R:S260	1.32	No	No	0	4	4
305	R:R:F293	R:R:S311	1.32	Yes	No	0	5	4
306	R:R:H162	R:R:K165	1.31	Yes	No	0	6	4
307	R:R:D204	R:R:E203	1.3	No	No	0	2	1
308	R:R:S187	R:R:Y140	1.27	No	Yes	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	6.925	6	0	0
2	R:R:Y66	4.84167	6	2	6
3	R:R:F70	4.2225	4	2	7
4	R:R:N77	5.448	5	1	9
5	R:R:T94	5.545	4	6	8
6	R:R:N95	5.3	4	6	7
7	R:R:L101	4.534	5	1	9
8	R:R:D105	6.32	6	1	9
9	R:R:M112	4.32	5	2	7
10	R:R:Q115	7.17	4	2	7
11	R:R:Y119	9.13	5	0	4
12	R:R:Y140	4.788	5	4	5
13	R:R:F143	3.815	4	0	6
14	R:R:T144	7.43	4	4	7
15	R:R:I146	4.35	4	1	7
16	R:R:Y157	6.984	5	8	7
17	R:R:H162	3.175	4	8	6
18	R:R:W183	8.274	5	4	9
19	R:R:R202	6.89	4	0	2
20	R:R:P215	4.35	4	3	5
21	R:R:F231	6.455	4	1	5
22	R:R:F235	5.4525	4	1	8
23	R:R:P238	3.2925	4	1	9
24	R:R:C245	2.965	4	0	7
25	R:R:Y246	8.005	4	0	8
26	R:R:L253	3.41	5	5	8
27	R:R:R267	4.4175	4	9	4
28	R:R:F283	4.6275	4	1	9
29	R:R:W287	7.81167	6	1	8
30	R:R:T288	4.1225	4	0	5
31	R:R:F293	5.4875	4	2	5
32	R:R:Y312	9.852	5	2	4
33	R:R:Y313	8.82167	6	2	4
34	R:R:I316	5.62833	6	2	5
35	R:R:N322	7.4275	4	1	9
36	R:R:N326	6.954	5	1	9
37	R:R:Y330	4.8	7	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G2	L:L:Y1	54.7581	5.79	No	Yes	0	0	0
2	L:L:Y1	R:R:M142	46.2914	8.38	Yes	No	0	0	7
3	L:L:Y1	R:R:V230	30.6895	6.31	Yes	No	0	0	5
4	L:L:F4	R:R:Q115	71.5092	10.54	No	Yes	0	0	7
5	R:R:I316	R:R:Q115	44.6901	6.86	Yes	Yes	2	5	7
6	L:L:G2	R:R:I316	54.2147	7.05	No	Yes	0	0	5
7	L:L:F4	R:R:L135	25.9603	6.09	No	No	0	0	4
8	L:L:F4	R:R:S211	47.0588	2.64	No	No	0	0	4
9	R:R:L135	R:R:L212	24.301	5.54	No	No	0	4	4
10	R:R:D223	R:R:L212	22.4674	1.36	No	No	0	4	4
11	L:L:R6	R:R:D223	20.7998	10.72	No	No	0	0	4
12	L:L:R6	R:R:F214	15.2286	4.28	No	No	0	0	6
13	R:R:I316	R:R:Y312	15.4318	4.84	Yes	Yes	2	5	4
14	R:R:I316	R:R:Y313	10.2008	6.04	Yes	Yes	2	5	4
15	R:R:Y119	R:R:Y313	14.6478	23.83	Yes	Yes	0	4	4
16	R:R:E209	R:R:S211	45.3207	7.19	No	No	0	3	4
17	R:R:E209	R:R:R202	43.6696	11.63	No	Yes	0	3	2
18	R:R:D206	R:R:R202	14.9506	9.53	No	Yes	0	3	2
19	R:R:M112	R:R:Y66	39.6914	3.59	Yes	Yes	2	7	6
20	R:R:M112	R:R:V69	11.2047	6.09	Yes	No	0	7	7
21	R:R:M142	R:R:W287	41.247	6.98	No	Yes	1	7	8
22	R:R:N322	R:R:W287	44.52	9.04	Yes	Yes	1	9	8
23	R:R:N322	R:R:N326	51.5266	9.54	Yes	Yes	1	9	9
24	R:R:D105	R:R:N326	40.2016	12.12	Yes	Yes	1	9	9
25	R:R:F143	R:R:V230	28.9886	5.24	Yes	No	0	6	5
26	R:R:F143	R:R:S186	25.7861	2.64	Yes	No	0	6	8
27	R:R:S186	R:R:T144	26.6365	7.99	No	Yes	0	8	7
28	R:R:T144	R:R:W183	22.4882	12.13	Yes	Yes	4	7	9
29	R:R:L103	R:R:W183	79.5238	6.83	No	Yes	0	6	9
30	R:R:L103	R:R:M81	76.3005	4.24	No	No	0	6	7
31	R:R:F99	R:R:M81	74.4918	3.73	No	No	0	5	7
32	R:R:F99	R:R:K89	72.6749	9.93	No	No	0	5	5
33	R:R:I84	R:R:K89	65.324	2.91	No	No	0	7	5
34	R:R:I84	R:R:N95	61.5988	4.25	No	Yes	0	7	7
35	R:R:N95	R:R:Y87	20.862	2.33	Yes	No	0	7	5
36	R:R:R339	R:R:Y87	14.6893	5.14	No	No	0	5	5
37	R:R:N95	R:R:T94	38.4717	5.85	Yes	Yes	6	7	8
38	R:R:R170	R:R:T94	30.7807	3.88	No	Yes	0	6	8
39	R:R:D155	R:R:R170	26.9518	11.91	No	No	0	8	6
40	R:R:D155	R:R:Y97	24.915	9.2	No	No	0	8	7
41	R:R:N100	R:R:W183	80.5609	5.65	No	Yes	4	9	9
42	R:R:L101	R:R:N326	32.2202	2.75	Yes	Yes	1	9	9
43	R:R:L101	R:R:T148	86.5801	8.84	Yes	No	0	9	7
44	R:R:L101	R:R:M152	24.8569	4.24	Yes	No	0	9	8
45	R:R:N326	R:R:Y330	100	3.49	Yes	Yes	1	9	9
46	R:R:M152	R:R:Y330	24.4711	3.59	No	Yes	0	8	9
47	R:R:D138	R:R:Y320	10.4621	10.34	No	No	0	6	6
48	R:R:V108	R:R:Y320	37.6794	5.05	No	No	0	7	6
49	R:R:S323	R:R:V108	38.0237	8.08	No	No	0	8	7
50	R:R:M112	R:R:Y320	38.1606	3.59	Yes	No	0	7	6
51	R:R:D138	R:R:T111	11.0802	5.78	No	No	0	6	7
52	R:R:K200	R:R:R202	22.6292	2.48	No	Yes	0	2	2
53	R:R:K200	R:R:Q213	20.8039	4.07	No	No	0	2	4
54	R:R:G198	R:R:Q213	18.9538	4.93	No	No	0	4	4
55	R:R:D128	R:R:G198	13.3535	1.68	No	No	0	2	4
56	R:R:D128	R:R:T199	11.4702	5.78	No	No	0	2	4
57	R:R:I178	R:R:Y97	16.7344	2.42	No	No	0	6	7
58	R:R:H291	R:R:W287	14.2745	9.52	No	Yes	1	8	8
59	R:R:F235	R:R:V239	11.5324	7.87	Yes	No	0	8	6
60	R:R:I243	R:R:V239	16.834	3.07	No	No	0	5	6
61	R:R:I243	R:R:V280	13.6978	4.61	No	No	0	5	8
62	R:R:I242	R:R:V280	14.5773	3.07	No	No	0	8	8
63	R:R:R156	R:R:Y330	70.555	8.23	No	Yes	0	9	9
64	R:R:R156	R:R:Y246	69.2732	9.26	No	Yes	0	9	8
65	R:R:S153	R:R:Y246	54.6669	5.09	No	Yes	0	9	8
66	R:R:V279	R:R:Y330	70.6961	8.83	No	Yes	0	8	9
67	R:R:V279	R:R:Y246	69.3022	5.05	No	Yes	0	8	8
68	R:R:C245	R:R:S153	53.8911	1.72	Yes	No	0	7	9
69	R:R:C245	R:R:Y157	42.4044	6.72	Yes	Yes	0	7	7
70	R:R:I158	R:R:Y157	11.7564	3.63	No	Yes	0	5	7
71	R:R:H162	R:R:Y157	15.6268	5.44	Yes	Yes	8	6	7
72	R:R:V276	R:R:Y246	89.4964	12.62	No	Yes	0	8	8
73	R:R:I250	R:R:V276	83.1453	4.61	No	No	0	5	8
74	R:R:I250	R:R:M249	76.6282	2.92	No	No	0	5	8
75	R:R:M249	R:R:V160	73.3552	6.09	No	No	0	8	8
76	R:R:I177	R:R:I178	12.6068	1.47	No	No	0	3	6
77	R:R:I177	R:R:L173	10.5244	4.28	No	No	0	3	4
78	R:R:F214	R:R:P215	13.3535	1.44	No	Yes	0	6	5
79	R:R:I290	R:R:I316	17.2156	2.94	No	Yes	0	6	5
80	R:R:C315	R:R:I290	17.3899	4.91	No	No	0	7	6
81	R:R:C315	R:R:P289	17.0538	7.53	No	No	0	7	9
82	R:R:P289	R:R:T288	17.0331	3.5	No	Yes	0	9	5
83	R:R:L253	R:R:V160	70.2107	1.49	Yes	No	0	8	8
84	R:R:L253	R:R:V256	54.1442	2.98	Yes	No	5	8	6
85	R:R:L258	R:R:V256	51.008	1.49	No	No	0	5	6
86	R:R:K265	R:R:L258	47.6645	1.41	No	No	0	4	5
87	R:R:K265	R:R:S262	44.3126	9.18	No	No	0	4	1
88	R:R:G261	R:R:S262	10.3501	1.86	No	No	0	3	1
89	R:R:E264	R:R:S262	30.8222	1.44	No	No	0	3	1
90	R:R:E264	R:R:R267	24.0272	2.33	No	Yes	0	3	4
91	R:R:R267	R:R:R270	10.3501	4.26	Yes	No	0	4	5
92	R:R:F235	R:R:T288	11.3374	5.19	Yes	Yes	0	8	5
93	R:R:D105	R:R:S323	37.92	7.36	Yes	No	1	9	8
94	R:R:N100	R:R:T148	84.8876	4.39	No	No	0	9	7
95	R:R:I242	R:R:S153	15.8259	7.74	No	No	0	8	9
96	R:R:Q115	R:R:Y66	24.9606	5.64	Yes	Yes	2	7	6
97	R:R:L101	R:R:L149	24.5333	2.77	Yes	No	1	9	8
98	R:R:W183	R:R:Y140	14.6727	7.72	Yes	Yes	4	9	5
99	R:R:L149	R:R:Y330	24.2886	3.52	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:Y139	10.92	0	Yes	No	0	5	0	1
L:L:Y1	R:R:M142	8.38	0	Yes	No	0	7	0	1
L:L:Y1	R:R:V230	6.31	0	Yes	No	0	5	0	1
L:L:Y1	R:R:I294	7.25	0	Yes	No	0	5	0	1
L:L:G2	R:R:I316	7.05	0	No	Yes	0	5	0	1
L:L:F4	R:R:Q115	10.54	0	No	Yes	0	7	0	1
L:L:F4	R:R:L135	6.09	0	No	No	0	4	0	1
L:L:F4	R:R:S211	2.64	0	No	No	0	4	0	1
L:L:L5	R:R:K227	7.05	0	No	No	0	4	0	1
L:L:R6	R:R:F214	4.28	0	No	No	0	6	0	1
L:L:R6	R:R:Y219	11.32	0	No	No	0	1	0	1
L:L:R6	R:R:D223	10.72	0	No	No	0	4	0	1
L:L:R7	R:R:L309	12.15	0	No	No	0	4	0	1
L:L:R7	R:R:Y312	16.46	0	No	Yes	0	4	0	1
L:L:I8	R:R:H304	9.28	0	No	No	0	1	0	1
L:L:R9	R:R:N122	14.46	0	No	No	0	5	0	1
L:L:R9	R:R:D206	4.76	0	No	No	0	3	0	1
R:R:Q115	R:R:Y66	5.64	2	Yes	Yes	7	6	1	2
R:R:Y313	R:R:Y66	5.96	2	Yes	Yes	4	6	2	2
R:R:I316	R:R:Y66	6.04	2	Yes	Yes	5	6	1	2
R:R:Q115	R:R:Y313	5.64	2	Yes	Yes	7	4	1	2
R:R:I316	R:R:Q115	6.86	2	Yes	Yes	5	7	1	1
R:R:L309	R:R:Y119	4.69	0	No	Yes	4	4	1	2
R:R:Y119	R:R:Y313	23.83	0	Yes	Yes	4	4	2	2
R:R:L135	R:R:L212	5.54	0	No	No	4	4	1	2
R:R:D138	R:R:Y139	4.6	0	No	No	6	5	2	1
R:R:I146	R:R:M142	4.37	1	Yes	No	7	7	2	1
R:R:M142	R:R:W287	6.98	1	No	Yes	7	8	1	2
R:R:F143	R:R:V230	5.24	0	Yes	No	6	5	2	1
R:R:I146	R:R:W287	5.87	1	Yes	Yes	7	8	2	2
R:R:D206	R:R:R202	9.53	0	No	Yes	3	2	1	2
R:R:E209	R:R:R202	11.63	0	No	Yes	3	2	2	2
R:R:D206	R:R:V207	2.92	0	No	No	3	3	1	2
R:R:E209	R:R:S211	7.19	0	No	No	3	4	2	1
R:R:S220	R:R:Y219	3.82	0	No	No	2	1	2	1
R:R:I294	R:R:K227	5.82	0	No	No	5	4	1	1
R:R:I290	R:R:I294	5.89	0	No	No	6	5	2	1
R:R:I290	R:R:I316	2.94	0	No	Yes	6	5	2	1
R:R:E297	R:R:F293	5.83	2	No	Yes	5	5	2	2
R:R:F293	R:R:Y312	13.41	2	Yes	Yes	5	4	2	1
R:R:E297	R:R:Y312	5.61	2	No	Yes	5	4	2	1
R:R:Y312	R:R:Y313	8.94	2	Yes	Yes	4	4	1	2
R:R:I316	R:R:Y312	4.84	2	Yes	Yes	5	4	1	1
R:R:I316	R:R:Y313	6.04	2	Yes	Yes	5	4	1	2
R:R:M226	R:R:Y139	2.39	0	No	No	5	5	2	1
R:R:A234	R:R:V230	1.7	0	No	No	6	5	2	1
R:R:F214	R:R:P215	1.44	0	No	Yes	6	5	1	2
R:R:D223	R:R:L212	1.36	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7Y1F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	273
Number of Links	308
Number of Hubs	37
Number of Links mediated by Hubs	140
Number of Communities	9
Number of Nodes involved in Communities	55
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	67449
Length Of Smallest Path	3
Average Path Length	16.6306
Length of Longest Path	37
Minimum Path Strength	1.38
Average Path Strength	5.75728
Maximum Path Strength	16.385
Minimum Path Correlation	0.7
Average Path Correlation	0.925472
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	44.5034
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.7517
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • opioid peptide activity • molecular transducer activity • binding • molecular function activator activity • signaling receptor binding • signaling receptor activity • signaling receptor activator activity • protein binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • multicellular organismal process • system process • sensory perception • nervous system process • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • somatodendritic compartment • cell body • neuronal cell body • dendrite • dendritic tree • neuron projection • axon • axon terminus • presynapse • distal axon • neuron projection terminus • neuropeptide binding • peptide binding • peptide receptor activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • G protein-coupled peptide receptor activity • dynorphin receptor activity • receptor serine/threonine kinase binding • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • G protein-coupled opioid receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to virus • defense response to other organism • response to stress • response to external biotic stimulus • response to virus • response to acrylamide • response to chemical • response to oxygen-containing compound • response to nitrogen compound • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to hormone • response to endogenous stimulus • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • response to lipid • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • inorganic ion transmembrane transport • regulation of potassium ion transmembrane transport • inorganic cation transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • perikaryon • presynaptic membrane • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • transport vesicle membrane • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • exocytic vesicle • mitochondrion • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>7Y1F_nogp_Chain_R P A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	10.1101/2025.01.09.632033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	10.1101/2025.01.09.632033
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	10.1038/s41467-023-43718-w
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	10.1093/procel/pwac033
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	10.1038/s41586-023-06030-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	10.1038/s41586-023-06030-7
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	10.1038/s41467-023-37041-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	10.1016/j.cell.2022.12.026
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	10.1038/s41467-020-14889-7
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	10.1016/j.cell.2017.12.011
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	10.1038/nature10939
	4DJH (Multimeric)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		2.9	2012-03-21	10.1038/nature10939

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