Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:Y1 6.925600
2R:R:Y66 4.84167626
3R:R:F70 4.2225427
4R:R:N77 5.448519
5R:R:T94 5.545468
6R:R:N95 5.3467
7R:R:L101 4.534519
8R:R:D105 6.32619
9R:R:M112 4.32527
10R:R:Q115 7.17427
11R:R:Y119 9.13504
12R:R:Y140 4.788545
13R:R:F143 3.815406
14R:R:T144 7.43447
15R:R:I146 4.35417
16R:R:Y157 6.984587
17R:R:H162 3.175486
18R:R:W183 8.274549
19R:R:R202 6.89402
20R:R:P215 4.35435
21R:R:F231 6.455415
22R:R:F235 5.4525418
23R:R:P238 3.2925419
24R:R:C245 2.965407
25R:R:Y246 8.005408
26R:R:L253 3.41558
27R:R:R267 4.4175494
28R:R:F283 4.6275419
29R:R:W287 7.81167618
30R:R:T288 4.1225405
31R:R:F293 5.4875425
32R:R:Y312 9.852524
33R:R:Y313 8.82167624
34R:R:I316 5.62833625
35R:R:N322 7.4275419
36R:R:N326 6.954519
37R:R:Y330 4.8719
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:G2 L:L:Y1 54.73565.79NoYes000
2L:L:Y1 R:R:M142 46.26468.38YesNo007
3L:L:Y1 R:R:V230 30.70476.31YesNo005
4L:L:F4 R:R:Q115 71.49510.54NoYes007
5R:R:I316 R:R:Q115 44.66266.86YesYes257
6L:L:G2 R:R:I316 54.19197.05NoYes005
7L:L:F4 R:R:L135 25.97336.09NoNo004
8L:L:F4 R:R:S211 47.03252.64NoNo004
9R:R:L135 R:R:L212 24.31315.54NoNo044
10R:R:D223 R:R:L212 22.47861.36NoNo044
11L:L:R6 R:R:D223 20.810210.72NoNo004
12L:L:R6 R:R:F214 15.23624.28NoNo006
13R:R:I316 R:R:Y312 15.43954.84YesYes254
14R:R:I316 R:R:Y313 10.20596.04YesYes254
15R:R:Y119 R:R:Y313 14.655123.83YesYes044
16R:R:E209 R:R:S211 45.29347.19NoNo034
17R:R:E209 R:R:R202 43.641611.63NoYes032
18R:R:D206 R:R:R202 14.90839.53NoYes032
19R:R:M112 R:R:Y66 39.71113.59YesYes276
20R:R:M112 R:R:V69 11.21036.09YesNo077
21R:R:M142 R:R:W287 41.21776.98NoYes178
22R:R:N322 R:R:W287 44.49249.04YesYes198
23R:R:N322 R:R:N326 51.50249.54YesYes199
24R:R:D105 R:R:N326 40.221612.12YesYes199
25R:R:F143 R:R:V230 29.00315.24YesNo065
26R:R:F143 R:R:S186 25.7992.64YesNo068
27R:R:S186 R:R:T144 26.64987.99NoYes087
28R:R:T144 R:R:W183 22.499412.13YesYes479
29R:R:L103 R:R:W183 79.56346.83NoYes069
30R:R:L103 R:R:M81 76.33854.24NoNo067
31R:R:F99 R:R:M81 74.52893.73NoNo057
32R:R:F99 R:R:K89 72.71119.93NoNo055
33R:R:I84 R:R:K89 65.35652.91NoNo075
34R:R:I84 R:R:N95 61.62954.25NoYes077
35R:R:N95 R:R:Y87 20.87242.33YesNo075
36R:R:R339 R:R:Y87 14.69665.14NoNo055
37R:R:N95 R:R:T94 38.49095.85YesYes678
38R:R:R170 R:R:T94 30.7963.88NoYes068
39R:R:D155 R:R:R170 26.965211.91NoNo086
40R:R:D155 R:R:Y97 24.92749.2NoNo087
41R:R:N100 R:R:W183 80.6015.65NoYes499
42R:R:L101 R:R:N326 32.23622.75YesYes199
43R:R:L101 R:R:T148 86.62328.84YesNo097
44R:R:L101 R:R:M152 24.86934.24YesNo098
45R:R:N326 R:R:Y330 1003.49YesYes199
46R:R:M152 R:R:Y330 24.48333.59NoYes089
47R:R:D138 R:R:Y320 10.467310.34NoNo066
48R:R:V108 R:R:Y320 37.69825.05NoNo076
49R:R:S323 R:R:V108 38.04278.08NoNo087
50R:R:M112 R:R:Y320 38.17963.59YesNo076
51R:R:D138 R:R:T111 11.08575.78NoNo067
52R:R:K200 R:R:R202 22.64052.48NoYes022
53R:R:K200 R:R:Q213 20.81434.07NoNo024
54R:R:G198 R:R:Q213 18.96324.93NoNo044
55R:R:D128 R:R:G198 13.36021.68NoNo024
56R:R:D128 R:R:T199 11.47595.78NoNo024
57R:R:I178 R:R:Y97 16.74282.42NoNo067
58R:R:H291 R:R:W287 14.28169.52NoYes188
59R:R:F235 R:R:V239 11.53817.87YesNo086
60R:R:I243 R:R:V239 16.84243.07NoNo056
61R:R:I243 R:R:V280 13.70474.61NoNo058
62R:R:I242 R:R:V280 14.58453.07NoNo088
63R:R:R156 R:R:Y330 70.56538.23NoYes099
64R:R:R156 R:R:Y246 69.2879.26NoYes098
65R:R:S153 R:R:Y246 54.68585.09NoYes098
66R:R:V279 R:R:Y330 70.71058.83NoYes089
67R:R:V279 R:R:Y246 69.3165.05NoYes088
68R:R:C245 R:R:S153 53.90971.72YesNo079
69R:R:C245 R:R:Y157 42.41726.72YesYes077
70R:R:I158 R:R:Y157 11.76233.63NoYes057
71R:R:H162 R:R:Y157 15.63465.44YesYes867
72R:R:V276 R:R:Y246 89.516112.62NoYes088
73R:R:I250 R:R:V276 83.16594.61NoNo058
74R:R:I250 R:R:M249 76.64562.92NoNo058
75R:R:M249 R:R:V160 73.3716.09NoNo088
76R:R:I177 R:R:I178 12.61311.47NoNo036
77R:R:I177 R:R:L173 10.52964.28NoNo034
78R:R:F214 R:R:P215 13.36021.44NoYes065
79R:R:I290 R:R:I316 17.22422.94NoYes065
80R:R:C315 R:R:I290 17.39854.91NoNo076
81R:R:C315 R:R:P289 17.06237.53NoNo079
82R:R:P289 R:R:T288 17.04163.5NoYes095
83R:R:L253 R:R:V160 70.22911.49YesNo088
84R:R:L253 R:R:V256 54.17122.98YesNo586
85R:R:L258 R:R:V256 51.03351.49NoNo056
86R:R:K265 R:R:L258 47.68821.41NoNo045
87R:R:K265 R:R:S262 44.33479.18NoNo041
88R:R:G261 R:R:S262 10.35531.86NoNo031
89R:R:E264 R:R:S262 30.83761.44NoNo031
90R:R:E264 R:R:R267 24.03922.33NoYes034
91R:R:R267 R:R:R270 10.35534.26YesNo045
92R:R:F235 R:R:T288 11.34315.19YesYes085
93R:R:D105 R:R:S323 37.93897.36YesNo198
94R:R:N100 R:R:T148 84.92994.39NoNo097
95R:R:I242 R:R:S153 15.83387.74NoNo089
96R:R:Q115 R:R:Y66 24.9735.64YesYes276
97R:R:L101 R:R:L149 24.54552.77YesNo198
98R:R:W183 R:R:Y140 14.687.72YesYes495
99R:R:L149 R:R:Y330 24.30073.52NoYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Y1 R:R:Y139 10.92 0 Yes No 0 5 0 1
L:L:Y1 R:R:M142 8.38 0 Yes No 0 7 0 1
L:L:Y1 R:R:V230 6.31 0 Yes No 0 5 0 1
L:L:Y1 R:R:I294 7.25 0 Yes No 0 5 0 1
L:L:G2 R:R:I316 7.05 0 No Yes 0 5 0 1
L:L:F4 R:R:Q115 10.54 0 No Yes 0 7 0 1
L:L:F4 R:R:L135 6.09 0 No No 0 4 0 1
L:L:F4 R:R:S211 2.64 0 No No 0 4 0 1
L:L:L5 R:R:K227 7.05 0 No No 0 4 0 1
L:L:R6 R:R:F214 4.28 0 No No 0 6 0 1
L:L:R6 R:R:Y219 11.32 0 No No 0 1 0 1
L:L:R6 R:R:D223 10.72 0 No No 0 4 0 1
L:L:R7 R:R:L309 12.15 0 No No 0 4 0 1
L:L:R7 R:R:Y312 16.46 0 No Yes 0 4 0 1
L:L:I8 R:R:H304 9.28 0 No No 0 1 0 1
L:L:R9 R:R:N122 14.46 0 No No 0 5 0 1
L:L:R9 R:R:D206 4.76 0 No No 0 3 0 1
R:R:Q115 R:R:Y66 5.64 2 Yes Yes 7 6 1 2
R:R:Y313 R:R:Y66 5.96 2 Yes Yes 4 6 2 2
R:R:I316 R:R:Y66 6.04 2 Yes Yes 5 6 1 2
R:R:Q115 R:R:Y313 5.64 2 Yes Yes 7 4 1 2
R:R:I316 R:R:Q115 6.86 2 Yes Yes 5 7 1 1
R:R:L309 R:R:Y119 4.69 0 No Yes 4 4 1 2
R:R:Y119 R:R:Y313 23.83 0 Yes Yes 4 4 2 2
R:R:L135 R:R:L212 5.54 0 No No 4 4 1 2
R:R:D138 R:R:Y139 4.6 0 No No 6 5 2 1
R:R:I146 R:R:M142 4.37 1 Yes No 7 7 2 1
R:R:M142 R:R:W287 6.98 1 No Yes 7 8 1 2
R:R:F143 R:R:V230 5.24 0 Yes No 6 5 2 1
R:R:I146 R:R:W287 5.87 1 Yes Yes 7 8 2 2
R:R:D206 R:R:R202 9.53 0 No Yes 3 2 1 2
R:R:E209 R:R:R202 11.63 0 No Yes 3 2 2 2
R:R:D206 R:R:V207 2.92 0 No No 3 3 1 2
R:R:E209 R:R:S211 7.19 0 No No 3 4 2 1
R:R:S220 R:R:Y219 3.82 0 No No 2 1 2 1
R:R:I294 R:R:K227 5.82 0 No No 5 4 1 1
R:R:I290 R:R:I294 5.89 0 No No 6 5 2 1
R:R:I290 R:R:I316 2.94 0 No Yes 6 5 2 1
R:R:E297 R:R:F293 5.83 2 No Yes 5 5 2 2
R:R:F293 R:R:Y312 13.41 2 Yes Yes 5 4 2 1
R:R:E297 R:R:Y312 5.61 2 No Yes 5 4 2 1
R:R:Y312 R:R:Y313 8.94 2 Yes Yes 4 4 1 2
R:R:I316 R:R:Y312 4.84 2 Yes Yes 5 4 1 1
R:R:I316 R:R:Y313 6.04 2 Yes Yes 5 4 1 2
R:R:M226 R:R:Y139 2.39 0 No No 5 5 2 1
R:R:A234 R:R:V230 1.7 0 No No 6 5 2 1
R:R:F214 R:R:P215 1.44 0 No Yes 6 5 1 2
R:R:D223 R:R:L212 1.36 0 No No 4 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7Y1F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.64
Number of Linked Nodes 273
Number of Links 308
Number of Hubs 37
Number of Links mediated by Hubs 140
Number of Communities 9
Number of Nodes involved in Communities 55
Number of Links involved in Communities 72
Path Summary
Number Of Nodes in MetaPath 100
Number Of Links MetaPath 99
Number of Shortest Paths 67437
Length Of Smallest Path 3
Average Path Length 16.63
Length of Longest Path 37
Minimum Path Strength 1.38
Average Path Strength 5.75702
Maximum Path Strength 16.385
Minimum Path Correlation 0.7
Average Path Correlation 0.925521
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 44.5034
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.7499
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41145
Sequence
>7Y1F_nogp_Chain_R
PAIPVIITA VYSVVFVVG LVGNSLVMF VIIRYTKMK TATNIYIFN 
LALADALVT TTMPFQSTV YLMNSWPFG DVLCKIVLS IDYYNMFTS 
IFTLTMMSV DRYIAVCHP VKALDFRTP LKAKIINIC IWLLSSSVG 
ISAIVLGGT KVREDVDVI ECSLQFPDD DYSWWDLFM KICVFIFAF 
VIPVLIIIV CYTLMILRL KSVRLLSGS REKDRNLRR ITRLVLVVV 
AVFVVCWTP IHIFILVEA LGSTSHSTA ALSSYYFCI ALGYTNSSL 
NPILYAFLD ENFKR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6B73APeptideOpioidκHomo sapiensMP1104--3.12018-01-17doi.org/10.1016/j.cell.2017.12.011
8F7WAPeptideOpioidκHomo sapiensDynorphin-Gi1/β1/γ23.192022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7W (No Gprot) APeptideOpioidκHomo sapiensDynorphin-3.192022-12-14doi.org/10.1016/j.cell.2022.12.026
4DJHAPeptideOpioidκHomo sapiensJDTic--2.92012-03-21doi.org/10.1038/nature10939
6VI4APeptideOpioidκHomo sapiensJDTic--3.32020-03-18doi.org/10.1038/s41467-020-14889-7
7YITAPeptideOpioidκHomo sapiensNalfurafine--3.32023-04-12doi.org/10.1038/s41467-023-37041-7
8FEGAPeptideOpioidκHomo sapiens(DNCP)-β-Naloxamine-Gi1/β1/γ22.542023-12-06doi.org/10.1038/s41467-023-43718-w
8FEG (No Gprot) APeptideOpioidκHomo sapiens(DNCP)-β-Naloxamine-2.542023-12-06doi.org/10.1038/s41467-023-43718-w
8DZPAPeptideOpioidκHomo sapiensmomSalB-Gi1/β1/γ22.712023-05-03doi.org/10.1038/s41586-023-06030-7
8DZP (No Gprot) APeptideOpioidκHomo sapiensmomSalB-2.712023-05-03doi.org/10.1038/s41586-023-06030-7
8DZQAPeptideOpioidκHomo sapiensmomSalB-Go/β1/γ22.822023-05-03doi.org/10.1038/s41586-023-06030-7
8DZQ (No Gprot) APeptideOpioidκHomo sapiensmomSalB-2.822023-05-03doi.org/10.1038/s41586-023-06030-7
8DZRAPeptideOpioidκHomo sapiensGR89,696-chim(NtGi2-Gt3)/β1/γ22.612023-05-03doi.org/10.1038/s41586-023-06030-7
8DZR (No Gprot) APeptideOpioidκHomo sapiensGR89,696-2.612023-05-03doi.org/10.1038/s41586-023-06030-7
8DZSAPeptideOpioidκHomo sapiensGR89,696-chim(NtGi2-Gz)/β1/γ22.652023-05-03doi.org/10.1038/s41586-023-06030-7
8DZS (No Gprot) APeptideOpioidκHomo sapiensGR89,696-2.652023-05-03doi.org/10.1038/s41586-023-06030-7
7Y1FAPeptideOpioidκHomo sapiensDynorphin-Gi1/β1/γ23.32023-05-24doi.org/10.1093/procel/pwac033
7Y1F (No Gprot) APeptideOpioidκHomo sapiensDynorphin-3.32023-05-24doi.org/10.1093/procel/pwac033
9MQKAPeptideOpioidκHomo sapiensIsoquinuclidine--3.182025-02-12doi.org/10.1101/2025.01.09.632033
9MQLAPeptideOpioidκHomo sapiensIsoquinuclidine--2.962025-02-12doi.org/10.1101/2025.01.09.632033
8VVEAPeptideOpioidκHomo sapiensnorBNI-Gi1/β1/γ23.32025-01-15doi.org/10.1038/s41589-024-01812-0
8VVE (No Gprot) APeptideOpioidκHomo sapiensnorBNI-3.32025-01-15doi.org/10.1038/s41589-024-01812-0
8VVFAPeptideOpioidκHomo sapiensJDTic-Gi1/β1/γ232025-01-15doi.org/10.1038/s41589-024-01812-0
8VVF (No Gprot) APeptideOpioidκHomo sapiensJDTic-32025-01-15doi.org/10.1038/s41589-024-01812-0
8VVGAPeptideOpioidκHomo sapiensGB18-Gi1/β1/γ23.32025-01-15doi.org/10.1038/s41589-024-01812-0
8VVG (No Gprot) APeptideOpioidκHomo sapiensGB18-3.32025-01-15doi.org/10.1038/s41589-024-01812-0
9D61APeptideOpioidκHomo sapiensJDTic-Gi1/β1/γ23.582025-01-15doi.org/10.1038/s41589-024-01812-0
9D61 (No Gprot) APeptideOpioidκHomo sapiensJDTic-3.582025-01-15doi.org/10.1038/s41589-024-01812-0




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y1F_nogp.zip



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