psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I58	R:R:P59	5.08	Yes	No	0	4	4
2	R:R:I62	R:R:Y119	8.46	No	No	0	5	4
3	R:R:M112	R:R:Y66	3.59	Yes	Yes	0	7	6
4	R:R:Y313	R:R:Y66	7.94	Yes	Yes	0	4	6
5	R:R:I316	R:R:Y66	7.25	No	Yes	0	5	6
6	R:R:A317	R:R:Y66	4	No	Yes	0	5	6
7	R:R:M112	R:R:V69	6.09	Yes	No	0	7	7
8	R:R:T321	R:R:V69	6.35	No	No	0	5	7
9	R:R:F70	R:R:L74	3.65	Yes	No	0	7	6
10	R:R:F70	R:R:T109	5.19	Yes	No	0	7	6
11	R:R:F70	R:R:M112	4.98	Yes	Yes	0	7	7
12	R:R:F70	R:R:P113	8.67	Yes	No	0	7	8
13	R:R:G73	R:R:V72	3.68	No	No	0	8	5
14	R:R:G73	R:R:T109	3.64	No	No	0	8	6
15	R:R:G73	R:R:S324	3.71	No	No	0	8	7
16	R:R:D105	R:R:N77	6.73	Yes	No	0	9	9
17	R:R:A106	R:R:N77	4.69	No	No	0	8	9
18	R:R:N77	R:R:P327	8.15	No	No	0	9	9
19	R:R:F332	R:R:L79	3.65	No	No	0	6	6
20	R:R:F332	R:R:V80	3.93	No	No	0	6	9
21	R:R:F99	R:R:M81	8.71	Yes	No	0	5	7
22	R:R:L103	R:R:M81	5.65	No	No	0	6	7
23	R:R:F337	R:R:V83	5.24	No	No	0	8	8
24	R:R:F99	R:R:I84	6.28	Yes	No	0	5	7
25	R:R:F337	R:R:I84	3.77	No	No	0	8	7
26	R:R:N95	R:R:T88	4.39	No	No	0	7	6
27	R:R:C340	R:R:T88	10.14	No	No	0	6	6
28	R:R:K89	R:R:K91	14.37	No	No	0	5	7
29	R:R:F99	R:R:M90	4.98	Yes	No	0	5	7
30	R:R:T92	R:R:T94	4.71	No	No	0	7	8
31	R:R:N95	R:R:T92	8.77	No	No	0	7	7
32	R:R:I96	R:R:K176	5.82	No	No	0	5	4
33	R:R:I96	R:R:N179	4.25	No	No	0	5	7
34	R:R:M152	R:R:Y97	5.99	No	Yes	0	8	7
35	R:R:D155	R:R:Y97	5.75	No	Yes	0	8	7
36	R:R:A175	R:R:Y97	4	No	Yes	0	7	7
37	R:R:I178	R:R:Y97	7.25	No	Yes	0	6	7
38	R:R:N179	R:R:Y97	6.98	No	Yes	0	7	7
39	R:R:D334	R:R:I98	4.2	No	No	0	8	8
40	R:R:N100	R:R:N179	17.71	No	No	0	9	7
41	R:R:N100	R:R:W183	6.78	No	Yes	0	9	9
42	R:R:D105	R:R:L101	9.5	Yes	Yes	0	9	9
43	R:R:L101	R:R:T148	7.37	Yes	No	0	9	7
44	R:R:L101	R:R:L149	5.54	Yes	No	5	9	8
45	R:R:L101	R:R:Y330	4.69	Yes	Yes	5	9	9
46	R:R:L103	R:R:L107	4.15	No	No	0	6	6
47	R:R:L103	R:R:W183	4.56	No	Yes	0	6	9
48	R:R:D105	R:R:S145	5.89	Yes	No	0	9	9
49	R:R:D105	R:R:S323	7.36	Yes	No	0	9	8
50	R:R:D105	R:R:N326	10.77	Yes	No	0	9	9
51	R:R:L107	R:R:N141	13.73	No	No	1	6	8
52	R:R:L107	W:W:?1	4.64	No	Yes	1	6	0
53	R:R:S323	R:R:V108	4.85	No	No	0	8	7
54	R:R:D138	R:R:T111	7.23	No	No	6	6	7
55	R:R:T111	R:R:Y320	3.75	No	Yes	6	7	6
56	R:R:M112	R:R:Y320	7.18	Yes	Yes	0	7	6
57	R:R:F114	R:R:W124	5.01	No	Yes	2	5	8
58	R:R:F114	R:R:F126	7.5	No	Yes	2	5	7
59	R:R:F114	R:R:V134	10.49	No	No	0	5	6
60	R:R:Q115	R:R:Y320	12.4	No	Yes	0	7	6
61	L:L:G3	R:R:Q115	6.58	No	No	0	0	7
62	L:L:F4	R:R:Q115	11.71	No	No	0	0	7
63	R:R:Y119	R:R:Y313	21.84	No	Yes	0	4	4
64	L:L:R9	R:R:N122	13.26	No	No	0	0	5
65	R:R:I208	R:R:S123	4.64	No	No	0	4	4
66	R:R:F126	R:R:W124	18.04	Yes	Yes	2	7	8
67	R:R:C131	R:R:W124	7.84	No	Yes	2	9	8
68	R:R:T199	R:R:W124	7.28	Yes	Yes	2	4	8
69	R:R:C210	R:R:W124	11.75	No	Yes	2	9	8
70	R:R:F126	R:R:P125	8.67	Yes	No	0	7	1
71	R:R:F126	R:R:L130	7.31	Yes	No	0	7	5
72	R:R:D128	R:R:K132	6.91	No	No	0	2	6
73	R:R:D128	R:R:T199	7.23	No	Yes	0	2	4
74	R:R:C131	R:R:T199	5.07	No	Yes	2	9	4
75	R:R:C131	R:R:C210	7.28	No	No	2	9	9
76	L:L:F4	R:R:I135	11.3	No	No	0	0	4
77	R:R:I194	R:R:S136	6.19	No	No	0	4	5
78	R:R:I137	R:R:N141	5.66	No	No	1	5	8
79	R:R:I137	W:W:?1	8.37	No	Yes	1	5	0
80	R:R:D138	R:R:Y320	4.6	No	Yes	6	6	6
81	L:L:F4	R:R:D138	7.17	No	No	0	0	6
82	R:R:V189	R:R:Y139	3.79	No	No	0	5	5
83	L:L:Y1	R:R:Y139	5.96	Yes	No	0	0	5
84	R:R:T144	R:R:Y140	4.99	Yes	Yes	1	7	5
85	R:R:W183	R:R:Y140	12.54	Yes	Yes	1	9	5
86	R:R:S186	R:R:Y140	5.09	No	Yes	1	8	5
87	R:R:Y140	W:W:?1	40.25	Yes	Yes	1	5	0
88	R:R:N141	W:W:?1	6.9	No	Yes	1	8	0
89	R:R:M142	R:R:W287	5.82	No	Yes	0	7	8
90	L:L:Y1	R:R:M142	7.18	Yes	No	0	0	7
91	R:R:F143	R:R:F147	5.36	No	No	0	6	6
92	R:R:F143	R:R:V189	7.87	No	No	0	6	5
93	R:R:F143	R:R:V230	5.24	No	Yes	0	6	5
94	R:R:T144	R:R:W183	9.7	Yes	Yes	1	7	9
95	R:R:S186	R:R:T144	4.8	No	Yes	1	8	7
96	R:R:F147	R:R:I182	5.02	No	No	0	6	7
97	R:R:F147	R:R:L185	3.65	No	No	0	6	4
98	R:R:L149	R:R:N326	9.61	No	No	0	8	9
99	R:R:L149	R:R:Y330	8.21	No	Yes	5	8	9
100	R:R:I241	R:R:T150	4.56	No	No	0	6	7
101	R:R:I178	R:R:M151	4.37	No	No	0	6	6
102	R:R:I182	R:R:M151	4.37	No	No	0	7	6
103	R:R:M152	R:R:Y330	7.18	No	Yes	0	8	9
104	R:R:I242	R:R:S153	7.74	No	No	0	8	9
105	R:R:S153	R:R:Y246	13.99	No	Yes	0	9	8
106	R:R:D155	R:R:R170	14.29	No	No	0	8	6
107	R:R:R156	R:R:Y246	7.2	No	Yes	0	9	8
108	R:R:R156	R:R:Y330	5.14	No	Yes	0	9	9
109	R:R:C161	R:R:Y157	6.72	No	Yes	0	7	7
110	R:R:H162	R:R:Y157	7.62	No	Yes	0	6	7
111	R:R:C245	R:R:Y157	8.06	No	Yes	0	7	7
112	R:R:L248	R:R:Y157	8.21	No	Yes	0	4	7
113	R:R:F169	R:R:I158	10.05	No	No	0	4	5
114	R:R:A159	R:R:R170	5.53	No	No	0	8	6
115	R:R:M249	R:R:V160	9.13	No	No	0	8	8
116	R:R:F169	R:R:K174	7.44	No	No	0	4	5
117	R:R:F169	R:R:I178	3.77	No	No	0	4	6
118	R:R:P172	R:R:T171	5.25	No	No	0	2	7
119	R:R:I177	R:R:L173	4.28	No	No	0	3	4
120	R:R:W183	W:W:?1	6.68	Yes	Yes	1	9	0
121	R:R:S187	W:W:?1	5.03	No	Yes	0	4	0
122	R:R:G190	W:W:?1	4.3	No	Yes	0	6	0
123	R:R:I191	W:W:?1	5.98	No	Yes	0	4	0
124	R:R:I194	W:W:?1	3.59	No	Yes	0	4	0
125	R:R:F214	R:R:L196	4.87	Yes	No	0	6	4
126	R:R:G198	R:R:Q213	4.93	No	No	0	4	4
127	R:R:E209	R:R:K200	5.4	No	Yes	7	3	2
128	R:R:K200	R:R:Q213	9.49	Yes	No	0	2	4
129	L:L:R6	R:R:K200	12.38	Yes	Yes	7	0	2
130	R:R:I208	R:R:V201	4.61	No	No	0	4	2
131	R:R:D204	R:R:R202	14.29	No	No	0	2	2
132	R:R:D204	R:R:V205	5.84	No	No	0	2	1
133	R:R:V205	R:R:V207	6.41	No	No	0	1	3
134	L:L:R6	R:R:E209	8.14	Yes	No	7	0	3
135	L:L:R6	R:R:S211	3.95	Yes	No	0	0	4
136	R:R:F214	R:R:L212	3.65	Yes	No	0	6	4
137	R:R:F214	R:R:Y219	7.22	Yes	No	0	6	1
138	R:R:F214	R:R:W222	5.01	Yes	No	0	6	7
139	R:R:D223	R:R:F214	3.58	No	Yes	0	4	6
140	R:R:D218	R:R:W222	8.93	No	No	0	4	7
141	L:L:R6	R:R:Y219	26.75	Yes	No	0	0	1
142	R:R:W221	R:R:W222	14.99	No	No	0	1	7
143	R:R:D223	R:R:K227	12.44	No	Yes	0	4	4
144	R:R:M226	R:R:V230	4.56	No	Yes	0	5	5
145	R:R:I294	R:R:K227	4.36	Yes	Yes	8	5	4
146	R:R:A298	R:R:K227	4.82	No	Yes	0	4	4
147	L:L:L5	R:R:K227	7.05	No	Yes	8	0	4
148	L:L:Y1	R:R:V230	8.83	Yes	Yes	0	0	5
149	R:R:F231	R:R:I232	3.77	Yes	No	0	5	5
150	R:R:F231	R:R:F235	5.36	Yes	Yes	3	5	8
151	R:R:F231	R:R:V236	3.93	Yes	No	0	5	4
152	R:R:F231	R:R:H291	6.79	Yes	No	3	5	8
153	R:R:F231	R:R:L295	12.18	Yes	No	0	5	5
154	R:R:F233	R:R:I232	5.02	No	No	0	4	5
155	R:R:F235	R:R:V239	7.87	Yes	No	0	8	6
156	R:R:F235	R:R:T288	7.78	Yes	Yes	0	8	5
157	R:R:F235	R:R:H291	4.53	Yes	No	3	8	8
158	R:R:M249	R:R:Y246	3.59	No	Yes	0	8	8
159	R:R:V276	R:R:Y246	7.57	No	Yes	0	8	8
160	R:R:I250	R:R:T273	7.6	No	No	0	5	6
161	R:R:L253	R:R:L259	5.54	No	Yes	0	8	3
162	R:R:K254	R:R:L269	5.64	No	Yes	0	4	6
163	R:R:L259	R:R:V256	4.47	Yes	No	0	3	6
164	R:R:L259	R:R:L269	6.92	Yes	Yes	0	3	6
165	R:R:K265	R:R:N268	5.6	No	No	0	4	5
166	R:R:N268	R:R:R271	6.03	No	No	0	5	7
167	R:R:R270	R:R:R274	13.86	No	No	0	5	6
168	R:R:E335	R:R:R271	10.47	No	No	0	4	7
169	R:R:V279	R:R:Y330	8.83	No	Yes	0	8	9
170	R:R:L329	R:R:V282	4.47	No	No	0	8	7
171	R:R:F283	R:R:W287	11.02	No	Yes	3	9	8
172	R:R:F283	R:R:N322	7.25	No	Yes	3	9	9
173	R:R:T288	R:R:V284	4.76	Yes	No	0	5	6
174	R:R:C286	R:R:N322	6.3	No	Yes	0	8	9
175	R:R:H291	R:R:W287	8.46	No	Yes	3	8	8
176	R:R:N322	R:R:W287	13.56	Yes	Yes	3	9	8
177	R:R:I290	R:R:I294	5.89	No	Yes	0	6	5
178	R:R:E297	R:R:F293	10.49	No	No	0	5	5
179	R:R:F293	R:R:S311	5.28	No	No	0	5	4
180	R:R:F293	R:R:Y312	10.32	No	Yes	0	5	4
181	R:R:I294	R:R:Y312	4.84	Yes	Yes	0	5	4
182	L:L:Y1	R:R:I294	3.63	Yes	Yes	0	0	5
183	L:L:L5	R:R:I294	4.28	No	Yes	8	0	5
184	L:L:R7	R:R:E297	10.47	No	No	0	0	5
185	L:L:I8	R:R:H304	7.95	No	No	0	0	1
186	R:R:L309	R:R:Y313	4.69	No	Yes	4	4	4
187	L:L:R7	R:R:L309	6.07	No	No	0	0	4
188	L:L:R9	R:R:L309	13.36	No	No	4	0	4
189	R:R:I316	R:R:Y312	6.04	No	Yes	0	5	4
190	L:L:R7	R:R:Y312	5.14	No	Yes	0	0	4
191	L:L:R9	R:R:Y313	4.12	No	Yes	4	0	4
192	R:R:F314	R:R:L318	9.74	No	No	0	5	8
193	R:R:N322	R:R:N326	8.17	Yes	No	0	9	9
194	R:R:A331	R:R:F337	6.93	No	No	0	7	8
195	R:R:E335	R:R:K338	6.75	No	No	0	4	8
196	R:R:L120	R:R:Y119	3.52	No	No	0	4	4
197	R:R:P238	R:R:T150	3.5	No	No	0	9	7
198	R:R:P289	R:R:T288	3.5	No	Yes	0	9	5
199	R:R:C245	R:R:S153	3.44	No	No	0	7	9
200	R:R:A193	R:R:S136	3.42	No	No	0	5	5
201	R:R:G300	R:R:L299	3.42	No	No	0	2	4
202	L:L:G2	L:L:L5	3.42	No	No	0	0	0
203	R:R:A102	R:R:V80	3.39	No	No	0	8	9
204	R:R:A331	R:R:V80	3.39	No	No	0	7	9
205	R:R:I146	R:R:P238	3.39	No	No	0	7	9
206	R:R:I237	R:R:P238	3.39	No	No	0	5	9
207	R:R:A104	R:R:T144	3.36	No	Yes	0	8	7
208	R:R:D128	R:R:G198	3.35	No	No	0	2	4
209	R:R:C315	R:R:I290	3.27	No	No	0	7	6
210	R:R:A57	R:R:I58	3.25	No	Yes	0	4	4
211	R:R:S123	R:R:V207	3.23	No	No	0	4	3
212	R:R:S188	R:R:V189	3.23	No	No	0	4	5
213	R:R:D218	R:R:P215	3.22	No	No	0	4	5
214	R:R:S116	R:R:T63	3.2	No	No	0	6	5
215	R:R:C340	R:R:N336	3.15	No	No	0	6	6
216	R:R:I58	R:R:S310	3.1	Yes	No	0	4	2
217	R:R:I62	R:R:S310	3.1	No	No	0	5	2
218	R:R:F82	R:R:Y87	3.09	No	No	0	4	5
219	R:R:I158	R:R:V154	3.07	No	No	0	5	6
220	R:R:I243	R:R:V280	3.07	No	No	0	5	8
221	R:R:I98	R:R:T94	3.04	No	No	0	8	8
222	R:R:I242	R:R:T150	3.04	No	No	0	8	7
223	R:R:I292	R:R:T288	3.04	No	Yes	0	5	5
224	R:R:L74	R:R:S78	3	No	No	0	6	4
225	R:R:L253	R:R:V160	2.98	No	No	0	8	8
226	R:R:L248	R:R:V244	2.98	No	No	0	4	4
227	R:R:L329	R:R:V279	2.98	No	No	0	8	8
228	R:R:L251	R:R:T247	2.95	No	No	0	4	4
229	R:R:L269	R:R:T273	2.95	Yes	No	0	6	6
230	R:R:L277	R:R:T273	2.95	No	No	0	4	6
231	R:R:L325	R:R:T321	2.95	No	No	0	6	5
232	R:R:I58	R:R:I61	2.94	Yes	No	0	4	5
233	R:R:I133	R:R:L130	2.85	No	No	0	5	5
234	R:R:I180	R:R:L184	2.85	No	No	0	4	4
235	R:R:I228	R:R:L224	2.85	No	No	0	5	3
236	R:R:C161	R:R:R252	2.79	No	No	0	7	5
237	R:R:C229	R:R:F233	2.79	No	No	0	3	4
238	R:R:A166	R:R:R170	2.77	No	No	0	5	6
239	R:R:D216	R:R:K200	2.77	No	Yes	0	2	2
240	R:R:L275	R:R:L333	2.77	No	No	0	8	7
241	R:R:D266	R:R:L269	2.71	No	Yes	0	3	6
242	R:R:A93	R:R:Y97	2.67	No	Yes	0	6	7
243	R:R:V280	R:R:Y246	2.52	No	Yes	0	8	8
244	R:R:F99	R:R:I85	2.51	Yes	No	0	5	3
245	R:R:V118	R:R:W124	2.45	No	Yes	0	5	8
246	R:R:E264	R:R:R267	2.33	No	No	0	3	4
247	R:R:G197	R:R:G198	2.11	No	No	0	4	4
248	R:R:G76	R:R:V75	1.84	No	No	0	7	4
249	R:R:P125	R:R:T117	1.75	No	No	0	1	4
250	R:R:A308	R:R:S305	1.71	No	No	0	3	3
251	R:R:G319	R:R:L318	1.71	No	No	0	7	8
252	R:R:A317	R:R:V65	1.7	No	No	0	5	5
253	R:R:A234	R:R:V230	1.7	No	Yes	0	6	5
254	R:R:I96	R:R:P172	1.69	No	No	0	5	2
255	R:R:C181	R:R:I177	1.64	No	No	0	4	3
256	R:R:L318	R:R:P289	1.64	No	No	0	8	9
257	R:R:S303	R:R:S305	1.63	No	No	0	1	3
258	R:R:A331	R:R:I98	1.62	No	No	0	7	8
259	R:R:S67	R:R:T63	1.6	No	No	0	4	5
260	R:R:V68	R:R:V72	1.6	No	No	0	5	5
261	R:R:V71	R:R:V75	1.6	No	No	0	5	4
262	R:R:V278	R:R:V282	1.6	No	No	0	5	7
263	R:R:A298	R:R:L224	1.58	No	No	0	4	3
264	R:R:I133	R:R:V129	1.54	No	No	0	5	1
265	R:R:I191	R:R:V195	1.54	No	No	0	4	4
266	R:R:I292	R:R:V296	1.54	No	No	0	5	4
267	R:R:H162	R:R:P163	1.53	No	No	0	6	8
268	R:R:I208	R:R:T199	1.52	No	Yes	0	4	4
269	R:R:I243	R:R:T247	1.52	No	No	0	5	4
270	L:L:I8	R:R:T302	1.52	No	No	0	0	1
271	R:R:M121	R:R:T117	1.51	No	No	0	4	4
272	R:R:F126	R:R:G127	1.51	Yes	No	0	7	7
273	R:R:L120	R:R:S116	1.5	No	No	0	4	6
274	R:R:L240	R:R:V236	1.49	No	No	0	3	4
275	R:R:L258	R:R:V256	1.49	No	No	0	5	6
276	R:R:L275	R:R:V279	1.49	No	No	0	8	8
277	R:R:L173	R:R:T171	1.47	No	No	0	4	7
278	R:R:I272	R:R:L253	1.43	No	No	0	7	8
279	R:R:I328	R:R:L325	1.43	No	No	0	7	6
280	R:R:K265	R:R:L259	1.41	No	Yes	0	4	3
281	R:R:D217	R:R:D218	1.33	No	No	0	1	4
282	R:R:R252	R:R:S255	1.32	No	No	0	5	4
283	R:R:F70	R:R:V71	1.31	Yes	No	0	7	5
284	R:R:H162	R:R:K165	1.31	No	No	0	6	4
285	R:R:V83	R:R:Y87	1.26	No	No	0	8	5
286	R:R:R339	R:R:R342	1.07	No	No	0	5	5
287	R:R:F341	R:R:R342	1.07	No	No	0	6	5
288	R:R:R86	R:R:Y87	1.03	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I58	3.5925	4	0	4
2	R:R:Y66	5.695	4	0	6
3	R:R:F70	4.76	5	0	7
4	R:R:Y97	5.44	6	0	7
5	R:R:F99	5.62	4	0	5
6	R:R:L101	6.775	4	5	9
7	R:R:D105	8.05	5	0	9
8	R:R:M112	5.46	4	0	7
9	R:R:W124	8.72833	6	2	8
10	R:R:F126	8.606	5	2	7
11	R:R:Y140	15.7175	4	1	5
12	R:R:T144	5.7125	4	1	7
13	R:R:Y157	7.6525	4	0	7
14	R:R:W183	8.052	5	1	9
15	R:R:T199	5.275	4	2	4
16	R:R:K200	7.51	4	7	2
17	R:R:F214	4.866	5	0	6
18	R:R:K227	7.1675	4	8	4
19	R:R:V230	5.0825	4	0	5
20	R:R:F231	6.406	5	3	5
21	R:R:F235	6.385	4	3	8
22	R:R:Y246	6.974	5	0	8
23	R:R:L259	4.585	4	0	3
24	R:R:L269	4.555	4	0	6
25	R:R:W287	9.715	4	3	8
26	R:R:T288	4.77	4	0	5
27	R:R:I294	4.6	5	8	5
28	R:R:Y312	6.585	4	0	4
29	R:R:Y313	9.6475	4	4	4
30	R:R:Y320	6.9825	4	6	6
31	R:R:N322	8.82	4	3	9
32	R:R:Y330	6.81	5	5	9
33	L:L:Y1	6.4	4	0	0
34	L:L:R6	12.805	4	7	0
35	W:W:?1	9.52667	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I58	R:R:S310	10.3878	3.1	Yes	No	0	4	2
2	R:R:I62	R:R:S310	12.9589	3.1	No	No	0	5	2
3	R:R:I62	R:R:Y119	15.5191	8.46	No	No	0	5	4
4	R:R:Y119	R:R:Y313	27.9224	21.84	No	Yes	0	4	4
5	R:R:Y313	R:R:Y66	16.7012	7.94	Yes	Yes	0	4	6
6	R:R:M112	R:R:Y66	33.5385	3.59	Yes	Yes	0	7	6
7	R:R:I316	R:R:Y66	48.4748	7.25	No	Yes	0	5	6
8	R:R:F70	R:R:M112	16.5977	4.98	Yes	Yes	0	7	7
9	R:R:N322	R:R:N326	57.2012	8.17	Yes	No	0	9	9
10	R:R:N322	R:R:W287	56.7164	13.56	Yes	Yes	3	9	8
11	R:R:M142	R:R:W287	57.4137	5.82	No	Yes	0	7	8
12	L:L:Y1	R:R:M142	57.3537	7.18	Yes	No	0	0	7
13	L:L:Y1	R:R:I294	100	3.63	Yes	Yes	0	0	5
14	R:R:I294	R:R:Y312	72.399	4.84	Yes	Yes	0	5	4
15	R:R:I316	R:R:Y312	49.4335	6.04	No	Yes	0	5	4
16	L:L:R7	R:R:Y312	20.1111	5.14	No	Yes	0	0	4
17	L:L:R7	R:R:L309	18.1229	6.07	No	No	0	0	4
18	R:R:L309	R:R:Y313	14.762	4.69	No	Yes	4	4	4
19	R:R:A331	R:R:F337	19.1143	6.93	No	No	0	7	8
20	R:R:F337	R:R:I84	25.8198	3.77	No	No	0	8	7
21	R:R:F99	R:R:I84	27.1598	6.28	Yes	No	0	5	7
22	R:R:F99	R:R:M81	31.1145	8.71	Yes	No	0	5	7
23	R:R:L103	R:R:M81	32.4109	5.65	No	No	0	6	7
24	R:R:L103	R:R:W183	33.4132	4.56	No	Yes	0	6	9
25	R:R:N100	R:R:W183	52.789	6.78	No	Yes	0	9	9
26	R:R:N100	R:R:N179	53.8185	17.71	No	No	0	9	7
27	R:R:N179	R:R:Y97	61.6625	6.98	No	Yes	0	7	7
28	R:R:I178	R:R:Y97	45.92	7.25	No	Yes	0	6	7
29	R:R:I178	R:R:M151	45.5442	4.37	No	No	0	6	6
30	R:R:I182	R:R:M151	45.6586	4.37	No	No	0	7	6
31	R:R:F147	R:R:I182	45.7839	5.02	No	No	0	6	7
32	R:R:F143	R:R:F147	46.0998	5.36	No	No	0	6	6
33	R:R:F143	R:R:V230	44.6835	5.24	No	Yes	0	6	5
34	L:L:Y1	R:R:V230	46.8406	8.83	Yes	Yes	0	0	5
35	R:R:A331	R:R:I98	11.9784	1.62	No	No	0	7	8
36	R:R:I96	R:R:N179	10.1754	4.25	No	No	0	5	7
37	R:R:L149	R:R:N326	49.842	9.61	No	No	0	8	9
38	R:R:L149	R:R:Y330	47.9845	8.21	No	Yes	5	8	9
39	R:R:M152	R:R:Y330	31.4631	7.18	No	Yes	0	8	9
40	R:R:W183	W:W:?1	15.0997	6.68	Yes	Yes	1	9	0
41	R:R:M112	R:R:Y320	12.1473	7.18	Yes	Yes	0	7	6
42	R:R:T199	R:R:W124	18.2482	7.28	Yes	Yes	2	4	8
43	R:R:D128	R:R:T199	31.474	7.23	No	Yes	0	2	4
44	R:R:D128	R:R:G198	33.9579	3.35	No	No	0	2	4
45	R:R:G198	R:R:Q213	36.3983	4.93	No	No	0	4	4
46	R:R:K200	R:R:Q213	37.6021	9.49	Yes	No	0	2	4
47	L:L:R6	R:R:K200	39.7756	12.38	Yes	Yes	7	0	2
48	L:L:R6	R:R:Y219	43.2563	26.75	Yes	No	0	0	1
49	R:R:F214	R:R:Y219	44.4275	7.22	Yes	No	0	6	1
50	R:R:D223	R:R:F214	53.0232	3.58	No	Yes	0	4	6
51	R:R:D223	R:R:K227	54.0636	12.44	No	Yes	0	4	4
52	R:R:I294	R:R:K227	57.6479	4.36	Yes	Yes	8	5	4
53	R:R:F126	R:R:W124	11.5427	18.04	Yes	Yes	2	7	8
54	R:R:I208	R:R:T199	10.2462	1.52	No	Yes	0	4	4
55	R:R:S153	R:R:Y246	23.8752	13.99	No	Yes	0	9	8
56	R:R:R156	R:R:Y246	51.7268	7.2	No	Yes	0	9	8
57	R:R:R156	R:R:Y330	52.6855	5.14	No	Yes	0	9	9
58	R:R:C245	R:R:Y157	12.9807	8.06	No	Yes	0	7	7
59	R:R:C245	R:R:S153	14.3807	3.44	No	No	0	7	9
60	R:R:M249	R:R:Y246	24.8502	3.59	No	Yes	0	8	8
61	R:R:M249	R:R:V160	23.5374	9.13	No	No	0	8	8
62	R:R:H291	R:R:W287	25.2914	8.46	No	Yes	3	8	8
63	R:R:F235	R:R:H291	14.1028	4.53	Yes	No	3	8	8
64	R:R:F235	R:R:T288	11.6734	7.78	Yes	Yes	0	8	5
65	R:R:L253	R:R:L259	19.6372	5.54	No	Yes	0	8	3
66	R:R:L253	R:R:V160	22.192	2.98	No	No	0	8	8
67	R:R:L120	R:R:Y119	10.3878	3.52	No	No	0	4	4
68	R:R:M152	R:R:Y97	30.8149	5.99	No	Yes	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y313	R:R:Y66	7.94	4	Yes	Yes	4	6	1	2
R:R:I316	R:R:Y66	7.25	0	No	Yes	5	6	2	2
R:R:D138	R:R:T111	7.23	6	No	No	6	7	1	2
R:R:T111	R:R:Y320	3.75	6	No	Yes	7	6	2	2
R:R:Q115	R:R:Y320	12.4	0	No	Yes	7	6	1	2
L:L:G3	R:R:Q115	6.58	0	No	No	0	7	0	1
L:L:F4	R:R:Q115	11.71	0	No	No	0	7	0	1
R:R:Y119	R:R:Y313	21.84	0	No	Yes	4	4	2	1
L:L:R9	R:R:N122	13.26	4	No	No	0	5	0	1
L:L:F4	R:R:I135	11.3	0	No	No	0	4	0	1
R:R:D138	R:R:Y320	4.6	6	No	Yes	6	6	1	2
L:L:F4	R:R:D138	7.17	0	No	No	0	6	0	1
R:R:V189	R:R:Y139	3.79	0	No	No	5	5	2	1
L:L:Y1	R:R:Y139	5.96	0	Yes	No	0	5	0	1
R:R:M142	R:R:W287	5.82	0	No	Yes	7	8	1	2
L:L:Y1	R:R:M142	7.18	0	Yes	No	0	7	0	1
R:R:F143	R:R:V189	7.87	0	No	No	6	5	2	2
R:R:F143	R:R:V230	5.24	0	No	Yes	6	5	2	1
R:R:E209	R:R:K200	5.4	7	No	Yes	3	2	1	1
R:R:K200	R:R:Q213	9.49	7	Yes	No	2	4	1	2
L:L:R6	R:R:K200	12.38	7	Yes	Yes	0	2	0	1
L:L:R6	R:R:E209	8.14	7	Yes	No	0	3	0	1
L:L:R6	R:R:S211	3.95	7	Yes	No	0	4	0	1
R:R:F214	R:R:Y219	7.22	0	Yes	No	6	1	2	1
R:R:D223	R:R:F214	3.58	0	No	Yes	4	6	2	2
L:L:R6	R:R:Y219	26.75	7	Yes	No	0	1	0	1
R:R:D223	R:R:K227	12.44	0	No	Yes	4	4	2	1
R:R:M226	R:R:V230	4.56	0	No	Yes	5	5	2	1
R:R:I294	R:R:K227	4.36	8	Yes	Yes	5	4	1	1
R:R:A298	R:R:K227	4.82	0	No	Yes	4	4	2	1
L:L:L5	R:R:K227	7.05	8	No	Yes	0	4	0	1
L:L:Y1	R:R:V230	8.83	0	Yes	Yes	0	5	0	1
R:R:I290	R:R:I294	5.89	0	No	Yes	6	5	2	1
R:R:E297	R:R:F293	10.49	0	No	No	5	5	1	2
R:R:F293	R:R:Y312	10.32	0	No	Yes	5	4	2	1
R:R:I294	R:R:Y312	4.84	8	Yes	Yes	5	4	1	1
L:L:Y1	R:R:I294	3.63	0	Yes	Yes	0	5	0	1
L:L:L5	R:R:I294	4.28	8	No	Yes	0	5	0	1
L:L:R7	R:R:E297	10.47	0	No	No	0	5	0	1
L:L:I8	R:R:H304	7.95	0	No	No	0	1	0	1
R:R:L309	R:R:Y313	4.69	4	No	Yes	4	4	1	1
L:L:R7	R:R:L309	6.07	0	No	No	0	4	0	1
L:L:R9	R:R:L309	13.36	4	No	No	0	4	0	1
R:R:I316	R:R:Y312	6.04	0	No	Yes	5	4	2	1
L:L:R7	R:R:Y312	5.14	0	No	Yes	0	4	0	1
L:L:R9	R:R:Y313	4.12	4	No	Yes	0	4	0	1
R:R:D216	R:R:K200	2.77	0	No	Yes	2	2	2	1
R:R:A234	R:R:V230	1.7	0	No	Yes	6	5	2	1
L:L:I8	R:R:T302	1.52	0	No	No	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:N100	R:R:W183	6.78	0	No	Yes	9	9	2	1
R:R:L103	R:R:L107	4.15	0	No	No	6	6	2	1
R:R:L103	R:R:W183	4.56	0	No	Yes	6	9	2	1
R:R:L107	R:R:N141	13.73	1	No	No	6	8	1	1
R:R:L107	W:W:?1	4.64	1	No	Yes	6	0	1	0
R:R:I194	R:R:S136	6.19	0	No	No	4	5	1	2
R:R:I137	R:R:N141	5.66	1	No	No	5	8	1	1
R:R:I137	W:W:?1	8.37	1	No	Yes	5	0	1	0
R:R:T144	R:R:Y140	4.99	1	Yes	Yes	7	5	2	1
R:R:W183	R:R:Y140	12.54	1	Yes	Yes	9	5	1	1
R:R:S186	R:R:Y140	5.09	1	No	Yes	8	5	2	1
R:R:Y140	W:W:?1	40.25	1	Yes	Yes	5	0	1	0
R:R:N141	W:W:?1	6.9	1	No	Yes	8	0	1	0
R:R:T144	R:R:W183	9.7	1	Yes	Yes	7	9	2	1
R:R:S186	R:R:T144	4.8	1	No	Yes	8	7	2	2
R:R:W183	W:W:?1	6.68	1	Yes	Yes	9	0	1	0
R:R:S187	W:W:?1	5.03	0	No	Yes	4	0	1	0
R:R:G190	W:W:?1	4.3	0	No	Yes	6	0	1	0
R:R:I191	W:W:?1	5.98	0	No	Yes	4	0	1	0
R:R:I194	W:W:?1	3.59	0	No	Yes	4	0	1	0
R:R:I191	R:R:V195	1.54	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9L60_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.58
Number of Linked Nodes	275
Number of Links	288
Number of Hubs	35
Number of Links mediated by Hubs	136
Number of Communities	8
Number of Nodes involved in Communities	35
Number of Links involved in Communities	42

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	36799
Length Of Smallest Path	3
Average Path Length	15.5705
Length of Longest Path	41
Minimum Path Strength	1.07
Average Path Strength	6.87574
Maximum Path Strength	24.31
Minimum Path Correlation	0.7
Average Path Correlation	0.927154
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	47.8213
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7306
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • multicellular organismal process • system process • sensory perception • nervous system process • cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle
Gene Ontology	Cellular Component	• cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • extracellular region • somatodendritic compartment • cell body • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • axon • axon terminus • presynapse • distal axon • neuron projection terminus • binding • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • dynorphin receptor activity • protein binding • receptor serine/threonine kinase binding • signaling receptor binding • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception • nervous system process • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • defense response to virus • defense response • response to other organism • response to stress • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • response to acrylamide • response to chemical • response to oxygen-containing compound • response to nitrogen compound • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to hormone • response to endogenous stimulus • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • cellular response to oxygen-containing compound • response to hexose • cellular response to carbohydrate stimulus • cellular response to chemical stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • response to lipid • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to alcohol • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • regulation of potassium ion transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • perikaryon • cytosol • presynaptic membrane • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • transport vesicle membrane • bounding membrane of organelle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • organelle membrane • exocytic vesicle • mitochondrion • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • cell projection membrane • D2 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • establishment of protein localization • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_W_
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	_W_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>9L60_nogp_Chain_R A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V R E D V D V I E C S L Q F P D D D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T S H S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	doi.org/10.1038/nature10939
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	doi.org/10.1016/j.cell.2017.12.011
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	doi.org/10.1038/s41467-020-14889-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	doi.org/10.1038/s41467-023-37041-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9V6O	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	Gi1/β1/γ2	2.76	2025-11-19	10.1038/s41467-025-64882-1
	9V6O (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-		2.76	2025-11-19	10.1038/s41467-025-64882-1
	9W49	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-	Gi1/β1/γ2	2.9	2025-11-19	10.1038/s41467-025-64882-1
	9W49 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-		2.9	2025-11-19	10.1038/s41467-025-64882-1
	9L60	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15	Gi1/β1/γ2	2.9	2025-12-31	To be published
	9L60 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15		2.9	2025-12-31	To be published

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