psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q115	23.11	Yes	Yes	1	0	7
2	L:L:?1	R:R:V118	4.7	Yes	No	0	0	5
3	L:L:?1	R:R:W124	5.39	Yes	Yes	1	0	8
4	L:L:?1	R:R:D138	24.63	Yes	Yes	1	0	6
5	L:L:?1	R:R:Y139	7.4	Yes	No	0	0	5
6	L:L:?1	R:R:M142	8.93	Yes	No	0	0	7
7	L:L:?1	R:R:W287	4.49	Yes	Yes	1	0	8
8	L:L:?1	R:R:I316	11.26	Yes	Yes	1	0	5
9	L:L:?1	R:R:Y320	11.1	Yes	Yes	1	0	6
10	R:R:I58	R:R:P59	10.16	No	No	0	4	4
11	R:R:P59	R:R:Y119	4.17	No	No	0	4	4
12	R:R:I62	R:R:Y66	3.63	No	Yes	0	5	6
13	R:R:I62	R:R:Y119	4.84	No	No	0	5	4
14	R:R:L120	R:R:T63	5.9	No	No	0	4	5
15	R:R:M112	R:R:Y66	3.59	Yes	Yes	0	7	6
16	R:R:S116	R:R:Y66	3.82	No	Yes	0	6	6
17	R:R:Y313	R:R:Y66	4.96	No	Yes	0	4	6
18	R:R:I316	R:R:Y66	3.63	Yes	Yes	0	5	6
19	R:R:A317	R:R:Y66	6.67	No	Yes	0	5	6
20	R:R:M112	R:R:V69	4.56	Yes	No	0	7	7
21	R:R:T321	R:R:V69	6.35	No	No	0	5	7
22	R:R:F70	R:R:L74	3.65	No	No	0	7	6
23	R:R:F70	R:R:P113	13	No	No	0	7	8
24	R:R:G73	R:R:S324	3.71	No	No	0	8	7
25	R:R:D105	R:R:N77	6.73	Yes	No	2	9	9
26	R:R:A106	R:R:N77	4.69	No	No	0	8	9
27	R:R:N77	R:R:P327	9.77	No	Yes	2	9	9
28	R:R:A102	R:R:V80	3.39	No	No	0	8	9
29	R:R:F99	R:R:M81	16.17	No	No	0	5	7
30	R:R:L103	R:R:M81	5.65	No	No	0	6	7
31	R:R:F82	R:R:I85	3.77	No	No	0	4	3
32	R:R:F82	R:R:R86	4.28	No	No	0	4	5
33	R:R:V83	R:R:Y87	5.05	No	No	0	8	5
34	R:R:F337	R:R:V83	3.93	No	No	0	8	8
35	R:R:I84	R:R:M90	5.83	No	No	3	7	7
36	R:R:I84	R:R:N95	5.66	No	No	0	7	7
37	R:R:F99	R:R:I84	13.82	No	No	3	5	7
38	R:R:C340	R:R:Y87	8.06	No	No	0	6	5
39	R:R:F341	R:R:Y87	10.32	No	No	0	6	5
40	R:R:K89	R:R:K91	8.62	No	No	0	5	7
41	R:R:F99	R:R:M90	3.73	No	No	3	5	7
42	R:R:N95	R:R:T92	4.39	No	No	0	7	7
43	R:R:I96	R:R:K176	4.36	No	No	0	5	4
44	R:R:I96	R:R:N179	4.25	No	Yes	0	5	7
45	R:R:M152	R:R:Y97	4.79	No	Yes	0	8	7
46	R:R:D155	R:R:Y97	9.2	No	Yes	0	8	7
47	R:R:A175	R:R:Y97	4	No	Yes	0	7	7
48	R:R:I178	R:R:Y97	7.25	No	Yes	0	6	7
49	R:R:N179	R:R:Y97	8.14	Yes	Yes	0	7	7
50	R:R:I98	R:R:Y330	18.13	No	Yes	0	8	9
51	R:R:N100	R:R:N179	20.43	No	Yes	0	9	7
52	R:R:N100	R:R:W183	6.78	No	Yes	0	9	9
53	R:R:D105	R:R:L101	6.79	Yes	Yes	2	9	9
54	R:R:L101	R:R:T148	5.9	Yes	No	0	9	7
55	R:R:L101	R:R:L149	6.92	Yes	No	2	9	8
56	R:R:L101	R:R:M152	4.24	Yes	No	0	9	8
57	R:R:L101	R:R:N326	6.87	Yes	Yes	2	9	9
58	R:R:L103	R:R:W183	6.83	No	Yes	0	6	9
59	R:R:A104	R:R:T144	3.36	No	No	0	8	7
60	R:R:A104	R:R:S145	3.42	No	No	0	8	9
61	R:R:D105	R:R:S145	4.42	Yes	No	0	9	9
62	R:R:D105	R:R:S323	5.89	Yes	No	0	9	8
63	R:R:D105	R:R:N326	4.04	Yes	Yes	2	9	9
64	R:R:D105	R:R:P327	9.66	Yes	Yes	2	9	9
65	R:R:L107	R:R:N141	6.87	No	Yes	0	6	8
66	R:R:N141	R:R:V108	13.3	Yes	No	0	8	7
67	R:R:S323	R:R:V108	9.7	No	No	0	8	7
68	R:R:D138	R:R:T111	14.45	Yes	No	1	6	7
69	R:R:N141	R:R:T111	5.85	Yes	No	1	8	7
70	R:R:M112	R:R:P113	3.35	Yes	No	0	7	8
71	R:R:M112	R:R:Y320	25.14	Yes	Yes	0	7	6
72	R:R:F114	R:R:V134	7.87	No	No	0	5	6
73	R:R:Q115	R:R:Y313	3.38	Yes	No	0	7	4
74	R:R:I316	R:R:Q115	8.23	Yes	Yes	1	5	7
75	R:R:Q115	R:R:Y320	10.15	Yes	Yes	1	7	6
76	R:R:F126	R:R:T117	3.89	Yes	No	0	7	4
77	R:R:Y119	R:R:Y313	19.86	No	No	0	4	4
78	R:R:F126	R:R:W124	17.04	Yes	Yes	1	7	8
79	R:R:L130	R:R:W124	3.42	No	Yes	1	5	8
80	R:R:C131	R:R:W124	5.22	No	Yes	1	9	8
81	R:R:C210	R:R:W124	6.53	No	Yes	1	9	8
82	R:R:F126	R:R:P125	10.11	Yes	No	0	7	1
83	R:R:F126	R:R:L130	15.83	Yes	No	1	7	5
84	R:R:D128	R:R:K132	9.68	No	No	0	2	6
85	R:R:D128	R:R:T199	8.67	No	Yes	0	2	4
86	R:R:L130	R:R:V134	4.47	No	No	0	5	6
87	R:R:C131	R:R:T199	5.07	No	Yes	0	9	4
88	R:R:C131	R:R:C210	5.46	No	No	1	9	9
89	R:R:L135	R:R:L212	5.54	No	No	0	4	4
90	R:R:I194	R:R:S136	7.74	No	No	0	4	5
91	R:R:D138	R:R:N141	8.08	Yes	Yes	1	6	8
92	R:R:D138	R:R:Y320	3.45	Yes	Yes	1	6	6
93	R:R:V230	R:R:Y139	3.79	No	No	0	5	5
94	R:R:W183	R:R:Y140	12.54	Yes	No	0	9	5
95	R:R:S187	R:R:Y140	6.36	No	No	0	4	5
96	R:R:F143	R:R:M142	3.73	Yes	No	0	6	7
97	R:R:F143	R:R:V189	6.55	Yes	No	0	6	5
98	R:R:T144	R:R:W183	15.77	No	Yes	0	7	9
99	R:R:S186	R:R:T144	4.8	No	No	0	8	7
100	R:R:I146	R:R:P238	3.39	No	No	0	7	9
101	R:R:F283	R:R:I146	3.77	No	No	1	9	7
102	R:R:I146	R:R:W287	4.7	No	Yes	1	7	8
103	R:R:F147	R:R:I182	6.28	No	No	0	6	7
104	R:R:L149	R:R:N326	8.24	No	Yes	2	8	9
105	R:R:P238	R:R:T150	3.5	No	No	0	9	7
106	R:R:I241	R:R:T150	4.56	No	No	0	6	7
107	R:R:M151	R:R:V154	4.56	No	No	0	6	6
108	R:R:I178	R:R:M151	7.29	No	No	0	6	6
109	R:R:M152	R:R:Y330	11.97	No	Yes	0	8	9
110	R:R:I242	R:R:S153	6.19	No	No	0	8	9
111	R:R:C245	R:R:S153	3.44	No	No	0	7	9
112	R:R:S153	R:R:Y246	5.09	No	No	0	9	8
113	R:R:D155	R:R:R170	14.29	No	Yes	0	8	6
114	R:R:R156	R:R:Y246	9.26	No	No	0	9	8
115	R:R:R156	R:R:Y330	12.35	No	Yes	0	9	9
116	R:R:I158	R:R:Y157	3.63	No	Yes	0	5	7
117	R:R:C161	R:R:Y157	9.41	No	Yes	0	7	7
118	R:R:H162	R:R:Y157	7.62	No	Yes	0	6	7
119	R:R:C245	R:R:Y157	8.06	No	Yes	0	7	7
120	R:R:L248	R:R:Y157	7.03	No	Yes	0	4	7
121	R:R:A159	R:R:R170	6.91	No	Yes	0	8	6
122	R:R:M249	R:R:V160	7.61	No	No	0	8	8
123	R:R:L253	R:R:V160	4.47	Yes	No	0	8	8
124	R:R:H162	R:R:K165	6.55	No	No	0	6	4
125	R:R:A166	R:R:R170	4.15	No	Yes	0	5	6
126	R:R:P172	R:R:T171	3.5	No	No	0	2	7
127	R:R:K174	R:R:T171	10.51	No	No	0	5	7
128	R:R:F214	R:R:L196	12.18	No	No	0	6	4
129	R:R:K200	R:R:Q213	9.49	No	No	0	2	4
130	R:R:F214	R:R:W222	23.05	No	No	0	6	7
131	R:R:W221	R:R:W222	4.69	No	No	0	1	7
132	R:R:D223	R:R:K227	5.53	No	No	0	4	4
133	R:R:I294	R:R:K227	4.36	No	No	0	5	4
134	R:R:F231	R:R:I232	3.77	Yes	No	0	5	5
135	R:R:F231	R:R:F235	5.36	Yes	Yes	1	5	8
136	R:R:F231	R:R:V236	5.24	Yes	No	0	5	4
137	R:R:F231	R:R:H291	10.18	Yes	No	1	5	8
138	R:R:F231	R:R:L295	10.96	Yes	No	0	5	5
139	R:R:F235	R:R:V239	3.93	Yes	Yes	0	8	6
140	R:R:F235	R:R:T288	10.38	Yes	No	0	8	5
141	R:R:F235	R:R:H291	10.18	Yes	No	1	8	8
142	R:R:I237	R:R:P238	3.39	No	No	0	5	9
143	R:R:V276	R:R:Y246	16.4	No	No	0	8	8
144	R:R:I250	R:R:T273	9.12	No	No	0	5	6
145	R:R:R252	R:R:S255	7.91	No	No	0	5	4
146	R:R:R252	R:R:V256	5.23	No	No	0	5	6
147	R:R:L253	R:R:L259	5.54	Yes	Yes	4	8	3
148	R:R:L253	R:R:L269	4.15	Yes	Yes	4	8	6
149	R:R:I272	R:R:L253	4.28	No	Yes	0	7	8
150	R:R:L259	R:R:V256	7.45	Yes	No	0	3	6
151	R:R:L259	R:R:L269	6.92	Yes	Yes	4	3	6
152	R:R:G261	R:R:K265	8.71	No	No	0	3	4
153	R:R:K265	R:R:S262	6.12	No	No	0	4	1
154	R:R:E264	R:R:K265	5.4	No	No	0	3	4
155	R:R:E264	R:R:N268	6.57	No	No	0	3	5
156	R:R:R267	R:R:R270	5.33	No	No	0	4	5
157	R:R:R267	R:R:R271	4.26	No	No	0	4	7
158	R:R:R271	R:R:R274	6.4	No	No	0	7	6
159	R:R:K338	R:R:R271	6.19	No	No	0	8	7
160	R:R:L275	R:R:L333	4.15	No	No	0	8	7
161	R:R:L325	R:R:V282	4.47	No	No	0	6	7
162	R:R:L329	R:R:V282	4.47	No	No	0	8	7
163	R:R:F283	R:R:W287	11.02	No	Yes	1	9	8
164	R:R:F283	R:R:N322	3.62	No	No	1	9	9
165	R:R:C286	R:R:N322	4.72	No	No	0	8	9
166	R:R:H291	R:R:W287	6.35	No	Yes	1	8	8
167	R:R:G319	R:R:W287	4.22	No	Yes	0	7	8
168	R:R:N322	R:R:W287	13.56	No	Yes	1	9	8
169	R:R:P289	R:R:T288	3.5	No	No	0	9	5
170	R:R:C315	R:R:I290	4.91	No	No	0	7	6
171	R:R:I290	R:R:I316	5.89	No	Yes	0	6	5
172	R:R:E297	R:R:F293	8.16	No	No	0	5	5
173	R:R:F293	R:R:S311	3.96	No	No	0	5	4
174	R:R:F293	R:R:Y312	5.16	No	No	0	5	4
175	R:R:I294	R:R:Y312	3.63	No	No	0	5	4
176	R:R:F314	R:R:L318	7.31	No	No	0	5	8
177	R:R:I316	R:R:Y320	3.63	Yes	Yes	1	5	6
178	R:R:N326	R:R:P327	4.89	Yes	Yes	2	9	9
179	R:R:D334	R:R:Y330	5.75	No	Yes	0	8	9
180	R:R:E335	R:R:N336	10.52	No	No	0	4	6
181	R:R:F337	R:R:F341	6.43	No	No	0	8	6
182	R:R:G198	R:R:Q213	3.29	No	No	0	4	4
183	R:R:L318	R:R:P289	3.28	No	No	0	8	9
184	R:R:S324	R:R:V69	3.23	No	No	0	7	7
185	R:R:A298	R:R:K227	3.21	No	No	0	4	4
186	R:R:V239	R:R:V284	3.21	Yes	No	0	6	6
187	R:R:S324	R:R:T109	3.2	No	No	0	7	6
188	R:R:T92	R:R:T94	3.14	No	No	0	7	8
189	R:R:I133	R:R:V134	3.07	No	No	0	5	6
190	R:R:I243	R:R:V239	3.07	No	Yes	0	5	6
191	R:R:I243	R:R:V280	3.07	No	No	0	5	8
192	R:R:I208	R:R:T199	3.04	No	Yes	0	4	4
193	R:R:L74	R:R:S78	3	No	No	0	6	4
194	R:R:L79	R:R:V75	2.98	No	No	0	6	4
195	R:R:L196	R:R:V195	2.98	No	No	0	4	4
196	R:R:L248	R:R:V244	2.98	No	No	0	4	4
197	R:R:L269	R:R:T273	2.95	Yes	No	0	6	6
198	R:R:D266	R:R:S260	2.94	No	No	0	3	4
199	R:R:I290	R:R:I294	2.94	No	No	0	6	5
200	R:R:N95	R:R:T88	2.92	No	No	0	7	6
201	R:R:I182	R:R:M151	2.92	No	No	0	7	6
202	R:R:I194	R:R:K132	2.91	No	No	0	4	6
203	R:R:I177	R:R:L173	2.85	No	No	0	3	4
204	R:R:I180	R:R:L184	2.85	No	No	0	4	4
205	R:R:I228	R:R:L295	2.85	No	No	0	5	5
206	R:R:L212	R:R:M226	2.83	No	No	0	4	5
207	R:R:K254	R:R:L251	2.82	No	No	0	4	4
208	R:R:K254	R:R:L269	2.82	No	Yes	0	4	6
209	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
210	R:R:C161	R:R:R252	2.79	No	No	0	7	5
211	R:R:C229	R:R:F233	2.79	No	No	0	3	4
212	R:R:A234	R:R:F143	2.77	No	Yes	0	6	6
213	R:R:L258	R:R:L259	2.77	No	Yes	0	5	3
214	R:R:L329	R:R:N326	2.75	No	Yes	0	8	9
215	R:R:A93	R:R:Y97	2.67	No	Yes	0	6	7
216	R:R:F147	R:R:L185	2.44	No	No	0	6	4
217	R:R:L333	R:R:R274	2.43	No	No	0	7	6
218	R:R:L135	R:R:Y139	2.34	No	No	0	4	5
219	R:R:F143	R:R:F233	2.14	Yes	No	0	6	4
220	R:R:G197	R:R:G198	2.11	No	No	0	4	4
221	R:R:F225	R:R:W222	2	No	No	0	4	7
222	R:R:A193	R:R:G190	1.95	No	No	0	5	6
223	R:R:G190	R:R:S136	1.86	No	No	0	6	5
224	R:R:G73	R:R:V72	1.84	No	No	0	8	5
225	R:R:G76	R:R:V75	1.84	No	No	0	7	4
226	R:R:G198	R:R:T199	1.82	No	Yes	0	4	4
227	R:R:P327	R:R:V80	1.77	Yes	No	0	9	9
228	R:R:G76	R:R:I328	1.76	No	No	0	7	7
229	R:R:C286	R:R:V285	1.71	No	No	0	8	6
230	R:R:A331	R:R:V80	1.7	No	No	0	7	9
231	R:R:I96	R:R:P172	1.69	No	No	0	5	2
232	R:R:C181	R:R:I177	1.64	No	No	0	4	3
233	R:R:V68	R:R:V72	1.6	No	No	0	5	5
234	R:R:V71	R:R:V75	1.6	No	No	0	5	4
235	R:R:A298	R:R:L224	1.58	No	No	0	4	3
236	R:R:T109	R:R:T110	1.57	No	No	0	6	4
237	R:R:I58	R:R:S310	1.55	No	No	0	4	2
238	R:R:I61	R:R:V65	1.54	No	No	0	5	5
239	R:R:I328	R:R:V72	1.54	No	No	0	7	5
240	R:R:I191	R:R:V195	1.54	No	No	0	4	4
241	R:R:I292	R:R:V296	1.54	No	No	0	5	4
242	R:R:H162	R:R:P163	1.53	No	No	0	6	8
243	R:R:I62	R:R:T63	1.52	No	No	0	5	5
244	R:R:I243	R:R:T247	1.52	No	No	0	5	4
245	R:R:I292	R:R:T288	1.52	No	No	0	5	5
246	R:R:K91	R:R:T92	1.5	No	No	0	7	7
247	R:R:L240	R:R:V239	1.49	No	Yes	0	3	6
248	R:R:L275	R:R:V279	1.49	No	No	0	8	8
249	R:R:L329	R:R:V279	1.49	No	No	0	8	8
250	R:R:L173	R:R:T171	1.47	No	No	0	4	7
251	R:R:L277	R:R:T273	1.47	No	No	0	4	6
252	R:R:Q213	R:R:S211	1.44	No	No	0	4	4
253	R:R:I137	R:R:L107	1.43	No	No	0	5	6
254	R:R:E209	R:R:V207	1.43	No	No	0	3	3
255	R:R:I180	R:R:N179	1.42	No	Yes	0	4	7
256	R:R:L120	R:R:M121	1.41	No	No	0	4	4
257	R:R:D334	R:R:N336	1.35	No	No	0	8	6
258	R:R:F332	R:R:L333	1.22	No	No	0	6	7
259	R:R:D168	R:R:F169	1.19	No	No	0	4	4
260	R:R:D334	R:R:F337	1.19	No	No	0	8	8
261	R:R:F169	R:R:R170	1.07	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.2233	9	1	0
2	R:R:Y66	4.38333	6	0	6
3	R:R:Y97	6.00833	6	0	7
4	R:R:L101	6.144	5	2	9
5	R:R:D105	6.255	6	2	9
6	R:R:M112	9.16	4	0	7
7	R:R:Q115	11.2175	4	1	7
8	R:R:W124	6.735	6	1	8
9	R:R:F126	11.7175	4	1	7
10	R:R:D138	12.6525	4	1	6
11	R:R:N141	8.525	4	1	8
12	R:R:F143	3.7975	4	0	6
13	R:R:Y157	7.15	5	0	7
14	R:R:R170	6.605	4	0	6
15	R:R:N179	8.56	4	0	7
16	R:R:W183	10.48	4	0	9
17	R:R:T199	4.65	4	0	4
18	R:R:F231	7.102	5	1	5
19	R:R:F235	7.4625	4	1	8
20	R:R:V239	2.925	4	0	6
21	R:R:L253	4.61	4	4	8
22	R:R:L259	5.67	4	4	3
23	R:R:L269	4.21	4	4	6
24	R:R:W287	7.39	6	1	8
25	R:R:I316	6.528	5	1	5
26	R:R:Y320	10.694	5	1	6
27	R:R:N326	5.358	5	2	9
28	R:R:P327	6.5225	4	2	9
29	R:R:Y330	12.05	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I316	20.5599	11.26	Yes	Yes	1	0	5
2	R:R:I316	R:R:Y66	14.6899	3.63	Yes	Yes	0	5	6
3	R:R:I62	R:R:Y66	11.5774	3.63	No	Yes	0	5	6
4	R:R:M112	R:R:Y320	26.6647	25.14	Yes	Yes	0	7	6
5	R:R:M112	R:R:V69	18.23	4.56	Yes	No	0	7	7
6	R:R:S324	R:R:V69	15.5569	3.23	No	No	0	7	7
7	R:R:G73	R:R:S324	11.457	3.71	No	No	0	8	7
8	L:L:?1	R:R:D138	64.7261	24.63	Yes	Yes	1	0	6
9	R:R:D138	R:R:N141	99.9097	8.08	Yes	Yes	1	6	8
10	R:R:N141	R:R:V108	100	13.3	Yes	No	0	8	7
11	R:R:S323	R:R:V108	99.7893	9.7	No	No	0	8	7
12	R:R:D105	R:R:S323	99.5665	5.89	Yes	No	0	9	8
13	R:R:D105	R:R:S145	21.0536	4.42	Yes	No	0	9	9
14	R:R:A104	R:R:S145	19.7712	3.42	No	No	0	8	9
15	R:R:A104	R:R:T144	18.6334	3.36	No	No	0	8	7
16	R:R:T144	R:R:W183	17.0078	15.77	No	Yes	0	7	9
17	R:R:L103	R:R:W183	16.7489	6.83	No	Yes	0	6	9
18	R:R:L103	R:R:M81	15.286	5.65	No	No	0	6	7
19	R:R:F99	R:R:M81	13.811	16.17	No	No	0	5	7
20	R:R:D105	R:R:L101	68.2119	6.79	Yes	Yes	2	9	9
21	R:R:L101	R:R:M152	73.5882	4.24	Yes	No	0	9	8
22	R:R:M152	R:R:Y330	54.1963	11.97	No	Yes	0	8	9
23	R:R:D334	R:R:Y330	15.1776	5.75	No	Yes	0	8	9
24	R:R:D334	R:R:F337	10.6803	1.19	No	No	0	8	8
25	R:R:F99	R:R:I84	10.7827	13.82	No	No	3	5	7
26	R:R:M152	R:R:Y97	39.9097	4.79	No	Yes	0	8	7
27	R:R:N179	R:R:Y97	22.7995	8.14	Yes	Yes	0	7	7
28	R:R:I96	R:R:N179	12.3721	4.25	No	Yes	0	5	7
29	R:R:D105	R:R:N326	14.2324	4.04	Yes	Yes	2	9	9
30	L:L:?1	R:R:W124	29.0909	5.39	Yes	Yes	1	0	8
31	R:R:C131	R:R:W124	18.1156	5.22	No	Yes	1	9	8
32	R:R:C131	R:R:T199	16.9777	5.07	No	Yes	0	9	4
33	L:L:?1	R:R:W287	35.9843	4.49	Yes	Yes	1	0	8
34	R:R:R156	R:R:Y330	40.1806	12.35	No	Yes	0	9	9
35	R:R:R156	R:R:Y246	39.115	9.26	No	No	0	9	8
36	R:R:S153	R:R:Y246	36.9597	5.09	No	No	0	9	8
37	R:R:C245	R:R:S153	34.3588	3.44	No	No	0	7	9
38	R:R:C245	R:R:Y157	33.0403	8.06	No	Yes	0	7	7
39	R:R:C161	R:R:Y157	23.4738	9.41	No	Yes	0	7	7
40	R:R:C161	R:R:R252	22.0409	2.79	No	No	0	7	5
41	R:R:R252	R:R:V256	19.3799	5.23	No	No	0	5	6
42	R:R:L259	R:R:V256	17.929	7.45	Yes	No	0	3	6
43	R:R:I290	R:R:I316	23.9253	5.89	No	Yes	0	6	5
44	R:R:I290	R:R:I294	19.6388	2.94	No	No	0	6	5
45	R:R:H291	R:R:W287	24.13	6.35	No	Yes	1	8	8
46	R:R:F235	R:R:H291	16.5864	10.18	Yes	No	1	8	8
47	R:R:L329	R:R:N326	17.8326	2.75	No	Yes	0	8	9
48	R:R:L329	R:R:V279	13.4678	1.49	No	No	0	8	8
49	R:R:L275	R:R:V279	12.2216	1.49	No	No	0	8	8
50	R:R:L275	R:R:L333	10.7285	4.15	No	No	0	8	7
51	R:R:G73	R:R:V72	10.0662	1.84	No	No	0	8	5
52	R:R:D138	R:R:Y320	36.0506	3.45	Yes	Yes	1	6	6
53	R:R:I316	R:R:Y320	14.7803	3.63	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q115	23.11	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V118	4.7	1	Yes	No	0	5	0	1
L:L:?1	R:R:W124	5.39	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:D138	24.63	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y139	7.4	1	Yes	No	0	5	0	1
L:L:?1	R:R:M142	8.93	1	Yes	No	0	7	0	1
L:L:?1	R:R:W287	4.49	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I316	11.26	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y320	11.1	1	Yes	Yes	0	6	0	1
R:R:M112	R:R:Y66	3.59	0	Yes	Yes	7	6	2	2
R:R:Y313	R:R:Y66	4.96	0	No	Yes	4	6	2	2
R:R:I316	R:R:Y66	3.63	1	Yes	Yes	5	6	1	2
R:R:D138	R:R:T111	14.45	1	Yes	No	6	7	1	2
R:R:N141	R:R:T111	5.85	1	Yes	No	8	7	2	2
R:R:M112	R:R:Y320	25.14	0	Yes	Yes	7	6	2	1
R:R:Q115	R:R:Y313	3.38	1	Yes	No	7	4	1	2
R:R:I316	R:R:Q115	8.23	1	Yes	Yes	5	7	1	1
R:R:Q115	R:R:Y320	10.15	1	Yes	Yes	7	6	1	1
R:R:F126	R:R:W124	17.04	1	Yes	Yes	7	8	2	1
R:R:L130	R:R:W124	3.42	1	No	Yes	5	8	2	1
R:R:C131	R:R:W124	5.22	1	No	Yes	9	8	2	1
R:R:C210	R:R:W124	6.53	1	No	Yes	9	8	2	1
R:R:F126	R:R:L130	15.83	1	Yes	No	7	5	2	2
R:R:C131	R:R:C210	5.46	1	No	No	9	9	2	2
R:R:D138	R:R:N141	8.08	1	Yes	Yes	6	8	1	2
R:R:D138	R:R:Y320	3.45	1	Yes	Yes	6	6	1	1
R:R:V230	R:R:Y139	3.79	0	No	No	5	5	2	1
R:R:F143	R:R:M142	3.73	0	Yes	No	6	7	2	1
R:R:F283	R:R:I146	3.77	1	No	No	9	7	2	2
R:R:I146	R:R:W287	4.7	1	No	Yes	7	8	2	1
R:R:F283	R:R:W287	11.02	1	No	Yes	9	8	2	1
R:R:F283	R:R:N322	3.62	1	No	No	9	9	2	2
R:R:H291	R:R:W287	6.35	1	No	Yes	8	8	2	1
R:R:G319	R:R:W287	4.22	0	No	Yes	7	8	2	1
R:R:N322	R:R:W287	13.56	1	No	Yes	9	8	2	1
R:R:I290	R:R:I316	5.89	0	No	Yes	6	5	2	1
R:R:I316	R:R:Y320	3.63	1	Yes	Yes	5	6	1	1
R:R:G127	R:R:W124	2.81	0	No	Yes	7	8	2	1
R:R:L135	R:R:Y139	2.34	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9W49_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	247
Number of Links	261
Number of Hubs	29
Number of Links mediated by Hubs	111
Number of Communities	4
Number of Nodes involved in Communities	31
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	30047
Length Of Smallest Path	3
Average Path Length	13.2991
Length of Longest Path	30
Minimum Path Strength	1.13
Average Path Strength	7.3493
Maximum Path Strength	20.73
Minimum Path Correlation	0.7
Average Path Correlation	0.916917
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.0362
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.1275
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neuropeptide binding • peptide binding • peptide receptor activity • molecular transducer activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • dynorphin receptor activity • receptor serine/threonine kinase binding • signaling receptor binding • ovulation cycle • rhythmic process • estrous cycle • reproductive process • multicellular organismal reproductive process • G protein-coupled opioid receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavior • learning • learning or memory • cognition • conditioned place preference • associative learning • biological process involved in interspecies interaction between organisms • defense response to virus • defense response • response to other organism • response to stress • response to external stimulus • response to external biotic stimulus • response to virus • response to biotic stimulus • response to acrylamide • neuropeptide signaling pathway • locomotory behavior • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • response to estrogen • immune response • immune system process • homeostatic process • cellular response to glucose stimulus • intracellular glucose homeostasis • response to hexose • cellular response to carbohydrate stimulus • cellular homeostasis • response to monosaccharide • response to carbohydrate • chemical homeostasis • response to glucose • glucose homeostasis • carbohydrate homeostasis • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • maternal behavior • parental behavior • reproductive behavior • regulation of localization • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of hormone levels • establishment of localization • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • secretion by cell • regulation of secretion by cell • signal release • negative regulation of cellular process • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • regulation of cell communication • eating behavior • feeding behavior • sensory perception of temperature stimulus • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • response to molecule of bacterial origin • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting opioid receptor signaling pathway • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • positive regulation of biological process • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of secretion • positive regulation of cellular process • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • positive regulation of transport • regulation of amine transport • regulation of dopamine secretion • regulation of body fluid levels • secretion by tissue • digestive system process • regulation of digestive system process • body fluid secretion • digestion • saliva secretion • regulation of saliva secretion • response to ethanol • response to peptide hormone • response to insulin • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • p38MAPK cascade • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • positive regulation of p38MAPK cascade • regulation of response to stimulus • regulation of p38MAPK cascade • MAPK cascade • positive regulation of signaling • regulation of eating behavior • positive regulation of feeding behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • sensory perception of pain • response to nicotine • positive regulation of cation transmembrane transport • regulation of potassium ion transport • monoatomic ion transmembrane transport • potassium ion transmembrane transport • regulation of monoatomic ion transmembrane transport • metal ion transport • monoatomic cation transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • regulation of monoatomic ion transport • regulation of potassium ion transmembrane transport • transmembrane transport • positive regulation of potassium ion transport • regulation of transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of monoatomic cation transmembrane transport • potassium ion transport • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • presynaptic membrane • dendrite • dendritic tree • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • intracellular vesicle • transport vesicle membrane • cytoplasmic vesicle • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • secretory vesicle • exocytic vesicle • mitochondrion • axon • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>9W49_nogp_Chain_R I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V I E C S L Q F W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C F L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	doi.org/10.1038/nature10939
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	doi.org/10.1016/j.cell.2017.12.011
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	doi.org/10.1038/s41467-020-14889-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	doi.org/10.1038/s41467-023-37041-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9V6O	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	Gi1/β1/γ2	2.76	2025-11-19	10.1038/s41467-025-64882-1
	9V6O (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-		2.76	2025-11-19	10.1038/s41467-025-64882-1
	9W49	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-	Gi1/β1/γ2	2.9	2025-11-19	10.1038/s41467-025-64882-1
	9W49 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-		2.9	2025-11-19	10.1038/s41467-025-64882-1
	9L60	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15	Gi1/β1/γ2	2.9	2025-12-31	To be published
	9L60 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15		2.9	2025-12-31	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9W49_nogp.zip

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