psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q115	16.2	Yes	No	1	0	7
2	L:L:?1	R:R:L135	4.43	Yes	Yes	1	0	7
3	L:L:?1	R:R:D138	21.74	Yes	No	0	0	6
4	L:L:?1	R:R:Y139	18.03	Yes	No	1	0	5
5	L:L:?1	R:R:M142	7.25	Yes	No	1	0	7
6	L:L:?1	R:R:V230	3.82	Yes	No	0	0	5
7	L:L:?1	R:R:W287	6.57	Yes	Yes	1	0	8
8	L:L:?1	R:R:I290	4.57	Yes	No	1	0	6
9	L:L:?1	R:R:H291	4.94	Yes	Yes	1	0	8
10	L:L:?1	R:R:I294	14.63	Yes	Yes	1	0	5
11	L:L:?1	R:R:Y312	4.51	Yes	Yes	1	0	4
12	L:L:?1	R:R:I316	3.66	Yes	Yes	1	0	5
13	L:L:?1	R:R:Y320	11.27	Yes	Yes	1	0	6
14	R:R:A57	R:R:V60	3.39	No	No	0	4	5
15	R:R:I58	R:R:P59	8.47	No	No	0	4	4
16	R:R:I58	R:R:I62	4.42	No	No	0	4	5
17	R:R:I58	R:R:S310	4.64	No	No	0	4	2
18	R:R:P59	R:R:Y119	6.95	No	Yes	0	4	4
19	R:R:T63	R:R:V60	3.17	No	No	0	5	5
20	R:R:I62	R:R:Y119	12.09	No	Yes	0	5	4
21	R:R:L120	R:R:T63	4.42	No	No	0	4	5
22	R:R:M112	R:R:Y66	4.79	Yes	No	0	7	6
23	R:R:Y313	R:R:Y66	3.97	No	No	0	4	6
24	R:R:A317	R:R:Y66	5.34	No	No	0	5	6
25	R:R:T321	R:R:V69	4.76	No	No	0	5	7
26	R:R:S324	R:R:V69	3.23	No	No	0	7	7
27	R:R:F70	R:R:M112	4.98	No	Yes	1	7	7
28	R:R:F70	R:R:P113	4.33	No	No	1	7	8
29	R:R:G73	R:R:S324	3.71	No	No	0	8	7
30	R:R:L79	R:R:V75	4.47	No	No	0	6	4
31	R:R:D105	R:R:N77	6.73	Yes	No	2	9	9
32	R:R:A106	R:R:N77	6.25	No	No	0	8	9
33	R:R:N77	R:R:P327	6.52	No	Yes	2	9	9
34	R:R:F82	R:R:S78	5.28	No	No	0	4	4
35	R:R:A102	R:R:V80	3.39	No	No	0	8	9
36	R:R:P327	R:R:V80	3.53	Yes	No	0	9	9
37	R:R:F82	R:R:M81	3.73	No	No	0	4	7
38	R:R:I85	R:R:M81	4.37	No	No	0	3	7
39	R:R:V83	R:R:Y87	5.05	No	No	0	8	5
40	R:R:I84	R:R:M90	5.83	No	Yes	3	7	7
41	R:R:I84	R:R:N95	4.25	No	Yes	3	7	7
42	R:R:F99	R:R:I84	3.77	No	No	3	5	7
43	R:R:N336	R:R:T88	5.85	No	No	0	6	6
44	R:R:K89	R:R:K91	10.06	No	No	0	5	7
45	R:R:M90	R:R:N95	4.21	Yes	Yes	3	7	7
46	R:R:I96	R:R:M90	8.75	Yes	Yes	0	5	7
47	R:R:F99	R:R:M90	7.46	No	Yes	3	5	7
48	R:R:N95	R:R:T92	5.85	Yes	No	0	7	7
49	R:R:A175	R:R:I96	3.25	No	Yes	0	7	5
50	R:R:I96	R:R:K176	5.82	Yes	No	0	5	4
51	R:R:I96	R:R:N179	4.25	Yes	No	0	5	7
52	R:R:M151	R:R:Y97	5.99	Yes	Yes	4	6	7
53	R:R:M152	R:R:Y97	5.99	No	Yes	0	8	7
54	R:R:D155	R:R:Y97	8.05	No	Yes	0	8	7
55	R:R:A175	R:R:Y97	4	No	Yes	0	7	7
56	R:R:I178	R:R:Y97	4.84	No	Yes	4	6	7
57	R:R:N179	R:R:Y97	8.14	No	Yes	0	7	7
58	R:R:I98	R:R:Y330	15.71	No	Yes	0	8	9
59	R:R:F99	R:R:L103	8.53	No	No	0	5	6
60	R:R:N100	R:R:N179	17.71	No	No	0	9	7
61	R:R:D105	R:R:L101	9.5	Yes	Yes	2	9	9
62	R:R:L101	R:R:T148	4.42	Yes	No	0	9	7
63	R:R:L101	R:R:M152	4.24	Yes	No	0	9	8
64	R:R:L101	R:R:N326	12.36	Yes	No	2	9	9
65	R:R:A104	R:R:T144	3.36	No	No	0	8	7
66	R:R:D105	R:R:S323	5.89	Yes	No	0	9	8
67	R:R:D105	R:R:N326	5.39	Yes	No	2	9	9
68	R:R:D105	R:R:P327	9.66	Yes	Yes	2	9	9
69	R:R:L107	R:R:N141	13.73	No	No	0	6	8
70	R:R:S323	R:R:V108	6.46	No	No	0	8	7
71	R:R:S324	R:R:T109	3.2	No	No	0	7	6
72	R:R:D138	R:R:T111	7.23	No	No	0	6	7
73	R:R:M112	R:R:P113	3.35	Yes	No	1	7	8
74	R:R:M112	R:R:Y320	23.95	Yes	Yes	1	7	6
75	R:R:F114	R:R:W124	5.01	No	Yes	1	5	8
76	R:R:F114	R:R:F126	9.65	No	No	1	5	7
77	R:R:F114	R:R:V134	10.49	No	No	1	5	6
78	R:R:I316	R:R:Q115	6.86	Yes	No	1	5	7
79	R:R:Q115	R:R:Y320	7.89	No	Yes	1	7	6
80	R:R:S116	R:R:T117	3.2	No	No	0	6	4
81	R:R:V118	R:R:Y313	5.05	No	No	0	5	4
82	R:R:S310	R:R:Y119	3.82	No	Yes	0	2	4
83	R:R:Y119	R:R:Y313	21.84	Yes	No	0	4	4
84	R:R:M121	R:R:P125	6.71	No	No	0	4	1
85	R:R:F126	R:R:W124	7.02	No	Yes	1	7	8
86	R:R:C131	R:R:W124	5.22	No	Yes	1	9	8
87	R:R:V134	R:R:W124	4.9	No	Yes	1	6	8
88	R:R:C210	R:R:W124	13.06	No	Yes	1	9	8
89	R:R:F126	R:R:L130	3.65	No	No	0	7	5
90	R:R:D128	R:R:T199	11.56	No	Yes	0	2	4
91	R:R:C131	R:R:T199	3.38	No	Yes	0	9	4
92	R:R:C131	R:R:C210	7.28	No	No	1	9	9
93	R:R:I133	R:R:I194	4.42	No	Yes	0	5	4
94	R:R:L135	R:R:Y139	5.86	Yes	No	1	7	5
95	R:R:C210	R:R:L135	3.17	No	Yes	1	9	7
96	R:R:I194	R:R:S136	9.29	Yes	No	0	4	5
97	R:R:I137	R:R:Y140	3.63	No	Yes	5	5	5
98	R:R:I137	R:R:N141	4.25	No	No	5	5	8
99	R:R:N141	R:R:Y140	10.47	No	Yes	5	8	5
100	R:R:T144	R:R:Y140	7.49	No	Yes	0	7	5
101	R:R:W183	R:R:Y140	7.72	No	Yes	0	9	5
102	R:R:F143	R:R:M142	3.73	Yes	No	0	6	7
103	R:R:M142	R:R:W287	4.65	No	Yes	1	7	8
104	R:R:F143	R:R:F147	6.43	Yes	No	0	6	6
105	R:R:F143	R:R:V230	3.93	Yes	No	0	6	5
106	R:R:S186	R:R:T144	6.4	No	No	0	8	7
107	R:R:I146	R:R:P238	3.39	No	No	0	7	9
108	R:R:F283	R:R:I146	5.02	No	No	1	9	7
109	R:R:I146	R:R:W287	5.87	No	Yes	1	7	8
110	R:R:F283	R:R:L149	7.31	No	No	0	9	8
111	R:R:P238	R:R:T150	3.5	No	No	0	9	7
112	R:R:I241	R:R:T150	4.56	No	No	0	6	7
113	R:R:I242	R:R:T150	7.6	No	No	0	8	7
114	R:R:M151	R:R:V154	6.09	Yes	No	0	6	6
115	R:R:I178	R:R:M151	4.37	No	Yes	4	6	6
116	R:R:M152	R:R:Y330	8.38	No	Yes	0	8	9
117	R:R:I242	R:R:S153	6.19	No	No	0	8	9
118	R:R:C245	R:R:S153	3.44	No	No	0	7	9
119	R:R:S153	R:R:Y246	6.36	No	No	0	9	8
120	R:R:C245	R:R:V154	3.42	No	No	0	7	6
121	R:R:D155	R:R:R170	15.48	No	No	0	8	6
122	R:R:R156	R:R:Y246	8.23	No	No	0	9	8
123	R:R:R156	R:R:Y330	10.29	No	Yes	0	9	9
124	R:R:I158	R:R:Y157	3.63	No	Yes	0	5	7
125	R:R:C161	R:R:Y157	9.41	No	Yes	0	7	7
126	R:R:H162	R:R:Y157	6.53	No	Yes	0	6	7
127	R:R:C245	R:R:Y157	6.72	No	Yes	0	7	7
128	R:R:L248	R:R:Y157	7.03	No	Yes	0	4	7
129	R:R:A159	R:R:R170	5.53	No	No	0	8	6
130	R:R:M249	R:R:V160	7.61	No	No	0	8	8
131	R:R:L253	R:R:V160	7.45	No	No	0	8	8
132	R:R:H162	R:R:K165	6.55	No	No	0	6	4
133	R:R:P172	R:R:T171	3.5	No	No	0	2	7
134	R:R:K174	R:R:T171	7.51	No	No	0	5	7
135	R:R:L184	R:R:W183	5.69	No	No	0	4	9
136	R:R:G198	R:R:Q213	4.93	No	No	0	4	4
137	R:R:I208	R:R:T199	7.6	No	Yes	0	4	4
138	R:R:K200	R:R:Q213	4.07	No	No	0	2	4
139	R:R:L212	R:R:M226	7.07	No	No	0	4	5
140	R:R:D223	R:R:K227	9.68	No	No	0	4	4
141	R:R:I294	R:R:K227	5.82	Yes	No	0	5	4
142	R:R:A298	R:R:K227	3.21	No	No	0	4	4
143	R:R:I228	R:R:L295	5.71	No	No	0	5	5
144	R:R:F231	R:R:F235	5.36	Yes	Yes	1	5	8
145	R:R:F231	R:R:V236	3.93	Yes	No	0	5	4
146	R:R:F231	R:R:H291	9.05	Yes	Yes	1	5	8
147	R:R:F231	R:R:L295	9.74	Yes	No	0	5	5
148	R:R:F235	R:R:V239	5.24	Yes	No	0	8	6
149	R:R:F235	R:R:T288	6.49	Yes	No	0	8	5
150	R:R:F235	R:R:H291	9.05	Yes	Yes	1	8	8
151	R:R:I237	R:R:P238	3.39	No	No	0	5	9
152	R:R:V239	R:R:V284	3.21	No	No	0	6	6
153	R:R:V276	R:R:Y246	10.09	No	No	0	8	8
154	R:R:I250	R:R:T273	7.6	No	No	0	5	6
155	R:R:I250	R:R:V276	6.14	No	No	0	5	8
156	R:R:K254	R:R:L269	5.64	No	No	0	4	6
157	R:R:L259	R:R:V256	5.96	No	No	0	3	6
158	R:R:G261	R:R:K265	3.49	No	No	0	3	4
159	R:R:D266	R:R:R270	5.96	No	No	0	3	5
160	R:R:R267	R:R:R270	11.73	No	No	6	4	5
161	R:R:R267	R:R:R274	4.26	No	No	6	4	6
162	R:R:R270	R:R:R274	7.46	No	No	6	5	6
163	R:R:E335	R:R:R271	15.12	No	No	0	4	7
164	R:R:L275	R:R:L333	6.92	No	No	0	8	7
165	R:R:F283	R:R:W287	11.02	No	Yes	1	9	8
166	R:R:C286	R:R:T321	3.38	No	No	0	8	5
167	R:R:C286	R:R:N322	4.72	No	Yes	0	8	9
168	R:R:H291	R:R:W287	7.41	Yes	Yes	1	8	8
169	R:R:N322	R:R:W287	14.69	Yes	Yes	0	9	8
170	R:R:P289	R:R:T288	3.5	No	No	0	9	5
171	R:R:C315	R:R:P289	3.77	No	No	0	7	9
172	R:R:L318	R:R:P289	4.93	No	No	0	8	9
173	R:R:I290	R:R:I294	5.89	No	Yes	1	6	5
174	R:R:C315	R:R:I290	3.27	No	No	0	7	6
175	R:R:F293	R:R:S311	5.28	No	No	0	5	4
176	R:R:F293	R:R:Y312	8.25	No	Yes	0	5	4
177	R:R:I294	R:R:Y312	7.25	Yes	Yes	1	5	4
178	R:R:I316	R:R:Y312	3.63	Yes	Yes	1	5	4
179	R:R:I316	R:R:Y320	3.63	Yes	Yes	1	5	6
180	R:R:I328	R:R:L325	4.28	No	No	0	7	6
181	R:R:L325	R:R:L329	5.54	No	No	0	6	8
182	R:R:N326	R:R:P327	9.77	No	Yes	2	9	9
183	R:R:D334	R:R:Y330	6.9	No	Yes	0	8	9
184	R:R:D334	R:R:F337	3.58	No	No	0	8	8
185	R:R:M121	R:R:S123	3.07	No	No	0	4	4
186	R:R:I232	R:R:V236	3.07	No	No	0	5	4
187	R:R:I243	R:R:V239	3.07	No	No	0	5	6
188	R:R:I243	R:R:V280	3.07	No	No	0	5	8
189	R:R:M226	R:R:V230	3.04	No	No	0	5	5
190	R:R:M121	R:R:T117	3.01	No	No	0	4	4
191	R:R:F214	R:R:W222	3.01	No	No	0	6	7
192	R:R:L248	R:R:V244	2.98	No	No	0	4	4
193	R:R:L107	R:R:T110	2.95	No	No	0	6	4
194	R:R:I61	R:R:I62	2.94	No	No	0	5	5
195	R:R:D105	R:R:S145	2.94	Yes	No	0	9	9
196	R:R:N95	R:R:T88	2.92	Yes	No	0	7	6
197	R:R:I182	R:R:M151	2.92	No	Yes	0	7	6
198	R:R:E209	R:R:V118	2.85	No	No	0	3	5
199	R:R:I177	R:R:L173	2.85	No	No	0	3	4
200	R:R:I180	R:R:L184	2.85	No	No	0	4	4
201	R:R:I272	R:R:L253	2.85	No	No	0	7	8
202	R:R:K265	R:R:L258	2.82	No	No	0	4	5
203	R:R:G127	R:R:W124	2.81	No	Yes	0	7	8
204	R:R:C161	R:R:R252	2.79	No	No	0	7	5
205	R:R:C229	R:R:F233	2.79	No	No	0	3	4
206	R:R:A234	R:R:F143	2.77	No	Yes	0	6	6
207	R:R:A166	R:R:R170	2.77	No	No	0	5	6
208	R:R:L196	R:R:L212	2.77	No	No	0	4	4
209	R:R:L224	R:R:L299	2.77	No	No	0	3	4
210	R:R:A331	R:R:F337	2.77	No	No	0	7	8
211	R:R:P125	R:R:W124	2.7	No	Yes	0	1	8
212	R:R:A93	R:R:Y97	2.67	No	Yes	0	6	7
213	R:R:F143	R:R:S186	2.64	Yes	No	0	6	8
214	R:R:R252	R:R:S255	2.64	No	No	0	5	4
215	R:R:F337	R:R:V83	2.62	No	No	0	8	8
216	R:R:F143	R:R:V189	2.62	Yes	No	0	6	5
217	R:R:R252	R:R:V160	2.62	No	No	0	5	8
218	R:R:S187	R:R:Y140	2.54	No	Yes	0	4	5
219	R:R:T63	R:R:Y119	2.5	No	Yes	0	5	4
220	R:R:F314	R:R:L318	2.44	No	No	0	5	8
221	R:R:L224	R:R:W221	2.28	No	No	0	3	1
222	R:R:G197	R:R:G198	2.11	No	No	0	4	4
223	R:R:F225	R:R:W221	2	No	No	0	4	1
224	L:L:?1	R:R:S211	1.92	Yes	No	0	0	4
225	R:R:G190	R:R:S136	1.86	No	No	0	6	5
226	R:R:G73	R:R:V72	1.84	No	Yes	0	8	5
227	R:R:G76	R:R:V75	1.84	No	No	0	7	4
228	R:R:G198	R:R:T199	1.82	No	Yes	0	4	4
229	R:R:A193	R:R:S136	1.71	No	No	0	5	5
230	R:R:C286	R:R:V285	1.71	No	No	0	8	6
231	R:R:A317	R:R:V65	1.7	No	No	0	5	5
232	R:R:G319	R:R:N322	1.7	No	Yes	0	7	9
233	R:R:C340	R:R:T88	1.69	No	No	0	6	6
234	R:R:I96	R:R:P172	1.69	Yes	No	0	5	2
235	R:R:C181	R:R:I177	1.64	No	No	0	4	3
236	R:R:V68	R:R:V72	1.6	No	Yes	0	5	5
237	R:R:V71	R:R:V72	1.6	No	Yes	0	5	5
238	R:R:V71	R:R:V75	1.6	No	No	0	5	4
239	R:R:A193	R:R:L135	1.58	No	Yes	0	5	7
240	R:R:A193	R:R:L212	1.58	No	No	0	5	4
241	R:R:A298	R:R:L224	1.58	No	No	0	4	3
242	R:R:T92	R:R:T94	1.57	No	No	0	7	8
243	R:R:I194	R:R:V195	1.54	Yes	No	0	4	4
244	R:R:H162	R:R:P163	1.53	No	No	0	6	8
245	R:R:I243	R:R:T247	1.52	No	No	0	5	4
246	R:R:I292	R:R:T288	1.52	No	No	0	5	5
247	R:R:K254	R:R:T273	1.5	No	No	0	4	6
248	R:R:L325	R:R:V72	1.49	No	Yes	0	6	5
249	R:R:L130	R:R:V129	1.49	No	No	0	5	1
250	R:R:L275	R:R:V279	1.49	No	No	0	8	8
251	R:R:L333	R:R:V278	1.49	No	No	0	7	5
252	R:R:N322	R:R:V282	1.48	Yes	No	0	9	7
253	R:R:L277	R:R:T273	1.47	No	No	0	4	6
254	R:R:I194	R:R:K132	1.45	Yes	No	0	4	6
255	R:R:L253	R:R:L259	1.38	No	No	0	8	3
256	R:R:L259	R:R:L269	1.38	No	No	0	3	6
257	R:R:L329	R:R:L333	1.38	No	No	0	8	7
258	R:R:D266	R:R:L269	1.36	No	No	0	3	6
259	R:R:E264	R:R:K265	1.35	No	No	0	3	4
260	R:R:F233	R:R:I232	1.26	No	No	0	4	5
261	R:R:F169	R:R:M151	1.24	No	Yes	0	4	6
262	R:R:N268	R:R:R267	1.21	No	No	0	5	4
263	R:R:D168	R:R:F169	1.19	No	No	0	4	4
264	R:R:D223	R:R:F214	1.19	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.82429	14	1	0
2	R:R:V72	1.6325	4	0	5
3	R:R:M90	6.5625	4	3	7
4	R:R:N95	4.3075	4	3	7
5	R:R:I96	4.752	5	0	5
6	R:R:Y97	5.66857	7	4	7
7	R:R:L101	7.63	4	2	9
8	R:R:D105	6.685	6	2	9
9	R:R:M112	9.2675	4	1	7
10	R:R:Y119	9.44	5	0	4
11	R:R:W124	5.81714	7	1	8
12	R:R:L135	3.76	4	1	7
13	R:R:Y140	6.37	5	5	5
14	R:R:F143	3.68667	6	0	6
15	R:R:M151	4.122	5	4	6
16	R:R:Y157	6.664	5	0	7
17	R:R:I194	4.175	4	0	4
18	R:R:T199	6.09	4	0	4
19	R:R:F231	7.02	4	1	5
20	R:R:F235	6.535	4	1	8
21	R:R:W287	8.36833	6	1	8
22	R:R:H291	7.6125	4	1	8
23	R:R:I294	8.3975	4	1	5
24	R:R:Y312	5.91	4	1	4
25	R:R:I316	4.445	4	1	5
26	R:R:Y320	11.685	4	1	6
27	R:R:N322	5.6475	4	0	9
28	R:R:P327	7.37	4	2	9
29	R:R:Y330	10.32	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y320	33.6937	11.27	Yes	Yes	1	0	6
2	R:R:M112	R:R:Y320	33.0304	23.95	Yes	Yes	1	7	6
3	R:R:M112	R:R:Y66	28.4937	4.79	Yes	No	0	7	6
4	R:R:Y313	R:R:Y66	23.7912	3.97	No	No	0	4	6
5	R:R:Y119	R:R:Y313	19.5795	21.84	Yes	No	0	4	4
6	L:L:?1	R:R:W287	70.1731	6.57	Yes	Yes	1	0	8
7	R:R:N322	R:R:W287	34.3636	14.69	Yes	Yes	0	9	8
8	R:R:C286	R:R:N322	30.2248	4.72	No	Yes	0	8	9
9	R:R:C286	R:R:T321	27.3993	3.38	No	No	0	8	5
10	R:R:T321	R:R:V69	25.9667	4.76	No	No	0	5	7
11	R:R:S324	R:R:V69	24.5208	3.23	No	No	0	7	7
12	R:R:G73	R:R:S324	21.5892	3.71	No	No	0	8	7
13	R:R:G73	R:R:V72	20.1035	1.84	No	Yes	0	8	5
14	R:R:I146	R:R:W287	98.8327	5.87	No	Yes	1	7	8
15	R:R:I146	R:R:P238	100	3.39	No	No	0	7	9
16	R:R:P238	R:R:T150	99.4561	3.5	No	No	0	9	7
17	R:R:I242	R:R:T150	98.8592	7.6	No	No	0	8	7
18	R:R:I242	R:R:S153	98.5408	6.19	No	No	0	8	9
19	R:R:S153	R:R:Y246	39.0927	6.36	No	No	0	9	8
20	R:R:R156	R:R:Y246	29.8866	8.23	No	No	0	9	8
21	R:R:R156	R:R:Y330	29.1172	10.29	No	Yes	0	9	9
22	R:R:M152	R:R:Y330	23.7713	8.38	No	Yes	0	8	9
23	R:R:L101	R:R:M152	23.2739	4.24	Yes	No	0	9	8
24	R:R:D105	R:R:L101	14.0811	9.5	Yes	Yes	2	9	9
25	R:R:C245	R:R:S153	62.466	3.44	No	No	0	7	9
26	R:R:C245	R:R:V154	51.3497	3.42	No	No	0	7	6
27	R:R:M151	R:R:V154	50.5538	6.09	Yes	No	0	6	6
28	R:R:M151	R:R:Y97	46.3686	5.99	Yes	Yes	4	6	7
29	R:R:A175	R:R:Y97	22.5045	4	No	Yes	0	7	7
30	R:R:A175	R:R:I96	21.1713	3.25	No	Yes	0	7	5
31	R:R:I96	R:R:M90	28.3412	8.75	Yes	Yes	0	5	7
32	R:R:N179	R:R:Y97	23.9504	8.14	No	Yes	0	7	7
33	R:R:I96	R:R:N179	21.2841	4.25	Yes	No	0	5	7
34	R:R:M90	R:R:N95	16.7872	4.21	Yes	Yes	3	7	7
35	L:L:?1	R:R:M142	10.1479	7.25	Yes	No	1	0	7
36	R:R:F143	R:R:M142	25.4759	3.73	Yes	No	0	6	7
37	R:R:F143	R:R:S186	27.7708	2.64	Yes	No	0	6	8
38	R:R:S186	R:R:T144	25.529	6.4	No	No	0	8	7
39	L:L:?1	R:R:V230	14.5851	3.82	Yes	No	0	0	5
40	R:R:F143	R:R:V230	10.6918	3.93	Yes	No	0	6	5
41	R:R:T144	R:R:Y140	21.0055	7.49	No	Yes	0	7	5
42	L:L:?1	R:R:L135	46.0635	4.43	Yes	Yes	1	0	7
43	R:R:C210	R:R:L135	33.2029	3.17	No	Yes	1	9	7
44	R:R:C210	R:R:W124	19.1019	13.06	No	Yes	1	9	8
45	R:R:C131	R:R:C210	12.8872	7.28	No	No	1	9	9
46	R:R:C131	R:R:T199	11.879	3.38	No	Yes	0	9	4
47	R:R:A193	R:R:L135	14.7377	1.58	No	Yes	0	5	7
48	R:R:A193	R:R:S136	10.8576	1.71	No	No	0	5	5
49	R:R:C245	R:R:Y157	23.3402	6.72	No	Yes	0	7	7
50	R:R:C161	R:R:Y157	13.5438	9.41	No	Yes	0	7	7
51	R:R:C161	R:R:R252	12.1045	2.79	No	No	0	7	5
52	L:L:?1	R:R:I294	15.5867	14.63	Yes	Yes	1	0	5
53	R:R:I294	R:R:K227	14.877	5.82	Yes	No	0	5	4
54	L:L:?1	R:R:H291	11.5474	4.94	Yes	Yes	1	0	8
55	R:R:F231	R:R:H291	12.204	9.05	Yes	Yes	1	5	8
56	R:R:F235	R:R:H291	16.4423	9.05	Yes	Yes	1	8	8
57	R:R:V276	R:R:Y246	18.5713	10.09	No	No	0	8	8
58	R:R:I250	R:R:V276	17.3576	6.14	No	No	0	5	8
59	R:R:I250	R:R:T273	15.9183	7.6	No	No	0	5	6
60	R:R:K254	R:R:T273	13.0331	1.5	No	No	0	4	6
61	R:R:K254	R:R:L269	11.6336	5.64	No	No	0	4	6
62	R:R:L325	R:R:V72	10.9107	1.49	No	Yes	0	6	5
63	R:R:H291	R:R:W287	18.5581	7.41	Yes	Yes	1	8	8
64	R:R:M142	R:R:W287	16.7009	4.65	No	Yes	1	7	8
65	R:R:M152	R:R:Y97	11.7928	5.99	No	Yes	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q115	16.2	1	Yes	No	0	7	0	1
L:L:?1	R:R:L135	4.43	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:D138	21.74	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y139	18.03	1	Yes	No	0	5	0	1
L:L:?1	R:R:M142	7.25	1	Yes	No	0	7	0	1
L:L:?1	R:R:V230	3.82	1	Yes	No	0	5	0	1
L:L:?1	R:R:W287	6.57	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I290	4.57	1	Yes	No	0	6	0	1
L:L:?1	R:R:H291	4.94	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I294	14.63	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y312	4.51	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:I316	3.66	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y320	11.27	1	Yes	Yes	0	6	0	1
R:R:D138	R:R:T111	7.23	0	No	No	6	7	1	2
R:R:M112	R:R:Y320	23.95	1	Yes	Yes	7	6	2	1
R:R:I316	R:R:Q115	6.86	1	Yes	No	5	7	1	1
R:R:Q115	R:R:Y320	7.89	1	No	Yes	7	6	1	1
R:R:L135	R:R:Y139	5.86	1	Yes	No	7	5	1	1
R:R:C210	R:R:L135	3.17	1	No	Yes	9	7	2	1
R:R:F143	R:R:M142	3.73	0	Yes	No	6	7	2	1
R:R:M142	R:R:W287	4.65	1	No	Yes	7	8	1	1
R:R:F143	R:R:V230	3.93	0	Yes	No	6	5	2	1
R:R:F283	R:R:I146	5.02	1	No	No	9	7	2	2
R:R:I146	R:R:W287	5.87	1	No	Yes	7	8	2	1
R:R:I294	R:R:K227	5.82	1	Yes	No	5	4	1	2
R:R:F231	R:R:F235	5.36	1	Yes	Yes	5	8	2	2
R:R:F231	R:R:H291	9.05	1	Yes	Yes	5	8	2	1
R:R:F235	R:R:H291	9.05	1	Yes	Yes	8	8	2	1
R:R:F283	R:R:W287	11.02	1	No	Yes	9	8	2	1
R:R:H291	R:R:W287	7.41	1	Yes	Yes	8	8	1	1
R:R:N322	R:R:W287	14.69	0	Yes	Yes	9	8	2	1
R:R:I290	R:R:I294	5.89	1	No	Yes	6	5	1	1
R:R:C315	R:R:I290	3.27	0	No	No	7	6	2	1
R:R:F293	R:R:Y312	8.25	0	No	Yes	5	4	2	1
R:R:I294	R:R:Y312	7.25	1	Yes	Yes	5	4	1	1
R:R:I316	R:R:Y312	3.63	1	Yes	Yes	5	4	1	1
R:R:I316	R:R:Y320	3.63	1	Yes	Yes	5	6	1	1
R:R:M226	R:R:V230	3.04	0	No	No	5	5	2	1
L:L:?1	R:R:S211	1.92	1	Yes	No	0	4	0	1
R:R:A193	R:R:L135	1.58	0	No	Yes	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9V6O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	239
Number of Links	264
Number of Hubs	29
Number of Links mediated by Hubs	122
Number of Communities	6
Number of Nodes involved in Communities	43
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	31394
Length Of Smallest Path	3
Average Path Length	13.0405
Length of Longest Path	28
Minimum Path Strength	1.215
Average Path Strength	6.03869
Maximum Path Strength	18.9867
Minimum Path Correlation	0.7
Average Path Correlation	0.918914
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	48.1378
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.9155
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IVB
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	IVB
Name	Nalfurafine
Synonyms	~{N}-[(4~{R},4~{a}~{S},7~{R},7~{a}~{R},12~{b}~{S})-3-(cyclopropylmethyl)-4~{a},9-bis(oxidanyl)-1,2,4,5,6,7,7~{a},13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-~{N}-methyl-propanamide
Identifier
Formula	C28 H32 N2 O5
Molecular Weight	476.564
SMILES
PubChem	6445230
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	5
Total Bonds	73
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41145
Sequence	>9V6O_nogp_Chain_R A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T K M K T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N S W P F G D V L C K I V S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H P V K A L D F R T P L K A K I I N I C I W L L S S S V G I S A I V L G G T K V I E C S L Q F W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V R L L S G S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F K R C L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DJH	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	2.9	2012-03-21	doi.org/10.1038/nature10939
	6B73	A	Peptide	Opioid	κ	Homo sapiens	MP1104	-	-	3.1	2018-01-17	doi.org/10.1016/j.cell.2017.12.011
	6VI4	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	-	3.3	2020-03-18	doi.org/10.1038/s41467-020-14889-7
	8F7W	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7W (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.19	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	7YIT	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	-	3.3	2023-04-12	doi.org/10.1038/s41467-023-37041-7
	8DZP	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Gi1/β1/γ2	2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZP (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.71	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-	Go/β1/γ2	2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZQ (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	momSalB	-		2.82	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gt3)/β1/γ2	2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZR (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.61	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-	chim(NtGi2-Gz)/β1/γ2	2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	8DZS (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GR89,696	-		2.65	2023-05-03	doi.org/10.1038/s41586-023-06030-7
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	9MQK	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	3.18	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQL	A	Peptide	Opioid	κ	Homo sapiens	Isoquinuclidine	-	-	2.96	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8FEG	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-	Gi1/β1/γ2	2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8FEG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	(DNCP)-β-Naloxamine	-		2.54	2023-12-06	doi.org/10.1038/s41467-023-43718-w
	8VVE	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVE (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	norBNI	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVF (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG	A	Peptide	Opioid	κ	Homo sapiens	GB18	-	Gi1/β1/γ2	3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	8VVG (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	GB18	-		3.3	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-	Gi1/β1/γ2	3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9D61 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	JDTic	-		3.58	2025-01-15	doi.org/10.1038/s41589-024-01812-0
	9V6O	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-	Gi1/β1/γ2	2.76	2025-11-19	10.1038/s41467-025-64882-1
	9V6O (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Nalfurafine	-		2.76	2025-11-19	10.1038/s41467-025-64882-1
	9W49	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-	Gi1/β1/γ2	2.9	2025-11-19	10.1038/s41467-025-64882-1
	9W49 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	U-50488H	-		2.9	2025-11-19	10.1038/s41467-025-64882-1
	9L60	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15	Gi1/β1/γ2	2.9	2025-12-31	To be published
	9L60 (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	MPAM-15		2.9	2025-12-31	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9V6O_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.