Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.02 5.335455
2G.H1.04 5.567924107
3G.S2.03 5.63458429
4G.S2.06 5.28433509
5G.S2.08 6.179555
6G.S3.03 7.138557
7G.S3.04 7.05267526
8G.S3.06 7.171525
9G.s3h2.03 4.87933529
10G.H2.06 6.977539
11G.H2.07 5.58048729
12G.h2s4.01 7.215529
13G.s4h3.04 5.748335158
14G.s4h3.05 8.040834159
15G.H3.01 4.01458409
16G.H3.06 5.48083406
17G.H3.09 6.2195119
18G.H3.17 6.29417625
19G.H3.18 6.00667409
20G.S5.04 4.9395119
21G.S5.05 4.563896109
22G.HG.04 6.747924159
23G.hgh4.02 5.293066187
24G.hgh4.05 5.51222607
25G.H4.03 3.08292404
26G.H4.10 7.909675186
27G.H4.15 5.15083408
28G.S6.02 4.790836197
29G.S6.05 4.28875404
30G.H5.03 5.616254108
31G.H5.05 3.1875455
32G.H5.08 6.30417458
33G.H5.20 5.05667409
34G.H5.26 5.32417405
35b.b1x3 5.54542497
36b.l1x3 10.7321409
37b.l1x6 11.9192429
38b.b2x1 7.32567528
39b.b2x5 7.21028667
40b.b3x3 4.90708408
41b.l3x2 4.75875409
42b.b4x3 5.315407
43b.b4x6 11.8347569
44b.b5x2 5.86507
45b.b5x3 6.5425669
46b.b5x5 5.594174165
47b.b5x7 6.2425407
48b.l5x1 4.95042408
49b.l5x5 7.06452729
50b.b6x5 4.845506
51b.l7x2 4.536529
52b.b8x3 3.51708406
53b.b8x4 5.786506
54b.l8x3 3.569584213
55b.l8x5 3.585424213
56b.b9x3 5.52708406
57b.l9x3 7.30933539
58b.l9x6 5.23929738
59b.b10x3 3.78375408
60b.b10x5 4.5875609
61b.l10x3 5.996254206
62b.l11x2 7.49567539
63b.b12x6 7.96214738
64b.b13x7 9.113587
65b.l13x3 9.38542409
66b.l13x6 5.56767539
67b.b14x3 5.29542485
68b.b15x1 7.60133589
69b.l15x1 5.20375437
70b.l15x2 5.27917409
71b.b16x4 8.95433586
72b.b16x5 4.41208405
73b.b16x6 10.201588
74b.b17x4 5.376254225
75b.l17x3 8.21238749
76b.l17x6 6.59933539
77b.b18x3 5.45542448
78b.b18x5 6.00792445
79b.l18x1 6.59976776
80b.l18x2 5.9375477
81b.b19x2 7.69472646
82b.b19x4 7.17917448
83b.l19x2 6.89833549
84b.b20x4 9.26472648
85b.b20x6 7.24917646
86b.b20x7 4.939509
87b.l20x2 8.24208479
88b.b21x3 7.16917446
89b.b21x5 4.16042404
90b.b21x7 6.63167505
91b.l21x2 5.29375404
92b.b22x5 6.05033577
93b.b23x6 6.874726137
94b.l23x1 7.98333426
95b.b24x2 4.487084135
96b.b24x4 5.632335136
97b.b24x6 6.4354138
98b.l24x2 4.73292406
99b.l25x3 7.275335129
100b.l25x4 5.52917405
101b.l25x6 11.8533428
102b.l27x1 11.475729
103b.l27x2 5.6035129
104b.b28x4 6.744584126
105b.b28x6 8.3575129
106b.b28x7 7.52875499
107g.h1x11 2.70958409
108g.l1x4 4.52208408
109g.h2x11 9.9625476
110g.ctx3 6.47767509
111g.ctx6 3.0375406
112g.ctx14 5.73625499
113g.ctx16 4.43595798
1141x35 6.07125404
1151x50 5.69375409
1161x52 3.09958407
1171x53 5.1555239
1182x42 4.65508
1192x50 5.51708419
1202x51 3.0925407
1212x57 4.7375407
122E1x50 5.95767518
123E1x52 7.1575406
1243x49 7.076674149
1253x50 5.95467509
126I2x56 5.220335145
127I2x57 6.1835147
1284x41 5.055424147
1294x61 7.122517
130E2 14.18861213
131E2x50 6.08417419
132E2x52 7.79375415
1335x39 6.66767518
1345x50 2.80875409
1355x58 7.12292409
1366x48 6.22056618
1376x50 1.89409
1386x52 4.48042417
139E3 9.14018913
1407x34 7.95417415
1417x37 3.145416
1427x38 5.36708416
1437x42 7.88967517
1447x49 4.99133519
1457x52 3.61375419
1467x53 4.82722619
1477x55 3.67417406
1488x52 1.9475405
149Lig 14.48241710
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x1 b.b4x7 20.5562.715NoNo058
2b.b3x1 b.b6x5 19.5975.27667NoYes056
3b.b3x6 b.l1x3 11.234410.4617NoYes099
4b.b3x6 b.l3x2 10.21567.85333NoYes099
5b.b4x7 b.l2x5 25.393814.29NoNo085
6b.l2x5 b.l4x2 25.861118.8633NoNo054
7b.l4x2 g.ctx16 26.29866.01667NoYes048
8b.b28x7 g.ctx16 51.25964.02667YesYes998
9b.b28x7 b.lhb1x11 63.23873.27YesNo094
10b.b25x7 b.lhb1x11 63.65425.65333NoNo074
11b.b25x7 b.b28x6 75.290315.1867NoYes079
12b.b27x3 b.b28x6 37.94959.90333NoYes089
13b.b27x3 b.l25x3 38.13427.75667NoYes089
14b.l25x3 b.l27x2 77.06333.99YesYes1299
15b.l25x4 b.l27x2 1006.43YesYes059
16I1x49 b.l25x4 99.320112.11NoYes065
171x60 I1x49 98.70357.56333NoNo066
181x60 8x57 98.52052.925NoNo066
191x56 8x57 98.42964.23NoNo086
201x56 8x50 98.33736.12NoNo089
217x54 8x50 94.88696.74833NoNo2389
222x43 7x54 96.58515.555NoNo088
232x43 7x53 96.48314.69NoYes089
243x50 7x53 48.6096.51333YesYes099
253x50 G.H5.23 11.73923.825YesNo094
26G.H5.23 I2x57 10.8163.75833NoYes1447
27b.b28x4 b.b28x6 38.1334.44667YesYes1269
28b.b28x4 b.l25x3 38.60316.76833YesYes1269
29b.l25x5 b.l27x2 89.63443.81667NoYes079
30b.l25x5 b.l27x1 89.54266.78NoYes079
31b.l3x1 b.l5x5 11.05125.84NoYes299
32b.b2x1 b.l27x1 75.97827.555YesYes289
333x50 G.H5.25 31.68426.88167YesNo097
34G.H5.20 G.H5.25 30.03333.46YesNo097
35G.H5.16 G.H5.20 25.27882.58667NoYes069
36G.H5.16 I2x50 24.99355.32833NoNo068
37G.H5.15 I2x50 24.70773.385NoNo078
38G.H5.15 I2x54 24.42145.63667NoNo076
39G.S1.02 I2x54 24.13464.955YesNo056
40G.S1.02 G.S3.03 19.57777.05333YesYes557
41G.S2.06 G.S3.03 14.784111.7883YesYes097
42G.H2.04 G.H3.08 32.25315.66667NoNo099
43G.H2.04 G.H2.07 32.82055.16667NoYes099
44G.H2.07 b.l7x2 69.93394.93667YesYes299
45G.H2.10 b.l7x2 70.56564.23333NoYes079
46G.H2.10 b.b2x1 70.71266.05NoYes078
47G.H4.15 G.S5.04 18.7864.87333YesYes089
48G.S4.04 G.S5.04 26.56113.44833NoYes1199
49G.H3.08 G.S4.04 31.8197.10667NoNo099
50G.H2.02 G.H2.07 56.34594.11667NoYes089
51G.H2.02 b.l9x6 56.1034.87833NoYes088
52G.H2.06 b.l9x6 30.05873.97833YesYes398
53G.H2.06 b.l17x6 28.859810.6YesYes399
54G.H3.06 G.H4.15 13.18524.97167YesYes068
55b.l25x6 b.l27x1 20.437319.8233YesYes289
56b.l17x5 b.l17x6 29.41552.45167NoYes069
57b.l17x5 b.l19x2 29.11013.67833NoYes069
58b.l17x3 b.l19x2 24.8735.04YesYes499
59b.b20x6 b.l17x3 21.01053.58YesYes469
60b.b17x7 b.b20x6 17.546910.895NoYes486
61b.b17x5 b.b17x7 17.35678.2NoNo078
62b.b17x5 b.b21x1 13.45618.70167NoNo077
63b.1x19 b.b21x1 11.809810.1267NoNo067
64b.1x15 b.1x19 10.1514.38667NoNo076
65b.l26x5 g.ctx15 10.21285.87167NoNo059
66g.ctx3 g.ctx6 10.49745.88167YesYes096
67b.b22x5 b.b23x2 11.25411.57YesNo076
68b.b21x7 b.b23x2 11.73285.08167YesNo056
69b.b1x6 b.b4x6 19.938520.5033NoYes099
70b.b1x6 b.b28x5 20.92784.04167NoNo095
71b.b10x1 b.l9x6 14.04615.51NoYes098
72b.b10x1 b.b11x5 13.7363.26NoNo096
73b.l11x1 b.l9x6 14.62795.07NoYes398
74b.b11x6 b.l11x1 15.39823.40167NoNo399
75b.b11x6 b.l9x3 12.268913.0167NoYes399
76b.b12x6 b.l9x3 10.61865.11167YesYes389
77b.l23x1 b.l25x6 26.754619.2583YesYes268
78b.l21x7 b.l23x1 26.09435.18667NoYes056
79b.b23x6 b.l21x7 24.32725.15167YesNo075
80b.b21x7 b.b24x6 18.932312.22YesYes058
81b.b23x6 b.b24x6 19.42376.10833YesYes1378
82b.b24x3 b.b25x7 11.8475.555NoNo057
83b.b24x3 b.b26x3 11.3753.965NoNo056
84b.b23x3 b.b26x3 10.44034.84667NoNo076
853x36 Lig 22.06856.73NoYes170
863x36 6x48 22.29385.71833NoYes178
876x48 7x45 58.9918.855YesNo189
887x45 7x49 59.71983.47667NoYes199
897x49 7x53 66.82843.48667YesYes199
906x52 Lig 22.68814.63333YesYes170
916x48 6x52 24.42786.72667YesYes187
926x48 7x41 12.70555.35333YesNo087
93E2 Lig 12.725116.1717YesYes130
94b.b28x5 g.ctx16 22.42073.76833NoYes058
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x326.750NoNo7721
2x567x4210.08170NoYes7722
2x607x383.886671NoYes7621
2x607x427.941671NoYes7722
2x63E1x504.091671NoYes5812
2x63Lig4.431671NoYes5010
2x64Lig4.953330NoYes6010
2x67E23.590NoYes4321
3x25E1x506.0551NoYes9822
E1x50E2x508.8451YesYes8921
3x22E24.631671NoYes4321
3x25E2x506.976671NoYes9921
3x283x323.278330NoNo6721
3x294x613.571670NoYes6721
3x294x654.796670NoNo6622
3x32Lig6.571NoYes7010
3x366x485.718331NoYes7812
3x36Lig6.731NoYes7010
4x574x613.591670NoYes8721
4x61E2x528.691671YesYes7511
4x61Lig15.89671YesYes7010
4x64E214.0051NoYes5321
4x65E2x525.403330NoYes6521
E2E247.66331YesYes3311
E2E2x503.356671YesYes3911
E2E2x5111.53171YesNo3411
E2Lig16.17171YesYes3010
E2x50Lig5.158331YesYes9010
E2x51Lig12.05831NoYes4010
E2E2x524.103331YesYes3511
E2x52Lig12.97671YesYes5010
5x35E27.731671NoYes4321
5x39E25.981671YesYes8321
5x4616x523.368330NoYes7721
6x486x526.726671YesYes8721
6x52Lig4.633331YesYes7010
6x55Lig11.23830NoYes7010
6x576x616.698331NoNo5422
6x57E315.36171NoYes5321
6x58E311.24671NoYes4311
6x58Lig13.75671NoYes4010
6x61E33.673331NoYes4321
E3E37.0051YesYes3311
E3Lig29.98831YesYes3010
7x33E33.828331NoYes4321
7x347x374.6651YesYes5612
7x347x384.0751YesYes5611
7x34Lig21.72671YesYes5010
7x387x429.631YesYes6712
4x615x393.858331YesYes7812
5x36E23.833331NoYes5321
7x38Lig3.876671YesYes6010
5x446x523.193330NoYes7721
2x622x632.5150NoNo5521
6x62E32.2950NoYes0321
7x31E31.858330NoYes3321
6x547x341.351NoYes5521
6x547x371.351NoYes5622

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
87.50Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
87.50Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
87.50Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
83.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
76.47Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
73.68Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
73.68Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
72.22Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
70.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
68.42Single7F8XNN90567F8X-CCKA-NN9056
68.42Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
68.18Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
66.67Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
64.71Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
63.16Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
61.90Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
57.14Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
55.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
54.55Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
54.17Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
54.17Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
54.17Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
52.63Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
52.17Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
52.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
52.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
52.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
52.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
52.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
52.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
50.00Single3QAKUK-4320973QAK-A2A-UK-432097
50.00Single5N2SPSB365N2S-A1-PSB36
50.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
50.00Single7EZCUKA7EZC-A2A-UKA
50.00Single7F8ULintitript7F8U-CCKA-Lintitript
50.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
50.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
48.15Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
48.15Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
48.15Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
48.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
47.83Single5WF5UK-4320975WF5-A2A-UK-432097
47.83Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
47.83Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.83Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
47.83Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
47.83Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
47.62Single4UG2CGS216804UG2-A2A-CGS21680
47.62Single5WF6UK-4320975WF6-A2A-UK-432097
47.62Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
47.62Single7XN9L-054,5227XN9-SST2-L-054,522
47.62Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
47.62Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
47.37Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
47.06Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
46.15Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
45.83Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
45.45Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
45.45Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
45.00Single6MXTSalmeterol6MXT-β2-Salmeterol
45.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
45.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
45.00Single8JJLOlodaterol8JJL-β2-Olodaterol
45.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
44.44Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
44.44Single8CU6LJ-45178CU6-A2A-LJ-4517
44.44Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
44.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
44.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
44.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.48Single7SK5CXCL127SK5-ACKR3-CXCL12
43.48Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
43.48Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
43.48Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
43.48Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
42.86Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
42.86Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
42.86Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
42.86Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
42.86Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
42.86Consensusbombesin_onOrthosteric Ligandbb2_on
42.86Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
42.86Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
42.86Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
42.31Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
42.11Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
42.11Single5N2RPSB-365N2R-A2A-PSB-36-Na
42.11Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
42.11Single7C61Ergotamine7C61-5-HT1B-Ergotamine
42.11Single8QOTNanobody-E8QOT-μ-Nanobody-E
42.11Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
42.11Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Consensusadenosine_offOrthosteric Liganda1_off a2_off
41.67Single6PT2KGCHM076PT2-δ-KGCHM07
41.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
41.67Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
41.67Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
41.67Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
41.18Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
41.18Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
41.18Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
41.18Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
41.18Single8GNGIstradefylline8GNG-A2A-Istradefylline
40.91Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.91Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.91Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.74Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
40.74Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
40.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
40.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
40.00Single7PX4PSB-21137PX4-A2A-PSB-2113
40.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
40.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
40.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
40.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
40.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
40.00Consensusa2_onOrthosteric Liganda2b_on
40.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
40.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
40.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
40.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
40.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
40.00Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
40.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
39.29Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
39.13Single4IARErgotamine4IAR-5-HT1B-Ergotamine
39.13Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
39.13Single4XT1Fractalkine4XT1-US28-Fractalkine
39.13Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
39.13Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
39.13Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single8WDTphotoNECA8WDT-A2A-photoNECA
39.13Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.13Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
39.13Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
39.13Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
39.13Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
39.13Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
39.13Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
39.13Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
39.13Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
38.89Single5IU7Q274563465IU7-A2A-Q27456346-Na
38.89Single5IUBQ274563445IUB-A2A-Q27456344-Na
38.89Single5JTBZM-2413855JTB-A2A-ZM-241385
38.89Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
38.89Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
38.89Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
38.89Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
38.89Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
38.89Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
38.89Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
38.89Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
38.89Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
38.89Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
38.89Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
38.89Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
38.89Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
38.89Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
38.89Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
38.89Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
38.89Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
38.89Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
38.89Consensusa2_offOrthosteric Liganda2a_off
38.89Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
38.89Consensushca_onOrthosteric Ligandhca2_on
38.71Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
38.46Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.46Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
38.46Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
38.46Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
38.46Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
38.10Single4RWADIPP-NH24RWA-δ-DIPP-NH2
38.10Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
38.10Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
38.10Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.10Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
38.10Single8JWY2-1188JWY-A2A-2-118
38.10Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.10Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
38.10Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
38.10Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
38.10Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
38.10Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
37.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
37.50Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
37.50Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
37.50Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
37.50Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
37.50Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.04Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.84Single3EMLZM-2413853EML-A2A-ZM-241385
36.84Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
36.84Single5DHHSB-6121115DHH-NOP-SB-612111
36.84Single5IU8Q274563475IU8-A2A-Q27456347-Na
36.84Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
36.84Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
36.84Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
36.84Single5UIGCmpd-15UIG-A2A-Cmpd-1
36.84Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
36.84Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
36.84Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
36.84Single6PS1Timolol6PS1-β2-Timolol
36.84Single6S0LZM-2413856S0L-A2A-ZM-241385
36.84Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
36.84Single7PYRPSB-21157PYR-A2A-PSB-2115
36.84Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
36.84Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
36.84Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.84Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.84Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
36.84Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
36.84Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
36.84Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.84Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
36.84Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.84Single8K5DGSK2560738K5D-HCA2-GSK256073
36.84Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
36.84Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
36.84Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
36.84Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
36.84Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
36.84Single9CHXS-Carazolol9CHX-β2-S-Carazolol
36.84Consensusa3_onOrthosteric Liganda3a_on
36.84Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
36.84Consensuscck_offOrthosteric Ligandccka_off
36.84Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
36.84Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.84Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.84Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.84Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.84Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
36.84Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
36.84Consensushca_on_gpOrthosteric Ligandhca2_on_gp
36.36Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
36.36Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
36.36Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
36.36Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
36.36Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
36.36Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
36.36Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
36.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
36.00Consensusangiotensin_onOrthosteric Ligandat1_on
36.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
35.71Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
35.71Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
35.29Single3OE9IT1t3OE9-CXCR4-IT1t
35.29Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
35.29Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
35.29Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
35.29Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
35.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
35.29Single8K5BNiacin8K5B-HCA2-Niacin
35.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
35.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
35.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
35.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
35.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
35.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
35.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
35.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
35.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
35.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
35.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
35.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
35.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
35.00Single7W41PD1762527W41-BB2-PD176252
35.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
35.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
35.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
35.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
35.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
35.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
35.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
35.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
35.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
35.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
35.00Consensusbombesin_offOrthosteric Ligandbb2_off
35.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
35.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
35.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
34.78Single3NY9ICI118-5513NY9-β2-ICI118-551
34.78Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
34.78Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
34.78Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
34.78Single8QJ2pN1628QJ2-MC4-pN162-Gs
34.78Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
34.78Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single6JODAngiotensin II6JOD-AT2-Angiotensin II
34.62Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
34.62Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.62Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
34.62Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
34.62Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
34.62Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
34.62Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.62Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.62Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
34.62Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
34.48Single6IGLIRL16206IGL-ETB-IRL1620
34.48Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single3ODUIT1t3ODU-CXCR4-IT1t
33.33Single3P0GBI1671073P0G-β2-BI167107
33.33Single3PWHZM-2413853PWH-A2A-ZM-241385
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
33.33Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
33.33Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
33.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6WGTLSD6WGT-5-HT2A-LSD
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
33.33Single7F8YDevazepide7F8Y-CCKA-Devazepide
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
33.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
33.33Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
33.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
33.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
33.33Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
33.33Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
33.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
33.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
33.33Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
33.33Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
33.33Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
33.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
33.33Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
33.33Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
33.33Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
33.33Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
33.33Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single8ZRTET-18ZRT-ETB-ET-1
33.33Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
33.33Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
33.33Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
33.33Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
33.33Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
33.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
33.33Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
32.26Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.26Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
32.26Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
32.14Single4XT3Fractalkine4XT3-US28-Fractalkine
32.14Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
32.14Single6FJ3PTH6FJ3-PTH1-PTH
32.14Single7SK3CXCL127SK3-ACKR3-CXCL12
32.14Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
32.14Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.14Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
32.14Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
32.14Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
32.14Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.14Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
32.14Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
32.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
32.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
32.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
32.00Single7XNACYN1548067XNA-SST2-CYN154806
32.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
32.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
32.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
32.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
32.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
32.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
32.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.82Single4AMIBucindolol4AMI-β1-Bucindolol
31.82Single4XEENeurotensin4XEE-NTS1-Neurotensin
31.82Single4XESNeurotensin4XES-NTS1-Neurotensin
31.82Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
31.82Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.82Single6OS2TRV0266OS2-AT1-TRV026
31.82Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
31.82Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
31.82Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.82Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
31.82Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
31.82Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
31.82Single8JJ8Formoterol8JJ8-β2-Formoterol
31.82Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
31.82Single8JWZAB9288JWZ-A2A-AB928-Na
31.82Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
31.82Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
31.82Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
31.82Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
31.82Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
31.82Consensusalpha1_offOrthosteric Ligandalpha1a_off
31.82Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
31.82Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
31.82Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
31.82Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
31.82Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
31.82Consensusorexin_onOrthosteric Ligandox2_on
31.58Single2YDOAdenosine2YDO-A2A-Adenosine
31.58Single3REYXAC3REY-A2A-XAC
31.58Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
31.58Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
31.58Single5UVIZM-2413855UVI-A2A-ZM-241385
31.58Single6AQFZM-2413856AQF-A2A-ZM-241385
31.58Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
31.58Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.58Single6MH8ZM-2413856MH8-A2A-ZM-241385
31.58Single6PS0S-Carazolol6PS0-β2-S-Carazolol
31.58Single6PS4ICI118-5516PS4-β2-ICI118-551
31.58Single6PS5S-Propranolol6PS5-β2-S-Propranolol
31.58Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
31.58Single7AROLUF58337ARO-A2A-LUF5833-Na
31.58Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.58Single7T32ZM-2413857T32-A2A-ZM-241385
31.58Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
31.58Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
31.58Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
31.58Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
31.58Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
31.58Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
31.58Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
31.58Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
31.58Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
31.58Single8IHKAcifran8IHK-HCA3-Acifran
31.58Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
31.58Single8K5CAcipimox8K5C-HCA2-Acipimox
31.58Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
31.58Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
31.58Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
31.58Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
31.58Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
31.58Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
31.58Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
31.58Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
31.58Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
31.58Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
31.25Single8A2OTheophylline8A2O-A2A-Theophylline-Na
31.03Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
31.03Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
30.77Single3OE0CVX153OE0-CXCR4-CVX15
30.77Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
30.77Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
30.77Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
30.77Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.77Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.77Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
30.77Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.43Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
30.43Single4BUONeurotensin4BUO-NTS1-Neurotensin
30.43Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
30.43Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
30.43Single6H7LDobutamine6H7L-β1-Dobutamine
30.43Single6IBLArformoterol6IBL-β1-Arformoterol
30.43Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
30.43Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
30.43Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
30.43Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7UM4AS26747237UM4-5-HT5A-AS2674723
30.43Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
30.43Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
30.43Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
30.43Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
30.43Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
30.43Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
30.43Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
30.43Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.43Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.43Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.43Consensuschemerin_onOrthosteric Ligandcml1_on
30.43Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
30.43Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
30.43Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
30.43Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
30.43Consensusprostanoid_offOrthosteric Ligandep_off dp_off
30.00Single2Y02Carmoterol2Y02-β1-Carmoterol
30.00Single3NY8ICI118-5513NY8-β2-ICI118-551
30.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
30.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
30.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
30.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
30.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
30.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
30.00Single5UENDU1725UEN-A1-DU172
30.00Single6D27CAY104716D27-DP2-CAY10471
30.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
30.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
30.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
30.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
30.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
30.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
30.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
30.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
30.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
30.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
30.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
30.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
30.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
30.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
30.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
30.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
30.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
30.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
30.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
30.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
30.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
30.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
30.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
30.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
30.00Single8JJOAlprenolol8JJO-β2-Alprenolol
30.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
30.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
30.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
30.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
30.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
30.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
30.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
30.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
30.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
30.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
30.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
30.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
30.00Consensusbradykinin_onOrthosteric Ligandbk2_on
30.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
30.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
30.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
30.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
30.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
30.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
30.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
30.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
30.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
30.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
30.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
29.63Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
29.63Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
29.63Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
29.63Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
29.63Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
29.63Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
29.41Single3OE6IT1t3OE6-CXCR4-IT1t
29.41Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
29.41Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
29.41Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
29.41Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
29.17Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
29.17Single6PT3DPI-2876PT3-δ-DPI-287
29.17Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
29.17Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
29.17Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
29.17Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
29.17Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
29.17Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
29.17Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
29.17Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
29.17Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
29.17Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
29.17Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
29.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
29.03Single6IGKEndothelin-36IGK-ETB-Endothelin-3
29.03Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Single2RH1S-Carazolol2RH1-β2-S-Carazolol
28.57Single2YCWS-Carazolol2YCW-β1-S-Carazolol
28.57Single5C1MBU725C1M-μ-BU72
28.57Single5D6LS-Carazolol5D6L-β2-S-Carazolol
28.57Single5JQHS-Carazolol5JQH-β2-S-Carazolol
28.57Single5TVNLSD5TVN-5-HT2B-LSD
28.57Single5WQCEMPA5WQC-OX2-EMPA
28.57Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
28.57Single6D26Fevipiprant6D26-DP2-Fevipiprant
28.57Single6E67BI1671076E67-β2-BI167107-Gs (fused)
28.57Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
28.57Single6LUQHaloperidol6LUQ-D2-Haloperidol
28.57Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
28.57Single6PS6Timolol6PS6-β2-Timolol
28.57Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
28.57Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
28.57Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
28.57Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.57Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
28.57Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
28.57Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
28.57Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
28.57Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
28.57Single8S4DCMF-0198S4D-Apelin-CMF-019
28.57Single8TF5Oleic acid8TF5-GPR6-Oleic acid
28.57Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
28.57Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
28.57Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
28.57Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
28.57Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
28.57Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
28.57Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
28.57Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
28.57Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
28.57Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
28.57Consensusamine_offonOrthosteric Ligandamine_off amine_on
28.57Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
28.57Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
28.57Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
28.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
28.57Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.57Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.57Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
28.57Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
28.57Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
28.57Consensusdp_offOrthosteric Liganddp2_off
28.57Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.57Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.57Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
28.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.57Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.57Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
28.57Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Consensustrace-amine_onOrthosteric Ligandta1_on
28.12Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
28.12Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
28.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
28.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
28.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
28.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
28.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
28.00Single8WKYPG-9348WKY-MC4-PG-934
28.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Single8XWNCXCL88XWN-CXCR2-CXCL8
28.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
28.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
28.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
28.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
28.00Consensussomatostatin_offOrthosteric Ligandsst2_off
27.78Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
27.78Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
27.78Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
27.78Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
27.78Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
27.78Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
27.78Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
27.78Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
27.78Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
27.78Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
27.78Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
27.78Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
27.78Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
27.78Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
27.78Consensusgq_nucleotideOrthosteric Ligandgq_p2y
27.78Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
27.59Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
27.59Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
27.27Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
27.27Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
27.27Single4BV0Neurotensin4BV0-NTS1-Neurotensin
27.27Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
27.27Single5D5AS-Carazolol5D5A-β2-S-Carazolol
27.27Single5D5BS-Carazolol5D5B-β2-S-Carazolol
27.27Single5XR8AM8415XR8-CB1-AM841
27.27Single5XRAAM115425XRA-CB1-AM11542
27.27Single6H7JIsoprenaline6H7J-β1-Isoprenaline
27.27Single6J20Aprepitant6J20-NK1-Aprepitant
27.27Single6J21Aprepitant6J21-NK1-Aprepitant
27.27Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
27.27Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
27.27Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
27.27Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
27.27Single6TQ7SB-3348676TQ7-OX1-SB-334867
27.27Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
27.27Single7B6WCyclazosin7B6W-α1b-Cyclazosin
27.27Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
27.27Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
27.27Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
27.27Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
27.27Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
27.27Single7TUYGSK682753A7TUY-GPR183-GSK682753A
27.27Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
27.27Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
27.27Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
27.27Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
27.27Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
27.27Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
27.27Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
27.27Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
27.27Single8E0GBU728E0G-μ-BU72
27.27Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
27.27Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
27.27Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
27.27Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
27.27Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
27.27Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
27.27Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
27.27Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
27.27Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
27.27Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
27.27Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
27.27Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
27.27Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
27.27Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.27Consensusneurotensin_onOrthosteric Ligandnts1_on
27.27Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.27Consensusrelaxin_onOrthosteric Ligandrxfp4_on
27.27Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
27.27Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
26.92Single6HLOAprepitant6HLO-NK1-Aprepitant
26.92Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.92Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
26.92Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
26.92Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
26.92Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
26.92Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
26.92Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.92Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
26.92Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.92Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.92Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
26.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
26.67Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
26.67Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
26.32Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
26.32Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
26.32Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.32Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
26.32Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
26.32Single6ME2Ramelteon6ME2-MT1-Ramelteon
26.32Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
26.32Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
26.32Single6TODEMPA6TOD-OX1-EMPA-Na
26.32Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
26.32Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
26.32Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
26.32Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
26.32Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
26.32Single7XRRLemborexant7XRR-OX2-Lemborexant
26.32Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
26.32Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
26.32Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
26.32Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
26.32Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
26.32Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
26.32Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
26.32Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
26.32Single8IWESpermidine8IWE-TA9-Spermidine
26.32Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
26.32Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
26.32Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
26.32Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
26.32Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.32Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
26.32Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
26.32Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
26.32Consensusorexin_offOrthosteric Ligandox2_off ox1_off
26.32Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
26.32Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.32Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
26.09Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
26.09Single3D4STimolol3D4S-β2-Timolol
26.09Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
26.09Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
26.09Single4LDEBI1671074LDE-β2-BI167107
26.09Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
26.09Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
26.09Single6A93Risperidone6A93-5-HT2A-Risperidone
26.09Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
26.09Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
26.09Single6YVRNTS8-136YVR-NTS1-NTS8-13
26.09Single7DFPSpiperone7DFP-D2-Spiperone
26.09Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
26.09Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
26.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
26.09Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.09Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
26.09Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
26.09Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
26.09Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
26.09Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
26.09Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
26.09Single7YITNalfurafine7YIT-κ-Nalfurafine
26.09Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
26.09Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
26.09Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
26.09Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
26.09Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
26.09Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
26.09Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
26.09Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.09Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.09Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
26.09Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
26.09Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
26.09Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
26.09Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.09Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.09Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
26.09Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
26.09Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
26.09Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
26.09Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.09Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.09Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
26.09Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
26.09Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
26.09Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
26.09Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.09Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.09Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.09Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.93Single6W25SHU91196W25-MC4-SHU9119-Ca
25.93Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
25.93Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.93Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
25.93Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
25.93Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.93Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.93Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.81Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.81Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
25.81Single8IY6Endothelin-18IY6-ETB-Endothelin-1
25.81Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
25.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
25.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
25.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
25.00Single6KUXRS-799486KUX-α2a-RS-79948
25.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6TPGEMPA6TPG-OX2-EMPA
25.00Single6TPNHTL66416TPN-OX2-HTL6641
25.00Single6V9SGTPL114036V9S-OX1-GTPL11403
25.00Single6VI4JDTic6VI4-κ-JDTic
25.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
25.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
25.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
25.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
25.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
25.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
25.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
25.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7UL3Famotidine7UL3-H2-Famotidine
25.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
25.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
25.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
25.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
25.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
25.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
25.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
25.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
25.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
25.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
25.00Single8PWNTheophylline8PWN-A2A-Theophylline
25.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
25.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
25.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
25.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
25.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
25.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XVUCXCL28XVU-CXCR2-CXCL2
25.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
25.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
25.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
25.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
25.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
25.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
25.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
25.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
25.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
25.00Consensusendothelin_offOrthosteric Ligandetb_off
25.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
25.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.00Consensusgrh_offOrthosteric Ligandgnrh1_off
25.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
25.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
25.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
25.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
25.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
24.39Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
24.24Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
24.14Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
24.14Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
24.14Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
24.14Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
24.14Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
24.14Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
24.14Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
24.14Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
24.14Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
24.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
24.00Single5ZTYAM102575ZTY-CB2-AM10257
24.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
24.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
24.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
24.00Single8X5YAstemizole8X5Y-H1-Astemizole
24.00Single8XQJJN2418XQJ-Apelin-JN241
24.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
24.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
24.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
24.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
24.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
24.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
24.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
24.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
23.81Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
23.81Single2Y04Salbutamol2Y04-β1-Salbutamol
23.81Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
23.81Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
23.81Single4EJ4Naltrindole4EJ4-δ-Naltrindole
23.81Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
23.81Single4QIMANTA XV4QIM-SMO-ANTA XV
23.81Single4QKX35V4QKX-β2-35V
23.81Single4YAYZD-71554YAY-AT1-ZD-7155
23.81Single5DHGC-355DHG-NOP-C-35
23.81Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.81Single6DRXLisuride6DRX-5-HT2B-Lisuride
23.81Single6H7MSalbutamol6H7M-β1-Salbutamol
23.81Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.81Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
23.81Single6TOTLemborexant6TOT-OX1-Lemborexant
23.81Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
23.81Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
23.81Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
23.81Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
23.81Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
23.81Single7UL4Alvimopan7UL4-μ-Alvimopan
23.81Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
23.81Single7V3ZCP559407V3Z-CB1-CP55940
23.81Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
23.81Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
23.81Single7WC7Lisuride7WC7-5-HT2A-Lisuride
23.81Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
23.81Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
23.81Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
23.81Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
23.81Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
23.81Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
23.81Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
23.81Single8JXRLSD8JXR-D1-LSD
23.81Single8RLNLUF58348RLN-A2A-LUF5834
23.81Single8T1WCVN4248T1W-GPR6-CVN424
23.81Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
23.81Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
23.81Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
23.81Single8X63Mepyramine8X63-H1-Mepyramine
23.81Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
23.81Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
23.81Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
23.81Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
23.81Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
23.81Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
23.81Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
23.81Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
23.81Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.81Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.81Consensusalpha2_onOrthosteric Ligandalpha2b_on
23.81Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
23.81Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.81Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.81Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
23.81Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
23.81Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
23.81Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
23.81Consensushistamine_offOrthosteric Ligandh1_off
23.53Single3RFMCaffeine3RFM-A2A-Caffeine
23.53Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.53Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single9CHUNoradrenaline9CHU-β2-Noradrenaline
23.33Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
23.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
23.33Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
23.33Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
23.08Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
23.08Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
23.08Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
23.08Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
23.08Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
23.08Consensuslpl_onOrthosteric Ligands1p_on lpa_on
23.08Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
22.73Single2Y00Dobutamine2Y00-β1-Dobutamine
22.73Single2Y03Isoprenaline2Y03-β1-Isoprenaline
22.73Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
22.73Single5WIUNemonapride5WIU-D4-Nemonapride
22.73Single5WIVNemonapride5WIV-D4-Nemonapride-Na
22.73Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
22.73Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.73Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
22.73Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
22.73Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
22.73Single6TP6Filorexant6TP6-OX1-Filorexant
22.73Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
22.73Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
22.73Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
22.73Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
22.73Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
22.73Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
22.73Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
22.73Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.73Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
22.73Single7WC6LSD7WC6-5-HT2A-LSD
22.73Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
22.73Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
22.73Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
22.73Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
22.73Single8JXSPF-61428JXS-D1-PF-6142
22.73Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.73Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
22.73Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
22.73Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
22.73Single8ZMFA1L108ZMF-5-HT2C-A1L10
22.73Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
22.73Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
22.73Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
22.73Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
22.73Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
22.73Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
22.73Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
22.73Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.73Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
22.73Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
22.73Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.73Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
22.73Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.73Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.58Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
22.58Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
22.58Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
22.58Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.22Single3UZAGTPL92363UZA-A2A-GTPL9236
22.22Single4XNWMRS25004XNW-P2Y1-MRS2500
22.22Single6ME5Agomelatine6ME5-MT1-Agomelatine
22.22Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
22.22Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
22.22Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.22Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
22.22Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
22.22Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8IEBA1LYA8IEB-GPR156-A1LYA
22.22Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
22.22Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
22.22Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
22.22Consensus5ht2_onOrthosteric Ligand5ht2b_on
22.22Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
21.88Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
21.88Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.74Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
21.74Single4DJHJDTic4DJH-κ-JDTic
21.74Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.74Single5V56TC1145V56-SMO-TC114
21.74Single6E59L-7607356E59-NK1-L-760735
21.74Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.74Single6OS1TRV0266OS1-AT1-TRV026
21.74Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.74Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
21.74Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
21.74Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
21.74Single7FEECP559407FEE-CB1-CP55940-ZCZ011
21.74Single7R0CAVP7R0C-V2-AVP-Arrestin2
21.74Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
21.74Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
21.74Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
21.74Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
21.74Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
21.74Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
21.74Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.74Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
21.74Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
21.74Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
21.74Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
21.74Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
21.74Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
21.74Single8XVLZibotentan8XVL-ETA-Zibotentan
21.74Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
21.74Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
21.74Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
21.74Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
21.74Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
21.74Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
21.74Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.74Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
21.74Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
21.74Consensustachykinin_offOrthosteric Ligandnk1_off
21.43Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
21.43Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
21.43Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
21.43Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
21.43Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
21.05Single3PBLEticlopride3PBL-D3-Eticlopride
21.05Single5L7IVismodegib5L7I-SMO-Vismodegib
21.05Single6HLLCP999946HLL-NK1-CP99994
21.05Single6TP4ACT-4622066TP4-OX1-ACT-462206
21.05Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
21.05Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.05Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
21.05Single7SRQLSD7SRQ-5-HT2B-LSD
21.05Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
21.05Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
21.05Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.05Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
21.05Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
21.05Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
21.05Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
21.05Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.05Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
21.05Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
21.05Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.05Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
21.05Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
20.83Single4N4WSANT-14N4W-SMO-SANT-1
20.83Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
20.83Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
20.83Single6CM4Risperidone6CM4-D2-Risperidone
20.83Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
20.83Single6KQICP559406KQI-CB1-CP55940-Org27569
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.83Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
20.83Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
20.83Single7K15MKD0467K15-BLT1-MKD046-Na
20.83Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.83Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
20.83Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
20.83Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
20.83Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
20.83Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
20.83Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
20.83Single8XQJJN2418XQJ-Apelin-JN241
20.83Single8XWACXCL18XWA-CXCR2-CXCL1
20.83Single8XWMCXCL68XWM-CXCR2-CXCL6
20.83Single8XWSCXCL58XWS-CXCR2-CXCL5
20.83Single8XYIVUF106618XYI-CXCR3-VUF10661
20.83Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
20.83Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
20.83Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
20.83Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
20.83Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
20.83Consensuslpa_offOrthosteric Ligandlpa1_off
20.83Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.69Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
20.69Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.69Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.69Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
20.69Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
20.69Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
20.69Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
20.69Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.69Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.69Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.69Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.59Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
20.59Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
20.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
20.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
20.00Single5WS3EMPA5WS3-OX2-EMPA
20.00Single5X93K-87945X93-ETB-K-8794
20.00Single6AKXA4R6AKX-CCR5-A4R
20.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
20.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
20.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
20.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
20.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
20.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
20.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
20.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
20.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
20.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
20.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
20.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
20.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
20.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
20.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
20.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
20.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
20.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
20.00Single8XWFCXCL38XWF-CXCR2-CXCL3
20.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
20.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
20.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
20.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
20.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.00Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
20.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.00Consensusangiotensin_offOrthosteric Ligandat1_off
20.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
20.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
20.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
20.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.44Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
19.44Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
19.44Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.35Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
19.35Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
19.35Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
19.23Single5EE7MK08935EE7-Glucagon-MK0893
19.23Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.23Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
19.23Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single7SK9CCX6627SK9-ACKR3-CCX662
19.23Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
19.23Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
19.23Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
19.05Single3RZECidoxepin3RZE-H1-Cidoxepin
19.05Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
19.05Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
19.05Single4MBSMaraviroc4MBS-CCR5-Maraviroc
19.05Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
19.05Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
19.05Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
19.05Single6A94Zotepine6A94-5-HT2A-Zotepine
19.05Single6IQLL7458706IQL-D4-L745870
19.05Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
19.05Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
19.05Single6TP3Nemorexant6TP3-OX1-Nemorexant
19.05Single6TPKRetosiban6TPK-OT-Retosiban
19.05Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
19.05Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
19.05Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
19.05Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
19.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
19.05Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
19.05Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
19.05Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
19.05Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
19.05Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
19.05Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
19.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
19.05Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
19.05Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
19.05Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
19.05Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
19.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
19.05Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
19.05Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
19.05Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
19.05Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
19.05Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
19.05Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
19.05Single9BJKNaloxone9BJK-μ-Naloxone-NAM
19.05Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
19.05Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
19.05Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
19.05Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
19.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
19.05Consensusvasop-oxy_offOrthosteric Ligandot_off
18.92Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.75Single5MZPCaffeine5MZP-A2A-Caffeine-Na
18.75Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
18.75Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
18.75Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
18.75Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.52Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
18.52Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
18.52Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.52Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8IEBA1LYA8IEB-GPR156-A1LYA
18.52Single8IEIA1LYA8IEI-GPR156-A1LYA
18.52Single8IEPA1LYA8IEP-GPR156-A1LYA
18.52Single8IEPA1LYA8IEP-GPR156-A1LYA
18.52Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single8KIGSHU91198KIG-MC3-SHU9119-Ca
18.52Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
18.52Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.52Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.52Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
18.52Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
18.52Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
18.18Single2Y01Dobutamine2Y01-β1-Dobutamine
18.18Single4DAJTiotropium4DAJ-M3-Tiotropium
18.18Single4MQSIperoxo4MQS-M2-Iperoxo
18.18Single4U14Tiotropium4U14-M3-Tiotropium
18.18Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
18.18Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
18.18Single5T04Neurotensin5T04-NTS1-Neurotensin
18.18Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
18.18Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
18.18Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
18.18Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.18Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
18.18Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
18.18Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
18.18Single7BU7BI1671077BU7-β1-BI167107
18.18Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
18.18Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
18.18Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
18.18Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
18.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
18.18Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
18.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
18.18Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.18Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
18.18Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.18Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
18.18Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
18.18Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
18.18Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.18Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
18.18Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
18.18Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
18.18Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
18.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.18Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
18.18Single8X64Desloratadine8X64-H1-Desloratadine
18.18Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
18.18Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
18.18Single9IYAONO-97105319IYA-GPR55-ONO-9710531
18.18Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
18.18Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
18.18Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
18.18Consensusblt_onOrthosteric Ligandblt1_on
18.18Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
18.18Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
18.18Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
18.18Consensusleukotriene_onOrthosteric Ligandblt_on
18.18Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
18.18Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.95Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
17.86Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
17.86Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
17.86Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
17.86Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.65Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
17.65Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
17.39Single4JKVTaladegib4JKV-SMO-Taladegib
17.39Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
17.39Single5XPRBosentan5XPR-ETB-Bosentan
17.39Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.39Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.39Single6HLPNetupitant6HLP-NK1-Netupitant
17.39Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.39Single7C4SS1P7C4S-S1P3-S1P
17.39Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
17.39Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
17.39Single7SINNPS-21437SIN-CaS-NPS-2143
17.39Single7SINNPS-21437SIN-CaS-NPS-2143
17.39Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
17.39Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
17.39Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
17.39Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
17.39Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
17.39Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
17.39Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.39Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
17.39Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
17.39Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
17.39Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
17.39Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.39Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
17.39Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
17.39Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
17.39Consensusblt_offOrthosteric Ligandblt1_off
17.39Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
17.39Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.39Consensusep_offOrthosteric Ligandep4_off
17.39Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
17.39Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
17.24Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
17.24Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.24Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.24Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.14Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
17.14Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
17.14Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
16.67Single3OE8IT1t3OE8-CXCR4-IT1t
16.67Single4U15Tiotropium4U15-M3-Tiotropium
16.67Single5TZRMK86665TZR-FFA1-MK8666
16.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
16.67Single5V57TC1145V57-SMO-TC114
16.67Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
16.67Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
16.67Single6OL9Tiotropium6OL9-M5-Tiotropium
16.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.67Single7F1TMIP-1a7F1T-CCR5-MIP-1a
16.67Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.67Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
16.67Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
16.67Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
16.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
16.67Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EA0Iperoxo8EA0-M3-Iperoxo
16.67Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
16.67Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
16.67Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
16.67Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
16.67Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
16.67Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
16.67Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
16.67Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
16.67Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
16.67Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
16.67Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
16.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
16.67Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
16.67Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
16.67Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
16.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
16.67Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
16.67Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
16.67Consensuslpa_onOrthosteric Ligandlpa1_on
16.67Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
16.67Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
16.67Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
16.67Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
16.67Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
16.67Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
16.67Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.67Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.13Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
16.13Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.13Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
16.00Single5CXVTiotropium5CXV-M1-Tiotropium
16.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
16.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
16.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
16.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
16.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
16.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
16.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
16.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
16.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
16.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
16.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
16.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.79Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.79Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
15.79Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
15.79Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
15.79Single7WC5Psilocin7WC5-5-HT2A-Psilocin
15.79Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
15.79Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
15.79Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
15.79Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
15.79Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
15.79Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
15.79Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
15.79Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.79Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.62Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
15.62Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
15.62Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
15.62Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
15.62Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
15.62Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.38Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.38Single6K1QIRL25006K1Q-ETB-IRL2500
15.38Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
15.38Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
15.38Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
15.38Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
15.38Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8XVJMacitentan8XVJ-ETA-Macitentan
15.38Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
15.38Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
15.38Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
15.38Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
15.15Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.15Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.15Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
15.15Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
15.15Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
15.15Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
15.15Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
15.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
15.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
15.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
15.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.00Single7UL2SR486927UL2-NTS1-SR48692-Na
15.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
15.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
15.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
15.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
15.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
15.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
15.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
15.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
15.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
15.00Single9B9Y7DY9B9Y-CB1-7DY
15.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
15.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.00Consensusneurotensin_offOrthosteric Ligandnts1_off
15.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
14.81Single6KNMJN241-96KNM-Apelin-JN241-9
14.81Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
14.81Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
14.81Single8IEIA1LYA8IEI-GPR156-A1LYA
14.81Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
14.81Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
14.81Consensuskisspeptin_onOrthosteric Ligandkiss1_on
14.71Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
14.71Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
14.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
14.71Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
14.63Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
14.29Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
14.29Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
14.29Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
14.29Single4QINSAG1.54QIN-SMO-SAG1.5
14.29Single5U09Taranabant5U09-CB1-Taranabant
14.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
14.29Single6B73MP11046B73-κ-MP1104
14.29Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
14.29Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
14.29Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
14.29Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
14.29Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
14.29Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
14.29Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
14.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
14.29Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
14.29Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
14.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
14.29Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
14.29Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
14.29Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
14.29Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
14.29Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
14.29Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
14.29Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
14.29Single8Y0HVUF114188Y0H-CXCR3-VUF11418
14.29Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
14.29Single9BA0A1AKN9BA0-CB1-A1AKN
14.29Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
14.29Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
14.29Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
14.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
13.89Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.79Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
13.64Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
13.64Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
13.64Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.64Single6ZINSR486926ZIN-NTS1-SR48692
13.64Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
13.64Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
13.64Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
13.64Single7VV6C48/807VV6-MRGPRX2-C48/80
13.64Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
13.64Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
13.64Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
13.64Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
13.64Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
13.64Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
13.64Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
13.64Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
13.64Consensusopsins_offOrthosteric Ligandrhodopsin_off
13.64Consensussensory_offOrthosteric Ligandopsins_off
13.51Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
13.16Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.16Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.16Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
13.16Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
13.04Single5DSGTiotropium5DSG-M4-Tiotropium
13.04Single5TGZAM65385TGZ-CB1-AM6538
13.04Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.04Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.04Single6IIVDaltroban6IIV-TP-Daltroban
13.04Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
13.04Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
13.04Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
13.04Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
13.04Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
13.04Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
13.04Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
13.04Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
13.04Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.04Single9B9ZA1AKO9B9Z-CB1-A1AKO
13.04Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
13.04Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
13.04Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.04Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
13.04Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
12.90Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
12.50Single4NTJAZD12834NTJ-P2Y12-AZD1283
12.50Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
12.50Single5CGCHTL142425CGC-mGlu5-HTL14242
12.50Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
12.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
12.50Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
12.50Single6Z4SSR486926Z4S-NTS1-SR48692
12.50Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.50Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
12.50Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
12.50Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
12.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
12.50Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
12.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
12.50Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.50Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.50Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
12.50Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
12.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
12.00Single7P2L4YI7P2L-mGlu5-4YI
12.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
12.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
12.00Single9BJKNAM9BJK-μ-Naloxone-NAM
12.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
12.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
12.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.76Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
11.76Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
11.76Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single5X33BIIL2605X33-BLT1-BIIL260
11.54Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
11.54Single6IIURamatroban6IIU-TP-Ramatroban
11.54Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
11.54Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
11.54Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.43Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
11.43Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
11.43Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
11.11Single5CGDHTL142425CGD-mGlu5-HTL14242
11.11Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.11Single7WC4Serotonin7WC4-5-HT2A-Serotonin
11.11Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.11Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
11.11Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
11.11Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.81Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.71Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
10.71Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.71Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
10.53Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.53Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
10.53Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
10.53Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
10.53Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
10.53Consensussensory_onOrthosteric Ligandopsins_on
10.34Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
10.34Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
10.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
10.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
10.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.00Single8JPSCCL78JPS-ACKR1-CCL7
10.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
10.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
10.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
9.52Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.52Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
9.52Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.52Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
9.52Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
9.52Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
9.52Single6LI0C176LI0-GPR52-C17
9.52Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
9.52Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
9.52Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
9.52Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
9.52Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.52Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
9.38Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
9.09Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.09Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.09Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.09Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.09Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
9.09Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.09Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.09Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.09Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
9.09Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
8.70Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
8.70Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
8.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.70Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.70Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8K2WAMG4878K2W-CXCR3-AMG487
8.70Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.70Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
8.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.33Single6GPSMK08126GPS-CCR2-MK0812
8.33Single7F83PF-051904577F83-Ghrelin-PF-05190457
8.33Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
8.33Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
8.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.00Single6GPXMK08126GPX-CCR2-MK0812
8.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.69Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
7.69Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
7.69Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
7.41Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
7.41Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
7.14Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
7.14Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.14Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
6.90Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
6.67Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
6.67Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.56Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.26Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
5.26Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.26Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.26Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
5.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
5.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.00Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.76Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
4.76Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.76Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.55Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
4.55Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
4.55Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.55Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
4.55Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.55Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
4.55Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
4.35Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
4.35Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.35Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
4.35Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
4.35Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
4.35Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
4.35Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
4.17Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
4.17Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.17Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
4.17Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.17Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.00Single6FFHFenobam6FFH-mGlu5-Fenobam
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.70Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.70Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.12Single7SHEPI; PE7SHE-GPR158-PI; PE
3.12Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
ccka_on_gp 7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
cckb_on_gp 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
Net Summary
Imin 3.255
Number of Linked Nodes 880
Number of Links 1030
Number of Hubs 149
Number of Links mediated by Hubs 586
Number of Communities 25
Number of Nodes involved in Communities 198
Number of Links involved in Communities 276
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 797867
Length Of Smallest Path 3
Average Path Length 25.4257
Length of Longest Path 61
Minimum Path Strength 0.24
Average Path Strength 6.23343
Maximum Path Strength 25.8575
Minimum Path Correlation 0.703333
Average Path Correlation 0.970351
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 47.4715
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.2055
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
cck_off_on_gpcck_on_gpcck_off
This network is also present in following consensuses:
IdComponents
peptide_on_gpcck_on_gp
angiotensin_on_gp
apelin_on_gp
bombesin_on_gp
bradykinin_on_gp
compl-peptide_on_gp
endothelin_on_gp
formylpeptide_on_gp
galanin_on_gp
ghrelin_on_gp
kisspeptin_on_gp
melanocortin_on_gp
motilin_on_gp
neuromedin-u_on_gp
npy_on_gp
neurotensin_on_gp
opioid_on_gp
orexin_on_gp
relaxin_on_gp
somatostatin_on_gp
tachykinin_on_gp
trh_on_gp
vasop-oxy_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download cck_on_gp.zip



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