Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:R15 R:R:T31 3.88 0 No No 0 5 0 1
L:L:R22 R:R:I32 3.76 12 Yes No 0 4 0 1
R:R:R305 R:R:T33 3.88 0 Yes Yes 5 7 1 2
R:R:L309 R:R:T33 4.42 0 No Yes 5 7 1 2
L:L:R22 R:R:I34 3.76 12 Yes No 0 3 0 1
L:L:W25 R:R:I34 5.87 0 Yes No 0 3 0 1
R:R:E35 R:R:R305 11.63 0 No Yes 6 5 2 1
R:R:L40 R:R:Q37 2.66 0 No Yes 3 7 2 1
R:R:I90 R:R:Q37 4.12 3 Yes Yes 6 7 2 1
L:L:R22 R:R:Q37 3.5 12 Yes Yes 0 7 0 1
L:L:W25 R:R:I38 5.87 0 Yes No 0 5 0 1
R:R:L70 R:R:P87 3.28 3 Yes Yes 6 8 2 2
R:R:I90 R:R:L70 2.85 3 Yes Yes 6 6 2 2
R:R:F93 R:R:L70 6.09 3 Yes Yes 5 6 1 2
R:R:R101 R:R:W73 21.99 3 Yes Yes 8 9 2 2
R:R:W73 R:R:Y122 6.75 3 Yes Yes 9 5 2 1
R:R:C86 R:R:P87 1.88 3 Yes Yes 9 8 2 2
R:R:C86 R:R:F93 2.79 3 Yes Yes 9 5 2 1
R:R:C125 R:R:C86 7.28 3 No Yes 9 9 2 2
R:R:I90 R:R:P87 1.69 3 Yes Yes 6 8 2 2
R:R:F93 R:R:P87 5.78 3 Yes Yes 5 8 1 2
R:R:F93 R:R:I90 16.33 3 Yes Yes 5 6 1 2
R:R:D92 R:R:Y91 5.75 12 No No 4 4 1 1
L:L:R22 R:R:Y91 7.2 12 Yes No 0 4 0 1
L:L:R22 R:R:D92 14.29 12 Yes No 0 4 0 1
L:L:R23 R:R:D92 20.25 0 No No 0 4 0 1
R:R:C125 R:R:F93 5.59 3 No Yes 9 5 2 1
R:R:F93 R:R:L126 4.87 3 Yes No 5 3 1 1
L:L:L26 R:R:F93 7.31 0 No Yes 0 5 0 1
L:L:M30 R:R:F93 2.49 3 No Yes 0 5 0 1
R:R:A99 R:R:Y122 2.67 0 No Yes 7 5 2 1
R:R:A120 R:R:R101 4.15 3 No Yes 7 8 2 2
R:R:R101 R:R:Y122 3.09 3 Yes Yes 8 5 2 1
R:R:A120 R:R:Y122 6.67 3 No Yes 7 5 2 1
L:L:M30 R:R:Y122 8.38 3 No Yes 0 5 0 1
L:L:M30 R:R:L126 2.83 3 No No 0 3 0 1
L:L:R23 R:R:Q130 12.85 0 No No 0 3 0 1
R:R:I133 R:R:K137 2.91 0 No No 2 3 2 1
L:L:L16 R:R:S134 3 0 No No 0 3 0 1
L:L:L20 R:R:S134 6.01 0 No No 0 3 0 1
L:L:L16 R:R:K137 5.64 0 No No 0 3 0 1
L:L:L20 R:R:Q138 3.99 0 No No 0 2 0 1
R:R:F140 R:R:F141 3.22 2 Yes Yes 5 5 2 1
R:R:F140 R:R:L144 2.44 2 Yes Yes 5 6 2 2
R:R:F140 R:R:M395 2.49 2 Yes Yes 5 7 2 1
L:L:E12 R:R:F141 5.83 0 No Yes 0 5 0 1
L:L:R13 R:R:F141 11.76 0 No Yes 0 5 0 1
L:L:L16 R:R:F141 3.65 0 No Yes 0 5 0 1
L:L:R13 R:R:E142 3.49 0 No No 0 2 0 1
R:R:L144 R:R:M395 2.83 2 Yes Yes 6 7 2 1
R:R:L144 R:R:L399 5.54 2 Yes Yes 6 8 2 1
R:R:Y148 R:R:Y152 4.96 2 Yes Yes 7 8 2 1
R:R:I194 R:R:Y148 2.42 2 Yes Yes 7 7 1 2
R:R:D198 R:R:Y148 5.75 2 Yes Yes 8 7 2 2
R:R:L399 R:R:Y148 2.34 2 Yes Yes 8 7 1 2
R:R:R190 R:R:Y152 6.17 2 Yes Yes 8 8 1 1
R:R:I194 R:R:Y152 9.67 2 Yes Yes 7 8 1 1
R:R:F195 R:R:Y152 2.06 0 No Yes 8 8 2 1
R:R:S403 R:R:Y152 3.82 2 No Yes 9 8 2 1
L:L:D6 R:R:Y152 6.9 2 Yes Yes 0 8 0 1
R:R:L247 R:R:R190 4.86 2 No Yes 6 8 1 1
R:R:N250 R:R:R190 9.64 0 No Yes 9 8 2 1
R:R:R190 R:R:Y251 5.14 2 Yes Yes 8 7 1 1
L:L:D6 R:R:R190 4.76 2 Yes Yes 0 8 0 1
R:R:I194 R:R:K197 2.91 2 Yes Yes 7 7 1 1
R:R:D198 R:R:I194 2.8 2 Yes Yes 8 7 2 1
R:R:F243 R:R:I194 2.51 2 Yes Yes 6 7 1 1
L:L:D6 R:R:I194 5.6 2 Yes Yes 0 7 0 1
R:R:D198 R:R:K197 5.53 2 Yes Yes 8 7 2 1
R:R:A239 R:R:K197 3.21 0 No Yes 7 7 2 1
R:R:F243 R:R:K197 17.37 2 Yes Yes 6 7 1 1
L:L:F10 R:R:K197 16.13 2 Yes Yes 0 7 0 1
R:R:C236 R:R:V201 1.71 0 No Yes 9 6 2 1
R:R:A239 R:R:V201 1.7 0 No Yes 7 6 2 1
R:R:E308 R:R:V201 2.85 2 Yes Yes 6 6 1 1
L:L:F10 R:R:V201 6.55 2 Yes Yes 0 6 0 1
R:R:E308 R:R:I205 2.73 2 Yes No 6 4 1 1
L:L:E21 R:R:I205 4.1 0 No No 0 4 0 1
R:R:C236 R:R:C306 7.28 0 No No 9 9 2 2
R:R:V240 R:R:W294 2.45 2 Yes Yes 6 8 1 1
R:R:C306 R:R:V240 1.71 0 No Yes 9 6 2 1
R:R:V240 R:R:W307 3.68 2 Yes Yes 6 8 1 2
L:L:F10 R:R:V240 2.62 2 Yes Yes 0 6 0 1
R:R:F243 R:R:I244 3.77 2 Yes Yes 6 7 1 1
L:L:D6 R:R:F243 10.75 2 Yes Yes 0 6 0 1
L:L:D7 R:R:F243 7.17 2 Yes Yes 0 6 0 1
L:L:F10 R:R:F243 5.36 2 Yes Yes 0 6 0 1
R:R:I244 R:R:W294 8.22 2 Yes Yes 7 8 1 1
R:R:I244 R:R:Y318 8.46 2 Yes Yes 7 8 1 1
L:L:D7 R:R:I244 4.2 2 Yes Yes 0 7 0 1
L:L:R11 R:R:I244 2.51 2 Yes Yes 0 7 0 1
R:R:L247 R:R:Y251 10.55 2 No Yes 6 7 1 1
L:L:L4 R:R:L247 2.77 2 No No 0 6 0 1
R:R:A248 R:R:F290 2.77 2 No Yes 7 5 2 2
R:R:A248 R:R:I322 3.25 2 No Yes 7 8 2 1
R:R:I322 R:R:Y251 3.63 2 Yes Yes 8 7 1 1
R:R:Y251 R:R:Y376 15.89 2 Yes Yes 7 8 1 2
L:L:L4 R:R:Y251 3.52 2 No Yes 0 7 0 1
R:R:F290 R:R:Y318 2.06 2 Yes Yes 5 8 2 1
R:R:F290 R:R:I322 5.02 2 Yes Yes 5 8 2 1
R:R:R298 R:R:W294 8 2 Yes Yes 8 8 2 1
R:R:W294 R:R:W307 6.56 2 Yes Yes 8 8 1 2
R:R:I314 R:R:W294 4.7 2 Yes Yes 3 8 2 1
R:R:I317 R:R:W294 3.52 0 No Yes 9 8 2 1
R:R:W294 R:R:Y318 8.68 2 Yes Yes 8 8 1 1
L:L:R11 R:R:W294 2 2 Yes Yes 0 8 0 1
R:R:R298 R:R:W307 23.99 2 Yes Yes 8 8 2 2
R:R:I314 R:R:R298 3.76 2 Yes Yes 3 8 2 2
R:R:E308 R:R:R305 3.49 2 Yes Yes 6 5 1 1
L:L:E21 R:R:R305 5.82 0 No Yes 0 5 0 1
R:R:C306 R:R:E308 3.04 0 No Yes 9 6 2 1
L:L:F10 R:R:E308 4.66 2 Yes Yes 0 6 0 1
L:L:A14 R:R:E308 7.54 0 No Yes 0 6 0 1
L:L:S1 R:R:S310 4.89 2 No No 0 7 0 1
L:L:R11 R:R:S310 3.95 2 Yes No 0 7 0 1
R:R:G312 R:R:K315 5.23 0 No Yes 5 6 2 1
R:R:K315 R:R:W316 5.8 2 Yes No 6 6 1 2
R:R:K315 R:R:Y318 3.58 2 Yes Yes 6 8 1 1
R:R:K315 R:R:Q319 14.92 2 Yes Yes 6 7 1 1
L:L:S1 R:R:K315 9.18 2 No Yes 0 6 0 1
L:L:L2 R:R:K315 2.82 0 No Yes 0 6 0 1
R:R:Q319 R:R:W316 7.67 2 Yes No 7 6 1 2
R:R:Q319 R:R:Y318 5.64 2 Yes Yes 7 8 1 1
L:L:D7 R:R:Y318 9.2 2 Yes Yes 0 8 0 1
L:L:R11 R:R:Y318 9.26 2 Yes Yes 0 8 0 1
L:L:A3 R:R:Q319 3.03 0 No Yes 0 7 0 1
L:L:L4 R:R:I322 5.71 2 No Yes 0 8 0 1
L:L:A3 R:R:L323 4.73 0 No No 0 5 0 1
R:R:E398 R:R:F379 5.83 0 No Yes 8 7 1 2
R:R:M395 R:R:W391 4.65 2 Yes No 7 5 1 1
L:L:E12 R:R:W391 4.36 0 No No 0 5 0 1
R:R:E398 R:R:R394 15.12 0 No No 8 7 1 2
R:R:L399 R:R:M395 4.24 2 Yes Yes 8 7 1 1
L:L:A5 R:R:E398 6.03 0 No No 0 8 0 1
L:L:D6 R:R:L399 4.07 2 Yes Yes 0 8 0 1
L:L:A8 R:R:M395 1.61 0 No Yes 0 7 0 1
L:L:A9 R:R:M395 1.61 0 No Yes 0 7 0 1
R:R:P131 R:R:Q130 1.58 0 No No 2 3 2 1
L:L:A18 R:R:L309 1.58 0 No No 0 5 0 1
R:R:I205 R:R:S231 1.55 0 No No 4 4 1 2
R:R:I34 R:R:T33 1.52 0 No Yes 3 7 1 2
R:R:Q37 R:R:V41 1.43 0 Yes No 7 5 1 2
R:R:I38 R:R:L42 1.43 0 No No 5 2 1 2
R:R:I38 R:R:L210 1.43 0 No No 5 4 1 2
R:R:I135 R:R:Q138 1.37 0 No No 1 2 2 1
L:L:K32 R:R:E209 1.35 0 No No 0 4 0 1
L:L:W25 R:R:E209 1.09 0 Yes No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7F16
Class B1
SubFamily Peptide
Type Parathyroid hormone
SubType PTH2
Species Homo sapiens
Ligand TIP39
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.8
Date 2021-08-18
D.O.I. 10.1073/pnas.2101279118
Net Summary
Imin 1.68
Number of Linked Nodes 946
Number of Links 1363
Number of Hubs 301
Number of Links mediated by Hubs 1047
Number of Communities 13
Number of Nodes involved in Communities 424
Number of Links involved in Communities 728
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 2987350
Length Of Smallest Path 3
Average Path Length 30.828
Length of Longest Path 66
Minimum Path Strength 1.025
Average Path Strength 5.83597
Maximum Path Strength 27.08
Minimum Path Correlation 0.7
Average Path Correlation 0.992536
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 55.1978
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 62.7557
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7F16_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKNT 
IVKQMSGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSQT NRLQAALKL FDSIWNNKW LRDTSVILF LNKQDLLAE 
KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT RAKYFIRDE 
FLRISTASG DGRHYCYPH FTCAVDTEN IRRVFNDCR DIIQRMHLR 
QYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7F16_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7F16_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP49190
Sequence
>7F16_Chain_R
TITIEEQIV LVLKAKVQC ELNITAQLQ EGEGNCFPE WDGLICWPR 
GTVGKISAV PCPPYIYDF NHKGVAFRH CNPNGTWDF MHSLNKTWA 
NYSDCLRFL QPDISIGKQ EFFERLYVM YTVGYSISF GSLAVAILI 
IGYFRRLHC TRNYIHMHL FVSFMLRAT SIFVKDRVV HAHIGVKEL 
ESQYIGCKI AVVMFIYFL ATNYYWILV EGLYLHNLI FVAFFSDTK 
YLWGFILIG WGFPAAFVA AWAVARATL ADARCWELS AGDIKWIYQ 
APILAAIGL NFILFLNTV RVLATKIWE TDTRKQYRK LAKSTLVLV 
LVFGVHYIV FVCLPGLGW EIRMHCELF FNSFQGFFV SIIYCYCNG 
EVQAEVKKM WSRWNLS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
pth2_on7F16-PTH2-TIP39-Gs/&β;1/&γ;2
gs_pth8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
7F16-PTH2-TIP39-Gs/&β;1/&γ;2
7VVM-PTH1-PTH-Gs/&β;1/&γ;2
8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F16B1PeptideParathyroid hormonePTH2Homo sapiensTIP39-Gs/&β;1/&γ;22.82021-08-1810.1073/pnas.2101279118




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