psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R15	R:R:T31	3.88	No	No	0	0	5
2	L:L:R22	R:R:I32	3.76	Yes	No	0	0	4
3	R:R:E36	R:R:T33	4.23	No	Yes	0	6	7
4	R:R:R305	R:R:T33	3.88	Yes	Yes	0	5	7
5	R:R:L309	R:R:T33	4.42	No	Yes	0	5	7
6	L:L:R22	R:R:I34	3.76	Yes	No	0	0	3
7	L:L:W25	R:R:I34	5.87	Yes	No	0	0	3
8	R:R:E35	R:R:K208	13.5	No	No	0	6	4
9	R:R:E35	R:R:R305	11.63	No	Yes	0	6	5
10	R:R:I90	R:R:Q37	4.12	No	Yes	0	6	7
11	L:L:R22	R:R:Q37	3.5	Yes	Yes	0	0	7
12	L:L:W25	R:R:I38	5.87	Yes	No	0	0	5
13	R:R:K43	R:R:V39	6.07	No	No	0	4	2
14	R:R:A44	R:R:Y89	6.67	No	Yes	0	7	5
15	R:R:K45	R:R:W67	9.28	No	Yes	0	5	7
16	R:R:C48	R:R:W67	11.75	No	Yes	8	9	7
17	R:R:C48	R:R:C72	7.28	No	No	8	9	9
18	R:R:I52	R:R:L56	4.28	No	No	0	4	3
19	R:R:E58	R:R:R75	4.65	No	Yes	0	1	4
20	R:R:E60	R:R:G61	3.27	No	No	0	3	1
21	R:R:E60	R:R:N62	15.77	No	No	0	3	3
22	R:R:E60	R:R:R75	9.3	No	Yes	0	3	4
23	R:R:N62	R:R:V78	4.43	No	No	0	3	7
24	R:R:C103	R:R:C63	7.28	No	No	0	9	9
25	R:R:C63	R:R:W109	10.45	No	Yes	0	9	9
26	R:R:D68	R:R:E66	16.89	No	Yes	2	9	6
27	R:R:E66	R:R:W73	4.36	Yes	Yes	2	6	9
28	R:R:E66	R:R:R101	4.65	Yes	Yes	2	6	8
29	R:R:E66	R:R:W109	14.17	Yes	Yes	2	6	9
30	R:R:G69	R:R:W67	8.44	No	Yes	0	5	7
31	R:R:C72	R:R:W67	3.92	No	Yes	8	9	7
32	R:R:D68	R:R:W73	6.7	No	Yes	2	9	9
33	R:R:D68	R:R:R101	9.53	No	Yes	2	9	8
34	R:R:I71	R:R:L70	5.71	Yes	No	2	5	6
35	R:R:L70	R:R:P87	3.28	No	Yes	2	6	8
36	R:R:F93	R:R:L70	6.09	Yes	No	2	5	6
37	R:R:I71	R:R:W73	8.22	Yes	Yes	2	5	9
38	R:R:I71	R:R:V84	3.07	Yes	Yes	2	5	5
39	R:R:I71	R:R:P87	5.08	Yes	Yes	2	5	8
40	R:R:V84	R:R:W73	4.9	Yes	Yes	2	5	9
41	R:R:R101	R:R:W73	21.99	Yes	Yes	2	8	9
42	R:R:W73	R:R:Y122	6.75	Yes	Yes	2	9	5
43	R:R:P74	R:R:S82	3.56	No	No	0	5	7
44	R:R:P74	R:R:V84	3.53	No	Yes	0	5	5
45	R:R:G76	R:R:W109	4.22	No	Yes	0	7	9
46	R:R:K80	R:R:T77	6.01	No	No	0	5	1
47	R:R:F100	R:R:I81	3.77	Yes	No	0	4	4
48	R:R:H102	R:R:I81	5.3	No	No	0	3	4
49	R:R:A83	R:R:V98	5.09	No	No	0	4	3
50	R:R:P85	R:R:V84	3.53	No	Yes	0	4	5
51	R:R:C125	R:R:C86	7.28	No	No	0	9	9
52	R:R:P87	R:R:Y89	5.56	Yes	Yes	0	8	5
53	R:R:F93	R:R:P87	5.78	Yes	Yes	2	5	8
54	R:R:H95	R:R:P88	3.05	No	No	0	5	3
55	R:R:I90	R:R:Y89	4.84	No	Yes	0	6	5
56	R:R:F93	R:R:I90	16.33	Yes	No	0	5	6
57	R:R:D92	R:R:Y91	5.75	No	No	7	4	4
58	L:L:R22	R:R:Y91	7.2	Yes	No	7	0	4
59	L:L:R22	R:R:D92	14.29	Yes	No	7	0	4
60	L:L:R23	R:R:D92	20.25	No	No	0	0	4
61	R:R:C125	R:R:F93	5.59	No	Yes	0	9	5
62	R:R:F93	R:R:L126	4.87	Yes	No	0	5	3
63	L:L:L26	R:R:F93	7.31	No	Yes	0	0	5
64	R:R:K96	R:R:N94	5.6	No	No	0	3	5
65	R:R:N94	R:R:R127	13.26	No	No	0	5	1
66	R:R:F100	R:R:V98	3.93	Yes	No	9	4	3
67	R:R:D124	R:R:V98	4.38	No	No	9	5	3
68	R:R:F100	R:R:N121	3.62	Yes	No	0	4	8
69	R:R:D124	R:R:F100	4.78	No	Yes	9	5	4
70	R:R:R101	R:R:W109	10	Yes	Yes	2	8	9
71	R:R:R101	R:R:T118	6.47	Yes	No	0	8	6
72	R:R:A120	R:R:R101	4.15	No	Yes	2	7	8
73	R:R:R101	R:R:Y122	3.09	Yes	Yes	2	8	5
74	R:R:D110	R:R:H102	8.82	No	No	0	4	3
75	R:R:N104	R:R:N106	5.45	Yes	No	0	5	4
76	R:R:N104	R:R:T108	5.85	Yes	No	0	5	5
77	R:R:D110	R:R:N104	5.39	No	Yes	0	4	5
78	R:R:F111	R:R:N116	9.67	No	No	0	1	7
79	R:R:M112	R:R:W119	3.49	No	No	0	4	5
80	R:R:A120	R:R:Y122	6.67	No	Yes	2	7	5
81	R:R:N121	R:R:S123	7.45	No	No	0	8	6
82	L:L:M30	R:R:Y122	8.38	No	Yes	0	0	5
83	R:R:D124	R:R:S123	2.94	No	No	0	5	6
84	L:L:R23	R:R:Q130	12.85	No	No	0	0	3
85	L:L:L16	R:R:S134	3	No	No	0	0	3
86	L:L:L20	R:R:S134	6.01	No	No	0	0	3
87	L:L:L16	R:R:K137	5.64	No	No	0	0	3
88	L:L:L20	R:R:Q138	3.99	No	No	0	0	2
89	R:R:F140	R:R:F141	3.22	Yes	Yes	0	5	5
90	R:R:F140	R:R:R143	4.28	Yes	No	0	5	5
91	R:R:E392	R:R:F140	25.65	No	Yes	0	4	5
92	R:R:F140	R:R:H396	7.92	Yes	No	0	5	6
93	L:L:E12	R:R:F141	5.83	No	Yes	0	0	5
94	L:L:R13	R:R:F141	11.76	No	Yes	0	0	5
95	L:L:L16	R:R:F141	3.65	No	Yes	0	0	5
96	L:L:R13	R:R:E142	3.49	No	No	0	0	2
97	R:R:H396	R:R:L144	6.43	No	No	0	6	6
98	R:R:L144	R:R:L399	5.54	No	No	0	6	8
99	R:R:Y145	R:R:Y148	11.91	No	No	1	5	7
100	R:R:T149	R:R:Y145	8.74	No	No	0	7	5
101	R:R:D198	R:R:Y145	13.79	No	No	1	8	5
102	R:R:F400	R:R:M147	3.73	No	No	0	5	6
103	R:R:Y148	R:R:Y152	4.96	No	Yes	1	7	8
104	R:R:D198	R:R:Y148	5.75	No	No	1	8	7
105	R:R:G151	R:R:S403	3.71	No	No	1	9	9
106	R:R:F404	R:R:G151	6.02	Yes	No	1	7	9
107	R:R:R190	R:R:Y152	6.17	Yes	Yes	1	8	8
108	R:R:I194	R:R:Y152	9.67	No	Yes	1	7	8
109	R:R:S403	R:R:Y152	3.82	No	Yes	1	9	8
110	L:L:D6	R:R:Y152	6.9	Yes	Yes	1	0	8
111	R:R:F195	R:R:S153	5.28	No	No	0	8	7
112	R:R:F404	R:R:I154	5.02	Yes	No	0	7	4
113	R:R:F407	R:R:I154	5.02	No	No	0	6	4
114	R:R:G406	R:R:S155	3.71	No	No	0	9	9
115	R:R:F156	R:R:M188	8.71	Yes	No	0	6	7
116	R:R:F156	R:R:T192	3.89	Yes	No	0	6	4
117	R:R:F407	R:R:S158	5.28	No	No	0	6	7
118	R:R:S158	R:R:S410	6.52	No	No	0	7	9
119	R:R:S158	R:R:Y415	6.36	No	No	0	7	8
120	R:R:F184	R:R:L159	8.53	Yes	No	5	9	9
121	R:R:F187	R:R:L159	3.65	Yes	No	5	8	9
122	R:R:L159	R:R:S410	6.01	No	No	0	9	9
123	R:R:A160	R:R:M188	3.22	No	No	0	3	7
124	R:R:I165	R:R:V161	3.07	No	No	0	8	5
125	R:R:A162	R:R:C414	3.61	No	No	0	9	9
126	R:R:F184	R:R:I163	3.77	Yes	No	0	9	5
127	R:R:I163	R:R:M188	2.92	No	No	0	5	7
128	R:R:F169	R:R:I165	3.77	Yes	No	0	7	8
129	R:R:C414	R:R:I165	4.91	No	No	0	9	8
130	R:R:I166	R:R:M181	2.92	No	No	0	8	7
131	R:R:F169	R:R:Y168	5.16	Yes	No	0	7	3
132	R:R:F169	R:R:L172	6.09	Yes	No	10	7	9
133	R:R:E423	R:R:F169	5.83	No	Yes	10	8	7
134	R:R:F169	R:R:M427	3.73	Yes	No	0	7	4
135	R:R:H173	R:R:R170	4.51	No	No	0	8	8
136	R:R:E423	R:R:R171	5.82	No	No	0	8	7
137	R:R:E423	R:R:L172	3.98	No	No	10	8	9
138	R:R:T175	R:R:Y260	3.75	Yes	Yes	4	8	9
139	R:R:D272	R:R:T175	5.78	No	Yes	4	6	8
140	R:R:L276	R:R:T175	5.9	No	Yes	0	6	8
141	R:R:N177	R:R:R176	10.85	No	Yes	0	9	9
142	R:R:H180	R:R:R176	5.64	No	Yes	0	9	9
143	R:R:E419	R:R:R176	3.49	No	Yes	0	9	9
144	R:R:H182	R:R:Y178	16.33	No	No	11	8	6
145	R:R:L276	R:R:Y178	7.03	No	No	0	6	6
146	R:R:I280	R:R:Y178	3.63	No	No	11	6	6
147	R:R:I179	R:R:Y260	8.46	No	Yes	0	9	9
148	R:R:E257	R:R:H180	16	No	No	0	9	9
149	R:R:H180	R:R:Y413	21.78	No	No	0	9	9
150	R:R:H182	R:R:W253	12.7	No	Yes	0	8	9
151	R:R:H182	R:R:I280	6.63	No	No	11	8	6
152	R:R:F184	R:R:L183	3.65	Yes	No	5	9	9
153	R:R:F187	R:R:L183	9.74	Yes	No	5	8	9
154	R:R:E257	R:R:L183	10.6	No	No	0	9	9
155	R:R:F184	R:R:F187	4.29	Yes	Yes	5	9	8
156	R:R:L189	R:R:V185	2.98	No	No	0	7	5
157	R:R:S186	R:R:T249	4.8	No	Yes	0	9	8
158	R:R:N250	R:R:S186	4.47	No	No	0	9	9
159	R:R:S186	R:R:W253	3.71	No	Yes	0	9	9
160	R:R:F187	R:R:N250	8.46	Yes	No	0	8	9
161	R:R:F187	R:R:G406	9.03	Yes	No	0	8	9
162	R:R:F187	R:R:V409	7.87	Yes	No	0	8	9
163	R:R:F246	R:R:L189	9.74	Yes	No	0	5	7
164	R:R:L247	R:R:R190	4.86	No	Yes	1	6	8
165	R:R:N250	R:R:R190	9.64	No	Yes	0	9	8
166	R:R:R190	R:R:Y251	5.14	Yes	Yes	1	8	7
167	L:L:D6	R:R:R190	4.76	Yes	Yes	1	0	8
168	R:R:F246	R:R:S193	5.28	Yes	No	0	5	7
169	L:L:D6	R:R:I194	5.6	Yes	No	1	0	7
170	R:R:D198	R:R:K197	5.53	No	Yes	1	8	7
171	R:R:A239	R:R:K197	3.21	No	Yes	0	7	7
172	R:R:F243	R:R:K197	17.37	Yes	Yes	1	6	7
173	L:L:F10	R:R:K197	16.13	Yes	Yes	1	0	7
174	L:L:F10	R:R:V201	6.55	Yes	No	0	0	6
175	R:R:G235	R:R:H204	4.77	No	Yes	0	4	4
176	R:R:C236	R:R:H204	7.37	No	Yes	0	9	4
177	L:L:E21	R:R:I205	4.1	No	No	0	0	4
178	R:R:I234	R:R:I238	7.36	No	No	12	4	4
179	R:R:C236	R:R:C306	7.28	No	No	0	9	9
180	R:R:D303	R:R:K237	5.53	No	No	0	7	8
181	R:R:K237	R:R:W307	30.17	No	Yes	0	8	8
182	R:R:V240	R:R:W307	3.68	No	Yes	0	6	8
183	R:R:F246	R:R:M242	7.46	Yes	No	0	5	5
184	R:R:F243	R:R:I244	3.77	Yes	Yes	1	6	7
185	L:L:D6	R:R:F243	10.75	Yes	Yes	1	0	6
186	L:L:D7	R:R:F243	7.17	Yes	Yes	1	0	6
187	L:L:F10	R:R:F243	5.36	Yes	Yes	1	0	6
188	R:R:I244	R:R:W294	8.22	Yes	Yes	1	7	8
189	R:R:I244	R:R:Y318	8.46	Yes	Yes	1	7	8
190	L:L:D7	R:R:I244	4.2	Yes	Yes	1	0	7
191	R:R:F246	R:R:Y245	9.28	Yes	Yes	6	5	9
192	R:R:T249	R:R:Y245	8.74	Yes	Yes	6	8	9
193	R:R:W284	R:R:Y245	3.86	No	Yes	6	9	9
194	R:R:V291	R:R:Y245	7.57	No	Yes	0	7	9
195	R:R:F246	R:R:T249	3.89	Yes	Yes	6	5	8
196	R:R:L247	R:R:Y251	10.55	No	Yes	1	6	7
197	R:R:A248	R:R:I322	3.25	No	Yes	0	7	8
198	R:R:T249	R:R:W284	6.06	Yes	No	6	8	9
199	R:R:I322	R:R:Y251	3.63	Yes	Yes	1	8	7
200	R:R:Y251	R:R:Y376	15.89	Yes	Yes	1	7	8
201	L:L:L4	R:R:Y251	3.52	No	Yes	1	0	7
202	R:R:F286	R:R:Y252	8.25	No	Yes	1	4	5
203	R:R:P287	R:R:Y252	8.34	No	Yes	1	9	5
204	R:R:F290	R:R:Y252	6.19	Yes	Yes	1	5	5
205	R:R:A325	R:R:Y252	6.67	No	Yes	0	7	5
206	R:R:V256	R:R:W253	6.13	No	Yes	0	8	9
207	R:R:G283	R:R:W253	4.22	No	Yes	0	9	9
208	R:R:W253	R:R:W284	12.18	Yes	No	0	9	9
209	R:R:I254	R:R:N329	4.25	No	No	0	9	9
210	R:R:L255	R:R:L259	6.92	No	No	0	8	7
211	R:R:A325	R:R:L255	4.73	No	No	0	7	8
212	R:R:L255	R:R:L328	4.15	No	No	0	8	7
213	R:R:F279	R:R:V256	3.93	No	No	0	7	8
214	R:R:F372	R:R:G258	4.52	Yes	No	0	9	9
215	R:R:L259	R:R:L332	5.54	No	No	0	7	8
216	R:R:L264	R:R:Y260	9.38	No	Yes	4	8	9
217	R:R:F270	R:R:Y260	4.13	Yes	Yes	4	6	9
218	R:R:D272	R:R:Y260	8.05	No	Yes	4	6	9
219	R:R:F279	R:R:Y260	8.25	No	Yes	4	7	9
220	R:R:I265	R:R:L261	4.28	No	No	0	8	9
221	R:R:F372	R:R:L261	4.87	Yes	No	0	9	9
222	R:R:F266	R:R:H262	15.84	No	Yes	3	7	9
223	R:R:H262	R:R:L332	14.14	Yes	No	0	9	8
224	R:R:H262	R:R:N335	11.48	Yes	No	3	9	8
225	R:R:H262	R:R:T336	4.11	Yes	No	3	9	9
226	R:R:N263	R:R:V267	4.43	No	No	0	7	5
227	R:R:F270	R:R:N263	14.5	Yes	No	0	6	7
228	R:R:F270	R:R:L264	4.87	Yes	No	4	6	8
229	R:R:I265	R:R:V339	3.07	No	No	0	8	8
230	R:R:F266	R:R:N335	12.08	No	No	3	7	8
231	R:R:F270	R:R:Y275	9.28	Yes	No	0	6	5
232	R:R:F270	R:R:F279	4.29	Yes	No	4	6	7
233	R:R:K274	R:R:S271	4.59	No	No	0	6	7
234	R:R:K274	R:R:Y275	7.17	No	No	0	6	5
235	R:R:G283	R:R:I282	3.53	No	No	0	9	6
236	R:R:F286	R:R:P287	4.33	No	No	1	4	9
237	R:R:F286	R:R:F290	5.36	No	Yes	1	4	5
238	R:R:F290	R:R:P287	4.33	Yes	No	1	5	9
239	R:R:F290	R:R:P321	5.78	Yes	No	0	5	9
240	R:R:F290	R:R:I322	5.02	Yes	Yes	1	5	8
241	R:R:R298	R:R:W294	8	Yes	Yes	1	8	8
242	R:R:W294	R:R:W307	6.56	Yes	Yes	1	8	8
243	R:R:I314	R:R:W294	4.7	Yes	Yes	1	3	8
244	R:R:I317	R:R:W294	3.52	No	Yes	0	9	8
245	R:R:W294	R:R:Y318	8.68	Yes	Yes	1	8	8
246	R:R:R298	R:R:W307	23.99	Yes	Yes	1	8	8
247	R:R:I314	R:R:R298	3.76	Yes	Yes	1	3	8
248	R:R:I314	R:R:L301	4.28	Yes	No	0	3	3
249	R:R:E308	R:R:R305	3.49	Yes	Yes	0	6	5
250	L:L:E21	R:R:R305	5.82	No	Yes	0	0	5
251	R:R:C306	R:R:E308	3.04	No	Yes	0	9	6
252	L:L:F10	R:R:E308	4.66	Yes	Yes	0	0	6
253	L:L:A14	R:R:E308	7.54	No	Yes	0	0	6
254	L:L:S1	R:R:S310	4.89	No	No	1	0	7
255	L:L:R11	R:R:S310	3.95	Yes	No	1	0	7
256	R:R:A311	R:R:I314	4.87	No	Yes	0	4	3
257	R:R:G312	R:R:K315	5.23	No	Yes	0	5	6
258	R:R:K315	R:R:W316	5.8	Yes	No	1	6	6
259	R:R:K315	R:R:Y318	3.58	Yes	Yes	1	6	8
260	R:R:K315	R:R:Q319	14.92	Yes	Yes	1	6	7
261	L:L:S1	R:R:K315	9.18	No	Yes	1	0	6
262	R:R:Q319	R:R:W316	7.67	Yes	No	1	7	6
263	R:R:Q319	R:R:Y318	5.64	Yes	Yes	1	7	8
264	L:L:D7	R:R:Y318	9.2	Yes	Yes	1	0	8
265	L:L:R11	R:R:Y318	9.26	Yes	Yes	1	0	8
266	L:L:A3	R:R:Q319	3.03	No	Yes	0	0	7
267	L:L:L4	R:R:I322	5.71	No	Yes	1	0	8
268	L:L:A3	R:R:L323	4.73	No	No	0	0	5
269	R:R:I326	R:R:I377	2.94	No	No	0	7	6
270	R:R:F372	R:R:N329	6.04	Yes	No	0	9	9
271	R:R:F330	R:R:L334	9.74	Yes	No	0	7	5
272	R:R:F330	R:R:I377	13.82	Yes	No	0	7	6
273	R:R:F333	R:R:V337	7.87	Yes	No	0	9	7
274	R:R:F333	R:R:L368	7.31	Yes	Yes	3	9	9
275	R:R:F333	R:R:V369	3.93	Yes	No	3	9	8
276	R:R:F333	R:R:F372	10.72	Yes	Yes	3	9	9
277	R:R:F333	R:R:V374	10.49	Yes	Yes	3	9	7
278	R:R:N335	R:R:R338	9.64	No	No	0	8	8
279	R:R:L368	R:R:T336	5.9	Yes	No	3	9	9
280	R:R:F372	R:R:T336	7.78	Yes	No	3	9	9
281	R:R:R338	R:R:V339	3.92	No	No	0	8	8
282	R:R:I344	R:R:L361	4.28	No	No	0	8	9
283	R:R:K360	R:R:S364	4.59	No	No	0	8	9
284	R:R:L361	R:R:T365	2.95	No	No	0	9	9
285	R:R:I412	R:R:V367	3.07	No	No	0	8	8
286	R:R:F372	R:R:L368	6.09	Yes	Yes	3	9	9
287	R:R:V369	R:R:V374	9.62	No	Yes	3	8	7
288	R:R:I412	R:R:L370	4.28	No	No	0	8	9
289	R:R:V371	R:R:Y413	8.83	No	No	0	9	9
290	R:R:G373	R:R:H375	3.18	No	Yes	0	9	8
291	R:R:H375	R:R:Y376	18.51	Yes	Yes	1	8	8
292	R:R:H375	R:R:Q405	9.89	Yes	No	1	8	9
293	R:R:N402	R:R:Y376	5.81	No	Yes	0	7	8
294	R:R:Q405	R:R:Y376	11.27	No	Yes	1	9	8
295	R:R:C397	R:R:F379	4.19	No	Yes	0	4	7
296	R:R:E398	R:R:F379	5.83	No	Yes	0	8	7
297	R:R:F379	R:R:F401	7.5	Yes	No	0	7	6
298	R:R:L382	R:R:P383	4.93	No	No	0	6	8
299	R:R:M395	R:R:W391	4.65	Yes	No	0	7	5
300	L:L:E12	R:R:W391	4.36	No	No	0	0	5
301	R:R:E398	R:R:R394	15.12	No	No	0	8	7
302	R:R:L399	R:R:M395	4.24	No	Yes	0	8	7
303	L:L:A5	R:R:E398	6.03	No	No	0	0	8
304	L:L:D6	R:R:L399	4.07	Yes	No	0	0	8
305	R:R:F400	R:R:F404	8.57	No	Yes	0	5	7
306	R:R:F404	R:R:S403	6.61	Yes	No	1	7	9
307	R:R:F404	R:R:F408	3.22	Yes	No	0	7	6
308	R:R:F407	R:R:I411	8.79	No	No	0	6	5
309	R:R:I411	R:R:Y415	8.46	No	No	0	5	8
310	R:R:I412	R:R:Y413	4.84	No	No	0	8	9
311	R:R:N417	R:R:V420	7.39	No	No	0	9	9
312	L:L:R11	L:L:S1	3.95	Yes	No	1	0	0
313	L:L:D7	L:L:R11	16.68	Yes	Yes	1	0	0
314	L:L:E12	L:L:R15	11.63	No	No	0	0	0
315	L:L:L17	L:L:R13	4.86	No	No	0	0	0
316	L:L:L33	L:L:Y29	11.72	No	No	0	0	0
317	R:R:I133	R:R:K137	2.91	No	No	0	2	3
318	R:R:W67	R:R:Y89	2.89	Yes	Yes	0	7	5
319	R:R:W345	R:R:Y358	2.89	No	No	0	6	7
320	R:R:P65	R:R:R75	2.88	No	Yes	0	4	4
321	L:L:L2	R:R:K315	2.82	No	Yes	0	0	6
322	R:R:E346	R:R:T342	2.82	No	No	0	7	7
323	R:R:A191	R:R:F156	2.77	No	Yes	0	8	6
324	R:R:A162	R:R:F184	2.77	No	Yes	0	9	9
325	R:R:H204	R:R:V200	2.77	Yes	No	0	4	6
326	R:R:A302	R:R:R298	2.77	No	Yes	0	5	8
327	R:R:I344	R:R:Q357	2.74	No	No	0	8	7
328	R:R:A99	R:R:Y122	2.67	No	Yes	0	7	5
329	R:R:A288	R:R:Y245	2.67	No	Yes	0	4	9
330	R:R:L40	R:R:Q37	2.66	No	Yes	0	3	7
331	R:R:F169	R:R:V424	2.62	Yes	No	0	7	6
332	R:R:F330	R:R:V374	2.62	Yes	Yes	0	7	7
333	R:R:F111	R:R:T118	2.59	No	No	0	1	6
334	R:R:F195	R:R:T149	2.59	No	No	0	8	7
335	R:R:A295	R:R:W307	2.59	No	Yes	0	6	8
336	R:R:A299	R:R:W307	2.59	No	Yes	0	4	8
337	R:R:F184	R:R:I166	2.51	Yes	No	0	9	8
338	R:R:T354	R:R:Y358	2.5	No	No	0	7	7
339	R:R:V241	R:R:W307	2.45	No	Yes	0	7	8
340	R:R:N417	R:R:R176	2.41	No	Yes	0	9	9
341	R:R:F379	R:R:H375	2.26	Yes	Yes	0	7	8
342	R:R:H102	R:R:W119	2.12	No	No	0	3	5
343	R:R:C63	R:R:G107	1.96	No	No	0	9	9
344	R:R:C86	R:R:G97	1.96	No	No	0	9	5
345	R:R:P87	R:R:P88	1.95	Yes	No	0	8	3
346	R:R:A288	R:R:G285	1.95	No	No	0	4	7
347	R:R:A320	R:R:P321	1.87	No	No	0	6	9
348	R:R:W428	R:R:W431	1.87	No	No	0	5	5
349	R:R:G79	R:R:V78	1.84	No	No	0	7	7
350	R:R:P105	R:R:V78	1.77	No	No	0	1	7
351	R:R:G235	R:R:I234	1.76	No	No	12	4	4
352	R:R:G235	R:R:I238	1.76	No	No	12	4	4
353	R:R:G390	R:R:I393	1.76	No	No	0	4	6
354	R:R:G167	R:R:M181	1.75	No	No	0	4	7
355	R:R:G278	R:R:L281	1.71	No	No	0	3	4
356	R:R:G107	R:R:N104	1.7	No	Yes	0	9	5
357	R:R:G418	R:R:N417	1.7	No	No	0	6	9
358	R:R:E58	R:R:G59	1.64	No	No	0	1	1
359	R:R:C381	R:R:I377	1.64	No	No	0	5	6
360	R:R:C397	R:R:I393	1.64	No	No	0	4	6
361	R:R:C416	R:R:I411	1.64	No	No	0	6	5
362	R:R:N104	R:R:P105	1.63	Yes	No	0	5	1
363	R:R:A297	R:R:I317	1.62	No	No	0	5	9
364	L:L:A8	R:R:M395	1.61	No	Yes	0	0	7
365	L:L:A9	R:R:M395	1.61	No	Yes	0	0	7
366	R:R:V196	R:R:V200	1.6	No	No	0	7	6
367	R:R:V374	R:R:V378	1.6	Yes	No	0	7	6
368	R:R:G167	R:R:H173	1.59	No	No	0	4	8
369	R:R:T300	R:R:V296	1.59	No	No	0	3	5
370	R:R:P131	R:R:Q130	1.58	No	No	0	2	3
371	L:L:A18	R:R:L309	1.58	No	No	0	0	5
372	R:R:C174	R:R:N177	1.57	No	No	0	9	9
373	R:R:T175	R:R:T273	1.57	Yes	No	0	8	5
374	R:R:A54	R:R:N51	1.56	No	No	0	2	4
375	R:R:I205	R:R:S231	1.55	No	No	0	4	4
376	R:R:I154	R:R:V150	1.54	No	No	0	4	6
377	L:L:K32	L:L:S28	1.53	No	No	0	0	0
378	R:R:I34	R:R:T33	1.52	No	Yes	0	3	7
379	R:R:A54	R:R:Q55	1.52	No	No	0	2	1
380	R:R:K343	R:R:V339	1.52	No	No	0	9	8
381	R:R:K363	R:R:V367	1.52	No	No	0	8	8
382	R:R:F156	R:R:G157	1.51	Yes	No	0	6	4
383	R:R:F330	R:R:G327	1.51	Yes	No	0	7	4
384	R:R:L340	R:R:S364	1.5	No	No	0	9	9
385	R:R:L433	R:R:S429	1.5	No	No	0	4	4
386	R:R:F64	R:R:P65	1.44	No	No	0	4	4
387	R:R:K117	R:R:M112	1.44	No	No	0	4	4
388	R:R:Q37	R:R:V41	1.43	Yes	No	0	7	5
389	R:R:I38	R:R:L42	1.43	No	No	0	5	2
390	R:R:I38	R:R:L210	1.43	No	No	0	5	4
391	R:R:I344	R:R:L340	1.43	No	No	0	8	9
392	R:R:I393	R:R:L389	1.43	No	No	0	6	1
393	R:R:A268	R:R:F269	1.39	No	No	0	7	7
394	R:R:A304	R:R:R298	1.38	No	Yes	0	4	8
395	R:R:L340	R:R:L368	1.38	No	Yes	0	9	9
396	R:R:D353	R:R:K356	1.38	No	No	0	7	5
397	L:L:A19	L:L:R22	1.38	No	Yes	0	0	0
398	R:R:I135	R:R:Q138	1.37	No	No	0	1	2
399	L:L:K32	R:R:E209	1.35	No	No	0	0	4
400	R:R:E346	R:R:K343	1.35	No	No	0	7	9
401	R:R:D303	R:R:Q232	1.31	No	No	0	7	6
402	R:R:A341	R:R:W345	1.3	No	No	0	6	6
403	R:R:R355	R:R:T354	1.29	No	No	0	6	7
404	R:R:F379	R:R:L382	1.22	Yes	No	0	7	6
405	R:R:Q55	R:R:R75	1.17	No	Yes	0	1	4
406	R:R:H202	R:R:R199	1.13	No	No	0	5	4
407	R:R:H204	R:R:Y233	1.09	Yes	No	0	4	5
408	L:L:W25	R:R:E209	1.09	Yes	No	0	0	4
409	L:L:W25	L:L:Y29	0.96	Yes	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T33	3.5125	4	0	7
2	R:R:Q37	2.9275	4	0	7
3	R:R:E66	10.0175	4	2	6
4	R:R:W67	7.256	5	8	7
5	R:R:I71	5.52	4	2	5
6	R:R:W73	8.82	6	2	9
7	R:R:R75	4.5	4	0	4
8	R:R:V84	3.7575	4	2	5
9	R:R:P87	4.33	5	2	8
10	R:R:Y89	4.99	4	0	5
11	R:R:F93	7.66167	6	2	5
12	R:R:F100	4.025	4	9	4
13	R:R:R101	8.55429	7	2	8
14	R:R:N104	4.004	5	0	5
15	R:R:W109	9.71	4	2	9
16	R:R:Y122	5.512	5	2	5
17	R:R:F140	10.2675	4	0	5
18	R:R:F141	6.115	4	0	5
19	R:R:Y152	6.304	5	1	8
20	R:R:F156	4.22	4	0	6
21	R:R:F169	4.53333	6	10	7
22	R:R:T175	4.25	4	4	8
23	R:R:R176	5.5975	4	0	9
24	R:R:F184	4.25333	6	5	9
25	R:R:F187	7.17333	6	5	8
26	R:R:R190	6.114	5	1	8
27	R:R:K197	10.56	4	1	7
28	R:R:H204	4	4	0	4
29	R:R:F243	8.884	5	1	6
30	R:R:I244	6.1625	4	1	7
31	R:R:Y245	6.424	5	6	9
32	R:R:F246	7.13	5	6	5
33	R:R:T249	5.8725	4	6	8
34	R:R:Y251	7.746	5	1	7
35	R:R:Y252	7.3625	4	1	5
36	R:R:W253	7.788	5	0	9
37	R:R:Y260	7.00333	6	4	9
38	R:R:H262	11.3925	4	3	9
39	R:R:F270	7.414	5	4	6
40	R:R:F290	5.336	5	1	5
41	R:R:W294	6.61333	6	1	8
42	R:R:R298	7.98	5	1	8
43	R:R:R305	6.205	4	0	5
44	R:R:W307	10.29	7	1	8
45	R:R:E308	4.6825	4	0	6
46	R:R:I314	4.4025	4	1	3
47	R:R:K315	6.92167	6	1	6
48	R:R:Y318	7.47	6	1	8
49	R:R:Q319	7.815	4	1	7
50	R:R:I322	4.4025	4	1	8
51	R:R:F330	6.9225	4	0	7
52	R:R:F333	8.064	5	3	9
53	R:R:L368	5.17	4	3	9
54	R:R:F372	6.67	6	3	9
55	R:R:V374	6.0825	4	3	7
56	R:R:H375	8.46	4	1	8
57	R:R:Y376	12.87	4	1	8
58	R:R:F379	4.2	5	0	7
59	R:R:M395	3.0275	4	0	7
60	R:R:F404	5.888	5	1	7
61	L:L:D6	6.416	5	1	0
62	L:L:D7	9.3125	4	1	0
63	L:L:F10	8.175	4	1	0
64	L:L:R11	8.46	4	1	0
65	L:L:R22	5.64833	6	7	0
66	L:L:W25	3.4475	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L399	R:R:M395	11.5126	4.24	No	Yes	0	8	7
2	L:L:D6	R:R:L399	22.3023	4.07	Yes	No	0	0	8
3	L:L:D6	R:R:F243	91.4909	10.75	Yes	Yes	1	0	6
4	L:L:F10	R:R:F243	96.011	5.36	Yes	Yes	1	0	6
5	L:L:F10	R:R:E308	99.1218	4.66	Yes	Yes	0	0	6
6	R:R:E308	R:R:R305	99.6871	3.49	Yes	Yes	0	6	5
7	R:R:R305	R:R:T33	99.879	3.88	Yes	Yes	0	5	7
8	R:R:I34	R:R:T33	99.9612	1.52	No	Yes	0	3	7
9	L:L:R22	R:R:I34	100	3.76	Yes	No	0	0	3
10	L:L:R22	R:R:Q37	99.8721	3.5	Yes	Yes	0	0	7
11	R:R:I90	R:R:Q37	99.7864	4.12	No	Yes	0	6	7
12	R:R:I90	R:R:Y89	34.483	4.84	No	Yes	0	6	5
13	R:R:P87	R:R:Y89	32.7243	5.56	Yes	Yes	0	8	5
14	R:R:I71	R:R:P87	63.3564	5.08	Yes	Yes	2	5	8
15	R:R:I71	R:R:W73	89.562	8.22	Yes	Yes	2	5	9
16	R:R:E66	R:R:W73	39.5523	4.36	Yes	Yes	2	6	9
17	R:R:E66	R:R:W109	38.5302	14.17	Yes	Yes	2	6	9
18	R:R:C63	R:R:W109	72.9972	10.45	No	Yes	0	9	9
19	R:R:C63	R:R:G107	68.6439	1.96	No	No	0	9	9
20	R:R:G107	R:R:N104	66.4638	1.7	No	Yes	0	9	5
21	R:R:N104	R:R:P105	31.2716	1.63	Yes	No	0	5	1
22	R:R:P105	R:R:V78	29.0527	1.77	No	No	0	1	7
23	R:R:N62	R:R:V78	24.608	4.43	No	No	0	3	7
24	R:R:E60	R:R:N62	22.3822	15.77	No	No	0	3	3
25	R:R:E60	R:R:R75	17.9238	9.3	No	Yes	0	3	4
26	R:R:F93	R:R:I90	65.3629	16.33	Yes	No	0	5	6
27	R:R:F93	R:R:P87	32.6089	5.78	Yes	Yes	2	5	8
28	R:R:F93	R:R:L70	31.8232	6.09	Yes	No	2	5	6
29	R:R:I71	R:R:L70	31.5697	5.71	Yes	No	2	5	6
30	R:R:R101	R:R:W73	43.9354	21.99	Yes	Yes	2	8	9
31	R:R:R101	R:R:W109	38.81	10	Yes	Yes	2	8	9
32	R:R:D110	R:R:N104	29.0527	5.39	No	Yes	0	4	5
33	R:R:D110	R:R:H102	26.8315	8.82	No	No	0	4	3
34	R:R:H102	R:R:I81	17.9238	5.3	No	No	0	3	4
35	R:R:F100	R:R:I81	15.6912	3.77	Yes	No	0	4	4
36	R:R:L144	R:R:L399	10.2358	5.54	No	No	0	6	8
37	L:L:D6	R:R:R190	76.4609	4.76	Yes	Yes	1	0	8
38	R:R:N250	R:R:R190	49.0093	9.64	No	Yes	0	9	8
39	R:R:F187	R:R:N250	29.5677	8.46	Yes	No	0	8	9
40	R:R:F184	R:R:F187	14.8164	4.29	Yes	Yes	5	9	8
41	R:R:N250	R:R:S186	23.45	4.47	No	No	0	9	9
42	R:R:S186	R:R:W253	16.0372	3.71	No	Yes	0	9	9
43	R:R:F187	R:R:L183	10.0657	9.74	Yes	No	5	8	9
44	R:R:E257	R:R:L183	10.0474	10.6	No	No	0	9	9
45	R:R:R190	R:R:Y251	45.0214	5.14	Yes	Yes	1	8	7
46	R:R:F243	R:R:I244	17.0502	3.77	Yes	Yes	1	6	7
47	R:R:I244	R:R:W294	10.7737	8.22	Yes	Yes	1	7	8
48	R:R:I322	R:R:Y251	35.7095	3.63	Yes	Yes	1	8	7
49	R:R:Y251	R:R:Y376	10.4871	15.89	Yes	Yes	1	7	8
50	R:R:F290	R:R:I322	34.6942	5.02	Yes	Yes	1	5	8
51	R:R:F290	R:R:Y252	31.8289	6.19	Yes	Yes	1	5	5
52	R:R:A325	R:R:Y252	31.3915	6.67	No	Yes	0	7	5
53	R:R:A325	R:R:L255	30.8331	4.73	No	No	0	7	8
54	R:R:L255	R:R:L259	29.7094	6.92	No	No	0	8	7
55	R:R:L259	R:R:L332	29.1441	5.54	No	No	0	7	8
56	R:R:H262	R:R:L332	28.5765	14.14	Yes	No	0	9	8
57	R:R:H262	R:R:T336	23.1542	4.11	Yes	No	3	9	9
58	R:R:F372	R:R:T336	10.6572	7.78	Yes	No	3	9	9
59	R:R:L368	R:R:T336	11.9112	5.9	Yes	No	3	9	9
60	R:R:F333	R:R:V374	10.2221	10.49	Yes	Yes	3	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R15	R:R:T31	3.88	0	No	No	0	5	0	1
L:L:R22	R:R:I32	3.76	7	Yes	No	0	4	0	1
R:R:R305	R:R:T33	3.88	0	Yes	Yes	5	7	1	2
R:R:L309	R:R:T33	4.42	0	No	Yes	5	7	1	2
L:L:R22	R:R:I34	3.76	7	Yes	No	0	3	0	1
L:L:W25	R:R:I34	5.87	0	Yes	No	0	3	0	1
R:R:E35	R:R:R305	11.63	0	No	Yes	6	5	2	1
R:R:I90	R:R:Q37	4.12	0	No	Yes	6	7	2	1
L:L:R22	R:R:Q37	3.5	7	Yes	Yes	0	7	0	1
L:L:W25	R:R:I38	5.87	0	Yes	No	0	5	0	1
R:R:L70	R:R:P87	3.28	2	No	Yes	6	8	2	2
R:R:F93	R:R:L70	6.09	2	Yes	No	5	6	1	2
R:R:R101	R:R:W73	21.99	2	Yes	Yes	8	9	2	2
R:R:W73	R:R:Y122	6.75	2	Yes	Yes	9	5	2	1
R:R:F93	R:R:P87	5.78	2	Yes	Yes	5	8	1	2
R:R:F93	R:R:I90	16.33	2	Yes	No	5	6	1	2
R:R:D92	R:R:Y91	5.75	7	No	No	4	4	1	1
L:L:R22	R:R:Y91	7.2	7	Yes	No	0	4	0	1
L:L:R22	R:R:D92	14.29	7	Yes	No	0	4	0	1
L:L:R23	R:R:D92	20.25	0	No	No	0	4	0	1
R:R:C125	R:R:F93	5.59	0	No	Yes	9	5	2	1
R:R:F93	R:R:L126	4.87	2	Yes	No	5	3	1	2
L:L:L26	R:R:F93	7.31	0	No	Yes	0	5	0	1
R:R:A120	R:R:R101	4.15	2	No	Yes	7	8	2	2
R:R:R101	R:R:Y122	3.09	2	Yes	Yes	8	5	2	1
R:R:A120	R:R:Y122	6.67	2	No	Yes	7	5	2	1
L:L:M30	R:R:Y122	8.38	0	No	Yes	0	5	0	1
L:L:R23	R:R:Q130	12.85	0	No	No	0	3	0	1
L:L:L16	R:R:S134	3	0	No	No	0	3	0	1
L:L:L20	R:R:S134	6.01	0	No	No	0	3	0	1
L:L:L16	R:R:K137	5.64	0	No	No	0	3	0	1
L:L:L20	R:R:Q138	3.99	0	No	No	0	2	0	1
R:R:F140	R:R:F141	3.22	0	Yes	Yes	5	5	2	1
L:L:E12	R:R:F141	5.83	0	No	Yes	0	5	0	1
L:L:R13	R:R:F141	11.76	0	No	Yes	0	5	0	1
L:L:L16	R:R:F141	3.65	0	No	Yes	0	5	0	1
L:L:R13	R:R:E142	3.49	0	No	No	0	2	0	1
R:R:L144	R:R:L399	5.54	0	No	No	6	8	2	1
R:R:Y148	R:R:Y152	4.96	1	No	Yes	7	8	2	1
R:R:D198	R:R:Y148	5.75	1	No	No	8	7	2	2
R:R:R190	R:R:Y152	6.17	1	Yes	Yes	8	8	1	1
R:R:I194	R:R:Y152	9.67	1	No	Yes	7	8	1	1
R:R:S403	R:R:Y152	3.82	1	No	Yes	9	8	2	1
L:L:D6	R:R:Y152	6.9	1	Yes	Yes	0	8	0	1
R:R:L247	R:R:R190	4.86	1	No	Yes	6	8	2	1
R:R:N250	R:R:R190	9.64	0	No	Yes	9	8	2	1
R:R:R190	R:R:Y251	5.14	1	Yes	Yes	8	7	1	1
L:L:D6	R:R:R190	4.76	1	Yes	Yes	0	8	0	1
L:L:D6	R:R:I194	5.6	1	Yes	No	0	7	0	1
R:R:D198	R:R:K197	5.53	1	No	Yes	8	7	2	1
R:R:A239	R:R:K197	3.21	0	No	Yes	7	7	2	1
R:R:F243	R:R:K197	17.37	1	Yes	Yes	6	7	1	1
L:L:F10	R:R:K197	16.13	1	Yes	Yes	0	7	0	1
L:L:F10	R:R:V201	6.55	1	Yes	No	0	6	0	1
L:L:E21	R:R:I205	4.1	0	No	No	0	4	0	1
R:R:F243	R:R:I244	3.77	1	Yes	Yes	6	7	1	1
L:L:D6	R:R:F243	10.75	1	Yes	Yes	0	6	0	1
L:L:D7	R:R:F243	7.17	1	Yes	Yes	0	6	0	1
L:L:F10	R:R:F243	5.36	1	Yes	Yes	0	6	0	1
R:R:I244	R:R:W294	8.22	1	Yes	Yes	7	8	1	2
R:R:I244	R:R:Y318	8.46	1	Yes	Yes	7	8	1	1
L:L:D7	R:R:I244	4.2	1	Yes	Yes	0	7	0	1
R:R:L247	R:R:Y251	10.55	1	No	Yes	6	7	2	1
R:R:A248	R:R:I322	3.25	0	No	Yes	7	8	2	1
R:R:I322	R:R:Y251	3.63	1	Yes	Yes	8	7	1	1
R:R:Y251	R:R:Y376	15.89	1	Yes	Yes	7	8	1	2
L:L:L4	R:R:Y251	3.52	1	No	Yes	0	7	0	1
R:R:F290	R:R:I322	5.02	1	Yes	Yes	5	8	2	1
R:R:W294	R:R:Y318	8.68	1	Yes	Yes	8	8	2	1
R:R:E308	R:R:R305	3.49	0	Yes	Yes	6	5	1	1
L:L:E21	R:R:R305	5.82	0	No	Yes	0	5	0	1
R:R:C306	R:R:E308	3.04	0	No	Yes	9	6	2	1
L:L:F10	R:R:E308	4.66	1	Yes	Yes	0	6	0	1
L:L:A14	R:R:E308	7.54	0	No	Yes	0	6	0	1
L:L:S1	R:R:S310	4.89	1	No	No	0	7	0	1
L:L:R11	R:R:S310	3.95	1	Yes	No	0	7	0	1
R:R:G312	R:R:K315	5.23	0	No	Yes	5	6	2	1
R:R:K315	R:R:W316	5.8	1	Yes	No	6	6	1	2
R:R:K315	R:R:Y318	3.58	1	Yes	Yes	6	8	1	1
R:R:K315	R:R:Q319	14.92	1	Yes	Yes	6	7	1	1
L:L:S1	R:R:K315	9.18	1	No	Yes	0	6	0	1
R:R:Q319	R:R:W316	7.67	1	Yes	No	7	6	1	2
R:R:Q319	R:R:Y318	5.64	1	Yes	Yes	7	8	1	1
L:L:D7	R:R:Y318	9.2	1	Yes	Yes	0	8	0	1
L:L:R11	R:R:Y318	9.26	1	Yes	Yes	0	8	0	1
L:L:A3	R:R:Q319	3.03	0	No	Yes	0	7	0	1
L:L:L4	R:R:I322	5.71	1	No	Yes	0	8	0	1
L:L:A3	R:R:L323	4.73	0	No	No	0	5	0	1
R:R:E398	R:R:F379	5.83	0	No	Yes	8	7	1	2
R:R:M395	R:R:W391	4.65	0	Yes	No	7	5	1	1
L:L:E12	R:R:W391	4.36	0	No	No	0	5	0	1
R:R:E398	R:R:R394	15.12	0	No	No	8	7	1	2
R:R:L399	R:R:M395	4.24	0	No	Yes	8	7	1	1
L:L:A5	R:R:E398	6.03	0	No	No	0	8	0	1
L:L:D6	R:R:L399	4.07	1	Yes	No	0	8	0	1
R:R:I133	R:R:K137	2.91	0	No	No	2	3	2	1
L:L:L2	R:R:K315	2.82	0	No	Yes	0	6	0	1
R:R:A99	R:R:Y122	2.67	0	No	Yes	7	5	2	1
R:R:L40	R:R:Q37	2.66	0	No	Yes	3	7	2	1
L:L:A8	R:R:M395	1.61	0	No	Yes	0	7	0	1
L:L:A9	R:R:M395	1.61	0	No	Yes	0	7	0	1
R:R:P131	R:R:Q130	1.58	0	No	No	2	3	2	1
L:L:A18	R:R:L309	1.58	0	No	No	0	5	0	1
R:R:I205	R:R:S231	1.55	0	No	No	4	4	1	2
R:R:I34	R:R:T33	1.52	0	No	Yes	3	7	1	2
R:R:Q37	R:R:V41	1.43	0	Yes	No	7	5	1	2
R:R:I38	R:R:L42	1.43	0	No	No	5	2	1	2
R:R:I38	R:R:L210	1.43	0	No	No	5	4	1	2
R:R:I135	R:R:Q138	1.37	0	No	No	1	2	2	1
L:L:K32	R:R:E209	1.35	0	No	No	0	4	0	1
L:L:W25	R:R:E209	1.09	0	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F16_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	366
Number of Links	409
Number of Hubs	66
Number of Links mediated by Hubs	249
Number of Communities	12
Number of Nodes involved in Communities	90
Number of Links involved in Communities	126

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	138254
Length Of Smallest Path	3
Average Path Length	21.1015
Length of Longest Path	44
Minimum Path Strength	1.025
Average Path Strength	6.18564
Maximum Path Strength	27.08
Minimum Path Correlation	0.7
Average Path Correlation	0.960456
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	62.4523
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	59.8026
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • regulation of biological process • regulation of cellular process • homeostatic process • biological regulation • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • cellular process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • cell surface receptor signaling pathway • response to stimulus • signaling • signal transduction • cell communication • G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • neuropeptide signaling pathway • extracellular region • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49190
Sequence	>7F16_nogp_Chain_R T I T I E E Q I V L V L K A K V Q C E L N I T A Q L Q E G E G N C F P E W D G L I C W P R G T V G K I S A V P C P P Y I Y D F N H K G V A F R H C N P N G T W D F M H S L N K T W A N Y S D C L R F L Q P D I S I G K Q E F F E R L Y V M Y T V G Y S I S F G S L A V A I L I I G Y F R R L H C T R N Y I H M H L F V S F M L R A T S I F V K D R V V H A H I G V K E L E S Q Y I G C K I A V V M F I Y F L A T N Y Y W I L V E G L Y L H N L I F V A F F S D T K Y L W G F I L I G W G F P A A F V A A W A V A R A T L A D A R C W E L S A G D I K W I Y Q A P I L A A I G L N F I L F L N T V R V L A T K I W E T D T R K Q Y R K L A K S T L V L V L V F G V H Y I V F V C L P G L G W E I R M H C E L F F N S F Q G F F V S I I Y C Y C N G E V Q A E V K K M W S R W N L S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F16	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-	Gs/β1/γ2	2.8	2021-08-18	10.1073/pnas.2101279118
	7F16 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-		2.8	2021-08-18	10.1073/pnas.2101279118

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