psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q20	L:L:S19	10.11	No	No	0	0	0
2	L:L:V21	L:L:Y46	5.05	No	Yes	3	0	0
3	L:L:R117	L:L:V21	3.92	Yes	No	3	0	0
4	L:L:V21	L:L:Y131	11.36	No	No	3	0	0
5	L:L:C41	L:L:L23	4.76	No	No	3	0	0
6	L:L:C115	L:L:L23	3.17	Yes	No	3	0	0
7	L:L:L23	L:L:R117	3.64	No	Yes	3	0	0
8	L:L:Q134	L:L:Q24	10.24	No	No	0	0	0
9	L:L:C41	L:L:Q25	6.1	No	Yes	3	0	0
10	L:L:C115	L:L:Q25	6.1	Yes	Yes	3	0	0
11	L:L:G133	L:L:Q25	3.29	No	Yes	0	0	0
12	L:L:Q134	L:L:Q25	6.4	No	Yes	0	0	0
13	L:L:G135	L:L:Q25	3.29	No	Yes	0	0	0
14	L:L:Q25	L:L:V136	7.16	Yes	No	0	0	0
15	L:L:G27	L:L:S26	3.71	No	No	0	0	0
16	L:L:S26	L:L:V136	3.23	No	No	0	0	0
17	L:L:A28	L:L:M137	3.22	No	No	0	0	0
18	L:L:E29	L:L:V37	2.85	No	No	0	0	0
19	L:L:L30	L:L:T139	2.95	No	No	0	0	0
20	L:L:F175	L:L:L30	6.09	Yes	No	0	0	0
21	L:L:K32	L:L:S35	3.06	No	No	0	0	0
22	L:L:P33	L:L:V140	3.53	No	No	0	0	0
23	L:L:P33	L:L:S142	3.56	No	No	0	0	0
24	L:L:Q101	L:L:S36	5.78	No	No	0	0	0
25	L:L:L102	L:L:V37	4.47	Yes	No	3	0	0
26	L:L:L105	L:L:V37	2.98	Yes	No	3	0	0
27	L:L:F99	L:L:K38	12.41	Yes	No	0	0	0
28	L:L:K38	L:L:Q101	2.71	No	No	0	0	0
29	L:L:I39	L:L:W55	8.22	Yes	Yes	3	0	0
30	L:L:I39	L:L:M100	7.29	Yes	Yes	3	0	0
31	L:L:I39	L:L:L102	2.85	Yes	Yes	3	0	0
32	L:L:I39	L:L:Y113	3.63	Yes	Yes	3	0	0
33	L:L:I39	L:L:V136	3.07	Yes	No	0	0	0
34	L:L:C115	L:L:C41	7.28	Yes	No	3	0	0
35	L:L:K42	L:L:T97	4.5	No	No	0	0	0
36	L:L:A43	L:L:Y46	4	No	Yes	0	0	0
37	L:L:A43	L:L:F48	2.77	No	Yes	0	0	0
38	L:L:Y46	L:L:Y51	5.96	Yes	Yes	3	0	0
39	L:L:R117	L:L:Y46	14.4	Yes	Yes	3	0	0
40	L:L:S50	L:L:T47	6.4	No	No	0	0	0
41	L:L:F48	L:L:I53	3.77	Yes	No	0	0	0
42	L:L:F48	L:L:P72	14.45	Yes	No	0	0	0
43	L:L:F48	L:L:S96	6.61	Yes	No	0	0	0
44	L:L:S50	L:L:Y51	3.82	No	Yes	0	0	0
45	L:L:R117	L:L:Y51	15.43	Yes	Yes	3	0	0
46	L:L:F69	L:L:Y52	7.22	Yes	Yes	1	0	0
47	L:L:N71	L:L:Y52	12.79	Yes	Yes	1	0	0
48	L:L:G120	L:L:Y52	2.9	No	Yes	1	0	0
49	L:L:I125	L:L:Y52	8.46	Yes	Yes	1	0	0
50	L:L:I126	L:L:Y52	9.67	No	Yes	1	0	0
51	L:L:Y52	R:R:E43	6.73	Yes	Yes	1	0	5
52	L:L:Y52	R:R:R117	10.29	Yes	Yes	1	0	6
53	L:L:A98	L:L:I53	4.87	No	No	0	0	0
54	L:L:I56	L:L:S54	3.1	No	No	0	0	0
55	L:L:F129	L:L:S54	5.28	Yes	No	0	0	0
56	L:L:L89	L:L:W55	5.69	Yes	Yes	3	0	0
57	L:L:M100	L:L:W55	18.61	Yes	Yes	3	0	0
58	L:L:C115	L:L:W55	7.84	Yes	Yes	3	0	0
59	L:L:I56	L:L:W132	4.7	No	Yes	0	0	0
60	L:L:I56	N:N:F384	6.28	No	No	0	0	0
61	L:L:K57	L:L:T59	3	Yes	No	3	0	0
62	L:L:I67	L:L:K57	5.82	Yes	Yes	3	0	0
63	L:L:F83	L:L:K57	8.69	No	Yes	3	0	0
64	L:L:D108	L:L:K57	2.77	No	Yes	0	0	0
65	L:L:A111	L:L:K57	4.82	No	Yes	3	0	0
66	L:L:K57	L:L:Y113	11.94	Yes	Yes	3	0	0
67	L:L:L64	L:L:Q58	11.98	No	No	0	0	0
68	L:L:Q58	L:L:Y114	7.89	No	Yes	1	0	0
69	L:L:Q58	N:N:Q324	8.96	No	Yes	1	0	0
70	L:L:Q62	L:L:T59	8.5	No	No	0	0	0
71	L:L:A111	L:L:T59	3.36	No	No	3	0	0
72	L:L:G61	L:L:Q62	3.29	No	No	0	0	0
73	L:L:L64	N:N:Y373	8.21	No	Yes	0	0	0
74	L:L:L64	N:N:F384	14.61	No	No	0	0	0
75	L:L:K65	L:L:K82	2.87	No	No	0	0	0
76	L:L:G68	L:L:Y66	7.24	No	Yes	0	0	0
77	L:L:F69	L:L:Y66	5.16	Yes	Yes	1	0	0
78	L:L:N78	L:L:Y66	4.65	No	Yes	1	0	0
79	L:L:N80	L:L:Y66	5.81	Yes	Yes	0	0	0
80	L:L:Y66	N:N:Y382	20.85	Yes	Yes	1	0	0
81	L:L:G68	L:L:I67	3.53	No	Yes	0	0	0
82	L:L:F83	L:L:I67	17.58	No	Yes	3	0	0
83	L:L:I67	L:L:M100	5.83	Yes	Yes	3	0	0
84	L:L:F69	L:L:H76	3.39	Yes	No	0	0	0
85	L:L:F69	L:L:N78	7.25	Yes	No	1	0	0
86	L:L:F69	L:L:I125	3.77	Yes	Yes	1	0	0
87	L:L:F69	L:L:I126	5.02	Yes	No	1	0	0
88	L:L:F69	N:N:L380	3.65	Yes	No	1	0	0
89	L:L:I70	L:L:T77	7.6	No	No	0	0	0
90	L:L:I70	L:L:L89	7.14	No	Yes	0	0	0
91	L:L:I70	L:L:V91	6.14	No	No	0	0	0
92	L:L:N71	L:L:P72	4.89	Yes	No	0	0	0
93	L:L:N71	L:L:S74	4.47	Yes	No	1	0	0
94	L:L:N71	R:R:E43	9.2	Yes	Yes	1	0	5
95	L:L:N71	R:R:G118	5.09	Yes	No	0	0	7
96	L:L:P72	L:L:V91	7.07	No	No	0	0	0
97	L:L:S74	R:R:E43	8.62	No	Yes	1	0	5
98	L:L:G75	R:R:R40	4.5	No	Yes	0	0	6
99	L:L:H76	R:R:R40	3.39	No	Yes	0	0	6
100	L:L:H76	R:R:E43	11.08	No	Yes	0	0	5
101	L:L:T77	L:L:Y79	9.99	No	Yes	0	0	0
102	L:L:N78	N:N:L380	10.98	No	No	1	0	0
103	L:L:L89	L:L:Y79	11.72	Yes	Yes	0	0	0
104	L:L:K82	L:L:N80	2.8	No	Yes	0	0	0
105	L:L:F83	L:L:N80	4.83	No	Yes	0	0	0
106	L:L:N80	N:N:P381	3.26	Yes	No	0	0	0
107	L:L:E81	L:L:K84	5.4	No	No	0	0	0
108	L:L:D109	L:L:K86	12.44	Yes	No	0	0	0
109	L:L:A87	L:L:M100	3.22	No	Yes	0	0	0
110	L:L:L89	L:L:M100	4.24	Yes	Yes	3	0	0
111	L:L:F99	L:L:T90	3.89	Yes	No	0	0	0
112	L:L:D92	L:L:S94	5.89	No	No	0	0	0
113	L:L:D92	L:L:S95	7.36	No	No	0	0	0
114	L:L:S95	L:L:T97	4.8	No	No	0	0	0
115	L:L:F99	L:L:T97	6.49	Yes	No	0	0	0
116	L:L:L102	L:L:M100	5.65	Yes	Yes	3	0	0
117	L:L:M100	L:L:Y113	3.59	Yes	Yes	3	0	0
118	L:L:L102	L:L:L105	4.15	Yes	Yes	3	0	0
119	L:L:D109	L:L:L105	4.07	Yes	Yes	0	0	0
120	L:L:L105	L:L:V140	7.45	Yes	No	0	0	0
121	L:L:P107	L:L:T106	5.25	No	No	0	0	0
122	L:L:D108	L:L:T106	2.89	No	No	0	0	0
123	L:L:D109	L:L:T106	4.34	Yes	No	0	0	0
124	L:L:D109	L:L:Y113	3.45	Yes	Yes	0	0	0
125	L:L:S110	L:L:V140	3.23	No	No	0	0	0
126	L:L:A111	L:L:Y113	4	No	Yes	3	0	0
127	L:L:I112	L:L:Y114	10.88	No	Yes	0	0	0
128	L:L:I112	L:L:M137	2.92	No	No	0	0	0
129	L:L:V138	L:L:Y113	6.31	No	Yes	0	0	0
130	L:L:W132	L:L:Y114	6.75	Yes	Yes	1	0	0
131	L:L:G135	L:L:Y114	5.79	No	Yes	0	0	0
132	L:L:Y114	N:N:Q324	3.38	Yes	Yes	1	0	0
133	L:L:Y114	N:N:P330	4.17	Yes	Yes	1	0	0
134	L:L:A116	L:L:F129	2.77	No	Yes	0	0	0
135	L:L:A116	L:L:W132	6.48	No	Yes	0	0	0
136	L:L:D130	L:L:R117	14.29	No	Yes	3	0	0
137	L:L:R117	L:L:Y131	4.12	Yes	No	3	0	0
138	L:L:F129	L:L:G118	3.01	Yes	No	0	0	0
139	L:L:G120	R:R:R117	3	No	Yes	1	0	6
140	L:L:G121	L:L:T127	5.46	No	No	0	0	0
141	L:L:F122	L:L:L123	4.87	No	No	0	0	0
142	L:L:F122	R:R:Y114	11.35	No	Yes	0	0	2
143	L:L:L123	N:N:Y318	3.52	No	Yes	0	0	0
144	L:L:R124	N:N:Y318	14.4	No	Yes	0	0	0
145	L:L:R124	N:N:N378	10.85	No	No	0	0	0
146	L:L:R124	R:R:P50	11.53	No	No	0	0	5
147	L:L:I125	R:R:H46	3.98	Yes	Yes	1	0	4
148	L:L:I125	R:R:G47	5.29	Yes	No	0	0	2
149	L:L:F129	L:L:I126	3.77	Yes	No	1	0	0
150	L:L:D130	L:L:K128	9.68	No	No	0	0	0
151	L:L:K128	N:N:Y335	17.91	No	No	0	0	0
152	L:L:K128	N:N:E341	5.4	No	No	0	0	0
153	L:L:F129	N:N:H320	6.79	Yes	Yes	1	0	0
154	L:L:F129	N:N:Y322	4.13	Yes	Yes	1	0	0
155	L:L:F129	N:N:Q375	3.51	Yes	Yes	1	0	0
156	L:L:F129	N:N:Y382	3.09	Yes	Yes	1	0	0
157	L:L:D130	L:L:Y131	4.6	No	No	3	0	0
158	L:L:W132	N:N:Y322	12.54	Yes	Yes	1	0	0
159	L:L:W132	N:N:P330	14.86	Yes	Yes	1	0	0
160	L:L:M137	L:L:T139	3.01	No	No	0	0	0
161	L:L:F175	L:L:S141	5.28	Yes	No	0	0	0
162	L:L:Q144	L:L:T146	5.67	No	No	0	0	0
163	L:L:P176	L:L:T145	3.5	Yes	No	0	0	0
164	L:L:P148	L:L:Y174	6.95	No	Yes	6	0	0
165	L:L:H226	L:L:P148	9.15	Yes	No	6	0	0
166	L:L:S149	L:L:Y151	5.09	No	Yes	0	0	0
167	L:L:V150	L:L:V171	4.81	No	No	0	0	0
168	L:L:V150	L:L:V224	4.81	No	No	13	0	0
169	L:L:V150	L:L:V233	3.21	No	No	13	0	0
170	L:L:Y151	N:N:S407	5.09	Yes	No	11	0	0
171	L:L:Y151	N:N:E409	7.86	Yes	Yes	11	0	0
172	L:L:Y151	N:N:R410	18.52	Yes	Yes	11	0	0
173	L:L:Y151	N:N:T413	6.24	Yes	No	11	0	0
174	L:L:K235	L:L:P152	10.04	No	No	0	0	0
175	L:L:P152	L:L:V237	3.53	No	No	0	0	0
176	L:L:L153	N:N:F404	10.96	No	Yes	0	0	0
177	L:L:P155	N:N:F404	5.78	No	Yes	0	0	0
178	L:L:G156	L:L:S240	3.71	No	No	0	0	0
179	L:L:S162	L:L:T164	4.8	No	No	0	0	0
180	L:L:S163	L:L:T164	4.8	No	No	0	0	0
181	L:L:S163	L:L:S213	3.26	No	No	0	0	0
182	L:L:T166	L:L:T211	3.14	No	No	0	0	0
183	L:L:T166	N:N:S402	6.4	No	No	4	0	0
184	L:L:T166	N:N:F404	6.49	No	Yes	4	0	0
185	L:L:L167	L:L:W215	15.94	No	No	0	0	0
186	L:L:L167	L:L:V220	2.98	No	Yes	0	0	0
187	L:L:G168	L:L:W183	2.81	No	Yes	0	0	0
188	L:L:C169	L:L:C222	7.28	No	No	0	0	0
189	L:L:L170	L:L:T207	2.95	No	No	0	0	0
190	L:L:L170	N:N:S417	3	No	No	0	0	0
191	L:L:L206	L:L:V171	4.47	No	No	0	0	0
192	L:L:K172	L:L:T205	6.01	No	No	0	0	0
193	L:L:K172	N:N:S417	6.12	No	No	0	0	0
194	L:L:G173	L:L:L203	3.42	No	No	0	0	0
195	L:L:E177	L:L:Y174	3.37	Yes	Yes	6	0	0
196	L:L:V179	L:L:Y174	8.83	No	Yes	6	0	0
197	L:L:Y174	L:L:Y204	9.93	Yes	Yes	6	0	0
198	L:L:L206	L:L:Y174	7.03	No	Yes	0	0	0
199	L:L:H226	L:L:Y174	5.44	Yes	Yes	6	0	0
200	L:L:F175	L:L:P176	7.22	Yes	Yes	0	0	0
201	L:L:F175	L:L:Y204	3.09	Yes	Yes	0	0	0
202	L:L:P176	L:L:P178	3.9	Yes	No	0	0	0
203	L:L:H226	L:L:P176	4.58	Yes	Yes	6	0	0
204	L:L:A228	L:L:P176	3.74	No	Yes	6	0	0
205	L:L:E177	L:L:P178	4.72	Yes	No	0	0	0
206	L:L:A197	L:L:E177	3.02	No	Yes	0	0	0
207	L:L:E177	L:L:Y204	11.22	Yes	Yes	6	0	0
208	L:L:H226	L:L:V179	5.54	Yes	No	6	0	0
209	L:L:T194	L:L:V181	4.76	No	No	0	0	0
210	L:L:S208	L:L:V181	6.46	No	No	0	0	0
211	L:L:N223	L:L:T182	4.39	Yes	No	0	0	0
212	L:L:S208	L:L:W183	6.18	No	Yes	0	0	0
213	L:L:V210	L:L:W183	18.39	No	Yes	0	0	0
214	L:L:V220	L:L:W183	3.68	Yes	Yes	0	0	0
215	L:L:C222	L:L:W183	3.92	No	Yes	0	0	0
216	L:L:L188	L:L:N184	9.61	No	Yes	0	0	0
217	L:L:N184	L:L:V220	8.87	Yes	Yes	0	0	0
218	L:L:L188	L:L:S212	3	No	No	0	0	0
219	L:L:D191	L:L:H193	10.08	No	Yes	4	0	0
220	L:L:D191	L:L:T211	8.67	No	No	0	0	0
221	L:L:D191	N:N:N423	4.04	No	Yes	4	0	0
222	L:L:H193	L:L:S209	4.18	Yes	No	0	0	0
223	L:L:H193	N:N:N423	7.65	Yes	Yes	4	0	0
224	L:L:H193	N:N:N424	5.1	Yes	No	4	0	0
225	L:L:H193	N:N:D453	7.56	Yes	No	4	0	0
226	L:L:H193	N:N:S460	15.34	Yes	Yes	4	0	0
227	L:L:L206	L:L:T194	2.95	No	No	0	0	0
228	L:L:F195	L:L:S209	3.96	Yes	No	0	0	0
229	L:L:F195	N:N:S448	5.28	Yes	No	4	0	0
230	L:L:F195	N:N:T450	5.19	Yes	No	4	0	0
231	L:L:F195	N:N:S460	3.96	Yes	Yes	4	0	0
232	L:L:F195	N:N:S462	15.85	Yes	No	4	0	0
233	L:L:P196	N:N:T450	3.5	No	No	0	0	0
234	L:L:V198	N:N:L446	5.96	No	No	0	0	0
235	L:L:G202	L:L:L199	3.42	No	No	0	0	0
236	L:L:L199	L:L:Y204	14.07	No	Yes	0	0	0
237	L:L:Q200	L:L:S201	7.22	No	No	0	0	0
238	L:L:S212	L:L:T214	4.8	No	No	0	0	0
239	L:L:Q218	L:L:T214	17.01	No	No	0	0	0
240	L:L:P216	L:L:W215	13.51	No	No	0	0	0
241	L:L:Q218	L:L:S217	2.89	No	No	0	0	0
242	L:L:K236	L:L:T219	9.01	No	No	0	0	0
243	L:L:V220	L:L:V237	3.21	Yes	No	0	0	0
244	L:L:N223	L:L:T221	8.77	Yes	No	0	0	0
245	L:L:K232	L:L:N223	2.8	No	Yes	14	0	0
246	L:L:D234	L:L:N223	10.77	No	Yes	14	0	0
247	L:L:V224	L:L:V233	3.21	No	No	13	0	0
248	L:L:H226	L:L:P227	6.1	Yes	No	0	0	0
249	L:L:A228	L:L:H226	2.93	No	Yes	6	0	0
250	L:L:H226	L:L:S229	8.37	Yes	No	0	0	0
251	L:L:S229	L:L:T231	6.4	No	No	0	0	0
252	L:L:D234	L:L:K232	11.06	No	No	14	0	0
253	L:L:K235	L:L:V233	3.04	No	No	0	0	0
254	L:L:K236	L:L:V237	4.55	No	No	0	0	0
255	L:L:G238	L:L:K236	3.49	No	No	0	0	0
256	N:N:D288	N:N:P381	4.83	No	No	0	0	0
257	N:N:D288	N:N:T383	4.34	No	No	0	0	0
258	N:N:L291	N:N:T289	2.95	Yes	Yes	7	0	0
259	N:N:K313	N:N:T289	3	No	Yes	7	0	0
260	N:N:Q376	N:N:T289	8.5	Yes	Yes	7	0	0
261	N:N:E379	N:N:T289	7.06	No	Yes	7	0	0
262	N:N:C309	N:N:L291	4.76	No	Yes	7	0	0
263	N:N:A311	N:N:L291	3.15	No	Yes	0	0	0
264	N:N:C374	N:N:L291	6.35	Yes	Yes	7	0	0
265	N:N:L291	N:N:Q376	5.32	Yes	Yes	7	0	0
266	N:N:R310	N:N:T292	3.88	No	No	0	0	0
267	N:N:C309	N:N:Q293	3.05	No	Yes	7	0	0
268	N:N:C374	N:N:Q293	6.1	Yes	Yes	7	0	0
269	N:N:G385	N:N:Q293	3.29	No	Yes	0	0	0
270	N:N:G387	N:N:Q293	4.93	No	Yes	0	0	0
271	N:N:Q293	N:N:T388	8.5	Yes	No	0	0	0
272	N:N:P295	N:N:S294	5.34	No	No	0	0	0
273	N:N:S294	N:N:S308	4.89	No	No	0	0	0
274	N:N:L297	N:N:L390	2.77	No	No	0	0	0
275	N:N:A298	N:N:E391	3.02	No	No	0	0	0
276	N:N:A298	N:N:K393	3.21	No	No	0	0	0
277	N:N:Q303	N:N:V299	2.87	No	No	5	0	0
278	N:N:V299	N:N:V305	3.21	No	No	5	0	0
279	N:N:L390	N:N:V299	5.96	No	No	0	0	0
280	N:N:K393	N:N:S300	9.18	No	No	0	0	0
281	N:N:L301	N:N:P366	3.28	No	No	0	0	0
282	N:N:L301	N:N:L392	2.77	No	No	0	0	0
283	N:N:Q303	N:N:V305	2.87	No	No	5	0	0
284	N:N:K393	N:N:Q303	2.71	No	No	0	0	0
285	N:N:R304	N:N:T360	6.47	No	Yes	15	0	0
286	N:N:D362	N:N:R304	9.53	No	No	15	0	0
287	N:N:I361	N:N:V305	4.61	Yes	No	5	0	0
288	N:N:T306	N:N:T358	3.14	No	No	0	0	0
289	N:N:T306	N:N:T360	3.14	No	Yes	0	0	0
290	N:N:I307	N:N:W321	4.7	No	Yes	0	0	0
291	N:N:I307	N:N:T388	10.64	No	No	0	0	0
292	N:N:C309	N:N:C374	7.28	No	Yes	7	0	0
293	N:N:D356	N:N:R310	4.76	No	No	0	0	0
294	N:N:K313	N:N:S312	3.06	No	No	0	0	0
295	N:N:E379	N:N:K313	8.1	No	No	7	0	0
296	N:N:I319	N:N:V315	4.61	No	No	0	0	0
297	N:N:Q376	N:N:V315	2.87	Yes	No	0	0	0
298	N:N:N378	N:N:V315	5.91	No	No	0	0	0
299	N:N:S316	N:N:Y318	3.82	No	Yes	0	0	0
300	N:N:S353	N:N:T317	3.2	No	No	0	0	0
301	N:N:I377	N:N:Y318	6.04	Yes	Yes	0	0	0
302	N:N:I319	N:N:W321	3.52	No	Yes	0	0	0
303	N:N:F357	N:N:I319	15.07	No	No	0	0	0
304	N:N:H320	N:N:Y322	7.62	Yes	Yes	1	0	0
305	N:N:H320	N:N:L332	5.14	Yes	No	1	0	0
306	N:N:H320	N:N:I377	5.3	Yes	Yes	1	0	0
307	N:N:I334	N:N:W321	5.87	No	Yes	0	0	0
308	N:N:L359	N:N:W321	20.5	No	Yes	0	0	0
309	N:N:C374	N:N:W321	7.84	Yes	Yes	0	0	0
310	N:N:P330	N:N:Y322	4.17	Yes	Yes	1	0	0
311	N:N:L332	N:N:Y322	8.21	No	Yes	1	0	0
312	N:N:Q375	N:N:Y322	10.15	Yes	Yes	1	0	0
313	N:N:Q323	N:N:R325	3.5	Yes	Yes	5	0	0
314	N:N:L333	N:N:Q323	6.65	No	Yes	5	0	0
315	N:N:D368	N:N:Q323	3.92	Yes	Yes	5	0	0
316	N:N:A370	N:N:Q323	3.03	No	Yes	5	0	0
317	N:N:Q323	N:N:Y372	13.53	Yes	Yes	5	0	0
318	N:N:P330	N:N:Q324	7.9	Yes	Yes	1	0	0
319	N:N:N371	N:N:Q324	3.96	No	Yes	1	0	0
320	N:N:Q324	N:N:Y373	3.38	Yes	Yes	1	0	0
321	N:N:Q328	N:N:R325	4.67	No	Yes	0	0	0
322	N:N:D367	N:N:R325	4.76	No	Yes	0	0	0
323	N:N:A370	N:N:R325	4.15	No	Yes	5	0	0
324	N:N:K331	N:N:Q328	2.71	No	No	0	0	0
325	N:N:K331	N:N:Q329	5.42	No	No	0	0	0
326	N:N:E341	N:N:L332	6.63	No	No	0	0	0
327	N:N:L333	N:N:V344	2.98	No	Yes	5	0	0
328	N:N:F348	N:N:L333	4.87	Yes	No	5	0	0
329	N:N:I334	N:N:L340	2.85	No	No	0	0	0
330	N:N:G350	N:N:I334	3.53	No	No	0	0	0
331	N:N:N339	N:N:Y335	16.28	No	No	0	0	0
332	N:N:N339	N:N:S336	2.98	No	No	0	0	0
333	N:N:A337	N:N:F357	2.77	No	No	0	0	0
334	N:N:N339	N:N:S338	2.98	No	No	0	0	0
335	N:N:L340	N:N:V344	2.98	No	Yes	0	0	0
336	N:N:P345	N:N:V344	5.3	No	Yes	5	0	0
337	N:N:F348	N:N:V344	3.93	Yes	Yes	5	0	0
338	N:N:P345	N:N:R347	14.41	No	Yes	5	0	0
339	N:N:F348	N:N:P345	2.89	Yes	No	5	0	0
340	N:N:F348	N:N:R347	8.55	Yes	Yes	5	0	0
341	N:N:E365	N:N:R347	18.61	No	Yes	5	0	0
342	N:N:D368	N:N:R347	14.29	Yes	Yes	5	0	0
343	N:N:F348	N:N:I361	5.02	Yes	Yes	5	0	0
344	N:N:D368	N:N:F348	5.97	Yes	Yes	5	0	0
345	N:N:S349	N:N:T360	4.8	No	Yes	0	0	0
346	N:N:G352	N:N:S351	3.71	No	No	0	0	0
347	N:N:S351	N:N:T358	4.8	No	No	0	0	0
348	N:N:G354	N:N:S353	3.71	No	No	0	0	0
349	N:N:L359	N:N:Y372	3.52	No	Yes	0	0	0
350	N:N:D362	N:N:T360	2.89	No	Yes	15	0	0
351	N:N:I361	N:N:V364	3.07	Yes	No	0	0	0
352	N:N:D368	N:N:I361	2.8	Yes	Yes	5	0	0
353	N:N:I361	N:N:Y372	4.84	Yes	Yes	5	0	0
354	N:N:D368	N:N:E365	5.2	Yes	No	5	0	0
355	N:N:D368	N:N:Y372	3.45	Yes	Yes	5	0	0
356	N:N:I369	N:N:L392	4.28	No	No	0	0	0
357	N:N:N371	N:N:Y373	12.79	No	Yes	1	0	0
358	N:N:K389	N:N:N371	9.79	No	No	0	0	0
359	N:N:T388	N:N:Y372	3.75	No	Yes	0	0	0
360	N:N:L390	N:N:Y372	8.21	No	Yes	0	0	0
361	N:N:G387	N:N:Y373	2.9	No	Yes	0	0	0
362	N:N:I377	N:N:Q375	4.12	Yes	Yes	1	0	0
363	N:N:Q375	N:N:Y382	3.38	Yes	Yes	1	0	0
364	N:N:F384	N:N:Q375	23.42	No	Yes	0	0	0
365	N:N:Q376	N:N:T383	2.83	Yes	No	0	0	0
366	N:N:I377	N:N:Y382	8.46	Yes	Yes	1	0	0
367	N:N:E379	N:N:P381	3.14	No	No	0	0	0
368	N:N:E391	N:N:Y426	3.37	No	No	0	0	0
369	N:N:E391	N:N:Q452	3.82	No	No	0	0	0
370	N:N:L392	N:N:S457	7.51	No	No	0	0	0
371	N:N:A397	N:N:R394	2.77	No	Yes	0	0	0
372	N:N:R394	N:N:Y426	4.12	Yes	No	0	0	0
373	N:N:R394	N:N:T458	5.17	Yes	Yes	0	0	0
374	N:N:D396	N:N:K485	8.3	No	No	0	0	0
375	N:N:A398	N:N:T486	5.03	No	No	0	0	0
376	N:N:M422	N:N:P399	3.35	Yes	No	12	0	0
377	N:N:F425	N:N:P399	10.11	Yes	No	12	0	0
378	N:N:H484	N:N:P399	12.2	Yes	No	12	0	0
379	N:N:N423	N:N:T400	4.39	Yes	No	0	0	0
380	N:N:M422	N:N:V401	7.61	Yes	No	0	0	0
381	N:N:V401	N:N:V482	9.62	No	No	0	0	0
382	N:N:F404	N:N:S402	5.28	Yes	No	4	0	0
383	N:N:L421	N:N:S402	3	Yes	No	4	0	0
384	N:N:C420	N:N:I403	3.27	No	No	0	0	0
385	N:N:I403	N:N:K493	2.91	No	No	0	0	0
386	N:N:F495	N:N:I403	7.54	No	No	0	0	0
387	N:N:F404	N:N:P405	2.89	Yes	No	0	0	0
388	N:N:F404	N:N:L421	6.09	Yes	Yes	4	0	0
389	N:N:F495	N:N:P405	2.89	No	No	0	0	0
390	N:N:P406	N:N:V418	7.07	No	No	0	0	0
391	N:N:P406	N:N:Y472	12.52	No	Yes	0	0	0
392	N:N:E409	N:N:S407	10.06	Yes	No	11	0	0
393	N:N:R410	N:N:S407	3.95	Yes	No	11	0	0
394	N:N:E409	N:N:T408	5.64	Yes	No	0	0	0
395	N:N:R410	N:N:T413	10.35	Yes	No	11	0	0
396	N:N:G415	N:N:R410	4.5	No	Yes	0	0	0
397	N:N:K469	N:N:L411	7.05	No	No	0	0	0
398	N:N:L411	N:N:Y472	4.69	No	Yes	16	0	0
399	N:N:E473	N:N:L411	3.98	No	No	16	0	0
400	N:N:G414	N:N:K469	3.49	No	No	0	0	0
401	N:N:A416	N:N:Y472	4	No	Yes	0	0	0
402	N:N:V418	N:N:W434	3.68	No	Yes	9	0	0
403	N:N:L465	N:N:V418	4.47	No	No	9	0	0
404	N:N:L421	N:N:V419	2.98	Yes	No	0	0	0
405	N:N:T464	N:N:V419	3.17	No	No	0	0	0
406	N:N:C420	N:N:W434	5.22	No	Yes	9	0	0
407	N:N:C420	N:N:C480	7.28	No	No	9	0	0
408	N:N:L421	N:N:S462	4.5	Yes	No	4	0	0
409	N:N:F425	N:N:M422	4.98	Yes	Yes	12	0	0
410	N:N:M422	N:N:M461	4.33	Yes	No	0	0	0
411	N:N:N423	N:N:N424	8.17	Yes	No	4	0	0
412	N:N:N423	N:N:S460	2.98	Yes	Yes	4	0	0
413	N:N:N424	N:N:T458	5.85	No	Yes	4	0	0
414	N:N:F425	N:N:I430	3.77	Yes	No	12	0	0
415	N:N:F425	N:N:Y459	3.09	Yes	No	0	0	0
416	N:N:F425	N:N:H484	7.92	Yes	Yes	12	0	0
417	N:N:D429	N:N:P427	6.44	No	No	0	0	0
418	N:N:H484	N:N:P427	7.63	Yes	No	0	0	0
419	N:N:K485	N:N:P427	11.71	No	No	0	0	0
420	N:N:R428	N:N:V449	11.77	No	No	0	0	0
421	N:N:R428	N:N:Y459	13.38	No	No	0	0	0
422	N:N:I430	N:N:V482	3.07	No	No	0	0	0
423	N:N:H484	N:N:I430	9.28	Yes	No	12	0	0
424	N:N:S431	N:N:V483	4.85	No	No	0	0	0
425	N:N:S463	N:N:V432	6.46	No	No	0	0	0
426	N:N:K433	N:N:K435	8.62	Yes	No	0	0	0
427	N:N:E440	N:N:K433	6.75	No	Yes	17	0	0
428	N:N:K433	N:N:R442	9.9	Yes	No	17	0	0
429	N:N:V445	N:N:W434	7.36	No	Yes	9	0	0
430	N:N:S463	N:N:W434	6.18	No	Yes	0	0	0
431	N:N:L465	N:N:W434	5.69	No	Yes	9	0	0
432	N:N:C480	N:N:W434	5.22	No	Yes	9	0	0
433	N:N:G438	N:N:K435	5.23	No	No	0	0	0
434	N:N:K435	N:N:T479	7.51	No	No	0	0	0
435	N:N:D437	N:N:I436	5.6	No	Yes	8	0	0
436	N:N:I436	N:N:T439	3.04	Yes	No	8	0	0
437	N:N:I436	N:N:R441	6.26	Yes	No	0	0	0
438	N:N:H475	N:N:I436	5.3	Yes	Yes	8	0	0
439	N:N:D437	N:N:T439	7.23	No	No	8	0	0
440	N:N:D437	N:N:H475	12.61	No	Yes	8	0	0
441	N:N:E440	N:N:R442	12.79	No	No	17	0	0
442	N:N:D443	N:N:R441	14.29	No	No	0	0	0
443	N:N:L467	N:N:R441	3.64	No	No	0	0	0
444	N:N:D447	N:N:V445	4.38	No	No	0	0	0
445	N:N:L465	N:N:V445	2.98	No	No	9	0	0
446	N:N:D447	N:N:M461	4.16	No	No	0	0	0
447	N:N:D447	N:N:S463	2.94	No	No	0	0	0
448	N:N:S448	N:N:S462	3.26	No	No	4	0	0
449	N:N:M461	N:N:V449	4.56	No	No	0	0	0
450	N:N:S460	N:N:T450	6.4	Yes	No	4	0	0
451	N:N:Q452	N:N:S457	4.33	No	No	0	0	0
452	N:N:Q452	N:N:Y459	12.4	No	No	0	0	0
453	N:N:D453	N:N:D456	11.98	No	No	4	0	0
454	N:N:D453	N:N:T458	8.67	No	Yes	4	0	0
455	N:N:K455	N:N:S454	3.06	No	No	0	0	0
456	N:N:D456	N:N:K455	8.3	No	No	0	0	0
457	N:N:D456	N:N:T458	13.01	No	Yes	4	0	0
458	N:N:D471	N:N:L467	6.79	No	No	0	0	0
459	N:N:D471	N:N:T468	8.67	No	No	0	0	0
460	N:N:E473	N:N:Y472	3.37	No	Yes	16	0	0
461	N:N:Y472	N:N:Y478	7.94	Yes	No	0	0	0
462	N:N:H475	N:N:Y478	13.07	Yes	No	0	0	0
463	N:N:N476	N:N:N496	9.54	No	No	0	0	0
464	N:N:N476	N:N:R497	8.44	No	No	0	0	0
465	N:N:L477	N:N:T479	2.95	No	No	8	0	0
466	N:N:L477	N:N:S494	3	No	No	8	0	0
467	N:N:S494	N:N:T479	9.59	No	No	8	0	0
468	N:N:E481	N:N:V483	4.28	Yes	No	0	0	0
469	N:N:E481	N:N:P490	9.43	Yes	No	0	0	0
470	N:N:E481	N:N:V492	2.85	Yes	No	0	0	0
471	N:N:V482	N:N:V491	3.21	No	No	0	0	0
472	N:N:H484	N:N:T486	5.48	Yes	No	0	0	0
473	N:N:S487	N:N:T486	3.2	No	No	0	0	0
474	N:N:S487	N:N:S489	3.26	No	No	0	0	0
475	N:N:N498	N:N:R497	3.62	No	No	0	0	0
476	R:R:L37	R:R:V32	2.98	No	No	0	4	6
477	R:R:R40	R:R:V32	9.15	Yes	No	0	6	6
478	R:R:H36	R:R:P33	13.73	No	No	0	8	5
479	R:R:F35	R:R:V127	3.93	No	Yes	0	5	4
480	R:R:H36	R:R:R40	3.39	No	Yes	0	8	6
481	R:R:H36	R:R:L120	7.71	No	No	0	8	1
482	R:R:F38	R:R:V127	9.18	No	Yes	0	5	4
483	R:R:F38	R:R:Y279	4.13	No	Yes	0	5	5
484	R:R:L276	R:R:L41	2.77	Yes	No	0	4	5
485	R:R:L41	R:R:Y279	12.89	No	Yes	0	5	5
486	R:R:D42	R:R:W53	6.7	No	Yes	0	7	2
487	R:R:D42	R:R:R109	13.1	No	Yes	0	7	6
488	R:R:E43	R:R:Y113	5.61	Yes	Yes	1	5	6
489	R:R:E44	R:R:H272	12.31	No	No	0	4	3
490	R:R:E44	R:R:L276	3.98	No	Yes	0	4	4
491	R:R:L45	R:R:W53	7.97	No	Yes	1	4	2
492	R:R:L276	R:R:L45	8.3	Yes	No	1	4	4
493	R:R:H280	R:R:L45	25.71	Yes	No	1	5	4
494	R:R:H46	R:R:W53	22.22	Yes	Yes	1	4	2
495	R:R:H46	R:R:Y113	14.16	Yes	Yes	1	4	6
496	R:R:H46	R:R:Y114	3.27	Yes	Yes	1	4	2
497	R:R:F49	R:R:T48	7.78	No	No	0	3	2
498	R:R:H273	R:R:T48	4.11	No	No	0	3	2
499	R:R:F49	R:R:V277	3.93	No	No	0	3	2
500	R:R:L52	R:R:L56	4.15	No	No	0	3	6
501	R:R:L52	R:R:V277	2.98	No	No	0	3	2
502	R:R:L54	R:R:W53	3.42	No	Yes	0	5	2
503	R:R:M57	R:R:W53	4.65	No	Yes	1	5	2
504	R:R:F110	R:R:W53	6.01	Yes	Yes	1	7	2
505	R:R:W53	R:R:Y113	7.72	Yes	Yes	1	2	6
506	R:R:W53	R:R:Y114	4.82	Yes	Yes	1	2	2
507	R:R:H280	R:R:L56	3.86	Yes	No	0	5	6
508	R:R:L56	R:R:T284	8.84	No	No	0	6	5
509	R:R:F110	R:R:M57	14.93	Yes	No	1	7	5
510	R:R:M57	R:R:Y114	4.79	No	Yes	1	5	2
511	R:R:I63	R:R:V59	3.07	No	No	0	7	5
512	R:R:H60	R:R:L106	5.14	Yes	Yes	1	8	8
513	R:R:H60	R:R:R109	5.64	Yes	Yes	1	8	6
514	R:R:F110	R:R:H60	5.66	Yes	Yes	1	7	8
515	R:R:H60	R:R:T284	8.21	Yes	No	0	8	5
516	R:R:H60	R:R:S287	5.58	Yes	No	1	8	7
517	R:R:I63	R:R:L288	5.71	No	No	0	7	5
518	R:R:F64	R:R:L68	6.09	No	No	0	7	6
519	R:R:F64	R:R:P107	13	No	No	0	7	9
520	R:R:L70	R:R:P294	9.85	No	No	0	6	9
521	R:R:D99	R:R:N71	12.12	Yes	Yes	2	9	9
522	R:R:L100	R:R:N71	2.75	No	Yes	0	5	9
523	R:R:N71	R:R:Y297	3.49	Yes	Yes	2	9	9
524	R:R:L73	R:R:T307	2.95	No	No	0	5	5
525	R:R:A74	R:R:F78	2.77	No	Yes	0	8	6
526	R:R:A74	R:R:F304	4.16	No	Yes	0	8	8
527	R:R:L75	R:R:V96	4.47	No	No	0	7	8
528	R:R:C80	R:R:Y76	4.03	No	No	0	4	3
529	R:R:R81	R:R:Y76	8.23	No	No	0	6	3
530	R:R:T307	R:R:V77	4.76	No	No	0	5	6
531	R:R:F78	R:R:T92	5.19	Yes	Yes	2	6	8
532	R:R:F78	R:R:Y297	4.13	Yes	Yes	2	6	9
533	R:R:F78	R:R:V300	3.93	Yes	No	2	6	6
534	R:R:F78	R:R:T301	5.19	Yes	No	0	6	7
535	R:R:C79	R:R:I93	3.27	No	No	0	2	5
536	R:R:K85	R:R:V89	3.04	No	No	0	5	7
537	R:R:I90	R:R:K85	2.91	No	No	0	7	5
538	R:R:P87	R:R:T86	3.5	No	No	0	6	7
539	R:R:T86	R:R:V89	4.76	No	No	0	7	7
540	R:R:D147	R:R:P87	3.22	No	No	0	8	6
541	R:R:A167	R:R:P87	3.74	No	No	0	8	6
542	R:R:D147	R:R:S88	8.83	No	No	0	8	7
543	R:R:A167	R:R:I90	4.87	No	No	0	8	7
544	R:R:I90	R:R:R168	8.77	No	No	0	7	4
545	R:R:C143	R:R:Y91	8.06	No	Yes	0	6	7
546	R:R:D147	R:R:Y91	3.45	No	Yes	0	8	7
547	R:R:A167	R:R:Y91	4	No	Yes	0	8	7
548	R:R:V170	R:R:Y91	7.57	No	Yes	0	5	7
549	R:R:I144	R:R:T92	4.56	No	Yes	2	8	8
550	R:R:T92	R:R:Y297	3.75	Yes	Yes	2	8	9
551	R:R:T92	R:R:V300	11.11	Yes	No	2	8	6
552	R:R:F140	R:R:N94	13.29	Yes	No	2	7	9
553	R:R:C171	R:R:N94	11.02	No	No	2	7	9
554	R:R:N94	R:R:W175	6.78	No	Yes	2	9	9
555	R:R:D99	R:R:L95	2.71	Yes	Yes	2	9	9
556	R:R:L95	R:R:S137	3	Yes	Yes	2	9	9
557	R:R:L141	R:R:L95	2.77	Yes	Yes	2	8	9
558	R:R:L95	R:R:N293	2.75	Yes	Yes	2	9	9
559	R:R:L95	R:R:Y297	4.69	Yes	Yes	2	9	9
560	R:R:V96	R:R:Y297	6.31	No	Yes	0	8	9
561	R:R:C136	R:R:T98	6.76	No	No	2	6	8
562	R:R:S137	R:R:T98	3.2	Yes	No	2	9	8
563	R:R:T98	R:R:W175	6.06	No	Yes	2	8	9
564	R:R:D99	R:R:S290	2.94	Yes	No	0	9	8
565	R:R:D99	R:R:N293	12.12	Yes	Yes	2	9	9
566	R:R:D99	R:R:Y297	3.45	Yes	Yes	2	9	9
567	R:R:L101	R:R:L132	2.77	No	Yes	0	7	5
568	R:R:N133	R:R:V102	11.82	Yes	No	0	8	6
569	R:R:S290	R:R:V102	3.23	No	No	0	8	6
570	R:R:G129	R:R:S105	3.71	No	No	0	6	6
571	R:R:L106	R:R:S287	9.01	Yes	No	1	8	7
572	R:R:F110	R:R:R109	13.9	Yes	Yes	1	7	6
573	R:R:H126	R:R:R109	11.28	Yes	Yes	1	6	6
574	R:R:R109	R:R:Y130	8.23	Yes	No	1	6	6
575	R:R:Y113	R:R:Y114	9.93	Yes	Yes	1	6	2
576	R:R:R117	R:R:Y113	16.46	Yes	Yes	1	6	6
577	R:R:R117	R:R:Y114	3.09	Yes	Yes	1	6	2
578	R:R:C119	R:R:C122	5.46	No	No	18	3	9
579	R:R:A123	R:R:H126	2.93	No	Yes	0	6	6
580	R:R:F124	R:R:P125	4.33	No	No	0	4	5
581	R:R:F124	R:R:L128	10.96	No	No	0	4	5
582	R:R:H126	R:R:V127	4.15	Yes	Yes	0	6	4
583	R:R:H126	R:R:Y130	5.44	Yes	No	1	6	6
584	R:R:L128	R:R:L132	2.77	No	Yes	0	5	5
585	R:R:L128	R:R:T182	2.95	No	No	0	5	6
586	R:R:V283	R:R:Y130	5.05	No	No	0	5	6
587	R:R:F131	R:R:M134	3.73	Yes	No	0	5	7
588	R:R:F131	R:R:T182	7.78	Yes	No	19	5	6
589	R:R:F131	R:R:V185	6.55	Yes	No	0	5	4
590	R:R:F131	R:R:L186	6.09	Yes	No	19	5	4
591	R:R:L132	R:R:W175	4.56	Yes	Yes	0	5	9
592	R:R:F254	R:R:N133	4.83	No	Yes	2	9	8
593	R:R:N133	R:R:S286	5.96	Yes	No	0	8	8
594	R:R:N133	R:R:N289	10.9	Yes	Yes	2	8	9
595	R:R:L200	R:R:M134	5.65	No	No	0	5	7
596	R:R:E204	R:R:M134	10.83	No	No	0	5	7
597	R:R:H135	R:R:W139	9.52	Yes	Yes	10	8	5
598	R:R:A177	R:R:H135	2.93	No	Yes	0	4	8
599	R:R:A178	R:R:H135	5.85	No	Yes	0	7	8
600	R:R:H135	R:R:V181	5.54	Yes	No	0	8	4
601	R:R:E204	R:R:H135	14.77	No	Yes	10	5	8
602	R:R:C136	R:R:F140	4.19	No	Yes	2	6	7
603	R:R:C136	R:R:W175	5.22	No	Yes	2	6	9
604	R:R:N289	R:R:S137	2.98	Yes	Yes	2	9	9
605	R:R:N293	R:R:S137	2.98	Yes	Yes	2	9	9
606	R:R:I138	R:R:P208	3.39	No	Yes	0	8	9
607	R:R:F250	R:R:I138	10.05	Yes	No	0	9	8
608	R:R:F254	R:R:I138	11.3	No	No	0	9	8
609	R:R:T142	R:R:W139	6.06	No	Yes	10	8	5
610	R:R:E204	R:R:W139	4.36	No	Yes	10	5	5
611	R:R:L207	R:R:W139	3.42	No	Yes	10	6	5
612	R:R:P208	R:R:W139	10.81	Yes	Yes	10	9	5
613	R:R:C171	R:R:F140	4.19	No	Yes	2	7	7
614	R:R:F140	R:R:V174	9.18	Yes	No	0	7	7
615	R:R:F140	R:R:W175	6.01	Yes	Yes	2	7	9
616	R:R:L141	R:R:V246	7.45	Yes	Yes	2	8	8
617	R:R:F250	R:R:L141	6.09	Yes	Yes	2	9	8
618	R:R:L141	R:R:N293	4.12	Yes	Yes	2	8	9
619	R:R:L141	R:R:V296	4.47	Yes	No	0	8	7
620	R:R:P208	R:R:T142	3.5	Yes	No	10	9	8
621	R:R:I144	R:R:V296	3.07	No	No	0	8	7
622	R:R:I144	R:R:V300	3.07	No	No	2	8	6
623	R:R:C145	R:R:I212	4.91	No	Yes	2	9	7
624	R:R:C145	R:R:L243	3.17	No	No	2	9	7
625	R:R:C145	R:R:V246	5.12	No	Yes	2	9	8
626	R:R:L150	R:R:V146	2.98	No	No	0	6	6
627	R:R:F215	R:R:V146	5.24	Yes	No	0	7	6
628	R:R:L242	R:R:R148	3.64	No	No	0	7	9
629	R:R:V153	R:R:Y149	10.09	No	Yes	0	7	8
630	R:R:F215	R:R:Y149	16.5	Yes	Yes	0	7	8
631	R:R:R218	R:R:Y149	10.29	No	Yes	0	4	8
632	R:R:I219	R:R:Y149	4.84	No	Yes	0	7	8
633	R:R:A151	R:R:R162	2.77	No	Yes	0	8	7
634	R:R:I152	R:R:R235	5.01	No	No	0	7	5
635	R:R:I152	R:R:R236	6.26	No	Yes	0	7	6
636	R:R:C161	R:R:E156	6.08	No	No	20	4	5
637	R:R:E156	R:R:R162	11.63	No	Yes	20	5	7
638	R:R:C161	R:R:R162	6.96	No	Yes	20	4	7
639	R:R:L186	R:R:T182	2.95	No	No	19	4	6
640	R:R:G187	R:R:R192	3	No	No	0	2	2
641	R:R:S191	R:R:T189	3.2	No	No	0	4	4
642	R:R:C195	R:R:V197	3.42	No	No	0	9	5
643	R:R:Q261	R:R:V197	5.73	No	No	0	6	5
644	R:R:F205	R:R:T201	3.89	Yes	No	21	9	5
645	R:R:H258	R:R:T201	10.95	No	No	21	8	5
646	R:R:L203	R:R:V202	2.98	No	No	0	3	4
647	R:R:F205	R:R:L206	3.65	Yes	No	0	9	4
648	R:R:F205	R:R:L209	3.65	Yes	Yes	0	9	6
649	R:R:F205	R:R:T255	5.19	Yes	No	0	9	5
650	R:R:F205	R:R:H258	20.36	Yes	No	21	9	8
651	R:R:L207	R:R:P208	3.28	No	Yes	10	6	9
652	R:R:L209	R:R:L247	2.77	Yes	No	0	6	7
653	R:R:F250	R:R:L209	3.65	Yes	Yes	0	9	6
654	R:R:L209	R:R:L251	4.15	Yes	No	0	6	5
655	R:R:I212	R:R:L243	2.85	Yes	No	2	7	7
656	R:R:I212	R:R:V246	3.07	Yes	Yes	2	7	8
657	R:R:I212	R:R:L247	4.28	Yes	No	0	7	7
658	R:R:F250	R:R:I212	3.77	Yes	Yes	2	9	7
659	R:R:L243	R:R:T216	4.42	No	No	0	7	8
660	R:R:L244	R:R:T216	2.95	No	No	0	4	8
661	R:R:I219	R:R:M240	4.37	No	No	0	7	4
662	R:R:C221	R:R:R225	5.57	No	No	0	3	4
663	R:R:A222	R:R:R236	2.77	No	Yes	0	5	6
664	R:R:L223	R:R:R233	8.5	No	No	0	8	3
665	R:R:L223	R:R:V237	4.47	No	No	0	8	5
666	R:R:L229	R:R:Q231	5.32	No	Yes	0	2	4
667	R:R:H230	R:R:Q231	6.18	No	Yes	0	4	4
668	R:R:G232	R:R:Q231	4.93	No	Yes	0	3	4
669	R:R:Q231	R:R:R235	8.18	Yes	No	0	4	5
670	R:R:F299	R:R:R238	8.55	Yes	No	0	7	7
671	R:R:L244	R:R:M240	2.83	No	No	0	4	4
672	R:R:F299	R:R:Q241	5.86	Yes	No	0	7	5
673	R:R:F299	R:R:L242	8.53	Yes	No	0	7	7
674	R:R:I295	R:R:T245	3.04	No	No	0	6	4
675	R:R:F299	R:R:T245	3.89	Yes	No	0	7	4
676	R:R:F250	R:R:V246	3.93	Yes	Yes	2	9	8
677	R:R:L251	R:R:T255	2.95	No	No	0	5	5
678	R:R:C253	R:R:V252	3.42	No	No	0	7	5
679	R:R:C253	R:R:N289	4.72	No	Yes	0	7	9
680	R:R:C253	R:R:M292	3.24	No	No	0	7	7
681	R:R:F254	R:R:N289	10.87	No	Yes	2	9	9
682	R:R:P256	R:R:T255	3.5	No	No	0	9	5
683	R:R:L285	R:R:P256	3.28	No	No	0	7	9
684	R:R:F257	R:R:Q261	8.2	No	No	0	6	6
685	R:R:A282	R:R:F257	2.77	No	No	0	7	6
686	R:R:R260	R:R:S275	3.95	Yes	No	0	4	4
687	R:R:R260	R:R:Y279	13.38	Yes	Yes	0	4	5
688	R:R:L266	R:R:V262	2.98	No	No	0	4	5
689	R:R:D269	R:R:W267	7.82	No	No	0	1	2
690	R:R:M270	R:R:W267	17.45	No	No	0	3	2
691	R:R:M270	R:R:P271	3.35	No	No	0	3	2
692	R:R:M270	R:R:S275	4.6	No	No	0	3	4
693	R:R:P271	R:R:T274	5.25	No	No	0	2	2
694	R:R:H272	R:R:H273	4.78	No	No	0	3	3
695	R:R:H280	R:R:L276	3.86	Yes	Yes	1	5	4
696	R:R:H280	R:R:Y279	7.62	Yes	Yes	0	5	5
697	R:R:V283	R:R:Y279	6.31	No	Yes	0	5	5
698	R:R:N289	R:R:N293	9.54	Yes	Yes	2	9	9
699	R:R:P294	R:R:Y297	8.34	No	Yes	0	9	9
700	R:R:F304	R:R:Y297	5.16	Yes	Yes	0	8	9
701	R:R:Q305	R:R:R309	7.01	No	No	0	8	5
702	R:R:F312	R:R:H315	3.39	No	No	0	4	1
703	R:R:G316	R:R:H315	3.18	No	No	0	1	1
704	N:N:E481	N:N:K433	2.7	Yes	Yes	0	0	0
705	R:R:C171	R:R:Y91	2.69	No	Yes	0	7	7
706	L:L:A119	L:L:Y51	2.67	No	Yes	0	0	0
707	L:L:Q200	N:N:L446	2.66	No	No	0	0	0
708	L:L:F99	L:L:S40	2.64	Yes	No	0	0	0
709	R:R:R162	R:R:S158	2.64	Yes	No	0	7	5
710	R:R:F131	R:R:V127	2.62	Yes	Yes	0	5	4
711	R:R:F215	R:R:V211	2.62	Yes	No	0	7	5
712	R:R:R260	R:R:V264	2.62	Yes	No	0	4	5
713	R:R:R260	R:R:V278	2.62	Yes	No	0	4	4
714	R:R:F304	R:R:V308	2.62	Yes	No	0	8	4
715	L:L:A154	L:L:W215	2.59	No	No	0	0	0
716	R:R:F78	R:R:T82	2.59	Yes	No	0	6	5
717	N:N:H475	N:N:L477	2.57	Yes	No	8	0	0
718	R:R:F78	R:R:I93	2.51	Yes	No	0	6	5
719	L:L:T88	L:L:Y79	2.5	No	Yes	0	0	0
720	R:R:H258	R:R:Q261	2.47	No	No	0	8	6
721	L:L:V192	L:L:W183	2.45	No	Yes	0	0	0
722	R:R:V97	R:R:W175	2.45	No	Yes	0	5	9
723	R:R:F64	R:R:L65	2.44	No	No	0	7	5
724	R:R:F198	R:R:L266	2.44	No	No	0	4	4
725	R:R:L228	R:R:R236	2.43	No	Yes	0	4	6
726	L:L:K84	L:L:Y79	2.39	No	Yes	0	0	0
727	R:R:F198	R:R:R196	2.14	No	No	0	4	3
728	R:R:R159	R:R:R160	2.13	No	No	0	5	4
729	L:L:G73	R:R:G118	2.11	No	No	0	0	7
730	L:L:G120	L:L:G121	2.11	No	No	0	0	0
731	L:L:G238	L:L:G239	2.11	No	No	0	0	0
732	N:N:G414	N:N:G415	2.11	No	No	0	0	0
733	N:N:G302	N:N:P363	2.03	No	No	0	0	0
734	R:R:G51	R:R:P50	2.03	No	No	0	3	5
735	R:R:G227	R:R:P226	2.03	No	No	0	4	5
736	N:N:A386	N:N:G387	1.95	No	No	0	0	0
737	R:R:A66	R:R:G67	1.95	No	No	0	5	8
738	R:R:A178	R:R:G179	1.95	No	No	0	7	3
739	R:R:A306	R:R:G303	1.95	No	No	0	4	6
740	L:L:A147	L:L:P148	1.87	No	No	0	0	0
741	L:L:G45	L:L:S44	1.86	No	No	0	0	0
742	L:L:G241	L:L:S240	1.86	No	No	0	0	0
743	N:N:G354	N:N:S314	1.86	No	No	0	0	0
744	N:N:G350	N:N:S351	1.86	No	No	0	0	0
745	R:R:G157	R:R:S158	1.86	No	No	0	5	5
746	L:L:G73	L:L:T49	1.82	No	No	0	0	0
747	L:L:G61	L:L:T60	1.82	No	No	0	0	0
748	L:L:G186	L:L:T182	1.82	No	No	0	0	0
749	R:R:C79	R:R:C80	1.82	No	No	0	2	4
750	R:R:G217	R:R:T216	1.82	No	No	0	2	8
751	R:R:G303	R:R:T301	1.82	No	No	0	6	7
752	R:R:A66	R:R:C291	1.81	No	No	0	5	6
753	R:R:A116	R:R:C119	1.81	No	No	18	4	3
754	R:R:A116	R:R:C122	1.81	No	No	18	4	9
755	L:L:P155	L:L:V165	1.77	No	No	0	0	0
756	R:R:P125	R:R:T108	1.75	No	No	0	5	6
757	R:R:G217	R:R:M220	1.75	No	No	0	2	4
758	L:L:G173	L:L:K172	1.74	No	No	0	0	0
759	L:L:A31	L:L:S35	1.71	No	No	0	0	0
760	L:L:A143	L:L:S141	1.71	No	No	0	0	0
761	L:L:G202	L:L:L203	1.71	No	No	0	0	0
762	R:R:G103	R:R:L106	1.71	No	Yes	0	5	8
763	R:R:C122	R:R:V112	1.71	No	No	0	9	5
764	R:R:G129	R:R:L132	1.71	No	Yes	0	6	5
765	R:R:C166	R:R:V170	1.71	No	No	0	3	5
766	R:R:G187	R:R:L186	1.71	No	No	0	2	4
767	R:R:G67	R:R:N71	1.7	No	Yes	0	8	9
768	R:R:A123	R:R:V112	1.7	No	No	0	6	5
769	L:L:A225	L:L:T180	1.68	No	No	0	0	0
770	N:N:A470	N:N:T468	1.68	No	No	0	0	0
771	R:R:A84	R:R:T86	1.68	No	No	0	5	7
772	L:L:K32	L:L:P33	1.67	No	No	0	0	0
773	L:L:G63	L:L:Q62	1.64	No	No	0	0	0
774	R:R:C291	R:R:I63	1.64	No	No	0	6	7
775	R:R:L106	R:R:P107	1.64	Yes	No	0	8	9
776	L:L:S26	L:L:S40	1.63	No	No	0	0	0
777	N:N:S417	N:N:S466	1.63	No	No	0	0	0
778	L:L:V198	N:N:S448	1.62	No	No	0	0	0
779	N:N:S312	N:N:V290	1.62	No	No	0	0	0
780	L:L:A225	L:L:K232	1.61	No	No	0	0	0
781	N:N:A296	N:N:K389	1.61	No	No	0	0	0
782	L:L:S213	L:L:T214	1.6	No	No	0	0	0
783	N:N:S316	N:N:T317	1.6	No	No	0	0	0
784	R:R:V277	R:R:V281	1.6	No	No	0	2	5
785	N:N:T292	N:N:V290	1.59	No	No	0	0	0
786	R:R:G61	R:R:H60	1.59	No	Yes	0	5	8
787	R:R:C161	R:R:L150	1.59	No	No	0	4	6
788	R:R:T201	R:R:V262	1.59	No	No	0	5	5
789	R:R:G313	R:R:H317	1.59	No	No	0	4	4
790	R:R:P164	R:R:Q163	1.58	No	No	0	3	6
791	R:R:E31	R:R:P193	1.57	No	No	0	7	4
792	L:L:A187	L:L:N184	1.56	No	Yes	0	0	0
793	R:R:I248	R:R:V252	1.54	No	No	0	4	5
794	R:R:I249	R:R:V296	1.54	No	No	0	6	7
795	R:R:C166	R:R:Q163	1.53	No	No	0	3	6
796	L:L:K93	L:L:V91	1.52	No	No	0	0	0
797	L:L:A143	L:L:Q144	1.52	No	No	0	0	0
798	R:R:I249	R:R:T245	1.52	No	No	0	6	4
799	N:N:A412	N:N:E409	1.51	No	Yes	0	0	0
800	R:R:F312	R:R:G313	1.51	No	No	0	4	4
801	L:L:N223	L:L:S185	1.49	Yes	No	0	0	0
802	R:R:L73	R:R:V308	1.49	No	No	0	5	4
803	N:N:D471	N:N:S474	1.47	No	No	0	0	0
804	L:L:N184	L:L:T221	1.46	Yes	No	0	0	0
805	R:R:G115	R:R:Y114	1.45	No	Yes	0	4	2
806	R:R:P155	R:R:R154	1.44	No	No	0	8	6
807	R:R:P193	R:R:R192	1.44	No	No	0	4	2
808	R:R:P226	R:R:R225	1.44	No	No	0	5	4
809	R:R:Q305	R:R:S302	1.44	No	No	0	8	6
810	R:R:C298	R:R:F304	1.4	No	Yes	0	7	8
811	R:R:A265	R:R:F198	1.39	No	No	0	4	4
812	N:N:A395	N:N:R394	1.38	No	Yes	0	0	0
813	R:R:L104	R:R:L68	1.38	No	No	0	5	6
814	R:R:L311	R:R:L73	1.38	No	No	0	4	5
815	R:R:A239	R:R:R148	1.38	No	No	0	7	9
816	R:R:P268	R:R:W267	1.35	No	No	0	4	2
817	R:R:R225	R:R:S224	1.32	No	No	0	4	4
818	R:R:R154	R:R:V153	1.31	No	No	0	6	7
819	R:R:F215	R:R:V214	1.31	Yes	No	0	7	4
820	N:N:R310	N:N:T355	1.29	No	No	0	0	0
821	L:L:Q20	L:L:Q22	1.28	No	No	0	0	0
822	R:R:I152	R:R:R148	1.25	No	No	0	7	9
823	R:R:I219	R:R:R236	1.25	No	Yes	0	7	6
824	R:R:F38	R:R:L34	1.22	No	No	0	5	4
825	R:R:L223	R:R:R236	1.21	No	Yes	0	8	6
826	R:R:L228	R:R:R233	1.21	No	No	0	4	3
827	R:R:F304	R:R:Q305	1.17	Yes	No	0	8	8
828	N:N:E473	N:N:R497	1.16	No	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Q25	5.39	6	3	0
2	L:L:I39	5.012	5	3	0
3	L:L:Y46	7.3525	4	3	0
4	L:L:F48	6.9	4	0	0
5	L:L:Y51	6.97	4	3	0
6	L:L:Y52	8.29429	7	1	0
7	L:L:W55	10.09	4	3	0
8	L:L:K57	6.17333	6	3	0
9	L:L:Y66	8.742	5	1	0
10	L:L:I67	8.19	4	3	0
11	L:L:F69	5.06571	7	1	0
12	L:L:N71	7.288	5	1	0
13	L:L:Y79	6.65	4	0	0
14	L:L:N80	4.175	4	0	0
15	L:L:L89	7.1975	4	3	0
16	L:L:F99	6.3575	4	0	0
17	L:L:M100	6.91857	7	3	0
18	L:L:L102	4.28	4	3	0
19	L:L:L105	4.6625	4	3	0
20	L:L:D109	6.075	4	0	0
21	L:L:Y113	5.48667	6	3	0
22	L:L:Y114	6.47667	6	1	0
23	L:L:C115	6.0975	4	3	0
24	L:L:R117	9.3	6	3	0
25	L:L:I125	5.375	4	1	0
26	L:L:F129	4.04375	8	1	0
27	L:L:W132	9.066	5	1	0
28	L:L:Y151	8.56	5	11	0
29	L:L:Y174	6.925	6	6	0
30	L:L:F175	5.42	4	0	0
31	L:L:P176	4.588	5	6	0
32	L:L:E177	5.5825	4	6	0
33	L:L:W183	6.23833	6	0	0
34	L:L:N184	5.375	4	0	0
35	L:L:H193	8.31833	6	4	0
36	L:L:F195	6.848	5	4	0
37	L:L:Y204	9.5775	4	6	0
38	L:L:V220	4.685	4	0	0
39	L:L:N223	5.644	5	14	0
40	L:L:H226	6.01571	7	6	0
41	N:N:T289	5.3775	4	7	0
42	N:N:L291	4.506	5	7	0
43	N:N:Q293	5.174	5	7	0
44	N:N:Y318	6.945	4	0	0
45	N:N:H320	6.2125	4	1	0
46	N:N:W321	8.486	5	0	0
47	N:N:Y322	7.80333	6	1	0
48	N:N:Q323	6.126	5	5	0
49	N:N:Q324	5.516	5	1	0
50	N:N:R325	4.27	4	5	0
51	N:N:P330	7.775	4	1	0
52	N:N:V344	3.7975	4	5	0
53	N:N:R347	13.965	4	5	0
54	N:N:F348	5.205	6	5	0
55	N:N:T360	4.325	4	15	0
56	N:N:I361	4.068	5	5	0
57	N:N:D368	5.93833	6	5	0
58	N:N:Y372	6.21667	6	5	0
59	N:N:Y373	6.82	4	1	0
60	N:N:C374	6.8925	4	7	0
61	N:N:Q375	8.916	5	1	0
62	N:N:Q376	4.88	4	7	0
63	N:N:I377	5.98	4	1	0
64	N:N:Y382	8.945	4	1	0
65	N:N:R394	3.36	4	0	0
66	N:N:F404	6.24833	6	4	0
67	N:N:E409	6.2675	4	11	0
68	N:N:R410	9.33	4	11	0
69	N:N:L421	4.1425	4	4	0
70	N:N:M422	5.0675	4	12	0
71	N:N:N423	5.446	5	4	0
72	N:N:F425	5.974	5	12	0
73	N:N:K433	6.9925	4	17	0
74	N:N:W434	5.55833	6	9	0
75	N:N:I436	5.05	4	8	0
76	N:N:T458	8.175	4	4	0
77	N:N:S460	7.17	4	4	0
78	N:N:Y472	6.504	5	16	0
79	N:N:H475	8.3875	4	8	0
80	N:N:E481	4.815	4	0	0
81	N:N:H484	8.502	5	12	0
82	R:R:R40	5.1075	4	0	6
83	R:R:E43	8.248	5	1	5
84	R:R:H46	10.9075	4	1	4
85	R:R:W53	7.93875	8	1	2
86	R:R:H60	5.30333	6	1	8
87	R:R:N71	5.015	4	2	9
88	R:R:F78	3.75857	7	2	6
89	R:R:Y91	5.154	5	0	7
90	R:R:T92	6.1525	4	2	8
91	R:R:L95	3.184	5	2	9
92	R:R:D99	6.668	5	2	9
93	R:R:L106	4.375	4	1	8
94	R:R:R109	10.43	5	1	6
95	R:R:F110	10.125	4	1	7
96	R:R:Y113	10.776	5	1	6
97	R:R:Y114	5.52857	7	1	2
98	R:R:R117	8.21	4	1	6
99	R:R:H126	5.95	4	1	6
100	R:R:V127	4.97	4	0	4
101	R:R:F131	5.354	5	19	5
102	R:R:L132	2.9525	4	0	5
103	R:R:N133	8.3775	4	2	8
104	R:R:H135	7.722	5	10	8
105	R:R:S137	3.04	4	2	9
106	R:R:W139	6.834	5	10	5
107	R:R:F140	7.372	5	2	7
108	R:R:L141	4.98	5	2	8
109	R:R:Y149	10.43	4	0	8
110	R:R:R162	6	4	20	7
111	R:R:W175	5.18	6	2	9
112	R:R:F205	7.348	5	21	9
113	R:R:P208	5.245	4	10	9
114	R:R:L209	3.555	4	0	6
115	R:R:I212	3.776	5	2	7
116	R:R:F215	6.4175	4	0	7
117	R:R:Q231	6.1525	4	0	4
118	R:R:R236	2.784	5	0	6
119	R:R:V246	4.8925	4	2	8
120	R:R:F250	5.498	5	2	9
121	R:R:R260	5.6425	4	0	4
122	R:R:L276	4.7275	4	1	4
123	R:R:Y279	8.866	5	0	5
124	R:R:H280	10.2625	4	1	5
125	R:R:N289	7.802	5	2	9
126	R:R:N293	6.302	5	2	9
127	R:R:Y297	4.915	8	2	9
128	R:R:F299	6.7075	4	0	7
129	R:R:F304	2.902	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I112	L:L:M137	51.563	2.92	No	No	0	0	0
2	L:L:I112	L:L:Y114	52.1439	10.88	No	Yes	0	0	0
3	L:L:L30	L:L:T139	49.8194	2.95	No	No	0	0	0
4	L:L:M137	L:L:T139	50.4007	3.01	No	No	0	0	0
5	L:L:F175	L:L:L30	49.238	6.09	Yes	No	0	0	0
6	L:L:I125	L:L:Y52	10.5385	8.46	Yes	Yes	1	0	0
7	L:L:I126	L:L:Y52	48.6498	9.67	No	Yes	1	0	0
8	L:L:Y52	R:R:R117	25.7293	10.29	Yes	Yes	1	0	6
9	L:L:W132	L:L:Y114	33.4497	6.75	Yes	Yes	1	0	0
10	L:L:W132	N:N:Y322	16.9769	12.54	Yes	Yes	1	0	0
11	L:L:F129	N:N:Y322	38.4253	4.13	Yes	Yes	1	0	0
12	N:N:Q324	N:N:Y373	13.0939	3.38	Yes	Yes	1	0	0
13	L:L:Y114	N:N:P330	16.8061	4.17	Yes	Yes	1	0	0
14	N:N:P330	N:N:Y322	21.2924	4.17	Yes	Yes	1	0	0
15	L:L:A116	L:L:F129	16.8535	2.77	No	Yes	0	0	0
16	L:L:A116	L:L:W132	16.7954	6.48	No	Yes	0	0	0
17	L:L:F122	R:R:Y114	47.3201	11.35	No	Yes	0	0	2
18	R:R:E43	R:R:Y113	11.9235	5.61	Yes	Yes	1	5	6
19	R:R:R117	R:R:Y114	15.5573	3.09	Yes	Yes	1	6	2
20	L:L:L123	N:N:Y318	47.3925	3.52	No	Yes	0	0	0
21	L:L:R124	N:N:Y318	46.8284	14.4	No	Yes	0	0	0
22	L:L:R124	N:N:N378	46.7459	10.85	No	No	0	0	0
23	L:L:I125	R:R:H46	24.0421	3.98	Yes	Yes	1	0	4
24	L:L:Y174	L:L:Y204	32.2951	9.93	Yes	Yes	6	0	0
25	L:L:F175	L:L:Y204	39.8842	3.09	Yes	Yes	0	0	0
26	N:N:G414	N:N:G415	10.8995	2.11	No	No	0	0	0
27	N:N:G414	N:N:K469	11.8071	3.49	No	No	0	0	0
28	N:N:K469	N:N:L411	12.7145	7.05	No	No	0	0	0
29	N:N:L411	N:N:Y472	13.6176	4.69	No	Yes	16	0	0
30	N:N:P406	N:N:Y472	43.5003	12.52	No	Yes	0	0	0
31	N:N:P406	N:N:V418	44.4038	7.07	No	No	0	0	0
32	N:N:V418	N:N:W434	30.2425	3.68	No	Yes	9	0	0
33	N:N:V445	N:N:W434	16.8898	7.36	No	Yes	9	0	0
34	N:N:D447	N:N:V445	32.5472	4.38	No	No	0	0	0
35	N:N:D447	N:N:M461	50.3254	4.16	No	No	0	0	0
36	N:N:M422	N:N:M461	25.4331	4.33	Yes	No	0	0	0
37	N:N:F425	N:N:M422	25.5884	4.98	Yes	Yes	12	0	0
38	N:N:F425	N:N:Y459	27.6179	3.09	Yes	No	0	0	0
39	N:N:Q452	N:N:Y459	53.2201	12.4	No	No	0	0	0
40	N:N:E391	N:N:Q452	54.0273	3.82	No	No	0	0	0
41	N:N:A298	N:N:E391	69.598	3.02	No	No	0	0	0
42	N:N:A298	N:N:K393	69.7206	3.21	No	No	0	0	0
43	N:N:K393	N:N:Q303	69.9653	2.71	No	No	0	0	0
44	N:N:Q303	N:N:V299	34.697	2.87	No	No	5	0	0
45	N:N:L390	N:N:V299	34.7443	5.96	No	No	0	0	0
46	N:N:L390	N:N:Y372	34.8398	8.21	No	Yes	0	0	0
47	N:N:T388	N:N:Y372	21.4308	3.75	No	Yes	0	0	0
48	N:N:Q293	N:N:T388	21.357	8.5	Yes	No	0	0	0
49	N:N:G387	N:N:Q293	16.6931	4.93	No	Yes	0	0	0
50	N:N:G387	N:N:Y373	17.4407	2.9	No	Yes	0	0	0
51	N:N:L465	N:N:V418	15.0646	4.47	No	No	9	0	0
52	N:N:L465	N:N:V445	15.3633	2.98	No	No	9	0	0
53	N:N:S463	N:N:W434	16.8947	6.18	No	Yes	0	0	0
54	N:N:D447	N:N:S463	17.4885	2.94	No	No	0	0	0
55	N:N:M461	N:N:V449	25.1871	4.56	No	No	0	0	0
56	N:N:R428	N:N:V449	25.3279	11.77	No	No	0	0	0
57	N:N:R428	N:N:Y459	25.4714	13.38	No	No	0	0	0
58	N:N:Q303	N:N:V305	35.3904	2.87	No	No	5	0	0
59	N:N:I361	N:N:V305	35.4395	4.61	Yes	No	5	0	0
60	N:N:I361	N:N:Y372	34.9338	4.84	Yes	Yes	5	0	0
61	L:L:L206	L:L:Y174	29.9839	7.03	No	Yes	0	0	0
62	L:L:L206	L:L:T194	22.934	2.95	No	No	0	0	0
63	L:L:T194	L:L:V181	22.3479	4.76	No	No	0	0	0
64	L:L:S208	L:L:V181	21.7618	6.46	No	No	0	0	0
65	L:L:S208	L:L:W183	21.1757	6.18	No	Yes	0	0	0
66	L:L:V220	L:L:W183	17.658	3.68	Yes	Yes	0	0	0
67	N:N:R394	N:N:T458	15.2091	5.17	Yes	Yes	0	0	0
68	N:N:R394	N:N:Y426	15.6971	4.12	Yes	No	0	0	0
69	N:N:E391	N:N:Y426	15.8602	3.37	No	No	0	0	0
70	L:L:N184	L:L:V220	11.7889	8.87	Yes	Yes	0	0	0
71	N:N:N378	N:N:V315	46.721	5.91	No	No	0	0	0
72	N:N:I319	N:N:V315	46.4673	4.61	No	No	0	0	0
73	N:N:L359	N:N:W321	48.9242	20.5	No	Yes	0	0	0
74	N:N:L359	N:N:Y372	48.9235	3.52	No	Yes	0	0	0
75	N:N:Y472	N:N:Y478	23.595	7.94	Yes	No	0	0	0
76	N:N:H475	N:N:Y478	22.6889	13.07	Yes	No	0	0	0
77	N:N:H475	N:N:L477	11.8071	2.57	Yes	No	8	0	0
78	R:R:W53	R:R:Y113	22.2718	7.72	Yes	Yes	1	2	6
79	R:R:D42	R:R:W53	40.9538	6.7	No	Yes	0	7	2
80	R:R:D42	R:R:R109	40.8058	13.1	No	Yes	0	7	6
81	R:R:H126	R:R:R109	100	11.28	Yes	Yes	1	6	6
82	R:R:H126	R:R:V127	97.6928	4.15	Yes	Yes	0	6	4
83	R:R:F110	R:R:W53	42.7445	6.01	Yes	Yes	1	7	2
84	R:R:F110	R:R:R109	60.233	13.9	Yes	Yes	1	7	6
85	R:R:M57	R:R:Y114	20.4347	4.79	No	Yes	1	5	2
86	R:R:F131	R:R:V127	97.3516	2.62	Yes	Yes	0	5	4
87	R:R:F131	R:R:T182	51.1573	7.78	Yes	No	19	5	6
88	R:R:L128	R:R:T182	50.8037	2.95	No	No	0	5	6
89	R:R:L128	R:R:L132	49.2708	2.77	No	Yes	0	5	5
90	R:R:L132	R:R:W175	47.7365	4.56	Yes	Yes	0	5	9
91	R:R:T98	R:R:W175	28.4034	6.06	No	Yes	2	8	9
92	R:R:S137	R:R:T98	28.5334	3.2	Yes	No	2	9	8
93	R:R:L95	R:R:S137	20.8471	3	Yes	Yes	2	9	9
94	R:R:L95	R:R:Y297	15.9364	4.69	Yes	Yes	2	9	9
95	R:R:F131	R:R:M134	43.4804	3.73	Yes	No	0	5	7
96	R:R:E204	R:R:M134	42.681	10.83	No	No	0	5	7
97	R:R:E204	R:R:W139	40.2335	4.36	No	Yes	10	5	5
98	R:R:P208	R:R:W139	39.0711	10.81	Yes	Yes	10	9	5
99	R:R:I138	R:R:P208	38.7046	3.39	No	Yes	0	8	9
100	R:R:F250	R:R:I138	34.2453	10.05	Yes	No	0	9	8
101	R:R:C171	R:R:Y91	18.4166	2.69	No	Yes	0	7	7
102	R:R:F140	R:R:W175	10.271	6.01	Yes	Yes	2	7	9
103	R:R:F250	R:R:I212	16.3563	3.77	Yes	Yes	2	9	7
104	R:R:I212	R:R:L243	15.5511	2.85	Yes	No	2	7	7
105	R:R:L243	R:R:T216	15.5018	4.42	No	No	0	7	8
106	R:R:L244	R:R:T216	14.1542	2.95	No	No	0	4	8
107	R:R:L244	R:R:M240	13.7054	2.83	No	No	0	4	4
108	R:R:I219	R:R:M240	13.2569	4.37	No	No	0	7	4
109	L:L:F129	L:L:I126	60.4146	3.77	Yes	No	1	0	0
110	L:L:F122	L:L:L123	47.3505	4.87	No	No	0	0	0
111	L:L:F69	L:L:I126	11.8041	5.02	Yes	No	1	0	0
112	N:N:I319	N:N:W321	46.4615	3.52	No	Yes	0	0	0
113	L:L:F69	L:L:I125	14.4112	3.77	Yes	Yes	1	0	0
114	R:R:H46	R:R:W53	23.999	22.22	Yes	Yes	1	4	2
115	L:L:Y52	R:R:E43	10.5497	6.73	Yes	Yes	1	0	5
116	R:R:R117	R:R:Y113	10.4048	16.46	Yes	Yes	1	6	6
117	R:R:W53	R:R:Y114	42.0762	4.82	Yes	Yes	1	2	2
118	R:R:F110	R:R:M57	20.3572	14.93	Yes	No	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y52	R:R:E43	6.73	1	Yes	Yes	0	5	0	1
L:L:Y52	R:R:R117	10.29	1	Yes	Yes	0	6	0	1
L:L:N71	R:R:E43	9.2	1	Yes	Yes	0	5	0	1
L:L:N71	R:R:G118	5.09	1	Yes	No	0	7	0	1
L:L:S74	R:R:E43	8.62	1	No	Yes	0	5	0	1
L:L:G75	R:R:R40	4.5	0	No	Yes	0	6	0	1
L:L:H76	R:R:R40	3.39	0	No	Yes	0	6	0	1
L:L:H76	R:R:E43	11.08	0	No	Yes	0	5	0	1
L:L:G120	R:R:R117	3	1	No	Yes	0	6	0	1
L:L:F122	R:R:Y114	11.35	0	No	Yes	0	2	0	1
L:L:R124	R:R:P50	11.53	0	No	No	0	5	0	1
L:L:I125	R:R:H46	3.98	1	Yes	Yes	0	4	0	1
L:L:I125	R:R:G47	5.29	1	Yes	No	0	2	0	1
R:R:R40	R:R:V32	9.15	0	Yes	No	6	6	1	2
R:R:H36	R:R:R40	3.39	0	No	Yes	8	6	2	1
R:R:E43	R:R:Y113	5.61	1	Yes	Yes	5	6	1	2
R:R:H46	R:R:W53	22.22	1	Yes	Yes	4	2	1	2
R:R:H46	R:R:Y113	14.16	1	Yes	Yes	4	6	1	2
R:R:H46	R:R:Y114	3.27	1	Yes	Yes	4	2	1	1
R:R:M57	R:R:W53	4.65	1	No	Yes	5	2	2	2
R:R:W53	R:R:Y113	7.72	1	Yes	Yes	2	6	2	2
R:R:W53	R:R:Y114	4.82	1	Yes	Yes	2	2	2	1
R:R:M57	R:R:Y114	4.79	1	No	Yes	5	2	2	1
R:R:Y113	R:R:Y114	9.93	1	Yes	Yes	6	2	2	1
R:R:R117	R:R:Y113	16.46	1	Yes	Yes	6	6	1	2
R:R:R117	R:R:Y114	3.09	1	Yes	Yes	6	2	1	1
L:L:G73	R:R:G118	2.11	0	No	No	0	7	0	1
R:R:G51	R:R:P50	2.03	0	No	No	3	5	2	1
R:R:G115	R:R:Y114	1.45	0	No	Yes	4	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
62.50	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/β1/γ2
35.71	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
33.33	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
33.33	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
29.41	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
29.41	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
29.41	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
27.78	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
26.32	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
26.32	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
25.00	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
25.00	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
22.73	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
22.22	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
22.22	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
20.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
20.00	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
20.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
20.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
20.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
20.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
20.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042
20.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
20.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
20.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
20.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
20.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626
20.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
20.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
20.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
20.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
20.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
20.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
20.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
20.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
20.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
20.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
20.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
20.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
20.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
20.00	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
20.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
20.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
20.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
20.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
20.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
20.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
20.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
20.00	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
20.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
20.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
20.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
20.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
20.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
20.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
20.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
20.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
20.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
20.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
20.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
20.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
20.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
20.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
20.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
20.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
20.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
20.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
20.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
20.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
20.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
20.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
20.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
20.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
20.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
20.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
20.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
20.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
20.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
20.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
20.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
20.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
20.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
20.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
20.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
20.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
20.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
20.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
20.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
20.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
20.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
20.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
20.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
20.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
20.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
20.00	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
20.00	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
20.00	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
20.00	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
20.00	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
20.00	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
20.00	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
20.00	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
20.00	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
20.00	Single	8WG9	(2S)-2-amino-4-phosphonobutanoic acid	8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
20.00	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
20.00	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
20.00	Single	8WGC	LY379268	8WGC-mGlu4; mGlu2-LY379268
20.00	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
20.00	Single	8WGD	WAG; WA6	8WGD-mGlu4; mGlu2-WAG; WA6
20.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00	Single	8WVX	Norrin	8WVX-LGR4-Norrin
20.00	Single	8WVY	Norrin	8WVY-LGR4-Norrin
20.00	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
20.00	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
20.00	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
20.00	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
20.00	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
20.00	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
20.00	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
20.00	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
20.00	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
20.00	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
20.00	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
20.00	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
20.00	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
20.00	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
20.00	Single	9KHH	Norrin	9KHH-LGR4-Norrin
20.00	Single	9S37	NB21	9S37-LGR4-NB21
20.00	Single	9UTB	Sucralose	9UTB-TAS1R2; TAS1R3-Sucralose
20.00	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
19.23	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
19.05	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
19.05	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
18.52	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
18.52	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
18.18	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
18.18	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
18.18	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
17.86	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
17.86	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
17.86	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
17.86	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
17.65	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
17.65	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
17.39	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.39	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
17.39	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.24	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
16.67	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
16.67	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
16.67	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
16.67	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.67	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
16.67	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
16.67	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
16.67	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
16.67	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.67	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
16.67	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
16.67	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
16.67	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.67	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.67	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
16.67	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
16.13	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
16.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
16.00	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
16.00	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.00	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
16.00	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
16.00	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
16.00	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.79	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
15.38	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
15.38	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.38	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
15.38	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
15.38	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
15.00	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
15.00	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
15.00	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
14.29	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
14.29	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.29	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.29	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
14.29	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
14.29	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
14.29	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
14.29	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
14.29	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
14.29	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
14.29	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
14.29	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
14.29	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
13.64	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
13.64	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
13.64	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
13.64	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
13.64	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
13.64	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
13.64	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
13.64	Single	9BLC	Cagrilintide backbone (non-acylated)	9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.64	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
13.64	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
13.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
13.33	Single	8ZYT	Neurotensin peptide 8-13	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
13.33	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
13.33	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.33	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
13.33	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
13.33	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
13.04	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.04	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.04	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
13.04	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
13.04	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
13.04	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
13.04	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
13.04	Consensus	pac_on	Orthosteric Ligand	pac1_on
13.04	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
13.04	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
12.90	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
12.50	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
12.50	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
12.50	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
12.50	Single	6FJ3	PTH	6FJ3-PTH1-PTH
12.50	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
12.50	Single	6OS1	TRV026	6OS1-AT₁-TRV026
12.50	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.50	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
12.50	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
12.50	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
12.50	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
12.50	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
12.50	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
12.50	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
12.50	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
12.50	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
12.50	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
12.50	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
12.50	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
12.50	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
12.50	Single	9BLB	Cagrilintide backbone (non-acylated)	9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
12.50	Single	9BLW	Cagrilintide backbone (non-acylated)	9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
12.50	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
12.50	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
12.50	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
12.50	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.50	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
12.50	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
12.50	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
12.50	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
12.50	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
12.50	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
12.50	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
12.50	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
12.00	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.00	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
12.00	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
12.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
12.00	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
12.00	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
12.00	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
12.00	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
12.00	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
12.00	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
11.76	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
11.76	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
11.76	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
11.76	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
11.76	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
11.76	Single	6OS2	TRV026	6OS2-AT₁-TRV026
11.76	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
11.76	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
11.76	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
11.76	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
11.76	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
11.76	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
11.76	Single	8XQJ	JN241	8XQJ-Apelin-JN241
11.76	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
11.76	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
11.76	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
11.76	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
11.76	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
11.76	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
11.76	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
11.76	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
11.54	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
11.54	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
11.54	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
11.54	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
11.54	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
11.54	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.54	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
11.54	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
11.54	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
11.54	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
11.54	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
11.54	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
11.54	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
11.11	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
11.11	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
11.11	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
11.11	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
11.11	Single	6VCB	LSN3160440	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
11.11	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
11.11	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
11.11	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
11.11	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
11.11	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
11.11	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
11.11	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
11.11	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
11.11	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-SBI-553
11.11	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
11.11	Consensus	crf1_on	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
11.11	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
11.11	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
11.11	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
10.71	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
10.71	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.71	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
10.71	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
10.53	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
10.53	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
10.53	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
10.53	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
10.53	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
10.53	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
10.53	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
10.53	Single	8XQJ	JN241	8XQJ-Apelin-JN241
10.34	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
10.34	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34	Consensus	crf1_on_gp	Orthosteric Ligand	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
10.34	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
10.00	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
10.00	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
10.00	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
10.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
10.00	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
10.00	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
10.00	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
10.00	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
10.00	Single	9IVM	LSN3318839	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.00	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
10.00	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
10.00	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
10.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
10.00	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
9.68	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.52	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
9.52	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
9.52	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
9.52	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
9.52	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
9.52	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
9.52	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
9.09	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
9.09	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
9.09	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
9.09	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
9.09	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
9.09	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
9.09	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
9.09	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
9.09	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
9.09	Single	9JHJ	C18:0 Ceramide	9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
9.09	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
9.09	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
9.09	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
9.09	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
9.09	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
9.09	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
8.82	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
8.70	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
8.70	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
8.70	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
8.70	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
8.70	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
8.70	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
8.70	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
8.70	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
8.70	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
8.70	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
8.70	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
8.70	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
8.57	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
8.33	Single	6LI0	C17	6LI0-GPR52-C17
8.33	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
8.33	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
8.33	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
8.33	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
8.33	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
8.33	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
8.33	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
8.33	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
8.33	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
8.33	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
8.33	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
8.33	Single	9B9Y	7DY	9B9Y-CB₁-7DY
8.33	Single	9E7R	GB88	9E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
8.00	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
8.00	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
8.00	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
8.00	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
8.00	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
8.00	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
8.00	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
8.00	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
8.00	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
8.00	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
8.00	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
8.00	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
8.00	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
7.69	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
7.69	Single	5U09	Taranabant	5U09-CB₁-Taranabant
7.69	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
7.69	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
7.69	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
7.69	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
7.69	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
7.69	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
7.69	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
7.69	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
7.69	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
7.69	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
7.69	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
7.69	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
7.69	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
7.69	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
7.69	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
7.69	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
7.69	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
7.69	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
7.69	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
7.69	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
7.69	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
7.69	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
7.69	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
7.69	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.69	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
7.69	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
7.69	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.69	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
7.69	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
7.69	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
7.69	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
7.41	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
7.41	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
7.41	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
7.41	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
7.41	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
7.41	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
7.41	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
7.41	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
7.41	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
7.41	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
7.41	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
7.41	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.14	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
7.14	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
7.14	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
7.14	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
7.14	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
7.14	Single	7UTZ	DPPC	7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
7.14	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
7.14	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.14	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
7.14	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
7.14	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
7.14	Single	9JFU	NE52-QQ57	9JFU-GPR4-NE52-QQ57
7.14	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
7.14	Single	9M2F	Neuropeptide FF	9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
7.14	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
7.14	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.14	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
7.14	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
7.14	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.90	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
6.90	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.90	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
6.90	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
6.67	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
6.67	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
6.67	Single	6D27	CAY10471	6D27-DP₂-CAY10471
6.67	Single	6IIV	Daltroban	6IIV-TXA2-Daltroban
6.67	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
6.67	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
6.67	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
6.67	Single	6XBM	5LWE	6XBM-SMO-5LWE-Gi1/β1/γ2
6.67	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
6.67	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
6.67	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
6.67	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
6.67	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
6.67	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
6.67	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
6.67	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
6.67	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
6.67	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
6.67	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
6.67	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
6.67	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
6.67	Single	8ZYY	Neurotensin peptide 8-13	8ZYY-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
6.67	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
6.67	Single	9IZC	MK1903	9IZC-HCA₂-MK1903-Gi1/β1/γ2
6.67	Single	9KFJ	PubChem 138319674	9KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
6.67	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
6.67	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
6.67	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
6.67	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
6.67	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
6.67	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
6.67	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
6.67	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
6.67	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
6.67	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.25	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
6.25	Single	5C1M	BU72	5C1M-μ-BU72
6.25	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
6.25	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
6.25	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
6.25	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
6.25	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
6.25	Single	7C4S	S1P	7C4S-S1P₃-S1P
6.25	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
6.25	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
6.25	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
6.25	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
6.25	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
6.25	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
6.25	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
6.25	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
6.25	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.25	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
6.25	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
6.25	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
6.25	Single	9CIB	FCH-2296413	9CIB-HCA₂-FCH-2296413
6.25	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
6.25	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
6.25	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go/β1/γ2
6.25	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
6.25	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
6.25	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
6.25	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
6.25	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
5.88	Single	5V56	TC114	5V56-SMO-TC114
5.88	Single	5V57	TC114	5V57-SMO-TC114
5.88	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
5.88	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.88	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
5.88	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
5.88	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
5.88	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
5.88	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
5.88	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.88	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
5.88	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
5.88	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
5.88	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
5.88	Single	8E0G	BU72	8E0G-μ-BU72
5.88	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
5.88	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
5.88	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
5.88	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
5.88	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
5.88	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
5.88	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
5.88	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
5.88	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
5.88	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
5.88	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
5.88	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
5.88	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
5.88	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
5.88	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
5.88	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
5.88	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
5.88	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
5.88	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
5.88	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.88	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
5.56	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
5.56	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
5.56	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
5.56	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
5.56	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
5.56	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
5.56	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
5.56	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
5.56	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
5.56	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
5.56	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
5.56	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
5.56	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
5.56	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
5.56	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
5.56	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.56	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
5.56	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
5.56	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
5.56	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
5.56	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
5.56	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
5.56	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
5.56	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.56	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
5.56	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
5.56	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
5.56	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.56	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
5.56	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
5.56	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
5.56	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
5.56	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.56	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
5.56	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.56	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.56	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
5.26	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
5.26	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
5.26	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
5.26	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
5.26	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
5.26	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
5.26	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
5.26	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
5.26	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
5.26	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
5.26	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
5.26	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
5.26	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
5.26	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
5.26	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
5.26	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
5.26	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.26	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
5.26	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Single	9M1H	Prostaglandin E2	9M1H-EP₁-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
5.26	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.26	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
5.26	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
5.26	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
5.26	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
5.26	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
5.26	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
5.00	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
5.00	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
5.00	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
5.00	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
5.00	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
5.00	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
5.00	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
5.00	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
5.00	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
5.00	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
5.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
5.00	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
5.00	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
5.00	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
5.00	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
5.00	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
5.00	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
5.00	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
5.00	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
4.76	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
4.76	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
4.76	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
4.76	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
4.76	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
4.76	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
4.76	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.76	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
4.76	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.76	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
4.76	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.76	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
4.76	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
4.76	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
4.76	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
4.76	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.76	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
4.76	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
4.76	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
4.76	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
4.76	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
4.76	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.76	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
4.76	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
4.76	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
4.76	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
4.76	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
4.76	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
4.55	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
4.55	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
4.55	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
4.55	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
4.55	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
4.55	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
4.55	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.55	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
4.55	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
4.55	Single	9E82	SDF-1-beta	9E82-ACKR3-SDF-1-β-Arrestin2
4.55	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
4.55	Single	9KFI	Relaxin-3	9KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
4.55	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
4.55	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
4.55	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.55	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.55	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.55	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
4.55	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
4.55	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
4.55	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
4.55	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.55	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
4.35	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
4.35	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.35	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
4.35	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
4.35	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
4.35	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
4.35	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
4.35	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
4.35	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.35	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-ZNRF3
4.35	Single	9B5Y	Long-Acting PTH	9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
4.35	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
4.35	Single	9M1O	Morphine-Modulating Neuropeptide B	9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
4.35	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
4.35	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
4.35	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
4.35	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.35	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.35	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.35	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
4.17	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
4.17	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
4.17	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.17	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
4.17	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.17	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
4.17	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
4.17	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
4.17	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
4.17	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.17	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.17	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3
4.17	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.17	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.17	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
4.17	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.17	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.17	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.17	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
4.17	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
4.17	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.17	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
4.17	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
4.17	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
4.00	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.00	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
4.00	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.00	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
4.00	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
4.00	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.00	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
4.00	Single	9JFY	hNPSF	9JFY-NPFF2-hNPSF-Gi1/β1/γ2
4.00	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.00	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
4.00	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
4.00	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
4.00	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
4.00	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.00	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
4.00	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.85	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
3.85	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
3.85	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
3.85	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.85	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
3.85	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	9KFK	Relaxin-3	9KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
3.85	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
3.85	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.85	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
3.85	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
3.70	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
3.70	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
3.70	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.70	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
3.70	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3
3.70	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
3.70	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
3.70	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.70	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.57	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
3.57	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
3.57	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
3.57	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.57	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
3.45	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
3.45	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.45	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.45	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
3.45	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
3.45	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.45	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.45	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.45	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.45	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
3.45	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
3.33	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.33	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.33	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
3.33	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.12	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
2.94	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.94	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.50	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB	8HS2
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR20
Species	Homo Sapiens
Ligand	Fab046
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.08
Date	2023-03-08
D.O.I.	doi.org/10.1038/s41421-023-00520-8

Net Summary
I_min	2.71
Number of Linked Nodes	673
Number of Links	828
Number of Hubs	129
Number of Links mediated by Hubs	477
Number of Communities	21
Number of Nodes involved in Communities	192
Number of Links involved in Communities	287

Path Summary
Number Of Nodes in MetaPath	119
Number Of Links MetaPath	118
Number of Shortest Paths	2572356
Length Of Smallest Path	3
Average Path Length	33.8861
Length of Longest Path	63
Minimum Path Strength	1.23
Average Path Strength	6.17179
Maximum Path Strength	19.015
Minimum Path Correlation	0.7
Average Path Correlation	0.988748
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	47.5683
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.9034
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99678
Sequence	>8HS2_Chain_R E V P L F H L F A R L D E E L H G T F P G L W L A L M A V H G A I F L A G L V L N G L A L Y V F C C R T R A K T P S V I Y T I N L V V T D L L V G L S L P T R F A V Y Y G A R G C L R C A F P H V L G Y F L N M H C S I W F L T C I C V D R Y L A I V R P E G S R R C R Q P A C A R A V C A F V W L A A G A V T L S V L G V T G S R P C C R V F A L T V L E F L L P L L V I S V F T G R I M C A L S R P G L L H Q G R Q R R V R A M Q L L L T V L I I F L V C F T P F H A R Q V A V A L W P D M P H H T S L V V Y H V A V T L S S L N S C M N P I V Y C F V T S G F Q A T V R G L F G Q H G H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HS2	A	Orphan	Orphan	GPR20	Homo sapiens	Fab046	-	-	3.08	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HS3	A	Orphan	Orphan	GPR20	Homo sapiens	-	-	Gi1/β1/γ2	3.14	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HS3 (No Gprot)	A	Orphan	Orphan	GPR20	Homo sapiens	-	-		3.14	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HSC	A	Orphan	Orphan	GPR20	Homo sapiens	Fab046	-	Gi1/β1/γ2	3.22	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HSC (No Gprot)	A	Orphan	Orphan	GPR20	Homo sapiens	Fab046	-		3.22	2023-03-08	doi.org/10.1038/s41421-023-00520-8

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