psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:Q20	E:E:S19	10.11	No	No	0	0	0
2	E:E:V21	E:E:Y46	5.05	No	Yes	3	0	0
3	E:E:R117	E:E:V21	3.92	Yes	No	3	0	0
4	E:E:V21	E:E:Y131	11.36	No	No	3	0	0
5	E:E:C41	E:E:L23	4.76	No	No	3	0	0
6	E:E:C115	E:E:L23	3.17	Yes	No	3	0	0
7	E:E:L23	E:E:R117	3.64	No	Yes	3	0	0
8	E:E:Q134	E:E:Q24	10.24	No	No	0	0	0
9	E:E:C41	E:E:Q25	6.1	No	Yes	3	0	0
10	E:E:C115	E:E:Q25	6.1	Yes	Yes	3	0	0
11	E:E:G133	E:E:Q25	3.29	No	Yes	0	0	0
12	E:E:Q134	E:E:Q25	6.4	No	Yes	0	0	0
13	E:E:G135	E:E:Q25	3.29	No	Yes	0	0	0
14	E:E:Q25	E:E:V136	7.16	Yes	No	0	0	0
15	E:E:G27	E:E:S26	3.71	No	No	0	0	0
16	E:E:S26	E:E:V136	3.23	No	No	0	0	0
17	E:E:A28	E:E:M137	3.22	No	No	0	0	0
18	E:E:E29	E:E:V37	2.85	No	No	0	0	0
19	E:E:L30	E:E:T139	2.95	No	No	0	0	0
20	E:E:F175	E:E:L30	6.09	Yes	No	0	0	0
21	E:E:K32	E:E:S35	3.06	No	No	0	0	0
22	E:E:P33	E:E:V140	3.53	No	No	0	0	0
23	E:E:P33	E:E:S142	3.56	No	No	0	0	0
24	E:E:Q101	E:E:S36	5.78	No	No	0	0	0
25	E:E:L102	E:E:V37	4.47	Yes	No	3	0	0
26	E:E:L105	E:E:V37	2.98	Yes	No	3	0	0
27	E:E:F99	E:E:K38	12.41	Yes	No	0	0	0
28	E:E:K38	E:E:Q101	2.71	No	No	0	0	0
29	E:E:I39	E:E:W55	8.22	Yes	Yes	3	0	0
30	E:E:I39	E:E:M100	7.29	Yes	Yes	3	0	0
31	E:E:I39	E:E:L102	2.85	Yes	Yes	3	0	0
32	E:E:I39	E:E:Y113	3.63	Yes	Yes	3	0	0
33	E:E:I39	E:E:V136	3.07	Yes	No	0	0	0
34	E:E:C115	E:E:C41	7.28	Yes	No	3	0	0
35	E:E:K42	E:E:T97	4.5	No	No	0	0	0
36	E:E:A43	E:E:Y46	4	No	Yes	0	0	0
37	E:E:A43	E:E:F48	2.77	No	Yes	0	0	0
38	E:E:Y46	E:E:Y51	5.96	Yes	Yes	3	0	0
39	E:E:R117	E:E:Y46	14.4	Yes	Yes	3	0	0
40	E:E:S50	E:E:T47	6.4	No	No	0	0	0
41	E:E:F48	E:E:I53	3.77	Yes	No	0	0	0
42	E:E:F48	E:E:P72	14.45	Yes	No	0	0	0
43	E:E:F48	E:E:S96	6.61	Yes	No	0	0	0
44	E:E:S50	E:E:Y51	3.82	No	Yes	0	0	0
45	E:E:R117	E:E:Y51	15.43	Yes	Yes	3	0	0
46	E:E:F69	E:E:Y52	7.22	Yes	Yes	1	0	0
47	E:E:N71	E:E:Y52	12.79	Yes	Yes	1	0	0
48	E:E:G120	E:E:Y52	2.9	No	Yes	1	0	0
49	E:E:I125	E:E:Y52	8.46	Yes	Yes	1	0	0
50	E:E:I126	E:E:Y52	9.67	No	Yes	1	0	0
51	E:E:Y52	R:R:E43	6.73	Yes	Yes	1	0	5
52	E:E:Y52	R:R:R117	10.29	Yes	Yes	1	0	6
53	E:E:A98	E:E:I53	4.87	No	No	0	0	0
54	E:E:I56	E:E:S54	3.1	No	No	0	0	0
55	E:E:F129	E:E:S54	5.28	Yes	No	0	0	0
56	E:E:L89	E:E:W55	5.69	Yes	Yes	3	0	0
57	E:E:M100	E:E:W55	18.61	Yes	Yes	3	0	0
58	E:E:C115	E:E:W55	7.84	Yes	Yes	3	0	0
59	E:E:I56	E:E:W132	4.7	No	Yes	0	0	0
60	E:E:I56	e:e:F384	6.28	No	No	0	0	0
61	E:E:K57	E:E:T59	3	Yes	No	3	0	0
62	E:E:I67	E:E:K57	5.82	Yes	Yes	3	0	0
63	E:E:F83	E:E:K57	8.69	No	Yes	3	0	0
64	E:E:D108	E:E:K57	2.77	No	Yes	0	0	0
65	E:E:A111	E:E:K57	4.82	No	Yes	3	0	0
66	E:E:K57	E:E:Y113	11.94	Yes	Yes	3	0	0
67	E:E:L64	E:E:Q58	11.98	No	No	0	0	0
68	E:E:Q58	E:E:Y114	7.89	No	Yes	1	0	0
69	E:E:Q58	e:e:Q324	8.96	No	Yes	1	0	0
70	E:E:Q62	E:E:T59	8.5	No	No	0	0	0
71	E:E:A111	E:E:T59	3.36	No	No	3	0	0
72	E:E:G61	E:E:Q62	3.29	No	No	0	0	0
73	E:E:L64	e:e:Y373	8.21	No	Yes	0	0	0
74	E:E:L64	e:e:F384	14.61	No	No	0	0	0
75	E:E:K65	E:E:K82	2.87	No	No	0	0	0
76	E:E:G68	E:E:Y66	7.24	No	Yes	0	0	0
77	E:E:F69	E:E:Y66	5.16	Yes	Yes	1	0	0
78	E:E:N78	E:E:Y66	4.65	No	Yes	1	0	0
79	E:E:N80	E:E:Y66	5.81	Yes	Yes	0	0	0
80	E:E:Y66	e:e:Y382	20.85	Yes	Yes	1	0	0
81	E:E:G68	E:E:I67	3.53	No	Yes	0	0	0
82	E:E:F83	E:E:I67	17.58	No	Yes	3	0	0
83	E:E:I67	E:E:M100	5.83	Yes	Yes	3	0	0
84	E:E:F69	E:E:H76	3.39	Yes	No	0	0	0
85	E:E:F69	E:E:N78	7.25	Yes	No	1	0	0
86	E:E:F69	E:E:I125	3.77	Yes	Yes	1	0	0
87	E:E:F69	E:E:I126	5.02	Yes	No	1	0	0
88	E:E:F69	e:e:L380	3.65	Yes	No	1	0	0
89	E:E:I70	E:E:T77	7.6	No	No	0	0	0
90	E:E:I70	E:E:L89	7.14	No	Yes	0	0	0
91	E:E:I70	E:E:V91	6.14	No	No	0	0	0
92	E:E:N71	E:E:P72	4.89	Yes	No	0	0	0
93	E:E:N71	E:E:S74	4.47	Yes	No	1	0	0
94	E:E:N71	R:R:E43	9.2	Yes	Yes	1	0	5
95	E:E:N71	R:R:G118	5.09	Yes	No	0	0	7
96	E:E:P72	E:E:V91	7.07	No	No	0	0	0
97	E:E:S74	R:R:E43	8.62	No	Yes	1	0	5
98	E:E:G75	R:R:R40	4.5	No	Yes	0	0	6
99	E:E:H76	R:R:R40	3.39	No	Yes	0	0	6
100	E:E:H76	R:R:E43	11.08	No	Yes	0	0	5
101	E:E:T77	E:E:Y79	9.99	No	Yes	0	0	0
102	E:E:N78	e:e:L380	10.98	No	No	1	0	0
103	E:E:L89	E:E:Y79	11.72	Yes	Yes	0	0	0
104	E:E:K82	E:E:N80	2.8	No	Yes	0	0	0
105	E:E:F83	E:E:N80	4.83	No	Yes	0	0	0
106	E:E:N80	e:e:P381	3.26	Yes	No	0	0	0
107	E:E:E81	E:E:K84	5.4	No	No	0	0	0
108	E:E:D109	E:E:K86	12.44	Yes	No	0	0	0
109	E:E:A87	E:E:M100	3.22	No	Yes	0	0	0
110	E:E:L89	E:E:M100	4.24	Yes	Yes	3	0	0
111	E:E:F99	E:E:T90	3.89	Yes	No	0	0	0
112	E:E:D92	E:E:S94	5.89	No	No	0	0	0
113	E:E:D92	E:E:S95	7.36	No	No	0	0	0
114	E:E:S95	E:E:T97	4.8	No	No	0	0	0
115	E:E:F99	E:E:T97	6.49	Yes	No	0	0	0
116	E:E:L102	E:E:M100	5.65	Yes	Yes	3	0	0
117	E:E:M100	E:E:Y113	3.59	Yes	Yes	3	0	0
118	E:E:L102	E:E:L105	4.15	Yes	Yes	3	0	0
119	E:E:D109	E:E:L105	4.07	Yes	Yes	0	0	0
120	E:E:L105	E:E:V140	7.45	Yes	No	0	0	0
121	E:E:P107	E:E:T106	5.25	No	No	0	0	0
122	E:E:D108	E:E:T106	2.89	No	No	0	0	0
123	E:E:D109	E:E:T106	4.34	Yes	No	0	0	0
124	E:E:D109	E:E:Y113	3.45	Yes	Yes	0	0	0
125	E:E:S110	E:E:V140	3.23	No	No	0	0	0
126	E:E:A111	E:E:Y113	4	No	Yes	3	0	0
127	E:E:I112	E:E:Y114	10.88	No	Yes	0	0	0
128	E:E:I112	E:E:M137	2.92	No	No	0	0	0
129	E:E:V138	E:E:Y113	6.31	No	Yes	0	0	0
130	E:E:W132	E:E:Y114	6.75	Yes	Yes	1	0	0
131	E:E:G135	E:E:Y114	5.79	No	Yes	0	0	0
132	E:E:Y114	e:e:Q324	3.38	Yes	Yes	1	0	0
133	E:E:Y114	e:e:P330	4.17	Yes	Yes	1	0	0
134	E:E:A116	E:E:F129	2.77	No	Yes	0	0	0
135	E:E:A116	E:E:W132	6.48	No	Yes	0	0	0
136	E:E:D130	E:E:R117	14.29	No	Yes	3	0	0
137	E:E:R117	E:E:Y131	4.12	Yes	No	3	0	0
138	E:E:F129	E:E:G118	3.01	Yes	No	0	0	0
139	E:E:G120	R:R:R117	3	No	Yes	1	0	6
140	E:E:G121	E:E:T127	5.46	No	No	0	0	0
141	E:E:F122	E:E:L123	4.87	No	No	0	0	0
142	E:E:F122	R:R:Y114	11.35	No	Yes	0	0	2
143	E:E:L123	e:e:Y318	3.52	No	Yes	0	0	0
144	E:E:R124	e:e:Y318	14.4	No	Yes	0	0	0
145	E:E:R124	e:e:N378	10.85	No	No	0	0	0
146	E:E:R124	R:R:P50	11.53	No	No	0	0	5
147	E:E:I125	R:R:H46	3.98	Yes	Yes	1	0	4
148	E:E:I125	R:R:G47	5.29	Yes	No	0	0	2
149	E:E:F129	E:E:I126	3.77	Yes	No	1	0	0
150	E:E:D130	E:E:K128	9.68	No	No	0	0	0
151	E:E:K128	e:e:Y335	17.91	No	No	0	0	0
152	E:E:K128	e:e:E341	5.4	No	No	0	0	0
153	E:E:F129	e:e:H320	6.79	Yes	Yes	1	0	0
154	E:E:F129	e:e:Y322	4.13	Yes	Yes	1	0	0
155	E:E:F129	e:e:Q375	3.51	Yes	Yes	1	0	0
156	E:E:F129	e:e:Y382	3.09	Yes	Yes	1	0	0
157	E:E:D130	E:E:Y131	4.6	No	No	3	0	0
158	E:E:W132	e:e:Y322	12.54	Yes	Yes	1	0	0
159	E:E:W132	e:e:P330	14.86	Yes	Yes	1	0	0
160	E:E:M137	E:E:T139	3.01	No	No	0	0	0
161	E:E:F175	E:E:S141	5.28	Yes	No	0	0	0
162	E:E:Q144	E:E:T146	5.67	No	No	0	0	0
163	E:E:P176	E:E:T145	3.5	Yes	No	0	0	0
164	E:E:P148	E:E:Y174	6.95	No	Yes	6	0	0
165	E:E:H226	E:E:P148	9.15	Yes	No	6	0	0
166	E:E:S149	E:E:Y151	5.09	No	Yes	0	0	0
167	E:E:V150	E:E:V171	4.81	No	No	0	0	0
168	E:E:V150	E:E:V224	4.81	No	No	13	0	0
169	E:E:V150	E:E:V233	3.21	No	No	13	0	0
170	E:E:Y151	e:e:S407	5.09	Yes	No	11	0	0
171	E:E:Y151	e:e:E409	7.86	Yes	Yes	11	0	0
172	E:E:Y151	e:e:R410	18.52	Yes	Yes	11	0	0
173	E:E:Y151	e:e:T413	6.24	Yes	No	11	0	0
174	E:E:K235	E:E:P152	10.04	No	No	0	0	0
175	E:E:P152	E:E:V237	3.53	No	No	0	0	0
176	E:E:L153	e:e:F404	10.96	No	Yes	0	0	0
177	E:E:P155	e:e:F404	5.78	No	Yes	0	0	0
178	E:E:G156	E:E:S240	3.71	No	No	0	0	0
179	E:E:S162	E:E:T164	4.8	No	No	0	0	0
180	E:E:S163	E:E:T164	4.8	No	No	0	0	0
181	E:E:S163	E:E:S213	3.26	No	No	0	0	0
182	E:E:T166	E:E:T211	3.14	No	No	0	0	0
183	E:E:T166	e:e:S402	6.4	No	No	4	0	0
184	E:E:T166	e:e:F404	6.49	No	Yes	4	0	0
185	E:E:L167	E:E:W215	15.94	No	No	0	0	0
186	E:E:L167	E:E:V220	2.98	No	Yes	0	0	0
187	E:E:G168	E:E:W183	2.81	No	Yes	0	0	0
188	E:E:C169	E:E:C222	7.28	No	No	0	0	0
189	E:E:L170	E:E:T207	2.95	No	No	0	0	0
190	E:E:L170	e:e:S417	3	No	No	0	0	0
191	E:E:L206	E:E:V171	4.47	No	No	0	0	0
192	E:E:K172	E:E:T205	6.01	No	No	0	0	0
193	E:E:K172	e:e:S417	6.12	No	No	0	0	0
194	E:E:G173	E:E:L203	3.42	No	No	0	0	0
195	E:E:E177	E:E:Y174	3.37	Yes	Yes	6	0	0
196	E:E:V179	E:E:Y174	8.83	No	Yes	6	0	0
197	E:E:Y174	E:E:Y204	9.93	Yes	Yes	6	0	0
198	E:E:L206	E:E:Y174	7.03	No	Yes	0	0	0
199	E:E:H226	E:E:Y174	5.44	Yes	Yes	6	0	0
200	E:E:F175	E:E:P176	7.22	Yes	Yes	0	0	0
201	E:E:F175	E:E:Y204	3.09	Yes	Yes	0	0	0
202	E:E:P176	E:E:P178	3.9	Yes	No	0	0	0
203	E:E:H226	E:E:P176	4.58	Yes	Yes	6	0	0
204	E:E:A228	E:E:P176	3.74	No	Yes	6	0	0
205	E:E:E177	E:E:P178	4.72	Yes	No	0	0	0
206	E:E:A197	E:E:E177	3.02	No	Yes	0	0	0
207	E:E:E177	E:E:Y204	11.22	Yes	Yes	6	0	0
208	E:E:H226	E:E:V179	5.54	Yes	No	6	0	0
209	E:E:T194	E:E:V181	4.76	No	No	0	0	0
210	E:E:S208	E:E:V181	6.46	No	No	0	0	0
211	E:E:N223	E:E:T182	4.39	Yes	No	0	0	0
212	E:E:S208	E:E:W183	6.18	No	Yes	0	0	0
213	E:E:V210	E:E:W183	18.39	No	Yes	0	0	0
214	E:E:V220	E:E:W183	3.68	Yes	Yes	0	0	0
215	E:E:C222	E:E:W183	3.92	No	Yes	0	0	0
216	E:E:L188	E:E:N184	9.61	No	Yes	0	0	0
217	E:E:N184	E:E:V220	8.87	Yes	Yes	0	0	0
218	E:E:L188	E:E:S212	3	No	No	0	0	0
219	E:E:D191	E:E:H193	10.08	No	Yes	4	0	0
220	E:E:D191	E:E:T211	8.67	No	No	0	0	0
221	E:E:D191	e:e:N423	4.04	No	Yes	4	0	0
222	E:E:H193	E:E:S209	4.18	Yes	No	0	0	0
223	E:E:H193	e:e:N423	7.65	Yes	Yes	4	0	0
224	E:E:H193	e:e:N424	5.1	Yes	No	4	0	0
225	E:E:H193	e:e:D453	7.56	Yes	No	4	0	0
226	E:E:H193	e:e:S460	15.34	Yes	Yes	4	0	0
227	E:E:L206	E:E:T194	2.95	No	No	0	0	0
228	E:E:F195	E:E:S209	3.96	Yes	No	0	0	0
229	E:E:F195	e:e:S448	5.28	Yes	No	4	0	0
230	E:E:F195	e:e:T450	5.19	Yes	No	4	0	0
231	E:E:F195	e:e:S460	3.96	Yes	Yes	4	0	0
232	E:E:F195	e:e:S462	15.85	Yes	No	4	0	0
233	E:E:P196	e:e:T450	3.5	No	No	0	0	0
234	E:E:V198	e:e:L446	5.96	No	No	0	0	0
235	E:E:G202	E:E:L199	3.42	No	No	0	0	0
236	E:E:L199	E:E:Y204	14.07	No	Yes	0	0	0
237	E:E:Q200	E:E:S201	7.22	No	No	0	0	0
238	E:E:S212	E:E:T214	4.8	No	No	0	0	0
239	E:E:Q218	E:E:T214	17.01	No	No	0	0	0
240	E:E:P216	E:E:W215	13.51	No	No	0	0	0
241	E:E:Q218	E:E:S217	2.89	No	No	0	0	0
242	E:E:K236	E:E:T219	9.01	No	No	0	0	0
243	E:E:V220	E:E:V237	3.21	Yes	No	0	0	0
244	E:E:N223	E:E:T221	8.77	Yes	No	0	0	0
245	E:E:K232	E:E:N223	2.8	No	Yes	14	0	0
246	E:E:D234	E:E:N223	10.77	No	Yes	14	0	0
247	E:E:V224	E:E:V233	3.21	No	No	13	0	0
248	E:E:H226	E:E:P227	6.1	Yes	No	0	0	0
249	E:E:A228	E:E:H226	2.93	No	Yes	6	0	0
250	E:E:H226	E:E:S229	8.37	Yes	No	0	0	0
251	E:E:S229	E:E:T231	6.4	No	No	0	0	0
252	E:E:D234	E:E:K232	11.06	No	No	14	0	0
253	E:E:K235	E:E:V233	3.04	No	No	0	0	0
254	E:E:K236	E:E:V237	4.55	No	No	0	0	0
255	E:E:G238	E:E:K236	3.49	No	No	0	0	0
256	e:e:D288	e:e:P381	4.83	No	No	0	0	0
257	e:e:D288	e:e:T383	4.34	No	No	0	0	0
258	e:e:L291	e:e:T289	2.95	Yes	Yes	7	0	0
259	e:e:K313	e:e:T289	3	No	Yes	7	0	0
260	e:e:Q376	e:e:T289	8.5	Yes	Yes	7	0	0
261	e:e:E379	e:e:T289	7.06	No	Yes	7	0	0
262	e:e:C309	e:e:L291	4.76	No	Yes	7	0	0
263	e:e:A311	e:e:L291	3.15	No	Yes	0	0	0
264	e:e:C374	e:e:L291	6.35	Yes	Yes	7	0	0
265	e:e:L291	e:e:Q376	5.32	Yes	Yes	7	0	0
266	e:e:R310	e:e:T292	3.88	No	No	0	0	0
267	e:e:C309	e:e:Q293	3.05	No	Yes	7	0	0
268	e:e:C374	e:e:Q293	6.1	Yes	Yes	7	0	0
269	e:e:G385	e:e:Q293	3.29	No	Yes	0	0	0
270	e:e:G387	e:e:Q293	4.93	No	Yes	0	0	0
271	e:e:Q293	e:e:T388	8.5	Yes	No	0	0	0
272	e:e:P295	e:e:S294	5.34	No	No	0	0	0
273	e:e:S294	e:e:S308	4.89	No	No	0	0	0
274	e:e:L297	e:e:L390	2.77	No	No	0	0	0
275	e:e:A298	e:e:E391	3.02	No	No	0	0	0
276	e:e:A298	e:e:K393	3.21	No	No	0	0	0
277	e:e:Q303	e:e:V299	2.87	No	No	5	0	0
278	e:e:V299	e:e:V305	3.21	No	No	5	0	0
279	e:e:L390	e:e:V299	5.96	No	No	0	0	0
280	e:e:K393	e:e:S300	9.18	No	No	0	0	0
281	e:e:L301	e:e:P366	3.28	No	No	0	0	0
282	e:e:L301	e:e:L392	2.77	No	No	0	0	0
283	e:e:Q303	e:e:V305	2.87	No	No	5	0	0
284	e:e:K393	e:e:Q303	2.71	No	No	0	0	0
285	e:e:R304	e:e:T360	6.47	No	Yes	15	0	0
286	e:e:D362	e:e:R304	9.53	No	No	15	0	0
287	e:e:I361	e:e:V305	4.61	Yes	No	5	0	0
288	e:e:T306	e:e:T358	3.14	No	No	0	0	0
289	e:e:T306	e:e:T360	3.14	No	Yes	0	0	0
290	e:e:I307	e:e:W321	4.7	No	Yes	0	0	0
291	e:e:I307	e:e:T388	10.64	No	No	0	0	0
292	e:e:C309	e:e:C374	7.28	No	Yes	7	0	0
293	e:e:D356	e:e:R310	4.76	No	No	0	0	0
294	e:e:K313	e:e:S312	3.06	No	No	0	0	0
295	e:e:E379	e:e:K313	8.1	No	No	7	0	0
296	e:e:I319	e:e:V315	4.61	No	No	0	0	0
297	e:e:Q376	e:e:V315	2.87	Yes	No	0	0	0
298	e:e:N378	e:e:V315	5.91	No	No	0	0	0
299	e:e:S316	e:e:Y318	3.82	No	Yes	0	0	0
300	e:e:S353	e:e:T317	3.2	No	No	0	0	0
301	e:e:I377	e:e:Y318	6.04	Yes	Yes	0	0	0
302	e:e:I319	e:e:W321	3.52	No	Yes	0	0	0
303	e:e:F357	e:e:I319	15.07	No	No	0	0	0
304	e:e:H320	e:e:Y322	7.62	Yes	Yes	1	0	0
305	e:e:H320	e:e:L332	5.14	Yes	No	1	0	0
306	e:e:H320	e:e:I377	5.3	Yes	Yes	1	0	0
307	e:e:I334	e:e:W321	5.87	No	Yes	0	0	0
308	e:e:L359	e:e:W321	20.5	No	Yes	0	0	0
309	e:e:C374	e:e:W321	7.84	Yes	Yes	0	0	0
310	e:e:P330	e:e:Y322	4.17	Yes	Yes	1	0	0
311	e:e:L332	e:e:Y322	8.21	No	Yes	1	0	0
312	e:e:Q375	e:e:Y322	10.15	Yes	Yes	1	0	0
313	e:e:Q323	e:e:R325	3.5	Yes	Yes	5	0	0
314	e:e:L333	e:e:Q323	6.65	No	Yes	5	0	0
315	e:e:D368	e:e:Q323	3.92	Yes	Yes	5	0	0
316	e:e:A370	e:e:Q323	3.03	No	Yes	5	0	0
317	e:e:Q323	e:e:Y372	13.53	Yes	Yes	5	0	0
318	e:e:P330	e:e:Q324	7.9	Yes	Yes	1	0	0
319	e:e:N371	e:e:Q324	3.96	No	Yes	1	0	0
320	e:e:Q324	e:e:Y373	3.38	Yes	Yes	1	0	0
321	e:e:Q328	e:e:R325	4.67	No	Yes	0	0	0
322	e:e:D367	e:e:R325	4.76	No	Yes	0	0	0
323	e:e:A370	e:e:R325	4.15	No	Yes	5	0	0
324	e:e:K331	e:e:Q328	2.71	No	No	0	0	0
325	e:e:K331	e:e:Q329	5.42	No	No	0	0	0
326	e:e:E341	e:e:L332	6.63	No	No	0	0	0
327	e:e:L333	e:e:V344	2.98	No	Yes	5	0	0
328	e:e:F348	e:e:L333	4.87	Yes	No	5	0	0
329	e:e:I334	e:e:L340	2.85	No	No	0	0	0
330	e:e:G350	e:e:I334	3.53	No	No	0	0	0
331	e:e:N339	e:e:Y335	16.28	No	No	0	0	0
332	e:e:N339	e:e:S336	2.98	No	No	0	0	0
333	e:e:A337	e:e:F357	2.77	No	No	0	0	0
334	e:e:N339	e:e:S338	2.98	No	No	0	0	0
335	e:e:L340	e:e:V344	2.98	No	Yes	0	0	0
336	e:e:P345	e:e:V344	5.3	No	Yes	5	0	0
337	e:e:F348	e:e:V344	3.93	Yes	Yes	5	0	0
338	e:e:P345	e:e:R347	14.41	No	Yes	5	0	0
339	e:e:F348	e:e:P345	2.89	Yes	No	5	0	0
340	e:e:F348	e:e:R347	8.55	Yes	Yes	5	0	0
341	e:e:E365	e:e:R347	18.61	No	Yes	5	0	0
342	e:e:D368	e:e:R347	14.29	Yes	Yes	5	0	0
343	e:e:F348	e:e:I361	5.02	Yes	Yes	5	0	0
344	e:e:D368	e:e:F348	5.97	Yes	Yes	5	0	0
345	e:e:S349	e:e:T360	4.8	No	Yes	0	0	0
346	e:e:G352	e:e:S351	3.71	No	No	0	0	0
347	e:e:S351	e:e:T358	4.8	No	No	0	0	0
348	e:e:G354	e:e:S353	3.71	No	No	0	0	0
349	e:e:L359	e:e:Y372	3.52	No	Yes	0	0	0
350	e:e:D362	e:e:T360	2.89	No	Yes	15	0	0
351	e:e:I361	e:e:V364	3.07	Yes	No	0	0	0
352	e:e:D368	e:e:I361	2.8	Yes	Yes	5	0	0
353	e:e:I361	e:e:Y372	4.84	Yes	Yes	5	0	0
354	e:e:D368	e:e:E365	5.2	Yes	No	5	0	0
355	e:e:D368	e:e:Y372	3.45	Yes	Yes	5	0	0
356	e:e:I369	e:e:L392	4.28	No	No	0	0	0
357	e:e:N371	e:e:Y373	12.79	No	Yes	1	0	0
358	e:e:K389	e:e:N371	9.79	No	No	0	0	0
359	e:e:T388	e:e:Y372	3.75	No	Yes	0	0	0
360	e:e:L390	e:e:Y372	8.21	No	Yes	0	0	0
361	e:e:G387	e:e:Y373	2.9	No	Yes	0	0	0
362	e:e:I377	e:e:Q375	4.12	Yes	Yes	1	0	0
363	e:e:Q375	e:e:Y382	3.38	Yes	Yes	1	0	0
364	e:e:F384	e:e:Q375	23.42	No	Yes	0	0	0
365	e:e:Q376	e:e:T383	2.83	Yes	No	0	0	0
366	e:e:I377	e:e:Y382	8.46	Yes	Yes	1	0	0
367	e:e:E379	e:e:P381	3.14	No	No	0	0	0
368	e:e:E391	e:e:Y426	3.37	No	No	0	0	0
369	e:e:E391	e:e:Q452	3.82	No	No	0	0	0
370	e:e:L392	e:e:S457	7.51	No	No	0	0	0
371	e:e:A397	e:e:R394	2.77	No	Yes	0	0	0
372	e:e:R394	e:e:Y426	4.12	Yes	No	0	0	0
373	e:e:R394	e:e:T458	5.17	Yes	Yes	0	0	0
374	e:e:D396	e:e:K485	8.3	No	No	0	0	0
375	e:e:A398	e:e:T486	5.03	No	No	0	0	0
376	e:e:M422	e:e:P399	3.35	Yes	No	12	0	0
377	e:e:F425	e:e:P399	10.11	Yes	No	12	0	0
378	e:e:H484	e:e:P399	12.2	Yes	No	12	0	0
379	e:e:N423	e:e:T400	4.39	Yes	No	0	0	0
380	e:e:M422	e:e:V401	7.61	Yes	No	0	0	0
381	e:e:V401	e:e:V482	9.62	No	No	0	0	0
382	e:e:F404	e:e:S402	5.28	Yes	No	4	0	0
383	e:e:L421	e:e:S402	3	Yes	No	4	0	0
384	e:e:C420	e:e:I403	3.27	No	No	0	0	0
385	e:e:I403	e:e:K493	2.91	No	No	0	0	0
386	e:e:F495	e:e:I403	7.54	No	No	0	0	0
387	e:e:F404	e:e:P405	2.89	Yes	No	0	0	0
388	e:e:F404	e:e:L421	6.09	Yes	Yes	4	0	0
389	e:e:F495	e:e:P405	2.89	No	No	0	0	0
390	e:e:P406	e:e:V418	7.07	No	No	0	0	0
391	e:e:P406	e:e:Y472	12.52	No	Yes	0	0	0
392	e:e:E409	e:e:S407	10.06	Yes	No	11	0	0
393	e:e:R410	e:e:S407	3.95	Yes	No	11	0	0
394	e:e:E409	e:e:T408	5.64	Yes	No	0	0	0
395	e:e:R410	e:e:T413	10.35	Yes	No	11	0	0
396	e:e:G415	e:e:R410	4.5	No	Yes	0	0	0
397	e:e:K469	e:e:L411	7.05	No	No	0	0	0
398	e:e:L411	e:e:Y472	4.69	No	Yes	16	0	0
399	e:e:E473	e:e:L411	3.98	No	No	16	0	0
400	e:e:G414	e:e:K469	3.49	No	No	0	0	0
401	e:e:A416	e:e:Y472	4	No	Yes	0	0	0
402	e:e:V418	e:e:W434	3.68	No	Yes	9	0	0
403	e:e:L465	e:e:V418	4.47	No	No	9	0	0
404	e:e:L421	e:e:V419	2.98	Yes	No	0	0	0
405	e:e:T464	e:e:V419	3.17	No	No	0	0	0
406	e:e:C420	e:e:W434	5.22	No	Yes	9	0	0
407	e:e:C420	e:e:C480	7.28	No	No	9	0	0
408	e:e:L421	e:e:S462	4.5	Yes	No	4	0	0
409	e:e:F425	e:e:M422	4.98	Yes	Yes	12	0	0
410	e:e:M422	e:e:M461	4.33	Yes	No	0	0	0
411	e:e:N423	e:e:N424	8.17	Yes	No	4	0	0
412	e:e:N423	e:e:S460	2.98	Yes	Yes	4	0	0
413	e:e:N424	e:e:T458	5.85	No	Yes	4	0	0
414	e:e:F425	e:e:I430	3.77	Yes	No	12	0	0
415	e:e:F425	e:e:Y459	3.09	Yes	No	0	0	0
416	e:e:F425	e:e:H484	7.92	Yes	Yes	12	0	0
417	e:e:D429	e:e:P427	6.44	No	No	0	0	0
418	e:e:H484	e:e:P427	7.63	Yes	No	0	0	0
419	e:e:K485	e:e:P427	11.71	No	No	0	0	0
420	e:e:R428	e:e:V449	11.77	No	No	0	0	0
421	e:e:R428	e:e:Y459	13.38	No	No	0	0	0
422	e:e:I430	e:e:V482	3.07	No	No	0	0	0
423	e:e:H484	e:e:I430	9.28	Yes	No	12	0	0
424	e:e:S431	e:e:V483	4.85	No	No	0	0	0
425	e:e:S463	e:e:V432	6.46	No	No	0	0	0
426	e:e:K433	e:e:K435	8.62	Yes	No	0	0	0
427	e:e:E440	e:e:K433	6.75	No	Yes	17	0	0
428	e:e:K433	e:e:R442	9.9	Yes	No	17	0	0
429	e:e:V445	e:e:W434	7.36	No	Yes	9	0	0
430	e:e:S463	e:e:W434	6.18	No	Yes	0	0	0
431	e:e:L465	e:e:W434	5.69	No	Yes	9	0	0
432	e:e:C480	e:e:W434	5.22	No	Yes	9	0	0
433	e:e:G438	e:e:K435	5.23	No	No	0	0	0
434	e:e:K435	e:e:T479	7.51	No	No	0	0	0
435	e:e:D437	e:e:I436	5.6	No	Yes	8	0	0
436	e:e:I436	e:e:T439	3.04	Yes	No	8	0	0
437	e:e:I436	e:e:R441	6.26	Yes	No	0	0	0
438	e:e:H475	e:e:I436	5.3	Yes	Yes	8	0	0
439	e:e:D437	e:e:T439	7.23	No	No	8	0	0
440	e:e:D437	e:e:H475	12.61	No	Yes	8	0	0
441	e:e:E440	e:e:R442	12.79	No	No	17	0	0
442	e:e:D443	e:e:R441	14.29	No	No	0	0	0
443	e:e:L467	e:e:R441	3.64	No	No	0	0	0
444	e:e:D447	e:e:V445	4.38	No	No	0	0	0
445	e:e:L465	e:e:V445	2.98	No	No	9	0	0
446	e:e:D447	e:e:M461	4.16	No	No	0	0	0
447	e:e:D447	e:e:S463	2.94	No	No	0	0	0
448	e:e:S448	e:e:S462	3.26	No	No	4	0	0
449	e:e:M461	e:e:V449	4.56	No	No	0	0	0
450	e:e:S460	e:e:T450	6.4	Yes	No	4	0	0
451	e:e:Q452	e:e:S457	4.33	No	No	0	0	0
452	e:e:Q452	e:e:Y459	12.4	No	No	0	0	0
453	e:e:D453	e:e:D456	11.98	No	No	4	0	0
454	e:e:D453	e:e:T458	8.67	No	Yes	4	0	0
455	e:e:K455	e:e:S454	3.06	No	No	0	0	0
456	e:e:D456	e:e:K455	8.3	No	No	0	0	0
457	e:e:D456	e:e:T458	13.01	No	Yes	4	0	0
458	e:e:D471	e:e:L467	6.79	No	No	0	0	0
459	e:e:D471	e:e:T468	8.67	No	No	0	0	0
460	e:e:E473	e:e:Y472	3.37	No	Yes	16	0	0
461	e:e:Y472	e:e:Y478	7.94	Yes	No	0	0	0
462	e:e:H475	e:e:Y478	13.07	Yes	No	0	0	0
463	e:e:N476	e:e:N496	9.54	No	No	0	0	0
464	e:e:N476	e:e:R497	8.44	No	No	0	0	0
465	e:e:L477	e:e:T479	2.95	No	No	8	0	0
466	e:e:L477	e:e:S494	3	No	No	8	0	0
467	e:e:S494	e:e:T479	9.59	No	No	8	0	0
468	e:e:E481	e:e:V483	4.28	Yes	No	0	0	0
469	e:e:E481	e:e:P490	9.43	Yes	No	0	0	0
470	e:e:E481	e:e:V492	2.85	Yes	No	0	0	0
471	e:e:V482	e:e:V491	3.21	No	No	0	0	0
472	e:e:H484	e:e:T486	5.48	Yes	No	0	0	0
473	e:e:S487	e:e:T486	3.2	No	No	0	0	0
474	e:e:S487	e:e:S489	3.26	No	No	0	0	0
475	e:e:N498	e:e:R497	3.62	No	No	0	0	0
476	R:R:L37	R:R:V32	2.98	No	No	0	4	6
477	R:R:R40	R:R:V32	9.15	Yes	No	0	6	6
478	R:R:H36	R:R:P33	13.73	No	No	0	8	5
479	R:R:F35	R:R:V127	3.93	No	Yes	0	5	4
480	R:R:H36	R:R:R40	3.39	No	Yes	0	8	6
481	R:R:H36	R:R:L120	7.71	No	No	0	8	1
482	R:R:F38	R:R:V127	9.18	No	Yes	0	5	4
483	R:R:F38	R:R:Y279	4.13	No	Yes	0	5	5
484	R:R:L276	R:R:L41	2.77	Yes	No	0	4	5
485	R:R:L41	R:R:Y279	12.89	No	Yes	0	5	5
486	R:R:D42	R:R:W53	6.7	No	Yes	0	7	2
487	R:R:D42	R:R:R109	13.1	No	Yes	0	7	6
488	R:R:E43	R:R:Y113	5.61	Yes	Yes	1	5	6
489	R:R:E44	R:R:H272	12.31	No	No	0	4	3
490	R:R:E44	R:R:L276	3.98	No	Yes	0	4	4
491	R:R:L45	R:R:W53	7.97	No	Yes	1	4	2
492	R:R:L276	R:R:L45	8.3	Yes	No	1	4	4
493	R:R:H280	R:R:L45	25.71	Yes	No	1	5	4
494	R:R:H46	R:R:W53	22.22	Yes	Yes	1	4	2
495	R:R:H46	R:R:Y113	14.16	Yes	Yes	1	4	6
496	R:R:H46	R:R:Y114	3.27	Yes	Yes	1	4	2
497	R:R:F49	R:R:T48	7.78	No	No	0	3	2
498	R:R:H273	R:R:T48	4.11	No	No	0	3	2
499	R:R:F49	R:R:V277	3.93	No	No	0	3	2
500	R:R:L52	R:R:L56	4.15	No	No	0	3	6
501	R:R:L52	R:R:V277	2.98	No	No	0	3	2
502	R:R:L54	R:R:W53	3.42	No	Yes	0	5	2
503	R:R:M57	R:R:W53	4.65	No	Yes	1	5	2
504	R:R:F110	R:R:W53	6.01	Yes	Yes	1	7	2
505	R:R:W53	R:R:Y113	7.72	Yes	Yes	1	2	6
506	R:R:W53	R:R:Y114	4.82	Yes	Yes	1	2	2
507	R:R:H280	R:R:L56	3.86	Yes	No	0	5	6
508	R:R:L56	R:R:T284	8.84	No	No	0	6	5
509	R:R:F110	R:R:M57	14.93	Yes	No	1	7	5
510	R:R:M57	R:R:Y114	4.79	No	Yes	1	5	2
511	R:R:I63	R:R:V59	3.07	No	No	0	7	5
512	R:R:H60	R:R:L106	5.14	Yes	Yes	1	8	8
513	R:R:H60	R:R:R109	5.64	Yes	Yes	1	8	6
514	R:R:F110	R:R:H60	5.66	Yes	Yes	1	7	8
515	R:R:H60	R:R:T284	8.21	Yes	No	0	8	5
516	R:R:H60	R:R:S287	5.58	Yes	No	1	8	7
517	R:R:I63	R:R:L288	5.71	No	No	0	7	5
518	R:R:F64	R:R:L68	6.09	No	No	0	7	6
519	R:R:F64	R:R:P107	13	No	No	0	7	9
520	R:R:L70	R:R:P294	9.85	No	No	0	6	9
521	R:R:D99	R:R:N71	12.12	Yes	Yes	2	9	9
522	R:R:L100	R:R:N71	2.75	No	Yes	0	5	9
523	R:R:N71	R:R:Y297	3.49	Yes	Yes	2	9	9
524	R:R:L73	R:R:T307	2.95	No	No	0	5	5
525	R:R:A74	R:R:F78	2.77	No	Yes	0	8	6
526	R:R:A74	R:R:F304	4.16	No	Yes	0	8	8
527	R:R:L75	R:R:V96	4.47	No	No	0	7	8
528	R:R:C80	R:R:Y76	4.03	No	No	0	4	3
529	R:R:R81	R:R:Y76	8.23	No	No	0	6	3
530	R:R:T307	R:R:V77	4.76	No	No	0	5	6
531	R:R:F78	R:R:T92	5.19	Yes	Yes	2	6	8
532	R:R:F78	R:R:Y297	4.13	Yes	Yes	2	6	9
533	R:R:F78	R:R:V300	3.93	Yes	No	2	6	6
534	R:R:F78	R:R:T301	5.19	Yes	No	0	6	7
535	R:R:C79	R:R:I93	3.27	No	No	0	2	5
536	R:R:K85	R:R:V89	3.04	No	No	0	5	7
537	R:R:I90	R:R:K85	2.91	No	No	0	7	5
538	R:R:P87	R:R:T86	3.5	No	No	0	6	7
539	R:R:T86	R:R:V89	4.76	No	No	0	7	7
540	R:R:D147	R:R:P87	3.22	No	No	0	8	6
541	R:R:A167	R:R:P87	3.74	No	No	0	8	6
542	R:R:D147	R:R:S88	8.83	No	No	0	8	7
543	R:R:A167	R:R:I90	4.87	No	No	0	8	7
544	R:R:I90	R:R:R168	8.77	No	No	0	7	4
545	R:R:C143	R:R:Y91	8.06	No	Yes	0	6	7
546	R:R:D147	R:R:Y91	3.45	No	Yes	0	8	7
547	R:R:A167	R:R:Y91	4	No	Yes	0	8	7
548	R:R:V170	R:R:Y91	7.57	No	Yes	0	5	7
549	R:R:I144	R:R:T92	4.56	No	Yes	2	8	8
550	R:R:T92	R:R:Y297	3.75	Yes	Yes	2	8	9
551	R:R:T92	R:R:V300	11.11	Yes	No	2	8	6
552	R:R:F140	R:R:N94	13.29	Yes	No	2	7	9
553	R:R:C171	R:R:N94	11.02	No	No	2	7	9
554	R:R:N94	R:R:W175	6.78	No	Yes	2	9	9
555	R:R:D99	R:R:L95	2.71	Yes	Yes	2	9	9
556	R:R:L95	R:R:S137	3	Yes	Yes	2	9	9
557	R:R:L141	R:R:L95	2.77	Yes	Yes	2	8	9
558	R:R:L95	R:R:N293	2.75	Yes	Yes	2	9	9
559	R:R:L95	R:R:Y297	4.69	Yes	Yes	2	9	9
560	R:R:V96	R:R:Y297	6.31	No	Yes	0	8	9
561	R:R:C136	R:R:T98	6.76	No	No	2	6	8
562	R:R:S137	R:R:T98	3.2	Yes	No	2	9	8
563	R:R:T98	R:R:W175	6.06	No	Yes	2	8	9
564	R:R:D99	R:R:S290	2.94	Yes	No	0	9	8
565	R:R:D99	R:R:N293	12.12	Yes	Yes	2	9	9
566	R:R:D99	R:R:Y297	3.45	Yes	Yes	2	9	9
567	R:R:L101	R:R:L132	2.77	No	Yes	0	7	5
568	R:R:N133	R:R:V102	11.82	Yes	No	0	8	6
569	R:R:S290	R:R:V102	3.23	No	No	0	8	6
570	R:R:G129	R:R:S105	3.71	No	No	0	6	6
571	R:R:L106	R:R:S287	9.01	Yes	No	1	8	7
572	R:R:F110	R:R:R109	13.9	Yes	Yes	1	7	6
573	R:R:H126	R:R:R109	11.28	Yes	Yes	1	6	6
574	R:R:R109	R:R:Y130	8.23	Yes	No	1	6	6
575	R:R:Y113	R:R:Y114	9.93	Yes	Yes	1	6	2
576	R:R:R117	R:R:Y113	16.46	Yes	Yes	1	6	6
577	R:R:R117	R:R:Y114	3.09	Yes	Yes	1	6	2
578	R:R:C119	R:R:C122	5.46	No	No	18	3	9
579	R:R:A123	R:R:H126	2.93	No	Yes	0	6	6
580	R:R:F124	R:R:P125	4.33	No	No	0	4	5
581	R:R:F124	R:R:L128	10.96	No	No	0	4	5
582	R:R:H126	R:R:V127	4.15	Yes	Yes	0	6	4
583	R:R:H126	R:R:Y130	5.44	Yes	No	1	6	6
584	R:R:L128	R:R:L132	2.77	No	Yes	0	5	5
585	R:R:L128	R:R:T182	2.95	No	No	0	5	6
586	R:R:V283	R:R:Y130	5.05	No	No	0	5	6
587	R:R:F131	R:R:M134	3.73	Yes	No	0	5	7
588	R:R:F131	R:R:T182	7.78	Yes	No	19	5	6
589	R:R:F131	R:R:V185	6.55	Yes	No	0	5	4
590	R:R:F131	R:R:L186	6.09	Yes	No	19	5	4
591	R:R:L132	R:R:W175	4.56	Yes	Yes	0	5	9
592	R:R:F254	R:R:N133	4.83	No	Yes	2	9	8
593	R:R:N133	R:R:S286	5.96	Yes	No	0	8	8
594	R:R:N133	R:R:N289	10.9	Yes	Yes	2	8	9
595	R:R:L200	R:R:M134	5.65	No	No	0	5	7
596	R:R:E204	R:R:M134	10.83	No	No	0	5	7
597	R:R:H135	R:R:W139	9.52	Yes	Yes	10	8	5
598	R:R:A177	R:R:H135	2.93	No	Yes	0	4	8
599	R:R:A178	R:R:H135	5.85	No	Yes	0	7	8
600	R:R:H135	R:R:V181	5.54	Yes	No	0	8	4
601	R:R:E204	R:R:H135	14.77	No	Yes	10	5	8
602	R:R:C136	R:R:F140	4.19	No	Yes	2	6	7
603	R:R:C136	R:R:W175	5.22	No	Yes	2	6	9
604	R:R:N289	R:R:S137	2.98	Yes	Yes	2	9	9
605	R:R:N293	R:R:S137	2.98	Yes	Yes	2	9	9
606	R:R:I138	R:R:P208	3.39	No	Yes	0	8	9
607	R:R:F250	R:R:I138	10.05	Yes	No	0	9	8
608	R:R:F254	R:R:I138	11.3	No	No	0	9	8
609	R:R:T142	R:R:W139	6.06	No	Yes	10	8	5
610	R:R:E204	R:R:W139	4.36	No	Yes	10	5	5
611	R:R:L207	R:R:W139	3.42	No	Yes	10	6	5
612	R:R:P208	R:R:W139	10.81	Yes	Yes	10	9	5
613	R:R:C171	R:R:F140	4.19	No	Yes	2	7	7
614	R:R:F140	R:R:V174	9.18	Yes	No	0	7	7
615	R:R:F140	R:R:W175	6.01	Yes	Yes	2	7	9
616	R:R:L141	R:R:V246	7.45	Yes	Yes	2	8	8
617	R:R:F250	R:R:L141	6.09	Yes	Yes	2	9	8
618	R:R:L141	R:R:N293	4.12	Yes	Yes	2	8	9
619	R:R:L141	R:R:V296	4.47	Yes	No	0	8	7
620	R:R:P208	R:R:T142	3.5	Yes	No	10	9	8
621	R:R:I144	R:R:V296	3.07	No	No	0	8	7
622	R:R:I144	R:R:V300	3.07	No	No	2	8	6
623	R:R:C145	R:R:I212	4.91	No	Yes	2	9	7
624	R:R:C145	R:R:L243	3.17	No	No	2	9	7
625	R:R:C145	R:R:V246	5.12	No	Yes	2	9	8
626	R:R:L150	R:R:V146	2.98	No	No	0	6	6
627	R:R:F215	R:R:V146	5.24	Yes	No	0	7	6
628	R:R:L242	R:R:R148	3.64	No	No	0	7	9
629	R:R:V153	R:R:Y149	10.09	No	Yes	0	7	8
630	R:R:F215	R:R:Y149	16.5	Yes	Yes	0	7	8
631	R:R:R218	R:R:Y149	10.29	No	Yes	0	4	8
632	R:R:I219	R:R:Y149	4.84	No	Yes	0	7	8
633	R:R:A151	R:R:R162	2.77	No	Yes	0	8	7
634	R:R:I152	R:R:R235	5.01	No	No	0	7	5
635	R:R:I152	R:R:R236	6.26	No	Yes	0	7	6
636	R:R:C161	R:R:E156	6.08	No	No	20	4	5
637	R:R:E156	R:R:R162	11.63	No	Yes	20	5	7
638	R:R:C161	R:R:R162	6.96	No	Yes	20	4	7
639	R:R:L186	R:R:T182	2.95	No	No	19	4	6
640	R:R:G187	R:R:R192	3	No	No	0	2	2
641	R:R:S191	R:R:T189	3.2	No	No	0	4	4
642	R:R:C195	R:R:V197	3.42	No	No	0	9	5
643	R:R:Q261	R:R:V197	5.73	No	No	0	6	5
644	R:R:F205	R:R:T201	3.89	Yes	No	21	9	5
645	R:R:H258	R:R:T201	10.95	No	No	21	8	5
646	R:R:L203	R:R:V202	2.98	No	No	0	3	4
647	R:R:F205	R:R:L206	3.65	Yes	No	0	9	4
648	R:R:F205	R:R:L209	3.65	Yes	Yes	0	9	6
649	R:R:F205	R:R:T255	5.19	Yes	No	0	9	5
650	R:R:F205	R:R:H258	20.36	Yes	No	21	9	8
651	R:R:L207	R:R:P208	3.28	No	Yes	10	6	9
652	R:R:L209	R:R:L247	2.77	Yes	No	0	6	7
653	R:R:F250	R:R:L209	3.65	Yes	Yes	0	9	6
654	R:R:L209	R:R:L251	4.15	Yes	No	0	6	5
655	R:R:I212	R:R:L243	2.85	Yes	No	2	7	7
656	R:R:I212	R:R:V246	3.07	Yes	Yes	2	7	8
657	R:R:I212	R:R:L247	4.28	Yes	No	0	7	7
658	R:R:F250	R:R:I212	3.77	Yes	Yes	2	9	7
659	R:R:L243	R:R:T216	4.42	No	No	0	7	8
660	R:R:L244	R:R:T216	2.95	No	No	0	4	8
661	R:R:I219	R:R:M240	4.37	No	No	0	7	4
662	R:R:C221	R:R:R225	5.57	No	No	0	3	4
663	R:R:A222	R:R:R236	2.77	No	Yes	0	5	6
664	R:R:L223	R:R:R233	8.5	No	No	0	8	3
665	R:R:L223	R:R:V237	4.47	No	No	0	8	5
666	R:R:L229	R:R:Q231	5.32	No	Yes	0	2	4
667	R:R:H230	R:R:Q231	6.18	No	Yes	0	4	4
668	R:R:G232	R:R:Q231	4.93	No	Yes	0	3	4
669	R:R:Q231	R:R:R235	8.18	Yes	No	0	4	5
670	R:R:F299	R:R:R238	8.55	Yes	No	0	7	7
671	R:R:L244	R:R:M240	2.83	No	No	0	4	4
672	R:R:F299	R:R:Q241	5.86	Yes	No	0	7	5
673	R:R:F299	R:R:L242	8.53	Yes	No	0	7	7
674	R:R:I295	R:R:T245	3.04	No	No	0	6	4
675	R:R:F299	R:R:T245	3.89	Yes	No	0	7	4
676	R:R:F250	R:R:V246	3.93	Yes	Yes	2	9	8
677	R:R:L251	R:R:T255	2.95	No	No	0	5	5
678	R:R:C253	R:R:V252	3.42	No	No	0	7	5
679	R:R:C253	R:R:N289	4.72	No	Yes	0	7	9
680	R:R:C253	R:R:M292	3.24	No	No	0	7	7
681	R:R:F254	R:R:N289	10.87	No	Yes	2	9	9
682	R:R:P256	R:R:T255	3.5	No	No	0	9	5
683	R:R:L285	R:R:P256	3.28	No	No	0	7	9
684	R:R:F257	R:R:Q261	8.2	No	No	0	6	6
685	R:R:A282	R:R:F257	2.77	No	No	0	7	6
686	R:R:R260	R:R:S275	3.95	Yes	No	0	4	4
687	R:R:R260	R:R:Y279	13.38	Yes	Yes	0	4	5
688	R:R:L266	R:R:V262	2.98	No	No	0	4	5
689	R:R:D269	R:R:W267	7.82	No	No	0	1	2
690	R:R:M270	R:R:W267	17.45	No	No	0	3	2
691	R:R:M270	R:R:P271	3.35	No	No	0	3	2
692	R:R:M270	R:R:S275	4.6	No	No	0	3	4
693	R:R:P271	R:R:T274	5.25	No	No	0	2	2
694	R:R:H272	R:R:H273	4.78	No	No	0	3	3
695	R:R:H280	R:R:L276	3.86	Yes	Yes	1	5	4
696	R:R:H280	R:R:Y279	7.62	Yes	Yes	0	5	5
697	R:R:V283	R:R:Y279	6.31	No	Yes	0	5	5
698	R:R:N289	R:R:N293	9.54	Yes	Yes	2	9	9
699	R:R:P294	R:R:Y297	8.34	No	Yes	0	9	9
700	R:R:F304	R:R:Y297	5.16	Yes	Yes	0	8	9
701	R:R:Q305	R:R:R309	7.01	No	No	0	8	5
702	R:R:F312	R:R:H315	3.39	No	No	0	4	1
703	R:R:G316	R:R:H315	3.18	No	No	0	1	1
704	e:e:E481	e:e:K433	2.7	Yes	Yes	0	0	0
705	R:R:C171	R:R:Y91	2.69	No	Yes	0	7	7
706	E:E:A119	E:E:Y51	2.67	No	Yes	0	0	0
707	E:E:Q200	e:e:L446	2.66	No	No	0	0	0
708	E:E:F99	E:E:S40	2.64	Yes	No	0	0	0
709	R:R:R162	R:R:S158	2.64	Yes	No	0	7	5
710	R:R:F131	R:R:V127	2.62	Yes	Yes	0	5	4
711	R:R:F215	R:R:V211	2.62	Yes	No	0	7	5
712	R:R:R260	R:R:V264	2.62	Yes	No	0	4	5
713	R:R:R260	R:R:V278	2.62	Yes	No	0	4	4
714	R:R:F304	R:R:V308	2.62	Yes	No	0	8	4
715	E:E:A154	E:E:W215	2.59	No	No	0	0	0
716	R:R:F78	R:R:T82	2.59	Yes	No	0	6	5
717	e:e:H475	e:e:L477	2.57	Yes	No	8	0	0
718	R:R:F78	R:R:I93	2.51	Yes	No	0	6	5
719	E:E:T88	E:E:Y79	2.5	No	Yes	0	0	0
720	R:R:H258	R:R:Q261	2.47	No	No	0	8	6
721	E:E:V192	E:E:W183	2.45	No	Yes	0	0	0
722	R:R:V97	R:R:W175	2.45	No	Yes	0	5	9
723	R:R:F64	R:R:L65	2.44	No	No	0	7	5
724	R:R:F198	R:R:L266	2.44	No	No	0	4	4
725	R:R:L228	R:R:R236	2.43	No	Yes	0	4	6
726	E:E:K84	E:E:Y79	2.39	No	Yes	0	0	0
727	R:R:F198	R:R:R196	2.14	No	No	0	4	3
728	R:R:R159	R:R:R160	2.13	No	No	0	5	4
729	E:E:G73	R:R:G118	2.11	No	No	0	0	7
730	E:E:G120	E:E:G121	2.11	No	No	0	0	0
731	E:E:G238	E:E:G239	2.11	No	No	0	0	0
732	e:e:G414	e:e:G415	2.11	No	No	0	0	0
733	e:e:G302	e:e:P363	2.03	No	No	0	0	0
734	R:R:G51	R:R:P50	2.03	No	No	0	3	5
735	R:R:G227	R:R:P226	2.03	No	No	0	4	5
736	e:e:A386	e:e:G387	1.95	No	No	0	0	0
737	R:R:A66	R:R:G67	1.95	No	No	0	5	8
738	R:R:A178	R:R:G179	1.95	No	No	0	7	3
739	R:R:A306	R:R:G303	1.95	No	No	0	4	6
740	E:E:A147	E:E:P148	1.87	No	No	0	0	0
741	E:E:G45	E:E:S44	1.86	No	No	0	0	0
742	E:E:G241	E:E:S240	1.86	No	No	0	0	0
743	e:e:G354	e:e:S314	1.86	No	No	0	0	0
744	e:e:G350	e:e:S351	1.86	No	No	0	0	0
745	R:R:G157	R:R:S158	1.86	No	No	0	5	5
746	E:E:G73	E:E:T49	1.82	No	No	0	0	0
747	E:E:G61	E:E:T60	1.82	No	No	0	0	0
748	E:E:G186	E:E:T182	1.82	No	No	0	0	0
749	R:R:C79	R:R:C80	1.82	No	No	0	2	4
750	R:R:G217	R:R:T216	1.82	No	No	0	2	8
751	R:R:G303	R:R:T301	1.82	No	No	0	6	7
752	R:R:A66	R:R:C291	1.81	No	No	0	5	6
753	R:R:A116	R:R:C119	1.81	No	No	18	4	3
754	R:R:A116	R:R:C122	1.81	No	No	18	4	9
755	E:E:P155	E:E:V165	1.77	No	No	0	0	0
756	R:R:P125	R:R:T108	1.75	No	No	0	5	6
757	R:R:G217	R:R:M220	1.75	No	No	0	2	4
758	E:E:G173	E:E:K172	1.74	No	No	0	0	0
759	E:E:A31	E:E:S35	1.71	No	No	0	0	0
760	E:E:A143	E:E:S141	1.71	No	No	0	0	0
761	E:E:G202	E:E:L203	1.71	No	No	0	0	0
762	R:R:G103	R:R:L106	1.71	No	Yes	0	5	8
763	R:R:C122	R:R:V112	1.71	No	No	0	9	5
764	R:R:G129	R:R:L132	1.71	No	Yes	0	6	5
765	R:R:C166	R:R:V170	1.71	No	No	0	3	5
766	R:R:G187	R:R:L186	1.71	No	No	0	2	4
767	R:R:G67	R:R:N71	1.7	No	Yes	0	8	9
768	R:R:A123	R:R:V112	1.7	No	No	0	6	5
769	E:E:A225	E:E:T180	1.68	No	No	0	0	0
770	e:e:A470	e:e:T468	1.68	No	No	0	0	0
771	R:R:A84	R:R:T86	1.68	No	No	0	5	7
772	E:E:K32	E:E:P33	1.67	No	No	0	0	0
773	E:E:G63	E:E:Q62	1.64	No	No	0	0	0
774	R:R:C291	R:R:I63	1.64	No	No	0	6	7
775	R:R:L106	R:R:P107	1.64	Yes	No	0	8	9
776	E:E:S26	E:E:S40	1.63	No	No	0	0	0
777	e:e:S417	e:e:S466	1.63	No	No	0	0	0
778	E:E:V198	e:e:S448	1.62	No	No	0	0	0
779	e:e:S312	e:e:V290	1.62	No	No	0	0	0
780	E:E:A225	E:E:K232	1.61	No	No	0	0	0
781	e:e:A296	e:e:K389	1.61	No	No	0	0	0
782	E:E:S213	E:E:T214	1.6	No	No	0	0	0
783	e:e:S316	e:e:T317	1.6	No	No	0	0	0
784	R:R:V277	R:R:V281	1.6	No	No	0	2	5
785	e:e:T292	e:e:V290	1.59	No	No	0	0	0
786	R:R:G61	R:R:H60	1.59	No	Yes	0	5	8
787	R:R:C161	R:R:L150	1.59	No	No	0	4	6
788	R:R:T201	R:R:V262	1.59	No	No	0	5	5
789	R:R:G313	R:R:H317	1.59	No	No	0	4	4
790	R:R:P164	R:R:Q163	1.58	No	No	0	3	6
791	R:R:E31	R:R:P193	1.57	No	No	0	7	4
792	E:E:A187	E:E:N184	1.56	No	Yes	0	0	0
793	R:R:I248	R:R:V252	1.54	No	No	0	4	5
794	R:R:I249	R:R:V296	1.54	No	No	0	6	7
795	R:R:C166	R:R:Q163	1.53	No	No	0	3	6
796	E:E:K93	E:E:V91	1.52	No	No	0	0	0
797	E:E:A143	E:E:Q144	1.52	No	No	0	0	0
798	R:R:I249	R:R:T245	1.52	No	No	0	6	4
799	e:e:A412	e:e:E409	1.51	No	Yes	0	0	0
800	R:R:F312	R:R:G313	1.51	No	No	0	4	4
801	E:E:N223	E:E:S185	1.49	Yes	No	0	0	0
802	R:R:L73	R:R:V308	1.49	No	No	0	5	4
803	e:e:D471	e:e:S474	1.47	No	No	0	0	0
804	E:E:N184	E:E:T221	1.46	Yes	No	0	0	0
805	R:R:G115	R:R:Y114	1.45	No	Yes	0	4	2
806	R:R:P155	R:R:R154	1.44	No	No	0	8	6
807	R:R:P193	R:R:R192	1.44	No	No	0	4	2
808	R:R:P226	R:R:R225	1.44	No	No	0	5	4
809	R:R:Q305	R:R:S302	1.44	No	No	0	8	6
810	R:R:C298	R:R:F304	1.4	No	Yes	0	7	8
811	R:R:A265	R:R:F198	1.39	No	No	0	4	4
812	e:e:A395	e:e:R394	1.38	No	Yes	0	0	0
813	R:R:L104	R:R:L68	1.38	No	No	0	5	6
814	R:R:L311	R:R:L73	1.38	No	No	0	4	5
815	R:R:A239	R:R:R148	1.38	No	No	0	7	9
816	R:R:P268	R:R:W267	1.35	No	No	0	4	2
817	R:R:R225	R:R:S224	1.32	No	No	0	4	4
818	R:R:R154	R:R:V153	1.31	No	No	0	6	7
819	R:R:F215	R:R:V214	1.31	Yes	No	0	7	4
820	e:e:R310	e:e:T355	1.29	No	No	0	0	0
821	E:E:Q20	E:E:Q22	1.28	No	No	0	0	0
822	R:R:I152	R:R:R148	1.25	No	No	0	7	9
823	R:R:I219	R:R:R236	1.25	No	Yes	0	7	6
824	R:R:F38	R:R:L34	1.22	No	No	0	5	4
825	R:R:L223	R:R:R236	1.21	No	Yes	0	8	6
826	R:R:L228	R:R:R233	1.21	No	No	0	4	3
827	R:R:F304	R:R:Q305	1.17	Yes	No	0	8	8
828	e:e:E473	e:e:R497	1.16	No	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	E:E:Q25	5.39	6	3	0
2	E:E:I39	5.012	5	3	0
3	E:E:Y46	7.3525	4	3	0
4	E:E:F48	6.9	4	0	0
5	E:E:Y51	6.97	4	3	0
6	E:E:Y52	8.29429	7	1	0
7	E:E:W55	10.09	4	3	0
8	E:E:K57	6.17333	6	3	0
9	E:E:Y66	8.742	5	1	0
10	E:E:I67	8.19	4	3	0
11	E:E:F69	5.06571	7	1	0
12	E:E:N71	7.288	5	1	0
13	E:E:Y79	6.65	4	0	0
14	E:E:N80	4.175	4	0	0
15	E:E:L89	7.1975	4	3	0
16	E:E:F99	6.3575	4	0	0
17	E:E:M100	6.91857	7	3	0
18	E:E:L102	4.28	4	3	0
19	E:E:L105	4.6625	4	3	0
20	E:E:D109	6.075	4	0	0
21	E:E:Y113	5.48667	6	3	0
22	E:E:Y114	6.47667	6	1	0
23	E:E:C115	6.0975	4	3	0
24	E:E:R117	9.3	6	3	0
25	E:E:I125	5.375	4	1	0
26	E:E:F129	4.04375	8	1	0
27	E:E:W132	9.066	5	1	0
28	E:E:Y151	8.56	5	11	0
29	E:E:Y174	6.925	6	6	0
30	E:E:F175	5.42	4	0	0
31	E:E:P176	4.588	5	6	0
32	E:E:E177	5.5825	4	6	0
33	E:E:W183	6.23833	6	0	0
34	E:E:N184	5.375	4	0	0
35	E:E:H193	8.31833	6	4	0
36	E:E:F195	6.848	5	4	0
37	E:E:Y204	9.5775	4	6	0
38	E:E:V220	4.685	4	0	0
39	E:E:N223	5.644	5	14	0
40	E:E:H226	6.01571	7	6	0
41	e:e:T289	5.3775	4	7	0
42	e:e:L291	4.506	5	7	0
43	e:e:Q293	5.174	5	7	0
44	e:e:Y318	6.945	4	0	0
45	e:e:H320	6.2125	4	1	0
46	e:e:W321	8.486	5	0	0
47	e:e:Y322	7.80333	6	1	0
48	e:e:Q323	6.126	5	5	0
49	e:e:Q324	5.516	5	1	0
50	e:e:R325	4.27	4	5	0
51	e:e:P330	7.775	4	1	0
52	e:e:V344	3.7975	4	5	0
53	e:e:R347	13.965	4	5	0
54	e:e:F348	5.205	6	5	0
55	e:e:T360	4.325	4	15	0
56	e:e:I361	4.068	5	5	0
57	e:e:D368	5.93833	6	5	0
58	e:e:Y372	6.21667	6	5	0
59	e:e:Y373	6.82	4	1	0
60	e:e:C374	6.8925	4	7	0
61	e:e:Q375	8.916	5	1	0
62	e:e:Q376	4.88	4	7	0
63	e:e:I377	5.98	4	1	0
64	e:e:Y382	8.945	4	1	0
65	e:e:R394	3.36	4	0	0
66	e:e:F404	6.24833	6	4	0
67	e:e:E409	6.2675	4	11	0
68	e:e:R410	9.33	4	11	0
69	e:e:L421	4.1425	4	4	0
70	e:e:M422	5.0675	4	12	0
71	e:e:N423	5.446	5	4	0
72	e:e:F425	5.974	5	12	0
73	e:e:K433	6.9925	4	17	0
74	e:e:W434	5.55833	6	9	0
75	e:e:I436	5.05	4	8	0
76	e:e:T458	8.175	4	4	0
77	e:e:S460	7.17	4	4	0
78	e:e:Y472	6.504	5	16	0
79	e:e:H475	8.3875	4	8	0
80	e:e:E481	4.815	4	0	0
81	e:e:H484	8.502	5	12	0
82	R:R:R40	5.1075	4	0	6
83	R:R:E43	8.248	5	1	5
84	R:R:H46	10.9075	4	1	4
85	R:R:W53	7.93875	8	1	2
86	R:R:H60	5.30333	6	1	8
87	R:R:N71	5.015	4	2	9
88	R:R:F78	3.75857	7	2	6
89	R:R:Y91	5.154	5	0	7
90	R:R:T92	6.1525	4	2	8
91	R:R:L95	3.184	5	2	9
92	R:R:D99	6.668	5	2	9
93	R:R:L106	4.375	4	1	8
94	R:R:R109	10.43	5	1	6
95	R:R:F110	10.125	4	1	7
96	R:R:Y113	10.776	5	1	6
97	R:R:Y114	5.52857	7	1	2
98	R:R:R117	8.21	4	1	6
99	R:R:H126	5.95	4	1	6
100	R:R:V127	4.97	4	0	4
101	R:R:F131	5.354	5	19	5
102	R:R:L132	2.9525	4	0	5
103	R:R:N133	8.3775	4	2	8
104	R:R:H135	7.722	5	10	8
105	R:R:S137	3.04	4	2	9
106	R:R:W139	6.834	5	10	5
107	R:R:F140	7.372	5	2	7
108	R:R:L141	4.98	5	2	8
109	R:R:Y149	10.43	4	0	8
110	R:R:R162	6	4	20	7
111	R:R:W175	5.18	6	2	9
112	R:R:F205	7.348	5	21	9
113	R:R:P208	5.245	4	10	9
114	R:R:L209	3.555	4	0	6
115	R:R:I212	3.776	5	2	7
116	R:R:F215	6.4175	4	0	7
117	R:R:Q231	6.1525	4	0	4
118	R:R:R236	2.784	5	0	6
119	R:R:V246	4.8925	4	2	8
120	R:R:F250	5.498	5	2	9
121	R:R:R260	5.6425	4	0	4
122	R:R:L276	4.7275	4	1	4
123	R:R:Y279	8.866	5	0	5
124	R:R:H280	10.2625	4	1	5
125	R:R:N289	7.802	5	2	9
126	R:R:N293	6.302	5	2	9
127	R:R:Y297	4.915	8	2	9
128	R:R:F299	6.7075	4	0	7
129	R:R:F304	2.902	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	E:E:I112	E:E:M137	51.5624	2.92	No	No	0	0	0
2	E:E:I112	E:E:Y114	52.1433	10.88	No	Yes	0	0	0
3	E:E:L30	E:E:T139	49.8188	2.95	No	No	0	0	0
4	E:E:M137	E:E:T139	50.4001	3.01	No	No	0	0	0
5	E:E:F175	E:E:L30	49.2374	6.09	Yes	No	0	0	0
6	E:E:I125	E:E:Y52	10.5384	8.46	Yes	Yes	1	0	0
7	E:E:I126	E:E:Y52	48.6494	9.67	No	Yes	1	0	0
8	E:E:Y52	R:R:R117	25.7291	10.29	Yes	Yes	1	0	6
9	E:E:W132	E:E:Y114	33.4495	6.75	Yes	Yes	1	0	0
10	E:E:W132	e:e:Y322	16.9765	12.54	Yes	Yes	1	0	0
11	E:E:F129	e:e:Y322	38.4246	4.13	Yes	Yes	1	0	0
12	e:e:Q324	e:e:Y373	13.094	3.38	Yes	Yes	1	0	0
13	E:E:Y114	e:e:P330	16.8056	4.17	Yes	Yes	1	0	0
14	e:e:P330	e:e:Y322	21.2921	4.17	Yes	Yes	1	0	0
15	E:E:A116	E:E:F129	16.8537	2.77	No	Yes	0	0	0
16	E:E:A116	E:E:W132	16.7956	6.48	No	Yes	0	0	0
17	E:E:F122	R:R:Y114	47.3207	11.35	No	Yes	0	0	2
18	R:R:E43	R:R:Y113	11.9235	5.61	Yes	Yes	1	5	6
19	R:R:R117	R:R:Y114	15.5572	3.09	Yes	Yes	1	6	2
20	E:E:L123	e:e:Y318	47.3931	3.52	No	Yes	0	0	0
21	E:E:R124	e:e:Y318	46.829	14.4	No	Yes	0	0	0
22	E:E:R124	e:e:N378	46.7464	10.85	No	No	0	0	0
23	E:E:I125	R:R:H46	24.0419	3.98	Yes	Yes	1	0	4
24	E:E:Y174	E:E:Y204	32.2955	9.93	Yes	Yes	6	0	0
25	E:E:F175	E:E:Y204	39.8847	3.09	Yes	Yes	0	0	0
26	e:e:G414	e:e:G415	10.8996	2.11	No	No	0	0	0
27	e:e:G414	e:e:K469	11.8072	3.49	No	No	0	0	0
28	e:e:K469	e:e:L411	12.7147	7.05	No	No	0	0	0
29	e:e:L411	e:e:Y472	13.6178	4.69	No	Yes	16	0	0
30	e:e:P406	e:e:Y472	43.5009	12.52	No	Yes	0	0	0
31	e:e:P406	e:e:V418	44.4044	7.07	No	No	0	0	0
32	e:e:V418	e:e:W434	30.2429	3.68	No	Yes	9	0	0
33	e:e:V445	e:e:W434	16.89	7.36	No	Yes	9	0	0
34	e:e:D447	e:e:V445	32.5477	4.38	No	No	0	0	0
35	e:e:D447	e:e:M461	50.326	4.16	No	No	0	0	0
36	e:e:M422	e:e:M461	25.4334	4.33	Yes	No	0	0	0
37	e:e:F425	e:e:M422	25.5887	4.98	Yes	Yes	12	0	0
38	e:e:F425	e:e:Y459	27.6182	3.09	Yes	No	0	0	0
39	e:e:Q452	e:e:Y459	53.2208	12.4	No	No	0	0	0
40	e:e:E391	e:e:Q452	54.028	3.82	No	No	0	0	0
41	e:e:A298	e:e:E391	69.5989	3.02	No	No	0	0	0
42	e:e:A298	e:e:K393	69.7214	3.21	No	No	0	0	0
43	e:e:K393	e:e:Q303	69.9662	2.71	No	No	0	0	0
44	e:e:Q303	e:e:V299	34.6974	2.87	No	No	5	0	0
45	e:e:L390	e:e:V299	34.7447	5.96	No	No	0	0	0
46	e:e:L390	e:e:Y372	34.8402	8.21	No	Yes	0	0	0
47	e:e:T388	e:e:Y372	21.431	3.75	No	Yes	0	0	0
48	e:e:Q293	e:e:T388	21.3573	8.5	Yes	No	0	0	0
49	e:e:G387	e:e:Q293	16.6934	4.93	No	Yes	0	0	0
50	e:e:G387	e:e:Y373	17.4409	2.9	No	Yes	0	0	0
51	e:e:L465	e:e:V418	15.0648	4.47	No	No	9	0	0
52	e:e:L465	e:e:V445	15.3635	2.98	No	No	9	0	0
53	e:e:S463	e:e:W434	16.8949	6.18	No	Yes	0	0	0
54	e:e:D447	e:e:S463	17.4887	2.94	No	No	0	0	0
55	e:e:M461	e:e:V449	25.1874	4.56	No	No	0	0	0
56	e:e:R428	e:e:V449	25.3282	11.77	No	No	0	0	0
57	e:e:R428	e:e:Y459	25.4717	13.38	No	No	0	0	0
58	e:e:Q303	e:e:V305	35.3909	2.87	No	No	5	0	0
59	e:e:I361	e:e:V305	35.4399	4.61	Yes	No	5	0	0
60	e:e:I361	e:e:Y372	34.9342	4.84	Yes	Yes	5	0	0
61	E:E:L206	E:E:Y174	29.9843	7.03	No	Yes	0	0	0
62	E:E:L206	E:E:T194	22.9343	2.95	No	No	0	0	0
63	E:E:T194	E:E:V181	22.3482	4.76	No	No	0	0	0
64	E:E:S208	E:E:V181	21.7621	6.46	No	No	0	0	0
65	E:E:S208	E:E:W183	21.1759	6.18	No	Yes	0	0	0
66	E:E:V220	E:E:W183	17.6582	3.68	Yes	Yes	0	0	0
67	e:e:R394	e:e:T458	15.2093	5.17	Yes	Yes	0	0	0
68	e:e:R394	e:e:Y426	15.6973	4.12	Yes	No	0	0	0
69	e:e:E391	e:e:Y426	15.8604	3.37	No	No	0	0	0
70	E:E:N184	E:E:V220	11.7891	8.87	Yes	Yes	0	0	0
71	e:e:N378	e:e:V315	46.7216	5.91	No	No	0	0	0
72	e:e:I319	e:e:V315	46.4679	4.61	No	No	0	0	0
73	e:e:L359	e:e:W321	48.9248	20.5	No	Yes	0	0	0
74	e:e:L359	e:e:Y372	48.9241	3.52	No	Yes	0	0	0
75	e:e:Y472	e:e:Y478	23.5953	7.94	Yes	No	0	0	0
76	e:e:H475	e:e:Y478	22.6892	13.07	Yes	No	0	0	0
77	e:e:H475	e:e:L477	11.8072	2.57	Yes	No	8	0	0
78	R:R:W53	R:R:Y113	22.2716	7.72	Yes	Yes	1	2	6
79	R:R:D42	R:R:W53	40.9538	6.7	No	Yes	0	7	2
80	R:R:D42	R:R:R109	40.8057	13.1	No	Yes	0	7	6
81	R:R:H126	R:R:R109	100	11.28	Yes	Yes	1	6	6
82	R:R:H126	R:R:V127	97.6928	4.15	Yes	Yes	0	6	4
83	R:R:F110	R:R:W53	42.7445	6.01	Yes	Yes	1	7	2
84	R:R:F110	R:R:R109	60.2331	13.9	Yes	Yes	1	7	6
85	R:R:M57	R:R:Y114	20.4349	4.79	No	Yes	1	5	2
86	R:R:F131	R:R:V127	97.3516	2.62	Yes	Yes	0	5	4
87	R:R:F131	R:R:T182	51.1567	7.78	Yes	No	19	5	6
88	R:R:L128	R:R:T182	50.8031	2.95	No	No	0	5	6
89	R:R:L128	R:R:L132	49.2702	2.77	No	Yes	0	5	5
90	R:R:L132	R:R:W175	47.7359	4.56	Yes	Yes	0	5	9
91	R:R:T98	R:R:W175	28.4025	6.06	No	Yes	2	8	9
92	R:R:S137	R:R:T98	28.5325	3.2	Yes	No	2	9	8
93	R:R:L95	R:R:S137	20.8474	3	Yes	Yes	2	9	9
94	R:R:L95	R:R:Y297	15.9366	4.69	Yes	Yes	2	9	9
95	R:R:F131	R:R:M134	43.481	3.73	Yes	No	0	5	7
96	R:R:E204	R:R:M134	42.6816	10.83	No	No	0	5	7
97	R:R:E204	R:R:W139	40.234	4.36	No	Yes	10	5	5
98	R:R:P208	R:R:W139	39.0715	10.81	Yes	Yes	10	9	5
99	R:R:I138	R:R:P208	38.7051	3.39	No	Yes	0	8	9
100	R:R:F250	R:R:I138	34.2458	10.05	Yes	No	0	9	8
101	R:R:C171	R:R:Y91	18.4168	2.69	No	Yes	0	7	7
102	R:R:F140	R:R:W175	10.2711	6.01	Yes	Yes	2	7	9
103	R:R:F250	R:R:I212	16.3565	3.77	Yes	Yes	2	9	7
104	R:R:I212	R:R:L243	15.5513	2.85	Yes	No	2	7	7
105	R:R:L243	R:R:T216	15.502	4.42	No	No	0	7	8
106	R:R:L244	R:R:T216	14.1544	2.95	No	No	0	4	8
107	R:R:L244	R:R:M240	13.7056	2.83	No	No	0	4	4
108	R:R:I219	R:R:M240	13.2571	4.37	No	No	0	7	4
109	E:E:F129	E:E:I126	60.4141	3.77	Yes	No	1	0	0
110	E:E:F122	E:E:L123	47.3511	4.87	No	No	0	0	0
111	E:E:F69	E:E:I126	11.804	5.02	Yes	No	1	0	0
112	e:e:I319	e:e:W321	46.4621	3.52	No	Yes	0	0	0
113	E:E:F69	E:E:I125	14.4112	3.77	Yes	Yes	1	0	0
114	R:R:H46	R:R:W53	23.9989	22.22	Yes	Yes	1	4	2
115	E:E:Y52	R:R:E43	10.5496	6.73	Yes	Yes	1	0	5
116	R:R:R117	R:R:Y113	10.4047	16.46	Yes	Yes	1	6	6
117	R:R:W53	R:R:Y114	42.0765	4.82	Yes	Yes	1	2	2
118	R:R:F110	R:R:M57	20.3574	14.93	Yes	No	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HS2

PDB Summary
PDB	8HS2
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR20
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	Fab046
PDB Resolution	3.08
Date	2023-03-08
D.O.I.	doi.org/10.1038/s41421-023-00520-8

Net Summary
I_min	2.71
Number of Linked Nodes	673
Number of Links	828
Number of Hubs	129
Number of Links mediated by Hubs	477
Number of Communities	21
Number of Nodes involved in Communities	192
Number of Links involved in Communities	287

Path Summary
Number Of Nodes in MetaPath	119
Number Of Links MetaPath	118
Number of Shortest Paths	2572334
Length Of Smallest Path	3
Average Path Length	33.8861
Length of Longest Path	63
Minimum Path Strength	1.23
Average Path Strength	6.17183
Maximum Path Strength	19.015
Minimum Path Correlation	0.7
Average Path Correlation	0.988578
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	47.7435
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.91
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99678
Sequence	>8HS2_Chain_R E V P L F H L F A R L D E E L H G T F P G L W L A L M A V H G A I F L A G L V L N G L A L Y V F C C R T R A K T P S V I Y T I N L V V T D L L V G L S L P T R F A V Y Y G A R G C L R C A F P H V L G Y F L N M H C S I W F L T C I C V D R Y L A I V R P E G S R R C R Q P A C A R A V C A F V W L A A G A V T L S V L G V T G S R P C C R V F A L T V L E F L L P L L V I S V F T G R I M C A L S R P G L L H Q G R Q R R V R A M Q L L L T V L I I F L V C F T P F H A R Q V A V A L W P D M P H H T S L V V Y H V A V T L S S L N S C M N P I V Y C F V T S G F Q A T V R G L F G Q H G H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HS2	A	Orphan	Orphan	GPR20	Homo sapiens	-	-	Fab046	3.08	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HS3	A	Orphan	Orphan	GPR20	Homo sapiens	-	-	Gi1/β1/γ2	3.14	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HS3 (No Gprot)	A	Orphan	Orphan	GPR20	Homo sapiens	-	-		3.14	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HSC	A	Orphan	Orphan	GPR20	Homo sapiens	-	-	Gi1/β1/γ2; Fab046	3.22	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HSC (No Gprot)	A	Orphan	Orphan	GPR20	Homo sapiens	-	-		3.22	2023-03-08	doi.org/10.1038/s41421-023-00520-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HS2.zip

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