Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1M:M:T289 5.798520
2M:M:L291 3.31833620
3M:M:Q293 4.87667620
4M:M:V305 3.1450
5M:M:I307 5.2775400
6M:M:C309 4.425420
7M:M:Y318 6.758520
8M:M:I319 4.914520
9M:M:H320 4.112520
10M:M:W321 5.44667620
11M:M:Y322 6.182520
12M:M:Q323 3.4775420
13M:M:Q329 4.8725420
14M:M:P330 5.345420
15M:M:Y335 9.615420
16M:M:L340 2.58400
17M:M:E341 7.5975420
18M:M:V344 2.94754100
19M:M:L359 5.83520
20M:M:Y372 3.248520
21M:M:Y373 5.705420
22M:M:C374 4.505620
23M:M:Q375 8.7525420
24M:M:Q376 6.2420
25M:M:E379 5.1575420
26M:M:P381 2.4075400
27M:M:Y382 8.63420
28M:M:F384 6.445420
29M:M:G387 3.645420
30A:A:V34 5.584515
31A:A:L36 4.09417
32A:A:L37 4.442519
33A:A:K46 5.862519
34A:A:I184 4.5475419
35A:A:F189 6.91419
36A:A:F191 6.685415
37A:A:F196 6.88333617
38A:A:K197 7.58416
39A:A:M198 4.1825417
40A:A:F199 7.962515
41A:A:D200 3.205419
42A:A:V201 4.912519
43A:A:Q204 3.90667619
44A:A:S206 3.195418
45A:A:R208 4.8525419
46A:A:K210 7.135419
47A:A:W211 4.87719
48A:A:I212 3.246518
49A:A:H213 7.4025418
50A:A:C214 3.6375417
51A:A:F215 5.24819
52A:A:E216 4.3425417
53A:A:A220 2.055408
54A:A:I221 4.405418
55A:A:F223 4.146519
56A:A:L227 6.5375417
57A:A:Y230 5.37875818
58A:A:D231 7.955419
59A:A:M243 3.1225418
60A:A:H244 4.0125414
61A:A:M247 3.8475416
62A:A:F250 6.51333619
63A:A:C254 4.095615
64A:A:W258 4.915615
65A:A:F259 4.59714719
66A:A:T262 3.1425417
67A:A:I264 3.324516
68A:A:I265 3.285418
69A:A:L266 3.132519
70A:A:F267 3.53429719
71A:A:F274 5.156519
72A:A:S281 4.375417
73A:A:P282 4.2725415
74A:A:L283 4.4975407
75A:A:C286 4.09516
76A:A:Y287 6.37143717
77A:A:Y290 7.525407
78A:A:I303 4.426517
79A:A:Q304 6.68415
80A:A:F307 4.45333618
81A:A:N311 5.7875418
82A:A:I319 4.192515
83A:A:Y320 5.555817
84A:A:F323 3.954514
85A:A:N331 7.4725418
86A:A:F334 5.44513
87A:A:F336 5.25518
88A:A:V339 4.4825418
89A:A:V342 2.5225417
90A:A:I344 2.9925426
91A:A:L348 3.25429
92A:A:C351 1.91524
93A:A:L353 4.138527
94B:B:L14 4.5525408
95B:B:L30 4.305405
96B:B:T34 4.45415
97B:B:I37 3.8375402
98B:B:V40 3.83143713
99B:B:I43 3.38413
100B:B:M45 4.152514
101B:B:R48 5.10667617
102B:B:L51 7.7419
103B:B:H54 7.98857719
104B:B:I58 3.9075419
105B:B:Y59 7.445618
106B:B:M61 3.98833616
107B:B:W63 6.04143717
108B:B:L70 5.748515
109B:B:V71 4.22518
110B:B:D76 5.602519
111B:B:L79 3.28714717
112B:B:I81 4.8617
113B:B:W82 10.4067619
114B:B:N88 4.34754117
115B:B:K89 6.422519
116B:B:H91 6.295415
117B:B:I93 7.16417
118B:B:L95 4.874518
119B:B:W99 8.37429719
120B:B:C103 2.6075418
121B:B:Y105 4.46429716
122B:B:S108 4.59416
123B:B:N110 6.8575414
124B:B:Y111 7.074514
125B:B:A113 2.135619
126B:B:C114 3.505618
127B:B:G115 2.8175419
128B:B:G116 1.8125419
129B:B:L117 3.41429719
130B:B:C121 2.80167618
131B:B:S122 3.9325418
132B:B:I123 3.69667616
133B:B:Y124 5.49429716
134B:B:E130 2.8775473
135B:B:L139 4.766509
136B:B:H142 5.98125819
137B:B:G144 2.5675418
138B:B:Y145 4.25875818
139B:B:L146 2.99667617
140B:B:C148 3.065436
141B:B:C149 2.855618
142B:B:F151 4.865619
143B:B:L152 3.134533
144B:B:Q156 5.16405
145B:B:I157 3.29429717
146B:B:V158 3.3535
147B:B:T159 4.42571719
148B:B:S160 3.536536
149B:B:S161 7.69419
150B:B:D163 6.358519
151B:B:T165 4.8375417
152B:B:C166 3.09167638
153B:B:A167 3.965414
154B:B:L168 4.99667636
155B:B:W169 10.252518
156B:B:I171 4.46416
157B:B:Q176 6.866514
158B:B:T178 5.745434
159B:B:F180 6.33286737
160B:B:H183 7.10714739
161B:B:D186 3.23833619
162B:B:V187 3.808539
163B:B:L190 3.35535
164B:B:L192 3.33435
165B:B:F199 6.47333639
166B:B:V200 5.25546
167B:B:S201 4.2175439
168B:B:C204 6.72417
169B:B:D205 5.936539
170B:B:A208 2.005446
171B:B:K209 13.2975436
172B:B:L210 5.114505
173B:B:W211 8.225638
174B:B:D212 5.89409
175B:B:V213 4.375634
176B:B:R214 4.4375409
177B:B:C218 4.51435
178B:B:Q220 6.914547
179B:B:F222 5.63548
180B:B:H225 7.025849
181B:B:I232 3.868548
182B:B:F234 6.1975445
183B:B:F235 6.44429716
184B:B:P236 5.6675417
185B:B:N237 5.74415
186B:B:F241 4.98375846
187B:B:T243 5.15648
188B:B:D247 6.536549
189B:B:T249 5.09646
190B:B:C250 2.93167618
191B:B:R251 11.338548
192B:B:F253 6.82167646
193B:B:R256 9.955409
194B:B:D258 8.9225447
195B:B:Q259 4.3475466
196B:B:E260 9.5525446
197B:B:L261 3.136565
198B:B:T263 5.6441
199B:B:Y264 5.16667615
200B:B:H266 3.5025414
201B:B:I269 3.092514
202B:B:C271 3.83415
203B:B:S275 3.9225418
204B:B:V276 1.72667616
205B:B:F278 5.84667617
206B:B:R283 5.75857719
207B:B:L284 3.386515
208B:B:L285 5.1516
209B:B:L286 4.81417
210B:B:A287 2.07516
211B:B:G288 2.7925417
212B:B:Y289 6.41286717
213B:B:D290 6.9825416
214B:B:D291 6.0975418
215B:B:C294 3.03515
216B:B:N295 6.462516
217B:B:W297 6.16571718
218B:B:D298 7.2175419
219B:B:L300 3.98833616
220B:B:K301 5.315405
221B:B:R304 8.3525415
222B:B:V307 3.99413
223B:B:H311 6.55833619
224B:B:R314 12.348518
225B:B:V315 2.81517
226B:B:C317 2.545417
227B:B:L318 3.77833616
228B:B:T321 8.415417
229B:B:D323 6.89417
230B:B:M325 4.792515
231B:B:V327 5.01516
232B:B:W332 11.08819
233B:B:D333 5.7475419
234B:B:L336 3.776517
235B:B:K337 8.125416
236B:B:I338 3.10833615
237B:B:W339 7.19625819
238G:G:R27 4.955408
239G:G:V30 3.0425468
240G:G:Y40 6.5475416
241G:G:D48 6.372519
242G:G:L50 3.428519
243G:G:L51 3.614516
244G:G:N59 6.08619
245G:G:P60 8.1425419
246G:G:F61 4.97778918
247L:L:V21 4.74420
248L:L:Q25 5.85167620
249L:L:S26 3.58400
250L:L:I39 5.075420
251L:L:C41 5.05420
252L:L:Y46 7.57520
253L:L:F48 6.358520
254L:L:Y51 9.5925420
255L:L:Y52 7.934520
256L:L:I53 3.42420
257L:L:W55 5.865820
258L:L:K57 6.272520
259L:L:Q62 3.9775420
260L:L:L64 8.7525420
261L:L:I67 4.395420
262L:L:F69 4.874520
263L:L:N71 6.138520
264L:L:P72 5.632520
265L:L:G73 3.1375420
266L:L:H76 3.9075420
267L:L:N80 3.3425420
268L:L:F83 5.452520
269L:L:A98 2.3375420
270L:L:F99 4.7154150
271L:L:M100 8.3925420
272L:L:L102 3.028520
273L:L:I112 2.7420
274L:L:Y113 5.675620
275L:L:Y114 7.4125420
276L:L:C115 5.182520
277L:L:R117 14.536520
278L:L:L123 3.4375420
279L:L:R124 10.57420
280L:L:I125 4.9425420
281L:L:I126 5.1975420
282L:L:K128 7.8825420
283L:L:F129 5.856520
284L:L:W132 5.45429720
285L:L:V136 4.175400
286L:L:V140 3.76754140
287R:R:P33 9.0925495
288R:R:F35 5.626595
289R:R:H36 11.5675498
290R:R:F38 4.0775425
291R:R:D42 4.7625427
292R:R:E44 4.4975424
293R:R:H46 9.2525424
294R:R:W53 7.85857722
295R:R:M57 3.4425425
296R:R:H60 7.182528
297R:R:N71 5.778509
298R:R:F78 5.695606
299R:R:Y91 6.048527
300R:R:L95 5.18429
301R:R:T98 4.76628
302R:R:V102 4.23426
303R:R:L106 5.7125428
304R:R:R109 7.61526
305R:R:F110 10.01527
306R:R:Y114 7.395422
307R:R:H126 5.445406
308R:R:Y130 5.472526
309R:R:F131 5.06333625
310R:R:L132 4.216505
311R:R:N133 4.846528
312R:R:M134 5.90167627
313R:R:C136 4.305426
314R:R:I138 6.95428
315R:R:F140 6.49857727
316R:R:T142 2.7525408
317R:R:R148 4.898529
318R:R:Y149 8.636508
319R:R:I152 2.57427
320R:R:W175 4.822529
321R:R:T182 2.848526
322R:R:F205 7.388529
323R:R:P208 2.9275409
324R:R:I219 3.61527
325R:R:M220 4.0325424
326R:R:L229 2.2675412
327R:R:R235 6.17833615
328R:R:L243 4.435427
329R:R:F250 6.152529
330R:R:C253 2.6425427
331R:R:F254 4.96857729
332R:R:F257 6.498526
333R:R:H258 7.854528
334R:R:R260 6.33404
335R:R:Q261 4.2275406
336R:R:M270 3.3925163
337R:R:L276 4.3525424
338R:R:Y279 6.16143725
339R:R:H280 6.774525
340R:R:T284 4.41425
341R:R:S287 3.4075427
342R:R:D293 5.555629
343R:R:P294 2.97429
344R:R:Y297 5.77667629
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1M:M:E379 M:M:P381 19.55753.14YesYes000
2M:M:E379 M:M:Q376 18.97185.1YesYes200
3M:M:L291 M:M:Q376 14.52642.66YesYes200
4M:M:L380 M:M:P381 20.97751.64NoYes000
5L:L:I125 R:R:H46 11.236810.61YesYes204
6R:R:H46 R:R:W53 12.420514.81YesYes242
7L:L:N78 M:M:L380 20.905313.73NoNo000
8L:L:F69 L:L:Y66 19.17795.16YesNo000
9L:L:Y66 M:M:Y382 10.042619.86NoYes000
10L:L:F69 L:L:Y52 10.87557.22YesYes200
11L:L:I126 L:L:Y52 13.14.84YesYes200
12L:L:F129 L:L:I126 12.63228.79YesYes200
13L:L:F129 M:M:Y322 13.85153.09YesYes200
14L:L:I125 L:L:Y52 10.80553.63YesYes200
15B:B:G77 B:B:L95 11.93665.13NoYes088
16B:B:G77 B:B:S98 12.08331.86NoNo088
17B:B:S98 B:B:W99 12.2418.65NoYes089
18A:A:G202 A:A:V201 96.71031.84NoYes199
19A:A:G202 A:A:K46 95.79013.49NoYes199
20A:A:G40 A:A:K46 95.29755.23NoYes099
21A:A:C224 A:A:G40 95.33921.96NoNo079
22A:A:C224 A:A:I49 95.38161.64NoNo077
23A:A:F267 A:A:I49 95.74932.51YesNo097
24A:A:F267 A:A:F334 96.49843.22YesYes193
25A:A:F334 A:A:Y320 97.06312.06YesYes137
26A:A:E318 A:A:Y320 49.9915.61NoYes147
27A:A:E318 R:R:R235 50.03098.14NoYes145
28A:A:F354 R:R:R235 1008.55NoYes055
29A:A:F354 A:A:K349 99.97946.2NoNo055
30A:A:K349 R:R:G303 99.95871.74NoNo056
31R:R:F304 R:R:G303 99.9381.51NoNo086
32R:R:F304 R:R:F78 99.89645.36NoYes086
33R:R:C298 R:R:F78 98.32115.59NoYes076
34R:R:C298 R:R:P294 98.19121.88NoYes279
35R:R:D293 R:R:P294 83.5971.61YesYes299
36R:R:D293 R:R:N289 63.541210.77YesNo299
37R:R:F254 R:R:N289 62.73189.67YesNo299
38R:R:F254 R:R:M134 61.89433.73YesYes297
39R:R:M134 R:R:Y130 34.29287.18YesYes276
40R:R:Y130 R:R:Y279 26.65872.98YesYes265
41R:R:L41 R:R:Y279 51.93524.69NoYes255
42R:R:E44 R:R:L41 51.7153.98YesNo245
43L:L:H76 R:R:E44 51.32036.15YesYes204
44L:L:H76 L:L:N78 20.98163.83YesNo200
45A:A:D341 A:A:Y320 50.017910.34NoYes187
46A:A:D341 R:R:R235 49.99753.57NoYes185
47R:R:F257 R:R:M134 27.55837.46YesYes267
48R:R:F257 R:R:Y279 26.87824.13YesYes265
49B:B:C317 B:B:S316 12.61611.72YesNo079
50B:B:S316 B:B:W332 12.70324.94NoYes099
51A:A:W258 B:B:W332 12.59844.69YesYes159
52A:A:I212 A:A:W258 37.95072.35YesYes185
53A:A:I212 A:A:W211 29.58723.52YesYes189
54A:A:V201 A:A:W211 66.45958.58YesYes199
55A:A:L37 A:A:V201 16.09832.98YesYes199
56A:A:I221 A:A:L37 15.22982.85YesYes189
57A:A:I221 A:A:I264 17.62692.94YesYes186
58A:A:W211 B:B:Y145 36.0882.89YesYes198
59B:B:D186 B:B:Y145 24.58145.75YesYes198
60A:A:W258 B:B:R314 24.90374YesYes158
61B:B:L14 G:G:L19 11.7496.92YesNo089
62B:B:L14 G:G:A23 15.89331.58YesNo088
63B:B:I18 G:G:A23 17.27443.25NoNo078
64B:B:Q220 G:G:E22 13.50422.55YesNo079
65G:G:E22 G:G:Q18 13.65577.65NoNo099
66B:B:C218 G:G:Q18 13.96393.05YesNo059
67B:B:D205 B:B:H183 17.81398.82YesYes399
68B:B:D205 B:B:G185 24.31671.68YesNo095
69B:B:D186 B:B:G185 24.47441.68YesNo095
70B:B:I18 G:G:R27 10.49443.76NoYes078
71B:B:H183 B:B:W211 10.25414.23YesYes398
72B:B:D290 B:B:R314 11.194420.25YesYes168
73B:B:S275 B:B:T274 14.50153.2YesNo188
74B:B:R314 B:B:T274 14.30323.88YesNo188
75L:L:F48 L:L:P72 11.909814.45YesYes200
76L:L:N71 L:L:P72 22.69696.52YesYes200
77L:L:N71 L:L:S74 10.73667.45YesNo200
78L:L:S74 R:R:L120 11.00764.5NoNo001
79R:R:F110 R:R:W53 14.188513.03YesYes272
80R:R:F110 R:R:H60 16.266211.31YesYes278
81R:R:H60 R:R:L106 26.659111.57YesYes288
82R:R:G103 R:R:L106 28.03581.71NoYes258
83R:R:G103 R:R:S290 28.05791.86NoNo258
84R:R:D99 R:R:S290 28.720210.31NoNo098
85R:R:D99 R:R:N71 14.457612.12NoYes099
86R:R:N71 R:R:P294 14.68116.52YesYes099
87R:R:D293 R:R:D99 14.42496.65YesNo099
88L:L:F69 L:L:H76 30.01893.39YesYes200
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:N378 R:R:P50 1.63 2 No No 0 5 0 1
M:M:L380 R:R:G47 5.13 0 No No 0 2 0 1
L:L:Y52 R:R:R117 12.35 2 Yes No 0 6 0 1
L:L:N71 R:R:G118 1.7 2 Yes No 0 7 0 1
L:L:S74 R:R:G118 1.86 2 No No 0 7 0 1
L:L:S74 R:R:L120 4.5 2 No No 0 1 0 1
L:L:H76 R:R:R40 2.26 2 Yes No 0 6 0 1
L:L:H76 R:R:E44 6.15 2 Yes Yes 0 4 0 1
L:L:K84 R:R:H272 6.55 0 No No 0 3 0 1
L:L:G120 R:R:R117 4.5 0 No No 0 6 0 1
L:L:F122 R:R:Y114 8.25 0 No Yes 0 2 0 1
L:L:L123 R:R:L54 4.15 2 Yes No 0 5 0 1
L:L:R124 R:R:P50 14.41 2 Yes No 0 5 0 1
L:L:I125 R:R:H46 10.61 2 Yes Yes 0 4 0 1
L:L:I125 R:R:G47 1.76 2 Yes No 0 2 0 1
R:R:H36 R:R:L120 11.57 9 Yes No 8 1 2 1
R:R:A39 R:R:L120 3.15 0 No No 8 1 2 1
R:R:E44 R:R:L41 3.98 2 Yes No 4 5 1 2
R:R:L276 R:R:L41 2.77 2 Yes No 4 5 2 2
R:R:E43 R:R:H46 6.15 0 No Yes 5 4 2 1
R:R:E43 R:R:R117 9.3 0 No No 5 6 2 1
R:R:E44 R:R:L276 6.63 2 Yes Yes 4 4 1 2
R:R:H46 R:R:W53 14.81 2 Yes Yes 4 2 1 2
R:R:H46 R:R:Y114 5.44 2 Yes Yes 4 2 1 1
R:R:L54 R:R:W53 2.28 2 No Yes 5 2 1 2
R:R:M57 R:R:W53 2.33 2 Yes Yes 5 2 2 2
R:R:W53 R:R:Y114 13.5 2 Yes Yes 2 2 2 1
R:R:L54 R:R:M57 2.83 2 No Yes 5 5 1 2
R:R:M57 R:R:Y114 2.39 2 Yes Yes 5 2 2 1
R:R:C119 R:R:G118 1.96 0 No No 3 7 2 1
R:R:H272 R:R:H273 9.55 0 No No 3 3 1 2
L:L:G75 R:R:R40 1.5 0 No No 0 6 0 1
R:R:E44 R:R:H272 1.23 2 Yes No 4 3 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
60.00Single8HS2Fab0468HS2-GPR20-Fab046
27.27Single4BWBNeurotensin4BWB-NTS1-Neurotensin
25.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
23.08Single5T04Neurotensin5T04-NTS1-Neurotensin
23.08Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
22.22Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
20.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
20.00Single6D35Cholesterol6D35-SMO-Cholesterol
20.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
20.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
20.00Single6OS1TRV0266OS1-AT1-TRV026
20.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
20.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
20.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
20.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
20.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
20.00Single7DTTCa7DTT-CaS-Ca-Ca
20.00Single7DTTCa7DTT-CaS-Ca-Ca
20.00Single7DTUTryptophan7DTU-CaS-Tryptophan
20.00Single7DTUTryptophan7DTU-CaS-Tryptophan
20.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
20.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
20.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
20.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
20.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
20.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
20.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
20.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
20.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
20.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
20.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
20.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
20.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
20.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7FIIhCG7FII-LH-hCG-6fuf
20.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
20.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
20.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
20.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
20.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
20.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
20.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
20.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
20.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
20.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
20.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
20.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
20.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
20.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
20.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
20.00Single7XW7K1-707XW7-TSH-K1-70
20.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
20.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
20.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
20.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
20.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
20.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
20.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
20.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
20.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
20.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
20.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
20.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
20.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
20.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
20.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
20.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
20.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
20.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
20.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
20.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
20.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
20.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
20.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
20.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
20.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
20.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
20.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
20.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
20.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
20.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
20.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
20.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
20.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
20.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
20.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
20.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
20.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
20.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
20.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
20.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
20.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
20.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
20.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00Consensusgs_proteinOrthosteric Ligandgs_gphr
20.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
20.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
20.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
20.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
20.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
20.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
20.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
20.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
20.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
20.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
20.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
20.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
20.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
20.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
20.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
19.05Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
18.75Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
18.75Single4XEENeurotensin4XEE-NTS1-Neurotensin
18.75Single4XESNeurotensin4XES-NTS1-Neurotensin
18.75Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
18.75Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single6YVRNTS8-136YVR-NTS1-NTS8-13
18.75Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
18.75Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
18.75Consensusnts_onOrthosteric Ligandnts1_on
18.18Single4O9RCyclopamine4O9R-SMO-Cyclopamine
18.18Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.18Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
18.18Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
18.18Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.65Single4BUONeurotensin4BUO-NTS1-Neurotensin
17.65Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
17.65Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
17.65Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
17.65Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
17.39Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single4QINSAG1.54QIN-SMO-SAG1.5
16.67Single6KNMJN241-96KNM-Apelin-JN241-9
16.67Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
16.67Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
16.67Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
16.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
16.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
16.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
16.67Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
16.67Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
16.67Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
16.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
16.67Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.67Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.67Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
16.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.00Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.79Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
15.79Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
15.79Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.79Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
15.79Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
15.79Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
15.38Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.38Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.38Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
15.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.38Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.38Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
15.38Consensusgi_class-fOrthosteric Ligandgi_frizzled
15.38Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.38Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
15.38Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
15.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
15.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
15.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
14.29Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.29Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
14.29Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
14.29Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
14.29Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
14.29Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
14.29Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
14.29Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.79Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
13.79Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.79Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.79Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.64Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.64Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.64Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
13.64Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
13.64Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
13.64Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.33Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
13.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
13.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
13.33Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
13.04Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.04Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.04Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
13.04Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
13.04Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.04Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
13.04Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
13.04Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
12.50Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
12.50Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
12.50Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
12.50Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
12.50Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
12.50Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
12.50Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
12.50Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
12.50Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
12.50Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
12.50Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
12.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
12.50Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
12.50Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
12.50Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.50Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
12.50Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
12.50Consensuslpa_offOrthosteric Ligandlpa1_off
12.50Consensuslpa_onOrthosteric Ligandlpa1_on
12.50Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.12Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.12Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
12.00Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
12.00Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
11.76Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
11.76Single6OS2TRV0266OS2-AT1-TRV026
11.76Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
11.76Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
11.76Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
11.76Consensuschemokine_offOrthosteric Ligandcxcr_off
11.76Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
11.76Consensuscxcr_offOrthosteric Ligandcxcr4_off
11.76Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.76Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
11.54Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
11.54Single6LMLGlucagon6LML-Glucagon-Glucagon
11.54Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
11.54Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
11.54Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.54Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
11.54Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
11.54Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
11.54Single8IY6Endothelin-18IY6-ETB-Endothelin-1
11.54Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.54Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
11.54Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
11.43Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
11.11Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.11Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
11.11Single5GLHEndothelin-15GLH-ETB-Endothelin-1
11.11Single5L7DCholesterol5L7D-SMO-Cholesterol
11.11Single6IGKEndothelin-36IGK-ETB-Endothelin-3
11.11Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
11.11Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
11.11Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
11.11Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
11.11Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
11.11Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
11.11Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
11.11Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
11.11Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
11.11Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
11.11Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.11Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
11.11Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
11.11Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
11.11Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
10.71Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
10.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
10.71Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
10.71Consensusglp_onOrthosteric Ligandglp1_on glp2_on
10.53Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
10.53Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
10.53Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.53Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
10.53Consensuslpl_offOrthosteric Ligands1p_off lpa_off
10.53Consensuslpl_onOrthosteric Ligands1p_on lpa_on
10.53Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
10.34Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
10.34Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
10.34Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
10.34Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
10.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
10.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
10.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
10.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
9.52Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
9.52Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
9.52Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
9.52Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
9.52Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
9.52Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
9.52Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
9.38Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
9.09Single3OE0CVX153OE0-CXCR4-CVX15
9.09Single4XNWMRS25004XNW-P2Y1-MRS2500
9.09Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.09Single6LI0GTPL98046LI0-GPR52-GTPL9804
9.09Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
9.09Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
9.09Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
9.09Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
9.09Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
9.09Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
9.09Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
9.09Consensusangiotensin_onOrthosteric Ligandat1_on
9.09Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
9.09Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
9.09Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
9.09Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
9.09Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
9.09Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
9.09Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
9.09Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
8.82Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
8.70Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
8.70Single6JODAngiotensin II6JOD-AT2-Angiotensin II
8.70Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
8.70Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
8.70Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
8.70Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
8.70Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
8.70Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
8.70Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
8.70Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
8.57Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
8.57Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
8.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
8.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7UL2SR486927UL2-NTS1-SR48692-Na
8.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
8.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
8.33Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
8.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
8.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
8.33Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
8.33Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.33Consensusgo_proteinOrthosteric Ligandgo_chemokine
8.33Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
8.33Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
8.00Single4XT3Fractalkine4XT3-US28-Fractalkine
8.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
8.00Single6FJ3PTH6FJ3-PTH1-PTH
8.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.00Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
8.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
8.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Single7SK3CXCL127SK3-ACKR3-CXCL12
8.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
8.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
8.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
8.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.69Single5U09Taranabant5U09-CB1-Taranabant
7.69Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
7.69Single7BR3Elagolix7BR3-GnRH1-Elagolix
7.69Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
7.69Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
7.69Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
7.69Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
7.69Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
7.69Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
7.69Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
7.69Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
7.69Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
7.69Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
7.69Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
7.69Consensusclass-f_offOrthosteric Ligandsmo_off
7.69Consensusendothelin_onOrthosteric Ligandetb_on eta_on
7.69Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
7.69Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
7.69Consensusgo_class-b1Orthosteric Ligandgo_crf
7.69Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
7.69Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
7.41Single6IGLIRL16206IGL-ETB-IRL1620
7.41Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.41Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
7.41Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
7.41Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
7.41Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
7.41Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
7.41Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
7.14Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
7.14Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
7.14Single6ZINSR486926ZIN-NTS1-SR48692
7.14Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
7.14Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
7.14Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
7.14Single7VV6C48/807VV6-MRGPRX2-C48/80
7.14Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
7.14Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
7.14Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
7.14Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
7.14Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
7.14Consensusgnrh_offOrthosteric Ligandgnrh1_off
7.14Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
7.14Consensuss1p_offOrthosteric Ligands1p1_off
6.90Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.90Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
6.90Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
6.90Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
6.67Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
6.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
6.67Single5TGZAM65385TGZ-CB1-AM6538
6.67Single6D27CAY104716D27-DP2-CAY10471
6.67Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
6.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.67Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
6.67Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
6.67Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
6.67Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
6.67Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
6.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
6.67Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
6.67Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
6.67Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
6.67Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8K5DGSK2560738K5D-HCA2-GSK256073
6.67Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.67Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
6.67Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
6.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
6.67Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
6.67Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
6.45Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
6.45Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
6.45Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
6.45Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
6.45Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
6.45Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
6.45Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
6.25Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
6.25Single5C1MBU725C1M-μ-BU72
6.25Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
6.25Single6Z4SSR486926Z4S-NTS1-SR48692
6.25Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
6.25Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
6.25Single7C4SS1P7C4S-S1P3-S1P
6.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
6.25Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
6.25Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
6.25Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
6.25Single7YXAONO-54306087YXA-S1P5-ONO-5430608
6.25Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
6.25Consensuspth_onOrthosteric Ligandpth1_on pth2_on
6.25Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.88Single5V56TC1145V56-SMO-TC114
5.88Single5V57TC1145V57-SMO-TC114
5.88Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.88Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.88Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
5.88Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
5.88Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
5.88Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
5.88Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
5.88Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
5.88Single8E0GBU728E0G-μ-BU72
5.88Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
5.88Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.88Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
5.88Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
5.88Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
5.88Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
5.88Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
5.88Consensuschemerin_onOrthosteric Ligandcml1_on
5.88Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
5.88Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
5.88Consensusrelaxin_onOrthosteric Ligandrxfp4_on
5.88Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
5.88Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
5.56Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
5.56Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
5.56Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
5.56Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.56Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
5.56Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.56Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
5.56Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
5.56Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
5.56Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
5.56Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
5.56Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
5.56Consensusdp_offOrthosteric Liganddp2_off
5.56Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
5.56Consensusgs_steroidOrthosteric Ligandgs_bileacid
5.56Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.56Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
5.56Consensusnts_offOrthosteric Ligandnts1_off
5.56Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
5.56Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.26Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
5.26Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
5.26Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
5.26Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
5.26Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
5.26Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
5.26Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
5.26Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
5.26Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
5.26Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
5.26Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
5.26Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.26Consensusorexin_onOrthosteric Ligandox2_on
5.26Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.26Consensussteroid_onOrthosteric Ligandbileacid_on
5.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
5.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
5.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
5.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
5.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
5.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.00Single7SK9CCX6627SK9-ACKR3-CCX662
5.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
5.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
5.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
5.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
5.00Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.76Single4XT1Fractalkine4XT1-US28-Fractalkine
4.76Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
4.76Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
4.76Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
4.76Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
4.76Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
4.76Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
4.76Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
4.76Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
4.76Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.76Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.76Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
4.76Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
4.76Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.55Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
4.55Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
4.55Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.55Single7SK5CXCL127SK5-ACKR3-CXCL12
4.55Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
4.55Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
4.55Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.55Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
4.55Consensussst_offOrthosteric Ligandsst2_off
4.55Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
4.35Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.35Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single7XNACYN1548067XNA-SST2-CYN154806
4.35Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.35Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
4.35Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
4.35Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
4.35Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
4.17Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.17Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.17Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
4.17Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.17Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
4.17Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.17Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.17Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
4.17Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
4.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
4.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.85Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.85Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
3.85Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
3.85Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.70Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
3.70Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
3.70Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.70Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
3.57Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
3.45Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.45Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.33Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.12Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.63Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1

PDB Summary
PDB 8HSC
Class A
SubFamily Orphan
Type A orphans
SubType GPR20
Species Homo sapiens
Ligand Fab046
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.22
Date 2023-03-08 
D.O.I. 10.1038/s41421-023-00520-8
Net Summary
Imin 1.58
Number of Linked Nodes 1005
Number of Links 1509
Number of Hubs 344
Number of Links mediated by Hubs 1146
Number of Communities 16
Number of Nodes involved in Communities 488
Number of Links involved in Communities 863
Path Summary
Number Of Nodes in MetaPath 89
Number Of Links MetaPath 88
Number of Shortest Paths 7104967
Length Of Smallest Path 3
Average Path Length 37.8433
Length of Longest Path 66
Minimum Path Strength 1.225
Average Path Strength 4.80211
Maximum Path Strength 25.44
Minimum Path Correlation 0.7
Average Path Correlation 0.998142
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 42.4306
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 61.8626
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8HSC_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKN 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HSC_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HSC_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99678
Sequence
>8HSC_Chain_R
VPLFHLFAR LDEELHGTF PGLWLALMA VHGAIFLAG LVLNGLALY 
VFCCRTRAK TPSVIYTIN LVVTDLLVG LSLPTRFAV YYGARGCLR 
CAFPHVLGY FLNMHCSIL FLTCICVDR YLAIVRPEG SRRCRQPAC 
ARAVCAFVW LAAGAVTLS VLGVRVFAL TVLEFLLPL LVISVFTGR 
IMCALSRPG LLHQGRQRR VRAMQLLLT VLIIFLVCF TPFHARQVA 
VALWPDMPH HTSLVVYHV AVTLSSLNS CMDPIVYCF VTSGFQATV 
RGL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HS2AOrphanA orphansGPR20Homo sapiensFab046--3.082023-03-0810.1038/s41421-023-00520-8
8HS3AOrphanA orphansGPR20Homo sapiens--Gi1/&β;1/&γ;23.142023-03-0810.1038/s41421-023-00520-8
8HSCAOrphanA orphansGPR20Homo sapiensFab046-Gi1/&β;1/&γ;23.222023-03-0810.1038/s41421-023-00520-8




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