psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q20	L:L:Q22	8.96	No	No	0	0	0
2	L:L:G45	L:L:V21	3.68	No	Yes	0	0	0
3	L:L:V21	L:L:Y46	6.31	Yes	Yes	3	0	0
4	L:L:R117	L:L:V21	3.92	Yes	Yes	3	0	0
5	L:L:V21	L:L:Y131	5.05	Yes	No	3	0	0
6	L:L:Q134	L:L:Q24	11.52	No	No	0	0	0
7	L:L:C41	L:L:Q25	4.58	No	Yes	0	0	0
8	L:L:G133	L:L:Q25	6.58	No	Yes	0	0	0
9	L:L:Q134	L:L:Q25	10.24	No	Yes	0	0	0
10	L:L:G135	L:L:Q25	4.93	No	Yes	0	0	0
11	L:L:Q25	L:L:V136	5.73	Yes	Yes	0	0	0
12	L:L:G27	L:L:S26	3.71	No	Yes	0	0	0
13	L:L:E29	L:L:S26	5.75	No	Yes	0	0	0
14	L:L:A31	L:L:V140	5.09	No	No	0	0	0
15	L:L:P33	L:L:V140	3.53	No	No	0	0	0
16	L:L:K38	L:L:S36	6.12	No	No	0	0	0
17	L:L:L105	L:L:V37	5.96	No	No	0	0	0
18	L:L:F99	L:L:K38	8.69	No	No	0	0	0
19	L:L:K38	L:L:Q101	12.2	No	No	0	0	0
20	L:L:I39	L:L:W55	4.7	Yes	Yes	4	0	0
21	L:L:I39	L:L:M100	5.83	Yes	Yes	4	0	0
22	L:L:I39	L:L:Y113	3.63	Yes	Yes	4	0	0
23	L:L:I39	L:L:V136	6.14	Yes	Yes	0	0	0
24	L:L:C41	L:L:W55	6.53	No	Yes	4	0	0
25	L:L:C115	L:L:C41	7.28	No	No	4	0	0
26	L:L:A43	L:L:Y46	4	No	Yes	3	0	0
27	L:L:A43	L:L:F48	4.16	No	Yes	3	0	0
28	L:L:G45	L:L:S44	3.71	No	No	0	0	0
29	L:L:F48	L:L:Y46	4.13	Yes	Yes	3	0	0
30	L:L:Y46	L:L:Y51	6.95	Yes	Yes	3	0	0
31	L:L:R117	L:L:Y46	16.46	Yes	Yes	3	0	0
32	L:L:S50	L:L:T47	6.4	No	No	0	0	0
33	L:L:F48	L:L:I53	3.77	Yes	No	0	0	0
34	L:L:F48	L:L:P72	14.45	Yes	No	0	0	0
35	L:L:F48	L:L:S96	5.28	Yes	No	0	0	0
36	L:L:G73	L:L:T49	3.64	No	No	0	0	0
37	L:L:S50	L:L:Y51	5.09	No	Yes	0	0	0
38	L:L:R117	L:L:Y51	23.66	Yes	Yes	3	0	0
39	L:L:F69	L:L:Y52	7.22	Yes	Yes	1	0	0
40	L:L:N71	L:L:Y52	11.63	Yes	Yes	0	0	0
41	L:L:I125	L:L:Y52	3.63	No	Yes	1	0	0
42	L:L:I126	L:L:Y52	4.84	Yes	Yes	1	0	0
43	L:L:Y52	R:R:R117	12.35	Yes	No	0	0	6
44	L:L:L89	L:L:W55	4.56	No	Yes	0	0	0
45	L:L:M100	L:L:W55	15.12	Yes	Yes	4	0	0
46	L:L:C115	L:L:W55	9.14	No	Yes	4	0	0
47	L:L:F83	L:L:K57	4.96	Yes	Yes	0	0	0
48	L:L:D109	L:L:K57	5.53	No	Yes	0	0	0
49	L:L:A111	L:L:K57	4.82	No	Yes	0	0	0
50	L:L:K57	L:L:Y113	13.14	Yes	Yes	0	0	0
51	L:L:L64	L:L:Q58	14.64	No	No	0	0	0
52	L:L:Q62	L:L:T59	9.92	No	No	0	0	0
53	L:L:G61	L:L:T60	3.64	No	No	0	0	0
54	L:L:L64	N:N:Y373	4.69	No	Yes	0	0	0
55	L:L:L64	N:N:F384	13.4	No	Yes	0	0	0
56	L:L:G68	L:L:Y66	7.24	No	No	0	0	0
57	L:L:F69	L:L:Y66	5.16	Yes	No	0	0	0
58	L:L:Y66	N:N:Y382	19.86	No	Yes	0	0	0
59	L:L:G68	L:L:I67	3.53	No	No	0	0	0
60	L:L:F83	L:L:I67	8.79	Yes	No	0	0	0
61	L:L:F69	L:L:N78	4.83	Yes	No	0	0	0
62	L:L:F69	L:L:I125	3.77	Yes	No	1	0	0
63	L:L:I70	L:L:T77	7.6	No	No	0	0	0
64	L:L:I70	L:L:L89	5.71	No	No	0	0	0
65	L:L:I70	L:L:V91	6.14	No	No	0	0	0
66	L:L:N71	L:L:P72	6.52	Yes	No	0	0	0
67	L:L:N71	L:L:S74	7.45	Yes	Yes	0	0	0
68	L:L:S74	R:R:Y113	5.09	Yes	Yes	0	0	6
69	L:L:S74	R:R:L120	4.5	Yes	No	0	0	1
70	L:L:H76	L:L:N78	3.83	No	No	0	0	0
71	L:L:H76	R:R:E44	6.15	No	Yes	0	0	4
72	L:L:T77	L:L:Y79	11.24	No	No	0	0	0
73	L:L:N78	N:N:L380	13.73	No	No	0	0	0
74	L:L:L89	L:L:Y79	5.86	No	No	0	0	0
75	L:L:K82	L:L:N80	5.6	No	No	11	0	0
76	L:L:F83	L:L:N80	4.83	Yes	No	11	0	0
77	L:L:F83	L:L:K82	6.2	Yes	No	11	0	0
78	L:L:K84	R:R:H272	6.55	No	No	0	0	3
79	L:L:K86	L:L:S104	6.12	No	No	0	0	0
80	L:L:F99	L:L:T90	5.19	No	No	0	0	0
81	L:L:D92	L:L:S95	4.42	No	No	12	0	0
82	L:L:D92	L:L:T97	13.01	No	No	12	0	0
83	L:L:S95	L:L:T97	4.8	No	No	12	0	0
84	L:L:L102	L:L:M100	4.24	Yes	Yes	4	0	0
85	L:L:M100	L:L:Y113	8.38	Yes	Yes	4	0	0
86	L:L:L102	L:L:Y113	3.52	Yes	Yes	4	0	0
87	L:L:D108	L:L:T106	11.56	No	No	0	0	0
88	L:L:D109	L:L:T106	7.23	No	No	0	0	0
89	L:L:S110	L:L:V140	4.85	No	No	0	0	0
90	L:L:I112	L:L:Y114	4.84	No	Yes	0	0	0
91	L:L:W132	L:L:Y114	7.72	Yes	Yes	2	0	0
92	L:L:G135	L:L:Y114	10.14	No	Yes	0	0	0
93	L:L:Y114	N:N:P330	6.95	Yes	No	2	0	0
94	L:L:A116	L:L:W132	5.19	No	Yes	0	0	0
95	L:L:D130	L:L:R117	21.44	No	Yes	3	0	0
96	L:L:R117	L:L:Y131	7.2	Yes	No	3	0	0
97	L:L:G118	L:L:I126	3.53	No	Yes	0	0	0
98	L:L:G120	R:R:R117	4.5	No	No	0	0	6
99	L:L:G121	L:L:T127	3.64	No	No	0	0	0
100	L:L:F122	R:R:Y114	8.25	No	No	0	0	2
101	L:L:L123	L:L:R124	3.64	No	Yes	7	0	0
102	L:L:L123	N:N:Y318	3.52	No	Yes	7	0	0
103	L:L:L123	R:R:L54	4.15	No	No	0	0	5
104	L:L:R124	N:N:Y318	13.38	Yes	Yes	7	0	0
105	L:L:R124	N:N:N378	10.85	Yes	No	7	0	0
106	L:L:R124	R:R:P50	14.41	Yes	No	0	0	5
107	L:L:I125	R:R:H46	10.61	No	Yes	1	0	4
108	L:L:F129	L:L:I126	8.79	No	Yes	1	0	0
109	L:L:I126	N:N:Y382	3.63	Yes	Yes	1	0	0
110	L:L:D130	L:L:K128	8.3	No	No	0	0	0
111	L:L:K128	N:N:Y335	17.91	No	No	0	0	0
112	L:L:F129	N:N:Q375	8.2	No	Yes	0	0	0
113	L:L:F129	N:N:Y382	6.19	No	Yes	1	0	0
114	L:L:D130	L:L:Y131	14.94	No	No	3	0	0
115	L:L:W132	N:N:Y322	8.68	Yes	No	0	0	0
116	L:L:W132	N:N:P330	8.11	Yes	No	2	0	0
117	L:L:W132	N:N:F384	4.01	Yes	Yes	0	0	0
118	N:N:K313	N:N:T289	6.01	No	Yes	8	0	0
119	N:N:Q376	N:N:T289	14.17	No	Yes	8	0	0
120	N:N:E379	N:N:T289	5.64	Yes	Yes	8	0	0
121	N:N:C309	N:N:L291	4.76	No	No	2	0	0
122	N:N:C374	N:N:L291	6.35	Yes	No	2	0	0
123	N:N:R310	N:N:T292	3.88	No	No	0	0	0
124	N:N:Q293	N:N:Y373	5.64	Yes	Yes	2	0	0
125	N:N:C374	N:N:Q293	4.58	Yes	Yes	2	0	0
126	N:N:G385	N:N:Q293	6.58	No	Yes	0	0	0
127	N:N:G387	N:N:Q293	6.58	No	Yes	2	0	0
128	N:N:I307	N:N:S294	6.19	Yes	No	0	0	0
129	N:N:A298	N:N:E391	4.53	No	No	0	0	0
130	N:N:V299	N:N:V364	8.02	No	No	0	0	0
131	N:N:L390	N:N:V299	4.47	No	No	0	0	0
132	N:N:R304	N:N:T360	3.88	No	No	0	0	0
133	N:N:D362	N:N:R304	8.34	No	No	0	0	0
134	N:N:I361	N:N:V305	4.61	No	No	0	0	0
135	N:N:T306	N:N:T360	7.85	No	No	0	0	0
136	N:N:I307	N:N:T388	10.64	Yes	No	0	0	0
137	N:N:D356	N:N:S308	5.89	No	No	0	0	0
138	N:N:C309	N:N:C374	7.28	No	Yes	2	0	0
139	N:N:D356	N:N:R310	22.63	No	No	0	0	0
140	N:N:E379	N:N:K313	6.75	Yes	No	8	0	0
141	N:N:I319	N:N:V315	7.68	No	No	0	0	0
142	N:N:S316	N:N:T317	4.8	No	No	0	0	0
143	N:N:S316	N:N:Y318	5.09	No	Yes	0	0	0
144	N:N:N378	N:N:Y318	9.3	No	Yes	7	0	0
145	N:N:F357	N:N:I319	10.05	No	No	0	0	0
146	N:N:H320	N:N:Q375	7.42	No	Yes	0	0	0
147	N:N:H320	N:N:I377	3.98	No	No	0	0	0
148	N:N:L359	N:N:W321	18.22	No	No	0	0	0
149	N:N:C374	N:N:W321	5.22	Yes	No	0	0	0
150	N:N:Q375	N:N:Y322	13.53	Yes	No	0	0	0
151	N:N:Q323	N:N:R325	8.18	Yes	No	0	0	0
152	N:N:K331	N:N:Q323	4.07	No	Yes	0	0	0
153	N:N:L333	N:N:Q323	6.65	No	Yes	13	0	0
154	N:N:Q323	N:N:Y372	5.64	Yes	Yes	13	0	0
155	N:N:P330	N:N:Q324	6.32	No	No	2	0	0
156	N:N:N371	N:N:Q324	6.6	No	No	2	0	0
157	N:N:Q324	N:N:Y373	4.51	No	Yes	2	0	0
158	N:N:Q328	N:N:R325	21.03	No	No	0	0	0
159	N:N:K331	N:N:Q329	10.85	No	No	0	0	0
160	N:N:E341	N:N:L332	14.58	No	No	0	0	0
161	N:N:F348	N:N:L333	3.65	Yes	No	0	0	0
162	N:N:L333	N:N:Y372	4.69	No	Yes	13	0	0
163	N:N:N339	N:N:Y335	12.79	No	No	0	0	0
164	N:N:E341	N:N:Y335	4.49	No	No	0	0	0
165	N:N:N339	N:N:S336	4.47	No	No	0	0	0
166	N:N:L340	N:N:V344	4.47	Yes	No	0	0	0
167	N:N:E341	N:N:S342	8.62	No	No	0	0	0
168	N:N:F348	N:N:V344	3.93	Yes	No	0	0	0
169	N:N:F348	N:N:P345	4.33	Yes	No	0	0	0
170	N:N:P363	N:N:R347	7.21	No	No	0	0	0
171	N:N:F348	N:N:I361	5.02	Yes	No	0	0	0
172	N:N:S351	N:N:T358	4.8	No	No	0	0	0
173	N:N:L359	N:N:Y372	3.52	No	Yes	0	0	0
174	N:N:D368	N:N:I361	5.6	No	No	0	0	0
175	N:N:D362	N:N:P363	11.27	No	No	0	0	0
176	N:N:E365	N:N:P366	4.72	No	No	0	0	0
177	N:N:D368	N:N:Y372	9.2	No	Yes	0	0	0
178	N:N:A370	N:N:Y372	4	No	Yes	0	0	0
179	N:N:N371	N:N:Y373	8.14	No	Yes	2	0	0
180	N:N:K389	N:N:N371	4.2	No	No	0	0	0
181	N:N:G387	N:N:Y373	4.35	No	Yes	2	0	0
182	N:N:F384	N:N:Q375	5.86	Yes	Yes	0	0	0
183	N:N:E379	N:N:Q376	5.1	Yes	No	8	0	0
184	N:N:I377	N:N:Y382	4.84	No	Yes	0	0	0
185	N:N:L380	R:R:G47	5.13	No	No	0	0	2
186	R:R:P33	R:R:V32	3.53	No	No	0	5	6
187	R:R:H36	R:R:P33	22.88	Yes	No	0	8	5
188	R:R:P33	R:R:V188	7.07	No	No	0	5	4
189	R:R:L34	R:R:V197	4.47	No	No	0	4	5
190	R:R:F35	R:R:H36	9.05	Yes	Yes	14	5	8
191	R:R:F35	R:R:R121	5.34	Yes	No	14	5	4
192	R:R:F124	R:R:F35	7.5	No	Yes	0	4	5
193	R:R:F35	R:R:V127	6.55	Yes	No	0	5	4
194	R:R:H36	R:R:L120	11.57	Yes	No	0	8	1
195	R:R:H36	R:R:R121	11.28	Yes	No	14	8	4
196	R:R:F38	R:R:Y130	5.16	No	Yes	0	5	6
197	R:R:F38	R:R:Y279	6.19	No	Yes	0	5	5
198	R:R:A39	R:R:Y113	4	No	Yes	0	8	6
199	R:R:E44	R:R:L41	3.98	Yes	No	0	4	5
200	R:R:L41	R:R:Y279	4.69	No	Yes	0	5	5
201	R:R:D42	R:R:R109	11.91	No	No	0	7	6
202	R:R:D42	R:R:Y113	8.05	No	Yes	0	7	6
203	R:R:E43	R:R:H46	6.15	No	Yes	0	5	4
204	R:R:E43	R:R:Y113	12.35	No	Yes	0	5	6
205	R:R:E43	R:R:R117	9.3	No	No	0	5	6
206	R:R:E44	R:R:L276	6.63	Yes	No	0	4	4
207	R:R:L45	R:R:W53	6.83	No	Yes	1	4	2
208	R:R:L276	R:R:L45	4.15	No	No	1	4	4
209	R:R:H280	R:R:L45	15.43	No	No	1	5	4
210	R:R:H46	R:R:W53	14.81	Yes	Yes	1	4	2
211	R:R:H46	R:R:Y114	5.44	Yes	No	1	4	2
212	R:R:F49	R:R:T48	6.49	No	No	0	3	2
213	R:R:L52	R:R:L56	4.15	No	No	0	3	6
214	R:R:F110	R:R:W53	13.03	Yes	Yes	0	7	2
215	R:R:W53	R:R:Y114	13.5	Yes	No	1	2	2
216	R:R:L56	R:R:T284	4.42	No	Yes	0	6	5
217	R:R:F110	R:R:M57	6.22	Yes	No	0	7	5
218	R:R:H60	R:R:L106	11.57	No	No	0	8	8
219	R:R:F110	R:R:H60	11.31	Yes	No	0	7	8
220	R:R:H60	R:R:T284	6.85	No	Yes	0	8	5
221	R:R:I63	R:R:S287	4.64	No	No	0	7	7
222	R:R:F64	R:R:P107	15.89	Yes	No	0	7	9
223	R:R:N71	R:R:V96	4.43	Yes	No	0	9	8
224	R:R:D99	R:R:N71	12.12	No	Yes	0	9	9
225	R:R:L100	R:R:N71	4.12	No	Yes	0	5	9
226	R:R:N71	R:R:P294	6.52	Yes	No	0	9	9
227	R:R:A74	R:R:C298	3.61	No	No	0	8	7
228	R:R:R81	R:R:V77	14.38	No	No	0	6	6
229	R:R:V308	R:R:V77	4.81	No	No	0	4	6
230	R:R:F78	R:R:V89	6.55	Yes	No	0	6	7
231	R:R:F78	R:R:T92	9.08	Yes	No	0	6	8
232	R:R:F78	R:R:I93	6.28	Yes	No	0	6	5
233	R:R:C298	R:R:F78	5.59	No	Yes	0	7	6
234	R:R:F304	R:R:F78	5.36	Yes	Yes	0	8	6
235	R:R:R81	R:R:T307	5.17	No	No	0	6	5
236	R:R:L311	R:R:R81	3.64	No	No	0	4	6
237	R:R:F304	R:R:T82	10.38	Yes	No	0	8	5
238	R:R:P87	R:R:T86	5.25	No	No	0	6	7
239	R:R:D147	R:R:P87	4.83	Yes	No	6	8	6
240	R:R:P87	R:R:R159	8.65	No	Yes	6	6	5
241	R:R:D147	R:R:S88	5.89	Yes	No	0	8	7
242	R:R:I90	R:R:R168	8.77	No	No	0	7	4
243	R:R:C143	R:R:Y91	9.41	No	Yes	0	6	7
244	R:R:I144	R:R:Y91	4.84	No	Yes	0	8	7
245	R:R:D147	R:R:Y91	5.75	Yes	Yes	0	8	7
246	R:R:V170	R:R:Y91	7.57	No	Yes	0	5	7
247	R:R:F140	R:R:N94	12.08	Yes	No	0	7	9
248	R:R:C171	R:R:N94	9.45	No	No	0	7	9
249	R:R:F140	R:R:L95	6.09	Yes	No	0	7	9
250	R:R:L141	R:R:L95	4.15	No	No	0	8	9
251	R:R:D293	R:R:L95	8.14	No	No	0	9	9
252	R:R:L132	R:R:T98	7.37	Yes	Yes	0	5	8
253	R:R:S137	R:R:T98	4.8	No	Yes	0	9	8
254	R:R:F140	R:R:T98	7.78	Yes	Yes	10	7	8
255	R:R:T98	R:R:W175	3.64	Yes	Yes	10	8	9
256	R:R:D99	R:R:S290	10.31	No	No	0	9	8
257	R:R:D293	R:R:D99	6.65	No	No	0	9	9
258	R:R:L101	R:R:L132	4.15	No	Yes	0	7	5
259	R:R:N133	R:R:V102	8.87	No	No	0	8	6
260	R:R:L106	R:R:P107	6.57	No	No	0	8	9
261	R:R:F110	R:R:R109	17.1	Yes	No	0	7	6
262	R:R:H126	R:R:Y113	5.44	No	Yes	0	6	6
263	R:R:C119	R:R:C122	7.28	No	No	0	3	9
264	R:R:A123	R:R:H126	4.39	No	No	0	6	6
265	R:R:F124	R:R:L128	6.09	No	No	0	4	5
266	R:R:H126	R:R:V127	11.07	No	No	0	6	4
267	R:R:F131	R:R:L128	3.65	Yes	No	0	5	5
268	R:R:M134	R:R:Y130	7.18	Yes	Yes	9	7	6
269	R:R:F257	R:R:Y130	8.25	Yes	Yes	9	6	6
270	R:R:V283	R:R:Y130	3.79	No	Yes	0	5	6
271	R:R:F131	R:R:L132	4.87	Yes	Yes	0	5	5
272	R:R:F131	R:R:W175	4.01	Yes	Yes	0	5	9
273	R:R:A178	R:R:F131	5.55	No	Yes	0	7	5
274	R:R:F131	R:R:G179	4.52	Yes	No	0	5	3
275	R:R:F131	R:R:T182	7.78	Yes	No	0	5	6
276	R:R:F254	R:R:N133	3.62	Yes	No	0	9	8
277	R:R:N133	R:R:S286	5.96	No	No	0	8	8
278	R:R:F254	R:R:M134	3.73	Yes	Yes	0	9	7
279	R:R:F257	R:R:M134	7.46	Yes	Yes	9	6	7
280	R:R:H258	R:R:M134	6.57	Yes	Yes	9	8	7
281	R:R:M134	R:R:S286	7.67	Yes	No	0	7	8
282	R:R:H135	R:R:T182	6.85	Yes	No	0	8	6
283	R:R:H135	R:R:L200	9	Yes	No	16	8	5
284	R:R:E204	R:R:H135	11.08	No	Yes	16	5	8
285	R:R:C136	R:R:F140	4.19	No	Yes	10	6	7
286	R:R:C136	R:R:W175	7.84	No	Yes	10	6	9
287	R:R:E204	R:R:I138	6.83	No	Yes	0	5	8
288	R:R:F250	R:R:I138	8.79	No	Yes	0	9	8
289	R:R:F254	R:R:I138	8.79	Yes	Yes	0	9	8
290	R:R:L139	R:R:V174	11.92	No	No	0	5	7
291	R:R:F140	R:R:V174	6.55	Yes	No	0	7	7
292	R:R:F140	R:R:W175	6.01	Yes	Yes	10	7	9
293	R:R:L141	R:R:Y297	7.03	No	Yes	0	8	9
294	R:R:I212	R:R:T142	6.08	No	No	0	7	8
295	R:R:I144	R:R:R148	3.76	No	No	15	8	9
296	R:R:I144	R:R:Y297	6.04	No	Yes	15	8	9
297	R:R:F215	R:R:V146	5.24	No	No	0	7	6
298	R:R:D147	R:R:R159	7.15	Yes	Yes	6	8	5
299	R:R:L243	R:R:R148	3.64	No	No	0	7	9
300	R:R:R148	R:R:Y297	8.23	No	Yes	15	9	9
301	R:R:V153	R:R:Y149	6.31	No	Yes	5	7	8
302	R:R:P155	R:R:Y149	18.08	No	Yes	5	8	8
303	R:R:F215	R:R:Y149	14.44	No	Yes	0	7	8
304	R:R:R218	R:R:Y149	16.46	No	Yes	0	4	8
305	R:R:I219	R:R:Y149	3.63	Yes	Yes	5	7	8
306	R:R:E156	R:R:L150	14.58	No	No	6	5	6
307	R:R:L150	R:R:R159	4.86	No	Yes	6	6	5
308	R:R:L150	R:R:R160	3.64	No	No	6	6	4
309	R:R:P155	R:R:V153	8.84	No	No	5	8	7
310	R:R:E156	R:R:R160	16.28	No	No	6	5	4
311	R:R:C166	R:R:R160	4.18	No	No	0	3	4
312	R:R:L200	R:R:V185	7.45	No	No	0	5	4
313	R:R:E204	R:R:L200	3.98	No	No	16	5	5
314	R:R:H258	R:R:T201	4.11	Yes	No	0	8	5
315	R:R:F205	R:R:L206	3.65	Yes	No	0	9	4
316	R:R:F205	R:R:F250	6.43	Yes	No	0	9	9
317	R:R:F205	R:R:T255	5.19	Yes	No	0	9	5
318	R:R:F205	R:R:H258	19.23	Yes	Yes	0	9	8
319	R:R:L207	R:R:P208	4.93	No	No	0	6	9
320	R:R:F250	R:R:L209	10.96	No	No	0	9	6
321	R:R:L209	R:R:L251	5.54	No	No	0	6	5
322	R:R:L247	R:R:S213	4.5	No	No	0	7	4
323	R:R:I219	R:R:L243	5.71	Yes	No	0	7	7
324	R:R:M220	R:R:M240	7.22	No	No	0	4	4
325	R:R:L243	R:R:M220	4.24	No	No	0	7	4
326	R:R:L228	R:R:R225	6.07	No	No	0	4	4
327	R:R:L228	R:R:R236	9.72	No	No	0	4	6
328	R:R:H230	R:R:R233	5.64	No	No	0	4	3
329	R:R:G232	R:R:R235	4.5	No	No	0	3	5
330	R:R:R233	R:R:R236	6.4	No	No	0	3	6
331	R:R:L242	R:R:V300	5.96	No	No	0	7	6
332	R:R:V246	R:R:Y297	7.57	No	Yes	0	8	9
333	R:R:C253	R:R:F254	4.19	No	Yes	0	7	9
334	R:R:F254	R:R:N289	9.67	Yes	No	0	9	9
335	R:R:P256	R:R:T255	5.25	No	No	0	9	5
336	R:R:F257	R:R:H258	6.79	Yes	Yes	9	6	8
337	R:R:F257	R:R:Q261	5.86	Yes	No	0	6	6
338	R:R:F257	R:R:Y279	4.13	Yes	Yes	0	6	5
339	R:R:Q261	R:R:R260	5.84	No	Yes	0	6	4
340	R:R:R260	R:R:S275	5.27	Yes	No	0	4	4
341	R:R:R260	R:R:V278	3.92	Yes	No	0	4	4
342	R:R:R260	R:R:Y279	10.29	Yes	Yes	0	4	5
343	R:R:D269	R:R:W267	10.05	No	Yes	0	1	2
344	R:R:M270	R:R:W267	4.65	Yes	Yes	0	3	2
345	R:R:M270	R:R:T274	4.52	Yes	No	0	3	2
346	R:R:P271	R:R:T274	8.74	No	No	0	2	2
347	R:R:H272	R:R:H273	9.55	No	No	0	3	3
348	R:R:H280	R:R:L276	3.86	No	No	1	5	4
349	R:R:H280	R:R:Y279	9.8	No	Yes	0	5	5
350	R:R:V283	R:R:Y279	5.05	No	Yes	0	5	5
351	R:R:D293	R:R:N289	10.77	No	No	0	9	9
352	L:L:P107	L:L:T106	3.5	No	No	0	0	0
353	R:R:Q305	R:R:R309	3.5	No	No	0	8	5
354	L:L:G73	L:L:K93	3.49	No	No	0	0	0
355	N:N:G302	N:N:L301	3.42	No	No	0	0	0
356	L:L:G73	L:L:N71	3.39	No	Yes	0	0	0
357	R:R:I138	R:R:P208	3.39	Yes	No	0	8	9
358	R:R:A222	R:R:V153	3.39	No	No	0	5	7
359	N:N:S294	N:N:S308	3.26	No	No	0	0	0
360	L:L:A98	L:L:I53	3.25	No	No	0	0	0
361	R:R:C291	R:R:M292	3.24	No	No	0	6	7
362	L:L:S26	L:L:V136	3.23	Yes	Yes	0	0	0
363	N:N:D288	N:N:P381	3.22	No	No	0	0	0
364	N:N:V299	N:N:V305	3.21	No	No	0	0	0
365	N:N:S308	N:N:T358	3.2	No	No	0	0	0
366	N:N:S353	N:N:T317	3.2	No	No	0	0	0
367	R:R:S287	R:R:T284	3.2	No	Yes	0	7	5
368	L:L:C115	L:L:L23	3.17	No	No	0	0	0
369	R:R:T284	R:R:V59	3.17	Yes	No	0	5	5
370	R:R:T86	R:R:V89	3.17	No	No	0	7	7
371	R:R:C291	R:R:L288	3.17	No	No	0	6	5
372	N:N:T306	N:N:T358	3.14	No	No	0	0	0
373	N:N:E379	N:N:P381	3.14	Yes	No	0	0	0
374	L:L:I56	L:L:S54	3.1	No	No	0	0	0
375	R:R:M240	R:R:S224	3.07	No	No	0	4	4
376	R:R:M270	R:R:S275	3.07	Yes	No	0	3	4
377	L:L:K32	L:L:S35	3.06	No	No	0	0	0
378	R:R:M270	R:R:V264	3.04	Yes	No	0	3	5
379	N:N:F357	N:N:G352	3.01	No	No	0	0	0
380	N:N:L340	N:N:S346	3	Yes	No	0	0	0
381	L:L:L102	L:L:V37	2.98	Yes	No	0	0	0
382	N:N:N339	N:N:S338	2.98	No	No	0	0	0
383	R:R:L75	R:R:V96	2.98	No	No	0	7	8
384	L:L:D92	L:L:S94	2.94	No	No	0	0	0
385	R:R:I152	R:R:I219	2.94	No	Yes	5	7	7
386	R:R:Q305	R:R:S302	2.89	No	No	0	8	6
387	N:N:Q376	N:N:V315	2.87	No	No	0	0	0
388	R:R:Q261	R:R:V197	2.87	No	No	0	6	5
389	N:N:I319	N:N:L291	2.85	No	No	0	0	0
390	N:N:I307	N:N:L359	2.85	Yes	No	0	0	0
391	N:N:I334	N:N:L340	2.85	No	Yes	0	0	0
392	R:R:I63	R:R:L288	2.85	No	No	0	7	5
393	R:R:I295	R:R:L70	2.85	No	No	0	6	6
394	R:R:I152	R:R:L223	2.85	No	No	5	7	8
395	R:R:I219	R:R:L223	2.85	Yes	No	5	7	8
396	L:L:Q101	L:L:T88	2.83	No	No	0	0	0
397	R:R:L54	R:R:M57	2.83	No	No	0	5	5
398	L:L:K86	L:L:L102	2.82	No	Yes	0	0	0
399	R:R:H135	R:R:V181	2.77	Yes	No	0	8	4
400	R:R:A177	R:R:F173	2.77	No	No	0	4	3
401	L:L:K42	L:L:Q24	2.71	No	No	0	0	0
402	L:L:K65	L:L:Q62	2.71	No	No	0	0	0
403	L:L:A119	L:L:Y51	2.67	No	Yes	0	0	0
404	R:R:A167	R:R:Y91	2.67	No	Yes	0	8	7
405	L:L:F99	L:L:S40	2.64	No	No	0	0	0
406	R:R:F215	R:R:V214	2.62	No	No	0	7	4
407	R:R:F304	R:R:T301	2.59	Yes	No	0	8	7
408	L:L:I56	N:N:F384	2.51	No	Yes	0	0	0
409	L:L:F83	L:L:K65	2.48	Yes	No	0	0	0
410	R:R:F49	R:R:L52	2.44	No	No	0	3	3
411	R:R:F64	R:R:L68	2.44	Yes	No	0	7	6
412	R:R:F64	R:R:L104	2.44	Yes	No	0	7	5
413	R:R:F299	R:R:L70	2.44	No	No	0	7	6
414	R:R:F299	R:R:L73	2.44	No	No	0	7	5
415	L:L:H76	R:R:R40	2.26	No	No	0	0	6
416	L:L:G120	L:L:G121	2.11	No	No	0	0	0
417	N:N:G302	N:N:P363	2.03	No	No	0	0	0
418	R:R:C119	R:R:G118	1.96	No	No	0	3	7
419	N:N:A386	N:N:G387	1.95	No	No	0	0	0
420	R:R:A282	R:R:P256	1.87	No	No	0	7	9
421	L:L:S74	R:R:G118	1.86	Yes	No	0	0	7
422	N:N:G350	N:N:S351	1.86	No	No	0	0	0
423	N:N:G354	N:N:S353	1.86	No	No	0	0	0
424	R:R:G103	R:R:S290	1.86	No	No	0	5	8
425	R:R:G129	R:R:S105	1.86	No	No	0	6	6
426	N:N:G354	N:N:T355	1.82	No	No	0	0	0
427	N:N:P295	N:N:S294	1.78	No	No	0	0	0
428	R:R:P208	R:R:T142	1.75	No	No	0	9	8
429	R:R:G217	R:R:M220	1.75	No	No	0	2	4
430	L:L:G63	L:L:K65	1.74	No	No	0	0	0
431	N:N:A337	N:N:S338	1.71	No	No	0	0	0
432	R:R:G67	R:R:L70	1.71	No	No	0	8	6
433	R:R:G72	R:R:L75	1.71	No	No	0	2	7
434	R:R:G129	R:R:L132	1.71	No	Yes	0	6	5
435	L:L:A31	L:L:V138	1.7	No	No	0	0	0
436	N:N:A311	N:N:V315	1.7	No	No	0	0	0
437	R:R:G67	R:R:N71	1.7	No	Yes	0	8	9
438	R:R:A116	R:R:V112	1.7	No	No	0	4	5
439	R:R:A123	R:R:V112	1.7	No	No	0	6	5
440	R:R:C145	R:R:T216	1.69	No	No	0	9	8
441	R:R:A84	R:R:T82	1.68	No	No	0	5	5
442	L:L:K32	L:L:P33	1.67	No	No	0	0	0
443	R:R:K85	R:R:P164	1.67	No	No	0	5	3
444	L:L:G61	L:L:Q62	1.64	No	No	0	0	0
445	R:R:C79	R:R:I93	1.64	No	No	0	2	5
446	R:R:C145	R:R:I212	1.64	No	No	0	9	7
447	R:R:C253	R:R:I249	1.64	No	No	0	7	6
448	R:R:L285	R:R:P256	1.64	No	No	0	7	9
449	L:L:S19	L:L:S44	1.63	No	No	0	0	0
450	L:L:S26	L:L:S40	1.63	Yes	No	0	0	0
451	R:R:A167	R:R:I90	1.62	No	No	0	8	7
452	N:N:A296	N:N:K389	1.61	No	No	0	0	0
453	N:N:D367	N:N:P366	1.61	No	No	0	0	0
454	L:L:S40	L:L:T97	1.6	No	No	0	0	0
455	L:L:V136	L:L:V138	1.6	Yes	No	0	0	0
456	N:N:S312	N:N:T289	1.6	No	Yes	0	0	0
457	N:N:S314	N:N:T355	1.6	No	No	0	0	0
458	R:R:V211	R:R:V214	1.6	No	No	0	5	4
459	R:R:V246	R:R:V296	1.6	No	No	0	8	7
460	R:R:T98	R:R:V97	1.59	Yes	No	0	8	5
461	R:R:T245	R:R:V296	1.59	No	No	0	4	7
462	L:L:A87	L:L:L102	1.58	No	Yes	0	0	0
463	R:R:P164	R:R:Q163	1.58	No	No	0	3	6
464	R:R:A239	R:R:L223	1.58	No	No	0	7	8
465	N:N:T289	N:N:T383	1.57	Yes	No	0	0	0
466	R:R:A151	R:R:D147	1.54	No	Yes	0	8	8
467	L:L:M137	L:L:T139	1.51	No	No	0	0	0
468	N:N:A296	N:N:E391	1.51	No	No	0	0	0
469	R:R:F64	R:R:G61	1.51	Yes	No	0	7	5
470	R:R:F304	R:R:G303	1.51	Yes	No	0	8	6
471	L:L:G75	R:R:R40	1.5	No	No	0	0	6
472	N:N:L340	N:N:S349	1.5	Yes	No	0	0	0
473	R:R:G232	R:R:R236	1.5	No	No	0	3	6
474	R:R:G310	R:R:R309	1.5	No	No	0	5	5
475	R:R:L37	R:R:V32	1.49	No	No	0	4	6
476	R:R:L52	R:R:V277	1.49	No	No	0	3	2
477	R:R:L73	R:R:V308	1.49	No	No	0	5	4
478	R:R:L203	R:R:V181	1.49	No	No	0	3	4
479	L:L:I112	L:L:M137	1.46	No	No	0	0	0
480	L:L:Q20	L:L:S19	1.44	No	No	0	0	0
481	N:N:Q303	N:N:S300	1.44	No	No	0	0	0
482	N:N:Q328	N:N:S326	1.44	No	No	0	0	0
483	R:R:F124	R:R:P125	1.44	No	No	0	4	5
484	R:R:P155	R:R:R154	1.44	No	No	0	8	6
485	R:R:P226	R:R:R225	1.44	No	No	0	5	4
486	N:N:I307	N:N:L297	1.43	Yes	No	0	0	0
487	R:R:I212	R:R:L247	1.43	No	No	0	7	7
488	R:R:Q241	R:R:T245	1.42	No	No	0	5	4
489	L:L:K32	L:L:L30	1.41	No	No	0	0	0
490	R:R:A199	R:R:F198	1.39	No	No	0	4	4
491	R:R:L186	R:R:L34	1.38	No	No	0	4	4
492	R:R:P268	R:R:W267	1.35	No	Yes	0	4	2
493	R:R:L229	R:R:Q231	1.33	No	No	0	2	4
494	L:L:E81	L:L:N80	1.31	No	No	0	0	0
495	R:R:R196	R:R:V197	1.31	No	No	0	3	5
496	R:R:F198	R:R:V262	1.31	No	No	0	4	5
497	R:R:R233	R:R:V237	1.31	No	No	0	3	5
498	R:R:R238	R:R:V300	1.31	No	No	0	7	6
499	N:N:D368	N:N:E365	1.3	No	No	0	0	0
500	R:R:E44	R:R:H272	1.23	Yes	No	0	4	3
501	R:R:L75	R:R:Y76	1.17	No	No	0	7	3
502	R:R:Q163	R:R:R162	1.17	No	No	0	6	7
503	R:R:Q234	R:R:R235	1.17	No	No	0	3	5
504	R:R:Q241	R:R:R238	1.17	No	No	0	5	7
505	R:R:L266	R:R:W267	1.14	No	Yes	0	4	2
506	R:R:R159	R:R:R162	1.07	Yes	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:V21	4.74	4	3	0
2	L:L:Q25	6.412	5	0	0
3	L:L:S26	3.58	4	0	0
4	L:L:I39	5.075	4	4	0
5	L:L:Y46	7.57	5	3	0
6	L:L:F48	6.358	5	3	0
7	L:L:Y51	9.5925	4	3	0
8	L:L:Y52	7.934	5	1	0
9	L:L:W55	8.01	5	4	0
10	L:L:K57	7.1125	4	0	0
11	L:L:F69	5.245	4	1	0
12	L:L:N71	7.2475	4	0	0
13	L:L:S74	4.725	4	0	0
14	L:L:F83	5.452	5	11	0
15	L:L:M100	8.3925	4	4	0
16	L:L:L102	3.028	5	4	0
17	L:L:Y113	7.1675	4	4	0
18	L:L:Y114	7.4125	4	2	0
19	L:L:R117	14.536	5	3	0
20	L:L:R124	10.57	4	7	0
21	L:L:I126	5.1975	4	1	0
22	L:L:W132	6.742	5	2	0
23	L:L:V136	4.175	4	0	0
24	N:N:T289	5.798	5	8	0
25	N:N:Q293	5.845	4	2	0
26	N:N:I307	5.2775	4	0	0
27	N:N:Y318	7.8225	4	7	0
28	N:N:Q323	6.135	4	13	0
29	N:N:L340	2.955	4	0	0
30	N:N:F348	4.2325	4	0	0
31	N:N:Y372	5.41	5	13	0
32	N:N:Y373	5.466	5	2	0
33	N:N:C374	5.8575	4	2	0
34	N:N:Q375	8.7525	4	0	0
35	N:N:E379	5.1575	4	8	0
36	N:N:Y382	8.63	4	1	0
37	N:N:F384	6.445	4	0	0
38	R:R:F35	7.11	4	14	5
39	R:R:H36	13.695	4	14	8
40	R:R:E44	4.4975	4	0	4
41	R:R:H46	9.2525	4	1	4
42	R:R:W53	12.0425	4	1	2
43	R:R:F64	5.57	4	0	7
44	R:R:N71	5.778	5	0	9
45	R:R:F78	6.572	5	0	6
46	R:R:Y91	6.048	5	0	7
47	R:R:T98	5.036	5	10	8
48	R:R:F110	11.915	4	0	7
49	R:R:Y113	6.986	5	0	6
50	R:R:Y130	6.095	4	9	6
51	R:R:F131	5.06333	6	0	5
52	R:R:L132	4.525	4	0	5
53	R:R:M134	6.522	5	9	7
54	R:R:H135	7.425	4	16	8
55	R:R:I138	6.95	4	0	8
56	R:R:F140	7.11667	6	10	7
57	R:R:D147	5.032	5	6	8
58	R:R:Y149	11.784	5	5	8
59	R:R:R159	5.4325	4	6	5
60	R:R:W175	5.375	4	10	9
61	R:R:F205	8.625	4	0	9
62	R:R:I219	3.7825	4	5	7
63	R:R:F254	6	5	0	9
64	R:R:F257	6.498	5	9	6
65	R:R:H258	9.175	4	9	8
66	R:R:R260	6.33	4	0	4
67	R:R:W267	4.2975	4	0	2
68	R:R:M270	3.82	4	0	3
69	R:R:Y279	6.69167	6	0	5
70	R:R:T284	4.41	4	0	5
71	R:R:Y297	7.2175	4	15	9
72	R:R:F304	4.96	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G135	L:L:Q25	27.8455	4.93	No	Yes	0	0	0
2	L:L:G135	L:L:Y114	29.4881	10.14	No	Yes	0	0	0
3	L:L:W132	L:L:Y114	26.8078	7.72	Yes	Yes	2	0	0
4	L:L:W132	N:N:Y322	16.5667	8.68	Yes	No	0	0	0
5	N:N:Q375	N:N:Y322	17.1565	13.53	Yes	No	0	0	0
6	L:L:F129	N:N:Q375	100	8.2	No	Yes	0	0	0
7	L:L:F129	L:L:I126	80.7514	8.79	No	Yes	1	0	0
8	L:L:I126	L:L:Y52	82.4582	4.84	Yes	Yes	1	0	0
9	L:L:N71	L:L:Y52	57.0902	11.63	Yes	Yes	0	0	0
10	L:L:N71	L:L:P72	30.3162	6.52	Yes	No	0	0	0
11	L:L:F48	L:L:P72	29.3546	14.45	Yes	No	0	0	0
12	L:L:F48	L:L:Y46	24.4554	4.13	Yes	Yes	3	0	0
13	L:L:W132	N:N:F384	17.1751	4.01	Yes	Yes	0	0	0
14	N:N:F384	N:N:Q375	82.8655	5.86	Yes	Yes	0	0	0
15	L:L:F69	L:L:Y52	33.8144	7.22	Yes	Yes	1	0	0
16	L:L:F69	L:L:Y66	55.843	5.16	Yes	No	0	0	0
17	L:L:G68	L:L:Y66	39.251	7.24	No	No	0	0	0
18	L:L:G68	L:L:I67	38.6764	3.53	No	No	0	0	0
19	L:L:F83	L:L:I67	38.1086	8.79	Yes	No	0	0	0
20	L:L:F83	L:L:K57	32.6162	4.96	Yes	Yes	0	0	0
21	L:L:K57	L:L:Y113	30.71	13.14	Yes	Yes	0	0	0
22	L:L:I39	L:L:Y113	22.2365	3.63	Yes	Yes	4	0	0
23	L:L:I39	L:L:V136	18.2195	6.14	Yes	Yes	0	0	0
24	L:L:Q25	L:L:V136	16.2371	5.73	Yes	Yes	0	0	0
25	L:L:S26	L:L:V136	15.6609	3.23	Yes	Yes	0	0	0
26	L:L:S26	L:L:S40	12.3604	1.63	Yes	No	0	0	0
27	L:L:I125	L:L:Y52	29.9359	3.63	No	Yes	1	0	0
28	L:L:L64	N:N:F384	65.1361	13.4	No	Yes	0	0	0
29	L:L:L64	N:N:Y373	63.4411	4.69	No	Yes	0	0	0
30	L:L:F69	L:L:N78	61.1242	4.83	Yes	No	0	0	0
31	L:L:N71	L:L:S74	43.53	7.45	Yes	Yes	0	0	0
32	L:L:S74	R:R:L120	37.3836	4.5	Yes	No	0	0	1
33	L:L:H76	L:L:N78	59.7502	3.83	No	No	0	0	0
34	L:L:H76	R:R:E44	58.8326	6.15	No	Yes	0	0	4
35	L:L:D130	L:L:R117	10.4085	21.44	No	Yes	3	0	0
36	L:L:I125	R:R:H46	36.5521	10.61	No	Yes	1	0	4
37	L:L:L123	R:R:L54	10.3121	4.15	No	No	0	0	5
38	R:R:L54	R:R:M57	11.1504	2.83	No	No	0	5	5
39	R:R:F110	R:R:M57	11.9852	6.22	Yes	No	0	7	5
40	R:R:F110	R:R:W53	24.1428	13.03	Yes	Yes	0	7	2
41	R:R:H46	R:R:W53	37.1436	14.81	Yes	Yes	1	4	2
42	N:N:Q293	N:N:Y373	65.0246	5.64	Yes	Yes	2	0	0
43	N:N:C374	N:N:Q293	63.4867	4.58	Yes	Yes	2	0	0
44	N:N:C374	N:N:L291	16.0952	6.35	Yes	No	2	0	0
45	N:N:I319	N:N:L291	15.0694	2.85	No	No	0	0	0
46	N:N:I319	N:N:V315	11.8956	7.68	No	No	0	0	0
47	N:N:C374	N:N:W321	47.9729	5.22	Yes	No	0	0	0
48	N:N:L359	N:N:W321	47.0299	18.22	No	No	0	0	0
49	N:N:I307	N:N:L359	21.3256	2.85	Yes	No	0	0	0
50	N:N:I307	N:N:S294	18.2127	6.19	Yes	No	0	0	0
51	N:N:S294	N:N:S308	16.1205	3.26	No	No	0	0	0
52	N:N:L359	N:N:Y372	26.4462	3.52	No	Yes	0	0	0
53	N:N:S308	N:N:T358	11.8956	3.2	No	No	0	0	0
54	N:N:P330	N:N:Q324	11.2399	6.32	No	No	2	0	0
55	R:R:H36	R:R:L120	36.978	11.57	Yes	No	0	8	1
56	R:R:E44	R:R:L41	56.6829	3.98	Yes	No	0	4	5
57	R:R:L41	R:R:Y279	56.3534	4.69	No	Yes	0	5	5
58	R:R:F257	R:R:Y279	71.2639	4.13	Yes	Yes	0	6	5
59	R:R:L45	R:R:W53	33.3463	6.83	No	Yes	1	4	2
60	R:R:H280	R:R:L45	32.1211	15.43	No	No	1	5	4
61	R:R:H280	R:R:Y279	32.1937	9.8	No	Yes	0	5	5
62	R:R:R260	R:R:Y279	18.2178	10.29	Yes	Yes	0	4	5
63	R:R:F35	R:R:H36	34.4684	9.05	Yes	Yes	14	5	8
64	R:R:F124	R:R:F35	38.7964	7.5	No	Yes	0	4	5
65	R:R:F110	R:R:H60	16.1171	11.31	Yes	No	0	7	8
66	R:R:H60	R:R:T284	10.3206	6.85	No	Yes	0	8	5
67	R:R:F124	R:R:L128	38.1339	6.09	No	No	0	4	5
68	R:R:F131	R:R:L128	37.8314	3.65	Yes	No	0	5	5
69	R:R:F131	R:R:W175	28.7834	4.01	Yes	Yes	0	5	9
70	R:R:F140	R:R:W175	25.8513	6.01	Yes	Yes	10	7	9
71	R:R:F140	R:R:L95	26.6304	6.09	Yes	No	0	7	9
72	R:R:D293	R:R:L95	28.1159	8.14	No	No	0	9	9
73	R:R:D293	R:R:D99	23.3536	6.65	No	No	0	9	9
74	R:R:D99	R:R:N71	19.9365	12.12	No	Yes	0	9	9
75	R:R:L141	R:R:L95	44.713	4.15	No	No	0	8	9
76	R:R:L141	R:R:Y297	44.0927	7.03	No	Yes	0	8	9
77	R:R:I144	R:R:Y297	24.3101	6.04	No	Yes	15	8	9
78	R:R:I144	R:R:Y91	24.7123	4.84	No	Yes	0	8	7
79	R:R:D147	R:R:Y91	20.3404	5.75	Yes	Yes	0	8	7
80	R:R:D147	R:R:P87	11.0236	4.83	Yes	No	6	8	6
81	R:R:P87	R:R:T86	10.4558	5.25	No	No	0	6	7
82	R:R:G67	R:R:N71	11.8449	1.7	No	Yes	0	8	9
83	R:R:G67	R:R:L70	10.6755	1.71	No	No	0	8	6
84	R:R:F257	R:R:M134	57.7341	7.46	Yes	Yes	9	6	7
85	R:R:F254	R:R:M134	56.3923	3.73	Yes	Yes	0	9	7
86	R:R:F257	R:R:H258	10.9983	6.79	Yes	Yes	9	6	8
87	R:R:F254	R:R:I138	15.9465	8.79	Yes	Yes	0	9	8
88	R:R:F205	R:R:H258	10.2192	19.23	Yes	Yes	0	9	8
89	R:R:I138	R:R:P208	10.4761	3.39	Yes	No	0	8	9
90	R:R:R148	R:R:Y297	14.7179	8.23	No	Yes	15	9	9
91	R:R:L243	R:R:R148	15.0778	3.64	No	No	0	7	9
92	R:R:I219	R:R:L243	11.2365	5.71	Yes	No	0	7	7
93	R:R:F254	R:R:N289	43.6652	9.67	Yes	No	0	9	9
94	R:R:R260	R:R:S275	13.3067	5.27	Yes	No	0	4	4
95	R:R:M270	R:R:S275	11.8415	3.07	Yes	No	0	3	4
96	L:L:R117	L:L:Y46	12.2674	16.46	Yes	Yes	3	0	0
97	L:L:Y66	N:N:Y382	20.9251	19.86	No	Yes	0	0	0
98	L:L:F129	N:N:Y382	19.8063	6.19	No	Yes	1	0	0
99	R:R:D293	R:R:N289	42.8118	10.77	No	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y52	R:R:R117	12.35	1	Yes	No	0	6	0	1
L:L:S74	R:R:Y113	5.09	0	Yes	Yes	0	6	0	1
L:L:S74	R:R:L120	4.5	0	Yes	No	0	1	0	1
L:L:H76	R:R:E44	6.15	0	No	Yes	0	4	0	1
L:L:K84	R:R:H272	6.55	0	No	No	0	3	0	1
L:L:G120	R:R:R117	4.5	0	No	No	0	6	0	1
L:L:F122	R:R:Y114	8.25	0	No	No	0	2	0	1
L:L:L123	R:R:L54	4.15	7	No	No	0	5	0	1
L:L:R124	R:R:P50	14.41	7	Yes	No	0	5	0	1
L:L:I125	R:R:H46	10.61	1	No	Yes	0	4	0	1
N:N:L380	R:R:G47	5.13	0	No	No	0	2	0	1
R:R:H36	R:R:L120	11.57	14	Yes	No	8	1	2	1
R:R:A39	R:R:Y113	4	0	No	Yes	8	6	2	1
R:R:E44	R:R:L41	3.98	0	Yes	No	4	5	1	2
R:R:D42	R:R:Y113	8.05	0	No	Yes	7	6	2	1
R:R:E43	R:R:H46	6.15	0	No	Yes	5	4	2	1
R:R:E43	R:R:Y113	12.35	0	No	Yes	5	6	2	1
R:R:E43	R:R:R117	9.3	0	No	No	5	6	2	1
R:R:E44	R:R:L276	6.63	0	Yes	No	4	4	1	2
R:R:H46	R:R:W53	14.81	1	Yes	Yes	4	2	1	2
R:R:H46	R:R:Y114	5.44	1	Yes	No	4	2	1	1
R:R:W53	R:R:Y114	13.5	1	Yes	No	2	2	2	1
R:R:H126	R:R:Y113	5.44	0	No	Yes	6	6	2	1
R:R:H272	R:R:H273	9.55	0	No	No	3	3	1	2
R:R:L54	R:R:M57	2.83	0	No	No	5	5	1	2
L:L:H76	R:R:R40	2.26	0	No	No	0	6	0	1
R:R:C119	R:R:G118	1.96	0	No	No	3	7	2	1
L:L:S74	R:R:G118	1.86	0	Yes	No	0	7	0	1
L:L:G75	R:R:R40	1.5	0	No	No	0	6	0	1
R:R:E44	R:R:H272	1.23	0	Yes	No	4	3	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HSC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	456
Number of Links	506
Number of Hubs	72
Number of Links mediated by Hubs	260
Number of Communities	16
Number of Nodes involved in Communities	84
Number of Links involved in Communities	103

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	143446
Length Of Smallest Path	3
Average Path Length	18.1565
Length of Longest Path	45
Minimum Path Strength	1.12
Average Path Strength	6.84579
Maximum Path Strength	22.55
Minimum Path Correlation	0.7
Average Path Correlation	0.961139
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	58.2135
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.1673
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99678
Sequence	>8HSC_nogp_Chain_R V P L F H L F A R L D E E L H G T F P G L W L A L M A V H G A I F L A G L V L N G L A L Y V F C C R T R A K T P S V I Y T I N L V V T D L L V G L S L P T R F A V Y Y G A R G C L R C A F P H V L G Y F L N M H C S I L F L T C I C V D R Y L A I V R P E G S R R C R Q P A C A R A V C A F V W L A A G A V T L S V L G V R V F A L T V L E F L L P L L V I S V F T G R I M C A L S R P G L L H Q G R Q R R V R A M Q L L L T V L I I F L V C F T P F H A R Q V A V A L W P D M P H H T S L V V Y H V A V T L S S L N S C M D P I V Y C F V T S G F Q A T V R G L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HS2	A	Orphan	Orphan	GPR20	Homo sapiens	Fab046	-	-	3.08	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HS3	A	Orphan	Orphan	GPR20	Homo sapiens	-	-	Gi1/β1/γ2	3.14	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HS3 (No Gprot)	A	Orphan	Orphan	GPR20	Homo sapiens	-	-		3.14	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HSC	A	Orphan	Orphan	GPR20	Homo sapiens	Fab046	-	Gi1/β1/γ2	3.22	2023-03-08	doi.org/10.1038/s41421-023-00520-8
	8HSC (No Gprot)	A	Orphan	Orphan	GPR20	Homo sapiens	Fab046	-		3.22	2023-03-08	doi.org/10.1038/s41421-023-00520-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HSC_nogp.zip

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