Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.2965105
2A:A:K46 5.506509
3A:A:T48 4.006599
4A:A:I49 4.942597
5A:A:F189 6.9075409
6A:A:F191 7.594105
7A:A:F196 8.6025107
8A:A:K197 7.92446
9A:A:M198 3.48407
10A:A:F199 7.514545
11A:A:Q204 4.3525449
12A:A:R208 4.65409
13A:A:K210 8.8775449
14A:A:W211 6.2975449
15A:A:H213 8.4775448
16A:A:C214 3.864547
17A:A:F215 5.865449
18A:A:I221 5.0865188
19A:A:L227 5.9675437
20A:A:Y230 8.51714738
21A:A:M243 3.195438
22A:A:M247 5.1575436
23A:A:F250 7.384539
24A:A:W258 10.2125405
25A:A:F259 6.2154189
26A:A:I265 4.0775408
27A:A:L266 3.98539
28A:A:F267 4.295499
29A:A:L268 6.985438
30A:A:N269 5.054599
31A:A:F274 5.348539
32A:A:C286 3.75536
33A:A:Y287 5.73286737
34A:A:Y290 9.9975407
35A:A:Y302 9.4725436
36A:A:F307 6.126538
37A:A:N311 5.395408
38A:A:K317 4.0025407
39A:A:Y320 5.968577117
40A:A:T324 6.0775499
41A:A:C325 4.5385197
42A:A:N331 8.0525498
43A:A:F336 5.03254108
44A:A:L353 5.6825417
45B:B:L7 6.175408
46B:B:L14 3.4325408
47B:B:T34 5.068505
48B:B:I37 4.3975402
49B:B:V40 4.92403
50B:B:I43 4.1225403
51B:B:R48 4.16527
52B:B:L51 8.13429
53B:B:H54 8.918529
54B:B:Y59 9.2275448
55B:B:W63 7.5425427
56B:B:L70 6.0575425
57B:B:V71 3.912588
58B:B:D76 6.3525429
59B:B:K78 4.862508
60B:B:L79 5.0575487
61B:B:I80 7.6925428
62B:B:I81 4.705487
63B:B:W82 10.6417629
64B:B:N88 4.3525177
65B:B:K89 5.88667629
66B:B:H91 5.965405
67B:B:I93 6.915487
68B:B:L95 4.214588
69B:B:W99 6.42749
70B:B:Y105 4.23143786
71B:B:N110 5.89454
72B:B:Y111 5.40667654
73B:B:C114 3.9775488
74B:B:L117 5.306549
75B:B:C121 3.7375458
76B:B:I123 4.058556
77B:B:Y124 5.00333686
78B:B:L126 4.185485
79B:B:T128 2.605403
80B:B:V133 6.495484
81B:B:H142 7.77667659
82B:B:Y145 5.81857748
83B:B:C149 4.25458
84B:B:F151 4.498559
85B:B:L152 4.24563
86B:B:I157 3.72833657
87B:B:V158 3.9175465
88B:B:T159 5.08667659
89B:B:D163 7.46559
90B:B:W169 9.54333658
91B:B:F180 7.9875467
92B:B:H183 7.315669
93B:B:D186 6.03549
94B:B:V187 4.748569
95B:B:L190 3.575465
96B:B:L192 3.91465
97B:B:F199 6.755669
98B:B:V200 8.4525476
99B:B:S201 4.915469
100B:B:C204 6.7075447
101B:B:D205 6.048569
102B:B:K209 5.88333666
103B:B:L210 5.112505
104B:B:W211 9.06333668
105B:B:Q220 8.415477
106B:B:F222 9.7175478
107B:B:H225 9.79667679
108B:B:D228 8.6475449
109B:B:F234 5.4375475
110B:B:F235 8.078336156
111B:B:P236 8.1554157
112B:B:F241 8.16833676
113B:B:T243 5.232578
114B:B:D247 5.558579
115B:B:R251 8.906578
116B:B:F253 7.97576
117B:B:D258 11.365477
118B:B:Q259 4.7875406
119B:B:F278 7.055157
120B:B:R283 7.1885229
121B:B:L284 4.33254235
122B:B:Y289 6.812867127
123B:B:D290 7.885406
124B:B:D291 5.82754128
125B:B:N295 5.43254126
126B:B:V296 3.63405
127B:B:W297 6.7554128
128B:B:K301 4.034505
129B:B:R304 7.03254125
130B:B:H311 8.9465139
131B:B:L318 3.025406
132B:B:M325 5.9475425
133B:B:W332 12.1083649
134B:B:D333 4.90754139
135B:B:L336 4.9625427
136B:B:K337 9.1554136
137B:B:W339 9.6965139
138G:G:Y40 11.264156
139G:G:D48 4.3675409
140G:G:L51 4.225406
141G:G:N59 6.7075429
142G:G:P60 7.855429
143G:G:F61 4.47375828
144R:R:F35 9.185165
145R:R:L45 5.7475414
146R:R:F49 4.435403
147R:R:W53 7.534512
148R:R:L56 5.71416
149R:R:F78 6.29254146
150R:R:Y91 4.844507
151R:R:I93 3.7325405
152R:R:V102 3.5175406
153R:R:F124 3.565404
154R:R:H126 6.9065166
155R:R:M134 6.2975417
156R:R:R148 5.4525419
157R:R:Y149 8.9125268
158R:R:R196 8.414513
159R:R:L223 3.65408
160R:R:R235 4.853336115
161R:R:M240 3.66404
162R:R:F250 4.992519
163R:R:F254 9.458519
164R:R:F257 6.954516
165R:R:H258 8.355418
166R:R:R260 5.194514
167R:R:Q261 6.9725416
168R:R:L276 3.91414
169R:R:Y279 5.84286715
170R:R:D293 7.108519
171R:R:Y297 6.844519
172R:R:C298 7.194147
173R:R:F299 7.264147
174R:R:F304 7.074297148
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I19 A:A:R15 12.00715.01NoNo095
2A:A:R15 B:B:H91 12.09213.39NoYes055
3A:A:I19 B:B:K89 11.86842.91NoYes099
4A:A:Q204 B:B:N119 41.93163.96YesNo099
5B:B:G144 B:B:N119 41.36795.09NoNo089
6B:B:D163 B:B:G144 41.18583.35YesNo098
7B:B:D163 B:B:H142 40.08276.3YesYes599
8B:B:H142 B:B:T159 30.84226.85YesYes599
9B:B:C149 B:B:T159 25.0553.38YesYes589
10B:B:C149 B:B:T102 27.05585.07YesNo088
11B:B:C148 B:B:T102 26.9753.38NoNo068
12B:B:C148 B:B:R150 19.36626.96NoNo066
13B:B:H62 B:B:R150 20.57912.41NoNo066
14B:B:H62 B:B:Y105 20.47814.36NoYes066
15B:B:I81 B:B:Y105 12.044.84YesYes876
16B:B:H91 B:B:I81 12.17336.63YesYes057
17A:A:Q204 A:A:W211 35.14336.57YesYes499
18A:A:R208 A:A:W211 56.18356YesYes099
19A:A:L249 A:A:R208 55.48233.64NoYes099
20A:A:F223 A:A:L249 55.41584.87NoNo099
21A:A:F223 A:A:F250 55.379216.08NoYes099
22A:A:F250 A:A:L266 91.82354.87YesYes399
23A:A:L266 A:A:L268 92.59664.15YesYes398
24A:A:L227 A:A:L268 92.868711.07YesYes378
25A:A:F274 A:A:L227 94.93534.87YesYes397
26A:A:F274 A:A:Y296 1003.09YesNo094
27A:A:K271 A:A:Y296 99.96212.39NoNo054
28A:A:C325 A:A:K271 99.94294.85YesNo075
29A:A:C325 A:A:D328 99.86386.22YesNo079
30A:A:D328 A:A:N331 99.80226.73NoYes098
31A:A:F267 A:A:N331 92.59014.83YesYes998
32A:A:F267 A:A:I265 94.39433.77YesYes098
33A:A:F259 A:A:I221 38.74156.28YesYes1898
34A:A:W211 B:B:Y145 23.61475.79YesYes498
35A:A:K210 B:B:Y145 23.96393.58YesYes498
36A:A:K210 B:B:D228 23.812111.06YesYes499
37A:A:H213 A:A:W258 38.811213.75YesYes085
38A:A:H213 B:B:W332 40.55687.41YesYes489
39A:A:I221 A:A:I264 41.15884.42YesNo086
40A:A:F250 A:A:I264 41.85395.02YesNo096
41A:A:F259 A:A:N256 39.08869.67YesNo098
42A:A:N256 A:A:W258 39.04816.78NoYes085
43A:A:A338 A:A:I265 95.88164.87NoYes068
44A:A:A338 A:A:Y320 95.84266.67NoYes067
45A:A:E318 A:A:Y320 47.75924.49NoYes1147
46A:A:E318 R:R:R235 47.71893.49NoYes1145
47A:A:D341 A:A:Y320 47.8829.2NoYes1187
48A:A:D341 R:R:R235 47.67775.96NoYes1185
49A:A:F354 R:R:R235 95.14985.34NoYes055
50A:A:F354 R:R:S302 94.73919.25NoNo056
51R:R:G303 R:R:S302 94.53343.71NoNo066
52R:R:G303 R:R:T301 94.32751.82NoNo067
53R:R:F304 R:R:T301 93.91512.59YesNo087
54R:R:F304 R:R:F78 90.71826.43YesYes1486
55R:R:F78 R:R:I93 90.52883.77YesYes065
56R:R:I93 R:R:V89 89.47413.07YesNo057
57R:R:T86 R:R:V89 89.26253.17NoNo077
58R:R:P87 R:R:T86 88.83883.5NoNo067
59R:R:A167 R:R:P87 88.62663.74NoNo086
60R:R:A167 R:R:Y91 86.27854NoYes087
61R:R:I144 R:R:Y91 79.0114.84NoYes087
62B:B:L14 B:B:Q17 10.69661.33YesNo084
63B:B:Q17 G:G:A23 11.02011.52NoNo048
64B:B:I18 G:G:A23 11.34751.62NoNo078
65B:B:I18 B:B:R22 11.68015.01NoNo076
66B:B:D258 B:B:R22 12.217413.1YesNo076
67G:G:D48 G:G:L50 11.02154.07YesNo099
68B:B:L284 G:G:L50 11.53194.15YesNo2359
69B:B:I43 B:B:L284 15.00385.71YesYes035
70B:B:I43 B:B:V40 38.22594.61YesYes033
71B:B:D298 B:B:V40 23.66568.76NoYes093
72B:B:D298 B:B:R283 15.965413.1NoYes099
73B:B:I37 B:B:R283 16.54828.77YesYes029
74B:B:I37 B:B:T34 25.43053.04YesYes025
75B:B:V40 G:G:L51 15.80024.47YesYes036
76B:B:R283 G:G:L51 16.8914.86YesYes096
77B:B:L300 B:B:R283 16.48483.64NoYes2269
78B:B:L300 B:B:T34 16.748610.32NoYes065
79B:B:L30 B:B:T34 42.33164.42NoYes055
80B:B:L30 B:B:M262 42.3555.65NoNo054
81B:B:I43 B:B:M45 21.38942.92YesNo034
82B:B:L308 B:B:M45 20.69767.07NoNo074
83B:B:L308 B:B:W339 17.372619.36NoYes079
84B:B:D258 B:B:F222 12.70048.36YesYes778
85B:B:D228 B:B:S227 25.29435.89YesNo096
86B:B:D247 B:B:S227 24.99982.94YesNo096
87B:B:D247 B:B:H225 18.15345.04YesYes799
88B:B:F222 B:B:F253 13.530313.93YesYes786
89B:B:F253 B:B:R251 11.92423.21YesYes768
90B:B:M262 B:B:Y264 42.420211.97NoNo045
91B:B:W297 B:B:Y264 44.99164.82YesNo085
92B:B:W297 B:B:Y289 44.3658.68YesYes1287
93B:B:R314 B:B:W332 43.57427.99NoYes089
94B:B:D290 B:B:R314 43.48619.06YesNo068
95B:B:C271 B:B:D290 43.23153.11NoYes056
96B:B:C271 B:B:Y289 42.30635.38NoYes1257
97R:R:I144 R:R:Y297 69.92867.25NoYes189
98R:R:L141 R:R:Y297 34.05665.86NoYes189
99R:R:F250 R:R:L141 33.84594.87YesNo198
100R:R:F250 R:R:F254 31.40366.43YesYes199
101R:R:F254 R:R:S286 62.3985.28YesNo198
102R:R:M134 R:R:S286 55.18734.6YesNo178
103R:R:F257 R:R:M134 50.714512.44YesYes167
104R:R:F257 R:R:Y279 41.06414.13YesYes165
105R:R:D293 R:R:Y297 35.34466.9YesYes199
106R:R:D293 R:R:N289 32.675313.46YesNo199
107R:R:F254 R:R:N289 31.405210.87YesNo199
108R:R:Y130 R:R:Y279 10.63836.95NoYes165
109R:R:R109 R:R:Y130 10.11044.12NoNo066
110R:R:H280 R:R:Y279 28.01347.62NoYes155
111R:R:H280 R:R:L45 16.38849NoYes154
112R:R:H280 R:R:L56 11.10187.71NoYes156
113R:R:L276 R:R:L45 11.6534.15YesYes144
114B:B:H225 B:B:T243 11.66368.21YesYes798
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HS3
Class A
SubFamily Orphan
Type Orphan
SubType GPR20
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.14
Date 2023-03-08 
D.O.I. 10.1038/s41421-023-00520-8
Net Summary
Imin 2.89
Number of Linked Nodes 836
Number of Links 1040
Number of Hubs 174
Number of Links mediated by Hubs 625
Number of Communities 28
Number of Nodes involved in Communities 269
Number of Links involved in Communities 390
Path Summary
Number Of Nodes in MetaPath 115
Number Of Links MetaPath 114
Number of Shortest Paths 1500777
Length Of Smallest Path 3
Average Path Length 40.7723
Length of Longest Path 83
Minimum Path Strength 1.175
Average Path Strength 6.01255
Maximum Path Strength 23.525
Minimum Path Correlation 0.72
Average Path Correlation 0.986759
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 42.0629
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.3209
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • receptor complex   • periplasmic space
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8HS3_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKN 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HS3_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HS3_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99678
Sequence
>8HS3_Chain_R
VPLFHLFAR LDEELHGTF PGLWLALMA VHGAIFLAG LVLNGLALY 
VFCCRTAKT PSVIYTINL VVTDLLVGL SLPTRFAVY YGARGCLRC 
AFPHVLGYF LNMHCSILF LTCICVDRY LAIVRPEGS RRCRQPACA 
RAVCAFVWL AAGAVTLSV LGVTGSRPC CRVFALTVL EFLLPLLVI 
SVFTGRIMC ALSRPGLLH QGRQRRVRA MQLLLTVLI IFLVCFTPF 
HARQVAVAL WPDMPHHTS LVVYHVAVT LSSLNSCMD PIVYCFVTS 
GFQATVRGL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HS2AOrphanOrphanGPR20Homo sapiensFab046--3.082023-03-0810.1038/s41421-023-00520-8
8HSCAOrphanOrphanGPR20Homo sapiensFab046-Gi1/β1/γ23.222023-03-0810.1038/s41421-023-00520-8
8HSC (No Gprot) AOrphanOrphanGPR20Homo sapiensFab046-3.222023-03-0810.1038/s41421-023-00520-8
8HS3AOrphanOrphanGPR20Homo sapiens--Gi1/β1/γ23.142023-03-0810.1038/s41421-023-00520-8
8HS3 (No Gprot) AOrphanOrphanGPR20Homo sapiens--3.142023-03-0810.1038/s41421-023-00520-8




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