Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.8754105
2A:A:K46 5.506509
3A:A:I49 4.9425127
4A:A:F189 6.9075409
5A:A:F191 7.594105
6A:A:F196 8.6025107
7A:A:K197 7.92426
8A:A:F199 7.514525
9A:A:R208 4.65409
10A:A:K210 8.8775429
11A:A:W211 6.2975429
12A:A:C214 4.0925427
13A:A:F215 5.865429
14A:A:I221 5.62254158
15A:A:L227 5.9675457
16A:A:Y230 8.51714758
17A:A:F250 7.384559
18A:A:W258 10.2125405
19A:A:F259 6.2154159
20A:A:I265 4.0775408
21A:A:L266 4.2375459
22A:A:F267 4.2954129
23A:A:N269 5.58754129
24A:A:F274 5.348559
25A:A:C286 3.95406
26A:A:Y287 5.732867167
27A:A:Y290 9.9975407
28A:A:Y302 9.47254166
29A:A:F307 6.126558
30A:A:N311 5.395408
31A:A:Y320 5.96857797
32A:A:T324 6.07754129
33A:A:C325 4.895407
34A:A:N331 8.05254128
35A:A:F336 5.03254108
36A:A:L353 5.6825417
37B:B:L7 6.175408
38B:B:L14 3.4325408
39B:B:T34 5.068505
40B:B:V40 4.92403
41B:B:R48 4.16537
42B:B:L51 8.13439
43B:B:H54 8.918539
44B:B:Y59 9.2275428
45B:B:W63 7.5425407
46B:B:V71 3.912588
47B:B:D76 6.3525439
48B:B:K78 5.35408
49B:B:L79 5.0575487
50B:B:I81 4.705487
51B:B:W82 10.6417639
52B:B:N88 4.6954217
53B:B:K89 6.482539
54B:B:H91 5.965405
55B:B:I93 6.915487
56B:B:L95 4.214588
57B:B:W99 6.42729
58B:B:Y105 4.23143786
59B:B:N110 5.89444
60B:B:Y111 5.40667644
61B:B:C114 3.9775488
62B:B:L117 5.306529
63B:B:C121 3.7375448
64B:B:I123 4.3375446
65B:B:Y124 5.00333686
66B:B:T128 2.605403
67B:B:H142 8.746549
68B:B:Y145 5.81857728
69B:B:C149 4.25448
70B:B:F151 4.498549
71B:B:L152 4.555403
72B:B:I157 4.1225447
73B:B:T159 5.514549
74B:B:D163 7.46549
75B:B:W169 9.54333648
76B:B:F180 7.9875477
77B:B:H183 7.315679
78B:B:D186 6.4775429
79B:B:V187 4.748579
80B:B:F199 6.755679
81B:B:S201 4.915479
82B:B:C204 6.7075427
83B:B:D205 6.048579
84B:B:K209 5.88333676
85B:B:L210 5.645405
86B:B:W211 9.06333678
87B:B:Q220 8.415467
88B:B:F222 9.7175468
89B:B:H225 9.79667669
90B:B:D228 8.6475429
91B:B:F234 5.4375465
92B:B:F235 8.078336146
93B:B:P236 8.1554147
94B:B:F241 8.16833666
95B:B:T243 5.232568
96B:B:D247 6.2125469
97B:B:R251 8.906568
98B:B:F253 7.97566
99B:B:D258 11.365467
100B:B:F278 7.055147
101B:B:R283 7.1885189
102B:B:L284 4.33254195
103B:B:Y289 6.812867117
104B:B:D290 7.885406
105B:B:D291 5.82754118
106B:B:V296 3.63405
107B:B:W297 6.7554118
108B:B:K301 4.034505
109B:B:R304 7.03254115
110B:B:H311 7.2725139
111B:B:M325 5.9475405
112B:B:W332 12.1083629
113B:B:D333 4.90754139
114B:B:L336 4.9625437
115B:B:K337 9.1554136
116B:B:W339 9.6965139
117G:G:Y40 11.264146
118G:G:D48 4.3675409
119G:G:L51 4.225406
120G:G:N59 6.7075439
121G:G:F61 4.7738
122R:R:F64 2.39407
123R:R:N71 6.8525419
124R:R:F78 3.535406
125R:R:Y91 4.844507
126R:R:V102 3.5175406
127R:R:H126 5.0225406
128R:R:F131 3.3575405
129R:R:M134 6.2975417
130R:R:R148 5.4525419
131R:R:Y149 8.5675408
132R:R:L223 3.65408
133R:R:R235 4.85333695
134R:R:M240 3.66404
135R:R:F250 4.992519
136R:R:F254 9.458519
137R:R:F257 6.954516
138R:R:H258 8.355418
139R:R:R260 4.41514
140R:R:Y279 6.23615
141R:R:D293 7.108519
142R:R:V296 1.985407
143R:R:Y297 6.844519
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I93 B:B:P94 15.82613.39YesNo075
2B:B:K78 B:B:P94 15.79083.35YesNo085
3B:B:D76 B:B:K78 15.76256.91YesYes098
4B:B:D76 B:B:H54 15.61775.04YesYes399
5A:A:Q204 B:B:N119 32.59363.96NoNo099
6B:B:G144 B:B:N119 32.14375.09NoNo089
7B:B:D163 B:B:G144 31.99493.35YesNo098
8B:B:D163 B:B:H142 30.96036.3YesYes499
9B:B:H142 B:B:T159 24.97846.85YesYes499
10B:B:C149 B:B:T159 22.30593.38YesYes489
11B:B:C149 B:B:T102 25.17655.07YesNo088
12B:B:C148 B:B:T102 25.15083.38NoNo068
13B:B:C148 B:B:R150 15.02556.96NoNo066
14B:B:H62 B:B:R150 19.061612.41NoNo066
15B:B:H62 B:B:Y105 18.97744.36NoYes066
16A:A:Q204 A:A:W211 27.46086.57NoYes299
17A:A:R208 A:A:W211 29.326YesYes099
18A:A:L249 A:A:R208 28.95933.64NoYes099
19A:A:F223 A:A:L249 28.94744.87NoNo099
20A:A:F223 A:A:F250 28.846816.08NoYes099
21A:A:F250 A:A:L266 95.2734.87YesYes599
22A:A:L266 A:A:L268 96.10144.15YesNo598
23A:A:L227 A:A:L268 95.212411.07YesNo578
24A:A:F274 A:A:L227 96.17394.87YesYes597
25A:A:F274 A:A:Y296 1003.09YesNo094
26A:A:K271 A:A:Y296 99.75082.39NoNo054
27A:A:C325 A:A:K271 99.62574.85YesNo075
28A:A:C325 A:A:D328 99.24836.22YesNo079
29A:A:D328 A:A:N331 98.86786.73NoYes098
30A:A:F267 A:A:N331 89.15234.83YesYes1298
31A:A:F267 A:A:I265 89.45693.77YesYes098
32A:A:F259 A:A:I221 75.09146.28YesYes1598
33A:A:H213 A:A:W258 75.285813.75NoYes085
34B:B:W332 B:B:Y59 10.942811.58YesYes298
35A:A:I221 A:A:I264 77.24.42YesNo086
36A:A:F250 A:A:I264 77.10425.02YesNo096
37A:A:F259 A:A:N256 75.28399.67YesNo098
38A:A:A338 A:A:I265 88.81884.87NoYes068
39A:A:A338 A:A:Y320 88.67176.67NoYes067
40A:A:E318 A:A:Y320 43.85454.49NoYes947
41A:A:E318 R:R:R235 43.70543.49NoYes945
42A:A:D341 A:A:Y320 44.07329.2NoYes987
43A:A:D341 R:R:R235 43.67065.96NoYes985
44A:A:F354 R:R:R235 86.70485.34NoYes055
45A:A:F354 R:R:S302 85.89629.25NoNo056
46R:R:G303 R:R:S302 85.49143.71NoNo066
47R:R:G303 R:R:T301 85.08621.82NoNo067
48R:R:F304 R:R:T301 84.27492.59NoNo087
49R:R:F304 R:R:F78 83.86872.14NoYes086
50R:R:F78 R:R:T92 81.83255.19YesNo068
51R:R:T92 R:R:V96 81.42431.59NoNo088
52R:R:N71 R:R:V96 79.787810.35YesNo098
53R:R:N71 R:R:P294 76.32064.89YesNo199
54R:R:D293 R:R:P294 76.08581.61YesNo199
55R:R:D293 R:R:Y297 36.45456.9YesYes199
56R:R:R148 R:R:Y297 16.74544.12YesYes199
57B:B:F199 B:B:W211 12.756612.03YesYes798
58G:G:E22 G:G:L19 10.60071.33NoNo099
59B:B:I338 B:B:L51 13.20267.14NoYes359
60B:B:I338 G:G:F61 12.14195.02NoYes358
61B:B:M325 G:G:F61 21.7063.73YesYes058
62B:B:M325 G:G:P49 34.47935.03YesNo057
63G:G:D48 G:G:P49 35.0254.83YesNo097
64G:G:D48 G:G:L50 35.80864.07YesNo099
65B:B:L284 G:G:L50 36.30374.15YesNo1959
66B:B:I43 B:B:L284 58.60725.71NoYes035
67B:B:I43 B:B:V40 84.13044.61NoYes033
68B:B:D298 B:B:V40 51.24648.76NoYes093
69B:B:D298 B:B:R283 34.263313.1NoYes099
70B:B:I37 B:B:R283 34.75188.77NoYes029
71B:B:I37 B:B:T34 52.58623.04NoYes025
72B:B:V40 G:G:L51 34.23164.47YesYes036
73B:B:R283 G:G:L51 35.17844.86YesYes096
74B:B:D298 B:B:K301 17.38396.91NoYes095
75B:B:I37 B:B:K301 17.84924.36NoYes025
76B:B:L300 B:B:R283 34.74733.64NoYes1869
77B:B:L300 B:B:T34 34.963910.32NoYes065
78B:B:L30 B:B:T34 86.34174.42NoYes055
79B:B:R314 B:B:W332 86.420227.99NoYes089
80B:B:D290 B:B:R314 86.440719.06YesNo068
81B:B:C271 B:B:D290 86.56483.11NoYes056
82B:B:C271 B:B:Y289 85.80995.38NoYes1157
83B:B:W297 B:B:Y289 90.06778.68YesYes1187
84B:B:W297 B:B:Y264 90.68854.82YesNo085
85B:B:M262 B:B:Y264 86.150611.97NoNo045
86B:B:L30 B:B:M262 86.25925.65NoNo054
87B:B:A305 B:B:I43 25.03773.25NoNo043
88B:B:L284 B:B:V296 27.42314.47YesYes055
89B:B:A305 B:B:V296 24.31343.39NoYes045
90B:B:L286 B:B:V296 48.72772.98NoYes075
91B:B:L286 B:B:V327 47.30028.94NoNo076
92B:B:V320 B:B:V327 45.87233.21NoNo076
93B:B:S277 B:B:V320 44.44414.85NoNo057
94B:B:L318 B:B:S277 41.58673NoNo065
95B:B:C294 B:B:L318 40.15743.17NoNo056
96B:B:C294 B:B:L308 38.72799.52NoNo057
97B:B:L308 B:B:W339 35.867719.36NoYes079
98B:B:K337 B:B:W339 18.65618.12YesYes1369
99B:B:T329 B:B:W339 12.9168.49NoYes089
100B:B:H311 B:B:T329 11.48239.58YesNo098
101B:B:D333 B:B:H311 11.48543.78YesYes1399
102B:B:H311 B:B:K337 11.485110.48YesYes1396
103B:B:L79 B:B:V71 16.02954.47YesYes878
104B:B:I93 B:B:L79 14.48247.14YesYes877
105B:B:C148 B:B:L190 10.91253.17NoNo065
106B:B:F222 B:B:F253 10.35213.93YesYes686
107B:B:F253 B:B:T243 13.81845.19YesYes668
108B:B:G244 B:B:T243 22.21493.64NoYes058
109B:B:I273 B:B:Y289 23.591513.3NoYes067
110B:B:G244 B:B:I273 23.10273.53NoNo056
111R:R:D293 R:R:N289 26.715813.46YesNo199
112R:R:F254 R:R:N289 24.914910.87YesNo199
113R:R:F254 R:R:S286 23.97625.28YesNo198
114R:R:M134 R:R:S286 17.87114.6YesNo178
115R:R:F257 R:R:M134 13.230512.44YesYes167
116R:R:I144 R:R:Y297 15.41977.25NoYes189
117R:R:I144 R:R:Y91 15.17034.84NoYes087
118R:R:D293 R:R:L141 13.28148.14YesNo198
119R:R:F250 R:R:L141 13.51624.87YesNo198
120R:R:F250 R:R:I212 10.48843.77YesNo097
121R:R:F140 R:R:V174 15.43635.24NoNo077
122R:R:F140 R:R:W175 12.71944.01NoNo079
123B:B:V71 B:B:Y105 16.46673.79YesYes886
124A:A:N256 A:A:W258 75.29766.78NoYes085
125A:A:H213 B:B:W332 75.07077.41NoYes289
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HS3
Class A
SubFamily Orphan
Type A orphans
SubType GPR20
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.14
Date 2023-03-08 
D.O.I. 10.1038/s41421-023-00520-8
Net Summary
Imin 3.04
Number of Linked Nodes 763
Number of Links 903
Number of Hubs 143
Number of Links mediated by Hubs 538
Number of Communities 22
Number of Nodes involved in Communities 204
Number of Links involved in Communities 286
Path Summary
Number Of Nodes in MetaPath 126
Number Of Links MetaPath 125
Number of Shortest Paths 1045404
Length Of Smallest Path 3
Average Path Length 39.4022
Length of Longest Path 77
Minimum Path Strength 1.175
Average Path Strength 6.31931
Maximum Path Strength 23.525
Minimum Path Correlation 0.71
Average Path Correlation 0.983896
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 48.9129
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.342
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8HS3_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKN 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HS3_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HS3_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99678
Sequence
>8HS3_Chain_R
VPLFHLFAR LDEELHGTF PGLWLALMA VHGAIFLAG LVLNGLALY 
VFCCRTAKT PSVIYTINL VVTDLLVGL SLPTRFAVY YGARGCLRC 
AFPHVLGYF LNMHCSILF LTCICVDRY LAIVRPEGS RRCRQPACA 
RAVCAFVWL AAGAVTLSV LGVTGSRPC CRVFALTVL EFLLPLLVI 
SVFTGRIMC ALSRPGLLH QGRQRRVRA MQLLLTVLI IFLVCFTPF 
HARQVAVAL WPDMPHHTS LVVYHVAVT LSSLNSCMD PIVYCFVTS 
GFQATVRGL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HS2AOrphanA orphansGPR20Homo sapiensFab046--3.082023-03-0810.1038/s41421-023-00520-8
8HS3AOrphanA orphansGPR20Homo sapiens--Gi1/&β;1/&γ;23.142023-03-0810.1038/s41421-023-00520-8
8HSCAOrphanA orphansGPR20Homo sapiensFab046-Gi1/&β;1/&γ;23.222023-03-0810.1038/s41421-023-00520-8




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HS3.zip



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