psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P33	R:R:V32	5.3	No	No	0	5	6
2	R:R:L34	R:R:L37	2.77	No	No	0	4	4
3	R:R:F38	R:R:L34	7.31	No	No	0	5	4
4	R:R:L34	R:R:R196	7.29	No	Yes	0	4	3
5	R:R:A39	R:R:F35	4.16	No	Yes	2	8	5
6	R:R:F35	R:R:L120	9.74	Yes	No	2	5	1
7	R:R:A123	R:R:F35	5.55	No	Yes	2	6	5
8	R:R:F35	R:R:H126	6.79	Yes	Yes	2	5	6
9	R:R:F35	R:R:V127	19.66	Yes	No	2	5	4
10	R:R:H36	R:R:L120	16.71	No	No	0	8	1
11	R:R:L37	R:R:L41	2.77	No	No	0	4	5
12	R:R:F38	R:R:Y279	8.25	No	Yes	0	5	5
13	R:R:A39	R:R:L120	3.15	No	No	2	8	1
14	R:R:L41	R:R:Y279	3.52	No	Yes	0	5	5
15	R:R:D42	R:R:E43	3.9	No	No	4	7	5
16	R:R:D42	R:R:Y113	10.34	No	No	4	7	6
17	R:R:E43	R:R:Y113	10.1	No	No	4	5	6
18	R:R:E44	R:R:T48	5.64	No	No	0	4	2
19	R:R:E44	R:R:H272	11.08	No	No	1	4	3
20	R:R:E44	R:R:L276	3.98	No	Yes	1	4	4
21	R:R:L45	R:R:W53	5.69	Yes	Yes	1	4	2
22	R:R:L45	R:R:L56	4.15	Yes	Yes	1	4	6
23	R:R:L276	R:R:L45	4.15	Yes	Yes	1	4	4
24	R:R:H280	R:R:L45	9	No	Yes	1	5	4
25	R:R:H46	R:R:W53	3.17	No	Yes	0	4	2
26	R:R:H46	R:R:Y113	6.53	No	No	0	4	6
27	R:R:F49	R:R:T48	7.78	Yes	No	0	3	2
28	R:R:F49	R:R:L52	4.87	Yes	No	0	3	3
29	R:R:F49	R:R:L276	3.65	Yes	Yes	0	3	4
30	R:R:G51	R:R:L54	5.13	No	No	0	3	5
31	R:R:L52	R:R:L56	4.15	No	Yes	0	3	6
32	R:R:L52	R:R:V277	4.47	No	No	0	3	2
33	R:R:L56	R:R:W53	6.83	Yes	Yes	1	6	2
34	R:R:M57	R:R:W53	13.96	No	Yes	1	5	2
35	R:R:F110	R:R:W53	8.02	No	Yes	1	7	2
36	R:R:H280	R:R:L56	7.71	No	Yes	1	5	6
37	R:R:F110	R:R:M57	6.22	No	No	1	7	5
38	R:R:H60	R:R:T284	4.11	No	No	0	8	5
39	R:R:I63	R:R:S287	4.64	No	No	0	7	7
40	R:R:I63	R:R:S290	3.1	No	No	0	7	8
41	R:R:F64	R:R:L68	3.65	No	No	0	7	6
42	R:R:F64	R:R:P107	20.23	No	No	0	7	9
43	R:R:L100	R:R:L68	5.54	No	No	0	5	6
44	R:R:I295	R:R:L70	4.28	No	No	3	6	6
45	R:R:F299	R:R:L70	6.09	Yes	No	3	7	6
46	R:R:N71	R:R:V96	10.35	No	No	0	9	8
47	R:R:D99	R:R:N71	9.42	No	No	1	9	9
48	R:R:N71	R:R:P294	4.89	No	No	1	9	9
49	R:R:G72	R:R:L75	5.13	No	No	0	2	7
50	R:R:A74	R:R:C298	3.61	No	Yes	0	8	7
51	R:R:L100	R:R:L75	2.77	No	No	0	5	7
52	R:R:C80	R:R:Y76	5.38	No	No	0	4	3
53	R:R:F304	R:R:V77	10.49	Yes	No	0	8	6
54	R:R:F78	R:R:T92	5.19	Yes	No	0	6	8
55	R:R:F78	R:R:I93	3.77	Yes	Yes	0	6	5
56	R:R:C298	R:R:F78	9.78	Yes	Yes	3	7	6
57	R:R:F304	R:R:F78	6.43	Yes	Yes	3	8	6
58	R:R:C79	R:R:I93	6.55	No	Yes	0	2	5
59	R:R:P87	R:R:T86	3.5	No	No	0	6	7
60	R:R:T86	R:R:V89	3.17	No	No	0	7	7
61	R:R:A167	R:R:P87	3.74	No	No	0	8	6
62	R:R:D147	R:R:S88	4.42	No	No	0	8	7
63	R:R:I93	R:R:V89	3.07	Yes	No	0	5	7
64	R:R:I90	R:R:R168	13.78	No	No	0	7	4
65	R:R:C143	R:R:Y91	9.41	No	Yes	0	6	7
66	R:R:I144	R:R:Y91	4.84	No	Yes	0	8	7
67	R:R:D147	R:R:Y91	3.45	No	Yes	0	8	7
68	R:R:A167	R:R:Y91	4	No	Yes	0	8	7
69	R:R:F140	R:R:N94	18.12	Yes	No	5	7	9
70	R:R:C171	R:R:N94	7.87	No	No	5	7	9
71	R:R:D293	R:R:L95	5.43	Yes	No	0	9	9
72	R:R:C136	R:R:T98	5.07	No	No	0	6	8
73	R:R:D99	R:R:S290	8.83	No	No	0	9	8
74	R:R:D99	R:R:P294	4.83	No	No	1	9	9
75	R:R:L101	R:R:L132	9.69	No	No	0	7	5
76	R:R:L132	R:R:V102	5.96	No	Yes	0	5	6
77	R:R:N133	R:R:V102	4.43	No	Yes	0	8	6
78	R:R:G103	R:R:L106	5.13	No	No	0	5	8
79	R:R:L106	R:R:P107	4.93	No	No	0	8	9
80	R:R:H126	R:R:R109	6.77	Yes	No	0	6	6
81	R:R:R109	R:R:Y130	4.12	No	No	0	6	6
82	R:R:H126	R:R:V112	13.84	Yes	No	0	6	5
83	R:R:A123	R:R:H126	4.39	No	Yes	2	6	6
84	R:R:F124	R:R:P125	4.33	Yes	No	0	4	5
85	R:R:F124	R:R:L128	4.87	Yes	No	0	4	5
86	R:R:H126	R:R:V127	2.77	Yes	No	2	6	4
87	R:R:Y130	R:R:Y279	6.95	No	Yes	1	6	5
88	R:R:V283	R:R:Y130	5.05	No	No	1	5	6
89	R:R:F131	R:R:W175	4.01	No	No	0	5	9
90	R:R:F131	R:R:G179	3.01	No	No	0	5	3
91	R:R:F131	R:R:T182	14.27	No	No	0	5	6
92	R:R:M134	R:R:N133	4.21	Yes	No	1	7	8
93	R:R:N133	R:R:S286	7.45	No	No	1	8	8
94	R:R:F257	R:R:M134	12.44	Yes	Yes	1	6	7
95	R:R:H258	R:R:M134	3.94	Yes	Yes	1	8	7
96	R:R:M134	R:R:S286	4.6	Yes	No	1	7	8
97	R:R:H135	R:R:T182	13.69	No	No	0	8	6
98	R:R:H135	R:R:L200	5.14	No	No	0	8	5
99	R:R:E204	R:R:H135	12.31	No	No	0	5	8
100	R:R:C136	R:R:W175	5.22	No	No	0	6	9
101	R:R:I138	R:R:P208	3.39	No	No	0	8	9
102	R:R:F250	R:R:I138	5.02	Yes	No	1	9	8
103	R:R:F254	R:R:I138	16.33	Yes	No	1	9	8
104	R:R:L139	R:R:T142	2.95	No	No	0	5	8
105	R:R:L139	R:R:V174	2.98	No	No	0	5	7
106	R:R:C171	R:R:F140	2.79	No	Yes	5	7	7
107	R:R:F140	R:R:V174	5.24	Yes	No	0	7	7
108	R:R:F140	R:R:W175	4.01	Yes	No	0	7	9
109	R:R:I212	R:R:L141	2.85	Yes	Yes	1	7	8
110	R:R:F250	R:R:L141	4.87	Yes	Yes	1	9	8
111	R:R:D293	R:R:L141	8.14	Yes	Yes	1	9	8
112	R:R:L141	R:R:Y297	5.86	Yes	Yes	1	8	9
113	R:R:I212	R:R:T142	4.56	Yes	No	0	7	8
114	R:R:I144	R:R:R148	5.01	No	No	1	8	9
115	R:R:I144	R:R:Y297	7.25	No	Yes	1	8	9
116	R:R:F215	R:R:V146	6.55	No	No	0	7	6
117	R:R:R148	R:R:Y297	4.12	No	Yes	1	9	9
118	R:R:V153	R:R:Y149	5.05	No	Yes	6	7	8
119	R:R:R154	R:R:Y149	10.29	No	Yes	6	6	8
120	R:R:F215	R:R:Y149	20.63	No	Yes	0	7	8
121	R:R:R218	R:R:Y149	6.17	No	Yes	0	4	8
122	R:R:L150	R:R:R159	15.79	No	No	7	6	5
123	R:R:L150	R:R:R162	3.64	No	No	7	6	7
124	R:R:I152	R:R:L223	2.85	No	Yes	0	7	8
125	R:R:R154	R:R:V153	9.15	No	No	6	6	7
126	R:R:A222	R:R:V153	3.39	No	No	0	5	7
127	R:R:R159	R:R:R162	15.99	No	No	7	5	7
128	R:R:C166	R:R:R162	5.57	No	No	0	3	7
129	R:R:P164	R:R:Q163	6.32	No	No	0	3	6
130	R:R:A165	R:R:Q163	4.55	No	No	0	5	6
131	R:R:L203	R:R:V181	5.96	No	No	0	3	4
132	R:R:L183	R:R:T182	4.42	No	No	0	4	6
133	R:R:S184	R:R:V188	3.23	No	No	0	7	4
134	R:R:R196	R:R:V185	11.77	Yes	No	1	3	4
135	R:R:L200	R:R:V185	7.45	No	No	1	5	4
136	R:R:T189	R:R:V188	6.35	No	No	8	4	4
137	R:R:C195	R:R:V188	5.12	No	No	8	9	4
138	R:R:C195	R:R:T189	5.07	No	No	8	9	4
139	R:R:C195	R:R:G190	3.92	No	No	0	9	3
140	R:R:P193	R:R:S191	5.34	No	No	0	4	4
141	R:R:P193	R:R:R192	4.32	No	No	0	4	2
142	R:R:R192	R:R:V264	3.92	No	No	0	2	5
143	R:R:L200	R:R:R196	15.79	No	Yes	1	5	3
144	R:R:Q261	R:R:R196	5.84	Yes	Yes	1	6	3
145	R:R:F198	R:R:V202	5.24	No	No	0	4	4
146	R:R:F198	R:R:V262	5.24	No	No	0	4	5
147	R:R:H258	R:R:T201	6.85	Yes	No	0	8	5
148	R:R:Q261	R:R:T201	5.67	Yes	No	0	6	5
149	R:R:L206	R:R:V202	2.98	No	No	0	4	4
150	R:R:F205	R:R:T255	5.19	No	No	0	9	5
151	R:R:F205	R:R:H258	15.84	No	Yes	0	9	8
152	R:R:L206	R:R:L210	6.92	No	No	0	4	3
153	R:R:L207	R:R:P208	4.93	No	No	0	6	9
154	R:R:L207	R:R:V211	2.98	No	No	0	6	5
155	R:R:F250	R:R:L209	4.87	Yes	No	0	9	6
156	R:R:F250	R:R:I212	3.77	Yes	Yes	1	9	7
157	R:R:L243	R:R:T216	5.9	No	No	0	7	8
158	R:R:I219	R:R:L223	2.85	No	Yes	0	7	8
159	R:R:I219	R:R:L243	4.28	No	No	0	7	7
160	R:R:M220	R:R:M240	7.22	No	Yes	0	4	4
161	R:R:L223	R:R:R236	6.07	Yes	Yes	0	8	6
162	R:R:L223	R:R:M240	2.83	Yes	Yes	0	8	4
163	R:R:M240	R:R:S224	3.07	Yes	No	0	4	4
164	R:R:P226	R:R:R225	4.32	No	No	0	5	4
165	R:R:L228	R:R:R236	12.15	No	Yes	0	4	6
166	R:R:H230	R:R:R233	3.39	No	No	0	4	3
167	R:R:G232	R:R:R235	4.5	No	No	0	3	5
168	R:R:R233	R:R:R236	3.2	No	Yes	0	3	6
169	R:R:Q241	R:R:V237	4.3	No	No	0	5	5
170	R:R:L242	R:R:V300	8.94	No	No	0	7	6
171	R:R:V246	R:R:V296	3.21	No	No	0	8	7
172	R:R:V246	R:R:Y297	10.09	No	Yes	0	8	9
173	R:R:I249	R:R:M292	11.66	No	No	0	6	7
174	R:R:F250	R:R:F254	6.43	Yes	Yes	1	9	9
175	R:R:C253	R:R:F254	8.38	No	Yes	1	7	9
176	R:R:C253	R:R:N289	3.15	No	No	1	7	9
177	R:R:F254	R:R:S286	5.28	Yes	No	1	9	8
178	R:R:F254	R:R:N289	10.87	Yes	No	1	9	9
179	R:R:P256	R:R:T255	5.25	No	No	0	9	5
180	R:R:A282	R:R:P256	3.74	No	No	0	7	9
181	R:R:F257	R:R:H258	6.79	Yes	Yes	1	6	8
182	R:R:F257	R:R:R260	3.21	Yes	Yes	1	6	4
183	R:R:F257	R:R:Q261	8.2	Yes	Yes	1	6	6
184	R:R:F257	R:R:Y279	4.13	Yes	Yes	1	6	5
185	R:R:Q261	R:R:R260	8.18	Yes	Yes	1	6	4
186	R:R:R260	R:R:V264	5.23	Yes	No	0	4	5
187	R:R:R260	R:R:V278	5.23	Yes	No	0	4	4
188	R:R:R260	R:R:Y279	4.12	Yes	Yes	1	4	5
189	R:R:L266	R:R:V262	2.98	No	No	0	4	5
190	R:R:L266	R:R:W267	3.42	No	No	0	4	2
191	R:R:D269	R:R:W267	4.47	No	No	0	1	2
192	R:R:D269	R:R:M270	2.77	No	No	0	1	3
193	R:R:M270	R:R:T274	4.52	No	No	0	3	2
194	R:R:H273	R:R:P271	12.2	No	No	0	3	2
195	R:R:P271	R:R:T274	5.25	No	No	0	2	2
196	R:R:H272	R:R:H273	8.36	No	No	0	3	3
197	R:R:H272	R:R:L276	3.86	No	Yes	1	3	4
198	R:R:H280	R:R:Y279	7.62	No	Yes	1	5	5
199	R:R:V283	R:R:Y279	6.31	No	Yes	1	5	5
200	R:R:T284	R:R:V281	3.17	No	No	0	5	5
201	R:R:L285	R:R:L288	2.77	No	No	0	7	5
202	R:R:D293	R:R:N289	13.46	Yes	No	1	9	9
203	R:R:D293	R:R:Y297	6.9	Yes	Yes	1	9	9
204	R:R:F299	R:R:I295	8.79	Yes	No	3	7	6
205	R:R:C298	R:R:F299	5.59	Yes	Yes	3	7	7
206	R:R:C298	R:R:F304	9.78	Yes	Yes	3	7	8
207	R:R:F299	R:R:F304	8.57	Yes	Yes	3	7	8
208	R:R:G303	R:R:S302	3.71	No	No	0	6	6
209	R:R:F304	R:R:V308	10.49	Yes	No	0	8	4
210	R:R:H126	R:R:T108	2.74	Yes	No	0	6	6
211	R:R:L229	R:R:Q231	2.66	No	No	0	2	4
212	R:R:R81	R:R:V77	2.62	No	No	0	6	6
213	R:R:F124	R:R:V127	2.62	Yes	No	0	4	4
214	R:R:R192	R:R:V197	2.62	No	No	0	2	5
215	R:R:F215	R:R:V214	2.62	No	No	0	7	4
216	R:R:F304	R:R:T301	2.59	Yes	No	0	8	7
217	R:R:V170	R:R:Y91	2.52	No	Yes	0	5	7
218	R:R:K85	R:R:R168	2.48	No	No	0	5	4
219	R:R:F124	R:R:L186	2.44	Yes	No	0	4	4
220	R:R:L228	R:R:R225	2.43	No	No	0	4	4
221	R:R:I219	R:R:Y149	2.42	No	Yes	0	7	8
222	R:R:G51	R:R:P50	2.03	No	No	0	3	5
223	R:R:A66	R:R:G67	1.95	No	No	0	5	8
224	R:R:G67	R:R:S290	1.86	No	No	0	8	8
225	R:R:G190	R:R:S191	1.86	No	No	0	3	4
226	R:R:G103	R:R:V102	1.84	No	Yes	0	5	6
227	R:R:G129	R:R:V102	1.84	No	Yes	0	6	6
228	R:R:C79	R:R:C80	1.82	No	No	0	2	4
229	R:R:C119	R:R:C122	1.82	No	No	0	3	9
230	R:R:G303	R:R:T301	1.82	No	No	0	6	7
231	R:R:A178	R:R:C136	1.81	No	No	0	7	6
232	R:R:G217	R:R:M220	1.75	No	No	0	2	4
233	R:R:G187	R:R:L186	1.71	No	No	0	2	4
234	R:R:G310	R:R:L311	1.71	No	No	0	5	4
235	R:R:A116	R:R:V112	1.7	No	No	0	4	5
236	R:R:A265	R:R:V197	1.7	No	No	0	4	5
237	R:R:I90	R:R:P164	1.69	No	No	0	7	3
238	R:R:C145	R:R:T216	1.69	No	No	0	9	8
239	R:R:C145	R:R:I212	1.64	No	Yes	0	9	7
240	R:R:E156	R:R:G157	1.64	No	No	0	5	5
241	R:R:C253	R:R:I249	1.64	No	No	0	7	6
242	R:R:L285	R:R:P256	1.64	No	No	0	7	9
243	R:R:A167	R:R:I90	1.62	No	No	0	8	7
244	R:R:S275	R:R:V264	1.62	No	No	0	4	5
245	R:R:C291	R:R:M292	1.62	No	No	0	6	7
246	R:R:A263	R:R:M270	1.61	No	No	0	5	3
247	R:R:D293	R:R:P294	1.61	Yes	No	1	9	9
248	R:R:S137	R:R:T98	1.6	No	No	0	9	8
249	R:R:S105	R:R:T108	1.6	No	No	0	6	6
250	R:R:V181	R:R:V185	1.6	No	No	0	4	4
251	R:R:V277	R:R:V281	1.6	No	No	0	2	5
252	R:R:V296	R:R:V300	1.6	No	No	0	7	6
253	R:R:G47	R:R:H46	1.59	No	No	0	2	4
254	R:R:T284	R:R:V59	1.59	No	No	0	5	5
255	R:R:G61	R:R:H60	1.59	No	No	0	5	8
256	R:R:T307	R:R:V77	1.59	No	No	0	5	6
257	R:R:T245	R:R:V296	1.59	No	No	0	4	7
258	R:R:A239	R:R:L223	1.58	No	Yes	0	7	8
259	R:R:I93	R:R:V97	1.54	Yes	No	0	5	5
260	R:R:C166	R:R:Q163	1.53	No	No	0	3	6
261	R:R:M240	R:R:V237	1.52	Yes	No	0	4	5
262	R:R:L104	R:R:S105	1.5	No	No	0	5	6
263	R:R:L247	R:R:S213	1.5	No	No	0	7	4
264	R:R:G232	R:R:R236	1.5	No	Yes	0	3	6
265	R:R:G310	R:R:R309	1.5	No	No	0	5	5
266	R:R:L70	R:R:V69	1.49	No	No	0	6	4
267	R:R:L311	R:R:T307	1.47	No	No	0	4	5
268	R:R:G115	R:R:Y114	1.45	No	No	0	4	2
269	R:R:F49	R:R:P50	1.44	Yes	No	0	3	5
270	R:R:P155	R:R:R154	1.44	No	No	0	8	6
271	R:R:I212	R:R:L247	1.43	Yes	No	0	7	7
272	R:R:L244	R:R:M220	1.41	No	No	0	4	4
273	R:R:A199	R:R:R196	1.38	No	Yes	0	4	3
274	R:R:L209	R:R:L251	1.38	No	No	0	6	5
275	R:R:F173	R:R:V170	1.31	No	No	0	3	5
276	R:R:F173	R:R:V174	1.31	No	No	0	3	7
277	R:R:R238	R:R:V300	1.31	No	No	0	7	6
278	R:R:Q234	R:R:R235	1.17	No	No	0	3	5
279	R:R:F304	R:R:Q305	1.17	Yes	No	0	8	8
280	R:R:H36	R:R:R40	1.13	No	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F35	9.18	5	2	5
2	R:R:L45	5.7475	4	1	4
3	R:R:F49	4.435	4	0	3
4	R:R:W53	7.534	5	1	2
5	R:R:L56	5.71	4	1	6
6	R:R:F78	6.2925	4	3	6
7	R:R:Y91	4.844	5	0	7
8	R:R:I93	3.7325	4	0	5
9	R:R:V102	3.5175	4	0	6
10	R:R:F124	3.565	4	0	4
11	R:R:H126	6.21667	6	2	6
12	R:R:M134	6.2975	4	1	7
13	R:R:F140	7.54	4	5	7
14	R:R:L141	5.43	4	1	8
15	R:R:Y149	8.912	5	6	8
16	R:R:R196	8.414	5	1	3
17	R:R:I212	2.85	5	1	7
18	R:R:L223	3.236	5	0	8
19	R:R:R236	5.73	4	0	6
20	R:R:M240	3.66	4	0	4
21	R:R:F250	4.992	5	1	9
22	R:R:F254	9.458	5	1	9
23	R:R:F257	6.954	5	1	6
24	R:R:H258	8.355	4	1	8
25	R:R:R260	5.194	5	1	4
26	R:R:Q261	6.9725	4	1	6
27	R:R:L276	3.91	4	1	4
28	R:R:Y279	5.84286	7	1	5
29	R:R:D293	7.108	5	1	9
30	R:R:Y297	6.844	5	1	9
31	R:R:C298	7.19	4	3	7
32	R:R:F299	7.26	4	3	7
33	R:R:F304	7.07429	7	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H126	R:R:R109	27.9028	6.77	Yes	No	0	6	6
2	R:R:R109	R:R:Y130	29.2348	4.12	No	No	0	6	6
3	R:R:Y130	R:R:Y279	30.576	6.95	No	Yes	1	6	5
4	R:R:H46	R:R:W53	14.9917	3.17	No	Yes	0	4	2
5	R:R:L45	R:R:W53	11.9833	5.69	Yes	Yes	1	4	2
6	R:R:H280	R:R:L45	43.4044	9	No	Yes	1	5	4
7	R:R:H280	R:R:Y279	73.8793	7.62	No	Yes	1	5	5
8	R:R:L56	R:R:W53	11.6067	6.83	Yes	Yes	1	6	2
9	R:R:H280	R:R:L56	29.2945	7.71	No	Yes	1	5	6
10	R:R:L276	R:R:L45	31.9998	4.15	Yes	Yes	1	4	4
11	R:R:L52	R:R:L56	17.4444	4.15	No	Yes	0	3	6
12	R:R:H272	R:R:L276	21.151	3.86	No	Yes	1	3	4
13	R:R:D293	R:R:P294	10.5365	1.61	Yes	No	1	9	9
14	R:R:D293	R:R:N289	40.079	13.46	Yes	No	1	9	9
15	R:R:F254	R:R:N289	39.1007	10.87	Yes	No	1	9	9
16	R:R:F254	R:R:S286	100	5.28	Yes	No	1	9	8
17	R:R:M134	R:R:S286	88.646	4.6	Yes	No	1	7	8
18	R:R:F257	R:R:M134	88.3015	12.44	Yes	Yes	1	6	7
19	R:R:F257	R:R:Q261	14.661	8.2	Yes	Yes	1	6	6
20	R:R:Q261	R:R:R196	22.2717	5.84	Yes	Yes	1	6	3
21	R:R:F257	R:R:Y279	79.7308	4.13	Yes	Yes	1	6	5
22	R:R:G103	R:R:L106	10.0037	5.13	No	No	0	5	8
23	R:R:G103	R:R:V102	11.4137	1.84	No	Yes	0	5	6
24	R:R:N133	R:R:V102	16.9622	4.43	No	Yes	0	8	6
25	R:R:F78	R:R:I93	39.3717	3.77	Yes	Yes	0	6	5
26	R:R:I93	R:R:V89	46.8767	3.07	Yes	No	0	5	7
27	R:R:T86	R:R:V89	48.3787	3.17	No	No	0	7	7
28	R:R:P87	R:R:T86	49.8714	3.5	No	No	0	6	7
29	R:R:A167	R:R:P87	51.3549	3.74	No	No	0	8	6
30	R:R:A167	R:R:Y91	66.7463	4	No	Yes	0	8	7
31	R:R:I144	R:R:Y91	68.7121	4.84	No	Yes	0	8	7
32	R:R:I144	R:R:Y297	69.5067	7.25	No	Yes	1	8	9
33	R:R:L141	R:R:Y297	43.4962	5.86	Yes	Yes	1	8	9
34	R:R:F250	R:R:L141	34.4709	4.87	Yes	Yes	1	9	8
35	R:R:F250	R:R:F254	58.047	6.43	Yes	Yes	1	9	9
36	R:R:F304	R:R:F78	26.456	6.43	Yes	Yes	3	8	6
37	R:R:D293	R:R:Y297	35.8442	6.9	Yes	Yes	1	9	9
38	R:R:F140	R:R:V174	10.3482	5.24	Yes	No	0	7	7
39	R:R:F140	R:R:W175	12.0843	4.01	Yes	No	0	7	9
40	R:R:F131	R:R:W175	15.2995	4.01	No	No	0	5	9
41	R:R:F131	R:R:T182	16.7049	14.27	No	No	0	5	6
42	R:R:H135	R:R:T182	18.1839	13.69	No	No	0	8	6
43	R:R:H135	R:R:L200	19.9706	5.14	No	No	0	8	5
44	R:R:L200	R:R:R196	20.4253	15.79	No	Yes	1	5	3
45	R:R:F304	R:R:V77	10.3344	10.49	Yes	No	0	8	6
46	R:R:A167	R:R:I90	17.0494	1.62	No	No	0	8	7
47	R:R:F250	R:R:I212	25.5971	3.77	Yes	Yes	1	9	7
48	R:R:I219	R:R:Y149	10.4538	2.42	No	Yes	0	7	8
49	R:R:I219	R:R:L243	30.5714	4.28	No	No	0	7	7
50	R:R:L243	R:R:T216	31.5267	5.9	No	No	0	7	8
51	R:R:C145	R:R:T216	32.4499	1.69	No	No	0	9	8
52	R:R:C145	R:R:I212	33.364	1.64	No	Yes	0	9	7
53	R:R:P164	R:R:Q163	10.2563	6.32	No	No	0	3	6
54	R:R:I90	R:R:P164	11.9695	1.69	No	No	0	7	3
55	R:R:I219	R:R:L223	20.7422	2.85	No	Yes	0	7	8
56	R:R:R260	R:R:Y279	12.5896	4.12	Yes	Yes	1	4	5
57	R:R:R260	R:R:V264	16.7922	5.23	Yes	No	0	4	5
58	R:R:R192	R:R:V264	14.1879	3.92	No	No	0	2	5
59	R:R:P193	R:R:R192	10.0266	4.32	No	No	0	4	2
60	R:R:D269	R:R:W267	10.8626	4.47	No	No	0	1	2
61	R:R:D269	R:R:M270	12.3783	2.77	No	No	0	1	3
62	R:R:M270	R:R:T274	15.3821	4.52	No	No	0	3	2
63	R:R:P271	R:R:T274	16.8703	5.25	No	No	0	2	2
64	R:R:H273	R:R:P271	18.3493	12.2	No	No	0	3	2
65	R:R:H272	R:R:H273	19.819	8.36	No	No	0	3	3
66	R:R:L223	R:R:R236	10.1966	6.07	Yes	Yes	0	8	6
67	R:R:V246	R:R:Y297	10.7523	10.09	No	Yes	0	8	9
68	R:R:N133	R:R:S286	11.0922	7.45	No	No	1	8	8
69	R:R:I212	R:R:L141	12.7503	2.85	Yes	Yes	1	7	8
70	R:R:F257	R:R:R260	12.709	3.21	Yes	Yes	1	6	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HS3_nogp

PDB Summary
PDB	8HS3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	251
Number of Links	280
Number of Hubs	33
Number of Links mediated by Hubs	123
Number of Communities	8
Number of Nodes involved in Communities	63
Number of Links involved in Communities	83

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	43054
Length Of Smallest Path	3
Average Path Length	14.8689
Length of Longest Path	38
Minimum Path Strength	1.31
Average Path Strength	5.76164
Maximum Path Strength	15.46
Minimum Path Correlation	0.7
Average Path Correlation	0.925672
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	43.2594
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6231
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • electron transport chain • metabolic process • generation of precursor metabolites and energy • receptor complex • periplasmic space • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99678
Sequence	>8HS3_nogp_Chain_R V P L F H L F A R L D E E L H G T F P G L W L A L M A V H G A I F L A G L V L N G L A L Y V F C C R T A K T P S V I Y T I N L V V T D L L V G L S L P T R F A V Y Y G A R G C L R C A F P H V L G Y F L N M H C S I L F L T C I C V D R Y L A I V R P E G S R R C R Q P A C A R A V C A F V W L A A G A V T L S V L G V T G S R P C C R V F A L T V L E F L L P L L V I S V F T G R I M C A L S R P G L L H Q G R Q R R V R A M Q L L L T V L I I F L V C F T P F H A R Q V A V A L W P D M P H H T S L V V Y H V A V T L S S L N S C M D P I V Y C F V T S G F Q A T V R G L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HS2	A	Orphan	Orphan	GPR20	Homo sapiens	Fab046	-	-	3.08	2023-03-08	10.1038/s41421-023-00520-8
	8HSC	A	Orphan	Orphan	GPR20	Homo sapiens	Fab046	-	Gi1/β1/γ2	3.22	2023-03-08	10.1038/s41421-023-00520-8
	8HSC (No Gprot)	A	Orphan	Orphan	GPR20	Homo sapiens	Fab046	-		3.22	2023-03-08	10.1038/s41421-023-00520-8
	8HS3	A	Orphan	Orphan	GPR20	Homo sapiens	-	-	Gi1/β1/γ2	3.14	2023-03-08	10.1038/s41421-023-00520-8
	8HS3 (No Gprot)	A	Orphan	Orphan	GPR20	Homo sapiens	-	-		3.14	2023-03-08	10.1038/s41421-023-00520-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HS3_nogp.zip

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