Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.01 3.8275407
2G.S1.02 5.26333636
3G.S1.06 5.9675438
4G.S1.07 3.2475418
5G.s1h1.05 3.215439
6G.H1.01 5.59333639
7G.H1.08 3.4775439
8G.S2.06 5.728539
9G.S2.08 6.02536
10G.S3.01 4.118535
11G.S3.03 6.04638
12G.S3.05 4.285408
13G.s3h2.03 5.316519
14G.H2.05 6.405418
15G.H2.06 5.53857719
16G.H2.07 5.61833619
17G.H2.10 6.4375418
18G.h2s4.01 8.862519
19G.S4.03 3.096537
20G.S4.04 4.998519
21G.S4.05 4.428537
22G.H3.06 5.75406
23G.H3.09 5.55833619
24G.H3.13 10.606516
25G.H3.17 8.866515
26G.S5.03 5.6375439
27G.S5.04 5.5675419
28G.S5.05 4.835639
29G.S5.07 5.816539
30G.HG.01 6.825416
31G.HG.03 3.8975436
32G.HG.04 3.2475418
33G.HG.15 8.3417
34G.hgh4.02 5.39518
35G.hgh4.04 4.46516
36G.hgh4.05 11.13516
37G.hgh4.08 6.00833616
38G.hgh4.11 4.8625415
39G.hgh4.20 10.6675413
40G.hgh4.21 7.48414
41G.H4.03 3.78833614
42G.H4.07 8.702515
43G.H4.08 7.77513
44G.H4.10 9.71667617
45G.H4.12 6.918514
46G.H4.14 8.1125415
47G.H4.15 7.682518
48G.h4s6.02 4.144517
49G.h4s6.08 4.235415
50G.h4s6.20 12.19754124
51G.S6.01 3.7825415
52G.S6.02 7.348336128
53G.S6.05 9.81515
54G.s6h5.01 6.8125439
55G.H5.04 3.545438
56G.H5.05 6.2975435
57G.H5.06 8.506534
58G.H5.08 6.69333638
59G.H5.15 4.57286738
60G.H5.17 13.52254125
61G.H5.19 4.3538
62G.H5.23 5.345404
63b.1x4 3.765408
64b.h2x1 3.975405
65b.h2x4 3.095443
66b.h2x5 4.488545
67b.lhb1x3 4.232542
68b.lhb1x6 4.852543
69b.lhb1x9 3.4075443
70b.lhb1x11 4.02544
71b.b1x6 8.915459
72b.l1x3 7.79429759
73b.l1x6 11.234519
74b.b2x1 6.88518
75b.b2x3 4.658556
76b.b2x5 6.66167657
77b.b3x2 4.885455
78b.b3x3 4.7175498
79b.l3x1 9.5275419
80b.l3x2 6.738559
81b.b4x2 4.07833658
82b.b4x3 5.5425497
83b.b4x5 4.666597
84b.b4x6 10.4014759
85b.b4x7 9.335458
86b.l4x3 6.4775456
87b.b5x3 6.17143759
88b.b5x7 5.925497
89b.l5x1 4.918598
90b.l5x5 7.08143719
91b.b6x1 5.698519
92b.b6x5 4.69875896
93b.l6x5 7.61414
94b.b7x1 7.2775414
95b.b7x2 4.02833698
96b.b7x4 4.7075498
97b.b8x1 4.135418
98b.b8x3 3.98516
99b.b8x4 5.51714796
100b.l8x1 3.8125495
101b.l8x8 3.9475494
102b.b9x4 7.8525409
103b.l9x3 7.21719
104b.l9x6 5.8225818
105b.l9x7 3.9175417
106b.b10x5 5.26167619
107b.l10x1 4.1375483
108b.b11x2 5.41417
109b.b11x3 4.575405
110b.b11x4 5.785419
111b.l11x2 9.425419
112b.b12x3 4.235488
113b.b12x5 5.395486
114b.b12x6 8.72857718
115b.l12x1 3.8325416
116b.b13x3 8.3925414
117b.b13x7 8.574587
118b.l13x3 8.96167689
119b.l13x6 6.705419
120b.l13x7 4.766589
121b.b15x1 8.314589
122b.b15x2 6.5425476
123b.b15x3 5.2625489
124b.l15x1 5.225617
125b.l15x2 7.6475489
126b.b16x4 11.9486
127b.b16x5 4.8425405
128b.b16x6 10.194588
129b.b17x5 7.6725477
130b.l17x3 10.5583679
131b.l17x6 7.886519
132b.b18x3 5.09478
133b.b18x5 5.4275405
134b.l18x1 6.25333616
135b.l18x2 6.015417
136b.l18x3 7.01415
137b.b19x2 7.19676
138b.b19x4 5.236578
139b.l19x1 6.85419
140b.l19x2 9.408579
141b.b20x2 7.082576
142b.b20x4 8.84678
143b.b20x6 7.866576
144b.b21x1 10.6175477
145b.b21x2 3.4475406
146b.b21x5 6.0825414
147b.b21x7 6.28615
148b.l21x5 3.285414
149b.b22x5 6.114517
150b.l22x5 6.34857749
151b.b23x1 4.088545
152b.b23x2 4.79416
153b.b23x3 3.635447
154b.b23x6 7.56714717
155b.l23x1 5.578516
156b.b24x3 3.752545
157b.b24x4 8.736516
158b.b24x6 7.74418
159b.l24x2 6.665446
160b.l24x3 6.8575405
161b.l25x3 9.102549
162b.l25x6 12.026518
163b.b26x3 3.576546
164b.l26x1 7.375457
165b.b27x1 3.336546
166b.b27x3 5.4175448
167b.l27x1 10.6114719
168b.l27x2 7.324549
169b.b28x3 5.65557
170b.b28x4 6.958546
171b.b28x6 11.312549
172g.h1x11 4.5854149
173g.h1x15 2.355408
174g.l1x4 6.8175478
175g.ctx3 5.56667609
176g.ctx6 3.8546
177g.ctx14 4.771676109
178g.ctx16 4.911258108
179Lig 10.42862120
1801x35 6.505424
1811x39 11.4925427
1821x43 5.345425
1831x46 4.4925408
1841x50 5.8025409
1851x53 4.6585119
1861x57 3.825117
187I1x50 5.0445118
1882x40 5.6925409
1892x42 4.62167608
1902x46 4.808569
1912x49 4.3225468
1922x50 5.78833669
1932x51 4.6125407
1942x57 5.93527
1952x60 6.51427
1962x63 4.2575425
1972x65 4.54425
198E1x50 7.24667628
199E1x52 7.328526
2003x29 4.3525426
2013x32 4.85427
2023x38 7.8225468
2033x42 4.615668
2043x43 3.6525468
2053x47 4.7375469
2063x49 7.88439
2073x50 6.022569
208I2x50 4.9925438
209I2x51 4.724537
210I2x54 7.3175436
211I2x56 6.06535
212I2x57 9.525437
2134x41 5.9975437
2144x50 7.67409
2154x57 3.69408
2164x61 8.642527
2174x64 7.63425
218E2 15.5851423
219E2x52 5.95429725
2205x36 5.6475425
2215x39 6.635628
2225x40 6.284526
2235x47 6.84408
2245x54 5.7468
2255x58 7.20333669
2265x65 3.4165139
2276x40 5.395469
2286x45 3.9475406
2296x48 6.72833628
2306x51 3.44507
2316x52 5.28527
232E3 14.5629723
2337x32 3.385423
2347x42 8.38667627
2357x49 5.9275469
2367x53 5.2425869
2377x55 3.345116
2388x48 6.5225406
2398x50 6.054297119
2408x58 3.9654156
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b10x1 b.b11x5 10.25954.89NoNo096
2b.b10x1 b.l9x6 10.38512.54NoYes098
3G.H2.07 b.l9x6 19.02683.86YesYes198
4G.H2.07 G.h2s4.01 17.74194.01YesYes199
5G.S1.05 G.h2s4.01 41.497723.14NoYes199
6G.S1.05 G.S1.07 41.574.15NoYes198
7G.S1.07 G.s1h1.01 99.94191.71YesNo089
8G.H1.01 G.s1h1.01 1003.49YesNo099
9G.H1.01 G.S1.06 97.67047.05YesYes398
10G.S1.06 G.S3.05 48.99389.9YesYes088
11G.S1.04 G.S3.05 48.47712.83NoYes078
12G.S1.04 G.S3.03 98.43484.87NoYes078
13G.S1.02 G.S3.03 98.42933.39YesYes368
14G.S1.02 I2x54 48.41366.77YesYes366
15G.S1.06 G.S4.03 48.8382.85YesYes387
16G.S1.04 G.S4.03 50.00532.85NoYes077
17G.H5.15 G.S1.02 49.79295.3YesYes386
18b.b26x2 b.b2x3 19.57944.86NoYes076
19b.b26x1 b.b26x2 20.19163.44NoNo097
20b.b26x1 b.l27x1 20.5024.94NoYes099
21G.H3.17 b.l27x1 10.20059.37YesYes159
22G.H3.15 G.H3.17 43.03323.39NoYes085
23G.H3.15 G.H3.18 43.1310.98NoNo089
24G.H3.18 G.h3s5.03 40.85372.95NoNo097
25G.S4.02 G.h3s5.03 40.93583.04NoNo087
26b.l3x1 b.l5x5 18.2885.48YesYes199
27b.b2x1 b.l27x1 12.72585.79YesYes189
28G.H3.09 G.S4.04 12.9097.5YesYes199
29G.S4.04 G.S5.04 11.10313.65YesYes199
30G.H3.06 G.H4.14 11.14463.98YesYes065
31G.H3.06 G.H4.15 11.69312.18YesYes068
32G.H3.17 b.l23x1 27.98177.82YesYes156
33G.H5.15 G.H5.19 48.65085.3YesYes388
343x53 G.H5.19 85.12425.85NoYes088
353x53 G.H5.23 80.17842.67NoYes084
36G.H5.19 I2x54 48.29544.51YesYes386
37G.H5.19 I2x53 11.79112.79YesNo388
383x50 G.H5.23 73.26558.23YesYes094
39b.b20x7 b.b21x4 14.8136.79NoNo095
40b.b20x7 b.l20x3 13.46184.63NoNo097
41b.b21x2 b.l20x3 13.30853.03YesNo067
42b.1x19 b.b21x2 12.69443.5NoYes066
43b.l21x7 b.l23x1 21.50633.11NoYes156
44b.b23x6 b.l21x7 21.21694.03YesNo175
45b.b23x6 b.b24x6 19.25275.79YesYes178
46b.b21x7 b.b24x6 19.09199.65YesYes158
47b.b20x5 b.b21x4 12.98692.77NoNo075
48b.b22x2 b.b26x3 16.56836.01NoYes086
49b.b22x1 b.b22x2 16.81153.2NoNo088
503x50 5x58 55.38868.23YesYes699
515x54 5x58 36.65653.59YesYes689
525x54 6x44 37.07838.71YesNo089
536x44 6x48 36.10397.02NoYes098
543x36 6x48 14.5267.36NoYes278
553x36 Lig 14.3625.24NoYes270
566x48 6x52 16.41256.01YesYes287
576x52 Lig 28.5033.22YesYes270
585x58 6x41 18.14153.79YesNo098
596x41 6x45 17.96972.62NoYes086
605x47 6x45 17.46726.43YesYes086
615x47 6x52 16.15618.57YesYes087
62E2 Lig 10.235715.6YesYes230
633x50 7x53 17.36236.17YesYes699
642x42 3x49 14.18748.16YesYes089
652x42 4x46 10.64025.02YesNo087
66G.h2s4.01 b.l5x5 21.886912.03YesYes199
67G.S1.07 G.S4.02 41.01054.28YesNo188
68G.H3.12 G.S1.07 22.99982.85NoYes188
69b.b20x5 b.b21x7 13.11255.86NoYes075
70G.H3.12 G.S4.04 22.69342.51NoYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2Lig15.62YesYes3010
2x63Lig3.532YesYes5010
2x67Lig8.090NoYes4010
E1x50Lig4.242YesYes8010
E2x50Lig7.622NoYes9010
E2x51Lig15.822NoYes4010
E3Lig28.72YesYes3010
6x58Lig9.692NoYes4010
6x55Lig7.512NoYes7010
7x34Lig19.972NoYes5010
2x60Lig7.012YesYes7010
3x29Lig3.012YesYes6010
3x32Lig2.682YesYes7010
4x61Lig15.52YesYes7010
E2x52Lig4.782YesYes5010
5x40Lig7.562YesYes6010
3x33Lig3.012NoYes6010
3x36Lig5.242NoYes7010
6x52Lig3.222YesYes7010
2x563x328.10NoYes7721
2x567x4214.790NoYes7722
2x603x325.612YesYes7711
2x607x384.122YesNo7612
2x607x429.32YesYes7712
2x622x633.390NoYes5521
2x63E1x507.222YesYes5811
2x63E1x522.892YesYes5612
E1x49E27.532NoYes4321
E1x50E1x5211.792YesYes8612
3x25E1x504.192NoYes9821
E1x50E24.872YesYes8311
E1x50E2x5011.172YesNo8911
3x223x263.062NoNo4522
3x22E24.492NoYes4321
3x25E23.172NoYes9321
3x25E2x507.282NoNo9921
3x264x653.062NoNo5622
3x26E25.62NoYes5321
3x293x323.012YesYes6711
3x294x614.992YesYes6711
3x294x656.42YesNo6612
3x334x575.242NoYes6812
3x366x487.362NoYes7812
4x574x613.590YesYes8721
4x61E2x5212.382YesYes7511
4x615x396.752YesYes7812
4x64E2x523.092YesYes5521
4x64E213.772YesYes5321
4x65E2x522.640NoYes6521
E2E263.552YesYes3311
E2E2x5118.782YesNo3411
E2E2x526.092YesYes3511
5x36E2x524.682YesYes5521
5x39E2x528.022YesYes8521
5x35E22.832NoYes4321
5x36E26.652YesYes5321
5x365x408.652YesYes5621
5x395x403.172YesYes8621
5x406x557.652YesNo6711
5x406x594.392YesNo6612
5x4616x526.090NoYes7721
5x476x528.570YesYes8721
6x486x526.012YesYes8721
6x516x522.510YesYes7721
6x516x552.830YesNo7721
6x517x372.940YesNo7622
6x517x384.280YesNo7622
6x576x614.472NoNo5422
6x57E320.012NoYes5321
6x58E313.142NoYes4311
6x61E38.832NoYes4321
E3E314.842YesYes3311
7x347x372.942NoNo5612
7x387x4210.552NoYes6722
7x317x341.760NoNo3521
3x21E21.710NoYes7321
6x54E31.580NoYes5321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
90.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
77.27Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
76.19Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
71.43Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
70.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
70.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
70.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
70.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
70.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
66.67Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
65.22Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
64.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
61.90Consensuscck_onOrthosteric Ligandccka_on cckb_on
61.90Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
60.87Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
60.87Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
60.87Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
60.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
60.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
59.09Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
58.33Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
57.69Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
56.52Single7F8XNN90567F8X-CCKA-NN9056
56.52Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
56.52Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
56.52Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
56.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
54.17Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
53.85Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
53.57Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
52.17Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
52.00Single6PT2KGCHM076PT2-δ-KGCHM07
52.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
52.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
51.85Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
51.85Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
50.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
50.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
50.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
50.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
50.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
48.39Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
48.00Single3QAKUK-4320973QAK-A2A-UK-432097
48.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
48.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
48.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
47.83Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
47.83Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
47.62Single8QOTNanobody-E8QOT-μ-Nanobody-E
46.88Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
46.67Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
46.67Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
46.67Consensusbombesin_onOrthosteric Ligandbb2_on
46.67Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
46.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
46.67Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
46.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
46.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
46.43Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
46.15Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
45.83Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
45.83Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
45.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
45.83Single8QJ2pN1628QJ2-MC4-pN162-Gs
45.45Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
45.45Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
45.45Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
45.45Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
44.83Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
44.83Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
44.44Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
44.44Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
44.44Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
44.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
44.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
44.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
43.48Single4RWADIPP-NH24RWA-δ-DIPP-NH2
43.48Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
43.48Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
43.48Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
43.48Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
42.86Single5DHGC-355DHG-NOP-C-35
42.86Single5DHHSB-6121115DHH-NOP-SB-612111
42.86Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.86Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
42.86Single8ZRTET-18ZRT-ETB-ET-1
42.86Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
42.86Consensuscck_offOrthosteric Ligandccka_off
42.86Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
42.86Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
42.86Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
42.31Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
42.31Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
42.31Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
42.31Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
41.94Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
41.67Single7EZCUKA7EZC-A2A-UKA
41.67Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
41.67Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
41.67Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.38Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
40.91Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
40.91Single5N2SPSB365N2S-A1-PSB36
40.91Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
40.91Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
40.91Single8GNEKW-63568GNE-A2A-KW-6356-Na
40.91Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
40.91Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
40.74Single5WF5UK-4320975WF5-A2A-UK-432097
40.74Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
40.74Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
40.74Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.74Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
40.74Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.74Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
40.74Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
40.74Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
40.74Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
40.62Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
40.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
40.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
40.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
40.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
40.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
40.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
40.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.29Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
39.29Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
39.29Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
39.13Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
39.13Single6J20Aprepitant6J20-NK1-Aprepitant
39.13Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
39.13Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
39.13Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
39.13Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.13Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
39.13Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
38.71Single6IGLIRL16206IGL-ETB-IRL1620
38.71Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
38.71Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
38.46Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
38.46Single4XT1Fractalkine4XT1-US28-Fractalkine
38.46Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
38.46Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
38.46Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
38.46Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
38.46Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
38.46Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
38.46Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.46Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.46Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single6IQLL7458706IQL-D4-L745870
38.10Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
38.10Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
38.10Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
38.10Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
38.10Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
38.10Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
38.10Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
37.93Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
37.93Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.93Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
37.93Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
37.93Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
37.93Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Single6MXTSalmeterol6MXT-β2-Salmeterol
37.50Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
37.50Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
37.50Single7YITNalfurafine7YIT-κ-Nalfurafine
37.50Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
37.50Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
37.50Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
37.50Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
37.50Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
37.50Single8JJLOlodaterol8JJL-β2-Olodaterol
37.50Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
37.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
37.50Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
37.50Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
37.50Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
37.50Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
37.50Consensusorexin_onOrthosteric Ligandox2_on
37.04Single7SK5CXCL127SK5-ACKR3-CXCL12
37.04Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
37.04Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
37.04Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
37.04Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
37.04Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
37.04Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.04Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
37.04Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
36.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
36.67Single7SK3CXCL127SK3-ACKR3-CXCL12
36.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
36.67Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
36.67Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
36.67Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
36.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
36.67Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
36.36Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
36.36Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
36.36Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
36.36Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.36Single8CU6LJ-45178CU6-A2A-LJ-4517
36.36Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
36.36Consensusa3_onOrthosteric Liganda3a_on
36.36Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
36.36Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
36.36Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.36Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.36Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
36.36Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
36.36Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
36.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
36.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
36.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
36.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
36.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
36.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
36.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
36.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
35.71Single3OE0CVX153OE0-CXCR4-CVX15
35.71Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
35.71Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
35.71Consensusangiotensin_onOrthosteric Ligandat1_on
35.71Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
35.71Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
35.71Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
35.71Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
35.48Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
35.00Single3OE9IT1t3OE9-CXCR4-IT1t
35.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
35.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
34.78Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
34.78Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
34.78Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
34.78Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
34.78Single7C61Ergotamine7C61-5-HT1B-Ergotamine
34.78Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
34.78Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
34.78Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
34.78Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
34.78Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
34.78Single8JXSPF-61428JXS-D1-PF-6142
34.78Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
34.78Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusa3_on_gpOrthosteric Liganda3a_on_gp
34.78Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
34.78Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
34.78Consensusadenosine_offOrthosteric Liganda1_off a2_off
34.78Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
34.62Single3NY9ICI118-5513NY9-β2-ICI118-551
34.62Single4UG2CGS216804UG2-A2A-CGS21680
34.62Single5WF6UK-4320975WF6-A2A-UK-432097
34.62Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
34.62Single7XN9L-054,5227XN9-SST2-L-054,522
34.62Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
34.62Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
34.62Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
34.62Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
34.62Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
34.62Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.48Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
34.48Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
34.48Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
34.48Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.48Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.48Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
34.48Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
34.38Single8IY6Endothelin-18IY6-ETB-Endothelin-1
34.38Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
34.38Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
33.33Single3ODUIT1t3ODU-CXCR4-IT1t
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
33.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
33.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
33.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
33.33Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
33.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
33.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
33.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
33.33Single6E59L-7607356E59-NK1-L-760735
33.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
33.33Single6J21Aprepitant6J21-NK1-Aprepitant
33.33Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
33.33Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
33.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
33.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
33.33Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
33.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
33.33Single7F8ULintitript7F8U-CCKA-Lintitript
33.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
33.33Single7PX4PSB-21137PX4-A2A-PSB-2113
33.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
33.33Single7TUYGSK682753A7TUY-GPR183-GSK682753A
33.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
33.33Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
33.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
33.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
33.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
33.33Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
33.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
33.33Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
33.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
33.33Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
33.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
33.33Single8WDTphotoNECA8WDT-A2A-photoNECA
33.33Single8WKYPG-9348WKY-MC4-PG-934
33.33Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
33.33Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
33.33Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
33.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
33.33Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
33.33Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
33.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
33.33Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
33.33Consensusrelaxin_onOrthosteric Ligandrxfp4_on
33.33Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
33.33Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.43Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
32.43Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
32.35Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
32.26Single4XT3Fractalkine4XT3-US28-Fractalkine
32.26Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.26Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
32.26Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
32.14Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
32.14Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
32.14Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
32.14Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
32.14Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
32.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
32.14Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
32.14Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
32.14Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
32.14Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
32.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
32.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
32.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
32.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
32.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
32.00Single7DFPSpiperone7DFP-D2-Spiperone
32.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
32.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
32.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
32.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
32.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8JWY2-1188JWY-A2A-2-118
32.00Single8JWZAB9288JWZ-A2A-AB928-Na
32.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
32.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
32.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
32.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
32.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
32.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
32.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
32.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
32.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
32.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
32.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
32.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
32.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
32.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
31.82Single5IU7Q274563465IU7-A2A-Q27456346-Na
31.82Single5IUBQ274563445IUB-A2A-Q27456344-Na
31.82Single5JTBZM-2413855JTB-A2A-ZM-241385
31.82Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
31.82Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
31.82Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
31.82Single5UVIZM-2413855UVI-A2A-ZM-241385
31.82Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.82Single6TPNHTL66416TPN-OX2-HTL6641
31.82Single6V9SGTPL114036V9S-OX1-GTPL11403
31.82Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
31.82Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
31.82Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
31.82Single6ZG9GSK10347026ZG9-M1-GSK1034702
31.82Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.82Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.82Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
31.82Single8IHKAcifran8IHK-HCA3-Acifran
31.82Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
31.82Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
31.82Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
31.82Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
31.82Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
31.82Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
31.82Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
31.82Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
31.82Consensusa2_offOrthosteric Liganda2a_off
31.82Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
31.82Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
31.82Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.82Consensushca_onOrthosteric Ligandhca2_on
31.43Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
31.25Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
31.25Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
31.03Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
31.03Single6W25SHU91196W25-MC4-SHU9119-Ca
31.03Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
31.03Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
31.03Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
31.03Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
31.03Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
31.03Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
31.03Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
31.03Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.77Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
30.77Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
30.77Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
30.77Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
30.77Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.77Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
30.77Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
30.77Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
30.77Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
30.77Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.77Consensuschemerin_onOrthosteric Ligandcml1_on
30.77Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
30.77Consensusendothelin_offOrthosteric Ligandetb_off
30.77Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
30.77Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
30.43Single3EMLZM-2413853EML-A2A-ZM-241385
30.43Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
30.43Single5IU8Q274563475IU8-A2A-Q27456347-Na
30.43Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
30.43Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
30.43Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
30.43Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
30.43Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
30.43Single5UIGCmpd-15UIG-A2A-Cmpd-1
30.43Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
30.43Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
30.43Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
30.43Single6PS1Timolol6PS1-β2-Timolol
30.43Single6S0LZM-2413856S0L-A2A-ZM-241385
30.43Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
30.43Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
30.43Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
30.43Single7PYRPSB-21157PYR-A2A-PSB-2115
30.43Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
30.43Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
30.43Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
30.43Single7UL4Alvimopan7UL4-μ-Alvimopan
30.43Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
30.43Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
30.43Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.43Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
30.43Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
30.43Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
30.43Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
30.43Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
30.43Single8K5DGSK2560738K5D-HCA2-GSK256073
30.43Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
30.43Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
30.43Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
30.43Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
30.43Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
30.43Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
30.43Single9CHXS-Carazolol9CHX-β2-S-Carazolol
30.43Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
30.43Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
30.43Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
30.43Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
30.43Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
30.43Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
30.43Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
30.43Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
30.43Consensushca_on_gpOrthosteric Ligandhca2_on_gp
30.43Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
30.30Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
30.30Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
30.30Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
30.30Consensusbradykinin_onOrthosteric Ligandbk2_on
30.30Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
30.30Consensusendothelin_onOrthosteric Ligandetb_on eta_on
30.30Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
30.00Single3OE6IT1t3OE6-CXCR4-IT1t
30.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
30.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
30.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
30.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
30.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
30.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
30.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
30.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
30.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
30.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
29.63Single6PT3DPI-2876PT3-δ-DPI-287
29.63Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
29.63Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
29.63Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
29.63Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
29.63Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
29.63Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
29.41Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
29.17Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
29.17Single5C1MBU725C1M-μ-BU72
29.17Single5IUAQ274563485IUA-A2A-Q27456348-Na
29.17Single5N2RPSB-365N2R-A2A-PSB-36-Na
29.17Single5WIUNemonapride5WIU-D4-Nemonapride
29.17Single5WIVNemonapride5WIV-D4-Nemonapride-Na
29.17Single5WQCEMPA5WQC-OX2-EMPA
29.17Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
29.17Single6D26Fevipiprant6D26-DP2-Fevipiprant
29.17Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
29.17Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
29.17Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
29.17Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
29.17Single6S0QZM-2413856S0Q-A2A-ZM-241385
29.17Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
29.17Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
29.17Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
29.17Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
29.17Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
29.17Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
29.17Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.17Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
29.17Single7W41PD1762527W41-BB2-PD176252
29.17Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
29.17Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
29.17Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
29.17Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
29.17Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
29.17Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
29.17Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.17Single8S4DCMF-0198S4D-Apelin-CMF-019
29.17Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
29.17Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
29.17Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
29.17Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
29.17Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
29.17Consensusbombesin_offOrthosteric Ligandbb2_off
29.17Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
29.17Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
29.17Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
29.17Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.17Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
29.17Consensusdp_offOrthosteric Liganddp2_off
29.17Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.17Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.17Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
29.17Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
29.17Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
29.17Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
29.17Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.17Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.03Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
29.03Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
29.03Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
29.03Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
29.03Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
29.03Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
29.03Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.03Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
29.03Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.03Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.57Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
28.57Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
28.57Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
28.57Single6HLLCP999946HLL-NK1-CP99994
28.57Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.57Single7QA8Peptide7QA8-STE2-Peptide
28.57Single7QA8Peptide7QA8-STE2-Peptide
28.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
28.57Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
28.57Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
28.57Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
28.57Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
28.57Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
28.57Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
28.57Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
28.57Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
28.57Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
28.57Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
28.57Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.57Single8IEBA1LYA8IEB-GPR156-A1LYA
28.57Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
28.57Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
28.57Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.57Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
28.57Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
28.57Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
28.57Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
28.57Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
28.57Consensuslpl_onOrthosteric Ligands1p_on lpa_on
28.57Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
28.57Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
28.12Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
28.12Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
28.00Single2YDVNECA2YDV-A2A-NECA
28.00Single3P0GBI1671073P0G-β2-BI167107
28.00Single4DJHJDTic4DJH-κ-JDTic
28.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
28.00Single4UHRCGS216804UHR-A2A-CGS21680
28.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
28.00Single5G53NECA5G53-A2A-NECA-Gs
28.00Single5TZRMK86665TZR-FFA1-MK8666
28.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
28.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
28.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
28.00Single6OS1TRV0266OS1-AT1-TRV026
28.00Single6WGTLSD6WGT-5-HT2A-LSD
28.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
28.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
28.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
28.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
28.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
28.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
28.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
28.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
28.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
28.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
28.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
28.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
28.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
28.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
28.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
28.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
28.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
28.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
28.00Single8XVLZibotentan8XVL-ETA-Zibotentan
28.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
28.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusa2_onOrthosteric Liganda2b_on
28.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
28.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
28.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
28.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
28.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
28.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
28.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
28.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
28.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
28.00Consensuslpa_onOrthosteric Ligandlpa1_on
28.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
28.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
28.00Consensustachykinin_offOrthosteric Ligandnk1_off
27.91Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
27.59Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
27.59Single6HLOAprepitant6HLO-NK1-Aprepitant
27.59Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
27.59Single7XNACYN1548067XNA-SST2-CYN154806
27.59Single8IEBA1LYA8IEB-GPR156-A1LYA
27.59Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
27.59Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
27.59Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.59Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
27.59Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
27.27Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
27.27Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
27.27Single6B73MP11046B73-κ-MP1104
27.27Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
27.27Single6ME2Ramelteon6ME2-MT1-Ramelteon
27.27Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.27Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
27.27Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
27.27Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
27.27Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
27.27Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
27.27Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
27.27Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
27.27Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
27.27Single7XRRLemborexant7XRR-OX2-Lemborexant
27.27Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
27.27Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
27.27Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
27.27Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.27Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
27.27Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
27.27Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
27.27Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
27.27Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
27.27Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
27.27Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
27.27Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.27Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.27Consensusalpha2_offOrthosteric Ligandalpha2c_off
27.27Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.27Consensusorexin_offOrthosteric Ligandox2_off ox1_off
27.27Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
26.92Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
26.92Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
26.92Single4AMIBucindolol4AMI-β1-Bucindolol
26.92Single4LDEBI1671074LDE-β2-BI167107
26.92Single4PY02MeSATP4PY0-P2Y12-2MeSATP
26.92Single4XEENeurotensin4XEE-NTS1-Neurotensin
26.92Single4XESNeurotensin4XES-NTS1-Neurotensin
26.92Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
26.92Single6A93Risperidone6A93-5-HT2A-Risperidone
26.92Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
26.92Single6OS2TRV0266OS2-AT1-TRV026
26.92Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
26.92Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.92Single6ZG4HTL00099366ZG4-M1-HTL0009936
26.92Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
26.92Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
26.92Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.92Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.92Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
26.92Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
26.92Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
26.92Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
26.92Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
26.92Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
26.92Single8JJ8Formoterol8JJ8-β2-Formoterol
26.92Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
26.92Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
26.92Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
26.92Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.92Consensusalpha1_offOrthosteric Ligandalpha1a_off
26.92Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
26.92Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
26.92Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
26.92Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.92Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.92Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
26.92Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
26.92Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
26.92Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
26.92Consensuslpl_offOrthosteric Ligands1p_off lpa_off
26.92Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
26.92Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.92Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
26.92Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.92Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.67Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.67Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
26.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.67Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.67Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.47Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
26.09Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
26.09Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
26.09Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
26.09Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
26.09Single4ZJCSB-6740424ZJC-OX1-SB-674042
26.09Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
26.09Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
26.09Single6AQFZM-2413856AQF-A2A-ZM-241385
26.09Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.09Single6MH8ZM-2413856MH8-A2A-ZM-241385
26.09Single6PS0S-Carazolol6PS0-β2-S-Carazolol
26.09Single6PS4ICI118-5516PS4-β2-ICI118-551
26.09Single6PS5S-Propranolol6PS5-β2-S-Propranolol
26.09Single6TPGEMPA6TPG-OX2-EMPA
26.09Single6TPKRetosiban6TPK-OT-Retosiban
26.09Single6VI4JDTic6VI4-κ-JDTic
26.09Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
26.09Single7AROLUF58337ARO-A2A-LUF5833-Na
26.09Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
26.09Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
26.09Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
26.09Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
26.09Single7T32ZM-2413857T32-A2A-ZM-241385
26.09Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.09Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.09Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
26.09Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
26.09Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
26.09Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
26.09Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
26.09Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
26.09Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
26.09Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.09Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
26.09Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
26.09Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
26.09Single8K5CAcipimox8K5C-HCA2-Acipimox
26.09Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
26.09Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.09Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
26.09Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
26.09Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
26.09Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
26.09Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.09Consensusgrh_offOrthosteric Ligandgnrh1_off
26.09Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.09Consensusvasop-oxy_offOrthosteric Ligandot_off
25.93Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
25.93Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.93Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
25.93Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
25.93Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
25.93Single5X93K-87945X93-ETB-K-8794
25.93Single6H7LDobutamine6H7L-β1-Dobutamine
25.93Single6IBLArformoterol6IBL-β1-Arformoterol
25.93Single6K1QIRL25006K1Q-ETB-IRL2500
25.93Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
25.93Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
25.93Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
25.93Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
25.93Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
25.93Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
25.93Single7UM4AS26747237UM4-5-HT5A-AS2674723
25.93Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
25.93Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
25.93Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
25.93Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.93Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.93Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.93Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
25.93Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.93Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
25.93Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
25.93Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
25.93Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.93Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.93Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.93Consensusprostanoid_offOrthosteric Ligandep_off dp_off
25.81Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.81Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single2Y04Salbutamol2Y04-β1-Salbutamol
25.00Single3NY8ICI118-5513NY8-β2-ICI118-551
25.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
25.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single5ZTYAM102575ZTY-CB2-AM10257
25.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
25.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
25.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
25.00Single6TOTLemborexant6TOT-OX1-Lemborexant
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
25.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
25.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
25.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
25.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
25.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
25.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
25.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
25.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
25.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
25.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
25.00Single7V3ZCP559407V3Z-CB1-CP55940
25.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
25.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
25.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
25.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
25.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
25.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
25.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
25.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
25.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
25.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
25.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
25.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
25.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
25.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
25.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
25.00Single8JJOAlprenolol8JJO-β2-Alprenolol
25.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
25.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
25.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
25.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
25.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
25.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.00Single8X5YAstemizole8X5Y-H1-Astemizole
25.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
25.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
25.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
25.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
25.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
25.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
25.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
25.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
25.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
25.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
25.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
25.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
25.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
25.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
25.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
25.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
25.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
25.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
25.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
25.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
25.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
25.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
25.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
24.24Single6FJ3PTH6FJ3-PTH1-PTH
24.24Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
24.24Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
24.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.14Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
24.14Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
24.14Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
24.14Single8IEPA1LYA8IEP-GPR156-A1LYA
24.14Single8IEPA1LYA8IEP-GPR156-A1LYA
24.14Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
24.14Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
24.14Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.14Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.14Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
24.14Consensussomatostatin_offOrthosteric Ligandsst2_off
24.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
24.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
24.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
24.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
24.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
24.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
24.00Single5TVNLSD5TVN-5-HT2B-LSD
24.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
24.00Single6HLPNetupitant6HLP-NK1-Netupitant
24.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
24.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
24.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
24.00Single6PS6Timolol6PS6-β2-Timolol
24.00Single6TP6Filorexant6TP6-OX1-Filorexant
24.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
24.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
24.00Single7C4SS1P7C4S-S1P3-S1P
24.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
24.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
24.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
24.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
24.00Single7WC6LSD7WC6-5-HT2A-LSD
24.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
24.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
24.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
24.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
24.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
24.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
24.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
24.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
24.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
24.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
24.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
24.00Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
24.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
24.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
24.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
24.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
24.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
24.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
24.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
24.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
24.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
24.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
24.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
24.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
24.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
24.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Consensustrace-amine_onOrthosteric Ligandta1_on
23.81Single6ME5Agomelatine6ME5-MT1-Agomelatine
23.81Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
23.81Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.81Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.81Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
23.81Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.81Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
23.81Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.81Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
23.68Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.68Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
23.53Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
23.53Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
23.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
23.33Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
23.33Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
23.08Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
23.08Single4BV0Neurotensin4BV0-NTS1-Neurotensin
23.08Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
23.08Single5D5AS-Carazolol5D5A-β2-S-Carazolol
23.08Single5D5BS-Carazolol5D5B-β2-S-Carazolol
23.08Single5V54Methiothepin5V54-5-HT1B-Methiothepin
23.08Single5XR8AM8415XR8-CB1-AM841
23.08Single5XRAAM115425XRA-CB1-AM11542
23.08Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.08Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
23.08Single7FEECP559407FEE-CB1-CP55940-ZCZ011
23.08Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
23.08Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
23.08Single7R0CAVP7R0C-V2-AVP-Arrestin2
23.08Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
23.08Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
23.08Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
23.08Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
23.08Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
23.08Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
23.08Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
23.08Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
23.08Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
23.08Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
23.08Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
23.08Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
23.08Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
23.08Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
23.08Consensus5ht1_offOrthosteric Ligand5ht1b_off
23.08Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
23.08Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
23.08Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
23.08Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
23.08Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.08Consensusneurotensin_onOrthosteric Ligandnts1_on
23.08Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.08Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
23.08Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
23.08Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
22.86Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.86Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.86Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
22.86Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
22.86Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.73Single3PBLEticlopride3PBL-D3-Eticlopride
22.73Single6TP4ACT-4622066TP4-OX1-ACT-462206
22.73Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.73Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
22.73Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
22.73Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
22.73Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
22.73Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
22.73Single8K5BNiacin8K5B-HCA2-Niacin
22.73Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
22.73Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
22.73Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
22.73Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
22.73Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
22.73Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
22.73Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
22.73Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
22.73Consensusgq_nucleotideOrthosteric Ligandgq_p2y
22.73Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.58Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
22.58Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
22.58Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.58Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Single3D4STimolol3D4S-β2-Timolol
22.22Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
22.22Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
22.22Single6CM4Risperidone6CM4-D2-Risperidone
22.22Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
22.22Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
22.22Single6KQICP559406KQI-CB1-CP55940-Org27569
22.22Single6YVRNTS8-136YVR-NTS1-NTS8-13
22.22Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
22.22Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
22.22Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
22.22Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
22.22Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
22.22Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
22.22Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
22.22Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
22.22Single8XWACXCL18XWA-CXCR2-CXCL1
22.22Single8XWMCXCL68XWM-CXCR2-CXCL6
22.22Single8XWSCXCL58XWS-CXCR2-CXCL5
22.22Single8XYIVUF106618XYI-CXCR3-VUF10661
22.22Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
22.22Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
22.22Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
22.22Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
22.22Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
22.22Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
22.22Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
22.22Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.22Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
22.22Consensuslpa_offOrthosteric Ligandlpa1_off
22.22Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
22.22Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
21.88Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
21.88Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
21.88Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
21.88Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.88Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
21.88Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
21.74Single3PWHZM-2413853PWH-A2A-ZM-241385
21.74Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
21.74Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.74Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.74Single5WS3EMPA5WS3-OX2-EMPA
21.74Single5ZKQABT-4915ZKQ-PAF-ABT-491
21.74Single6AKXA4R6AKX-CCR5-A4R
21.74Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
21.74Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.74Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
21.74Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
21.74Single6TODEMPA6TOD-OX1-EMPA-Na
21.74Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.74Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.74Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.74Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
21.74Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.74Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
21.74Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.74Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.74Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
21.74Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
21.74Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
21.74Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
21.74Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
21.74Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
21.74Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
21.74Single8IWESpermidine8IWE-TA9-Spermidine
21.74Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
21.74Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
21.74Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
21.74Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
21.74Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
21.74Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.74Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
21.74Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
21.74Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
21.74Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
21.74Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
21.74Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
21.74Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
21.74Consensusangiotensin_offOrthosteric Ligandat1_off
21.74Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.74Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
21.74Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.74Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
21.74Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
21.74Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.74Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
21.43Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
21.43Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
21.43Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
21.43Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.43Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
21.43Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
21.43Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
21.43Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
21.43Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.43Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
21.43Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
21.43Single8XVUCXCL28XVU-CXCR2-CXCL2
21.43Single8XWFCXCL38XWF-CXCR2-CXCL3
21.43Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
21.43Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
21.21Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
21.21Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
21.21Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
21.21Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
21.05Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
20.83Single2YDOAdenosine2YDO-A2A-Adenosine
20.83Single3REYXAC3REY-A2A-XAC
20.83Single3RZECidoxepin3RZE-H1-Cidoxepin
20.83Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.83Single4MBSMaraviroc4MBS-CCR5-Maraviroc
20.83Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.83Single6A94Zotepine6A94-5-HT2A-Zotepine
20.83Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
20.83Single6KUXRS-799486KUX-α2a-RS-79948
20.83Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
20.83Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.83Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.83Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.83Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.83Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
20.83Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
20.83Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
20.83Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
20.83Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
20.83Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single7UL3Famotidine7UL3-H2-Famotidine
20.83Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
20.83Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.83Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
20.83Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
20.83Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.83Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
20.83Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.83Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
20.83Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
20.83Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
20.83Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.83Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
20.83Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
20.83Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.83Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.83Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
20.83Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
20.83Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
20.83Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
20.83Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9BJKNaloxone9BJK-μ-Naloxone-NAM
20.83Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
20.83Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
20.83Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
20.83Consensusalpha1_onOrthosteric Ligandalpha1a_on
20.83Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
20.83Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.83Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
20.83Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.83Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.83Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.83Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.83Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.69Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.69Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.69Single8IEIA1LYA8IEI-GPR156-A1LYA
20.69Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.69Single8XQJJN2418XQJ-Apelin-JN241
20.69Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
20.69Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
20.69Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.69Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.69Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.59Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.59Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.59Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
20.59Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
20.51Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
20.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.00Single4QIMANTA XV4QIM-SMO-ANTA XV
20.00Single4QKX35V4QKX-β2-35V
20.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
20.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6H7MSalbutamol6H7M-β1-Salbutamol
20.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
20.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
20.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
20.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
20.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
20.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
20.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
20.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Single8IEIA1LYA8IEI-GPR156-A1LYA
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8JXRLSD8JXR-D1-LSD
20.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
20.00Single8RLNLUF58348RLN-A2A-LUF5834
20.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
20.00Single8T1WCVN4248T1W-GPR6-CVN424
20.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
20.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Single8X64Desloratadine8X64-H1-Desloratadine
20.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
20.00Single8XWNCXCL88XWN-CXCR2-CXCL8
20.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
20.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
20.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
20.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
20.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.00Consensushistamine_offOrthosteric Ligandh1_off
20.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.44Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
19.44Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
19.44Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
19.44Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
19.44Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
19.35Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.35Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.35Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
19.23Single2Y00Dobutamine2Y00-β1-Dobutamine
19.23Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.23Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
19.23Single5XPRBosentan5XPR-ETB-Bosentan
19.23Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
19.23Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
19.23Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.23Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
19.23Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
19.23Single6Z4SSR486926Z4S-NTS1-SR48692
19.23Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
19.23Single7SINNPS-21437SIN-CaS-NPS-2143
19.23Single7SINNPS-21437SIN-CaS-NPS-2143
19.23Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
19.23Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
19.23Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
19.23Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
19.23Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
19.23Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
19.23Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
19.23Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
19.23Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
19.23Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
19.23Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
19.23Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
19.23Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
19.23Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
19.05Single3RFMCaffeine3RFM-A2A-Caffeine
19.05Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
19.05Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
19.05Single8A2OTheophylline8A2O-A2A-Theophylline-Na
19.05Single9CHUNoradrenaline9CHU-β2-Noradrenaline
19.05Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
19.05Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.92Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.75Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
18.52Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
18.52Single5V56TC1145V56-SMO-TC114
18.52Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
18.52Single7F1TMIP-1a7F1T-CCR5-MIP-1a
18.52Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
18.52Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
18.52Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.52Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
18.52Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
18.52Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
18.52Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
18.52Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
18.52Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.52Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
18.52Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
18.52Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
18.52Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.52Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
18.42Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
18.18Single3UZAGTPL92363UZA-A2A-GTPL9236
18.18Single4XNWMRS25004XNW-P2Y1-MRS2500
18.18Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
18.18Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
18.18Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
18.18Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
18.18Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
18.18Single7WC5Psilocin7WC5-5-HT2A-Psilocin
18.18Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
18.18Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
18.18Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.18Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.18Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
18.18Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
18.18Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
18.18Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.18Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
18.18Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
18.18Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
18.18Consensus5ht2_onOrthosteric Ligand5ht2b_on
18.18Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.18Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.18Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
18.18Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
17.95Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
17.95Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
17.86Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
17.86Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
17.86Single7K15MKD0467K15-BLT1-MKD046-Na
17.86Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
17.86Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
17.86Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
17.86Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
17.86Single8XQJJN2418XQJ-Apelin-JN241
17.86Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
17.86Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
17.86Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
17.86Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
17.65Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.65Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.39Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.39Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
17.39Single7SRQLSD7SRQ-5-HT2B-LSD
17.39Single7UL2SR486927UL2-NTS1-SR48692-Na
17.39Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
17.39Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
17.39Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
17.39Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
17.39Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
17.39Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.39Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.39Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.39Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
17.39Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
17.39Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
17.39Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.39Consensusneurotensin_offOrthosteric Ligandnts1_off
17.39Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
17.24Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
17.24Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
17.24Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.24Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
17.14Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
17.14Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
17.14Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.07Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
16.67Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
16.67Single5EE7MK08935EE7-Glucagon-MK0893
16.67Single6AKYMaraviroc6AKY-CCR5-Maraviroc
16.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
16.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.67Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.67Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
16.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
16.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SK9CCX6627SK9-ACKR3-CCX662
16.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
16.67Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
16.67Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
16.67Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
16.67Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
16.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
16.67Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
16.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
16.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
16.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.67Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
16.67Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
16.67Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
16.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
16.67Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.22Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
16.22Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.22Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
16.22Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.13Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
16.13Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
16.13Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
16.13Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
16.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.00Single6ZINSR486926ZIN-NTS1-SR48692
16.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
16.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
16.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
16.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
16.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
16.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.00Single7VV6C48/807VV6-MRGPRX2-C48/80
16.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
16.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
16.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
16.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
16.00Consensussensory_offOrthosteric Ligandopsins_off
15.79Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.62Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
15.62Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
15.62Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
15.38Single2Y01Dobutamine2Y01-β1-Dobutamine
15.38Single4DAJTiotropium4DAJ-M3-Tiotropium
15.38Single4MQSIperoxo4MQS-M2-Iperoxo
15.38Single4U14Tiotropium4U14-M3-Tiotropium
15.38Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
15.38Single5T04Neurotensin5T04-NTS1-Neurotensin
15.38Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
15.38Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
15.38Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
15.38Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.38Single6GPSMK08126GPS-CCR2-MK0812
15.38Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
15.38Single7BU7BI1671077BU7-β1-BI167107
15.38Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.38Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.38Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.38Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.38Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.38Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.38Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.38Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
15.38Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.38Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
15.38Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
15.38Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
15.38Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
15.38Consensusblt_onOrthosteric Ligandblt1_on
15.38Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
15.38Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
15.38Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
15.38Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
15.38Consensusleukotriene_onOrthosteric Ligandblt_on
15.38Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
15.15Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
15.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
15.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
14.81Single4JKVTaladegib4JKV-SMO-Taladegib
14.81Single6GPXMK08126GPX-CCR2-MK0812
14.81Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.81Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.81Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
14.81Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
14.81Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
14.81Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
14.81Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
14.81Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
14.81Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
14.81Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
14.81Consensusblt_offOrthosteric Ligandblt1_off
14.81Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.81Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
14.81Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
14.29Single4U15Tiotropium4U15-M3-Tiotropium
14.29Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
14.29Single5V57TC1145V57-SMO-TC114
14.29Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
14.29Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
14.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.29Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.29Single6OL9Tiotropium6OL9-M5-Tiotropium
14.29Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
14.29Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.29Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single8EA0Iperoxo8EA0-M3-Iperoxo
14.29Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
14.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
14.29Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.29Single8PWNTheophylline8PWN-A2A-Theophylline
14.29Single9BJKNAM9BJK-μ-Naloxone-NAM
14.29Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.29Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
14.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.29Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
13.89Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.79Single4N4WSANT-14N4W-SMO-SANT-1
13.79Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.79Single5CXVTiotropium5CXV-M1-Tiotropium
13.79Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.79Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.79Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
13.79Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
13.79Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
13.79Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.79Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.79Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.79Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
13.64Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
13.64Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
13.64Consensusp2y_offOrthosteric Ligandp2y1_off
13.51Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
13.51Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
13.51Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.33Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.33Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
13.33Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.33Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8XVJMacitentan8XVJ-ETA-Macitentan
13.33Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
13.16Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
13.04Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
13.04Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
13.04Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.04Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
13.04Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
13.04Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.04Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
13.04Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
13.04Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.04Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.04Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Consensusgi_sensoryOrthosteric Ligandgi_opsins
13.04Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.04Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.04Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.04Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
12.90Single6KNMJN241-96KNM-Apelin-JN241-9
12.90Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
12.90Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
12.90Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.82Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
12.50Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
12.50Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
12.50Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
12.50Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
12.50Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
12.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
12.50Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.50Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
12.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
12.50Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
12.50Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
12.50Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
12.50Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
12.50Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.50Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.20Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
12.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
12.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
12.00Single4QINSAG1.54QIN-SMO-SAG1.5
12.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
12.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
12.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
12.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
12.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
12.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
12.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
11.90Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
11.90Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.90Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
11.54Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.54Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.54Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
11.54Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
11.54Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
11.54Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
11.54Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
11.54Single8K2WAMG4878K2W-CXCR3-AMG487
11.54Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
11.54Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
11.54Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.54Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
11.43Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.43Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
11.43Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
11.11Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
11.11Single5DSGTiotropium5DSG-M4-Tiotropium
11.11Single5TGZAM65385TGZ-CB1-AM6538
11.11Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.11Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
11.11Single7YXAONO-54306087YXA-S1P5-ONO-5430608
11.11Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
11.11Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
11.11Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
11.11Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
11.11Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
11.11Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
11.11Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
10.71Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.71Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.71Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.71Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.71Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
10.71Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.71Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
10.71Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.71Consensusep_offOrthosteric Ligandep4_off
10.71Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.71Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.53Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.34Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.34Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.34Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
10.34Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
10.34Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
10.34Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
10.34Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
10.34Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.34Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
10.26Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.26Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
10.00Single5X33BIIL2605X33-BLT1-BIIL260
10.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
10.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
9.68Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
9.68Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
9.68Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
9.68Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
9.68Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single5MZPCaffeine5MZP-A2A-Caffeine-Na
9.52Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
9.38Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
9.30Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
9.09Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
9.09Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.82Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
8.70Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
8.70Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.70Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
8.70Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.70Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.70Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
8.70Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
8.70Consensussensory_onOrthosteric Ligandopsins_on
8.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
8.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
8.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.33Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
8.33Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
8.33Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
8.33Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
8.33Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
8.33Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
8.33Single8JPSCCL78JPS-ACKR1-CCL7
8.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
8.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
8.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
8.11Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.11Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
8.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
8.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
8.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
8.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
8.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
8.00Single9B9Y7DY9B9Y-CB1-7DY
7.69Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
7.69Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
7.69Single5U09Taranabant5U09-CB1-Taranabant
7.69Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
7.69Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
7.69Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
7.69Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
7.69Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
7.69Single9BA0A1AKN9BA0-CB1-A1AKN
7.41Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
7.41Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
7.41Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
7.41Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
7.41Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
7.14Single6IIVDaltroban6IIV-TP-Daltroban
7.14Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
7.14Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
7.14Single9B9ZA1AKO9B9Z-CB1-A1AKO
6.90Single5CGCHTL142425CGC-mGlu5-HTL14242
6.90Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.67Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.67Single7P2L4YI7P2L-mGlu5-4YI
6.67Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.45Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
6.45Single6IIURamatroban6IIU-TP-Ramatroban
6.45Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5CGDHTL142425CGD-mGlu5-HTL14242
6.25Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.06Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
5.88Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.71Single7SHEPI; PE7SHE-GPR158-PI; PE
4.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.35Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
4.35Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
4.35Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
4.17Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.17Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
4.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
3.85Single6LI0C176LI0-GPR52-C17
3.85Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.85Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.85Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.70Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.70Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
3.70Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
3.70Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
3.57Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.57Single8IYXYL-3658IYX-GPR34-YL-365
3.57Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.57Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
3.45Single6FFHFenobam6FFH-mGlu5-Fenobam
3.45Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.23Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
3.23Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.23Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.12Single7SHEPI; PE7SHE-GPR158-PI; PE
3.03Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.78Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7MBX 7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
Net Summary
Imin 2.51
Number of Linked Nodes 854
Number of Links 1192
Number of Hubs 240
Number of Links mediated by Hubs 850
Number of Communities 16
Number of Nodes involved in Communities 356
Number of Links involved in Communities 582
Path Summary
Number Of Nodes in MetaPath 71
Number Of Links MetaPath 70
Number of Shortest Paths 3447962
Length Of Smallest Path 3
Average Path Length 27.5105
Length of Longest Path 54
Minimum Path Strength 1.21
Average Path Strength 5.87379
Maximum Path Strength 24.355
Minimum Path Correlation 0.7
Average Path Correlation 0.989932
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 41.1399
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 62.6401
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_peptidegs_cck
gs_melanocortin
gs_vasop-oxy



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_cck.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.