Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.01 5.87333426
2G.S1.02 5.268535
3G.S1.05 4.138529
4G.S1.06 4.07333459
5G.s1h1.05 2.115459
6G.H1.01 4.65733559
7G.S2.01 3.56533528
8G.S2.08 7.69167435
9G.S3.01 4.6925434
10G.S3.02 4.43833424
11G.S3.03 8.28333437
12G.S3.04 7.5825427
13G.S3.06 4.65191726
14G.S3.08 3.59733529
15G.s3h2.03 4.19619729
16G.H2.02 3.35167428
17G.H2.03 4.7125429
18G.H2.06 4.93952729
19G.H2.07 5.68729
20G.H2.08 3.38583428
21G.H2.09 5.63333428
22G.h2s4.01 5.228529
23G.S4.04 5.45417489
24G.S4.05 2.89667457
25G.s4h3.02 3.40667409
26G.s4h3.03 3.709174198
27G.s4h3.04 5.725335158
28G.s4h3.05 6.085834159
29G.H3.01 3.531335199
30G.H3.09 4.822589
31G.H3.13 2.92167486
32G.H3.14 6.72167408
33G.H3.15 4.14083428
34G.H3.17 6.27714725
35G.H3.18 6.0575429
36G.S5.03 2.84833458
37G.S5.04 3.91267589
38G.S5.05 2.92905759
39G.S5.07 4.62917459
40G.HG.04 5.86933508
41G.HG.07 4.551335159
42G.HG.13 3.860675156
43G.hgh4.01 4.02583405
44G.hgh4.02 6.426178
45G.hgh4.05 8.21833406
46G.H4.03 5.0125404
47G.H4.10 5.826675176
48G.H4.15 3.96167488
49G.h4s6.01 2.89667405
50G.h4s6.02 4.38667487
51G.h4s6.11 3.98333487
52G.S6.02 4.42952738
53G.H5.08 4.59389638
54G.H5.13 4.03714737
55G.H5.14 3.28333436
56G.H5.26 5.81833407
57b.h2x1 3.0125405
58b.h2x5 3.856674225
59b.lhb1x9 2.88083403
60b.lhb1x11 2.929335114
61b.b1x6 7.90083469
62b.l1x3 6.77944669
63b.b2x1 7.85267528
64b.b2x3 3.42867506
65b.b2x5 6.462507
66b.b3x3 3.226674138
67b.b3x4 3.93469
68b.l3x2 3.85667469
69b.b4x3 3.285335137
70b.b4x4 7.42917468
71b.b4x6 7.68333769
72b.b5x3 5.78611669
73b.b5x5 4.62417405
74b.b5x7 5.65083407
75b.l5x1 3.245834138
76b.l5x5 6.18714729
77b.b6x3 2.719174138
78b.b6x5 3.42389606
79b.b7x1 5.79867544
80b.b7x2 2.64667408
81b.b7x4 2.768334138
82b.l7x2 3.96067529
83b.b8x3 2.94278646
84b.b8x4 4.700566136
85b.l8x3 2.72083443
86b.l8x7 4.06917443
87b.l8x9 3.72543
88b.b9x4 6.12833409
89b.l9x3 4.4045169
90b.l9x6 3.94519928
91b.b10x5 3.78952749
92b.l10x1 4.088543
93b.l10x4 3.18833403
94b.b11x1 4.3925445
95b.l11x2 4.32133509
96b.b12x6 7.928896168
97b.b12x7 4.15083409
98b.l12x3 4.02167405
99b.b13x7 6.77933597
100b.l13x3 6.89167699
101b.l13x6 4.1575429
102b.l13x7 3.64267599
103b.b15x1 5.22722699
104b.b15x2 4.39083476
105b.b15x3 4.40417499
106b.l15x1 4.07133527
107b.l15x2 4.876599
108b.b16x4 8.66167496
109b.b16x5 4.62583405
110b.b16x6 7.2119798
111b.b16x7 4.654174249
112b.b17x7 8.1375478
113b.l17x3 7.45444679
114b.l17x6 5.24533529
115b.b18x3 3.6775478
116b.b18x5 4.06167405
117b.l18x1 5.397627146
118b.l18x2 4.741674147
119b.b19x2 5.75556676
120b.b19x4 5.8025478
121b.l19x1 5.55667429
122b.l19x2 6.29167409
123b.b20x4 7.21167678
124b.b20x6 6.48889676
125b.b21x1 7.644577
126b.b21x2 2.49406
127b.b21x5 4.48417404
128b.b21x7 6.41333505
129b.l21x5 3.5254104
130b.b22x5 4.598896147
131b.l22x5 6.10583409
132b.b23x1 3.8875405
133b.b23x2 4.14667406
134b.b23x6 6.633336107
135b.l23x1 7.59333406
136b.l23x2 4.6154108
137b.b24x2 4.004174105
138b.b24x4 6.8365106
139b.b24x5 3.44405
140b.b24x6 6.168334108
141b.l24x2 4.4325406
142b.l24x3 4.474174225
143b.b25x3 5.762675105
144b.b25x7 6.1854117
145b.l25x3 8.531674119
146b.l25x6 10.8183428
147b.b26x3 3.6925256
148b.l26x1 5.363334237
149b.b27x1 2.789174256
150b.l27x1 8.66429729
151b.l27x2 5.416674119
152b.b28x3 3.656567
153b.b28x4 4.7945116
154b.b28x6 7.112675119
155g.h1x9 2.735406
156g.h2x11 7.456674146
157g.ctx3 5.56509
158g.ctx6 3.42506
159g.ctx14 4.824129
160g.ctx15 5.561674129
161g.ctx16 4.433336128
162NT 2.59444613
1631x39 5.08933507
1641x50 5.2175409
1651x53 2.78167409
1662x40 5.08167408
1672x42 3.9025407
1682x46 5.202519
1692x50 5.362519
1702x53 2.9975417
1712x57 5.54278617
172E1x50 7.26889618
173E1x52 5.65222607
1743x32 5.06583416
1753x34 2.2975405
1763x37 3.27167406
1773x43 3.85083418
1783x49 5.415408
1793x50 4.10867519
1803x51 6.8625437
1813x53 4.1625438
182I2 5.456391236
1834x46 3.98754277
1844x50 4.896675279
1854x61 3.7075415
1864x65 4.02667415
187E2 17.7251613
188E2x52 5.2975414
1895x36 5.83333414
1905x39 4.87333416
1915x461 4.9225416
1925x47 5.2275408
1935x58 4.65556619
1945x64 2.86867535
1955x68 3.67833436
1966x26 3.50333734
1976x30 3.28556637
1986x44 3.148519
1996x48 3.92889618
2006x54 3.77889615
2016x59 5.84417414
202E3 4.87381713
2037x38 8.15416
2047x42 5.455417
2057x49 4.7275419
2067x52 2.86067518
2077x53 3.71583819
2088x50 4.052867218
209Lig 17.8922710
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b4x6 b.b5x3 11.42119.28YesYes699
2b.b26x2 b.b2x3 26.80184.86NoYes076
3b.b26x1 b.b26x2 26.95184.01333NoNo097
4b.b26x1 b.l27x1 27.12394.53NoYes099
5b.b2x3 b.b3x4 10.82392.55667YesYes069
6G.H3.17 b.l27x1 21.72512.18667YesYes259
7G.H2.08 G.H3.17 43.99962.35YesYes285
8G.H2.04 G.H2.08 44.58163.76NoYes098
9G.H2.04 G.H3.08 99.99613.64NoNo099
10G.H3.08 G.S4.04 1005.28NoYes099
11G.H3.09 G.S4.04 88.116411.0733YesYes899
12G.H3.09 G.S5.02 86.11094.18667YesNo896
13G.S5.02 G.h4s6.11 85.43152.90667NoYes867
14G.h4s6.04 G.h4s6.11 85.78162.47667NoYes057
15G.h3s5.01 G.h4s6.04 90.31313.02NoNo035
16G.h3s5.01 G.h3s5.02 90.28114.33667NoNo034
17G.H5.21 G.h3s5.02 90.24881.84333NoNo044
18G.H5.17 G.H5.21 36.38722.39667NoNo054
19G.H5.13 G.H5.17 23.5965.07YesNo075
20G.H5.13 G.S6.02 20.60177.66333YesYes378
215x68 G.H5.13 20.23635.97YesYes367
225x64 5x68 17.51912.94333YesYes356
235x64 I2 15.85182.70667YesYes356
246x26 G.H5.17 12.68682.46YesNo045
255x68 6x26 12.75752.20333YesYes364
265x68 G.H5.16 15.38413.59667YesNo366
27G.H5.16 I2 15.20913.38667NoYes366
28G.S5.03 G.S5.05 13.1832.93YesYes589
29G.H5.10 G.S5.03 17.42343.79NoYes078
30G.H5.10 G.S6.02 17.77093.11333NoYes078
31G.H2.04 G.H2.07 58.93375.33333NoYes099
32G.H2.07 b.l9x6 47.13144.5YesYes298
33G.H2.06 b.l9x6 34.96013.18333YesYes298
34G.H2.06 b.l17x6 31.95217.83667YesYes299
35b.l19x1 b.l21x8 15.53922.23667YesNo094
36b.l21x8 b.l23x1 15.62752.79333NoYes046
37b.l23x1 b.l25x6 27.726919.06YesYes068
38G.H3.06 G.hgh4.02 10.7696.84667NoYes068
39G.H5.21 G.H5.26 61.21873.72NoYes047
403x53 G.H5.23 10.82553.85667YesNo084
413x50 G.H5.23 10.97353.71667YesNo094
423x50 G.H5.25 59.72626.47667YesNo097
43G.H5.20 G.H5.25 59.87033.69NoNo087
44G.H5.20 G.H5.26 60.09776.49667NoYes087
453x53 I2 16.95082.57333YesYes386
463x50 7x53 40.85313.43YesYes199
47b.l17x5 b.l19x1 10.52783.92333NoYes269
48b.l17x5 b.l19x2 39.80326.87NoYes069
49b.l17x4 b.l19x2 12.46089.52667NoYes039
50b.b20x4 b.l17x4 12.27044.65333YesNo083
51b.b20x4 b.b20x6 22.63473.56667YesYes786
52b.b17x7 b.b20x6 25.94217.14667YesYes786
53b.b17x7 b.b21x1 24.02928.76YesYes787
54b.1x19 b.b21x1 18.94073.97NoYes067
55b.1x15 b.1x19 18.38365.37333NoNo076
56b.1x12 b.1x15 17.82623.21333NoNo067
57b.1x12 b.1x9 15.59432.2NoNo064
58b.1x13 b.1x9 15.03563.94333NoNo014
59b.b20x2 b.l19x2 12.67323.37333NoYes069
60b.b20x2 b.b20x4 12.29255.60333NoYes068
61b.b19x6 b.l19x2 14.49245.39667NoYes099
62b.b19x6 b.l17x3 14.306710.6933NoYes099
63b.b20x6 b.l17x3 11.36443.01333YesYes769
64b.l21x7 b.l23x1 17.22894.66667NoYes056
65b.l21x7 b.l23x2 17.0016.74333NoYes058
66b.b23x6 b.l23x2 14.00393.06667YesYes1078
67b.b23x6 b.b24x6 12.44276.43YesYes1078
68b.b21x7 b.b24x6 12.11768.68YesYes058
69b.b10x1 b.l9x6 14.66593.81667NoYes098
70b.b10x1 b.b11x5 14.42782.71667NoNo096
71b.b11x5 b.l13x7 14.2443.23333NoYes069
72b.b22x1 b.l23x1 17.45193.85333NoYes086
73b.b22x1 b.b22x2 17.24884.26667NoNo088
74b.b22x2 b.b26x3 17.0583NoYes086
75b.1x10 b.1x13 13.91762.21667NoNo011
763x50 5x58 23.77143.09YesYes199
775x54 5x58 21.2634.03333NoYes189
785x54 6x44 21.13542.51333NoYes189
796x44 6x48 34.73163.34YesYes198
803x36 6x48 30.35493.62333NoYes178
813x36 Lig 28.71482.52NoYes170
823x43 7x53 21.98794.69YesYes189
833x43 6x44 22.36772.43667YesYes189
84b.l17x5 b.l17x6 29.45622.45333NoYes269
85G.H3.17 b.l25x6 22.12993YesYes258
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT2.143331YesYes3311
1x32NT3.326671NoYes3321
1x397x355.573330YesNo7422
1x397x385.080YesYes7621
2x532x562.816671YesNo7722
2x533x362.543331YesNo7721
2x563x326.616671NoYes7621
2x567x422.71NoYes7722
2x603x322.833331NoYes6611
2x607x3813.691NoYes6611
2x60Lig9.603331NoYes6010
2x63E1x5010.291NoYes6812
2x63Lig19.03331NoYes6010
2x647x342.163331NoNo4511
2x647x353.963331NoNo4412
2x67Lig8.30NoYes4010
E1x49E29.771NoYes5321
3x25E1x506.963331NoYes9822
E1x50E23.253331YesYes8321
E1x50E2x503.916671YesNo8922
3x22E28.926671NoYes3321
3x25E2x506.066671NoNo9922
3x283x322.753330NoYes5621
3x32Lig8.061YesYes6010
3x366x483.623331NoYes7812
3x375x4615.553330YesYes6621
4x605x396.026670NoYes8621
4x615x396.813331YesYes5611
4x64E213.30331NoYes5321
4x65E2x525.683331YesYes5421
E2E284.061YesYes3311
E2E2x504.533331YesNo3912
E2E2x514.626671YesNo3311
E2Lig42.46671YesYes3010
E2x51Lig7.286671NoYes3010
E2E2x526.976671YesYes3411
5x36E28.306671YesYes4311
5x39E23.236671YesYes6311
5x366x596.353331YesYes4411
5x36Lig5.183331YesYes4010
5x406x597.256671NoYes5411
5x40Lig6.933331NoYes5010
5x435x4618.156671NoYes5611
5x43Lig5.106671NoYes5010
5x461Lig4.143331YesYes6010
6x516x554.103330NoNo7521
6x547x302.816671YesNo5321
6x547x346.786671YesNo5521
6x55Lig14.261NoYes5010
6x586x592.616671NoYes4411
6x58Lig18.77331NoYes4010
6x59Lig7.151YesYes4010
6x61E39.833330NoYes4321
7x30E34.043331NoYes3311
7x30Lig7.681NoYes3010
7x31Lig11.01330NoYes4010
7x34Lig11.391NoYes5010
7x387x428.756671YesYes6712
LigNT3.186671YesYes0301
E3Lig10.411YesYes3010
E2x52Lig5.041YesYes4010
2x64Lig2.523331NoYes4010
4x61Lig2.941YesYes5010
5x39Lig3.416671YesYes6010
3x36Lig2.521NoYes7010
7x38Lig5.073331YesYes6010
7x29NT3.353331NoYes3321
2x537x422.913331YesYes7722
2x63E23.436671NoYes6311
3x28E1x502.456670NoYes5822
3x334x612.433330NoYes4521
6x546x582.426671YesNo5421
6x54E32.131YesYes5321
3x25E22.726671NoYes9321
4x614x652.643331YesYes5512
4x65E22.883331YesYes5321
5x36E2x523.491YesYes4411
E3E33.593331YesYes3311
7x27Lig2.211NoYes1010
5x465x4611.836670NoYes5621
1x31NT1.413331NoYes4321
5x33E21.033330NoYes1321
7x267x270.9033330NoNo0121
6x57E30.5133330NoYes4321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
100.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
80.77Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
80.77Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
76.92Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
76.67Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
71.43Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
71.43Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
71.43Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
69.23Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
65.38Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
64.29Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
63.33Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
62.96Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
62.96Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
62.96Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
60.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
60.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
60.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
60.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
58.62Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
57.14Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
57.14Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
57.14Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
57.14Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
56.67Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
55.56Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
55.17Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
54.84Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
53.85Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
53.57Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
53.57Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
53.57Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
53.33Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
51.85Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
51.85Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
51.61Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
51.61Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
51.61Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
50.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
50.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
50.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
50.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.57Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
48.48Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
48.48Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
48.48Consensusbradykinin_onOrthosteric Ligandbk2_on
48.48Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
48.48Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
48.39Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
48.39Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
48.39Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
48.39Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
48.39Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
48.28Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
48.28Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
48.15Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
48.15Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
48.15Consensuscck_onOrthosteric Ligandccka_on cckb_on
48.15Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
48.15Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
48.15Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
47.06Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
46.88Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
46.67Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
46.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.67Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
46.67Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
46.67Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
46.67Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
46.43Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
46.43Single7XN9L-054,5227XN9-SST2-L-054,522
46.43Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
46.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
46.43Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
46.43Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
46.15Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
45.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
45.45Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
45.16Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
45.16Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
45.16Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
45.16Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
44.83Single7F8XNN90567F8X-CCKA-NN9056
44.83Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
44.83Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
44.83Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
44.83Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
44.83Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
44.83Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
44.44Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
44.12Single8IY6Endothelin-18IY6-ETB-Endothelin-1
43.75Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
43.75Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
43.75Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
43.75Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
43.75Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
43.75Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
43.75Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
43.33Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
43.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
43.33Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
43.33Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
43.33Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
42.86Single6IGKEndothelin-36IGK-ETB-Endothelin-3
42.86Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
42.86Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
42.42Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
42.42Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
42.42Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
42.42Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
42.42Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
42.42Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
42.42Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
42.31Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.94Single3OE0CVX153OE0-CXCR4-CVX15
41.94Consensusangiotensin_onOrthosteric Ligandat1_on
41.94Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
41.94Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
41.94Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
41.67Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
41.38Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
41.38Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
41.38Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
41.38Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
41.38Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
41.38Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
41.18Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
41.18Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
40.74Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
40.74Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
40.74Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.74Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
40.74Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
40.62Single6JODAngiotensin II6JOD-AT2-Angiotensin II
40.62Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.62Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
40.62Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
40.62Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
40.62Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
40.62Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
40.62Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.62Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
40.62Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
40.62Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
40.62Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
40.62Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
40.62Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
40.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.00Single6IGLIRL16206IGL-ETB-IRL1620
40.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
40.00Single8XWNCXCL88XWN-CXCR2-CXCL8
40.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
40.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
40.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
40.00Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
40.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
40.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
39.39Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
39.39Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
39.39Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
39.39Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
39.39Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
39.39Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
39.39Single8ZRTET-18ZRT-ETB-ET-1
39.39Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
39.39Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
39.29Single4XEENeurotensin4XEE-NTS1-Neurotensin
39.29Single4XESNeurotensin4XES-NTS1-Neurotensin
39.29Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
39.29Single6OS2TRV0266OS2-AT1-TRV026
39.29Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
39.29Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
39.29Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
39.29Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
39.29Single8XWSCXCL58XWS-CXCR2-CXCL5
39.29Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
39.29Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
39.29Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
39.29Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
39.29Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
39.29Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
39.29Consensusorexin_onOrthosteric Ligandox2_on
38.89Single5GLHEndothelin-15GLH-ETB-Endothelin-1
38.71Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
38.71Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
38.71Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
38.71Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
38.71Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
38.71Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.71Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
38.71Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
38.71Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
38.24Single7SK3CXCL127SK3-ACKR3-CXCL12
38.24Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
38.24Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
37.93Single4BUONeurotensin4BUO-NTS1-Neurotensin
37.93Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
37.93Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
37.93Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
37.93Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
37.93Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
37.93Single8XVUCXCL28XVU-CXCR2-CXCL2
37.93Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
37.93Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
37.93Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
37.93Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.93Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.84Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
37.84Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
37.50Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
37.50Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
37.50Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
37.50Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.50Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
37.50Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
37.50Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
37.50Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
37.14Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
37.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
37.14Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
37.04Single5N2SPSB365N2S-A1-PSB36
37.04Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
37.04Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
36.67Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
36.67Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
36.67Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
36.67Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
36.67Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single8QJ2pN1628QJ2-MC4-pN162-Gs
36.67Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
36.67Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
36.67Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
36.67Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
36.67Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
36.36Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
36.36Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
36.36Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.36Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
36.36Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.36Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.36Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.36Consensusvasop-oxy_onOrthosteric Ligandv2_on
36.36Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
36.11Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
36.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
35.71Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
35.71Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
35.71Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
35.71Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
35.71Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
35.71Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
35.71Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.71Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
35.71Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
35.71Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
35.71Consensusneurotensin_onOrthosteric Ligandnts1_on
35.71Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
35.71Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
35.71Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
35.71Consensusrelaxin_onOrthosteric Ligandrxfp4_on
35.71Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
35.48Single4IARErgotamine4IAR-5-HT1B-Ergotamine
35.48Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
35.48Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
35.48Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
35.48Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
35.48Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
35.48Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
35.48Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
35.29Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
35.29Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
35.29Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
35.29Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
35.29Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
35.29Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
35.29Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
35.29Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
35.14Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
35.14Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
35.14Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
35.14Consensusbombesin_onOrthosteric Ligandbb2_on
35.14Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
35.14Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
35.14Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
34.62Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
34.62Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
34.62Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
34.62Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
34.62Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
34.62Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
34.48Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
34.48Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
34.48Single6MXTSalmeterol6MXT-β2-Salmeterol
34.48Single6YVRNTS8-136YVR-NTS1-NTS8-13
34.48Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
34.48Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.48Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
34.48Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
34.48Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
34.48Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
34.48Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
34.48Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
34.48Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.48Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
34.48Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
34.48Single8XWACXCL18XWA-CXCR2-CXCL1
34.48Single8XWMCXCL68XWM-CXCR2-CXCL6
34.48Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
34.48Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
34.48Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
34.38Single3QAKUK-4320973QAK-A2A-UK-432097
34.38Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
34.38Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
34.38Single7SK5CXCL127SK5-ACKR3-CXCL12
34.38Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
34.38Single7XNACYN1548067XNA-SST2-CYN154806
34.38Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
34.38Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
34.38Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
34.38Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
34.38Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
34.38Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
34.38Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.38Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
34.38Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.38Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
34.29Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
34.29Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
34.21Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
33.33Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
33.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
33.33Single6PT2KGCHM076PT2-δ-KGCHM07
33.33Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
33.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
33.33Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
33.33Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
33.33Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
33.33Single7UM4AS26747237UM4-5-HT5A-AS2674723
33.33Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
33.33Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
33.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
33.33Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
33.33Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
33.33Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
33.33Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XWFCXCL38XWF-CXCR2-CXCL3
33.33Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
33.33Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
33.33Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
33.33Consensuschemerin_onOrthosteric Ligandcml1_on
33.33Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
33.33Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
32.61Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
32.43Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.35Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
32.35Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
32.35Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
32.35Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.35Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
32.35Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.26Single3NY9ICI118-5513NY9-β2-ICI118-551
32.26Single4UG2CGS216804UG2-A2A-CGS21680
32.26Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
32.26Single5WF6UK-4320975WF6-A2A-UK-432097
32.26Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
32.26Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
32.26Single8XQJJN2418XQJ-Apelin-JN241
32.26Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
32.26Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
32.14Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
32.14Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
32.14Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
32.14Single8GNEKW-63568GNE-A2A-KW-6356-Na
32.14Single8QOTNanobody-E8QOT-μ-Nanobody-E
32.14Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
32.14Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
32.14Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
32.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
31.43Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
31.43Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
31.25Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
31.25Single4XT1Fractalkine4XT1-US28-Fractalkine
31.25Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
31.25Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
31.25Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
31.25Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
31.25Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
31.25Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.25Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
31.25Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
31.25Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
31.25Single8WDTphotoNECA8WDT-A2A-photoNECA
31.25Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
31.25Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
31.25Consensussomatostatin_offOrthosteric Ligandsst2_off
31.03Single4BV0Neurotensin4BV0-NTS1-Neurotensin
31.03Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
31.03Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
31.03Single6OS1TRV0266OS1-AT1-TRV026
31.03Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
31.03Single7R0CAVP7R0C-V2-AVP-Arrestin2
31.03Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
31.03Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
31.03Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.03Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.03Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
31.03Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
31.03Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
31.03Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
31.03Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
31.03Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
31.03Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
31.03Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
31.03Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
31.03Consensusa2_onOrthosteric Liganda2b_on
31.03Consensusa2_on_gpOrthosteric Liganda2b_on_gp
31.03Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.03Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.03Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
31.03Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
31.03Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
31.03Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
31.03Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.77Single4BWBNeurotensin4BWB-NTS1-Neurotensin
30.77Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
30.77Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
30.77Single8GNGIstradefylline8GNG-A2A-Istradefylline
30.77Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
30.77Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
30.77Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
30.77Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
30.77Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
30.77Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
30.56Single4XT3Fractalkine4XT3-US28-Fractalkine
30.56Single6FJ3PTH6FJ3-PTH1-PTH
30.56Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
30.30Single6HLOAprepitant6HLO-NK1-Aprepitant
30.30Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
30.30Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.30Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.30Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
30.30Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
30.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
30.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
30.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
30.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
30.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
30.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
30.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
30.00Single8JJLOlodaterol8JJL-β2-Olodaterol
30.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
30.00Single8XQJJN2418XQJ-Apelin-JN241
30.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
30.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
30.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
30.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
30.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
30.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
30.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
30.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
30.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
30.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
30.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
29.73Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
29.63Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
29.63Single6MH8ZM-2413856MH8-A2A-ZM-241385
29.63Single7AROLUF58337ARO-A2A-LUF5833-Na
29.63Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
29.63Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
29.63Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
29.63Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
29.63Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
29.63Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
29.63Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
29.63Consensushca_onOrthosteric Ligandhca2_on
29.63Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
29.63Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
29.41Single5WF5UK-4320975WF5-A2A-UK-432097
29.41Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
29.41Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
29.41Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
29.41Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
29.41Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
29.41Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
29.41Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
29.41Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.03Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
29.03Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
29.03Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
29.03Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
29.03Single6IBLArformoterol6IBL-β1-Arformoterol
29.03Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
29.03Single7EZCUKA7EZC-A2A-UKA
29.03Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
29.03Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
29.03Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
29.03Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
29.03Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
29.03Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
29.03Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.03Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
29.03Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
29.03Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.03Consensusprostanoid_offOrthosteric Ligandep_off dp_off
28.95Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
28.95Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
28.95Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
28.57Single3EMLZM-2413853EML-A2A-ZM-241385
28.57Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
28.57Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
28.57Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
28.57Single6D27CAY104716D27-DP2-CAY10471
28.57Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
28.57Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
28.57Single6S0LZM-2413856S0L-A2A-ZM-241385
28.57Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
28.57Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
28.57Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
28.57Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
28.57Single8CU6LJ-45178CU6-A2A-LJ-4517
28.57Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
28.57Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
28.57Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
28.57Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
28.57Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
28.57Single8K5DGSK2560738K5D-HCA2-GSK256073
28.57Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
28.57Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
28.57Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
28.57Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
28.57Consensusa3_onOrthosteric Liganda3a_on
28.57Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
28.57Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.57Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
28.57Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
28.57Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
28.57Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
28.57Consensushca_on_gpOrthosteric Ligandhca2_on_gp
28.57Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
28.57Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
28.57Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
28.57Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
28.21Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
28.21Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
28.12Single5ZTYAM102575ZTY-CB2-AM10257
28.12Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.12Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
28.12Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
28.12Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
28.12Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.12Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
28.12Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
28.12Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
28.12Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
28.12Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
28.12Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
28.12Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
28.12Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
28.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
27.78Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
27.78Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
27.59Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
27.59Single5C1MBU725C1M-μ-BU72
27.59Single5IUAQ274563485IUA-A2A-Q27456348-Na
27.59Single5N2RPSB-365N2R-A2A-PSB-36-Na
27.59Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
27.59Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.59Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
27.59Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
27.59Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
27.59Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
27.59Single6S0QZM-2413856S0Q-A2A-ZM-241385
27.59Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
27.59Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
27.59Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
27.59Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
27.59Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
27.59Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
27.59Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
27.59Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
27.59Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
27.59Single7W41PD1762527W41-BB2-PD176252
27.59Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
27.59Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.59Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
27.59Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
27.59Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
27.59Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
27.59Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
27.59Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
27.59Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
27.59Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
27.59Single8TF5Oleic acid8TF5-GPR6-Oleic acid
27.59Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
27.59Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
27.59Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
27.59Consensusa3_on_gpOrthosteric Liganda3a_on_gp
27.59Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.59Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.59Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.59Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.59Consensusbombesin_offOrthosteric Ligandbb2_off
27.59Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.59Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
27.59Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
27.59Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
27.59Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
27.59Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
27.59Consensusdp_offOrthosteric Liganddp2_off
27.59Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
27.59Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
27.59Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
27.27Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
27.27Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
27.27Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.27Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
27.27Single8WKYPG-9348WKY-MC4-PG-934
27.27Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
27.27Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
27.27Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.27Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
27.27Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
27.27Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
27.27Consensuslpl_onOrthosteric Ligands1p_on lpa_on
27.27Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
27.03Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
27.03Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
27.03Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
26.92Single3OE9IT1t3OE9-CXCR4-IT1t
26.92Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
26.92Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
26.92Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
26.92Single8K5BNiacin8K5B-HCA2-Niacin
26.92Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
26.67Single3P0GBI1671073P0G-β2-BI167107
26.67Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.67Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
26.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
26.67Single5D5AS-Carazolol5D5A-β2-S-Carazolol
26.67Single5D5BS-Carazolol5D5B-β2-S-Carazolol
26.67Single5XR8AM8415XR8-CB1-AM841
26.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.67Single6J20Aprepitant6J20-NK1-Aprepitant
26.67Single6J21Aprepitant6J21-NK1-Aprepitant
26.67Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
26.67Single6WGTLSD6WGT-5-HT2A-LSD
26.67Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
26.67Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
26.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
26.67Single7PX4PSB-21137PX4-A2A-PSB-2113
26.67Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
26.67Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.67Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
26.67Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
26.67Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
26.67Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
26.67Single8E0GBU728E0G-μ-BU72
26.67Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
26.67Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
26.67Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
26.67Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
26.67Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
26.67Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
26.67Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
26.67Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.67Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
26.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.67Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.67Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.67Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.67Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.67Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
26.67Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensustachykinin_offOrthosteric Ligandnk1_off
26.47Single8IEBA1LYA8IEB-GPR156-A1LYA
26.47Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.47Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.32Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
26.32Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
26.32Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
25.93Single3PWHZM-2413853PWH-A2A-ZM-241385
25.93Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
25.93Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.93Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.93Single5ZKQABT-4915ZKQ-PAF-ABT-491
25.93Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
25.93Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
25.93Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
25.93Single7F8ULintitript7F8U-CCKA-Lintitript
25.93Single7F8YDevazepide7F8Y-CCKA-Devazepide
25.93Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
25.93Single7XRRLemborexant7XRR-OX2-Lemborexant
25.93Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
25.93Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
25.93Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
25.93Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
25.93Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.93Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.93Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
25.93Consensusorexin_offOrthosteric Ligandox2_off ox1_off
25.93Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
25.93Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
25.93Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
25.81Single3D4STimolol3D4S-β2-Timolol
25.81Single4AMIBucindolol4AMI-β1-Bucindolol
25.81Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
25.81Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.81Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
25.81Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.81Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
25.81Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
25.81Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
25.81Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
25.81Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.81Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.81Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
25.81Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.81Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.81Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
25.81Single7YITNalfurafine7YIT-κ-Nalfurafine
25.81Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
25.81Single8JJ8Formoterol8JJ8-β2-Formoterol
25.81Single8JWY2-1188JWY-A2A-2-118
25.81Single8JWZAB9288JWZ-A2A-AB928-Na
25.81Single8XYIVUF106618XYI-CXCR3-VUF10661
25.81Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.81Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
25.81Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.81Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.81Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
25.81Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
25.81Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.81Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
25.81Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.81Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
25.81Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.81Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.81Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
25.81Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.81Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.81Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
25.81Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.81Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.71Single6W25SHU91196W25-MC4-SHU9119-Ca
25.71Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
25.64Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
25.00Single3REYXAC3REY-A2A-XAC
25.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
25.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
25.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
25.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
25.00Single5JTBZM-2413855JTB-A2A-ZM-241385
25.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
25.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
25.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
25.00Single5UVIZM-2413855UVI-A2A-ZM-241385
25.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
25.00Single6H7LDobutamine6H7L-β1-Dobutamine
25.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
25.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
25.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
25.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
25.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
25.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
25.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
25.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
25.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7UL3Famotidine7UL3-H2-Famotidine
25.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
25.00Single7VV6C48/807VV6-MRGPRX2-C48/80
25.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
25.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
25.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
25.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
25.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.00Single8IHKAcifran8IHK-HCA3-Acifran
25.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
25.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
25.00Single8K5CAcipimox8K5C-HCA2-Acipimox
25.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
25.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
25.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
25.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
25.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
25.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
25.00Consensusa2_offOrthosteric Liganda2a_off
25.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
25.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
25.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Consensusgrh_offOrthosteric Ligandgnrh1_off
25.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
24.44Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
24.39Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
24.39Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
24.39Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
24.32Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
24.32Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
24.32Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
24.24Single6KNMJN241-96KNM-Apelin-JN241-9
24.24Single6PT3DPI-2876PT3-δ-DPI-287
24.24Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
24.24Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.24Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
24.24Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
24.24Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
24.24Single8X5YAstemizole8X5Y-H1-Astemizole
24.14Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
24.14Single2Y02Carmoterol2Y02-β1-Carmoterol
24.14Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
24.14Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
24.14Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
24.14Single4EJ4Naltrindole4EJ4-δ-Naltrindole
24.14Single4QIMANTA XV4QIM-SMO-ANTA XV
24.14Single4QKX35V4QKX-β2-35V
24.14Single5IU8Q274563475IU8-A2A-Q27456347-Na
24.14Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
24.14Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
24.14Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
24.14Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
24.14Single5T04Neurotensin5T04-NTS1-Neurotensin
24.14Single5UENDU1725UEN-A1-DU172
24.14Single5UIGCmpd-15UIG-A2A-Cmpd-1
24.14Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
24.14Single6PS1Timolol6PS1-β2-Timolol
24.14Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
24.14Single6TOTLemborexant6TOT-OX1-Lemborexant
24.14Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
24.14Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
24.14Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
24.14Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
24.14Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
24.14Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
24.14Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
24.14Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
24.14Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
24.14Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
24.14Single7PYRPSB-21157PYR-A2A-PSB-2115
24.14Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
24.14Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
24.14Single7UL4Alvimopan7UL4-μ-Alvimopan
24.14Single7V3ZCP559407V3Z-CB1-CP55940
24.14Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
24.14Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
24.14Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
24.14Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
24.14Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
24.14Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
24.14Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
24.14Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
24.14Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
24.14Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
24.14Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
24.14Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
24.14Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
24.14Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
24.14Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single9CHXS-Carazolol9CHX-β2-S-Carazolol
24.14Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
24.14Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.14Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.14Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
24.14Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
24.14Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
24.14Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
24.14Consensuscck_offOrthosteric Ligandccka_off
24.14Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
24.14Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
24.14Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
24.14Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
24.14Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
24.14Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
23.81Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
23.81Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.68Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.68Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
23.68Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
23.53Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
23.53Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8IEPA1LYA8IEP-GPR156-A1LYA
23.53Single8IEPA1LYA8IEP-GPR156-A1LYA
23.53Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
23.53Single8KIGSHU91198KIG-MC3-SHU9119-Ca
23.53Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
23.53Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
23.53Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.53Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.53Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.53Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
23.33Single2RH1S-Carazolol2RH1-β2-S-Carazolol
23.33Single2YCWS-Carazolol2YCW-β1-S-Carazolol
23.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
23.33Single5D6LS-Carazolol5D6L-β2-S-Carazolol
23.33Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
23.33Single5TVNLSD5TVN-5-HT2B-LSD
23.33Single5WIUNemonapride5WIU-D4-Nemonapride
23.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.33Single5WQCEMPA5WQC-OX2-EMPA
23.33Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
23.33Single6E67BI1671076E67-β2-BI167107-Gs (fused)
23.33Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
23.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
23.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.33Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
23.33Single6TP6Filorexant6TP6-OX1-Filorexant
23.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
23.33Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
23.33Single6Z4SSR486926Z4S-NTS1-SR48692
23.33Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
23.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
23.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
23.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
23.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.33Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
23.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
23.33Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.33Single7WC6LSD7WC6-5-HT2A-LSD
23.33Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
23.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
23.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
23.33Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
23.33Single8JXSPF-61428JXS-D1-PF-6142
23.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.33Single8S4DCMF-0198S4D-Apelin-CMF-019
23.33Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
23.33Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
23.33Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
23.33Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
23.33Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
23.33Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.33Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
23.33Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
23.33Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
23.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
23.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
23.33Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
23.33Consensusamine_offonOrthosteric Ligandamine_off amine_on
23.33Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
23.33Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
23.33Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
23.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
23.33Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.33Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.33Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.33Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.33Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.33Consensustrace-amine_onOrthosteric Ligandta1_on
23.26Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.26Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
23.26Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single3OE6IT1t3OE6-CXCR4-IT1t
23.08Single4XNWMRS25004XNW-P2Y1-MRS2500
23.08Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
23.08Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
23.08Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
23.08Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
23.08Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.08Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
23.08Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
22.86Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.86Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.86Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.86Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.58Single2YDVNECA2YDV-A2A-NECA
22.58Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
22.58Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
22.58Single4UHRCGS216804UHR-A2A-CGS21680
22.58Single5G53NECA5G53-A2A-NECA-Gs
22.58Single5V56TC1145V56-SMO-TC114
22.58Single5XRAAM115425XRA-CB1-AM11542
22.58Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
22.58Single6E59L-7607356E59-NK1-L-760735
22.58Single6H7JIsoprenaline6H7J-β1-Isoprenaline
22.58Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
22.58Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
22.58Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.58Single6TQ7SB-3348676TQ7-OX1-SB-334867
22.58Single7B6WCyclazosin7B6W-α1b-Cyclazosin
22.58Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
22.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.58Single7F1TMIP-1a7F1T-CCR5-MIP-1a
22.58Single7FEECP559407FEE-CB1-CP55940-ZCZ011
22.58Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
22.58Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
22.58Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
22.58Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
22.58Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
22.58Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
22.58Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
22.58Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
22.58Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.58Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
22.58Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
22.58Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
22.58Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
22.58Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.58Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.58Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
22.58Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
22.58Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.58Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.58Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
22.58Consensuslpa_onOrthosteric Ligandlpa1_on
22.58Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
22.58Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
22.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.58Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.58Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
22.50Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
22.50Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
22.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
22.50Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
22.22Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
22.22Single6HLLCP999946HLL-NK1-CP99994
22.22Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
22.22Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
22.22Single7UL2SR486927UL2-NTS1-SR48692-Na
22.22Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.22Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
22.22Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
22.22Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
22.22Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
22.22Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
22.22Consensusgq_nucleotideOrthosteric Ligandgq_p2y
22.22Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.22Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusneurotensin_offOrthosteric Ligandnts1_off
22.22Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
21.88Single4LDEBI1671074LDE-β2-BI167107
21.88Single4PY02MeSATP4PY0-P2Y12-2MeSATP
21.88Single6KQICP559406KQI-CB1-CP55940-Org27569
21.88Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.88Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.88Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
21.88Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.88Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.88Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
21.88Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
21.88Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.88Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
21.88Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
21.88Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
21.88Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
21.88Consensuslpa_offOrthosteric Ligandlpa1_off
21.88Consensuslpl_offOrthosteric Ligands1p_off lpa_off
21.88Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.88Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.88Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.62Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
21.62Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.62Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
21.43Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single3ODUIT1t3ODU-CXCR4-IT1t
21.43Single5WS3EMPA5WS3-OX2-EMPA
21.43Single6AKXA4R6AKX-CCR5-A4R
21.43Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.43Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
21.43Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.43Single6TODEMPA6TOD-OX1-EMPA-Na
21.43Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
21.43Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.43Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
21.43Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
21.43Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.43Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
21.43Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.43Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
21.43Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
21.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.43Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
21.43Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.43Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.43Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
21.43Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
21.43Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
21.43Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
21.43Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
21.43Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
21.43Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
21.43Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
21.43Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
21.43Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
21.43Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.43Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.43Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
21.21Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
21.21Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
21.21Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
21.21Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
21.21Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
21.21Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
21.21Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.21Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
21.21Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.21Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
21.21Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
21.21Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.21Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
21.21Consensusendothelin_offOrthosteric Ligandetb_off
21.21Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
21.05Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
21.05Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.05Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
21.05Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.93Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.93Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
20.69Single2YDOAdenosine2YDO-A2A-Adenosine
20.69Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
20.69Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.69Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
20.69Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
20.69Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
20.69Single6AQFZM-2413856AQF-A2A-ZM-241385
20.69Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.69Single6PS0S-Carazolol6PS0-β2-S-Carazolol
20.69Single6PS4ICI118-5516PS4-β2-ICI118-551
20.69Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
20.69Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.69Single6TPGEMPA6TPG-OX2-EMPA
20.69Single6V9SGTPL114036V9S-OX1-GTPL11403
20.69Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.69Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
20.69Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
20.69Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.69Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
20.69Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
20.69Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
20.69Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
20.69Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.69Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
20.69Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.69Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
20.69Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
20.69Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
20.69Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
20.69Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
20.69Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.69Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
20.69Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.69Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
20.69Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
20.69Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
20.69Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
20.69Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.69Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
20.69Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.59Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.59Single8IEIA1LYA8IEI-GPR156-A1LYA
20.59Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.59Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.51Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.51Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.51Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.00Single3NY8ICI118-5513NY8-β2-ICI118-551
20.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
20.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
20.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
20.00Single4YAYZD-71554YAY-AT1-ZD-7155
20.00Single5DHGC-355DHG-NOP-C-35
20.00Single5DHHSB-6121115DHH-NOP-SB-612111
20.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
20.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6H7MSalbutamol6H7M-β1-Salbutamol
20.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
20.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
20.00Single7BU7BI1671077BU7-β1-BI167107
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
20.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
20.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
20.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
20.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
20.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
20.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
20.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
20.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8IEIA1LYA8IEI-GPR156-A1LYA
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8JJOAlprenolol8JJO-β2-Alprenolol
20.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
20.00Single8RLNLUF58348RLN-A2A-LUF5834
20.00Single8T1WCVN4248T1W-GPR6-CVN424
20.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
20.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
20.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
20.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
20.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
20.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
20.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
20.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
20.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
20.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusblt_onOrthosteric Ligandblt1_on
20.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
20.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
20.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
20.00Consensusleukotriene_onOrthosteric Ligandblt_on
20.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
19.51Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
19.51Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
19.51Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
19.51Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
19.51Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
19.44Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.35Single2Y03Isoprenaline2Y03-β1-Isoprenaline
19.35Single4JKVTaladegib4JKV-SMO-Taladegib
19.35Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.35Single5JQHS-Carazolol5JQH-β2-S-Carazolol
19.35Single6HLPNetupitant6HLP-NK1-Netupitant
19.35Single6PS6Timolol6PS6-β2-Timolol
19.35Single7C4SS1P7C4S-S1P3-S1P
19.35Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
19.35Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
19.35Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
19.35Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.35Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
19.35Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
19.35Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
19.35Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
19.35Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
19.35Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
19.35Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
19.35Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.35Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
19.35Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
19.35Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
19.35Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
19.35Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.35Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
19.23Single3RFMCaffeine3RFM-A2A-Caffeine
19.23Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
19.23Single6TQ9SB-4081246TQ9-OX1-SB-408124
19.23Single8A2OTheophylline8A2O-A2A-Theophylline-Na
19.23Consensusp2y_offOrthosteric Ligandp2y1_off
19.05Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
18.92Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.75Single4DJHJDTic4DJH-κ-JDTic
18.75Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
18.75Single5V57TC1145V57-SMO-TC114
18.75Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
18.75Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
18.75Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
18.75Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
18.75Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
18.75Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
18.75Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
18.75Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
18.75Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
18.75Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
18.75Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.75Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
18.75Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
18.75Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
18.75Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
18.75Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.60Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
18.52Single6ME5Agomelatine6ME5-MT1-Agomelatine
18.52Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
18.52Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
18.52Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
18.52Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.52Consensus5ht2_onOrthosteric Ligand5ht2b_on
18.52Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.42Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
18.42Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
18.42Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
18.18Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.18Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
18.18Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
18.18Single6A93Risperidone6A93-5-HT2A-Risperidone
18.18Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
18.18Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.18Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
18.18Single6ZG4HTL00099366ZG4-M1-HTL0009936
18.18Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
18.18Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
18.18Single7K15MKD0467K15-BLT1-MKD046-Na
18.18Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
18.18Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
18.18Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.18Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
18.18Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
18.18Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
18.18Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
18.18Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.18Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.95Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.86Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
17.86Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
17.86Single7SRQLSD7SRQ-5-HT2B-LSD
17.86Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
17.86Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
17.86Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.86Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
17.86Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
17.86Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
17.86Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
17.86Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
17.86Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.86Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.86Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
17.86Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
17.86Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
17.86Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.86Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.65Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.65Single5X93K-87945X93-ETB-K-8794
17.65Single6K1QIRL25006K1Q-ETB-IRL2500
17.65Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
17.65Single8XVJMacitentan8XVJ-ETA-Macitentan
17.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.39Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.24Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
17.24Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
17.24Single4S0VSuvorexant4S0V-OX2-Suvorexant
17.24Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.24Single6B73MP11046B73-κ-MP1104
17.24Single6DS0Ly2660976DS0-5-HT2B-Ly266097
17.24Single6ME2Ramelteon6ME2-MT1-Ramelteon
17.24Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.24Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
17.24Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
17.24Single6TPJSuvorexant6TPJ-OX2-Suvorexant
17.24Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
17.24Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
17.24Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
17.24Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
17.24Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
17.24Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
17.24Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
17.24Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
17.24Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
17.24Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
17.24Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
17.24Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
17.24Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
17.24Single8IWESpermidine8IWE-TA9-Spermidine
17.24Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
17.24Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
17.24Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
17.24Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
17.24Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
17.24Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
17.24Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
17.24Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
17.24Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.24Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
17.24Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
17.24Consensusalpha2_offOrthosteric Ligandalpha2c_off
17.24Consensusangiotensin_offOrthosteric Ligandat1_off
17.24Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.24Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.24Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.24Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
17.24Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.24Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
17.14Single5EE7MK08935EE7-Glucagon-MK0893
17.14Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
17.14Single7SK9CCX6627SK9-ACKR3-CCX662
17.07Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.07Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.67Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
16.67Single6A94Zotepine6A94-5-HT2A-Zotepine
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
16.67Single6KUXRS-799486KUX-α2a-RS-79948
16.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.67Single6TPKRetosiban6TPK-OT-Retosiban
16.67Single6TPNHTL66416TPN-OX2-HTL6641
16.67Single6VI4JDTic6VI4-κ-JDTic
16.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
16.67Single6ZG9GSK10347026ZG9-M1-GSK1034702
16.67Single6ZINSR486926ZIN-NTS1-SR48692
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
16.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
16.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
16.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
16.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.67Single7T32ZM-2413857T32-A2A-ZM-241385
16.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
16.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
16.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
16.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
16.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
16.67Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
16.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
16.67Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
16.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
16.67Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
16.67Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
16.67Consensusalpha1_onOrthosteric Ligandalpha1a_on
16.67Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
16.67Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
16.67Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
16.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
16.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
16.67Consensusvasop-oxy_offOrthosteric Ligandot_off
16.33Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
16.28Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
16.22Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
16.22Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
16.22Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
16.22Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.13Single2Y04Salbutamol2Y04-β1-Salbutamol
16.13Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
16.13Single6DRXLisuride6DRX-5-HT2B-Lisuride
16.13Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
16.13Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
16.13Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
16.13Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
16.13Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
16.13Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
16.13Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
16.13Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
16.13Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
16.13Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
16.13Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
16.13Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
16.13Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
16.13Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
16.13Single8JXRLSD8JXR-D1-LSD
16.13Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
16.13Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.13Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
16.13Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
16.13Single8X63Mepyramine8X63-H1-Mepyramine
16.13Single8X64Desloratadine8X64-H1-Desloratadine
16.13Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
16.13Single9IYAONO-97105319IYA-GPR55-ONO-9710531
16.13Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
16.13Consensusalpha2_onOrthosteric Ligandalpha2b_on
16.13Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
16.13Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
16.13Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
16.13Consensushistamine_offOrthosteric Ligandh1_off
16.13Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
16.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
16.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
15.91Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.62Single2Y00Dobutamine2Y00-β1-Dobutamine
15.62Single5XPRBosentan5XPR-ETB-Bosentan
15.62Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.62Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.62Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
15.62Single6LUQHaloperidol6LUQ-D2-Haloperidol
15.62Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.62Single7SINNPS-21437SIN-CaS-NPS-2143
15.62Single7SINNPS-21437SIN-CaS-NPS-2143
15.62Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
15.62Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
15.62Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
15.62Single8ZMFA1L108ZMF-5-HT2C-A1L10
15.62Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
15.62Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
15.62Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
15.62Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
15.62Consensusblt_offOrthosteric Ligandblt1_off
15.62Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.62Consensusep_offOrthosteric Ligandep4_off
15.62Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
15.62Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
15.38Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
15.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.38Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
15.38Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
15.38Single8PWNTheophylline8PWN-A2A-Theophylline
15.38Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
15.22Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
15.22Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
15.22Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
15.22Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
15.15Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
15.15Single4U15Tiotropium4U15-M3-Tiotropium
15.15Single5TZRMK86665TZR-FFA1-MK8666
15.15Single5V54Methiothepin5V54-5-HT1B-Methiothepin
15.15Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
15.15Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
15.15Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.15Single6OL9Tiotropium6OL9-M5-Tiotropium
15.15Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
15.15Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
15.15Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
15.15Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
15.15Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.15Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
15.15Single8XVLZibotentan8XVL-ETA-Zibotentan
15.15Consensus5ht1_offOrthosteric Ligand5ht1b_off
15.15Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
15.15Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
15.15Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
15.15Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
15.15Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.81Single3OE8IT1t3OE8-CXCR4-IT1t
14.81Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
14.81Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
14.71Single4N4WSANT-14N4W-SMO-SANT-1
14.71Single5CXVTiotropium5CXV-M1-Tiotropium
14.71Single6CM4Risperidone6CM4-D2-Risperidone
14.71Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
14.71Single7DFPSpiperone7DFP-D2-Spiperone
14.71Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
14.71Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
14.71Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
14.71Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
14.71Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
14.71Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
14.29Single3UZAGTPL92363UZA-A2A-GTPL9236
14.29Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
14.29Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
14.29Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
14.29Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
14.29Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
14.29Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
14.29Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
14.29Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
14.29Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
14.29Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
14.29Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.95Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
13.79Single3PBLEticlopride3PBL-D3-Eticlopride
13.79Single4O9RCyclopamine4O9R-SMO-Cyclopamine
13.79Single5L7IVismodegib5L7I-SMO-Vismodegib
13.79Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.79Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
13.79Single6TP4ACT-4622066TP4-OX1-ACT-462206
13.79Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.79Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
13.79Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
13.79Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
13.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.79Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
13.79Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
13.79Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
13.79Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
13.79Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
13.79Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
13.79Single9B9Y7DY9B9Y-CB1-7DY
13.79Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
13.79Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
13.64Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
13.51Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.33Single4QINSAG1.54QIN-SMO-SAG1.5
13.33Single5U09Taranabant5U09-CB1-Taranabant
13.33Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
13.33Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
13.33Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
13.33Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.33Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
13.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
13.33Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
13.33Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
13.33Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
13.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
13.33Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
13.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
13.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.33Single8Y0HVUF114188Y0H-CXCR3-VUF11418
13.33Single9BA0A1AKN9BA0-CB1-A1AKN
13.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
13.33Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
13.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.33Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.33Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.90Single3RZECidoxepin3RZE-H1-Cidoxepin
12.90Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
12.90Single6IQLL7458706IQL-D4-L745870
12.90Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
12.90Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
12.90Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.90Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
12.90Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
12.90Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
12.90Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
12.90Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.90Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
12.90Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
12.90Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
12.90Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
12.90Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.90Single9BJKNaloxone9BJK-μ-Naloxone-NAM
12.90Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
12.90Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
12.50Single2Y01Dobutamine2Y01-β1-Dobutamine
12.50Single4DAJTiotropium4DAJ-M3-Tiotropium
12.50Single4MQSIperoxo4MQS-M2-Iperoxo
12.50Single4U14Tiotropium4U14-M3-Tiotropium
12.50Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
12.50Single5TGZAM65385TGZ-CB1-AM6538
12.50Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
12.50Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
12.50Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
12.50Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
12.50Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
12.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.50Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.50Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
12.50Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.50Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
12.50Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.50Single9B9ZA1AKO9B9Z-CB1-A1AKO
12.50Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
12.50Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.50Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.20Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.20Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
12.12Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
12.12Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
12.12Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
12.12Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
12.12Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
12.12Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
12.12Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
12.12Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
12.12Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
11.76Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.76Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
11.76Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
11.76Single8EA0Iperoxo8EA0-M3-Iperoxo
11.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
11.76Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
11.76Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
11.76Single9BJKNAM9BJK-μ-Naloxone-NAM
11.76Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.76Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
11.63Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
11.63Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
11.54Single5MZPCaffeine5MZP-A2A-Caffeine-Na
11.43Single5X33BIIL2605X33-BLT1-BIIL260
11.43Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
11.43Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
11.43Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.36Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.36Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
11.36Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
11.11Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
11.11Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
11.11Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
11.11Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
11.11Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
11.11Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
11.11Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
10.81Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.81Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
10.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.71Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.71Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
10.71Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
10.71Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
10.71Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
10.71Single9CHUNoradrenaline9CHU-β2-Noradrenaline
10.71Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.71Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.71Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
10.71Consensussensory_onOrthosteric Ligandopsins_on
10.53Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
10.34Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.34Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.34Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.34Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
10.34Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.34Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
10.34Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
10.34Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.34Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.34Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.34Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.34Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.34Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.34Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
10.34Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.34Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
10.34Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
10.34Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.34Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.34Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.34Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.34Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.34Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.34Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.34Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.34Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.34Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.34Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.00Single6LI0C176LI0-GPR52-C17
10.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
10.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
10.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.76Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
9.68Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.68Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.68Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.68Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.68Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.68Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.68Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
9.68Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.68Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
9.68Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
9.68Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
9.68Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.68Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
9.68Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
9.68Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
9.68Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.68Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
9.68Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
9.68Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
9.38Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
9.38Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.38Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.38Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.38Single8K2WAMG4878K2W-CXCR3-AMG487
9.38Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
9.38Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.38Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
9.38Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
9.09Single5DSGTiotropium5DSG-M4-Tiotropium
9.09Single6GPSMK08126GPS-CCR2-MK0812
9.09Single6IIVDaltroban6IIV-TP-Daltroban
9.09Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
9.09Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.09Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
9.09Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
9.09Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
9.09Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
8.82Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
8.82Single5CGCHTL142425CGC-mGlu5-HTL14242
8.82Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.82Single6GPXMK08126GPX-CCR2-MK0812
8.82Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.82Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.82Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
8.82Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.82Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.82Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.82Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.82Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.82Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.57Single7P2L4YI7P2L-mGlu5-4YI
8.57Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.57Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.57Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
8.57Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
8.33Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.33Single6IIURamatroban6IIU-TP-Ramatroban
8.33Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
8.33Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.11Single5CGDHTL142425CGD-mGlu5-HTL14242
7.41Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
7.41Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
7.41Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
7.14Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
7.14Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.14Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.14Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.90Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.90Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.90Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
6.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
6.67Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
6.67Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
6.67Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
6.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
6.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.45Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
6.45Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.45Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.45Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.45Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.45Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.45Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
6.25Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
6.25Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
6.25Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
6.25Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
6.25Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
6.25Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.06Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
6.06Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
6.06Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
6.06Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
6.06Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
6.06Consensusopsins_offOrthosteric Ligandrhodopsin_off
6.06Consensussensory_offOrthosteric Ligandopsins_off
5.88Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
5.71Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.71Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.71Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.71Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.71Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.56Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
5.56Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
5.56Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
5.26Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
5.13Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
5.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
4.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.00Single6D35Cholesterol6D35-SMO-Cholesterol
4.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.00Single7DTTCa7DTT-CaS-Ca-Ca
4.00Single7DTTCa7DTT-CaS-Ca-Ca
4.00Single7DTUTryptophan7DTU-CaS-Tryptophan
4.00Single7DTUTryptophan7DTU-CaS-Tryptophan
4.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
4.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.00Single7XW7K1-707XW7-TSH-K1-70
4.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8WVXNorrin8WVX-LGR4-Norrin
4.00Single8WVYNorrin8WVY-LGR4-Norrin
4.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.85Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.85Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.85Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.85Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.85Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.70Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.70Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.57Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
3.57Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
3.57Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.57Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.57Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
3.57Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.57Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.45Single5L7DCholesterol5L7D-SMO-Cholesterol
3.45Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.45Single8HS2Fab0468HS2-GPR20-Fab046
3.45Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.45Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.45Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
3.23Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.23Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.12Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
3.12Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
3.12Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
3.12Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
3.12Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
3.12Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.03Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
3.03Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
3.03Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
3.03Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
3.03Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
3.03Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
2.94Single6FFIMMPEP6FFI-mGlu5-MMPEP
2.86Single6FFHFenobam6FFH-mGlu5-Fenobam
2.86Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.78Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.70Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
2.63Single7SHEPI; PE7SHE-GPR158-PI; PE
2.56Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.50Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
2.44Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.44Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.38Single7SHEPI; PE7SHE-GPR158-PI; PE
2.38Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.33Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.33Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.27Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.13Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
npy1_on_gp 8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
npy2_on_gp 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
npy4_on_gp 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
Net Summary
Imin 2.1
Number of Linked Nodes 879
Number of Links 1171
Number of Hubs 209
Number of Links mediated by Hubs 779
Number of Communities 28
Number of Nodes involved in Communities 287
Number of Links involved in Communities 446
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 1396042
Length Of Smallest Path 3
Average Path Length 23.3485
Length of Longest Path 54
Minimum Path Strength 0.456667
Average Path Strength 4.6664
Maximum Path Strength 28.3633
Minimum Path Correlation 0.7
Average Path Correlation 0.979004
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 48.2328
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.4986
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
npy_off_on_gpnpy_on_gpnpy_off
This network is also present in following consensuses:
IdComponents
peptide_on_gpcck_on_gp
angiotensin_on_gp
apelin_on_gp
bombesin_on_gp
bradykinin_on_gp
compl-peptide_on_gp
endothelin_on_gp
formylpeptide_on_gp
galanin_on_gp
ghrelin_on_gp
kisspeptin_on_gp
melanocortin_on_gp
motilin_on_gp
neuromedin-u_on_gp
npy_on_gp
neurotensin_on_gp
opioid_on_gp
orexin_on_gp
relaxin_on_gp
somatostatin_on_gp
tachykinin_on_gp
trh_on_gp
vasop-oxy_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download npy_on_gp.zip



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