Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:K53 4.432509
2A:A:F212 8.5625409
3A:A:F219 7.818508
4A:A:H220 12.7475427
5A:A:F222 14.1175427
6A:A:R231 5.92559
7A:A:W234 6.854559
8A:A:I235 5.44459
9A:A:F238 10.3325409
10A:A:F246 4.42459
11A:A:L270 5.6075406
12A:A:D272 5.59458
13A:A:F273 4.34759
14A:A:W277 7.56656
15A:A:W281 9.764525
16A:A:L289 4.042559
17A:A:F290 5.991676169
18A:A:F312 4.6625198
19A:A:F315 9.406506
20A:A:R336 6.814505
21A:A:F340 8.46754197
22A:A:F345 5.78458
23A:A:S349 4.1325457
24A:A:C359 4.5075455
25A:A:Y360 9.254598
26A:A:T364 7.7754169
27A:A:C365 6.2425408
28A:A:R373 5.03254155
29A:A:F376 6.523336158
30A:A:I383 4.4575408
31A:A:L388 5.0554218
32A:A:Y391 9.0225444
33B:B:R22 5.5025406
34B:B:H54 9.188336109
35B:B:K57 12.1375429
36B:B:Y59 12.4325428
37B:B:W63 6.562507
38B:B:D76 5.5465109
39B:B:L79 5.52754117
40B:B:I80 8.96754108
41B:B:W82 11.8665109
42B:B:Y85 12.24254124
43B:B:K89 7.3056109
44B:B:H91 6.45405
45B:B:I93 6.14754117
46B:B:L95 4.5325118
47B:B:W99 9.428529
48B:B:Y105 4.50667606
49B:B:N110 6.8175414
50B:B:Y111 7.066514
51B:B:Y124 5.35258116
52B:B:V133 5.7554114
53B:B:H142 7.67619
54B:B:C149 5.095418
55B:B:F151 5.28286719
56B:B:I157 5.41417
57B:B:T159 6.398519
58B:B:S160 5.575406
59B:B:S161 6.7375419
60B:B:D163 7.4425419
61B:B:C166 4.585478
62B:B:W169 8.57667618
63B:B:D170 7.195419
64B:B:I171 3.5075416
65B:B:Q176 5.645414
66B:B:F180 9.034577
67B:B:H183 7.70667679
68B:B:F199 8.585679
69B:B:D205 5.75479
70B:B:K209 9.8575476
71B:B:L210 5.325405
72B:B:W211 10.706578
73B:B:D212 4.715409
74B:B:Q220 8.695437
75B:B:F222 9.445438
76B:B:H225 7.48286739
77B:B:D228 8.895439
78B:B:I232 6.2475438
79B:B:F234 6.715405
80B:B:F235 7.3985176
81B:B:F241 8.682536
82B:B:T243 7.0225438
83B:B:D246 7.625439
84B:B:D247 7.2225439
85B:B:R251 11.5317638
86B:B:F253 8.624536
87B:B:D254 3.998509
88B:B:R256 7.29409
89B:B:D258 10.23437
90B:B:M262 6.0825404
91B:B:Y264 7.622505
92B:B:F278 3.826507
93B:B:R283 8.45409
94B:B:L285 4.295406
95B:B:Y289 7.00571727
96B:B:D290 7.11426
97B:B:C294 4.295485
98B:B:V296 4.295405
99B:B:W297 8.1725428
100B:B:L300 5.27406
101B:B:K301 5.79754225
102B:B:R304 6.592525
103B:B:H311 8.336589
104B:B:R314 12.258528
105B:B:M325 6.7875405
106B:B:W332 11.2113829
107B:B:D333 7.99489
108B:B:K337 6.37406
109B:B:W339 10.5275409
110G:G:R27 5.98408
111G:G:Y40 8.7454176
112G:G:D48 8.3975409
113G:G:L51 4.526506
114G:G:F61 6.338577128
115L:L:?1 9.535831260
116R:R:V23 4.3875401
117R:R:L52 4.264258
118R:R:F61 10.5125448
119R:R:Y64 8.63508
120R:R:L68 4.9675449
121R:R:F75 4.8685136
122R:R:M79 6.0285135
123R:R:R103 6.618564
124R:R:F107 5.2525145
125R:R:Y109 7.5575408
126R:R:L116 5.755449
127R:R:Q122 7.4125449
128R:R:R123 6.275449
129R:R:L128 5.874186
130R:R:F133 7.0775447
131R:R:R137 7.33449
132R:R:W150 6.62754149
133R:R:C153 5.19754148
134R:R:N157 7.52254147
135R:R:F163 7.165404
136R:R:C164 5.0975466
137R:R:D179 10.8275463
138R:R:W204 4.6354186
139R:R:W212 11.518593
140R:R:P216 4.41497
141R:R:L219 5.9875407
142R:R:F230 6.192549
143R:R:Y240 7.5475403
144R:R:Y245 6.442564
145R:R:R262 7.74404
146R:R:S268 3.985409
147R:R:Y276 5.12333649
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 73.03747.15NoNo085
2B:B:D66 B:B:L69 72.9054.07NoNo085
3B:B:L69 B:B:Y105 72.77253.52NoYes056
4A:A:D27 A:A:R31 12.08539.53NoNo063
5B:B:R68 B:B:Y85 66.090624.69NoYes054
6A:A:E35 A:A:R31 12.01571.16NoNo043
7A:A:E35 R:R:R139 11.98711.16NoNo045
8R:R:H140 R:R:R139 11.961919.18NoNo055
9R:R:H140 R:R:W144 11.93923.17NoNo055
10R:R:P138 R:R:W144 11.92032.7NoNo085
11R:R:L141 R:R:P138 11.90458.21NoNo058
12R:R:L141 R:R:R137 11.89274.86NoYes059
13A:A:F290 A:A:T364 10.25297.78YesYes1699
14B:B:Q75 B:B:W99 1004.38NoYes299
15B:B:K57 B:B:Q75 49.99185.42YesNo299
16B:B:K57 B:B:W332 49.866817.4YesYes299
17A:A:W281 B:B:W332 48.23764.69YesYes259
18A:A:W281 B:B:D290 48.17796.7YesYes256
19B:B:C271 B:B:D290 96.21653.11NoYes256
20B:B:C271 B:B:D291 81.37567.78NoNo258
21B:B:D291 B:B:N293 81.41769.42NoNo085
22B:B:N293 B:B:V307 81.14474.43NoNo053
23B:B:G306 B:B:V307 84.77281.84NoNo043
24B:B:G306 B:B:V296 84.63851.84NoYes045
25B:B:L284 B:B:V296 84.5775.96NoYes055
26B:B:L284 G:G:L51 84.44634.15NoYes056
27G:G:D48 G:G:L51 83.46078.14YesYes096
28G:G:D48 G:G:P49 83.08394.83YesNo097
29B:B:M325 G:G:P49 82.71768.39YesNo057
30B:B:M325 G:G:P60 73.44675.03YesNo059
31B:B:Y85 G:G:P60 64.558615.3YesNo1249
32B:B:Q75 B:B:Y59 50.00715.78NoYes298
33B:B:W332 B:B:Y59 49.962515.43YesYes298
34B:B:R314 B:B:W332 51.634126.99YesYes289
35B:B:D290 B:B:R314 48.12814.29YesYes268
36A:A:F238 B:B:W99 50.131815.03YesYes099
37A:A:F238 A:A:W234 49.7754.01YesYes099
38A:A:R231 A:A:W234 94.72744YesYes599
39B:B:L117 B:B:W99 49.89235.69NoYes099
40A:A:W234 B:B:L117 49.77474.56YesNo099
41A:A:C365 A:A:D368 11.85369.34YesNo089
42A:A:D368 A:A:T364 11.81745.78NoYes099
43A:A:D272 A:A:R231 47.507810.72YesYes589
44A:A:I276 A:A:R231 47.26935.01NoYes589
45B:B:F253 B:B:H225 12.63734.53YesYes369
46B:B:F222 B:B:F253 19.574411.79YesYes386
47B:B:F222 B:B:Q220 22.69377.03YesYes387
48B:B:L210 B:B:Q220 42.23253.99YesYes057
49B:B:L198 B:B:L210 21.74384.15NoYes035
50B:B:D212 B:B:L198 22.05635.43YesNo093
51B:B:D212 B:B:E215 47.56383.9YesNo093
52B:B:E215 B:B:M217 47.87286.77NoNo033
53B:B:M217 G:G:M21 48.18175.78NoNo031
54G:G:M21 G:G:Q18 48.490410.88NoNo019
55B:B:C218 G:G:Q18 48.79924.58NoNo059
56B:B:C218 B:B:K209 24.53228.08NoYes756
57B:B:H183 B:B:K209 24.98915.72YesYes796
58B:B:H183 B:B:V187 26.19995.54YesNo099
59B:B:S160 B:B:V187 28.07146.46YesNo069
60B:B:C148 B:B:S160 55.01593.44NoYes066
61B:B:C148 B:B:R150 66.45635.57NoNo066
62B:B:H62 B:B:R150 66.592510.16NoNo066
63B:B:H62 B:B:Y105 66.72884.36NoYes066
64B:B:L210 B:B:R219 21.74384.86YesNo055
65B:B:D212 B:B:R219 22.05637.15YesNo095
66B:B:C218 B:B:W211 24.57563.92NoYes758
67B:B:F199 B:B:W211 24.654418.04YesYes798
68B:B:F199 B:B:L190 26.35276.09YesNo795
69B:B:L190 B:B:S160 26.667.51NoYes056
70A:A:D272 A:A:F246 47.09135.97YesYes589
71A:A:F246 A:A:I276 47.06073.77YesNo598
72A:A:F246 A:A:F273 54.57384.29YesYes599
73A:A:F246 A:A:L289 39.13173.65YesYes599
74A:A:F273 A:A:F345 24.15784.29YesYes598
75A:A:F345 A:A:L289 23.72884.87YesYes589
76A:A:L297 A:A:Y253 11.60528.21NoNo088
77A:A:I308 A:A:Y253 15.955910.88NoNo078
78A:A:F315 A:A:I308 17.40615.07YesNo067
79A:A:F315 A:A:F340 33.348112.86YesYes067
80A:A:E344 A:A:F340 46.384110.49NoYes1957
81A:A:E344 A:A:L270 55.07973.98NoYes056
82A:A:F345 A:A:L270 44.85096.09YesYes086
83A:A:I348 A:A:L270 21.91765.71NoYes046
84A:A:F273 A:A:I348 22.91485.02YesNo094
85A:A:L270 A:A:Q267 10.14636.65YesNo064
86A:A:L289 A:A:P361 13.78563.28YesNo095
87A:A:F363 A:A:R342 11.98115.34NoNo054
88A:A:P361 A:A:R342 13.33185.76NoNo054
89A:A:F363 A:A:K338 13.21112.41NoNo055
90A:A:K338 A:A:Q294 12.81294.07NoNo056
91A:A:F340 A:A:Y318 11.60075.16YesNo076
92A:A:Y391 R:R:R123 11.97566.17YesYes449
93R:R:R123 R:R:Y276 11.97864.12YesYes499
94B:B:D258 B:B:Q220 16.39218.27YesYes377
95B:B:D258 B:B:R22 13.91234.76YesYes076
96B:B:I18 B:B:R22 10.75385.01NoYes076
97B:B:I18 G:G:A23 10.12181.62NoNo078
98B:B:W297 B:B:Y264 14.721711.58YesYes085
99B:B:C148 B:B:T102 13.56613.38NoNo068
100B:B:C149 B:B:T102 13.40188.45YesNo088
101B:B:W297 B:B:Y289 12.43167.72YesYes287
102R:R:L116 R:R:Y276 10.54394.69YesYes499
103A:A:C365 A:A:Q294 12.41844.58YesNo086
104B:B:C271 B:B:Y289 14.69014.03NoYes257
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:R103 5.82 6 Yes Yes 0 4 0 1
L:L:?1 R:R:Y106 18.71 6 Yes No 0 3 0 1
L:L:?1 R:R:C164 5.06 6 Yes Yes 0 6 0 1
L:L:?1 R:R:C175 6.33 6 Yes No 0 8 0 1
L:L:?1 R:R:D179 27.07 6 Yes Yes 0 3 0 1
L:L:?1 R:R:Q182 4.25 6 Yes No 0 6 0 1
L:L:?1 R:R:A183 6.29 6 Yes No 0 5 0 1
L:L:?1 R:R:S238 4.79 6 Yes No 0 7 0 1
L:L:?1 R:R:W241 22.72 6 Yes No 0 4 0 1
L:L:?1 R:R:F242 4.86 6 Yes No 0 5 0 1
L:L:?1 R:R:Y245 5.61 6 Yes Yes 0 4 0 1
R:R:E99 R:R:R103 9.3 6 No Yes 5 4 2 1
R:R:E99 R:R:S165 8.62 6 No No 5 3 2 2
R:R:K102 R:R:R103 7.43 0 No Yes 3 4 2 1
R:R:K102 R:R:Y106 9.55 0 No No 3 3 2 1
R:R:R103 R:R:S161 5.27 6 Yes No 4 3 1 2
R:R:R103 R:R:S165 5.27 6 Yes No 4 3 1 2
R:R:W241 R:R:Y106 7.72 6 No No 4 3 1 1
R:R:S238 R:R:Y109 7.63 0 No Yes 7 8 1 2
R:R:M156 R:R:Q182 12.23 0 No No 4 6 2 1
R:R:N157 R:R:Q182 10.56 14 Yes No 7 6 2 1
R:R:C164 R:R:T160 3.38 6 Yes No 6 4 1 2
R:R:C164 R:R:C175 7.28 6 Yes No 6 8 1 1
R:R:C164 R:R:D179 4.67 6 Yes Yes 6 3 1 1
R:R:C175 R:R:D179 4.67 6 No Yes 8 3 1 1
R:R:F176 R:R:M180 13.68 6 No No 2 3 2 2
R:R:F176 R:R:Y245 10.32 6 No Yes 2 4 2 1
R:R:F176 R:R:W246 5.01 6 No No 2 4 2 2
R:R:D179 R:R:Y245 6.9 6 Yes Yes 3 4 1 1
R:R:M180 R:R:Y245 3.59 6 No Yes 3 4 2 1
R:R:M180 R:R:W246 4.65 6 No No 3 4 2 2
R:R:F242 R:R:M187 4.98 0 No No 5 7 1 2
R:R:W246 R:R:Y245 5.79 6 No Yes 4 4 2 1
R:R:I186 R:R:S238 3.1 0 No No 7 7 2 1
L:L:?1 R:R:F170 2.92 6 Yes No 0 1 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
71.43Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
46.15Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
28.57Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
26.67Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
26.32Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
26.32Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
25.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
25.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
25.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
25.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
23.81Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
23.81Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
23.81Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
23.81Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
23.81Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
23.81Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
23.53Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.53Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
23.53Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.73Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
22.73Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
22.22Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
22.22Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
22.22Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
22.22Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
22.22Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
21.74Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
21.05Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
21.05Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
21.05Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
21.05Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
21.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.05Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
21.05Single9CHXS-Carazolol9CHX-β2-S-Carazolol
21.05Single9IYAONO-97105319IYA-GPR55-ONO-9710531
21.05Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
21.05Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
20.83Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
20.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
20.00Single6HLPNetupitant6HLP-NK1-Netupitant
20.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
20.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
20.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
20.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
19.05Single2YDVNECA2YDV-A2A-NECA
19.05Single4UHRCGS216804UHR-A2A-CGS21680
19.05Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
19.05Single5G53NECA5G53-A2A-NECA-Gs
19.05Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
19.05Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
19.05Single6J21Aprepitant6J21-NK1-Aprepitant
19.05Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
19.05Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
19.05Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
19.05Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
19.05Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
19.05Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
19.05Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
19.05Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
19.05Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
19.05Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
19.05Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
19.05Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.05Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
19.05Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
18.75Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.75Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
18.75Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
18.52Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
18.18Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
18.18Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
18.18Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.18Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.18Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8JWY2-1188JWY-A2A-2-118
18.18Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
18.18Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
17.65Single3PBLEticlopride3PBL-D3-Eticlopride
17.65Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
17.65Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
17.65Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.65Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.65Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
17.65Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
17.65Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
17.65Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
17.65Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
17.65Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
17.65Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
17.65Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
17.65Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.65Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
17.65Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
17.65Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
17.39Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
17.39Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
17.39Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
17.39Single7EZCUKA7EZC-A2A-UKA
17.39Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
17.39Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
17.39Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
17.39Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
17.39Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
16.67Single3NY9ICI118-5513NY9-β2-ICI118-551
16.67Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
16.67Single4UG2CGS216804UG2-A2A-CGS21680
16.67Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
16.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.67Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
16.67Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
16.67Single6ME2Ramelteon6ME2-MT1-Ramelteon
16.67Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
16.67Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
16.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
16.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
16.67Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
16.67Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
16.67Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
16.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
16.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
16.67Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
16.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
16.67Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
16.67Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
16.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
16.67Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Consensusalpha2_offOrthosteric Ligandalpha2c_off
16.67Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
16.67Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
16.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.00Single8WDTphotoNECA8WDT-A2A-photoNECA
16.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
16.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
16.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
16.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
16.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
16.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.79Single3RZECidoxepin3RZE-H1-Cidoxepin
15.79Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
15.79Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
15.79Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.79Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.79Single5JTBZM-2413855JTB-A2A-ZM-241385
15.79Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.79Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
15.79Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
15.79Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
15.79Single5UVIZM-2413855UVI-A2A-ZM-241385
15.79Single6AQFZM-2413856AQF-A2A-ZM-241385
15.79Single6IQLL7458706IQL-D4-L745870
15.79Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
15.79Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
15.79Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
15.79Single6PS0S-Carazolol6PS0-β2-S-Carazolol
15.79Single6PS4ICI118-5516PS4-β2-ICI118-551
15.79Single6PS5S-Propranolol6PS5-β2-S-Propranolol
15.79Single6TPNHTL66416TPN-OX2-HTL6641
15.79Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.79Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
15.79Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
15.79Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
15.79Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
15.79Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
15.79Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single7T32ZM-2413857T32-A2A-ZM-241385
15.79Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
15.79Single7VV6C48/807VV6-MRGPRX2-C48/80
15.79Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
15.79Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
15.79Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
15.79Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
15.79Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
15.79Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
15.79Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
15.79Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
15.79Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
15.79Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
15.79Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
15.79Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
15.79Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.79Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.79Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
15.79Single9BJKNaloxone9BJK-μ-Naloxone-NAM
15.79Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
15.79Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
15.79Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
15.79Consensusa2_offOrthosteric Liganda2a_off
15.79Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
15.79Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
15.79Consensusalpha1_onOrthosteric Ligandalpha1a_on
15.79Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
15.79Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
15.79Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
15.79Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
15.79Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
15.79Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.79Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
15.79Consensusopsins_offOrthosteric Ligandrhodopsin_off
15.79Consensussensory_offOrthosteric Ligandopsins_off
15.38Single3QAKUK-4320973QAK-A2A-UK-432097
15.38Single6HLOAprepitant6HLO-NK1-Aprepitant
15.38Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
15.38Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
15.38Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
15.38Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
15.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
15.00Single2Y02Carmoterol2Y02-β1-Carmoterol
15.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
15.00Single3EMLZM-2413853EML-A2A-ZM-241385
15.00Single3NY8ICI118-5513NY8-β2-ICI118-551
15.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
15.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
15.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
15.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
15.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
15.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
15.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
15.00Single5DHGC-355DHG-NOP-C-35
15.00Single5DHHSB-6121115DHH-NOP-SB-612111
15.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
15.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
15.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
15.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
15.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
15.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
15.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
15.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
15.00Single6PS1Timolol6PS1-β2-Timolol
15.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
15.00Single6S0LZM-2413856S0L-A2A-ZM-241385
15.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
15.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
15.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
15.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.00Single7PYRPSB-21157PYR-A2A-PSB-2115
15.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
15.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
15.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
15.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
15.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
15.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
15.00Single8CU6LJ-45178CU6-A2A-LJ-4517
15.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
15.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
15.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
15.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
15.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
15.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
15.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
15.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
15.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
15.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
15.00Single8JJOAlprenolol8JJO-β2-Alprenolol
15.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
15.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
15.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
15.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
15.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
15.00Single8X63Mepyramine8X63-H1-Mepyramine
15.00Single8X64Desloratadine8X64-H1-Desloratadine
15.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
15.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
15.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
15.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
15.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
15.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
15.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.00Consensusa3_onOrthosteric Liganda3a_on
15.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
15.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
15.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
15.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
15.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
15.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
15.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
15.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
15.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.00Consensushistamine_offOrthosteric Ligandh1_off
15.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
15.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
15.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
14.81Single5WF5UK-4320975WF5-A2A-UK-432097
14.81Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.81Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
14.81Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
14.81Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
14.81Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
14.81Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
14.81Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
14.29Single2RH1S-Carazolol2RH1-β2-S-Carazolol
14.29Single2YCWS-Carazolol2YCW-β1-S-Carazolol
14.29Single4NTJAZD12834NTJ-P2Y12-AZD1283
14.29Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
14.29Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
14.29Single5C1MBU725C1M-μ-BU72
14.29Single5D6LS-Carazolol5D6L-β2-S-Carazolol
14.29Single5IUAQ274563485IUA-A2A-Q27456348-Na
14.29Single5JQHS-Carazolol5JQH-β2-S-Carazolol
14.29Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
14.29Single5TVNLSD5TVN-5-HT2B-LSD
14.29Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
14.29Single5XPRBosentan5XPR-ETB-Bosentan
14.29Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
14.29Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
14.29Single6E67BI1671076E67-β2-BI167107-Gs (fused)
14.29Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
14.29Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
14.29Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
14.29Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
14.29Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
14.29Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
14.29Single6PS6Timolol6PS6-β2-Timolol
14.29Single6S0QZM-2413856S0Q-A2A-ZM-241385
14.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
14.29Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
14.29Single7C61Ergotamine7C61-5-HT1B-Ergotamine
14.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
14.29Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
14.29Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
14.29Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.29Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
14.29Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
14.29Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
14.29Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
14.29Single7W41PD1762527W41-BB2-PD176252
14.29Single7WC6LSD7WC6-5-HT2A-LSD
14.29Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
14.29Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
14.29Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
14.29Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
14.29Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
14.29Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GNEKW-63568GNE-A2A-KW-6356-Na
14.29Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
14.29Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
14.29Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
14.29Single8JXSPF-61428JXS-D1-PF-6142
14.29Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
14.29Single8S4DCMF-0198S4D-Apelin-CMF-019
14.29Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
14.29Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
14.29Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
14.29Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
14.29Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.29Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.29Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.29Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
14.29Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
14.29Consensusa3_on_gpOrthosteric Liganda3a_on_gp
14.29Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Consensusadenosine_offOrthosteric Liganda1_off a2_off
14.29Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
14.29Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
14.29Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
14.29Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
14.29Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
14.29Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
14.29Consensusamine_offonOrthosteric Ligandamine_off amine_on
14.29Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
14.29Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
14.29Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
14.29Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
14.29Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
14.29Consensusbombesin_offOrthosteric Ligandbb2_off
14.29Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
14.29Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
14.29Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
14.29Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
14.29Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensustrace-amine_onOrthosteric Ligandta1_on
13.79Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
13.79Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.79Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
13.79Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
13.64Single3P0GBI1671073P0G-β2-BI167107
13.64Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
13.64Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
13.64Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
13.64Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
13.64Single5D5AS-Carazolol5D5A-β2-S-Carazolol
13.64Single5D5BS-Carazolol5D5B-β2-S-Carazolol
13.64Single5TZRMK86665TZR-FFA1-MK8666
13.64Single5XRAAM115425XRA-CB1-AM11542
13.64Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.64Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
13.64Single6E59L-7607356E59-NK1-L-760735
13.64Single6H7JIsoprenaline6H7J-β1-Isoprenaline
13.64Single6J20Aprepitant6J20-NK1-Aprepitant
13.64Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
13.64Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
13.64Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
13.64Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
13.64Single6TQ7SB-3348676TQ7-OX1-SB-334867
13.64Single6WGTLSD6WGT-5-HT2A-LSD
13.64Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
13.64Single7FEECP559407FEE-CB1-CP55940-ZCZ011
13.64Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
13.64Single7PX4PSB-21137PX4-A2A-PSB-2113
13.64Single7R0CAVP7R0C-V2-AVP-Arrestin2
13.64Single7TUYGSK682753A7TUY-GPR183-GSK682753A
13.64Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
13.64Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
13.64Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
13.64Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
13.64Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
13.64Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
13.64Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
13.64Single8E0GBU728E0G-μ-BU72
13.64Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
13.64Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.64Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
13.64Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
13.64Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
13.64Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
13.64Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
13.64Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
13.64Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
13.64Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
13.64Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
13.64Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
13.64Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
13.64Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
13.64Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.64Single8XVLZibotentan8XVL-ETA-Zibotentan
13.64Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
13.64Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
13.64Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
13.64Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusa2_onOrthosteric Liganda2b_on
13.64Consensusa2_on_gpOrthosteric Liganda2b_on_gp
13.64Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.64Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.64Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
13.64Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
13.64Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
13.64Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
13.64Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
13.64Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
13.64Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
13.64Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.64Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
13.64Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
13.64Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
13.64Consensuslpa_onOrthosteric Ligandlpa1_on
13.64Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
13.64Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
13.64Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Consensustachykinin_offOrthosteric Ligandnk1_off
13.64Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
13.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.33Single8PWNTheophylline8PWN-A2A-Theophylline
13.33Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
13.33Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.33Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.33Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
13.04Single3D4STimolol3D4S-β2-Timolol
13.04Single4AMIBucindolol4AMI-β1-Bucindolol
13.04Single4LDEBI1671074LDE-β2-BI167107
13.04Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.04Single4RWADIPP-NH24RWA-δ-DIPP-NH2
13.04Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
13.04Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
13.04Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
13.04Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
13.04Single6KQICP559406KQI-CB1-CP55940-Org27569
13.04Single6MXTSalmeterol6MXT-β2-Salmeterol
13.04Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
13.04Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
13.04Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
13.04Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
13.04Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
13.04Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
13.04Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
13.04Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
13.04Single7YITNalfurafine7YIT-κ-Nalfurafine
13.04Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
13.04Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
13.04Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
13.04Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
13.04Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
13.04Single8JJ8Formoterol8JJ8-β2-Formoterol
13.04Single8JJLOlodaterol8JJL-β2-Olodaterol
13.04Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
13.04Single8JWZAB9288JWZ-A2A-AB928-Na
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.04Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
13.04Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
13.04Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
13.04Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
13.04Consensusalpha1_offOrthosteric Ligandalpha1a_off
13.04Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
13.04Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
13.04Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
13.04Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
13.04Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
13.04Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.04Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
13.04Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
13.04Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.04Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
13.04Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
13.04Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
13.04Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
13.04Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
13.04Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
13.04Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
13.04Consensuslpa_offOrthosteric Ligandlpa1_off
13.04Consensuslpl_offOrthosteric Ligands1p_off lpa_off
13.04Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
13.04Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
13.04Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
13.04Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.04Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.04Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
13.04Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.90Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
12.90Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.90Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.90Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.90Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.90Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.90Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
12.90Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.90Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.50Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
12.50Single5X93K-87945X93-ETB-K-8794
12.50Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
12.50Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
12.50Single6H7LDobutamine6H7L-β1-Dobutamine
12.50Single6IBLArformoterol6IBL-β1-Arformoterol
12.50Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
12.50Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.50Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
12.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.50Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
12.50Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
12.50Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.50Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
12.50Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
12.50Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.50Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.50Single7UM4AS26747237UM4-5-HT5A-AS2674723
12.50Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
12.50Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
12.50Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
12.50Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single8A2OTheophylline8A2O-A2A-Theophylline-Na
12.50Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
12.50Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
12.50Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
12.50Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
12.50Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
12.50Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.50Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
12.50Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
12.50Single9CHUNoradrenaline9CHU-β2-Noradrenaline
12.50Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
12.50Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.50Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.50Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
12.50Consensuscck_onOrthosteric Ligandccka_on cckb_on
12.50Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
12.50Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.50Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.50Consensusendothelin_offOrthosteric Ligandetb_off
12.50Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
12.50Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
12.50Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
12.50Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.50Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.50Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.50Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
12.12Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.12Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
12.12Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
12.12Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
12.12Consensusbombesin_onOrthosteric Ligandbb2_on
12.12Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
12.12Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
12.12Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
12.00Single5WF6UK-4320975WF6-A2A-UK-432097
12.00Single5ZTYAM102575ZTY-CB2-AM10257
12.00Single6PT3DPI-2876PT3-δ-DPI-287
12.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
12.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
12.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
12.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
12.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
12.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
12.00Single8X5YAstemizole8X5Y-H1-Astemizole
12.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
12.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
12.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
11.76Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
11.76Single3UZAGTPL92363UZA-A2A-GTPL9236
11.76Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.76Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.76Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.76Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
11.76Single7WC5Psilocin7WC5-5-HT2A-Psilocin
11.76Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
11.76Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
11.76Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
11.76Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
11.76Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.76Consensus5ht2_onOrthosteric Ligand5ht2b_on
11.76Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.76Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
11.76Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
11.76Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.76Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
11.76Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
11.54Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
11.54Single4IARErgotamine4IAR-5-HT1B-Ergotamine
11.54Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
11.54Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.54Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
11.54Single7F8XNN90567F8X-CCKA-NN9056
11.54Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
11.54Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
11.54Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
11.54Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.54Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
11.54Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
11.54Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
11.54Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
11.54Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
11.54Single8IEBA1LYA8IEB-GPR156-A1LYA
11.54Single8WKYPG-9348WKY-MC4-PG-934
11.54Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
11.54Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.54Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
11.54Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
11.54Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.54Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.54Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
11.54Consensuslpl_onOrthosteric Ligands1p_on lpa_on
11.54Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
11.54Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
11.43Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.43Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.43Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
11.11Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.11Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
11.11Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.11Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
11.11Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.11Single6HLLCP999946HLL-NK1-CP99994
11.11Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.11Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.11Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
11.11Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
11.11Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.11Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
11.11Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
11.11Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.11Single7SRQLSD7SRQ-5-HT2B-LSD
11.11Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.11Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
11.11Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.11Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
11.11Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
11.11Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
11.11Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
11.11Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
11.11Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
11.11Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
11.11Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
11.11Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.11Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
11.11Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
11.11Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
11.11Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
11.11Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
10.81Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71Single6PT2KGCHM076PT2-δ-KGCHM07
10.71Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
10.71Single6W25SHU91196W25-MC4-SHU9119-Ca
10.71Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
10.71Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
10.71Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
10.71Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
10.71Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
10.71Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.71Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
10.71Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.71Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
10.71Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
10.71Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
10.53Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.53Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
10.53Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
10.53Single3PWHZM-2413853PWH-A2A-ZM-241385
10.53Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.53Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.53Single6AKXA4R6AKX-CCR5-A4R
10.53Single6B73MP11046B73-κ-MP1104
10.53Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.53Single6DS0Ly2660976DS0-5-HT2B-Ly266097
10.53Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.53Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.53Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.53Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
10.53Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
10.53Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
10.53Single7F8ULintitript7F8U-CCKA-Lintitript
10.53Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
10.53Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.53Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.53Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
10.53Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
10.53Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
10.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
10.53Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
10.53Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
10.53Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.53Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
10.53Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
10.53Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
10.53Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
10.53Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
10.53Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
10.53Single8GNGIstradefylline8GNG-A2A-Istradefylline
10.53Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
10.53Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
10.53Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
10.53Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
10.53Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
10.53Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
10.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
10.53Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.53Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.53Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.53Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
10.53Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
10.53Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
10.53Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.53Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.53Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.53Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.53Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.34Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.34Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
10.34Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.34Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.34Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
10.34Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
10.34Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
10.34Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
10.34Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.34Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.34Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.34Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
10.34Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
10.34Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.34Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
10.34Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
10.34Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.34Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.34Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.34Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
10.34Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
10.34Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
10.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
10.00Single2YDOAdenosine2YDO-A2A-Adenosine
10.00Single3REYXAC3REY-A2A-XAC
10.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
10.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
10.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
10.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
10.00Single6A94Zotepine6A94-5-HT2A-Zotepine
10.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
10.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.00Single6KUXRS-799486KUX-α2a-RS-79948
10.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
10.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
10.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
10.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
10.00Single6TPGEMPA6TPG-OX2-EMPA
10.00Single6VI4JDTic6VI4-κ-JDTic
10.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
10.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
10.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.00Single7AROLUF58337ARO-A2A-LUF5833-Na
10.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
10.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
10.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
10.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
10.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
10.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
10.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
10.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
10.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
10.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
10.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
10.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
10.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
10.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
10.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
10.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
10.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
10.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
10.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
10.00Single8IYXYL-3658IYX-GPR34-YL-365
10.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
10.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
10.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
10.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
10.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
10.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
10.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
10.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
10.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
10.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
10.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
10.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
10.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
10.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
10.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
10.00Single8ZRTET-18ZRT-ETB-ET-1
10.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
10.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
10.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
10.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
10.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.68Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
9.68Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
9.68Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
9.68Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
9.68Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
9.68Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
9.68Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
9.68Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
9.68Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
9.68Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.68Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
9.68Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
9.68Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
9.68Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.68Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
9.68Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
9.52Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
9.52Single2Y01Dobutamine2Y01-β1-Dobutamine
9.52Single2Y04Salbutamol2Y04-β1-Salbutamol
9.52Single4DAJTiotropium4DAJ-M3-Tiotropium
9.52Single4EJ4Naltrindole4EJ4-δ-Naltrindole
9.52Single4MQSIperoxo4MQS-M2-Iperoxo
9.52Single4QIMANTA XV4QIM-SMO-ANTA XV
9.52Single4U14Tiotropium4U14-M3-Tiotropium
9.52Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
9.52Single5DSGTiotropium5DSG-M4-Tiotropium
9.52Single5UENDU1725UEN-A1-DU172
9.52Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
9.52Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
9.52Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
9.52Single6DRXLisuride6DRX-5-HT2B-Lisuride
9.52Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
9.52Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
9.52Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
9.52Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
9.52Single6H7MSalbutamol6H7M-β1-Salbutamol
9.52Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
9.52Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.52Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.52Single7BU7BI1671077BU7-β1-BI167107
9.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.52Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.52Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.52Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
9.52Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
9.52Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.52Single7V3ZCP559407V3Z-CB1-CP55940
9.52Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
9.52Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.52Single7WC7Lisuride7WC7-5-HT2A-Lisuride
9.52Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
9.52Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
9.52Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
9.52Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
9.52Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
9.52Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
9.52Single8JXRLSD8JXR-D1-LSD
9.52Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
9.52Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
9.52Single8RLNLUF58348RLN-A2A-LUF5834
9.52Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
9.52Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
9.52Single8T1WCVN4248T1W-GPR6-CVN424
9.52Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
9.52Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
9.52Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
9.52Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
9.52Consensuscck_offOrthosteric Ligandccka_off
9.52Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
9.52Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.52Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
9.52Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
9.52Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
9.52Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.52Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.38Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
9.38Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
9.38Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
9.38Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
9.38Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
9.38Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
9.38Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
9.38Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
9.38Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
9.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
9.38Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
9.38Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
9.38Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.38Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
9.38Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
9.09Single2Y00Dobutamine2Y00-β1-Dobutamine
9.09Single2Y03Isoprenaline2Y03-β1-Isoprenaline
9.09Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
9.09Single5N2RPSB-365N2R-A2A-PSB-36-Na
9.09Single5N2SPSB365N2S-A1-PSB36
9.09Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
9.09Single5WIUNemonapride5WIU-D4-Nemonapride
9.09Single5WIVNemonapride5WIV-D4-Nemonapride-Na
9.09Single5WQCEMPA5WQC-OX2-EMPA
9.09Single6D26Fevipiprant6D26-DP2-Fevipiprant
9.09Single6IGLIRL16206IGL-ETB-IRL1620
9.09Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
9.09Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.09Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
9.09Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
9.09Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
9.09Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
9.09Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
9.09Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
9.09Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
9.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.09Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
9.09Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
9.09Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
9.09Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
9.09Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.09Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.09Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
9.09Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
9.09Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
9.09Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.09Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.09Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.09Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
9.09Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
9.09Single8IY6Endothelin-18IY6-ETB-Endothelin-1
9.09Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
9.09Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
9.09Single8TF5Oleic acid8TF5-GPR6-Oleic acid
9.09Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
9.09Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
9.09Single8ZMFA1L108ZMF-5-HT2C-A1L10
9.09Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
9.09Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
9.09Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
9.09Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
9.09Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.09Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.09Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
9.09Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
9.09Consensusdp_offOrthosteric Liganddp2_off
9.09Consensusendothelin_onOrthosteric Ligandetb_on eta_on
9.09Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
9.09Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
9.09Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
9.09Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
9.09Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
8.82Single5GLHEndothelin-15GLH-ETB-Endothelin-1
8.82Single6IGKEndothelin-36IGK-ETB-Endothelin-3
8.82Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
8.82Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
8.82Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
8.82Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
8.82Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
8.82Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
8.82Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
8.70Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.70Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.70Single4DJHJDTic4DJH-κ-JDTic
8.70Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
8.70Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
8.70Single4U15Tiotropium4U15-M3-Tiotropium
8.70Single5V54Methiothepin5V54-5-HT1B-Methiothepin
8.70Single5V56TC1145V56-SMO-TC114
8.70Single5XR8AM8415XR8-CB1-AM841
8.70Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
8.70Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
8.70Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
8.70Single6OL9Tiotropium6OL9-M5-Tiotropium
8.70Single6OS1TRV0266OS1-AT1-TRV026
8.70Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.70Single7B6WCyclazosin7B6W-α1b-Cyclazosin
8.70Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
8.70Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
8.70Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
8.70Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.70Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
8.70Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
8.70Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
8.70Single7P2L4YI7P2L-mGlu5-4YI
8.70Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
8.70Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
8.70Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
8.70Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.70Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
8.70Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
8.70Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
8.70Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
8.70Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
8.70Single8EA0Iperoxo8EA0-M3-Iperoxo
8.70Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
8.70Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
8.70Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
8.70Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
8.70Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
8.70Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
8.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.70Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
8.70Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
8.70Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
8.70Consensus5ht1_offOrthosteric Ligand5ht1b_off
8.70Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
8.70Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
8.70Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
8.70Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
8.70Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.70Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
8.70Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
8.70Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
8.70Consensusneurotensin_onOrthosteric Ligandnts1_on
8.70Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.57Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
8.57Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
8.57Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.57Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
8.57Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
8.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.57Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
8.33Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
8.33Single4N4WSANT-14N4W-SMO-SANT-1
8.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.33Single4XESNeurotensin4XES-NTS1-Neurotensin
8.33Single5CXVTiotropium5CXV-M1-Tiotropium
8.33Single6A93Risperidone6A93-5-HT2A-Risperidone
8.33Single6CM4Risperidone6CM4-D2-Risperidone
8.33Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
8.33Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
8.33Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
8.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
8.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
8.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
8.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
8.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.33Single7DFPSpiperone7DFP-D2-Spiperone
8.33Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
8.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
8.33Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
8.33Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
8.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
8.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
8.33Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
8.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
8.33Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
8.33Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.33Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.33Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
8.33Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8XQJJN2418XQJ-Apelin-JN241
8.33Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
8.33Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
8.33Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
8.33Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
8.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
8.33Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
8.33Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
8.33Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
8.33Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
8.33Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
8.33Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.33Consensusorexin_onOrthosteric Ligandox2_on
8.11Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
8.11Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.11Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
8.11Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
8.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.11Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
8.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
8.00Single6K1QIRL25006K1Q-ETB-IRL2500
8.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
8.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
8.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
8.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
8.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
8.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
8.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
8.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
8.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
8.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
8.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
8.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
8.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
8.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
8.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.00Single8XVJMacitentan8XVJ-ETA-Macitentan
8.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
8.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
8.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
8.00Consensuschemerin_onOrthosteric Ligandcml1_on
8.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
8.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
8.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
8.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
8.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
7.69Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
7.69Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
7.69Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
7.69Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
7.69Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
7.69Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
7.69Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
7.69Single7SK9CCX6627SK9-ACKR3-CCX662
7.69Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
7.69Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
7.69Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
7.69Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
7.69Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
7.69Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
7.69Single8IEIA1LYA8IEI-GPR156-A1LYA
7.69Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8XQJJN2418XQJ-Apelin-JN241
7.69Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.69Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
7.69Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
7.69Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
7.69Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
7.69Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
7.41Single4XT1Fractalkine4XT1-US28-Fractalkine
7.41Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
7.41Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
7.41Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
7.41Single7QA8Peptide7QA8-STE2-Peptide
7.41Single7QA8Peptide7QA8-STE2-Peptide
7.41Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
7.41Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
7.41Single8IEIA1LYA8IEI-GPR156-A1LYA
7.41Single8IEPA1LYA8IEP-GPR156-A1LYA
7.41Single8IEPA1LYA8IEP-GPR156-A1LYA
7.41Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
7.41Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
7.41Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
7.41Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
7.41Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
7.41Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
7.41Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
7.41Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
7.41Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
7.41Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
7.41Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.14Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
7.14Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8IEBA1LYA8IEB-GPR156-A1LYA
7.14Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
7.14Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.14Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
7.14Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
7.14Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
7.14Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
7.14Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
7.14Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
7.14Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
7.14Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
7.14Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
7.14Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
6.90Single3OE0CVX153OE0-CXCR4-CVX15
6.90Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
6.90Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
6.90Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
6.90Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
6.90Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
6.90Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.90Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
6.90Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.90Consensusangiotensin_onOrthosteric Ligandat1_on
6.90Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
6.90Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
6.90Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
6.90Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
6.90Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
6.90Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
6.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
6.67Single6JODAngiotensin II6JOD-AT2-Angiotensin II
6.67Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
6.67Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
6.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.67Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
6.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
6.67Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
6.67Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
6.67Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
6.67Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
6.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
6.67Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
6.67Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
6.67Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.67Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.67Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
6.67Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
6.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
6.67Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
6.67Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
6.67Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
6.67Consensusvasop-oxy_onOrthosteric Ligandv2_on
6.67Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
6.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.45Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
6.45Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
6.45Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.45Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
6.45Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
6.45Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
6.45Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
6.45Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
6.45Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
6.45Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
6.45Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.45Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.25Single4XT3Fractalkine4XT3-US28-Fractalkine
6.25Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
6.25Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.25Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.25Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
6.25Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
6.25Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.25Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.25Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
6.25Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
6.25Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
6.25Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
6.06Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.06Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
6.06Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
6.06Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
6.06Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
6.06Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.06Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
6.06Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
5.88Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
5.88Single3RFMCaffeine3RFM-A2A-Caffeine
5.88Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.88Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
5.88Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
5.88Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.88Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
5.88Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
5.88Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
5.88Consensusbradykinin_onOrthosteric Ligandbk2_on
5.88Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
5.88Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off
5.71Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
5.56Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.56Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.56Single3OE6IT1t3OE6-CXCR4-IT1t
5.56Single4XNWMRS25004XNW-P2Y1-MRS2500
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
5.56Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
5.56Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.56Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.56Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
5.56Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
5.56Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
5.56Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.56Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.56Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
5.56Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
5.56Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.56Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.56Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
5.56Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
5.56Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.56Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.56Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.26Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
5.26Single3OE9IT1t3OE9-CXCR4-IT1t
5.26Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.26Single5L7IVismodegib5L7I-SMO-Vismodegib
5.26Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.26Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.26Single6LI0C176LI0-GPR52-C17
5.26Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.26Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
5.26Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
5.26Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.26Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
5.26Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
5.26Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
5.26Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
5.26Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
5.26Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
5.26Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
5.26Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.26Single8K5BNiacin8K5B-HCA2-Niacin
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.26Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.26Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.26Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.26Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
5.26Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.26Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
5.26Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
5.26Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
5.26Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
5.26Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
5.26Single9B9Y7DY9B9Y-CB1-7DY
5.26Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
5.26Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.26Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.26Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
5.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
5.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
5.00Single3ODUIT1t3ODU-CXCR4-IT1t
5.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
5.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
5.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.00Single4QINSAG1.54QIN-SMO-SAG1.5
5.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
5.00Single5U09Taranabant5U09-CB1-Taranabant
5.00Single5WS3EMPA5WS3-OX2-EMPA
5.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
5.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
5.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
5.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00Single6TODEMPA6TOD-OX1-EMPA-Na
5.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
5.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
5.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
5.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.00Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
5.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
5.00Single7XRRLemborexant7XRR-OX2-Lemborexant
5.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
5.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
5.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
5.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
5.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
5.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
5.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
5.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
5.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
5.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
5.00Single8IWESpermidine8IWE-TA9-Spermidine
5.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
5.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
5.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
5.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
5.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
5.00Single9BA0A1AKN9BA0-CB1-A1AKN
5.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.00Consensusangiotensin_offOrthosteric Ligandat1_off
5.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
5.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
5.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
5.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
5.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
5.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
5.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
5.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
5.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
4.76Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
4.76Single4ZJCSB-6740424ZJC-OX1-SB-674042
4.76Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.76Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
4.76Single6TP3Nemorexant6TP3-OX1-Nemorexant
4.76Single6TPKRetosiban6TPK-OT-Retosiban
4.76Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
4.76Single6V9SGTPL114036V9S-OX1-GTPL11403
4.76Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.76Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
4.76Single6ZINSR486926ZIN-NTS1-SR48692
4.76Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
4.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.76Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
4.76Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
4.76Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
4.76Single7UL3Famotidine7UL3-H2-Famotidine
4.76Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.76Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
4.76Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
4.76Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.76Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
4.76Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.76Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.76Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
4.76Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8IHKAcifran8IHK-HCA3-Acifran
4.76Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.76Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
4.76Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
4.76Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
4.76Single8K5CAcipimox8K5C-HCA2-Acipimox
4.76Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
4.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
4.76Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
4.76Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
4.76Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
4.76Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.76Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
4.76Consensusgrh_offOrthosteric Ligandgnrh1_off
4.76Consensushca_onOrthosteric Ligandhca2_on
4.76Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
4.76Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.76Consensusvasop-oxy_offOrthosteric Ligandot_off
4.65Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
4.55Single4QKX35V4QKX-β2-35V
4.55Single4YAYZD-71554YAY-AT1-ZD-7155
4.55Single5T04Neurotensin5T04-NTS1-Neurotensin
4.55Single5TGZAM65385TGZ-CB1-AM6538
4.55Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
4.55Single6GPSMK08126GPS-CCR2-MK0812
4.55Single6IIVDaltroban6IIV-TP-Daltroban
4.55Single6TOTLemborexant6TOT-OX1-Lemborexant
4.55Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
4.55Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.55Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
4.55Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.55Single7UL4Alvimopan7UL4-μ-Alvimopan
4.55Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
4.55Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
4.55Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
4.55Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
4.55Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
4.55Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
4.55Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.55Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
4.55Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
4.55Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
4.55Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.55Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
4.55Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
4.55Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
4.55Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
4.55Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9B9ZA1AKO9B9Z-CB1-A1AKO
4.55Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.55Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.55Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.55Consensusblt_onOrthosteric Ligandblt1_on
4.55Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
4.55Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
4.55Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.55Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.55Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
4.55Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
4.55Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
4.55Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
4.55Consensushca_on_gpOrthosteric Ligandhca2_on_gp
4.55Consensusleukotriene_onOrthosteric Ligandblt_on
4.55Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
4.55Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
4.55Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
4.35Single4JKVTaladegib4JKV-SMO-Taladegib
4.35Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
4.35Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
4.35Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
4.35Single6GPXMK08126GPX-CCR2-MK0812
4.35Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Single6LUQHaloperidol6LUQ-D2-Haloperidol
4.35Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.35Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
4.35Single6TP6Filorexant6TP6-OX1-Filorexant
4.35Single6Z4SSR486926Z4S-NTS1-SR48692
4.35Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
4.35Single7C4SS1P7C4S-S1P3-S1P
4.35Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7SINNPS-21437SIN-CaS-NPS-2143
4.35Single7SINNPS-21437SIN-CaS-NPS-2143
4.35Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
4.35Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
4.35Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
4.35Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
4.35Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
4.35Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
4.35Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.35Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
4.35Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
4.35Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
4.35Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
4.35Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
4.35Consensusep_offOrthosteric Ligandep4_off
4.35Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
4.35Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.35Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.35Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.35Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.35Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
4.17Single5V57TC1145V57-SMO-TC114
4.17Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.17Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
4.17Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
4.17Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.17Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
4.17Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
4.17Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
4.17Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
4.17Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
4.17Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.17Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
4.17Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
4.17Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.17Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
4.17Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
4.17Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
4.17Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
4.17Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
4.17Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.17Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.17Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.17Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
4.17Consensusrelaxin_onOrthosteric Ligandrxfp4_on
4.17Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
4.17Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
4.17Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
4.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
4.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
4.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
4.00Single6IIURamatroban6IIU-TP-Ramatroban
4.00Single6OS2TRV0266OS2-AT1-TRV026
4.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
4.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
4.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
4.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
4.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
4.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
4.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
4.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
4.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
4.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.00Single8XWACXCL18XWA-CXCR2-CXCL1
4.00Single8XWMCXCL68XWM-CXCR2-CXCL6
4.00Single8XWSCXCL58XWS-CXCR2-CXCL5
4.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
4.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
4.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
4.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
4.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
4.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
4.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
3.85Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
3.85Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.85Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
3.85Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
3.85Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
3.85Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
3.85Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
3.85Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.85Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
3.85Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
3.85Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
3.85Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8XVUCXCL28XVU-CXCR2-CXCL2
3.85Single8XWFCXCL38XWF-CXCR2-CXCL3
3.85Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.85Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.85Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
3.85Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
3.85Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
3.85Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single5EE7MK08935EE7-Glucagon-MK0893
3.70Single6KNMJN241-96KNM-Apelin-JN241-9
3.70Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
3.70Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.70Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.70Single7XN9L-054,5227XN9-SST2-L-054,522
3.70Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
3.70Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
3.70Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
3.70Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
3.70Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
3.70Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
3.70Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
3.70Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
3.57Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.57Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.57Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
3.57Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.57Single8KIGSHU91198KIG-MC3-SHU9119-Ca
3.57Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
3.57Single8XWNCXCL88XWN-CXCR2-CXCL8
3.57Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
3.57Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.45Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
3.45Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
3.45Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
3.45Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.45Single7SHEPI; PE7SHE-GPR158-PI; PE
3.45Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
3.45Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
3.45Single7XNACYN1548067XNA-SST2-CYN154806
3.45Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.45Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
3.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
3.33Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
3.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
3.33Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
3.33Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
3.33Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.23Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.23Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.23Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
3.23Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
3.12Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
3.12Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.12Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
3.12Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
3.12Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
3.12Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
3.12Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
3.12Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
3.12Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
3.03Single6FJ3PTH6FJ3-PTH1-PTH
3.03Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.03Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.03Single7SK3CXCL127SK3-ACKR3-CXCL12
3.03Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
3.03Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
2.86Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
2.70Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ

PDB Summary
PDB 9DQH
Class A
SubFamily Orphan
Type Orphan
SubType MRGPRD
Species Homo Sapiens
Ligand EP-2825
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.92
Date 2024-12-11 
D.O.I. 10.1016/j.celrep.2024.114942
Net Summary
Imin 3.28
Number of Linked Nodes 802
Number of Links 946
Number of Hubs 147
Number of Links mediated by Hubs 549
Number of Communities 26
Number of Nodes involved in Communities 213
Number of Links involved in Communities 297
Path Summary
Number Of Nodes in MetaPath 105
Number Of Links MetaPath 104
Number of Shortest Paths 3255006
Length Of Smallest Path 3
Average Path Length 39.9518
Length of Longest Path 70
Minimum Path Strength 1.16
Average Path Strength 7.11962
Maximum Path Strength 24.895
Minimum Path Correlation 0.7
Average Path Correlation 0.9914
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 38.4582
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.0469
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeA1B
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeA1B
Name1-deoxy-alpha-L-xylulofuranose-1,2-borate
Synonyms
Identifier
FormulaC5 H10 B O6
Molecular Weight176.94
SMILES
PubChem118797262
Formal Charge-1
Total Atoms22
Total Chiral Atoms3
Total Bonds23
Total Aromatic Bonds0



PDBsumOpen PDBsum Page
This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9DQJAOrphanOrphanMRGPRDHomo sapiensEP-3945-chim(NtGi1-Gs-CtGq)/β1/γ22.92024-12-1110.1016/j.celrep.2024.114942
9DQHAOrphanOrphanMRGPRDHomo sapiensEP-2825-chim(NtGi1-Gs-CtGq)/β1/γ22.922024-12-1110.1016/j.celrep.2024.114942
7Y14AOrphanOrphanMRGPRDHomo sapiensβ-Alanine--3.22022-07-2010.1038/s42003-022-03668-3
7Y13AOrphanOrphanMRGPRDHomo sapiens---3.12022-07-2010.1038/s42003-022-03668-3
7Y15AOrphanOrphanMRGPRDHomo sapiens--Gi1/β1/γ22.92022-07-2010.1038/s42003-022-03668-3
7Y12AOrphanOrphanMRGPRDHomo sapiensβ-Alanine-Gi1/β1/γ23.12022-07-2010.1038/s42003-022-03668-3




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