psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H24	R:R:L28	12.86	No	No	0	1	4
2	R:R:E86	R:R:Y27	3.37	Yes	No	0	3	3
3	R:R:V255	R:R:Y27	3.79	No	No	0	1	3
4	R:R:S259	R:R:Y27	3.82	No	No	0	3	3
5	R:R:L30	R:R:S259	6.01	No	No	0	5	3
6	R:R:L83	R:R:S31	6.01	No	No	0	6	3
7	R:R:L263	R:R:L33	4.15	No	No	0	5	5
8	R:R:C40	R:R:F36	5.59	No	No	0	6	5
9	R:R:S266	R:R:T37	3.2	No	No	0	6	7
10	R:R:S270	R:R:T37	4.8	No	No	0	8	7
11	R:R:A80	R:R:C38	3.61	No	No	0	6	6
12	R:R:G41	R:R:S270	3.71	No	No	0	9	8
13	R:R:L73	R:R:M42	4.24	No	No	0	7	7
14	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
15	R:R:N45	R:R:P273	11.4	No	No	0	9	9
16	R:R:A69	R:R:V48	3.39	No	No	0	9	9
17	R:R:F277	R:R:V48	9.18	Yes	No	0	7	9
18	R:R:A69	R:R:I49	3.25	No	No	0	9	7
19	R:R:F277	R:R:L51	4.87	Yes	No	0	7	7
20	R:R:L52	R:R:M56	5.65	Yes	Yes	7	8	7
21	R:R:C62	R:R:L52	7.94	No	Yes	0	8	8
22	R:R:L52	R:R:L66	4.15	Yes	No	0	8	8
23	R:R:F277	R:R:L52	4.87	Yes	Yes	7	7	8
24	R:R:G53	R:R:L66	3.42	No	No	0	6	8
25	R:R:F277	R:R:M56	3.73	Yes	Yes	7	7	7
26	R:R:M56	R:R:R283	7.44	Yes	No	0	7	6
27	R:R:H57	R:R:I63	5.3	No	No	0	6	7
28	R:R:P60	R:R:R58	8.65	Yes	No	1	7	7
29	R:R:R139	R:R:R58	3.2	No	No	1	5	7
30	R:R:N59	R:R:P60	4.89	No	Yes	0	8	7
31	R:R:F61	R:R:N59	6.04	Yes	No	0	8	8
32	R:R:C62	R:R:N59	4.72	No	No	0	8	8
33	R:R:F133	R:R:P60	5.78	Yes	Yes	1	7	7
34	R:R:P60	R:R:R137	4.32	Yes	Yes	1	7	9
35	R:R:P60	R:R:R139	8.65	Yes	No	1	7	5
36	R:R:F61	R:R:Q122	14.05	Yes	Yes	1	8	9
37	R:R:F61	R:R:S126	5.28	Yes	No	1	8	8
38	R:R:F133	R:R:F61	7.5	Yes	Yes	1	7	8
39	R:R:A118	R:R:Y64	4	No	Yes	0	8	8
40	R:R:I119	R:R:Y64	3.63	Yes	Yes	0	9	8
41	R:R:Q122	R:R:Y64	12.4	Yes	Yes	0	9	8
42	R:R:S142	R:R:Y64	11.45	No	Yes	0	9	8
43	R:R:V145	R:R:Y64	8.83	No	Yes	0	6	8
44	R:R:C146	R:R:Y64	4.03	No	Yes	0	7	8
45	R:R:C146	R:R:N67	11.02	No	No	0	7	9
46	R:R:N67	R:R:W150	5.65	No	Yes	0	9	9
47	R:R:D72	R:R:L68	8.14	Yes	Yes	3	9	9
48	R:R:L115	R:R:L68	4.15	No	Yes	0	7	9
49	R:R:L116	R:R:L68	5.54	No	Yes	3	9	9
50	R:R:I119	R:R:L68	4.28	Yes	Yes	3	9	9
51	R:R:L68	R:R:N272	6.87	Yes	Yes	3	9	9
52	R:R:L68	R:R:Y276	3.52	Yes	Yes	3	9	9
53	R:R:D72	R:R:S269	8.83	Yes	No	0	9	9
54	R:R:D72	R:R:N272	6.73	Yes	Yes	3	9	9
55	R:R:A108	R:R:L74	4.73	No	No	0	7	6
56	R:R:F75	R:R:M79	4.98	Yes	Yes	2	6	5
57	R:R:F75	R:R:M105	4.98	Yes	Yes	2	6	4
58	R:R:F75	R:R:Y109	5.16	Yes	Yes	2	6	8
59	R:R:F75	R:R:S265	3.96	Yes	No	2	6	8
60	R:R:F75	R:R:S269	5.28	Yes	No	0	6	9
61	R:R:L76	R:R:S269	4.5	No	No	0	7	9
62	R:R:L104	R:R:S78	6.01	No	No	0	5	5
63	R:R:M105	R:R:M79	13	Yes	Yes	2	4	5
64	R:R:M79	R:R:R262	4.96	Yes	Yes	0	5	4
65	R:R:M79	R:R:S266	4.6	Yes	No	0	5	6
66	R:R:M101	R:R:S81	7.67	No	No	0	4	5
67	R:R:E86	R:R:T82	4.23	Yes	No	0	3	3
68	R:R:M105	R:R:T82	4.52	Yes	No	0	4	3
69	R:R:L83	R:R:R262	8.5	No	Yes	0	6	4
70	R:R:H98	R:R:L85	6.43	No	No	0	5	3
71	R:R:E86	R:R:H98	7.39	Yes	No	0	3	5
72	R:R:E86	R:R:R262	5.82	Yes	Yes	0	3	4
73	R:R:Q88	R:R:T87	4.25	No	No	0	4	4
74	R:R:L90	R:R:T94	5.9	No	No	0	1	1
75	R:R:D95	R:R:L90	4.07	No	No	0	1	1
76	R:R:H98	R:R:L90	5.14	No	No	0	5	1
77	R:R:T93	R:R:T94	4.71	No	No	0	2	1
78	R:R:D95	R:R:F167	5.97	No	No	0	1	1
79	R:R:F167	R:R:K96	4.96	No	No	0	1	1
80	R:R:E99	R:R:K102	6.75	Yes	No	5	5	3
81	R:R:E99	R:R:R103	6.98	Yes	Yes	5	5	4
82	R:R:E99	R:R:S165	10.06	Yes	No	5	5	3
83	R:R:E99	R:R:F167	8.16	Yes	No	0	5	1
84	R:R:K102	R:R:R103	7.43	No	Yes	5	3	4
85	R:R:K102	R:R:Y106	10.75	No	No	0	3	3
86	R:R:R103	R:R:S161	9.22	Yes	No	0	4	3
87	R:R:R103	R:R:S165	6.59	Yes	No	5	4	3
88	R:R:M105	R:R:Y106	4.79	Yes	No	0	4	3
89	R:R:W241	R:R:Y106	16.4	Yes	No	0	4	3
90	R:R:F107	R:R:W150	5.01	No	Yes	0	5	9
91	R:R:F107	R:R:L154	6.09	No	No	0	5	4
92	R:R:F107	R:R:N157	10.87	No	No	0	5	7
93	R:R:L113	R:R:Y109	10.55	No	Yes	0	8	8
94	R:R:L237	R:R:Y109	10.55	Yes	Yes	2	5	8
95	R:R:S238	R:R:Y109	3.82	No	Yes	0	7	8
96	R:R:W241	R:R:Y109	3.86	Yes	Yes	2	4	8
97	R:R:S265	R:R:Y109	6.36	No	Yes	2	8	8
98	R:R:C153	R:R:T110	3.38	No	No	0	8	6
99	R:R:V111	R:R:W150	13.48	No	Yes	0	7	9
100	R:R:C153	R:R:V111	5.12	No	No	0	8	7
101	R:R:G112	R:R:L115	3.42	No	No	0	9	7
102	R:R:L113	R:R:S234	4.5	No	No	0	8	7
103	R:R:L149	R:R:S114	6.01	No	No	0	7	7
104	R:R:C153	R:R:S114	3.44	No	No	0	8	7
105	R:R:L116	R:R:N272	8.24	No	Yes	3	9	9
106	R:R:L116	R:R:Y276	4.69	No	Yes	3	9	9
107	R:R:L190	R:R:T117	8.84	No	No	0	8	8
108	R:R:M194	R:R:T117	4.52	No	No	0	8	8
109	R:R:I119	R:R:Y276	7.25	Yes	Yes	3	9	9
110	R:R:M194	R:R:S120	6.13	No	No	0	8	9
111	R:R:S120	R:R:S198	3.26	No	No	0	9	8
112	R:R:S197	R:R:T121	6.4	No	No	0	8	6
113	R:R:F133	R:R:Q122	7.03	Yes	Yes	1	7	9
114	R:R:Q122	R:R:R137	5.84	Yes	Yes	1	9	9
115	R:R:R123	R:R:Y276	8.23	No	Yes	0	9	9
116	R:R:C124	R:R:S197	5.16	No	No	0	8	8
117	R:R:C124	R:R:T200	3.38	No	No	0	8	5
118	R:R:S126	R:R:V127	3.23	No	No	0	8	8
119	R:R:F133	R:R:S126	7.93	Yes	No	1	7	8
120	R:R:L201	R:R:V127	4.47	No	No	0	8	8
121	R:R:V127	R:R:W204	3.68	No	Yes	0	8	6
122	R:R:F129	R:R:L128	4.87	No	No	0	5	6
123	R:R:L128	R:R:T200	4.42	No	No	0	6	5
124	R:R:L128	R:R:W204	6.83	No	Yes	0	6	6
125	R:R:F133	R:R:W132	4.01	Yes	No	1	7	6
126	R:R:H136	R:R:W132	4.23	No	No	0	6	6
127	R:R:R137	R:R:W132	13	Yes	No	1	9	6
128	R:R:F133	R:R:R137	8.55	Yes	Yes	1	7	9
129	R:R:C135	R:R:H136	5.9	No	No	0	7	6
130	R:R:R137	R:R:R139	3.2	Yes	No	1	9	5
131	R:R:L141	R:R:R137	10.93	No	Yes	1	5	9
132	R:R:R137	R:R:S142	6.59	Yes	No	0	9	9
133	R:R:L141	R:R:P138	6.57	No	No	1	5	8
134	R:R:P138	R:R:W144	4.05	No	No	1	8	5
135	R:R:L141	R:R:W144	7.97	No	No	1	5	5
136	R:R:L148	R:R:L152	4.15	No	No	0	5	6
137	R:R:M156	R:R:Q182	12.23	No	Yes	0	4	6
138	R:R:N157	R:R:T160	4.39	No	No	0	7	4
139	R:R:F163	R:R:L159	3.65	No	No	0	4	6
140	R:R:Q182	R:R:T160	5.67	Yes	No	0	6	4
141	R:R:F163	R:R:R174	16.03	No	No	0	4	1
142	R:R:C164	R:R:C175	7.28	No	No	0	6	8
143	R:R:F170	R:R:K166	9.93	No	No	0	1	3
144	R:R:N171	R:R:R174	16.87	No	No	0	5	1
145	R:R:C175	R:R:Y245	4.03	No	Yes	0	8	4
146	R:R:F176	R:R:M180	11.2	No	Yes	4	2	3
147	R:R:F176	R:R:Y245	7.22	No	Yes	4	2	4
148	R:R:F176	R:R:W246	10.02	No	No	4	2	4
149	R:R:D179	R:R:Y245	9.2	No	Yes	0	3	4
150	R:R:F242	R:R:M180	6.22	No	Yes	4	5	3
151	R:R:M180	R:R:Y245	4.79	Yes	Yes	4	3	4
152	R:R:M180	R:R:W246	6.98	Yes	No	4	3	4
153	R:R:Q182	R:R:W241	6.57	Yes	Yes	0	6	4
154	R:R:I186	R:R:S238	4.64	No	No	0	7	7
155	R:R:G188	R:R:M187	3.49	No	No	0	5	7
156	R:R:G188	R:R:P192	4.06	No	No	0	5	5
157	R:R:P192	R:R:T191	3.5	No	No	0	5	5
158	R:R:L235	R:R:T191	4.42	No	No	0	6	5
159	R:R:F230	R:R:M194	16.17	No	No	0	9	8
160	R:R:L231	R:R:T195	4.42	No	No	0	8	4
161	R:R:S198	R:R:V227	3.23	No	No	0	8	8
162	R:R:F202	R:R:F220	18.22	No	Yes	0	5	5
163	R:R:F202	R:R:V223	3.93	No	No	0	5	8
164	R:R:R207	R:R:W204	10	No	Yes	8	5	6
165	R:R:S208	R:R:W204	3.71	No	Yes	8	5	6
166	R:R:P216	R:R:V205	5.3	No	No	0	7	6
167	R:R:L219	R:R:V205	10.43	No	No	0	7	6
168	R:R:F220	R:R:V205	5.24	Yes	No	0	5	6
169	R:R:Q210	R:R:R206	8.18	Yes	No	9	5	5
170	R:R:F220	R:R:R206	4.28	Yes	No	9	5	5
171	R:R:R207	R:R:S208	11.86	No	No	8	5	5
172	R:R:R213	R:R:S209	7.91	No	No	0	5	7
173	R:R:Q210	R:R:Q215	16.64	Yes	No	0	5	5
174	R:R:P216	R:R:Q210	6.32	No	Yes	0	7	5
175	R:R:F220	R:R:Q210	12.88	Yes	Yes	9	5	5
176	R:R:Q211	R:R:W212	3.29	No	No	0	5	3
177	R:R:R218	R:R:V279	3.92	No	No	0	7	7
178	R:R:S268	R:R:V229	3.23	No	No	0	9	7
179	R:R:F230	R:R:L231	3.65	No	No	0	9	8
180	R:R:C233	R:R:V267	3.42	No	No	0	7	5
181	R:R:S234	R:R:S268	6.52	No	No	0	7	9
182	R:R:P236	R:R:S261	3.56	No	No	0	9	5
183	R:R:P236	R:R:S264	5.34	No	No	0	9	7
184	R:R:L237	R:R:W241	5.69	Yes	Yes	2	5	4
185	R:R:L237	R:R:S261	6.01	Yes	No	0	5	5
186	R:R:L237	R:R:S265	7.51	Yes	No	2	5	8
187	R:R:C257	R:R:Y240	6.72	No	Yes	0	4	3
188	R:R:F258	R:R:Y240	10.32	No	Yes	0	3	3
189	R:R:S261	R:R:Y240	3.82	No	Yes	0	5	3
190	R:R:F242	R:R:W246	4.01	No	No	4	5	4
191	R:R:L247	R:R:L249	4.15	No	Yes	0	3	3
192	R:R:L249	R:R:P250	4.93	Yes	No	10	3	1
193	R:R:L249	R:R:M253	5.65	Yes	No	10	3	1
194	R:R:M253	R:R:P250	6.71	No	No	10	1	1
195	R:R:F258	R:R:R262	20.31	No	Yes	0	3	4
196	R:R:N272	R:R:Y276	5.81	Yes	Yes	3	9	9
197	R:R:I275	R:R:Y276	6.04	No	Yes	0	8	9
198	R:R:T22	R:R:V23	3.17	No	No	0	1	1
199	R:R:C38	R:R:L76	3.17	No	No	0	6	7
200	R:R:T117	R:R:V193	3.17	No	No	0	8	6
201	R:R:H140	R:R:W144	3.17	No	No	0	5	5
202	R:R:T160	R:R:V178	3.17	No	No	0	4	4
203	R:R:P89	R:R:Q88	3.16	No	No	0	3	4
204	R:R:P251	R:R:Q254	3.16	No	No	0	2	2
205	R:R:T22	R:R:T25	3.14	No	No	0	1	2
206	R:R:I63	R:R:S142	3.1	No	No	0	7	9
207	R:R:M35	R:R:S84	3.07	No	No	0	4	5
208	R:R:M101	R:R:S78	3.07	No	No	0	4	5
209	R:R:L73	R:R:S46	3	No	No	0	7	6
210	R:R:L74	R:R:S78	3	No	No	0	6	5
211	R:R:L190	R:R:S114	3	No	No	0	8	7
212	R:R:L168	R:R:S165	3	No	No	0	1	3
213	R:R:L201	R:R:V223	2.98	No	No	0	8	8
214	R:R:L125	R:R:T121	2.95	No	No	0	6	6
215	R:R:I232	R:R:L228	2.85	No	No	0	5	6
216	R:R:A108	R:R:F75	2.77	No	Yes	0	7	6
217	R:R:A183	R:R:F242	2.77	No	No	0	5	5
218	R:R:L73	R:R:N45	2.75	No	No	0	7	9
219	R:R:A71	R:R:W150	2.59	No	Yes	0	9	9
220	R:R:F230	R:R:T191	2.59	No	No	0	9	5
221	R:R:S226	R:R:Y276	2.54	No	Yes	0	7	9
222	R:R:F77	R:R:M42	2.49	No	No	0	4	7
223	R:R:F77	R:R:M101	2.49	No	No	0	4	4
224	R:R:M56	R:R:R55	2.48	Yes	No	0	7	6
225	R:R:M47	R:R:W50	2.33	No	No	0	6	6
226	R:R:L51	R:R:W50	2.28	No	No	0	7	6
227	R:R:C40	R:R:G41	1.96	No	No	0	6	9
228	R:R:C146	R:R:G147	1.96	No	No	0	7	5
229	R:R:A43	R:R:G44	1.95	No	No	0	5	9
230	R:R:P250	R:R:P251	1.95	No	No	0	1	2
231	R:R:G280	R:R:V279	1.84	No	No	0	9	7
232	R:R:P216	R:R:S209	1.78	No	No	0	7	7
233	R:R:P89	R:R:V91	1.77	No	No	0	3	4
234	R:R:G44	R:R:M47	1.75	No	No	0	9	6
235	R:R:C233	R:R:S264	1.72	No	No	0	7	7
236	R:R:C233	R:R:S268	1.72	No	No	0	7	9
237	R:R:A34	R:R:S266	1.71	No	No	0	6	6
238	R:R:I131	R:R:P130	1.69	No	No	0	7	9
239	R:R:C135	R:R:I131	1.64	No	No	0	7	7
240	R:R:S281	R:R:S284	1.63	No	No	0	7	5
241	R:R:A80	R:R:M35	1.61	No	No	0	6	4
242	R:R:V23	R:R:V255	1.6	No	No	6	1	1
243	R:R:V222	R:R:V279	1.6	No	No	0	7	7
244	R:R:T25	R:R:V29	1.59	No	No	0	2	4
245	R:R:T217	R:R:V221	1.59	No	No	0	5	6
246	R:R:A26	R:R:L256	1.58	No	No	0	3	2
247	R:R:A34	R:R:L263	1.58	No	No	0	6	5
248	R:R:M56	R:R:S284	1.53	Yes	No	0	7	5
249	R:R:F54	R:R:G53	1.51	No	No	0	6	6
250	R:R:L168	R:R:S162	1.5	No	No	0	1	3
251	R:R:L256	R:R:V23	1.49	No	No	6	2	1
252	R:R:L159	R:R:V178	1.49	No	No	0	6	4
253	R:R:L190	R:R:V189	1.49	No	No	0	8	5
254	R:R:L199	R:R:V203	1.49	No	No	0	5	5
255	R:R:L249	R:R:V243	1.49	Yes	No	0	3	5
256	R:R:L256	R:R:V255	1.49	No	No	6	2	1
257	R:R:I119	R:R:I65	1.47	Yes	No	0	9	8
258	R:R:A143	R:R:H140	1.46	No	No	0	5	5
259	R:R:I186	R:R:L185	1.43	No	No	0	7	5
260	R:R:I239	R:R:L235	1.43	No	No	0	6	6
261	R:R:L39	R:R:M42	1.41	No	No	0	6	7
262	R:R:C164	R:R:F170	1.4	No	No	0	6	1
263	R:R:H285	R:R:S281	1.39	No	No	0	4	7
264	R:R:L260	R:R:L30	1.38	No	No	0	4	5
265	R:R:L155	R:R:L159	1.38	No	No	0	4	6
266	R:R:H24	R:R:T22	1.37	No	No	0	1	1
267	R:R:L244	R:R:Q254	1.33	No	No	0	3	2
268	R:R:E172	R:R:N171	1.31	No	No	0	3	5
269	R:R:R177	R:R:V181	1.31	No	No	0	3	3
270	R:R:D179	R:R:Q182	1.31	No	Yes	0	3	6
271	R:R:V243	R:R:Y240	1.26	No	Yes	0	5	3
272	R:R:M180	R:R:R177	1.24	Yes	No	0	3	3
273	R:R:F277	R:R:L278	1.22	Yes	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L52	5.6525	4	7	8
2	R:R:M56	4.166	5	7	7
3	R:R:P60	6.458	5	1	7
4	R:R:F61	8.2175	4	1	8
5	R:R:Y64	7.39	6	0	8
6	R:R:L68	5.41667	6	3	9
7	R:R:D72	7.6075	4	3	9
8	R:R:F75	4.52167	6	2	6
9	R:R:M79	6.885	4	2	5
10	R:R:E86	5.2025	4	0	3
11	R:R:E99	7.9875	4	5	5
12	R:R:R103	7.555	4	5	4
13	R:R:M105	6.8225	4	2	4
14	R:R:Y109	6.71667	6	2	8
15	R:R:I119	4.1575	4	3	9
16	R:R:Q122	9.83	4	1	9
17	R:R:F133	6.8	6	1	7
18	R:R:R137	7.49	7	1	9
19	R:R:W150	6.6825	4	0	9
20	R:R:M180	6.086	5	4	3
21	R:R:Q182	6.445	4	0	6
22	R:R:W204	6.055	4	8	6
23	R:R:Q210	11.005	4	9	5
24	R:R:F220	10.155	4	9	5
25	R:R:L237	7.44	4	2	5
26	R:R:Y240	5.53	4	0	3
27	R:R:W241	8.13	4	2	4
28	R:R:Y245	6.31	4	4	4
29	R:R:L249	4.055	4	10	3
30	R:R:R262	9.8975	4	0	4
31	R:R:N272	6.9125	4	3	9
32	R:R:Y276	5.44	7	3	9
33	R:R:F277	4.774	5	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E86	R:R:Y27	27.5973	3.37	Yes	No	0	3	3
2	R:R:V255	R:R:Y27	19.5131	3.79	No	No	0	1	3
3	R:R:V23	R:R:V255	13.2452	1.6	No	No	6	1	1
4	R:R:T22	R:R:V23	11.1127	3.17	No	No	0	1	1
5	R:R:E86	R:R:R262	19.0243	5.82	Yes	Yes	0	3	4
6	R:R:M79	R:R:R262	30.0029	4.96	Yes	Yes	0	5	4
7	R:R:M79	R:R:S266	14.5678	4.6	Yes	No	0	5	6
8	R:R:F75	R:R:S269	92.6826	5.28	Yes	No	0	6	9
9	R:R:F75	R:R:M79	38.5087	4.98	Yes	Yes	2	6	5
10	R:R:F75	R:R:M105	27.995	4.98	Yes	Yes	2	6	4
11	R:R:M105	R:R:T82	22.7621	4.52	Yes	No	0	4	3
12	R:R:E86	R:R:T82	21.8564	4.23	Yes	No	0	3	3
13	R:R:D72	R:R:S269	93.2289	8.83	Yes	No	0	9	9
14	R:R:D72	R:R:N45	11.5392	6.73	Yes	No	0	9	9
15	R:R:F277	R:R:L52	13.1733	4.87	Yes	Yes	7	7	8
16	R:R:C62	R:R:L52	25.7763	7.94	No	Yes	0	8	8
17	R:R:C62	R:R:N59	26.9743	4.72	No	No	0	8	8
18	R:R:F61	R:R:N59	25.7715	6.04	Yes	No	0	8	8
19	R:R:F61	R:R:Q122	50.2636	14.05	Yes	Yes	1	8	9
20	R:R:Q122	R:R:Y64	100	12.4	Yes	Yes	0	9	8
21	R:R:I119	R:R:Y64	93.3583	3.63	Yes	Yes	0	9	8
22	R:R:I119	R:R:L68	89.0598	4.28	Yes	Yes	3	9	9
23	R:R:D72	R:R:L68	91.3073	8.14	Yes	Yes	3	9	9
24	R:R:S142	R:R:Y64	17.8072	11.45	No	Yes	0	9	8
25	R:R:F133	R:R:Q122	34.8237	7.03	Yes	Yes	1	7	9
26	R:R:Q122	R:R:R137	14.5342	5.84	Yes	Yes	1	9	9
27	R:R:R137	R:R:S142	15.6699	6.59	Yes	No	0	9	9
28	R:R:F61	R:R:S126	29.9358	5.28	Yes	No	1	8	8
29	R:R:F133	R:R:S126	29.3703	7.93	Yes	No	1	7	8
30	R:R:C146	R:R:Y64	37.1142	4.03	No	Yes	0	7	8
31	R:R:C146	R:R:N67	35.2549	11.02	No	No	0	7	9
32	R:R:M105	R:R:Y106	20.4428	4.79	Yes	No	0	4	3
33	R:R:W241	R:R:Y106	14.6348	16.4	Yes	No	0	4	3
34	R:R:Q182	R:R:W241	28.4359	6.57	Yes	Yes	0	6	4
35	R:R:Q182	R:R:T160	30.7217	5.67	Yes	No	0	6	4
36	R:R:N157	R:R:T160	31.3446	4.39	No	No	0	7	4
37	R:R:F107	R:R:N157	31.4597	10.87	No	No	0	5	7
38	R:R:F107	R:R:W150	31.8143	5.01	No	Yes	0	5	9
39	R:R:N67	R:R:W150	34.8045	5.65	No	Yes	0	9	9
40	R:R:F75	R:R:Y109	29.9022	5.16	Yes	Yes	2	6	8
41	R:R:F75	R:R:S265	12.1047	3.96	Yes	No	2	6	8
42	R:R:E86	R:R:H98	12.6797	7.39	Yes	No	0	3	5
43	R:R:K102	R:R:Y106	16.7529	10.75	No	No	0	3	3
44	R:R:L237	R:R:Y109	11.4194	10.55	Yes	Yes	2	5	8
45	R:R:L237	R:R:S265	11.3954	7.51	Yes	No	2	5	8
46	R:R:F258	R:R:R262	10.8587	20.31	No	Yes	0	3	4
47	R:R:F258	R:R:Y240	10.3412	10.32	No	Yes	0	3	3
48	R:R:S261	R:R:Y240	19.9827	3.82	No	Yes	0	5	3
49	R:R:L237	R:R:S261	25.6613	6.01	Yes	No	0	5	5
50	R:R:C153	R:R:V111	28.6755	5.12	No	No	0	8	7
51	R:R:V111	R:R:W150	29.9358	13.48	No	Yes	0	7	9
52	R:R:C153	R:R:S114	26.1261	3.44	No	No	0	8	7
53	R:R:L190	R:R:S114	23.5384	3	No	No	0	8	7
54	R:R:L190	R:R:T117	20.9124	8.84	No	No	0	8	8
55	R:R:M194	R:R:T117	18.248	4.52	No	No	0	8	8
56	R:R:S126	R:R:V127	57.212	3.23	No	No	0	8	8
57	R:R:V127	R:R:W204	22.8196	3.68	No	Yes	0	8	6
58	R:R:L128	R:R:W204	16.2881	6.83	No	Yes	0	6	6
59	R:R:L128	R:R:T200	11.683	4.42	No	No	0	6	5
60	R:R:L201	R:R:V127	33.6832	4.47	No	No	0	8	8
61	R:R:R137	R:R:W132	10.9689	13	Yes	No	1	9	6
62	R:R:H136	R:R:W132	14.2946	4.23	No	No	0	6	6
63	R:R:C135	R:R:H136	10.7341	5.9	No	No	0	7	6
64	R:R:L141	R:R:R137	11.4913	10.93	No	Yes	1	5	9
65	R:R:T160	R:R:V178	10.1926	3.17	No	No	0	4	4
66	R:R:D179	R:R:Y245	18.2001	9.2	No	Yes	0	3	4
67	R:R:D179	R:R:Q182	19.5563	1.31	No	Yes	0	3	6
68	R:R:F230	R:R:M194	12.8043	16.17	No	No	0	9	8
69	R:R:F202	R:R:V223	29.8495	3.93	No	No	0	5	8
70	R:R:L201	R:R:V223	31.7711	2.98	No	No	0	8	8
71	R:R:F202	R:R:F220	27.5973	18.22	No	Yes	0	5	5
72	R:R:F220	R:R:V205	11.5536	5.24	Yes	No	0	5	6
73	R:R:F220	R:R:Q210	11.5152	12.88	Yes	Yes	9	5	5
74	R:R:V243	R:R:Y240	22.7909	1.26	No	Yes	0	5	3
75	R:R:L249	R:R:V243	19.9157	1.49	Yes	No	0	3	5
76	R:R:L249	R:R:P250	11.6638	4.93	Yes	No	10	3	1
77	R:R:W241	R:R:Y109	12.5264	3.86	Yes	Yes	2	4	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7Y13

PDB Summary
PDB	7Y13
Class	A
SubFamily	Orphan
Type	Orphan
SubType	MRGPRD
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.1
Date	2022-07-20
D.O.I.	doi.org/10.1038/s42003-022-03668-3

Net Summary
I_min	3.2
Number of Linked Nodes	244
Number of Links	273
Number of Hubs	33
Number of Links mediated by Hubs	120
Number of Communities	10
Number of Nodes involved in Communities	49
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	44117
Length Of Smallest Path	3
Average Path Length	14.0226
Length of Longest Path	28
Minimum Path Strength	1.275
Average Path Strength	6.16842
Maximum Path Strength	16.45
Minimum Path Correlation	0.7
Average Path Correlation	0.922807
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	43.7119
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.4501
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of systemic arterial blood pressure by renin-angiotensin • multicellular organismal process • regulation of systemic arterial blood pressure by hormone • system process • regulation of systemic arterial blood pressure mediated by a chemical signal • negative regulation of blood pressure • renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure • circulatory system process • angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of systemic arterial blood pressure • regulation of biological quality • blood vessel diameter maintenance • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • regulation of tube diameter • maintenance of blood vessel diameter homeostasis by renin-angiotensin • renal system process • regulation of blood pressure • regulation of tube size • regulation of systemic arterial blood pressure • endocrine process • vascular process in circulatory system • vasodilation • regulation of anatomical structure size • cellular anatomical structure • periplasmic space • cell periphery • plasma membrane • membrane • extracellular region • extracellular space
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS7
Sequence	>7Y13_Chain_R T V H T A Y L V L S S L A M F T C L C G M A G N S M V I W L L G F R M H R N P F C I Y I L N L A A A D L L F L F S M A S T L S L E T Q P L V N T T D K V H E L M K R L M Y F A Y T V G L S L L T A I S T Q R C L S V L F P I W F K C H R P R H L S A W V C G L L W T L C L L M N G L T S S F C S K F L K F N E D R C F R V D M V Q A A L I M G V L T P V M T L S S L T L F V W V R R S S Q Q W R R Q P T R L F V V V L A S V L V F L I C S L P L S I Y W F V L Y W L S L P P E M Q V L C F S L S R L S S S V S S S A N P V I Y F L V G S R R S H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9DQH	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.92	2024-12-11	doi.org/10.1016/j.celrep.2024.114942
	9DQH (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-		2.92	2024-12-11	doi.org/10.1016/j.celrep.2024.114942
	9DQJ	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-12-11	doi.org/10.1016/j.celrep.2024.114942
	9DQJ (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-		2.9	2024-12-11	doi.org/10.1016/j.celrep.2024.114942
	7Y12	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	Gi1/β1/γ2	3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y12 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-		3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y13	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	-	3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y14	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	-	3.2	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y15	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y15 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-		2.9	2022-07-20	doi.org/10.1038/s42003-022-03668-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y13.zip

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