Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L52 5.6525488
2R:R:M56 4.5875487
3R:R:P60 5.91417
4R:R:F61 8.2175418
5R:R:Y64 7.39608
6R:R:L68 5.41667649
7R:R:D72 7.6075449
8R:R:F75 4.52167626
9R:R:M79 6.885425
10R:R:E86 5.2025403
11R:R:E99 7.74535
12R:R:R103 7.555434
13R:R:M105 6.8225424
14R:R:Y109 6.71667628
15R:R:I119 4.1575449
16R:R:Q122 9.83419
17R:R:L128 4.8225456
18R:R:F133 6.8617
19R:R:R137 7.49719
20R:R:C146 5.045407
21R:R:W150 6.6825409
22R:R:F167 6.945431
23R:R:M180 6.086563
24R:R:Q182 6.445406
25R:R:W204 6.055456
26R:R:Q210 6.97495
27R:R:F220 7.8125495
28R:R:L237 7.44425
29R:R:Y240 5.53403
30R:R:W241 8.13424
31R:R:Y245 6.31464
32R:R:L249 4.0554103
33R:R:R262 9.8975404
34R:R:N272 6.9125449
35R:R:Y276 5.44749
36R:R:F277 4.774587
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E86 R:R:Y27 27.5683.37YesNo033
2R:R:V255 R:R:Y27 19.49963.79NoNo013
3R:R:V23 R:R:V255 13.24031.6NoNo711
4R:R:T22 R:R:V23 11.1093.17NoNo011
5R:R:E86 R:R:R262 19.13885.82YesYes034
6R:R:M79 R:R:S266 15.57854.6YesNo056
7R:R:M79 R:R:R262 30.39694.96YesYes054
8R:R:F75 R:R:S269 98.85015.28YesNo069
9R:R:F75 R:R:M79 39.73064.98YesYes265
10R:R:F75 R:R:M105 32.41764.98YesYes264
11R:R:M105 R:R:T82 22.08324.52YesNo043
12R:R:E86 R:R:T82 21.2224.23YesNo033
13R:R:D72 R:R:N45 11.62866.73YesNo099
14R:R:D72 R:R:S269 99.08118.83YesNo099
15R:R:F277 R:R:L52 13.61084.87YesYes878
16R:R:C62 R:R:L52 26.5487.94NoYes088
17R:R:C62 R:R:N59 27.78454.72NoNo088
18R:R:F61 R:R:N59 26.61056.04YesNo088
19R:R:F61 R:R:Q122 51.31114.05YesYes189
20R:R:Q122 R:R:Y64 10012.4YesYes098
21R:R:I119 R:R:Y64 89.76183.63YesYes098
22R:R:I119 R:R:L68 86.04284.28YesYes499
23R:R:D72 R:R:L68 96.45428.14YesYes499
24R:R:S142 R:R:Y64 17.50311.45NoYes098
25R:R:F133 R:R:Q122 34.16897.03YesYes179
26R:R:Q122 R:R:R137 14.08715.84YesYes199
27R:R:R137 R:R:S142 15.21296.59YesNo099
28R:R:F61 R:R:S126 29.9115.28YesNo188
29R:R:F133 R:R:S126 29.46847.93YesNo178
30R:R:C146 R:R:N67 35.602611.02YesNo079
31R:R:M105 R:R:Y106 25.28274.79YesNo043
32R:R:W241 R:R:Y106 17.358716.4YesNo043
33R:R:Q182 R:R:W241 29.20386.57YesYes064
34R:R:Q182 R:R:T160 30.28635.67YesNo064
35R:R:N157 R:R:T160 30.68564.39NoNo074
36R:R:F107 R:R:N157 30.781810.87NoNo057
37R:R:F107 R:R:W150 31.08975.01NoYes059
38R:R:F75 R:R:Y109 29.44435.16YesYes268
39R:R:F75 R:R:S265 12.57643.96YesNo268
40R:R:E86 R:R:H98 13.50497.39YesNo035
41R:R:E99 R:R:K102 18.09486.75YesNo353
42R:R:K102 R:R:Y106 25.181610.75NoNo033
43R:R:E99 R:R:F167 10.78668.16YesYes351
44R:R:L237 R:R:Y109 11.907610.55YesYes258
45R:R:L237 R:R:S265 11.87887.51YesNo258
46R:R:L237 R:R:S261 27.17836.01YesNo055
47R:R:S261 R:R:Y240 21.56363.82NoYes053
48R:R:F258 R:R:Y240 11.368810.32NoYes033
49R:R:F258 R:R:R262 11.89820.31NoYes034
50R:R:C153 R:R:V111 31.01275.12NoNo087
51R:R:V111 R:R:W150 32.383913.48NoYes079
52R:R:C153 R:R:S114 28.24153.44NoNo087
53R:R:L190 R:R:S114 25.43183NoNo087
54R:R:L190 R:R:T117 22.58368.84NoNo088
55R:R:M194 R:R:T117 19.69694.52NoNo088
56R:R:L128 R:R:W204 16.8926.83YesYes566
57R:R:V127 R:R:W204 23.66613.68NoYes086
58R:R:S126 R:R:V127 57.19033.23NoNo088
59R:R:L201 R:R:V127 32.62934.47NoNo088
60R:R:R137 R:R:W132 11.373613YesNo196
61R:R:H136 R:R:W132 14.75584.23NoNo066
62R:R:C135 R:R:H136 11.08015.9NoNo076
63R:R:L141 R:R:R137 11.869110.93NoYes159
64R:R:D179 R:R:Y245 17.26249.2NoYes034
65R:R:D179 R:R:Q182 18.66251.31NoYes036
66R:R:F230 R:R:M194 13.80816.17NoNo098
67R:R:F202 R:R:V223 28.6363.93NoNo058
68R:R:L201 R:R:V223 30.63752.98NoNo088
69R:R:F202 R:R:F220 26.288218.22NoYes055
70R:R:F220 R:R:V205 12.10015.24YesNo056
71R:R:L249 R:R:V243 22.63651.49YesNo035
72R:R:V243 R:R:Y240 25.48471.26NoYes053
73R:R:L249 R:R:P250 14.4724.93YesNo1031
74R:R:P250 R:R:P251 11.61411.95NoNo012
75R:R:W241 R:R:Y109 12.03753.86YesYes248
76R:R:N67 R:R:W150 35.01565.65NoYes099
77R:R:C146 R:R:Y64 31.2874.03YesYes078
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7Y13
Class A
SubFamily Orphan
Type A orphans
SubType MRGPRD
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.1
Date 2022-07-20
D.O.I. 10.1038/s42003-022-03668-3
Net Summary
Imin 3.17
Number of Linked Nodes 247
Number of Links 279
Number of Hubs 36
Number of Links mediated by Hubs 128
Number of Communities 10
Number of Nodes involved in Communities 54
Number of Links involved in Communities 73
Path Summary
Number Of Nodes in MetaPath 78
Number Of Links MetaPath 77
Number of Shortest Paths 45677
Length Of Smallest Path 3
Average Path Length 14.0192
Length of Longest Path 29
Minimum Path Strength 1.275
Average Path Strength 6.11733
Maximum Path Strength 16.45
Minimum Path Correlation 0.7
Average Path Correlation 0.924014
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 43.6276
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.7072
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TDS7
Sequence
>7Y13_Chain_R
TVHTAYLVL SSLAMFTCL CGMAGNSMV IWLLGFRMH RNPFCIYIL 
NLAAADLLF LFSMASTLS LETQPLVNT TDKVHELMK RLMYFAYTV 
GLSLLTAIS TQRCLSVLF PIWFKCHRP RHLSAWVCG LLWTLCLLM 
NGLTSSFCS KFLKFNEDR CFRVDMVQA ALIMGVLTP VMTLSSLTL 
FVWVRRSSQ QWRRQPTRL FVVVLASVL VFLICSLPL SIYWFVLYW 
LSLPPEMQV LCFSLSRLS SSVSSSANP VIYFLVGSR RSH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y12AOrphanA orphansMRGPRDHomo sapiensBeta-alanine-Gi1/&β;1/&γ;23.12022-07-2010.1038/s42003-022-03668-3
7Y13AOrphanA orphansMRGPRDHomo sapiens---3.12022-07-2010.1038/s42003-022-03668-3
7Y14AOrphanA orphansMRGPRDHomo sapiensBeta-alanine--3.22022-07-2010.1038/s42003-022-03668-3
7Y15AOrphanA orphansMRGPRDHomo sapiens--Gi1/&β;1/&γ;22.92022-07-2010.1038/s42003-022-03668-3




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y13.zip



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