psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T22	R:R:V23	3.17	No	No	0	1	1
2	R:R:T22	R:R:T25	3.14	No	No	0	1	2
3	R:R:E86	R:R:Y27	3.37	No	No	0	3	3
4	R:R:V255	R:R:Y27	5.05	No	No	0	1	3
5	R:R:L30	R:R:S259	9.01	No	No	0	5	3
6	R:R:C40	R:R:F36	5.59	No	No	0	6	5
7	R:R:S266	R:R:T37	6.4	No	No	0	6	7
8	R:R:S270	R:R:T37	4.8	No	No	0	8	7
9	R:R:C38	R:R:L76	4.76	No	No	0	6	7
10	R:R:C38	R:R:M79	3.24	No	Yes	0	6	5
11	R:R:A80	R:R:C38	3.61	No	No	0	6	6
12	R:R:G41	R:R:S270	3.71	No	No	0	9	8
13	R:R:F77	R:R:M42	3.73	No	No	0	4	7
14	R:R:D72	R:R:N45	6.73	Yes	No	0	9	9
15	R:R:N45	R:R:P273	9.77	No	No	0	9	9
16	R:R:A69	R:R:V48	3.39	No	No	0	9	9
17	R:R:F277	R:R:V48	7.87	Yes	No	0	7	9
18	R:R:L51	R:R:W50	4.56	No	No	0	7	6
19	R:R:F277	R:R:L51	3.65	Yes	No	0	7	7
20	R:R:C62	R:R:L52	9.52	No	Yes	0	8	8
21	R:R:L52	R:R:L66	5.54	Yes	No	0	8	8
22	R:R:F277	R:R:L52	4.87	Yes	Yes	0	7	8
23	R:R:M56	R:R:R55	3.72	Yes	No	0	7	6
24	R:R:C62	R:R:M56	3.24	No	Yes	0	8	7
25	R:R:M56	R:R:R283	6.2	Yes	No	0	7	6
26	R:R:M56	R:R:S284	4.6	Yes	No	0	7	5
27	R:R:H57	R:R:I63	6.63	No	No	0	6	7
28	R:R:R283	R:R:R58	7.46	No	No	0	6	7
29	R:R:N59	R:R:P60	4.89	No	Yes	1	8	7
30	R:R:F61	R:R:N59	3.62	Yes	No	1	8	8
31	R:R:C62	R:R:N59	4.72	No	No	0	8	8
32	R:R:F61	R:R:P60	4.33	Yes	Yes	1	8	7
33	R:R:F133	R:R:P60	5.78	Yes	Yes	1	7	7
34	R:R:P60	R:R:R137	5.76	Yes	Yes	1	7	9
35	R:R:F61	R:R:Q122	14.05	Yes	Yes	1	8	9
36	R:R:F61	R:R:S126	5.28	Yes	No	1	8	8
37	R:R:F133	R:R:F61	7.5	Yes	Yes	1	7	8
38	R:R:I63	R:R:S142	4.64	No	No	0	7	9
39	R:R:A118	R:R:Y64	4	No	Yes	0	8	8
40	R:R:I119	R:R:Y64	3.63	No	Yes	0	9	8
41	R:R:Q122	R:R:Y64	12.4	Yes	Yes	0	9	8
42	R:R:S142	R:R:Y64	11.45	No	Yes	0	9	8
43	R:R:V145	R:R:Y64	8.83	No	Yes	0	6	8
44	R:R:C146	R:R:Y64	4.03	No	Yes	0	7	8
45	R:R:L115	R:R:N67	4.12	No	No	0	7	9
46	R:R:C146	R:R:N67	12.6	No	No	0	7	9
47	R:R:N67	R:R:W150	5.65	No	Yes	0	9	9
48	R:R:D72	R:R:L68	5.43	Yes	Yes	2	9	9
49	R:R:L115	R:R:L68	4.15	No	Yes	0	7	9
50	R:R:L116	R:R:L68	5.54	No	Yes	2	9	9
51	R:R:L68	R:R:N272	5.49	Yes	Yes	2	9	9
52	R:R:D72	R:R:S269	10.31	Yes	No	0	9	9
53	R:R:D72	R:R:N272	6.73	Yes	Yes	2	9	9
54	R:R:A108	R:R:L74	4.73	No	No	0	7	6
55	R:R:F75	R:R:M105	6.22	Yes	No	0	6	4
56	R:R:F75	R:R:Y109	5.16	Yes	Yes	3	6	8
57	R:R:F75	R:R:S265	3.96	Yes	No	3	6	8
58	R:R:F75	R:R:S269	7.93	Yes	No	0	6	9
59	R:R:L76	R:R:S269	6.01	No	No	0	7	9
60	R:R:F77	R:R:S81	5.28	No	No	0	4	5
61	R:R:L104	R:R:S78	4.5	No	No	0	5	5
62	R:R:M105	R:R:S78	4.6	No	No	0	4	5
63	R:R:M105	R:R:M79	7.22	No	Yes	0	4	5
64	R:R:M79	R:R:R262	6.2	Yes	Yes	0	5	4
65	R:R:M79	R:R:S266	4.6	Yes	No	0	5	6
66	R:R:M101	R:R:S81	3.07	No	No	0	4	5
67	R:R:E86	R:R:T82	4.23	No	No	0	3	3
68	R:R:M101	R:R:T82	3.01	No	No	0	4	3
69	R:R:L83	R:R:R262	6.07	No	Yes	0	6	4
70	R:R:H98	R:R:L85	6.43	No	No	0	5	3
71	R:R:E86	R:R:R262	5.82	No	Yes	0	3	4
72	R:R:Q88	R:R:T87	5.67	No	No	0	4	4
73	R:R:P89	R:R:Q88	3.16	No	No	0	3	4
74	R:R:L90	R:R:T94	7.37	No	No	0	1	1
75	R:R:N92	R:R:T93	4.39	No	No	0	5	2
76	R:R:T93	R:R:T94	3.14	No	No	0	2	1
77	R:R:D95	R:R:K166	9.68	No	Yes	0	1	3
78	R:R:F167	R:R:K96	13.65	No	No	0	1	1
79	R:R:H98	R:R:K102	5.24	No	Yes	0	5	3
80	R:R:E99	R:R:K102	5.4	Yes	Yes	4	5	3
81	R:R:E99	R:R:R103	5.82	Yes	Yes	4	5	4
82	R:R:E99	R:R:S165	8.62	Yes	No	4	5	3
83	R:R:E99	R:R:K166	10.8	Yes	Yes	0	5	3
84	R:R:K102	R:R:R103	3.71	Yes	Yes	4	3	4
85	R:R:K102	R:R:Y106	3.58	Yes	No	0	3	3
86	R:R:R103	R:R:S161	7.91	Yes	No	0	4	3
87	R:R:R103	R:R:S165	6.59	Yes	No	4	4	3
88	R:R:W241	R:R:Y106	27.97	No	No	0	4	3
89	R:R:F107	R:R:W150	5.01	No	Yes	0	5	9
90	R:R:F107	R:R:L154	6.09	No	No	0	5	4
91	R:R:F107	R:R:N157	12.08	No	No	0	5	7
92	R:R:L113	R:R:Y109	14.07	No	Yes	0	8	8
93	R:R:L237	R:R:Y109	9.38	Yes	Yes	3	5	8
94	R:R:S238	R:R:Y109	3.82	Yes	Yes	0	7	8
95	R:R:W241	R:R:Y109	3.86	No	Yes	3	4	8
96	R:R:S265	R:R:Y109	5.09	No	Yes	3	8	8
97	R:R:C153	R:R:T110	5.07	No	Yes	0	8	6
98	R:R:N157	R:R:T110	4.39	No	Yes	0	7	6
99	R:R:Q182	R:R:T110	7.09	No	Yes	5	6	6
100	R:R:I186	R:R:T110	3.04	No	Yes	5	7	6
101	R:R:V111	R:R:W150	15.94	No	Yes	0	7	9
102	R:R:C153	R:R:V111	5.12	No	No	0	8	7
103	R:R:L113	R:R:S234	4.5	No	No	0	8	7
104	R:R:L149	R:R:S114	6.01	No	No	0	7	7
105	R:R:C153	R:R:S114	3.44	No	No	0	8	7
106	R:R:L116	R:R:N272	9.61	No	Yes	2	9	9
107	R:R:L116	R:R:Y276	4.69	No	Yes	2	9	9
108	R:R:L190	R:R:T117	8.84	No	No	0	8	8
109	R:R:T117	R:R:V193	3.17	No	No	0	8	6
110	R:R:M194	R:R:T117	3.01	Yes	No	0	8	8
111	R:R:I119	R:R:Y276	7.25	No	Yes	0	9	9
112	R:R:M194	R:R:S120	7.67	Yes	No	6	8	9
113	R:R:S120	R:R:S198	3.26	No	No	6	9	8
114	R:R:S197	R:R:T121	6.4	No	No	0	8	6
115	R:R:F133	R:R:Q122	7.03	Yes	Yes	1	7	9
116	R:R:Q122	R:R:R137	3.5	Yes	Yes	1	9	9
117	R:R:R123	R:R:Y276	7.2	No	Yes	0	9	9
118	R:R:C124	R:R:L128	3.17	No	No	0	8	6
119	R:R:C124	R:R:S197	3.44	No	No	0	8	8
120	R:R:C124	R:R:T200	3.38	No	No	0	8	5
121	R:R:S126	R:R:V127	3.23	No	No	0	8	8
122	R:R:F133	R:R:S126	7.93	Yes	No	1	7	8
123	R:R:L201	R:R:V127	4.47	No	No	0	8	8
124	R:R:F129	R:R:L128	6.09	No	No	0	5	6
125	R:R:L128	R:R:W204	11.39	No	No	0	6	6
126	R:R:H136	R:R:W132	5.29	No	No	0	6	6
127	R:R:R137	R:R:W132	10	Yes	No	0	9	6
128	R:R:F133	R:R:R137	9.62	Yes	Yes	1	7	9
129	R:R:C135	R:R:H136	7.37	No	No	0	7	6
130	R:R:L141	R:R:R137	3.64	No	Yes	0	5	9
131	R:R:R137	R:R:S142	6.59	Yes	No	0	9	9
132	R:R:L141	R:R:P138	6.57	No	No	0	5	8
133	R:R:H140	R:R:R139	21.44	No	No	0	5	5
134	R:R:H140	R:R:W144	3.17	No	No	0	5	5
135	R:R:L141	R:R:W144	6.83	No	No	0	5	5
136	R:R:M156	R:R:Q182	6.8	No	No	0	4	6
137	R:R:T160	R:R:V178	4.76	No	No	0	4	4
138	R:R:F163	R:R:R174	9.62	No	No	0	4	1
139	R:R:F163	R:R:V178	6.55	No	No	0	4	4
140	R:R:C164	R:R:C175	7.28	No	No	0	6	8
141	R:R:F170	R:R:K166	13.65	No	Yes	0	1	3
142	R:R:K169	R:R:N171	5.6	No	No	0	1	5
143	R:R:N171	R:R:R174	14.46	No	No	0	5	1
144	R:R:D173	R:R:R174	7.15	No	No	0	3	1
145	R:R:F176	R:R:R177	5.34	Yes	No	0	2	3
146	R:R:F176	R:R:M180	9.95	Yes	No	8	2	3
147	R:R:F176	R:R:Y245	4.13	Yes	Yes	8	2	4
148	R:R:F176	R:R:W246	3.01	Yes	No	0	2	4
149	R:R:D179	R:R:Y245	8.05	No	Yes	0	3	4
150	R:R:F242	R:R:M180	3.73	No	No	0	5	3
151	R:R:M180	R:R:Y245	3.59	No	Yes	8	3	4
152	R:R:I186	R:R:Q182	5.49	No	No	5	7	6
153	R:R:I186	R:R:S238	4.64	No	Yes	0	7	7
154	R:R:M187	R:R:T191	3.01	No	Yes	0	7	5
155	R:R:M187	R:R:S238	3.07	No	Yes	0	7	7
156	R:R:G188	R:R:P192	4.06	No	No	0	5	5
157	R:R:P192	R:R:T191	3.5	No	Yes	0	5	5
158	R:R:F230	R:R:T191	3.89	No	Yes	0	9	5
159	R:R:L235	R:R:T191	5.9	No	Yes	0	6	5
160	R:R:M194	R:R:S198	3.07	Yes	No	6	8	8
161	R:R:F230	R:R:M194	9.95	No	Yes	0	9	8
162	R:R:L231	R:R:T195	4.42	No	No	0	8	4
163	R:R:S198	R:R:V227	3.23	No	No	0	8	8
164	R:R:F202	R:R:F220	17.15	No	Yes	0	5	5
165	R:R:R207	R:R:W204	12	No	No	7	5	6
166	R:R:S208	R:R:W204	4.94	No	No	7	5	6
167	R:R:P216	R:R:V205	3.53	No	No	0	7	6
168	R:R:L219	R:R:V205	11.92	No	No	0	7	6
169	R:R:Q210	R:R:R206	9.35	No	No	9	5	5
170	R:R:F220	R:R:R206	4.28	Yes	No	9	5	5
171	R:R:R207	R:R:S208	9.22	No	No	7	5	5
172	R:R:R213	R:R:S209	6.59	No	No	0	5	7
173	R:R:Q210	R:R:Q215	15.36	No	No	0	5	5
174	R:R:F220	R:R:Q210	7.03	Yes	No	9	5	5
175	R:R:Q211	R:R:W212	7.67	No	No	0	5	3
176	R:R:V222	R:R:V279	4.81	No	No	10	7	7
177	R:R:S226	R:R:V227	3.23	No	No	0	7	8
178	R:R:S268	R:R:V229	3.23	Yes	No	0	9	7
179	R:R:F230	R:R:L231	3.65	No	No	0	9	8
180	R:R:C233	R:R:S268	3.44	No	Yes	0	7	9
181	R:R:S234	R:R:S268	6.52	No	Yes	0	7	9
182	R:R:P236	R:R:S261	3.56	No	No	0	9	5
183	R:R:P236	R:R:S264	5.34	No	No	0	9	7
184	R:R:L237	R:R:W241	5.69	Yes	No	3	5	4
185	R:R:L237	R:R:S261	4.5	Yes	No	0	5	5
186	R:R:L237	R:R:S265	6.01	Yes	No	3	5	8
187	R:R:L244	R:R:Y240	12.89	No	Yes	0	3	3
188	R:R:C257	R:R:Y240	5.38	No	Yes	0	4	3
189	R:R:F258	R:R:Y240	12.38	No	Yes	0	3	3
190	R:R:S261	R:R:Y240	3.82	No	Yes	0	5	3
191	R:R:F242	R:R:W246	4.01	No	No	0	5	4
192	R:R:L244	R:R:Q254	3.99	No	No	0	3	2
193	R:R:L247	R:R:L249	4.15	No	No	0	3	3
194	R:R:L249	R:R:P250	3.28	No	No	0	3	1
195	R:R:M253	R:R:P250	6.71	No	No	0	1	1
196	R:R:P251	R:R:Q254	4.74	No	No	0	2	2
197	R:R:F258	R:R:R262	18.17	No	Yes	0	3	4
198	R:R:N272	R:R:S268	4.47	Yes	Yes	0	9	9
199	R:R:N272	R:R:Y276	5.81	Yes	Yes	2	9	9
200	R:R:I275	R:R:V274	3.07	No	No	0	8	6
201	R:R:I275	R:R:Y276	6.04	No	Yes	0	8	9
202	R:R:S281	R:R:S284	4.89	No	No	0	7	5
203	R:R:H285	R:R:S281	5.58	No	No	0	4	7
204	R:R:L83	R:R:S31	3	No	No	0	6	3
205	R:R:L74	R:R:S78	3	No	No	0	6	5
206	R:R:L168	R:R:S162	3	No	No	0	1	3
207	R:R:L256	R:R:S259	3	Yes	No	0	2	3
208	R:R:L256	R:R:V23	2.98	Yes	No	0	2	1
209	R:R:L185	R:R:V189	2.98	No	No	0	5	5
210	R:R:L201	R:R:V223	2.98	No	No	0	8	8
211	R:R:L249	R:R:V243	2.98	No	No	0	3	5
212	R:R:I239	R:R:M187	2.92	No	No	0	6	7
213	R:R:F220	R:R:P216	2.89	Yes	No	0	5	7
214	R:R:K166	R:R:K96	2.87	Yes	No	0	3	1
215	R:R:I49	R:R:L66	2.85	No	No	0	7	8
216	R:R:I65	R:R:L52	2.85	No	Yes	0	8	8
217	R:R:I232	R:R:L228	2.85	No	No	0	5	6
218	R:R:L73	R:R:M42	2.83	No	No	0	7	7
219	R:R:L260	R:R:L30	2.77	No	No	0	4	5
220	R:R:L148	R:R:L152	2.77	No	No	0	5	6
221	R:R:A183	R:R:F242	2.77	No	No	0	5	5
222	R:R:D95	R:R:L90	2.71	No	No	0	1	1
223	R:R:C175	R:R:Y245	2.69	No	Yes	0	8	4
224	R:R:A71	R:R:W150	2.59	No	Yes	0	9	9
225	R:R:F129	R:R:L125	2.44	No	No	0	5	6
226	R:R:F277	R:R:L278	2.44	Yes	No	0	7	7
227	R:R:H24	R:R:Y27	2.18	No	No	0	1	3
228	R:R:C40	R:R:G41	1.96	No	No	0	6	9
229	R:R:C146	R:R:G147	1.96	No	No	0	7	5
230	R:R:A43	R:R:G44	1.95	No	No	0	5	9
231	R:R:A71	R:R:G112	1.95	No	No	0	9	9
232	R:R:P250	R:R:P251	1.95	No	No	0	1	2
233	R:R:G280	R:R:V279	1.84	No	No	0	9	7
234	R:R:P216	R:R:S209	1.78	No	No	0	7	7
235	R:R:G44	R:R:M47	1.75	No	No	0	9	6
236	R:R:A34	R:R:S266	1.71	No	No	0	6	6
237	R:R:G53	R:R:L66	1.71	No	No	0	6	8
238	R:R:A183	R:R:S238	1.71	No	Yes	0	5	7
239	R:R:C233	R:R:V267	1.71	No	No	0	7	5
240	R:R:C135	R:R:I131	1.64	No	No	0	7	7
241	R:R:S120	R:R:S197	1.63	No	No	0	9	8
242	R:R:A70	R:R:I49	1.62	No	No	0	5	7
243	R:R:A80	R:R:M35	1.61	No	No	0	6	4
244	R:R:V221	R:R:V222	1.6	No	No	0	6	7
245	R:R:T25	R:R:V29	1.59	No	No	0	2	4
246	R:R:A26	R:R:L256	1.58	No	Yes	0	3	2
247	R:R:A34	R:R:L263	1.58	No	No	0	6	5
248	R:R:M35	R:R:S84	1.53	No	No	0	4	5
249	R:R:M156	R:R:T160	1.51	No	No	0	4	4
250	R:R:L73	R:R:S46	1.5	No	No	0	7	6
251	R:R:L33	R:R:V29	1.49	No	No	0	5	4
252	R:R:L190	R:R:V189	1.49	No	No	0	8	5
253	R:R:L199	R:R:V203	1.49	No	No	0	5	5
254	R:R:L201	R:R:V205	1.49	No	No	0	8	6
255	R:R:L219	R:R:V223	1.49	No	No	0	7	8
256	R:R:L256	R:R:V255	1.49	Yes	No	0	2	1
257	R:R:F129	R:R:P130	1.44	No	No	0	5	9
258	R:R:Q215	R:R:T217	1.42	No	No	0	5	5
259	R:R:L39	R:R:M42	1.41	No	No	0	6	7
260	R:R:L51	R:R:M47	1.41	No	No	0	7	6
261	R:R:L224	R:R:L228	1.38	No	No	0	5	6
262	R:R:E252	R:R:M253	1.35	No	No	0	2	1
263	R:R:R218	R:R:V222	1.31	No	No	10	7	7
264	R:R:R218	R:R:V279	1.31	No	No	10	7	7
265	R:R:F167	R:R:L168	1.22	No	No	0	1	1
266	R:R:F202	R:R:L224	1.22	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L52	5.695	4	0	8
2	R:R:M56	4.44	4	0	7
3	R:R:P60	5.19	4	1	7
4	R:R:F61	6.956	5	1	8
5	R:R:Y64	7.39	6	0	8
6	R:R:L68	5.1525	4	2	9
7	R:R:D72	7.3	4	2	9
8	R:R:F75	5.8175	4	3	6
9	R:R:M79	5.315	4	0	5
10	R:R:E99	7.66	4	4	5
11	R:R:K102	4.4825	4	4	3
12	R:R:R103	6.0075	4	4	4
13	R:R:Y109	6.89667	6	3	8
14	R:R:T110	4.8975	4	5	6
15	R:R:Q122	9.245	4	1	9
16	R:R:F133	7.572	5	1	7
17	R:R:R137	6.51833	6	1	9
18	R:R:W150	7.2975	4	0	9
19	R:R:K166	9.25	4	0	3
20	R:R:F176	5.6075	4	8	2
21	R:R:T191	4.075	4	0	5
22	R:R:M194	5.925	4	6	8
23	R:R:F220	7.8375	4	9	5
24	R:R:L237	6.395	4	3	5
25	R:R:S238	3.31	4	0	7
26	R:R:Y240	8.6175	4	0	3
27	R:R:Y245	4.615	4	8	4
28	R:R:L256	2.2625	4	0	2
29	R:R:R262	9.065	4	0	4
30	R:R:S268	4.415	4	0	9
31	R:R:N272	6.422	5	2	9
32	R:R:Y276	6.198	5	2	9
33	R:R:F277	4.7075	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E86	R:R:Y27	16.435	3.37	No	No	0	3	3
2	R:R:V255	R:R:Y27	14.1189	5.05	No	No	0	1	3
3	R:R:L256	R:R:V255	13.0391	1.49	Yes	No	0	2	1
4	R:R:M79	R:R:R262	28.9783	6.2	Yes	Yes	0	5	4
5	R:R:E86	R:R:R262	27.0634	5.82	No	Yes	0	3	4
6	R:R:C38	R:R:M79	15.1334	3.24	No	Yes	0	6	5
7	R:R:C38	R:R:L76	16.0468	4.76	No	No	0	6	7
8	R:R:E86	R:R:T82	10.2988	4.23	No	No	0	3	3
9	R:R:D72	R:R:S269	64.6865	10.31	Yes	No	0	9	9
10	R:R:F75	R:R:S269	51.2103	7.93	Yes	No	0	6	9
11	R:R:F75	R:R:M105	27.8495	6.22	Yes	No	0	6	4
12	R:R:M105	R:R:M79	25.1093	7.22	No	Yes	0	4	5
13	R:R:L76	R:R:S269	16.5851	6.01	No	No	0	7	9
14	R:R:F277	R:R:L52	13.3262	4.87	Yes	Yes	0	7	8
15	R:R:C62	R:R:L52	21.9188	9.52	No	Yes	0	8	8
16	R:R:C62	R:R:N59	33.0104	4.72	No	No	0	8	8
17	R:R:F61	R:R:N59	33.1931	3.62	Yes	No	1	8	8
18	R:R:F61	R:R:Q122	58.4589	14.05	Yes	Yes	1	8	9
19	R:R:Q122	R:R:Y64	100	12.4	Yes	Yes	0	9	8
20	R:R:I119	R:R:Y64	83.5976	3.63	No	Yes	0	9	8
21	R:R:I119	R:R:Y276	84.0739	7.25	No	Yes	0	9	9
22	R:R:N272	R:R:Y276	85.9268	5.81	Yes	Yes	2	9	9
23	R:R:D72	R:R:N272	59.8845	6.73	Yes	Yes	2	9	9
24	R:R:C62	R:R:M56	10.4097	3.24	No	Yes	0	8	7
25	R:R:S142	R:R:Y64	18.102	11.45	No	Yes	0	9	8
26	R:R:F133	R:R:Q122	26.5805	7.03	Yes	Yes	1	7	9
27	R:R:Q122	R:R:R137	14.0699	3.5	Yes	Yes	1	9	9
28	R:R:R137	R:R:S142	14.6898	6.59	Yes	No	0	9	9
29	R:R:F61	R:R:S126	25.8302	5.28	Yes	No	1	8	8
30	R:R:F133	R:R:S126	25.093	7.93	Yes	No	1	7	8
31	R:R:C146	R:R:N67	39.2184	12.6	No	No	0	7	9
32	R:R:N67	R:R:W150	39.463	5.65	No	Yes	0	9	9
33	R:R:F75	R:R:Y109	42.6502	5.16	Yes	Yes	3	6	8
34	R:R:K102	R:R:Y106	22.7116	3.58	Yes	No	0	3	3
35	R:R:W241	R:R:Y106	23.8729	27.97	No	No	0	4	3
36	R:R:W241	R:R:Y109	22.1635	3.86	No	Yes	3	4	8
37	R:R:L237	R:R:S261	21.0282	4.5	Yes	No	0	5	5
38	R:R:S261	R:R:Y240	17.2408	3.82	No	Yes	0	5	3
39	R:R:E99	R:R:K166	13.7437	10.8	Yes	Yes	0	5	3
40	R:R:E99	R:R:K102	15.9261	5.4	Yes	Yes	4	5	3
41	R:R:F107	R:R:N157	19.5276	12.08	No	No	0	5	7
42	R:R:N157	R:R:T110	19.57	4.39	No	Yes	0	7	6
43	R:R:I186	R:R:T110	33.118	3.04	No	Yes	5	7	6
44	R:R:I186	R:R:S238	37.4274	4.64	No	Yes	0	7	7
45	R:R:S238	R:R:Y109	49.2595	3.82	Yes	Yes	0	7	8
46	R:R:L113	R:R:Y109	28.9554	14.07	No	Yes	0	8	8
47	R:R:C153	R:R:T110	20.1409	5.07	No	Yes	0	8	6
48	R:R:C153	R:R:V111	19.906	5.12	No	No	0	8	7
49	R:R:L113	R:R:S234	28.8282	4.5	No	No	0	8	7
50	R:R:F230	R:R:M194	37.3328	9.95	No	Yes	0	9	8
51	R:R:F230	R:R:T191	42.4512	3.89	No	Yes	0	9	5
52	R:R:M187	R:R:T191	49.1844	3.01	No	Yes	0	7	5
53	R:R:M187	R:R:S238	52.5119	3.07	No	Yes	0	7	7
54	R:R:M194	R:R:S120	21.5078	7.67	Yes	No	6	8	9
55	R:R:S120	R:R:S197	19.8473	1.63	No	No	0	9	8
56	R:R:C124	R:R:S197	16.2719	3.44	No	No	0	8	8
57	R:R:C124	R:R:L128	12.6705	3.17	No	No	0	8	6
58	R:R:S126	R:R:V127	48.2254	3.23	No	No	0	8	8
59	R:R:L201	R:R:V127	45.4981	4.47	No	No	0	8	8
60	R:R:R137	R:R:W132	11.2449	10	Yes	No	0	9	6
61	R:R:L141	R:R:R137	13.8644	3.64	No	Yes	0	5	9
62	R:R:F242	R:R:M180	12.7422	3.73	No	No	0	5	3
63	R:R:A183	R:R:F242	19.6581	2.77	No	No	0	5	5
64	R:R:A183	R:R:S238	21.436	1.71	No	Yes	0	5	7
65	R:R:F202	R:R:F220	10.9676	17.15	No	Yes	0	5	5
66	R:R:F220	R:R:P216	24.8907	2.89	Yes	No	0	5	7
67	R:R:P216	R:R:V205	32.8929	3.53	No	No	0	7	6
68	R:R:L201	R:R:V205	38.0733	1.49	No	No	0	8	6
69	R:R:S234	R:R:S268	28.7532	6.52	No	Yes	0	7	9
70	R:R:N272	R:R:S268	29.5753	4.47	Yes	Yes	0	9	9
71	R:R:L244	R:R:Y240	13.6883	12.89	No	Yes	0	3	3
72	R:R:L244	R:R:Q254	12.1615	3.99	No	No	0	3	2
73	R:R:P251	R:R:Q254	10.886	4.74	No	No	0	2	2
74	R:R:L237	R:R:Y109	14.1874	9.38	Yes	Yes	3	5	8
75	R:R:F107	R:R:W150	19.5081	5.01	No	Yes	0	5	9
76	R:R:V111	R:R:W150	19.893	15.94	No	Yes	0	7	9
77	R:R:C146	R:R:Y64	38.181	4.03	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7Y15_nogp

PDB Summary
PDB	7Y15_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	243
Number of Links	266
Number of Hubs	33
Number of Links mediated by Hubs	118
Number of Communities	10
Number of Nodes involved in Communities	39
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	56689
Length Of Smallest Path	3
Average Path Length	16.2936
Length of Longest Path	31
Minimum Path Strength	1.3
Average Path Strength	6.18761
Maximum Path Strength	16.83
Minimum Path Correlation	0.7
Average Path Correlation	0.920932
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	40.0802
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.664
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • myelin sheath • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • negative regulation of blood pressure • renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure • circulatory system process • angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of systemic arterial blood pressure • regulation of biological quality • blood vessel diameter maintenance • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • regulation of tube diameter • maintenance of blood vessel diameter homeostasis by renin-angiotensin • renal system process • regulation of blood pressure • regulation of tube size • regulation of systemic arterial blood pressure • endocrine process • vascular process in circulatory system • vasodilation • regulation of anatomical structure size • periplasmic space
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS7
Sequence	>7Y15_nogp_Chain_R T V H T A Y L V L S S L A M F T C L C G M A G N S M V I W L L G F R M H R N P F C I Y I L N L A A A D L L F L F S M A S T L S L E T Q P L V N T T D K V H E L M K R L M Y F A Y T V G L S L L T A I S T Q R C L S V L F P I W F K C H R P R H L S A W V C G L L W T L C L L M N G L T S S F C S K F L K F N E D R C F R V D M V Q A A L I M G V L T P V M T L S S L T L F V W V R R S S Q Q W R R Q P T R L F V V V L A S V L V F L I C S L P L S I Y W F V L Y W L S L P P E M Q V L C F S L S R L S S S V S S S A N P V I Y F L V G S R R S H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9DQJ	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2024-12-11	10.1016/j.celrep.2024.114942
	9DQJ (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-3945	-		2.9	2024-12-11	10.1016/j.celrep.2024.114942
	9DQH	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.92	2024-12-11	10.1016/j.celrep.2024.114942
	9DQH (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	EP-2825	-		2.92	2024-12-11	10.1016/j.celrep.2024.114942
	7Y14	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	-	3.2	2022-07-20	10.1038/s42003-022-03668-3
	7Y13	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	-	3.1	2022-07-20	10.1038/s42003-022-03668-3
	7Y15	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-07-20	10.1038/s42003-022-03668-3
	7Y15 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-		2.9	2022-07-20	10.1038/s42003-022-03668-3
	7Y12	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	Gi1/β1/γ2	3.1	2022-07-20	10.1038/s42003-022-03668-3
	7Y12 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-		3.1	2022-07-20	10.1038/s42003-022-03668-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y15_nogp.zip

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