Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x35 4.1625406
21x39 4.506507
31x56 5.585107
41x57 7.444146
51x60 6.04254105
6I1.W83 8.565146
72x37 4.315487
82x39 5.848587
92x42 4.85507
102x53 8.29407
112x57 3.9825407
122x63 8.335625
132x64 6.635625
14E1x50 7.37833628
15E1x52 4.1275427
163x28 5.08424
173x29 7.21333625
183x42 6.6925157
193x43 4.4875408
203x46 5.4025488
213x49 9.285488
223x50 9.3825489
233x51 7.69754207
24I2x51 4.4625405
254x50 7.414159
26E2.R195 10.84521
27E2.T201 9.35423
28E2x50 9.2025429
29E2x51 8.718524
30E2x52 8.98526
31E2.T205 9.035425
325x33 3.73404
335x36 7.774524
345x39 9.57405
355x58 6.931676129
366x31 7.026176
376x48 7.7508
386x49 5.034215
396x52 9.1875408
406x54 2.6225405
416x55 5.526526
426x62 8.5875405
436x63 4.1475423
447x34 7.40333624
457x35 8.93525
467x38 6.405625
477x53 6.26489
487x54 3.8365106
49G.HN.11 2.11402
50G.HN.43 5.3625408
51G.hns1.02 5.2425403
52G.S1.06 5.9475458
53G.H1.01 4.355459
54G.H1.04 10.8675457
55G.H1.07 3.7675409
56G.H1.12 5.8025408
57G.S2.04 7.938556
58G.S3.03 4.505407
59G.S3.04 9.515407
60G.S3.05 5.9125457
61G.S3.07 5.576559
62G.H2.05 9.6275417
63G.H2.06 7.03167619
64G.H2.07 6.28857719
65G.h2s4.01 7.634519
66G.S4.03 5.304558
67G.S4.04 7.3475409
68G.s4h3.04 8.192508
69G.H3.13 5.8954255
70G.H3.15 3.45618
71G.H3.17 7.404515
72G.H3.18 4.676519
73G.S5.05 6.854559
74G.s5hg.01 3.86254239
75G.hgh4.05 6.665406
76G.h4s6.13 3.99754257
77G.S6.02 8.055228
78G.S6.05 7.0254265
79G.H5.03 7.336558
80G.H5.15 3.456168
81G.H5.17 6.564175
82G.H5.23 8.24684
83b.1x3 5.76754271
84b.lhb1x11 4.3975444
85b.b1x3 4.8475447
86b.l1x3 6.265669
87b.l1x6 7.685419
88b.b2x1 9.52518
89b.b2x5 9.5275407
90b.b3x3 4.795408
91b.l3x2 7.72409
92b.b4x5 4.9025187
93b.b4x6 8.84769
94b.l4x1 4.6175445
95b.l4x2 9.0525444
96b.b5x3 6.855669
97b.b5x5 5.445185
98b.l5x1 4.52254138
99b.l5x5 7.73143719
100b.b6x5 4.7275406
101b.b7x1 7.9475494
102b.b8x3 5.3175496
103b.b8x4 6.4685136
104b.l9x3 10.01254119
105b.l9x6 6.65571718
106b.b10x5 5.285409
107b.l10x1 4.23754313
108b.b11x1 6.59254315
109b.b11x4 5.05754119
110b.b11x5 5.5975476
111b.l11x2 6.2554119
112b.b12x3 4.4775478
113b.b12x6 10.6445118
114b.l12x1 4.6475406
115b.b13x7 7.784577
116b.l13x3 7.9725479
117b.l13x7 5.3579
118b.b15x3 3.345479
119b.l15x1 7.215417
120b.l15x2 7.5575409
121b.b16x4 6.31167676
122b.b16x6 9.222578
123b.b17x5 5.906537
124b.b17x7 9.2275438
125b.l17x3 8.36857739
126b.l17x6 10.715419
127b.b18x3 5.0975438
128b.l18x2 5.66754197
129b.b19x2 9.7725436
130b.b19x4 6.2775438
131b.l19x1 5.45419
132b.l19x2 8.33439
133b.b20x2 5.614536
134b.b20x4 8.896538
135b.b20x6 7.942536
136b.l20x2 6.84409
137b.b21x2 5.1654286
138b.b21x7 5.178505
139b.l21x5 4.3425414
140b.l21x7 3.7425415
141b.b22x4 3.75405
142b.l22x5 8.264339
143b.b23x1 3.975405
144b.b23x2 6.055406
145b.b23x6 6.964517
146b.l23x1 9.015416
147b.l23x2 5.7375418
148b.b24x6 7.35408
149b.l24x3 5.145405
150b.l25x3 12.558549
151b.l25x6 13.1725418
152b.b27x5 7.7975449
153b.l27x1 10.7475819
154b.l27x2 10.15449
155b.b28x4 10.7975446
156b.b28x6 9.096549
157b.b28x7 6.755449
158g.ctx3 5.516509
159g.ctx4 5.0225407
160g.ctx6 3.0675406
161g.ctx14 6.7325449
162g.ctx15 7.5475449
163g.ctx16 6.36889948
164Lig 8.1751220
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
17x38 Lig 12.56653.02YesYes250
23x43 6x45 44.60483.65YesNo089
36x45 6x48 46.18888.25NoYes098
46x48 6x52 44.37474.36YesYes088
56x51 6x52 37.244510.18NoYes078
66x51 7x34 36.88524.13NoYes074
77x54 8x50 11.9354.29YesNo068
82x43 8x50 13.80923.73NoNo088
91x57 2x43 14.43333.73YesNo068
101x57 I1.W83 15.03838.02YesYes1466
112x40 I1.W83 20.036112.36NoYes076
122x37 2x40 20.65713.26YesNo077
132x37 2x39 15.14463.1YesYes877
143x43 7x53 50.02754.69YesYes089
153x50 7x53 51.54149.26YesYes899
163x50 G.H5.25 74.668914.58YesNo098
17G.H5.20 G.H5.25 74.79635.54NoNo088
186x31 G.H5.20 74.40994.86YesNo1768
196x31 G.H5.13 75.455.96YesNo068
20G.H5.13 G.S6.02 75.804911.49NoYes088
21G.H5.10 G.S6.02 76.71375.34NoYes078
22G.H5.10 G.S5.03 76.83293.25NoNo078
23G.S4.03 G.S5.03 77.49085.83YesNo088
24G.S4.03 G.S5.05 89.5986.22YesYes589
25G.H1.04 G.S5.05 91.844512.86YesYes579
26G.H1.04 G.S4.05 93.09749.74YesNo076
27G.S4.05 G.s1h1.05 93.64043NoNo069
28G.S4.07 G.s1h1.05 93.92023.42NoNo089
29G.S4.07 G.s5hg.01 94.47146.42NoYes089
30G.s4h3.02 G.s5hg.01 94.65793.06NoYes2399
31G.HG.07 G.s4h3.02 94.92217.65NoNo099
32G.HG.07 G.s4h3.04 94.587319.11NoYes098
33G.HG.15 G.s4h3.04 97.70055.86NoYes078
34G.HG.15 G.hgh4.02 98.77624.87NoNo078
35G.hgh4.02 G.s4h3.15 98.92493.62NoNo089
36G.H3.03 G.s4h3.15 98.99873.94NoNo049
37G.H3.03 G.H3.06 99.07238.1NoNo046
38G.H3.06 G.h4s6.01 99.14555.64NoNo064
39G.H3.09 G.h4s6.01 99.00943.65NoNo094
40G.H3.09 G.S4.04 1008.57NoYes099
41G.H3.12 G.S4.04 38.47913.77NoYes089
42G.H3.12 G.H3.15 33.70173.63NoYes188
43G.H3.15 G.H3.17 34.09533.86YesYes185
44G.H3.17 b.l25x6 20.43566YesYes158
45b.l23x1 b.l25x6 36.281923.82YesYes168
46b.l21x7 b.l23x1 37.07083.11YesYes156
47b.l21x7 b.l23x2 26.3414.67YesYes158
48b.b24x2 b.l23x2 16.18758.08NoYes058
49b.b24x2 b.b25x6 15.80844.43NoNo053
50b.b25x5 b.b25x6 15.63111.84NoNo043
51b.b24x5 b.b25x5 15.47821.84NoNo054
52b.b23x1 b.b24x5 15.46344.47YesNo055
53b.b23x1 g.ctx5 10.54974.15YesNo059
543x50 G.H5.23 15.75966.17YesYes894
55G.H3.17 b.l27x1 12.92495.62YesYes159
56b.b26x1 b.l27x1 24.33553.71NoYes099
57b.b26x1 b.b26x2 25.26983.44NoNo097
58b.b26x2 b.l1x7 23.59424.91NoNo079
59b.l1x3 b.l1x7 19.3977.95YesNo699
60b.b4x6 b.l1x3 15.07746.35YesYes699
61G.S1.07 G.S4.04 13.683913.4NoYes099
62G.S1.05 G.S1.07 13.63789.69NoNo099
63G.S1.05 G.h2s4.01 14.097910.96NoYes099
64G.S2.03 G.S3.04 18.400613.96NoYes097
65G.S3.04 b.l5x4 29.51313.95YesNo078
66b.b4x1 b.l5x4 28.73813.71NoNo088
67b.b4x1 b.l5x1 27.97913.42NoYes088
68b.b8x4 b.l5x1 12.00837.03YesYes1368
69G.h2s4.01 b.l5x5 15.578413.03YesYes199
70G.S2.03 b.l5x5 11.42948.72NoYes199
71G.S1.03 b.l5x5 11.60739.28NoYes099
72G.S1.03 G.S3.04 15.30226.19NoYes097
73G.S1.04 G.S3.03 10.43833.65NoYes077
74G.S1.04 G.S3.05 10.72917.07NoYes077
75G.H3.08 G.S4.04 48.81293.65NoYes089
76G.H2.04 G.H3.08 48.77864.86NoNo098
77G.H2.04 G.H2.07 48.80627NoYes099
78G.H2.07 b.l9x6 64.97868.68YesYes198
79G.H2.06 b.l9x6 76.33813.58YesYes198
80b.b14x1 b.l9x6 11.59988.38NoYes188
81G.H2.06 b.l19x1 78.93924.15YesYes199
82b.b2x1 b.l27x1 29.076617.36YesYes189
83b.b6x1 b.l9x6 33.74495.99NoYes098
84G.H2.10 b.b6x1 29.05964.86NoNo079
85G.H2.10 b.b2x1 28.34245.38NoYes178
86b.l17x5 b.l19x1 79.31872.94NoYes069
87b.l17x5 b.l19x2 79.16645.89NoYes069
88b.l17x4 b.l19x2 22.817314.29NoYes039
89b.l17x3 b.l17x4 22.6233.69YesNo093
90b.b19x4 b.l17x3 35.548.21YesYes389
91b.b19x4 b.b20x6 28.57267.78YesYes386
92b.b17x7 b.b20x6 63.719111.79YesYes386
93b.b17x5 b.b17x7 60.83257.03YesYes378
94b.b17x5 b.b21x1 49.0047.83YesNo377
95b.1x19 b.b21x1 46.03899.53NoNo367
96b.1x15 b.1x19 44.56327.52NoNo076
97b.1x14 b.1x15 41.6015.49NoNo047
98b.1x11 b.1x14 38.63775.32NoNo084
99b.1x11 g.h1x12 28.2562.82NoNo086
100g.h1x12 g.h1x8 26.77163.04NoNo067
101b.1x4 g.h1x8 23.8028.94NoNo087
102b.b19x6 b.l19x2 22.81697.36NoYes399
103b.b19x6 b.l17x3 22.622313.95NoYes399
104b.b20x2 b.l19x2 33.38055.78YesYes369
105b.b20x2 b.l17x3 22.62569.58YesYes369
106b.b20x4 b.l17x3 30.462412.41YesYes389
107b.b20x4 b.b20x6 38.10517.48YesYes386
108b.b20x2 b.b21x6 10.3614.71YesNo361
109b.b20x4 b.b21x6 10.16736.47YesNo381
110b.1x4 g.h1x4 13.39841.58NoNo085
111b.1x1 g.h1x4 11.91091.58NoNo045
112b.l21x5 b.l21x7 10.59593.27YesYes145
113b.b23x6 b.l21x5 10.20443.63YesYes174
114b.b23x6 b.b24x6 18.939911.58YesYes078
115b.b21x7 b.b24x6 16.65357.72YesYes058
116b.b21x7 b.b23x2 12.94774.69YesYes056
117b.b22x5 b.b23x2 11.539313.4NoYes076
118b.b23x6 b.l23x2 10.37544.6YesYes178
119b.b3x2 b.b4x6 11.03743.42NoYes059
120b.b2x5 b.b3x2 10.854315.94YesNo075
121b.b7x4 b.l5x1 14.48093.17NoYes1388
122b.b4x3 b.b7x4 13.7763.17NoNo078
123b.b3x3 b.b4x3 13.00454.47YesNo087
124b.b6x1 b.l7x1 11.56793.49NoNo099
125b.b7x5 b.l7x1 11.33432.11NoNo099
126b.b7x5 b.l9x7 11.10035.13NoNo097
127b.b10x1 b.b14x1 14.83413.07NoNo098
128b.b10x1 b.b11x5 14.58263.26NoYes096
1297x34 7x38 30.353514.4YesYes245
130G.S3.05 G.S4.03 11.37955.78YesYes578
131b.l25x6 b.l27x1 16.206918.99YesYes189
132G.H2.07 G.h2s4.01 10.64765.01YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x322x644.130NoYes3521
1x32E1.T1153.890NoNo3422
1x327x3113.410NoNo3421
1x351x395.860YesYes6722
1x352x643.520YesYes6521
1x357x353.990YesYes6522
1x397x383.090YesYes7521
2x603x299.720NoYes7521
2x632x6414.892YesYes5511
2x63E1.T1154.992YesNo5412
2x63E1x5011.582YesYes5812
2x633x293.092YesYes5511
2x63E2x506.722YesYes5912
2x63Lig8.742YesYes5010
2x643x293.092YesYes5511
2x647x386.172YesYes5511
2x64Lig8.012YesYes5010
E1.T115E2.T2014.710NoYes4321
E1x50E2x5013.062YesYes8922
3x29E2x509.752YesYes5912
3x29E2x5213.12YesYes5611
3x29Lig4.532YesYes5010
3x33E2x523.780NoYes5621
E2.K196E2.R19517.330NoYes2121
E2.N197E2.R1957.230NoYes4121
E2.R195E2.T2019.062YesYes1311
E2.R195E2x519.262YesYes1411
E2.R195Lig11.322YesYes1010
E2.T201E2x5119.972YesYes3411
E2.T201Lig3.662YesYes3010
E2x51Lig10.192YesYes4010
E2.T205E2x5210.122YesYes5611
7x38E2x523.572YesYes5611
E2x52Lig14.332YesYes6010
E2.T205E2.T2064.712YesNo5512
5x36E2.T20511.242YesYes4521
E2.T205Lig10.072YesYes5010
5x33E2.T2064.420YesNo4522
5x36E2.T20611.242YesNo4522
5x336x623.640YesYes4521
6x586x629.640NoYes4521
6x587x348.140NoYes4422
6x62E3.Q29110.510YesNo5212
6x62Lig10.560YesYes5010
7x317x3519.160NoYes4512
7x31Lig10.920NoYes4010
7x347x355.642YesYes4522
7x347x3814.42YesYes4521
7x357x388.182YesYes5521
7x38Lig3.022YesYes5010
E2.G193E2x512.90NoYes2421
LigNT.T452.752YesNo0301
E2.S207E2x511.270NoYes5421

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
90.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
80.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
80.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
64.29Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
53.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
52.94Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
50.00Single3OE9IT1t3OE9-CXCR4-IT1t
50.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
50.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
50.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
47.37Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
47.37Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
47.06Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
47.06Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
45.45Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
44.44Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
44.44Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
43.75Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
43.75Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
42.86Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
42.86Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
42.86Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
42.86Consensushca_onOrthosteric Ligandhca2_on
42.86Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
42.11Single4XT1Fractalkine4XT1-US28-Fractalkine
42.11Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
41.67Single3OE6IT1t3OE6-CXCR4-IT1t
41.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
41.18Single6OS2TRV0266OS2-AT1-TRV026
41.18Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
41.18Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
41.18Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
41.18Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.18Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
41.18Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
40.91Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
40.91Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
40.91Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
40.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
40.00Single6D27CAY104716D27-DP2-CAY10471
40.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
40.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
40.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
40.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
40.00Single8K5DGSK2560738K5D-HCA2-GSK256073
40.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
40.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
40.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
40.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
40.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
40.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
40.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
40.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
40.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
40.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
40.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
39.13Single4XT3Fractalkine4XT3-US28-Fractalkine
38.89Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
38.89Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.89Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
38.89Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89Consensusprostanoid_offOrthosteric Ligandep_off dp_off
38.46Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
38.46Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
38.10Single3OE0CVX153OE0-CXCR4-CVX15
38.10Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
38.10Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
37.50Single6D26Fevipiprant6D26-DP2-Fevipiprant
37.50Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
37.50Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
37.50Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
37.50Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
37.50Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
37.50Consensusdp_offOrthosteric Liganddp2_off
37.50Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
37.50Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
37.50Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
37.50Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
37.50Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
36.84Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
36.84Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
36.36Single6JODAngiotensin II6JOD-AT2-Angiotensin II
36.36Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
35.71Single3ODUIT1t3ODU-CXCR4-IT1t
35.71Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
35.71Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
35.71Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
35.71Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
35.71Single8GNGIstradefylline8GNG-A2A-Istradefylline
35.71Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
35.71Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
35.71Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
35.71Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
35.71Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
35.71Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
35.29Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
35.29Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
35.29Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
35.29Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
35.29Consensusrelaxin_onOrthosteric Ligandrxfp4_on
35.29Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
35.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
35.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
35.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
35.00Single8XWNCXCL88XWN-CXCR2-CXCL8
35.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
35.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
35.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
35.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
35.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
34.78Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
34.78Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.78Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
34.78Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
34.78Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
34.62Single6IGKEndothelin-36IGK-ETB-Endothelin-3
33.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
33.33Single4XESNeurotensin4XES-NTS1-Neurotensin
33.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
33.33Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
33.33Single6MH8ZM-2413856MH8-A2A-ZM-241385
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
33.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
33.33Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
33.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
33.33Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
33.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
33.33Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
33.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
33.33Single8IHKAcifran8IHK-HCA3-Acifran
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
33.33Single8K5CAcipimox8K5C-HCA2-Acipimox
33.33Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
33.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
33.33Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
33.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
33.33Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
33.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
33.33Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
33.33Consensusp2y_offOrthosteric Ligandp2y1_off
32.00Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.00Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
32.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.00Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
31.82Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
31.82Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
31.82Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.82Consensusangiotensin_onOrthosteric Ligandat1_on
31.82Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
31.82Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
31.82Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
31.82Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
31.58Single4BUONeurotensin4BUO-NTS1-Neurotensin
31.58Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
31.58Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
31.58Single8XVUCXCL28XVU-CXCR2-CXCL2
31.58Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
31.58Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
31.58Consensuscck_onOrthosteric Ligandccka_on cckb_on
31.58Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
31.58Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
31.25Single4QIMANTA XV4QIM-SMO-ANTA XV
31.25Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
31.25Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
31.25Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
31.25Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
31.25Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.25Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
31.25Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
31.25Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
31.25Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
31.25Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
31.25Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
31.25Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
30.77Single4XNWMRS25004XNW-P2Y1-MRS2500
30.77Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
30.77Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
30.43Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.43Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
30.43Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
30.43Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
30.43Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
30.43Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.43Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.43Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.43Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
30.43Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
30.43Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
30.43Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
30.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
30.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
30.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
30.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
30.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
30.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
29.63Single5GLHEndothelin-15GLH-ETB-Endothelin-1
29.63Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
29.63Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
29.63Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
29.63Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
29.41Single4JKVTaladegib4JKV-SMO-Taladegib
29.41Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
29.41Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
29.41Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
29.41Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
29.17Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
29.17Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
29.17Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
29.17Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
29.17Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
29.17Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
29.17Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
29.17Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.17Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single7F8XNN90567F8X-CCKA-NN9056
28.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
28.57Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
28.57Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
28.57Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
28.57Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
28.57Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
28.57Single8K5BNiacin8K5B-HCA2-Niacin
28.57Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
28.57Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
28.57Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
28.57Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
28.57Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Single7SK3CXCL127SK3-ACKR3-CXCL12
28.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
28.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
28.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
28.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
28.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
28.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
27.78Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
27.78Single5V56TC1145V56-SMO-TC114
27.78Single5V57TC1145V57-SMO-TC114
27.78Single6OS1TRV0266OS1-AT1-TRV026
27.78Single7B6WCyclazosin7B6W-α1b-Cyclazosin
27.78Single7F1TMIP-1a7F1T-CCR5-MIP-1a
27.78Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
27.78Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
27.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
27.78Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
27.78Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
27.78Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
27.78Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
27.78Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
27.78Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
27.78Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
27.78Consensusneurotensin_onOrthosteric Ligandnts1_on
27.78Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
27.59Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
27.27Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
27.27Single7SK5CXCL127SK5-ACKR3-CXCL12
27.27Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
27.27Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
27.27Single7XNACYN1548067XNA-SST2-CYN154806
27.27Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
27.27Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
27.27Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
27.27Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
26.92Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
26.92Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
26.67Single3PWHZM-2413853PWH-A2A-ZM-241385
26.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
26.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
26.67Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
26.67Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
26.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
26.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
26.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
26.67Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
26.67Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
26.67Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
26.67Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.67Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
26.67Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.67Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.32Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
26.32Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
26.32Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
26.32Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
26.32Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
26.32Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.32Single7K15MKD0467K15-BLT1-MKD046-Na
26.32Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.32Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
26.32Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.32Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
26.32Single8JWY2-1188JWY-A2A-2-118
26.32Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
26.32Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.32Single8XWACXCL18XWA-CXCR2-CXCL1
26.32Single8XWMCXCL68XWM-CXCR2-CXCL6
26.32Single8XWSCXCL58XWS-CXCR2-CXCL5
26.32Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
26.32Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.32Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.32Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.32Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
26.32Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
26.32Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
26.32Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
26.32Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
26.32Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.32Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
26.09Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
26.09Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
26.09Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
26.09Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.09Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.09Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
26.09Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
26.09Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
26.09Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
25.93Single6IGLIRL16206IGL-ETB-IRL1620
25.93Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
25.93Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.93Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.93Consensusbradykinin_onOrthosteric Ligandbk2_on
25.93Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
25.93Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Single3REYXAC3REY-A2A-XAC
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
25.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
25.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
25.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
25.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
25.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
25.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
25.00Single7AROLUF58337ARO-A2A-LUF5833-Na
25.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
25.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
25.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
25.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
25.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
25.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
25.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
25.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
25.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
25.00Single8PWNTheophylline8PWN-A2A-Theophylline
25.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
25.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
25.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XWFCXCL38XWF-CXCR2-CXCL3
25.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
25.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
25.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
25.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
25.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
25.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00Consensusbombesin_onOrthosteric Ligandbb2_on
25.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
25.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
24.14Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
24.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
24.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
24.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
24.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
24.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
23.81Single6KNMJN241-96KNM-Apelin-JN241-9
23.81Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
23.81Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
23.81Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
23.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
23.81Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
23.81Single8QJ2pN1628QJ2-MC4-pN162-Gs
23.81Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
23.81Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
23.81Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
23.81Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
23.81Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
23.81Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
23.81Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
23.53Single3EMLZM-2413853EML-A2A-ZM-241385
23.53Single4YAYZD-71554YAY-AT1-ZD-7155
23.53Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
23.53Single5T04Neurotensin5T04-NTS1-Neurotensin
23.53Single5TGZAM65385TGZ-CB1-AM6538
23.53Single5UIGCmpd-15UIG-A2A-Cmpd-1
23.53Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
23.53Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
23.53Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
23.53Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
23.53Single6S0LZM-2413856S0L-A2A-ZM-241385
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.53Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
23.53Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
23.53Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
23.53Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.53Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
23.53Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
23.53Single7V3ZCP559407V3Z-CB1-CP55940
23.53Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
23.53Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
23.53Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
23.53Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.53Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
23.53Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.53Single8CU6LJ-45178CU6-A2A-LJ-4517
23.53Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
23.53Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
23.53Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
23.53Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
23.08Single3OE8IT1t3OE8-CXCR4-IT1t
23.08Single6FJ3PTH6FJ3-PTH1-PTH
23.08Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.08Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.08Single8A2OTheophylline8A2O-A2A-Theophylline-Na
23.08Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
23.08Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
23.08Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.08Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.73Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
22.73Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
22.73Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
22.73Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
22.73Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
22.73Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
22.73Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
22.73Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
22.73Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
22.73Single8WDTphotoNECA8WDT-A2A-photoNECA
22.73Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
22.73Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.73Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
22.73Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.73Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.73Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
22.73Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
22.73Consensuslpl_onOrthosteric Ligands1p_on lpa_on
22.73Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
22.73Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
22.73Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
22.73Consensussomatostatin_offOrthosteric Ligandsst2_off
22.58Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.22Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.22Single5N2SPSB365N2S-A1-PSB36
22.22Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
22.22Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
22.22Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
22.22Single6S0QZM-2413856S0Q-A2A-ZM-241385
22.22Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
22.22Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
22.22Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
22.22Single7C4SS1P7C4S-S1P3-S1P
22.22Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
22.22Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
22.22Single7W41PD1762527W41-BB2-PD176252
22.22Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
22.22Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
22.22Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.22Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
22.22Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
22.22Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.22Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
22.22Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
22.22Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
22.22Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
22.22Consensusblt_offOrthosteric Ligandblt1_off
22.22Consensusbombesin_offOrthosteric Ligandbb2_off
22.22Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.22Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.22Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
22.22Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.22Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
22.22Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
22.22Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
22.22Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
21.74Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
21.74Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
21.74Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
21.74Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.74Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
21.74Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
21.74Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
21.74Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
21.74Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
21.74Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
21.74Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
21.74Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.74Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.74Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.74Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
21.74Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
21.43Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
21.43Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
21.43Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
21.43Single6ME5Agomelatine6ME5-MT1-Agomelatine
21.43Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
21.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
21.43Single8IY6Endothelin-18IY6-ETB-Endothelin-1
21.43Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
21.43Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.43Consensusendothelin_onOrthosteric Ligandetb_on eta_on
21.43Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
21.21Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.21Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.05Single4BV0Neurotensin4BV0-NTS1-Neurotensin
21.05Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
21.05Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.05Single5XR8AM8415XR8-CB1-AM841
21.05Single5XRAAM115425XRA-CB1-AM11542
21.05Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
21.05Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
21.05Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
21.05Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
21.05Single7FEECP559407FEE-CB1-CP55940-ZCZ011
21.05Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
21.05Single7PX4PSB-21137PX4-A2A-PSB-2113
21.05Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
21.05Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.05Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
21.05Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
21.05Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
21.05Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.05Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
21.05Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
21.05Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
21.05Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
21.05Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensusa2_onOrthosteric Liganda2b_on
21.05Consensusa2_on_gpOrthosteric Liganda2b_on_gp
21.05Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.05Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.05Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
21.05Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
21.05Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
21.05Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
21.05Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
21.05Consensuslpa_onOrthosteric Ligandlpa1_on
21.05Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
20.83Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.83Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.83Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
20.83Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
20.83Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
20.83Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.83Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
20.83Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
20.83Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
20.69Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
20.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
20.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
20.00Single5L7IVismodegib5L7I-SMO-Vismodegib
20.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
20.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
20.00Single6KQICP559406KQI-CB1-CP55940-Org27569
20.00Single6LI0C176LI0-GPR52-C17
20.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
20.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
20.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
20.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
20.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
20.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
20.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
20.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
20.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
20.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
20.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
20.00Single8JJLOlodaterol8JJL-β2-Olodaterol
20.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
20.00Single8JWZAB9288JWZ-A2A-AB928-Na
20.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
20.00Single8XQJJN2418XQJ-Apelin-JN241
20.00Single8XYIVUF106618XYI-CXCR3-VUF10661
20.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
20.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
20.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
20.00Single9B9Y7DY9B9Y-CB1-7DY
20.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
20.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
20.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
20.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
20.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
20.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
20.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
20.00Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
20.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
20.00Consensuslpa_offOrthosteric Ligandlpa1_off
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
20.00Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
20.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
20.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
20.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
20.00Consensusorexin_onOrthosteric Ligandox2_on
20.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
19.35Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
19.23Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
19.23Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
19.23Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
19.23Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
19.23Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
19.23Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8ZRTET-18ZRT-ETB-ET-1
19.23Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
19.23Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.23Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.23Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
19.23Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
19.05Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
19.05Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
19.05Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
19.05Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
19.05Single6IBLArformoterol6IBL-β1-Arformoterol
19.05Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
19.05Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
19.05Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
19.05Single7EZCUKA7EZC-A2A-UKA
19.05Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
19.05Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
19.05Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
19.05Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
19.05Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
19.05Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
19.05Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
19.05Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
19.05Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
19.05Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.05Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
19.05Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.05Consensuschemerin_onOrthosteric Ligandcml1_on
19.05Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
18.75Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
18.75Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
18.75Single4QINSAG1.54QIN-SMO-SAG1.5
18.75Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
18.75Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
18.75Single5U09Taranabant5U09-CB1-Taranabant
18.75Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
18.75Single6ME9Ramelteon6ME9-MT2-Ramelteon
18.75Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
18.75Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
18.75Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
18.75Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
18.75Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
18.75Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
18.75Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
18.75Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
18.75Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
18.75Single7XRRLemborexant7XRR-OX2-Lemborexant
18.75Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
18.75Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
18.75Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
18.75Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
18.75Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
18.75Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
18.75Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
18.75Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
18.75Single9BA0A1AKN9BA0-CB1-A1AKN
18.75Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
18.75Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
18.75Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
18.75Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
18.75Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
18.52Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
18.52Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
18.52Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.52Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
18.52Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
18.18Single4UG2CGS216804UG2-A2A-CGS21680
18.18Single5WF6UK-4320975WF6-A2A-UK-432097
18.18Single5ZTYAM102575ZTY-CB2-AM10257
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
18.18Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
18.18Single7XN9L-054,5227XN9-SST2-L-054,522
18.18Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
18.18Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
18.18Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
18.18Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
18.18Single8XQJJN2418XQJ-Apelin-JN241
18.18Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
18.18Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
18.18Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
18.18Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
18.18Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
18.18Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.18Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.86Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
17.86Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
17.86Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
17.86Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
17.86Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.65Single2YDOAdenosine2YDO-A2A-Adenosine
17.65Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
17.65Single5IU7Q274563465IU7-A2A-Q27456346-Na
17.65Single5IUBQ274563445IUB-A2A-Q27456344-Na
17.65Single5JTBZM-2413855JTB-A2A-ZM-241385
17.65Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
17.65Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
17.65Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
17.65Single5UVIZM-2413855UVI-A2A-ZM-241385
17.65Single6AQFZM-2413856AQF-A2A-ZM-241385
17.65Single6KUXRS-799486KUX-α2a-RS-79948
17.65Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
17.65Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
17.65Single6V9SGTPL114036V9S-OX1-GTPL11403
17.65Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
17.65Single6ZG9GSK10347026ZG9-M1-GSK1034702
17.65Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
17.65Single7T32ZM-2413857T32-A2A-ZM-241385
17.65Single7UL3Famotidine7UL3-H2-Famotidine
17.65Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
17.65Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
17.65Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
17.65Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
17.65Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
17.65Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
17.65Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
17.65Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
17.65Consensusa2_offOrthosteric Liganda2a_off
17.65Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
17.65Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
17.65Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
17.65Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
17.65Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
17.65Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.39Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
17.39Single4IARErgotamine4IAR-5-HT1B-Ergotamine
17.39Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
17.39Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.39Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
17.39Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
17.39Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
17.39Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
17.39Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
17.39Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
17.39Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
17.39Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
17.39Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.39Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.39Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
17.39Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
17.39Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
17.24Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
17.24Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
17.24Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
17.24Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.24Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
17.24Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.14Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
16.67Single2Y02Carmoterol2Y02-β1-Carmoterol
16.67Single2Y04Salbutamol2Y04-β1-Salbutamol
16.67Single3QAKUK-4320973QAK-A2A-UK-432097
16.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
16.67Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
16.67Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
16.67Single4QKX35V4QKX-β2-35V
16.67Single5IU8Q274563475IU8-A2A-Q27456347-Na
16.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
16.67Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
16.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
16.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
16.67Single5UENDU1725UEN-A1-DU172
16.67Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
16.67Single6DRXLisuride6DRX-5-HT2B-Lisuride
16.67Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
16.67Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
16.67Single6TOTLemborexant6TOT-OX1-Lemborexant
16.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
16.67Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
16.67Single7PYRPSB-21157PYR-A2A-PSB-2115
16.67Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
16.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.67Single7UL4Alvimopan7UL4-μ-Alvimopan
16.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
16.67Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
16.67Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
16.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
16.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
16.67Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
16.67Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
16.67Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
16.67Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
16.67Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
16.67Single8RLNLUF58348RLN-A2A-LUF5834
16.67Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
16.67Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
16.67Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
16.67Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
16.67Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
16.67Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
16.67Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
16.67Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9B9ZA1AKO9B9Z-CB1-A1AKO
16.67Single9CHXS-Carazolol9CHX-β2-S-Carazolol
16.67Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
16.67Single9IYAONO-97105319IYA-GPR55-ONO-9710531
16.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
16.67Consensusa3_onOrthosteric Liganda3a_on
16.67Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
16.67Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
16.67Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.67Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
16.67Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
16.67Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
16.13Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
16.13Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
16.00Single5WF5UK-4320975WF5-A2A-UK-432097
16.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
16.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
16.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
16.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
16.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
16.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
16.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
16.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
16.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
16.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.79Single2Y00Dobutamine2Y00-β1-Dobutamine
15.79Single2Y03Isoprenaline2Y03-β1-Isoprenaline
15.79Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
15.79Single5N2RPSB-365N2R-A2A-PSB-36-Na
15.79Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
15.79Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
15.79Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.79Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.79Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
15.79Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.79Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
15.79Single7C61Ergotamine7C61-5-HT1B-Ergotamine
15.79Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
15.79Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
15.79Single7SINNPS-21437SIN-CaS-NPS-2143
15.79Single7SINNPS-21437SIN-CaS-NPS-2143
15.79Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.79Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
15.79Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
15.79Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
15.79Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.79Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
15.79Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
15.79Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
15.79Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
15.79Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.79Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
15.79Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
15.79Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
15.79Consensusa3_on_gpOrthosteric Liganda3a_on_gp
15.79Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.79Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.79Consensusadenosine_offOrthosteric Liganda1_off a2_off
15.79Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
15.79Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
15.79Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.79Consensusep_offOrthosteric Ligandep4_off
15.79Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.79Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.79Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
15.79Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.79Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.79Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Consensustrace-amine_onOrthosteric Ligandta1_on
15.62Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.62Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
15.38Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
15.38Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.38Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
15.38Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
15.38Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.38Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
15.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
15.38Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
15.38Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
15.38Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
15.38Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
15.38Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
15.38Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.38Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.38Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.38Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.38Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.38Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.38Consensusvasop-oxy_onOrthosteric Ligandv2_on
15.38Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
15.15Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
15.15Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
15.15Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single2YDVNECA2YDV-A2A-NECA
15.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
15.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
15.00Single4UHRCGS216804UHR-A2A-CGS21680
15.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
15.00Single5G53NECA5G53-A2A-NECA-Gs
15.00Single5TZRMK86665TZR-FFA1-MK8666
15.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
15.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
15.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
15.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
15.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
15.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.00Single6WGTLSD6WGT-5-HT2A-LSD
15.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
15.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
15.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
15.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
15.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
15.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
15.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
15.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
15.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
15.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
15.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
15.00Single8E0GBU728E0G-μ-BU72
15.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
15.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
15.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
15.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
15.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
15.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
15.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
15.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.00Single8XVLZibotentan8XVL-ETA-Zibotentan
15.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
15.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
15.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
15.00Single9BJKNAM9BJK-μ-Naloxone-NAM
15.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
15.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
15.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
15.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
15.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
15.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
15.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
15.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
15.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
14.81Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.81Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
14.81Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
14.81Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
14.81Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.81Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
14.81Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.81Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
14.29Single3RFMCaffeine3RFM-A2A-Caffeine
14.29Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
14.29Single4AMIBucindolol4AMI-β1-Bucindolol
14.29Single4LDEBI1671074LDE-β2-BI167107
14.29Single4N4WSANT-14N4W-SMO-SANT-1
14.29Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
14.29Single4PY02MeSATP4PY0-P2Y12-2MeSATP
14.29Single4RWADIPP-NH24RWA-δ-DIPP-NH2
14.29Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
14.29Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
14.29Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6MXTSalmeterol6MXT-β2-Salmeterol
14.29Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
14.29Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
14.29Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.29Single6ZG4HTL00099366ZG4-M1-HTL0009936
14.29Single7DFPSpiperone7DFP-D2-Spiperone
14.29Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
14.29Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
14.29Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
14.29Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
14.29Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.29Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
14.29Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
14.29Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
14.29Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
14.29Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
14.29Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
14.29Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
14.29Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
14.29Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
14.29Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
14.29Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
14.29Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
14.29Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
14.29Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
14.29Consensusalpha1_offOrthosteric Ligandalpha1a_off
14.29Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
14.29Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
14.29Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
14.29Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
14.29Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
14.29Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
14.29Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
14.29Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
13.79Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
13.79Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
13.79Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
13.79Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
13.79Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
13.79Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
13.79Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
13.79Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
13.79Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
13.79Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.79Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
13.79Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
13.79Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.64Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
13.64Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
13.64Single6H7LDobutamine6H7L-β1-Dobutamine
13.64Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.64Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.64Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
13.64Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
13.64Single7UM4AS26747237UM4-5-HT5A-AS2674723
13.64Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
13.64Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
13.64Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
13.64Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
13.64Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
13.64Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
13.64Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
13.64Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
13.64Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.64Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.64Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
13.64Consensusendothelin_offOrthosteric Ligandetb_off
13.64Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
13.64Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single3UZAGTPL92363UZA-A2A-GTPL9236
13.33Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
13.33Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.33Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
13.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.33Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
13.33Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
13.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
13.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.33Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
13.33Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
13.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
13.33Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
13.33Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
13.33Single8JPSCCL78JPS-ACKR1-CCL7
13.33Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
13.33Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.33Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
13.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.04Single3NY9ICI118-5513NY9-β2-ICI118-551
13.04Single5EE7MK08935EE7-Glucagon-MK0893
13.04Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
13.04Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
13.04Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
13.04Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.04Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.90Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.90Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
12.90Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.50Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
12.50Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.50Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
12.50Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
12.50Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
12.50Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
12.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
12.50Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
12.50Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
12.50Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
12.50Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.50Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8IEBA1LYA8IEB-GPR156-A1LYA
12.50Single8IEIA1LYA8IEI-GPR156-A1LYA
12.50Single8IEPA1LYA8IEP-GPR156-A1LYA
12.50Single8IEPA1LYA8IEP-GPR156-A1LYA
12.50Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
12.50Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
12.50Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
12.50Single8KIGSHU91198KIG-MC3-SHU9119-Ca
12.50Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
12.50Single8WKYPG-9348WKY-MC4-PG-934
12.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
12.50Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
12.50Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
12.50Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
12.50Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.50Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
12.50Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
12.12Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
12.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
12.12Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
12.12Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single6HLOAprepitant6HLO-NK1-Aprepitant
12.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
12.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
12.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
12.00Single8IEBA1LYA8IEB-GPR156-A1LYA
12.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.76Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
11.76Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.76Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.76Single5WS3EMPA5WS3-OX2-EMPA
11.76Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
11.76Single6DS0Ly2660976DS0-5-HT2B-Ly266097
11.76Single6ME2Ramelteon6ME2-MT1-Ramelteon
11.76Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
11.76Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.76Single6TODEMPA6TOD-OX1-EMPA-Na
11.76Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.76Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
11.76Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.76Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.76Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.76Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
11.76Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
11.76Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.76Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.76Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
11.76Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.76Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
11.76Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
11.76Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
11.76Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
11.76Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
11.76Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
11.76Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
11.76Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
11.76Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
11.76Single8IWESpermidine8IWE-TA9-Spermidine
11.76Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.76Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
11.76Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
11.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.76Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
11.76Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.76Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
11.76Single8Y0HVUF114188Y0H-CXCR3-VUF11418
11.76Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.76Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.76Consensusalpha2_offOrthosteric Ligandalpha2c_off
11.76Consensusangiotensin_offOrthosteric Ligandat1_off
11.76Consensusorexin_offOrthosteric Ligandox2_off ox1_off
11.76Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
11.76Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
11.76Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.54Single6W25SHU91196W25-MC4-SHU9119-Ca
11.54Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
11.54Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
11.54Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.54Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.43Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.11Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
11.11Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
11.11Single4ZJCSB-6740424ZJC-OX1-SB-674042
11.11Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
11.11Single6IQLL7458706IQL-D4-L745870
11.11Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.11Single6PS0S-Carazolol6PS0-β2-S-Carazolol
11.11Single6PS4ICI118-5516PS4-β2-ICI118-551
11.11Single6PS5S-Propranolol6PS5-β2-S-Propranolol
11.11Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
11.11Single6TP3Nemorexant6TP3-OX1-Nemorexant
11.11Single6TPGEMPA6TPG-OX2-EMPA
11.11Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.11Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
11.11Single6ZINSR486926ZIN-NTS1-SR48692
11.11Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
11.11Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
11.11Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
11.11Single7VV6C48/807VV6-MRGPRX2-C48/80
11.11Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
11.11Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
11.11Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
11.11Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
11.11Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
11.11Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
11.11Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
11.11Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
11.11Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
11.11Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
11.11Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
11.11Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
11.11Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
11.11Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
11.11Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
11.11Single8K2WAMG4878K2W-CXCR3-AMG487
11.11Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
11.11Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
11.11Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
11.11Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
11.11Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
11.11Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
11.11Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
11.11Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
11.11Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
11.11Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
11.11Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.53Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
10.53Single2Y01Dobutamine2Y01-β1-Dobutamine
10.53Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
10.53Single3NY8ICI118-5513NY8-β2-ICI118-551
10.53Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
10.53Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
10.53Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.53Single4GBRS-Carazolol4GBR-β2-S-Carazolol
10.53Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
10.53Single5DHGC-355DHG-NOP-C-35
10.53Single5DHHSB-6121115DHH-NOP-SB-612111
10.53Single6GPSMK08126GPS-CCR2-MK0812
10.53Single6H7MSalbutamol6H7M-β1-Salbutamol
10.53Single6IIVDaltroban6IIV-TP-Daltroban
10.53Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
10.53Single6PS1Timolol6PS1-β2-Timolol
10.53Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
10.53Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
10.53Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
10.53Single7BU7BI1671077BU7-β1-BI167107
10.53Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
10.53Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
10.53Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
10.53Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.53Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
10.53Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.53Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
10.53Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
10.53Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
10.53Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
10.53Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
10.53Single7WC7Lisuride7WC7-5-HT2A-Lisuride
10.53Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
10.53Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
10.53Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
10.53Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
10.53Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
10.53Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
10.53Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
10.53Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
10.53Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
10.53Single8JJOAlprenolol8JJO-β2-Alprenolol
10.53Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.53Single8T1WCVN4248T1W-GPR6-CVN424
10.53Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
10.53Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
10.53Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
10.53Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.53Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
10.53Consensus5ht5_onOrthosteric Ligand5ht5a_on
10.53Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.53Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
10.53Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.53Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.53Consensusblt_onOrthosteric Ligandblt1_on
10.53Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
10.53Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
10.53Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
10.53Consensusdopamine_offOrthosteric Ligandd2_off d3_off
10.53Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
10.53Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
10.53Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.53Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.53Consensusleukotriene_onOrthosteric Ligandblt_on
10.53Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
10.34Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
10.34Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.34Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.26Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
10.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
10.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
10.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
10.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
10.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
10.00Single5C1MBU725C1M-μ-BU72
10.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
10.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
10.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00Single5TVNLSD5TVN-5-HT2B-LSD
10.00Single5WIUNemonapride5WIU-D4-Nemonapride
10.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
10.00Single5WQCEMPA5WQC-OX2-EMPA
10.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
10.00Single5XPRBosentan5XPR-ETB-Bosentan
10.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
10.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.00Single6D35Cholesterol6D35-SMO-Cholesterol
10.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
10.00Single6GPXMK08126GPX-CCR2-MK0812
10.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
10.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
10.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
10.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
10.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
10.00Single6PS6Timolol6PS6-β2-Timolol
10.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
10.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
10.00Single6TP6Filorexant6TP6-OX1-Filorexant
10.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
10.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
10.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
10.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
10.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.00Single6Z4SSR486926Z4S-NTS1-SR48692
10.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
10.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
10.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
10.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
10.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
10.00Single7DTTCa7DTT-CaS-Ca-Ca
10.00Single7DTTCa7DTT-CaS-Ca-Ca
10.00Single7DTUTryptophan7DTU-CaS-Tryptophan
10.00Single7DTUTryptophan7DTU-CaS-Tryptophan
10.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
10.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
10.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
10.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
10.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
10.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
10.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
10.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
10.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
10.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
10.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
10.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
10.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
10.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
10.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
10.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
10.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
10.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
10.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
10.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
10.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
10.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
10.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
10.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
10.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
10.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
10.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
10.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
10.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
10.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
10.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
10.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
10.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
10.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
10.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
10.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
10.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
10.00Single7XW7K1-707XW7-TSH-K1-70
10.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
10.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
10.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
10.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
10.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
10.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
10.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
10.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
10.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
10.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
10.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
10.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
10.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
10.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
10.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
10.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
10.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
10.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
10.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
10.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
10.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
10.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
10.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
10.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
10.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
10.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
10.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
10.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
10.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
10.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
10.00Single8JXSPF-61428JXS-D1-PF-6142
10.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
10.00Single8S4DCMF-0198S4D-Apelin-CMF-019
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
10.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
10.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
10.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
10.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
10.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
10.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
10.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
10.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
10.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
10.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
10.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
10.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
10.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
10.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
10.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
10.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
10.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
10.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
10.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
10.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
10.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
10.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
10.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8WVXNorrin8WVX-LGR4-Norrin
10.00Single8WVYNorrin8WVY-LGR4-Norrin
10.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
10.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
10.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
10.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
10.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
10.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
10.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
10.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
10.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
10.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
10.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
10.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
10.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
10.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
10.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
10.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
10.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
10.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
10.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
10.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
10.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
10.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
10.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
10.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
10.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
10.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
10.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
10.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
10.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.68Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.68Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.68Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
9.68Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
9.52Single3P0GBI1671073P0G-β2-BI167107
9.52Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
9.52Single4DJHJDTic4DJH-κ-JDTic
9.52Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
9.52Single5D5AS-Carazolol5D5A-β2-S-Carazolol
9.52Single5D5BS-Carazolol5D5B-β2-S-Carazolol
9.52Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
9.52Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
9.52Single6J20Aprepitant6J20-NK1-Aprepitant
9.52Single6J21Aprepitant6J21-NK1-Aprepitant
9.52Single6TQ7SB-3348676TQ7-OX1-SB-334867
9.52Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.52Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
9.52Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
9.52Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
9.52Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
9.52Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
9.52Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
9.52Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
9.52Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
9.52Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
9.52Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
9.52Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.52Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.52Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
9.52Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
9.52Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
9.52Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
9.52Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
9.52Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.52Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
9.52Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
9.52Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
9.52Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
9.52Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
9.52Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
9.52Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
9.52Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
9.52Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
9.52Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.52Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.52Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.52Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
9.52Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Single3D4STimolol3D4S-β2-Timolol
9.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.09Single6A93Risperidone6A93-5-HT2A-Risperidone
9.09Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.09Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
9.09Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
9.09Single6IIURamatroban6IIU-TP-Ramatroban
9.09Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.09Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
9.09Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
9.09Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
9.09Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
9.09Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
9.09Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
9.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
9.09Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Single7YITNalfurafine7YIT-κ-Nalfurafine
9.09Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.09Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
9.09Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
9.09Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
9.09Single8JJ8Formoterol8JJ8-β2-Formoterol
9.09Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
9.09Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.09Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
9.09Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
9.09Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
9.09Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
9.09Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
9.09Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.70Single5X93K-87945X93-ETB-K-8794
8.70Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
8.70Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
8.70Single6K1QIRL25006K1Q-ETB-IRL2500
8.70Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
8.70Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
8.70Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.70Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
8.70Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
8.70Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
8.70Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
8.70Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
8.70Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
8.70Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.70Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
8.70Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
8.70Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.70Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
8.70Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
8.70Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
8.70Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
8.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
8.33Single7SK9CCX6627SK9-ACKR3-CCX662
8.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
8.33Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
8.33Single8IEIA1LYA8IEI-GPR156-A1LYA
8.33Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
8.33Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
8.33Single8X5YAstemizole8X5Y-H1-Astemizole
8.33Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.33Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7QA8Peptide7QA8-STE2-Peptide
8.00Single7QA8Peptide7QA8-STE2-Peptide
8.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.69Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
7.69Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
7.69Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
7.69Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
7.69Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
7.69Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
7.69Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
7.69Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
7.41Single6PT2KGCHM076PT2-δ-KGCHM07
7.14Single5L7DCholesterol5L7D-SMO-Cholesterol
7.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
7.14Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
7.14Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.14Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.14Single8HS2Fab0468HS2-GPR20-Fab046
7.14Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.90Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
6.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.67Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
6.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.67Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
6.67Single9CHUNoradrenaline9CHU-β2-Noradrenaline
6.67Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
6.67Consensussensory_onOrthosteric Ligandopsins_on
6.45Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.45Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.25Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
6.25Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.25Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.25Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
6.25Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
6.25Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
6.25Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.25Single7WC5Psilocin7WC5-5-HT2A-Psilocin
6.25Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
6.25Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
6.25Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
6.25Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
6.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
6.25Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.25Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
6.25Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
6.25Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.25Consensus5ht2_onOrthosteric Ligand5ht2b_on
6.25Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25Consensusgi_sensoryOrthosteric Ligandgi_opsins
6.25Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
6.25Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
6.25Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.25Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
6.25Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
5.88Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
5.88Single3PBLEticlopride3PBL-D3-Eticlopride
5.88Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.88Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.88Single6HLLCP999946HLL-NK1-CP99994
5.88Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.88Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.88Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
5.88Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
5.88Single6TP4ACT-4622066TP4-OX1-ACT-462206
5.88Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.88Single7SRQLSD7SRQ-5-HT2B-LSD
5.88Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.88Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.88Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
5.88Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
5.88Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
5.88Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.88Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
5.88Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
5.88Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
5.88Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
5.88Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
5.88Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
5.88Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
5.88Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
5.88Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
5.88Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.88Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.88Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
5.88Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
5.56Single6AKXA4R6AKX-CCR5-A4R
5.56Single6AKYMaraviroc6AKY-CCR5-Maraviroc
5.56Single6B73MP11046B73-κ-MP1104
5.56Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.56Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
5.56Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.56Single7BR3Elagolix7BR3-GnRH1-Elagolix
5.56Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
5.56Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
5.56Single7F8ULintitript7F8U-CCKA-Lintitript
5.56Single7F8YDevazepide7F8Y-CCKA-Devazepide
5.56Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
5.56Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.56Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.56Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.56Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
5.56Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
5.56Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
5.56Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
5.56Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.56Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
5.56Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
5.56Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
5.56Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
5.56Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.56Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
5.56Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.56Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
5.56Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.56Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
5.56Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.56Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
5.56Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
5.56Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.56Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.56Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
5.56Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
5.26Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.26Single4MBSMaraviroc4MBS-CCR5-Maraviroc
5.26Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
5.26Single6A94Zotepine6A94-5-HT2A-Zotepine
5.26Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.26Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.26Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
5.26Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.26Single6TPKRetosiban6TPK-OT-Retosiban
5.26Single6TPNHTL66416TPN-OX2-HTL6641
5.26Single6VI4JDTic6VI4-κ-JDTic
5.26Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
5.26Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
5.26Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
5.26Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.26Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
5.26Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
5.26Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
5.26Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
5.26Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
5.26Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
5.26Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.26Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.26Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
5.26Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.26Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
5.26Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
5.26Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
5.26Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
5.26Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
5.26Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
5.26Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
5.26Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
5.26Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
5.26Consensusalpha1_onOrthosteric Ligandalpha1a_on
5.26Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
5.26Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
5.26Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
5.26Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
5.26Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
5.26Consensusgrh_offOrthosteric Ligandgnrh1_off
5.26Consensusopsins_offOrthosteric Ligandrhodopsin_off
5.26Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
5.26Consensussensory_offOrthosteric Ligandopsins_off
5.26Consensusvasop-oxy_offOrthosteric Ligandot_off
5.00Single4DAJTiotropium4DAJ-M3-Tiotropium
5.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
5.00Single4MQSIperoxo4MQS-M2-Iperoxo
5.00Single4U14Tiotropium4U14-M3-Tiotropium
5.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
5.00Single5DSGTiotropium5DSG-M4-Tiotropium
5.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
5.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
5.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
5.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
5.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
5.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
5.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
5.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
5.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
5.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
5.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
5.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
5.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
5.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
5.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
5.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
5.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
5.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
5.00Single8JXRLSD8JXR-D1-LSD
5.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
5.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
5.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
5.00Single8X63Mepyramine8X63-H1-Mepyramine
5.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
5.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
5.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
5.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
5.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
5.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
5.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
5.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
5.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
5.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
5.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
5.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
5.00Consensuscck_offOrthosteric Ligandccka_off
5.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
5.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
5.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
5.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
5.00Consensushistamine_offOrthosteric Ligandh1_off
5.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
5.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
5.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
4.76Single5CGCHTL142425CGC-mGlu5-HTL14242
4.76Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.76Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
4.76Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
4.76Single7WC6LSD7WC6-5-HT2A-LSD
4.76Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.76Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
4.76Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
4.76Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.76Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
4.76Single8ZMFA1L108ZMF-5-HT2C-A1L10
4.76Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
4.76Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
4.76Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
4.76Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
4.76Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
4.76Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.76Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
4.76Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.76Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
4.76Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single4U15Tiotropium4U15-M3-Tiotropium
4.55Single5V54Methiothepin5V54-5-HT1B-Methiothepin
4.55Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.55Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
4.55Single6E59L-7607356E59-NK1-L-760735
4.55Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55Single6OL9Tiotropium6OL9-M5-Tiotropium
4.55Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
4.55Single7P2L4YI7P2L-mGlu5-4YI
4.55Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.55Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
4.55Single8EA0Iperoxo8EA0-M3-Iperoxo
4.55Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
4.55Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.55Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
4.55Consensus5ht1_offOrthosteric Ligand5ht1b_off
4.55Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
4.55Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
4.55Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
4.55Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.55Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.55Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
4.55Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
4.55Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
4.55Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
4.55Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
4.55Consensustachykinin_offOrthosteric Ligandnk1_off
4.35Single5CXVTiotropium5CXV-M1-Tiotropium
4.35Single6CM4Risperidone6CM4-D2-Risperidone
4.35Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
4.35Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.35Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.35Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.35Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
4.35Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
4.17Single5CGDHTL142425CGD-mGlu5-HTL14242
4.17Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.17Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.17Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8XVJMacitentan8XVJ-ETA-Macitentan
4.00Single6PT3DPI-2876PT3-δ-DPI-287
4.00Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
4.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
4.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.85Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.85Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.85Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.57Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.57Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.45Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.45Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
3.12Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
7XXH 7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
Net Summary
Imin 3
Number of Linked Nodes 872
Number of Links 1066
Number of Hubs 164
Number of Links mediated by Hubs 600
Number of Communities 33
Number of Nodes involved in Communities 253
Number of Links involved in Communities 359
Path Summary
Number Of Nodes in MetaPath 133
Number Of Links MetaPath 132
Number of Shortest Paths 1204954
Length Of Smallest Path 3
Average Path Length 34.4233
Length of Longest Path 70
Minimum Path Strength 1.355
Average Path Strength 6.6243
Maximum Path Strength 21.405
Minimum Path Correlation 0.7
Average Path Correlation 0.983202
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 44.466
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.1575
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
p2y1_off_on_gpp2y1_on_gpp2y1_off
This network is also present in following consensuses:
IdComponents
p2y_on_gpp2y1_on_gp
p2y10_on_gp
p2y12_on_gp



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Download p2y1_on_gp.zip



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