Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:L14 3.775408
2B:B:T34 5.21405
3B:B:I37 4.9275402
4B:B:V40 5.77463
5B:B:R48 11.01254117
6B:B:H54 8.39679
7B:B:Y59 8.566676148
8B:B:W63 6.85667607
9B:B:V71 4.22588
10B:B:D76 5.825479
11B:B:K78 6.3975408
12B:B:L79 4.394587
13B:B:I80 9.6475478
14B:B:W82 9.42857779
15B:B:K89 8.602579
16B:B:I93 5.705407
17B:B:L95 4.214588
18B:B:W99 9.03729
19B:B:Y105 4.655406
20B:B:Y111 7.685404
21B:B:V112 5.13488
22B:B:C114 3.812588
23B:B:Y124 6.045686
24B:B:L139 7.3675409
25B:B:H142 7.74667629
26B:B:Y145 6.33625828
27B:B:C148 5.0325446
28B:B:C149 3.8975428
29B:B:F151 5.624529
30B:B:L152 3.86403
31B:B:T159 5.272529
32B:B:S160 4.42446
33B:B:D163 8.165429
34B:B:C166 4.235448
35B:B:W169 10.62628
36B:B:Q176 7.196524
37B:B:F180 8.876547
38B:B:H183 9.428549
39B:B:V187 4.685449
40B:B:F199 9.33449
41B:B:S201 5.2625449
42B:B:C204 6.04527
43B:B:D205 7.385449
44B:B:K209 11.5725446
45B:B:L210 4.995435
46B:B:W211 10.394548
47B:B:Q220 9.62437
48B:B:F222 8.25538
49B:B:H225 8.87143739
50B:B:D228 7.885429
51B:B:I232 5.09438
52B:B:F235 7.73857766
53B:B:N237 6.972565
54B:B:F241 7.545636
55B:B:T243 6.2775438
56B:B:D247 7.67539
57B:B:R251 9.57833638
58B:B:F253 6.54571736
59B:B:D254 4.565409
60B:B:R256 8.7775409
61B:B:D258 10.036537
62B:B:M262 6.82404
63B:B:Y264 6.464505
64B:B:R283 8.25833669
65B:B:Y289 8.037157
66B:B:N293 3.5925405
67B:B:W297 6.29754158
68B:B:K301 5.4375405
69B:B:H311 9.9525169
70B:B:R314 13.6254148
71B:B:W332 11.53147149
72B:B:D333 7.8154169
73B:B:K337 9.984166
74B:B:W339 9.2625169
75B:B:N340 7.6554119
76G:G:V16 2.6425407
77G:G:R27 7.88438
78G:G:Y40 9.04466
79G:G:D48 8.062509
80G:G:P49 3.9425407
81G:G:L51 6.6475406
82G:G:V54 4.29754246
83G:G:F61 6.13758118
84R:R:H28 5.4675408
85R:R:Y29 7.665617
86R:R:F52 6.19333616
87R:R:I53 3.592503
88R:R:N63 5.21409
89R:R:K75 6.11754126
90R:R:F76 10.6565128
91R:R:Y81 11.32336129
92R:R:F83 6.31508
93R:R:N86 6.33754179
94R:R:A88 2.905409
95R:R:S90 4.534178
96R:R:D91 7.536509
97R:R:Y98 8.83125816
98R:R:N101 6.148515
99R:R:S105 5.27414
100R:R:T109 4.8475415
101R:R:Y110 7.2975415
102R:R:W117 11.465619
103R:R:F118 6.5575406
104R:R:R120 7.03875816
105R:R:E121 11.3515
106R:R:F125 9.286515
107R:R:L136 4.615407
108R:R:R142 7.8256139
109R:R:Y143 6.27408
110R:R:L160 3.83407
111R:R:W168 4.2425179
112R:R:W182 5.768515
113R:R:V194 3.445414
114R:R:L195 6.115413
115R:R:Y198 7.54714714
116R:R:H199 6.835414
117R:R:Y202 7.535617
118R:R:F210 7.69417
119R:R:Y221 4.975139
120R:R:F237 6.4425493
121R:R:K250 5.4625496
122R:R:F265 5.88667619
123R:R:W269 7.0275818
124R:R:F273 6.5225406
125R:R:D279 4.864514
126R:R:L290 4.386513
127R:R:N303 7.855419
128R:R:Y311 6.0225139
129A:A:L5 3.9775402
130A:A:F191 8.7554195
131A:A:F196 8.554107
132A:A:F199 9.238525
133A:A:D200 4.984259
134A:A:Q204 5.606529
135A:A:E207 6.52429
136A:A:K210 5.65143729
137A:A:W211 6.03667629
138A:A:F215 7.2529
139A:A:Y230 9.034558
140A:A:D231 10.685459
141A:A:M240 4.744276
142A:A:F250 7.75409
143A:A:W258 9.611676145
144A:A:F259 5.95754269
145A:A:I264 5.7125406
146A:A:F267 4.7856189
147A:A:F274 6.3275409
148A:A:K277 6.845459
149A:A:I278 4.88406
150A:A:L283 7.5825457
151A:A:C286 5.0225406
152A:A:Y287 8.76757
153A:A:Y296 5.318504
154A:A:Y302 14.885456
155A:A:F307 6.052508
156A:A:N311 6.44754298
157A:A:K317 5.4254297
158A:A:Y320 8.958597
159A:A:T324 6.7865189
160A:A:C325 3.62754307
161A:A:F336 7.445198
162A:A:D341 8.0125498
163A:A:C351 4.964134
164A:A:F354 5.688595
165L:L:?1 8.053851310
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L14 B:B:Q13 10.62785.32YesNo081
2B:B:I18 G:G:A23 13.82853.25NoNo078
3B:B:L14 G:G:A23 12.91561.58YesNo088
4B:B:I18 B:B:R22 14.28457.52NoNo076
5B:B:D258 B:B:R22 16.098510.72YesNo076
6B:B:W297 B:B:Y264 18.36065.79YesYes085
7B:B:W297 B:B:Y289 18.68576.75YesYes1587
8B:B:C271 B:B:Y289 21.45374.03NoYes1557
9B:B:C271 B:B:D290 22.29516.22NoNo056
10B:B:D290 B:B:R314 22.717422.63NoYes068
11B:B:R314 B:B:W332 68.996622.99YesYes1489
12B:B:W332 B:B:Y59 56.097310.61YesYes1498
13B:B:M101 B:B:Y59 52.22543.59NoYes098
14B:B:M101 B:B:Y145 52.11898.38NoYes098
15B:B:G162 B:B:Y145 56.18017.24NoYes298
16B:B:G162 B:B:S161 56.27553.71NoNo299
17B:B:H142 B:B:S161 55.062712.55YesNo299
18B:B:H142 B:B:T159 47.25855.48YesYes299
19B:B:C149 B:B:T159 47.913.38YesYes289
20B:B:C149 B:B:T102 47.86846.76YesNo088
21B:B:C148 B:B:T102 47.68613.38YesNo068
22B:B:C148 B:B:S160 46.91913.44YesYes466
23B:B:S160 B:B:V187 46.58564.85YesYes469
24B:B:C166 B:B:V187 43.3095.12YesYes489
25B:B:C166 B:B:F180 42.90024.19YesYes487
26B:B:F180 B:B:T178 43.19957.78YesNo074
27B:B:L168 B:B:T178 42.81084.42NoNo064
28B:B:L168 B:B:Q156 21.42096.65NoNo065
29B:B:L152 B:B:Q156 213.99YesNo035
30B:B:L152 B:B:T196 41.11094.42YesNo031
31B:B:R197 B:B:T196 40.67363.88NoNo051
32B:B:D195 B:B:R197 39.79818.34NoNo055
33B:B:A193 B:B:D195 39.35993.09NoNo045
34B:B:A193 B:B:F234 38.92134.16NoNo045
35B:B:F234 B:B:V200 37.603714.42NoNo056
36B:B:F241 B:B:V200 32.63179.18YesNo366
37B:B:F222 B:B:F241 19.51615YesYes386
38B:B:D258 B:B:F222 18.29633.58YesYes378
39B:B:L168 B:B:V213 21.19551.49NoNo064
40B:B:L152 B:B:V213 20.9851.49YesNo034
41B:B:S316 B:B:W332 31.21586.18NoYes099
42B:B:C317 B:B:S316 31.0193.44NoNo079
43B:B:C317 B:B:M61 30.63676.48NoNo076
44B:B:M61 B:B:W63 30.44995.82NoYes067
45B:B:C294 B:B:L318 99.1843.17NoNo056
46B:B:L318 B:B:S275 99.1686.01NoNo068
47B:B:S275 B:B:T274 99.15174.8NoNo088
48B:B:R314 B:B:T274 99.13513.88YesNo088
49B:B:L70 B:B:W63 17.016110.25NoYes057
50B:B:L70 B:B:W82 16.78776.83NoYes059
51B:B:D333 B:B:H311 99.49497.56YesYes1699
52B:B:H311 B:B:V315 98.27834.15YesNo097
53B:B:G288 B:B:V315 98.26323.68NoNo077
54B:B:C294 B:B:G288 98.24883.92NoNo057
55B:B:H54 B:B:W82 13.06363.17YesYes799
56B:B:D76 B:B:H54 12.2415.04YesYes799
57B:B:I93 B:B:P94 10.58963.39YesNo075
58B:B:K78 B:B:P94 10.82883.35YesNo085
59B:B:D76 B:B:K78 11.54448.3YesYes098
60B:B:D312 B:B:D333 99.92345.32NoYes059
61B:B:D312 R:R:K74 99.932615.21NoNo056
62R:R:H77 R:R:K74 99.94256.55NoNo076
63R:R:H77 R:R:Y82 99.95164.36NoNo074
64R:R:L160 R:R:Y82 99.96053.52YesNo074
65R:R:F83 R:R:L160 1004.87YesYes087
66R:R:F83 R:R:L163 28.6817.31YesNo086
67R:R:I140 R:R:L163 28.56914.28NoNo066
68R:R:I140 R:R:L136 28.46477.14NoYes067
69R:R:L136 R:R:L213 28.16255.54YesNo078
70R:R:L213 R:R:V132 27.75394.47NoNo087
71R:R:V132 R:R:W269 25.52394.9NoYes178
72L:L:?1 R:R:W269 32.35585.08YesYes108
73R:R:F83 R:R:I164 49.42443.77YesNo087
74R:R:I164 R:R:N86 49.33048.5NoYes079
75R:R:N86 R:R:S90 24.09964.47YesYes1798
76R:R:A130 R:R:S90 24.0253.42NoYes1778
77R:R:A130 R:R:S171 47.98233.42NoNo078
78R:R:S129 R:R:S171 47.24646.52NoNo068
79L:L:?1 R:R:S129 47.04255.59YesNo006
80R:R:N86 R:R:W168 25.00117.91YesYes1799
81R:R:A130 R:R:W168 24.2173.89NoYes1779
82L:L:?1 R:R:N101 13.797.15YesYes105
83R:R:N101 R:R:Y98 13.19953.49YesYes156
84R:R:F52 R:R:Y98 13.51425.16YesYes166
85L:L:?1 R:R:L297 13.3511.33YesNo005
86R:R:L297 R:R:Y98 12.905210.55NoYes056
87R:R:E141 R:R:F83 25.817312.83NoYes098
88R:R:E141 R:R:T145 23.89774.23NoNo098
89A:A:C351 R:R:T145 21.05995.07YesNo048
90A:A:C351 R:R:R142 16.87918.36YesYes1349
91R:R:D91 R:R:L87 15.47598.14YesNo099
92R:R:D91 R:R:N307 10.49568.08YesNo099
93L:L:?1 R:R:F125 14.202126.28YesYes105
94L:L:?1 R:R:L195 11.98785.15YesYes103
95R:R:F118 R:R:Y198 10.7774.13YesYes064
96A:A:L348 R:R:M146 17.35345.65NoNo098
97A:A:C351 R:R:M146 17.55783.24YesNo048
98A:A:L348 R:R:K250 15.62874.23NoYes996
99A:A:D341 R:R:K250 15.33338.3YesYes986
100A:A:F250 A:A:I264 27.54093.77YesYes096
101A:A:I221 A:A:I264 30.4817.36NoYes086
102A:A:F259 A:A:I221 30.6678.79YesNo2698
103A:A:F250 A:A:F307 18.13547.5YesYes098
104A:A:L266 A:A:L268 14.49194.15NoNo098
105A:A:F259 A:A:N256 24.37654.83YesNo098
106A:A:W258 B:B:R314 21.46675YesYes1458
107A:A:N256 A:A:W258 24.479510.17NoYes085
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K34 R:R:Y29 7.17 1 No Yes 6 7 2 1
R:R:T109 R:R:Y29 4.99 1 Yes Yes 5 7 1 1
R:R:Y110 R:R:Y29 7.94 1 Yes Yes 5 7 2 1
R:R:W117 R:R:Y29 6.75 1 Yes Yes 9 7 2 1
R:R:P196 R:R:Y29 13.91 1 No Yes 3 7 2 1
L:L:?1 R:R:Y29 5.23 1 Yes Yes 0 7 0 1
R:R:K34 R:R:P196 10.04 1 No No 6 3 2 2
R:R:N101 R:R:Y98 3.49 1 Yes Yes 5 6 1 2
R:R:M124 R:R:Y98 8.38 1 No Yes 6 6 2 2
R:R:L297 R:R:Y98 10.55 0 No Yes 5 6 1 2
R:R:N101 R:R:S105 7.45 1 Yes Yes 5 4 1 1
R:R:N101 R:R:R120 8.44 1 Yes Yes 5 6 1 1
R:R:M124 R:R:N101 4.21 1 No Yes 6 5 2 1
L:L:?1 R:R:N101 7.15 1 Yes Yes 0 5 0 1
R:R:R120 R:R:S105 3.95 1 Yes Yes 6 4 1 1
L:L:?1 R:R:S105 7.82 1 Yes Yes 0 4 0 1
R:R:T109 R:R:Y110 3.75 1 Yes Yes 5 5 1 2
R:R:R120 R:R:T109 5.17 1 Yes Yes 6 5 1 1
L:L:?1 R:R:T109 5.48 1 Yes Yes 0 5 0 1
R:R:L112 R:R:R120 3.64 0 No Yes 5 6 2 1
R:R:R120 R:R:W117 8 1 Yes Yes 6 9 1 2
R:R:E121 R:R:W117 23.99 1 Yes Yes 5 9 1 2
R:R:W117 R:R:Y198 4.82 1 Yes Yes 9 4 2 2
R:R:E121 R:R:R120 17.45 1 Yes Yes 5 6 1 1
L:L:?1 R:R:R120 7.23 1 Yes Yes 0 6 0 1
R:R:E121 R:R:L195 6.63 1 Yes Yes 5 3 1 1
R:R:E121 R:R:Y198 4.49 1 Yes Yes 5 4 1 2
L:L:?1 R:R:E121 3.94 1 Yes Yes 0 5 0 1
R:R:F125 R:R:Y198 10.32 1 Yes Yes 5 4 1 2
R:R:F125 R:R:Y202 4.13 1 Yes Yes 5 7 1 2
R:R:C206 R:R:F125 4.19 1 No Yes 6 5 2 1
L:L:?1 R:R:F125 26.28 1 Yes Yes 0 5 0 1
R:R:L128 R:R:W269 7.97 1 No Yes 6 8 1 1
L:L:?1 R:R:L128 10.3 1 Yes No 0 6 0 1
R:R:S129 R:R:S171 6.52 0 No No 6 8 1 2
L:L:?1 R:R:S129 5.59 1 Yes No 0 6 0 1
R:R:F265 R:R:V132 5.24 1 Yes No 9 7 2 2
R:R:V132 R:R:W269 4.9 1 No Yes 7 8 2 1
R:R:L195 R:R:V194 4.47 1 Yes Yes 3 4 1 2
R:R:L195 R:R:Y198 8.21 1 Yes Yes 3 4 1 2
L:L:?1 R:R:L195 5.15 1 Yes Yes 0 3 0 1
R:R:Y198 R:R:Y202 6.95 1 Yes Yes 4 7 2 2
R:R:C206 R:R:Y202 9.41 1 No Yes 6 7 2 2
R:R:F210 R:R:F265 4.29 1 Yes Yes 7 9 2 2
R:R:F210 R:R:W269 13.03 1 Yes Yes 7 8 2 1
R:R:F265 R:R:W269 10.02 1 Yes Yes 9 8 2 1
R:R:F265 R:R:N303 7.25 1 Yes Yes 9 9 2 2
R:R:L272 R:R:W269 3.42 1 No Yes 6 8 1 1
R:R:A300 R:R:W269 3.89 0 No Yes 7 8 2 1
R:R:N303 R:R:W269 7.91 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W269 5.08 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L272 4.12 1 Yes No 0 6 0 1
L:L:?1 R:R:L297 11.33 1 Yes No 0 5 0 1
R:R:L104 R:R:R120 2.43 0 No Yes 4 6 2 1
R:R:G106 R:R:S105 1.86 0 No Yes 4 4 2 1
R:R:F125 R:R:G122 1.51 1 Yes No 5 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
84.62Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
78.57Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
75.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
69.23Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
68.75Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
68.75Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
66.67Single7C4SS1P7C4S-S1P3-S1P
66.67Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
66.67Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
63.16Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
61.11Consensuslpl_onOrthosteric Ligands1p_on lpa_on
60.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
57.14Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
56.25Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
53.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
53.33Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
53.33Consensuss1p_offOrthosteric Ligands1p1_off
52.94Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
52.94Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
52.94Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
52.63Consensuslpl_offOrthosteric Ligands1p_off lpa_off
52.38Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
50.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
50.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
50.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
47.37Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
47.37Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
47.37Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
47.37Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
47.37Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
47.37Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
45.45Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
45.00Single5ZTYAM102575ZTY-CB2-AM10257
45.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
45.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
45.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
44.44Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
44.44Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
44.44Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
44.44Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
44.44Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
44.44Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
44.44Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
44.44Consensuslpa_offOrthosteric Ligandlpa1_off
44.44Consensuslpa_onOrthosteric Ligandlpa1_on
44.44Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
43.75Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
43.75Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
42.86Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
42.11Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
42.11Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
42.11Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
42.11Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
42.11Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
42.11Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
41.18Single6DRXLisuride6DRX-5-HT2B-Lisuride
41.18Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
41.18Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
41.18Consensusblt_onOrthosteric Ligandblt1_on
41.18Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
41.18Consensusgi_hcarOrthosteric Ligandgi_hca
41.18Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
41.18Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
41.18Consensusleuko_onOrthosteric Ligandblt_on
41.18Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
40.91Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
40.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
40.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
40.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
40.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
38.89Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
38.89Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
38.89Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
38.89Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
38.89Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
38.89Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
38.89Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
38.10Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
38.10Single7SK9CCX6627SK9-ACKR3-CCX662
38.10Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
38.10Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
38.10Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
37.50Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.84Single4DJHJDTic4DJH-κ-JDTic
36.84Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
36.84Single6TQ7SB-3348676TQ7-OX1-SB-334867
36.84Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
36.84Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
36.84Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
36.84Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
36.84Single8E0GBU728E0G-μ-BU72
36.84Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.84Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
36.84Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
36.84Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
36.84Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
36.84Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
36.36Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.36Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
36.36Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
36.36Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
36.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
36.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
35.71Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
35.29Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
35.29Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
35.29Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
35.29Single6ZG9GSK10347026ZG9-M1-GSK1034702
35.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.29Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
35.29Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
35.29Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
35.29Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.29Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
35.29Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
35.29Single8K5CAcipimox8K5C-HCA2-Acipimox
35.29Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
35.29Consensus5ht5_onOrthosteric Ligand5ht5a_on
35.29Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
35.29Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
35.29Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
35.29Consensussensory_offOrthosteric Ligandopsin_off
35.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
35.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
35.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
35.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
35.00Single7DFPSpiperone7DFP-D2-Spiperone
35.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
35.00Single7YITNalfurafine7YIT-κ-Nalfurafine
35.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
35.00Single8JWZAB9288JWZ-A2A-AB928-Na
35.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
35.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
35.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
35.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
35.00Consensuschemokine_offOrthosteric Ligandcxcr_off
35.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
35.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
35.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
35.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
35.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
35.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
34.78Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
34.78Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single2Y04Salbutamol2Y04-β1-Salbutamol
33.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
33.33Single4MQSIperoxo4MQS-M2-Iperoxo
33.33Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
33.33Single4U14Tiotropium4U14-M3-Tiotropium
33.33Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single5TGZAM65385TGZ-CB1-AM6538
33.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
33.33Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
33.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
33.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
33.33Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
33.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
33.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
33.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
33.33Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
33.33Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
33.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
33.33Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
33.33Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
33.33Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
33.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
33.33Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
33.33Consensustar_onOrthosteric Ligandta1_on
32.14Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
32.14Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
32.14Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
32.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
32.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
32.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
32.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
32.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
32.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Single4UG2CGS216804UG2-A2A-CGS21680
31.82Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
31.82Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.82Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
31.82Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
31.82Single8X5YAstemizole8X5Y-H1-Astemizole
31.82Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.82Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
31.82Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
31.82Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single2Y03Isoprenaline2Y03-β1-Isoprenaline
31.58Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
31.58Single5C1MBU725C1M-μ-BU72
31.58Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
31.58Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
31.58Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single6TP6Filorexant6TP6-OX1-Filorexant
31.58Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
31.58Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
31.58Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.58Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Single7YXAONO-54306087YXA-S1P5-ONO-5430608
31.58Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
31.58Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
31.58Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
31.58Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
31.58Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
31.58Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.58Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.58Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
31.58Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
31.58Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.58Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
31.25Single7SRQLSD7SRQ-5-HT2B-LSD
31.25Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
31.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
31.25Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8K5BNiacin8K5B-HCA2-Niacin
31.25Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
31.25Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
31.03Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.77Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single4XT1Fractalkine4XT1-US28-Fractalkine
30.43Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
30.43Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
30.43Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
30.43Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
30.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
30.43Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.43Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.43Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
30.43Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
30.00Single2YDVNECA2YDV-A2A-NECA
30.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
30.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
30.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
30.00Single4U15Tiotropium4U15-M3-Tiotropium
30.00Single4UHRCGS216804UHR-A2A-CGS21680
30.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
30.00Single5G53NECA5G53-A2A-NECA-Gs
30.00Single5X93K-87945X93-ETB-K-8794
30.00Single5XR8AM8415XR8-CB1-AM841
30.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
30.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
30.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
30.00Single6OL9Tiotropium6OL9-M5-Tiotropium
30.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
30.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
30.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
30.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
30.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
30.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
30.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
30.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
30.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
30.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
30.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
30.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
30.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
30.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
30.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
30.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
30.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
30.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
30.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
30.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
30.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
30.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
30.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
30.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.63Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.63Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
29.41Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
29.41Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
29.41Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
29.41Single6AKXA4R6AKX-CCR5-A4R
29.41Single6AKYMaraviroc6AKY-CCR5-Maraviroc
29.41Single6B73PubChem 1319551386B73-κ-PubChem 131955138
29.41Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
29.41Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
29.41Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
29.41Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
29.41Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
29.41Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
29.41Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
29.41Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
29.41Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
29.41Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
29.41Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
29.41Single8IHKAcifran8IHK-HCA3-Acifran
29.41Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Consensusalpha1_onOrthosteric Ligandalpha1a_on
29.41Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
29.41Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
29.41Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
29.41Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
29.41Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
29.41Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
29.41Consensusorexin_offOrthosteric Ligandox2_off ox1_off
29.17Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
29.17Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
29.17Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
29.17Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.57Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
28.57Single4AMIBucindolol4AMI-β1-Bucindolol
28.57Single4LDEBI1671074LDE-β2-BI167107
28.57Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
28.57Single5CXVTiotropium5CXV-M1-Tiotropium
28.57Single6A93Risperidone6A93-5-HT2A-Risperidone
28.57Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
28.57Single6CM4Risperidone6CM4-D2-Risperidone
28.57Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
28.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
28.57Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
28.57Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
28.57Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
28.57Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
28.57Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
28.57Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
28.57Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
28.57Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
28.57Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
28.57Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
28.57Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
28.57Consensusblt_offOrthosteric Ligandblt1_off
28.57Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
28.57Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
28.57Consensusdp_offOrthosteric Liganddp2_off
28.57Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
28.57Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
28.57Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57Consensusgs_steroidOrthosteric Ligandgs_bileacid
28.57Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
28.57Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
28.00Single5WF5UK-4320975WF5-A2A-UK-432097
28.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.00Single6PT2KGCHM076PT2-δ-KGCHM07
28.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
28.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
28.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
28.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
27.78Single2YDOAdenosine2YDO-A2A-Adenosine
27.78Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
27.78Single3RZECidoxepin3RZE-H1-Cidoxepin
27.78Single4MBSMaraviroc4MBS-CCR5-Maraviroc
27.78Single4ZJCSB-6740424ZJC-OX1-SB-674042
27.78Single6IQLL7458706IQL-D4-L745870
27.78Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6TP3Nemorexant6TP3-OX1-Nemorexant
27.78Single6TPGEMPA6TPG-OX2-EMPA
27.78Single6TPNHTL66416TPN-OX2-HTL6641
27.78Single6V9SGTPL114036V9S-OX1-GTPL11403
27.78Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
27.78Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
27.78Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
27.78Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
27.78Single7T32ZM2413857T32-A2A-ZM241385
27.78Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
27.78Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
27.78Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
27.78Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
27.78Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
27.78Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
27.78Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
27.78Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
27.78Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
27.78Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
27.78Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
27.78Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
27.78Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
27.78Consensushca_onOrthosteric Ligandhca2_on hca3_on
27.78Consensushcar_onOrthosteric Ligandhca_on
27.78Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
27.59Single6IGLIRL16206IGL-ETB-IRL1620
27.59Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
27.27Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
27.27Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
27.27Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
27.27Single6K1QIRL25006K1Q-ETB-IRL2500
27.27Single7EZCUKA7EZC-A2A-UKA
27.27Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
27.27Single7UM4AS26747237UM4-5-HT5A-AS2674723
27.27Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
27.27Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
27.27Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
27.27Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
27.27Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
27.27Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
27.27Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensussteroid_onOrthosteric Ligandbileacid_on
26.92Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
26.92Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
26.92Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.92Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
26.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
26.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
26.32Single3NY8ICI 118-5513NY8-β2-ICI 118-551
26.32Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
26.32Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
26.32Single4DAJTiotropium4DAJ-M3-Tiotropium
26.32Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
26.32Single4EJ4Naltrindole4EJ4-δ-Naltrindole
26.32Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
26.32Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
26.32Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
26.32Single4YAYZD-71554YAY-AT1-ZD-7155
26.32Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
26.32Single5DSGTiotropium5DSG-M4-Tiotropium
26.32Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
26.32Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
26.32Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
26.32Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
26.32Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
26.32Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
26.32Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
26.32Single6H7MSalbutamol6H7M-β1-Salbutamol
26.32Single6IIVDaltroban6IIV-TP-Daltroban
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
26.32Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
26.32Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6TOTLemborexant6TOT-OX1-Lemborexant
26.32Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
26.32Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
26.32Single7F83PF-051904577F83-Ghrelin-PF-05190457
26.32Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
26.32Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
26.32Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
26.32Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
26.32Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
26.32Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.32Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
26.32Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
26.32Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.32Single8JJOAlprenolol8JJO-β2-Alprenolol
26.32Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8K5DGSK2560738K5D-HCA2-GSK256073
26.32Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
26.32Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.32Single8X63Mepyramine8X63-H1-Mepyramine
26.32Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
26.32Consensusadenosine_onOrthosteric Liganda1_on a2_on
26.32Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
26.32Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.32Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
26.32Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
26.32Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
26.32Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Consensushcar_offOrthosteric Ligandsuccinate_off
26.32Consensushistamine_onOrthosteric Ligandh1_on h4_on
26.32Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
26.32Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.32Consensusnucleotide_onOrthosteric Ligandadenosine_on
26.32Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
26.32Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
26.09Single3NY9PubChem 9131033NY9-β2-PubChem 913103
26.09Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
26.09Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
26.09Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
26.09Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
26.09Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
26.09Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
26.09Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
26.09Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.09Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
26.09Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
26.09Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.93Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
25.93Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
25.93Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
25.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
25.93Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.93Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.81Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
25.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
25.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
25.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
25.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
25.00Single4XT3Fractalkine4XT3-US28-Fractalkine
25.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
25.00Single5NM2ZM2413855NM2-A2A-ZM241385-Na
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5TVNLSD5TVN-5-HT2B-LSD
25.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
25.00Single5WIUNemonapride5WIU-D4-Nemonapride
25.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
25.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single5WQCEMPA5WQC-OX2-EMPA
25.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
25.00Single5XPRBosentan5XPR-ETB-Bosentan
25.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
25.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
25.00Single6LI0GTPL98046LI0-GPR52-GTPL9804
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
25.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
25.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
25.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
25.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
25.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
25.00Single7WC6LSD7WC6-5-HT2A-LSD
25.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8EA0Iperoxo8EA0-M3-Iperoxo
25.00Single8GGREpinephrine8GGR-β2-Epinephrine
25.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
25.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
25.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
25.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
25.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
25.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
25.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
25.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
25.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
25.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
25.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
25.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
25.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
25.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
25.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
25.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
25.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
25.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
25.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
25.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
24.24Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
24.14Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
24.14Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
24.14Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
24.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Consensusendothelin_onOrthosteric Ligandetb_on eta_on
24.00Single3QAKUK-4320973QAK-A2A-UK-432097
24.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
24.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
24.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
24.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
24.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
24.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
23.81Single3P0GBI1671073P0G-β2-BI167107
23.81Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
23.81Single4RWADIPP-NH24RWA-δ-DIPP-NH2
23.81Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
23.81Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
23.81Single5TZR-5TZR-FFA1 (GPR40)-MK8666
23.81Single5V54Methiothepin5V54-5-HT1B-Methiothepin
23.81Single5XRAAM115425XRA-CB1-AM11542
23.81Single6E59L-7607356E59-NK1-L-760735
23.81Single6J20Aprepitant6J20-NK1-Aprepitant
23.81Single6J21Aprepitant6J21-NK1-Aprepitant
23.81Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
23.81Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
23.81Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
23.81Single6WGTLSD6WGT-5-HT2A-LSD
23.81Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
23.81Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
23.81Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
23.81Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.81Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.81Single7W41PD1762527W41-BB2-PD176252
23.81Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
23.81Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
23.81Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
23.81Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
23.81Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
23.81Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.81Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
23.81Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
23.81Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
23.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
23.81Consensus5ht1_offOrthosteric Ligand5ht1b_off
23.81Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
23.81Consensus5ht5_offOrthosteric Ligand5ht5a_off
23.81Consensusa2_onOrthosteric Liganda2a_on a2b_on
23.81Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
23.81Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.81Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
23.81Consensusbombesin_offOrthosteric Ligandbb2_off
23.81Consensuscck_onOrthosteric Ligandccka_on cckb_on
23.81Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
23.81Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
23.81Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
23.81Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
23.81Consensushistamine_offOrthosteric Ligandh1_off
23.81Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
23.53Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
23.53Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
23.53Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
23.53Single3OE9IT1t3OE9-CXCR4-IT1t
23.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
23.53Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.53Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
23.53Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
23.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GGSEpinephrine8GGS-β2-Epinephrine
23.53Single8GGYEpinephrine8GGY-β2-Epinephrine
23.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
23.53Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
23.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
23.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
23.53Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
23.53Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.53Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
23.33Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
23.33Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
23.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
23.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
23.33Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.33Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
23.08Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
23.08Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
23.08Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
23.08Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
23.08Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
22.73Single5X33BIIL2605X33-BLT1-BIIL260
22.73Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
22.73Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
22.73Single6IIURamatroban6IIU-TP-Ramatroban
22.73Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
22.73Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.73Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
22.73Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
22.73Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
22.73Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
22.73Single8JJ8Formoterol8JJ8-β2-Formoterol
22.73Single8JJLOlodaterol8JJL-β2-Olodaterol
22.73Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
22.73Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
22.73Consensusclass-b2_onOrthosteric Ligandadgrg_on
22.73Consensusgi_class-fOther Ligandgi_frizzled
22.73Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
22.58Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
22.22Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
22.22Single3ODUIT1t3ODU-CXCR4-IT1t
22.22Single3PWHZM2413853PWH-A2A-ZM241385
22.22Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
22.22Single4S0VSuvorexant4S0V-OX2-Suvorexant
22.22Single5WS3EMPA5WS3-OX2-EMPA
22.22Single5ZKQABT-4915ZKQ-PAF-ABT-491
22.22Single6KUXRS-799486KUX-α2a-RS-79948
22.22Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
22.22Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Single6TODEMPA6TOD-OX1-EMPA-Na
22.22Single6TPJSuvorexant6TPJ-OX2-Suvorexant
22.22Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
22.22Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
22.22Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
22.22Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
22.22Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
22.22Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
22.22Single7XRRLemborexant7XRR-OX2-Lemborexant
22.22Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
22.22Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.22Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
22.22Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGVEpinephrine8GGV-β2-Epinephrine
22.22Single8GGWEpinephrine8GGW-β2-Epinephrine
22.22Single8GGXEpinephrine8GGX-β2-Epinephrine
22.22Single8GH0Epinephrine8GH0-β2-Epinephrine
22.22Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
22.22Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
22.22Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
22.22Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.22Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8IWESpermidine8IWE-TAAR9-Spermidine
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
22.22Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
22.22Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
22.22Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
22.22Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
22.22Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
22.22Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
22.22Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.22Consensusgt_class-aOrthosteric Ligandgt_opsin
22.22Consensusgt_opsinOrthosteric Ligandgt_sensory
22.22Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.22Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
22.22Consensusmglu_onOther Ligandmglu2_on mglu4_on
22.22Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
21.88Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.88Consensusglp_onOrthosteric Ligandglp1_on glp2_on
21.74Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
21.74Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
21.74Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
21.74Single6H7LDobutamine6H7L-β1-Dobutamine
21.74Single6IBLArformoterol6IBL-β1-Arformoterol
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
21.74Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
21.74Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
21.74Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
21.43Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
21.43Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
21.43Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
21.43Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
21.43Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.43Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
21.43Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
21.43Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
21.43Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
21.05Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
21.05Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
21.05Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
21.05Single5IU7Q274563465IU7-A2A-Q27456346-Na
21.05Single5JTBZM2413855JTB-A2A-ZM241385
21.05Single5K2BZM2413855K2B-A2A-ZM241385-Na
21.05Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
21.05Single6A94Zotepine6A94-5-HT2A-Zotepine
21.05Single6AQFZM2413856AQF-A2A-ZM241385
21.05Single6DS0Ly2660976DS0-5-HT2B-Ly266097
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single6MH8ZM2413856MH8-A2A-ZM241385
21.05Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
21.05Single6PS4ICI 118-5516PS4-β2-ICI 118-551
21.05Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
21.05Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
21.05Single6TPKRetosiban6TPK-OT-Retosiban
21.05Single6VI4JDTic6VI4-κ-JDTic
21.05Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
21.05Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
21.05Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
21.05Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
21.05Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
21.05Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
21.05Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
21.05Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
21.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
21.05Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
21.05Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.05Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
21.05Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
21.05Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8GGIEpinephrine8GGI-β2-Epinephrine
21.05Single8GGKEpinephrine8GGK-β2-Epinephrine
21.05Single8GGMEpinephrine8GGM-β2-Epinephrine
21.05Single8GGPEpinephrine8GGP-β2-Epinephrine
21.05Single8GGQEpinephrine8GGQ-β2-Epinephrine
21.05Single8GGTEpinephrine8GGT-β2-Epinephrine
21.05Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
21.05Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
21.05Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.05Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
21.05Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
21.05Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
21.05Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
21.05Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
21.05Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
21.05Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
21.05Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
21.05Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
21.05Consensusvasopressin-ot_offOrthosteric Ligandot_off
20.83Single5EE7MK08935EE7-Glucagon-MK0893
20.83Single5WF6UK-4320975WF6-A2A-UK-432097
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.83Single6PT3DPI-2876PT3-δ-DPI-287
20.83Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Consensusclass-d_offOrthosteric Ligandste2_off
20.83Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.83Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single6FJ3PTH6FJ3-PTH1-PTH
20.69Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
20.69Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.69Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7SK3CXCL127SK3-ACKR3-CXCL12
20.69Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
20.69Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
20.69Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.69Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.59Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.59Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
20.59Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
20.59Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.59Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
20.59Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.59Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.59Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
20.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single2Y01Dobutamine2Y01-β1-Dobutamine
20.00Single2Y02Carmoterol2Y02-β1-Carmoterol
20.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.00Single3EMLZM2413853EML-A2A-ZM241385
20.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
20.00Single4EIYZM2413854EIY-A2A-ZM241385-Na
20.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
20.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
20.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
20.00Single5K2AZM2413855K2A-A2A-ZM241385-Na
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
20.00Single5OLGZM2413855OLG-A2A-ZM241385-Na
20.00Single5T04Neurotensin5T04-NTS1-Neurotensin
20.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
20.00Single5VRAZM2413855VRA-A2A-ZM241385-Na
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
20.00Single6PS1Timolol6PS1-β2-Timolol
20.00Single6S0LZM2413856S0L-A2A-ZM241385
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
20.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
20.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
20.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
20.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
20.00Single7BU7BI1671077BU7-β1-BI167107
20.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
20.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
20.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
20.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
20.00Single7F8XNN90567F8X-CCKA-NN9056
20.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
20.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
20.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.00Single7PYRPSB-21157PYR-A2A-PSB-2115
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7QA8Peptide7QA8-STE2-Peptide
20.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
20.00Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
20.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
20.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
20.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
20.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
20.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
20.00Single8CU6LJ-45178CU6-A2A-LJ-4517
20.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
20.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
20.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
20.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
20.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
20.00Single8GGNEpinephrine8GGN-β2-Epinephrine
20.00Single8GGOEpinephrine8GGO-β2-Epinephrine
20.00Single8GGUEpinephrine8GGU-β2-Epinephrine
20.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
20.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
20.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
20.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8X64Desloratadine8X64-H1-Desloratadine
20.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
20.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
20.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
20.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
20.00Consensusa2_offOrthosteric Liganda2a_off
20.00Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
20.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
20.00Consensusclass-d_offOrthosteric Ligandste2_off
20.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
20.00Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
20.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
20.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
20.00Consensusgo_class-b1Orthosteric Ligandgo_crf
20.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
20.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
20.00Consensuspth_onOrthosteric Ligandpth1_on pth2_on
20.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.00Consensustachykinin_offOrthosteric Ligandnk1_off
19.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
19.35Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
19.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
19.35Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
19.35Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.35Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
19.35Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
19.35Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.35Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
19.23Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
19.23Single6HLOAprepitant6HLO-NK1-Aprepitant
19.23Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
19.23Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
19.23Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
19.23Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
19.23Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
19.05Single2Y00Dobutamine2Y00-β1-Dobutamine
19.05Single5CGCHTL142425CGC-mGlu5-HTL14242
19.05Single5IUAQ274563485IUA-A2A-Q27456348-Na
19.05Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
19.05Single5N2SPSB365N2S-A1-PSB36
19.05Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.05Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.05Single6GPXMK08126GPX-CCR2-MK0812
19.05Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
19.05Single6LPLZM2413856LPL-A2A-ZM241385-Na
19.05Single6LUQHaloperidol6LUQ-D2-Haloperidol
19.05Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
19.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
19.05Single6S0QZM2413856S0Q-A2A-ZM241385
19.05Single6WQAZM2413856WQA-A2A-ZM241385-Na
19.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
19.05Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
19.05Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.05Single7RM5ZM2413857RM5-A2A-ZM241385-Na
19.05Single7SINNPS-21437SIN-CaS-NPS-2143
19.05Single7SINNPS-21437SIN-CaS-NPS-2143
19.05Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
19.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
19.05Single7XKAEpinephrine7XKA-β2-Epinephrine
19.05Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
19.05Single8FYNZM2413858FYN-A2A-ZM241385-Na
19.05Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
19.05Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
19.05Single8GNEKW-63568GNE-A2A-KW-6356-Na
19.05Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
19.05Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
19.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
19.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
19.05Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
19.05Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.05Consensusep_offOrthosteric Ligandep4_off
19.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.92Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
18.92Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
18.75Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
18.75Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
18.75Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.75Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.75Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.75Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
18.75Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
18.75Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
18.75Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
18.52Single3OE0CVX153OE0-CXCR4-CVX15
18.52Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
18.52Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.42Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
18.18Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
18.18Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
18.18Single4BV0Neurotensin4BV0-NTS1-Neurotensin
18.18Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
18.18Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single6OS1TRV0266OS1-AT1-TRV026
18.18Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
18.18Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
18.18Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
18.18Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
18.18Single7PX4PSB-21137PX4-A2A-PSB-2113
18.18Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
18.18Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
18.18Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
18.18Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
18.18Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.18Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
18.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
18.18Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.18Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
18.18Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
18.18Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
18.18Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.18Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.86Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
17.86Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.86Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
17.86Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
17.86Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
17.86Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
17.86Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
17.65Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
17.65Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
17.65Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
17.65Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
17.65Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
17.65Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
17.65Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
17.65Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
17.65Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single7WC5Psilocin7WC5-5-HT2A-Psilocin
17.65Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
17.65Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.65Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
17.65Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
17.65Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
17.39Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.39Single4XEENeurotensin4XEE-NTS1-Neurotensin
17.39Single4XESNeurotensin4XES-NTS1-Neurotensin
17.39Single6HLPNetupitant6HLP-NK1-Netupitant
17.39Single6MXTSalmeterol6MXT-β2-Salmeterol
17.39Single6OS2TRV0266OS2-AT1-TRV026
17.39Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
17.39Single6YVRNTS8-136YVR-NTS1-NTS8-13
17.39Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
17.39Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
17.39Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
17.39Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.39Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
17.39Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
17.39Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
17.39Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.39Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.24Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
17.24Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.24Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
17.24Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.24Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.24Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
17.24Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.14Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
16.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
16.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single5CGDHTL142425CGD-mGlu5-HTL14242
16.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
16.67Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
16.67Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.67Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
16.67Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
16.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
16.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
16.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
16.67Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
16.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
16.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
16.67Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GH1Epinephrine8GH1-β2-Epinephrine
16.67Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
16.67Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
16.67Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
16.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
16.67Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
16.67Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
16.67Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
16.67Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.67Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
16.67Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
16.67Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.13Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.13Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
16.13Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.13Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
16.13Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.13Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
16.13Consensusgi_class-dOrthosteric Ligandgi_ste
16.13Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
16.13Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.13Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.13Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
16.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
16.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
16.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
16.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
15.79Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
15.79Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.79Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.79Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
15.79Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.79Single5DHHSB-6121115DHH-NOP-SB-612111
15.79Single5K2DZM2413855K2D-A2A-ZM241385
15.79Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
15.79Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.79Single6JZHZM2413856JZH-A2A-ZM241385-Na
15.79Single6PS7ZM2413856PS7-A2A-ZM241385-Na
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
15.79Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
15.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
15.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
15.79Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
15.79Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
15.79Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
15.79Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8GNGIstradefylline8GNG-A2A-Istradefylline
15.79Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
15.79Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.79Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.79Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.79Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
15.79Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
15.62Single6LMLGlucagon6LML-Glucagon-Glucagon
15.62Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.62Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
15.62Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
15.38Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
15.38Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
15.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
15.38Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.38Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
15.38Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
15.38Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
15.38Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
15.15Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single3REYPubChem 56973REY-A2A-PubChem 5697
15.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
15.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
15.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
15.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
15.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
15.00Single5UVIZM2413855UVI-A2A-ZM241385
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
15.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
15.00Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
15.00Single7AROLUF58337ARO-A2A-LUF5833-Na
15.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
15.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8GGLEpinephrine8GGL-β2-Epinephrine
15.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8K2WAMG4878K2W-CXCR3-AMG487
15.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
15.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
15.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
15.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
15.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
14.81Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
14.81Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.81Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
14.63Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
14.29Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
14.29Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
14.29Single5UENDU1725UEN-A1-DU172
14.29Single6D27CAY104716D27-DP2-CAY10471
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6LPJZM2413856LPJ-A2A-ZM241385-Na
14.29Single6LPKZM2413856LPK-A2A-ZM241385-Na
14.29Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
14.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7XNACYN1548067XNA-SST2-CYN154806
14.29Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
14.29Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
14.29Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
14.29Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
14.29Consensuscck_offOrthosteric Ligandccka_off
14.29Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
14.29Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
14.29Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
14.29Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.29Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
14.29Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.79Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.79Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.79Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.64Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
13.64Single4NTJAZD12834NTJ-P2Y12-AZD1283
13.64Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.64Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
13.64Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
13.64Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.64Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
13.64Single8QOTNanobody E8QOT-μ-Nanobody E
13.64Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
13.64Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
13.64Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.51Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.51Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
13.51Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
13.33Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
13.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.33Single6W25Ca6W25-MC4-SHU9119-Ca
13.33Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
13.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.33Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single5V56TC1145V56-SMO-TC114
13.04Single5V57TC1145V57-SMO-TC114
13.04Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
13.04Single7EPENAM5637EPE-mGlu-NAM563
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7P2L4YI7P2L-mGlu5-4YI
13.04Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
13.04Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.04Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.04Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
13.04Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.04Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
13.04Consensuschemerin_onOrthosteric Ligandcml1_on
13.04Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
13.04Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.04Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
13.04Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.90Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.90Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
12.50Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
12.50Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.50Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
12.50Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.50Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
12.50Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
12.50Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
12.50Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
12.50Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
12.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.50Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.50Consensusnts_onOrthosteric Ligandnts1_on
12.50Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.50Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
12.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
12.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
12.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
12.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
12.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
12.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.00Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
12.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
11.76Single3RFMCaffeine3RFM-A2A-Caffeine
11.76Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.76Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
11.76Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.76Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.76Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
11.76Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.76Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
11.76Consensussensory_onOrthosteric Ligandopsin_on
11.54Single6KNMJN241-96KNM-Apelin-JN241-9
11.54Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
11.54Single7XN9L-054,5227XN9-SST2-L-054,522
11.54Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
11.54Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
11.11Single3UZAGTPL92363UZA-A2A-GTPL9236
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
11.11Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.11Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
11.11Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
11.11Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
11.11Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
11.11Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
11.11Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.11Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
11.11Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.11Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.81Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
10.71Single7SK5CXCL127SK5-ACKR3-CXCL12
10.71Consensussst_offOrthosteric Ligandsst2_off
10.53Single3PBLEticlopride3PBL-D3-Eticlopride
10.53Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.53Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.53Single5L7IVismodegib5L7I-SMO-Vismodegib
10.53Single6HLLCP999946HLL-NK1-CP99994
10.53Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
10.53Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
10.53Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.53Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
10.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.53Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
10.53Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
10.53Consensusclass-t_onOrthosteric Ligandtaste2_on
10.53Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
10.53Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.53Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.53Consensusgo_class-b2Orthosteric Ligandgo_adhesion
10.53Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.53Consensusgs_class-tOrthosteric Ligandgs_taste
10.53Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.53Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
10.53Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.00Single4QINSAG1.54QIN-SMO-SAG1.5
10.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
10.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
10.00Single7F8ULintitript7F8U-CCKA-Lintitript
10.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Consensusclass-d_onOrthosteric Ligandste2_on
10.00Consensusclass-f_offOrthosteric Ligandsmo_off
10.00Consensusgi_class-dOrthosteric Ligandgi_ste
10.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
9.52Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
9.52Single7VV6C48/807VV6-MRGPRX2-C48/80
9.52Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
9.52Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.52Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
9.52Single8IYXYL-3658IYX-GPR34-YL-365
9.52Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
9.52Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensusgi_class-fOrthosteric Ligandgi_frizzled
9.52Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.52Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.52Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.38Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.09Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
9.09Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
8.82Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
8.70Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.70Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
8.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.33Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.33Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
8.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
7.69Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.69Single6D35Cholesterol6D35-SMO-Cholesterol
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.69Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.69Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.69Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.69Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.69Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.69Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.69Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
7.69Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTTCa7DTT-CaS-Ca-Ca
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTUTryptophan7DTU-CaS-Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.69Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
7.69Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.69Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7FIIhCG7FII-LH-hCG-6fuf
7.69Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.69Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.69Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7.69Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
7.69Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.69Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.69Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
7.69Single7XW7K1-707XW7-TSH-K1-70
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.69Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.69Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.69Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.69Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
7.69Consensusclass-c_offOther Ligandgabab_off mglu_off
7.69Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.69Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
7.69Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.69Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.69Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.69Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
7.69Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
7.69Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusgphr_onOrthosteric Ligandlh_on tsh_on
7.69Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.69Consensusgs_proteinOrthosteric Ligandgs_gphr
7.69Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
7.69Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.69Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
7.69Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
7.69Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.69Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
7.69Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
7.69Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.69Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
7.69Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.69Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
7.69Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.69Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
7.69Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
7.69Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
7.69Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.50Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
6.98Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.90Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.67Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.67Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.25Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
6.25Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
6.25Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
6.25Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.25Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.88Single5L7DCholesterol5L7D-SMO-Cholesterol
5.88Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.88Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
5.88Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.88Consensusclass-c_onOther Ligandgabab_on mglu_on
5.71Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
5.56Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
5.56Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.56Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
5.56Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
5.56Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.41Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.26Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.26Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.26Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.26Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.13Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.13Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.88Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.76Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.76Single4XNVBPTU4XNV-P2Y1-BPTU
4.76Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.76Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.65Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
4.55Single6ZINSR486926ZIN-NTS1-SR48692
4.55Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.35Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.35Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.35Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.17Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
4.17Single6Z4SSR486926Z4S-NTS1-SR48692
4.17Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.85Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
3.85Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
3.85Consensusnts_offOrthosteric Ligandnts1_off
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.70Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.70Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.56Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3

PDB Summary
PDB 7VIG
Class A
SubFamily Lipid
Type Lysophospholipid (S1P)
SubType S1P1
Species Homo sapiens
Ligand CBP-307
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.89
Date 2022-09-28
D.O.I. 10.1073/pnas.2117716119
Net Summary
Imin 3.17
Number of Linked Nodes 863
Number of Links 1066
Number of Hubs 165
Number of Links mediated by Hubs 628
Number of Communities 31
Number of Nodes involved in Communities 264
Number of Links involved in Communities 388
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 1007228
Length Of Smallest Path 3
Average Path Length 33.2426
Length of Longest Path 75
Minimum Path Strength 1.21
Average Path Strength 6.43242
Maximum Path Strength 22.81
Minimum Path Correlation 0.71
Average Path Correlation 0.979439
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 44.5208
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.468
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code7I4
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code7I4
Name1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid
Synonyms
Identifier1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid
FormulaC23 H24 F N3 O3
Molecular Weight409.453
SMILESCC(C)Cc1ccc(cc1)c2nc(no2)c3ccc(c(c3)F)CN4CC(C4)C(=O)O
PubChem117972004
Formal Charge0
Total Atoms54
Total Chiral Atoms0
Total Bonds57
Total Aromatic Bonds17

PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7VIG_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7VIG_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP21453
Sequence
>7VIG_Chain_R
DIIVRHYNY TGKLNTSVV FILICCFII LENIFVLLT IWKTKKFHR 
PMYYFIGNL ALSDLLAGV AYTANLLLS GATTYKLTP AQWFLREGS 
MFVALSASV FSLLAIAIE RYITMLKMK LHNGSNNFR LFLLISACW 
VISLILGGL PIMGWNCIS ALSSCSTVL PLYHKHYIL FCTTVFTLL 
LLSIVILYC RIYSLVRTR SRRLTFEKS LALLKTVII VLSVFIACW 
APLFILLLL DVGCKVKTC DILFRAEYF LVLAVLNSG TNPIIYTLT 
NKEMRRAFI R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7VIG_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKS 
TIVKQMKII GIVETHFTF KDLHFKMFD VGGQRSERK KWIHCFEGV 
TAIIFCVAL SDYDLVLEE MNRMHESMK LFDSICNNK WFTDTSIIL 
FLNKKDLFE EKIKKSPLT ICYPEYAGS NTYEEAAAY IQCQFEDLN 
KRKDTKEIY THFTCATDT KNVQFVFDA VTDVIIKNN LKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
s1p1_on7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
gi_lpl7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3V2WALipidLysophospholipid (S1P)S1P1Homo sapiensPubChem 51892645--3.352012-02-1510.1126/science.1215904
3V2YALipidLysophospholipid (S1P)S1P1Homo sapiensPubChem 51892645--2.82012-02-1510.1126/science.1215904
7EO2ALipidLysophospholipid (S1P)S1P1Homo sapiensFTY720-P-Gi1/&β;1/&γ;22.892022-01-0510.1038/s41589-021-00930-3
7EO4ALipidLysophospholipid (S1P)S1P1Homo sapiensBAF312-Gi1/&β;1/&γ;22.862022-01-0510.1038/s41589-021-00930-3
7EVYALipidLysophospholipid (S1P)S1P1Homo sapiensSiponimod-Gi1/&β;1/&γ;22.982021-09-2910.1038/s41422-021-00566-x
7EVZALipidLysophospholipid (S1P)S1P1Homo sapiensCenerimod-Gi1/&β;1/&γ;23.072021-09-2910.1038/s41422-021-00566-x
7EW0ALipidLysophospholipid (S1P)S1P1Homo sapiensOzanimod-Gi1/&β;1/&γ;23.422021-09-2910.1038/s41422-021-00566-x
7EW7ALipidLysophospholipid (S1P)S1P1Homo sapiensPubChem 4077460-Gi1/&β;1/&γ;23.272021-09-2910.1038/s41422-021-00566-x
7TD3ALipidLysophospholipid (S1P)S1P1Homo sapiensS1P-Gi1/&β;1/&γ;232022-02-0910.1038/s41467-022-28417-2
7TD4ALipidLysophospholipid (S1P)S1P1Homo sapiensSiponimod-Gi1/&β;1/&γ;22.62022-02-0910.1038/s41467-022-28417-2
7VIEALipidLysophospholipid (S1P)S1P1Homo sapiensS1P-Gi1/&β;1/&γ;22.862022-09-2810.1073/pnas.2117716119
7VIFALipidLysophospholipid (S1P)S1P1Homo sapiens(S)-FTY720-P-Gi1/&β;1/&γ;22.832022-09-2810.1073/pnas.2117716119
7VIHALipidLysophospholipid (S1P)S1P1Homo sapiensCBP-307-Gi1/&β;1/&γ;22.982022-09-2810.1073/pnas.2117716119
7WF7ALipidLysophospholipid (S1P)S1P1Homo sapiensS1P-Gi1/&β;1/&γ;23.42022-01-0510.1038/s41589-021-00930-3
8G94ALipidLysophospholipid (S1P)S1P1Homo sapiens-CD69Gi1/&β;1/&γ;23.152023-04-1910.7554/eLife.88204




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