psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y29	6.21	Yes	Yes	1	0	7
2	L:L:?1	R:R:K34	8.4	Yes	No	1	0	6
3	L:L:?1	R:R:E121	8.77	Yes	Yes	1	0	5
4	L:L:?1	R:R:M124	3.74	Yes	Yes	1	0	6
5	L:L:?1	R:R:F125	16.94	Yes	No	0	0	5
6	L:L:?1	R:R:L128	5.5	Yes	No	1	0	6
7	L:L:?1	R:R:S129	7.95	Yes	No	0	0	6
8	L:L:?1	R:R:V132	3.95	Yes	No	0	0	7
9	L:L:?1	R:R:L195	8.25	Yes	Yes	1	0	3
10	L:L:?1	R:R:V209	2.96	Yes	No	0	0	5
11	L:L:?1	R:R:F210	12.1	Yes	No	1	0	7
12	L:L:?1	R:R:W269	4.53	Yes	Yes	1	0	8
13	L:L:?1	R:R:L272	6.42	Yes	No	1	0	6
14	L:L:?1	R:R:L276	9.17	Yes	Yes	1	0	6
15	L:L:?1	R:R:L297	8.25	Yes	No	1	0	5
16	R:R:D23	R:R:V26	4.38	No	No	0	7	6
17	R:R:H28	R:R:I24	5.3	Yes	No	0	8	4
18	R:R:H28	R:R:R27	4.51	Yes	No	0	8	3
19	R:R:H28	R:R:L188	6.43	Yes	No	0	8	2
20	R:R:C191	R:R:H28	4.42	No	Yes	0	9	8
21	R:R:H28	R:R:P196	6.1	Yes	No	0	8	3
22	R:R:H28	R:R:L197	6.43	Yes	Yes	0	8	4
23	R:R:K34	R:R:Y29	4.78	No	Yes	1	6	7
24	R:R:T109	R:R:Y29	3.75	No	Yes	0	5	7
25	R:R:W117	R:R:Y29	2.89	Yes	Yes	1	9	7
26	R:R:P196	R:R:Y29	5.56	No	Yes	0	3	7
27	R:R:L35	R:R:N30	2.75	No	No	0	6	9
28	R:R:L188	R:R:Y31	19.93	No	No	0	2	5
29	R:R:V284	R:R:Y31	2.52	No	No	0	1	5
30	R:R:S49	R:R:T48	3.2	No	No	0	5	5
31	R:R:T48	R:R:Y295	3.75	No	No	0	5	3
32	R:R:F52	R:R:V51	2.62	Yes	No	0	6	5
33	R:R:F52	R:R:Y98	5.16	Yes	Yes	1	6	6
34	R:R:F52	R:R:L102	4.87	Yes	No	1	6	5
35	R:R:F52	R:R:V298	15.73	Yes	No	1	6	5
36	R:R:I53	R:R:T99	4.56	No	No	0	3	6
37	R:R:C56	R:R:Y98	5.38	No	Yes	0	5	6
38	R:R:C56	R:R:T99	3.38	No	No	0	5	6
39	R:R:E62	R:R:F58	17.49	No	No	0	8	4
40	R:R:I59	R:R:N63	4.25	No	No	0	7	9
41	R:R:G305	R:R:I59	7.05	No	No	0	7	7
42	R:R:I60	R:R:L92	4.28	No	Yes	0	6	6
43	R:R:I60	R:R:V96	3.07	No	No	0	6	5
44	R:R:E62	R:R:I309	6.83	No	No	0	8	6
45	R:R:L92	R:R:N63	4.12	Yes	No	0	6	9
46	R:R:I64	R:R:L92	2.85	No	Yes	0	4	6
47	R:R:F65	R:R:T69	2.59	No	No	0	7	8
48	R:R:F322	R:R:F65	6.43	No	No	0	7	7
49	R:R:I70	R:R:V66	3.07	No	No	0	7	9
50	R:R:A88	R:R:L67	3.15	No	No	0	9	8
51	R:R:I325	R:R:T69	4.56	No	No	0	6	8
52	R:R:I70	R:R:M318	2.92	No	Yes	0	7	8
53	R:R:I325	R:R:K72	7.27	No	No	0	6	6
54	R:R:F76	R:R:T73	6.49	Yes	No	0	8	6
55	R:R:H77	R:R:K74	11.79	No	No	0	7	6
56	R:R:E317	R:R:K75	5.4	No	No	0	7	6
57	R:R:F76	R:R:Y81	23.73	Yes	Yes	0	8	9
58	R:R:E317	R:R:F76	9.33	No	Yes	0	7	8
59	R:R:A321	R:R:F76	2.77	No	Yes	0	7	8
60	R:R:H77	R:R:Y82	3.27	No	No	0	7	4
61	R:R:P79	R:R:R78	2.88	No	Yes	0	7	7
62	R:R:M80	R:R:R78	7.44	No	Yes	0	8	7
63	R:R:R78	R:R:Y81	11.32	Yes	Yes	0	7	9
64	R:R:N153	R:R:R78	3.62	No	Yes	0	4	7
65	R:R:E141	R:R:M80	9.47	No	No	0	9	8
66	R:R:M80	R:R:R142	4.96	No	Yes	0	8	9
67	R:R:N315	R:R:Y81	4.65	No	Yes	3	8	9
68	R:R:M318	R:R:Y81	5.99	Yes	Yes	3	8	9
69	R:R:L160	R:R:Y82	4.69	No	No	0	7	4
70	R:R:A137	R:R:F83	2.77	No	Yes	2	7	8
71	R:R:F83	R:R:I138	3.77	Yes	Yes	2	8	8
72	R:R:E141	R:R:F83	8.16	No	Yes	0	9	8
73	R:R:F83	R:R:L160	7.31	Yes	No	0	8	7
74	R:R:F83	R:R:L163	4.87	Yes	No	2	8	6
75	R:R:N86	R:R:S134	7.45	No	No	0	9	8
76	R:R:I164	R:R:N86	5.66	No	No	0	7	9
77	R:R:N86	R:R:W168	6.78	No	No	0	9	9
78	R:R:D91	R:R:L87	4.07	Yes	Yes	0	9	9
79	R:R:L87	R:R:S134	7.51	Yes	No	0	9	8
80	R:R:L135	R:R:L87	9.69	No	Yes	0	9	9
81	R:R:I138	R:R:L87	2.85	Yes	Yes	0	8	9
82	R:R:A130	R:R:S90	3.42	No	No	0	7	8
83	R:R:S131	R:R:S90	3.26	No	No	0	9	8
84	R:R:D91	R:R:S131	8.83	Yes	No	0	9	9
85	R:R:D91	R:R:S304	11.78	Yes	No	0	9	9
86	R:R:D91	R:R:N307	2.69	Yes	No	0	9	9
87	R:R:L102	R:R:Y98	4.69	No	Yes	1	5	6
88	R:R:M124	R:R:Y98	3.59	Yes	Yes	1	6	6
89	R:R:L297	R:R:Y98	3.52	No	Yes	1	5	6
90	R:R:V298	R:R:Y98	6.31	No	Yes	1	5	6
91	R:R:N101	R:R:R120	18.08	No	Yes	0	5	6
92	R:R:M124	R:R:N101	7.01	Yes	No	0	6	5
93	R:R:L103	R:R:L104	4.15	No	No	0	6	4
94	R:R:G106	R:R:S105	3.71	No	No	0	4	4
95	R:R:R120	R:R:S105	7.91	Yes	No	0	6	4
96	R:R:T109	R:R:Y110	7.49	No	No	0	5	5
97	R:R:L112	R:R:Q116	3.99	No	No	0	5	4
98	R:R:L112	R:R:W117	4.56	No	Yes	1	5	9
99	R:R:L112	R:R:R120	3.64	No	Yes	1	5	6
100	R:R:P114	R:R:T113	6.99	No	No	0	3	7
101	R:R:F118	R:R:W117	4.01	Yes	Yes	1	6	9
102	R:R:R120	R:R:W117	6	Yes	Yes	1	6	9
103	R:R:E121	R:R:W117	16.36	Yes	Yes	1	5	9
104	R:R:L195	R:R:W117	4.56	Yes	Yes	1	3	9
105	R:R:L197	R:R:W117	6.83	Yes	Yes	1	4	9
106	R:R:W117	R:R:Y198	3.86	Yes	Yes	1	9	4
107	R:R:F118	R:R:N183	14.5	Yes	No	0	6	5
108	R:R:F118	R:R:L197	9.74	Yes	Yes	1	6	4
109	R:R:E121	R:R:L195	2.65	Yes	Yes	1	5	3
110	R:R:E121	R:R:Y198	5.61	Yes	Yes	1	5	4
111	R:R:L297	R:R:M124	2.83	No	Yes	1	5	6
112	R:R:F125	R:R:Y202	5.16	No	Yes	0	5	7
113	R:R:S171	R:R:V126	3.23	No	No	0	8	5
114	R:R:L172	R:R:V126	2.98	No	No	0	4	5
115	R:R:L128	R:R:W269	4.56	No	Yes	1	6	8
116	R:R:A130	R:R:W168	3.89	No	No	0	7	9
117	R:R:A130	R:R:S171	3.42	No	No	0	7	8
118	R:R:L213	R:R:V132	2.98	No	No	0	8	7
119	R:R:F133	R:R:I170	3.77	No	No	0	5	4
120	R:R:F133	R:R:L213	8.53	No	No	0	5	8
121	R:R:L135	R:R:N307	4.12	No	No	0	9	9
122	R:R:L135	R:R:Y311	3.52	No	Yes	0	9	9
123	R:R:I140	R:R:L136	5.71	No	No	0	6	7
124	R:R:L136	R:R:S216	3	No	No	0	7	6
125	R:R:I217	R:R:L136	4.28	No	No	0	8	7
126	R:R:A137	R:R:L163	3.15	No	No	2	7	6
127	R:R:I138	R:R:R142	3.76	Yes	Yes	2	8	9
128	R:R:I138	R:R:Y311	7.25	Yes	Yes	2	8	9
129	R:R:A139	R:R:Y221	5.34	No	Yes	0	8	9
130	R:R:I140	R:R:L220	2.85	No	No	0	6	7
131	R:R:R142	R:R:Y221	3.09	Yes	Yes	0	9	9
132	R:R:R142	R:R:Y311	5.14	Yes	Yes	2	9	9
133	R:R:L220	R:R:Y143	3.52	No	No	0	7	8
134	R:R:R223	R:R:Y143	10.29	No	No	0	5	8
135	R:R:I144	R:R:R159	8.77	No	Yes	0	4	5
136	R:R:M146	R:R:T145	3.01	Yes	No	0	8	8
137	R:R:I224	R:R:M146	5.83	No	Yes	0	9	8
138	R:R:M146	R:R:V228	3.04	Yes	No	0	8	8
139	R:R:K148	R:R:K150	10.06	No	No	0	6	7
140	R:R:M149	R:R:R231	11.17	No	Yes	0	8	7
141	R:R:N156	R:R:S155	5.96	No	No	2	7	7
142	R:R:R159	R:R:S155	2.64	Yes	No	2	5	7
143	R:R:F158	R:R:N156	3.62	No	No	0	4	7
144	R:R:N156	R:R:R159	3.62	No	Yes	2	7	5
145	R:R:F158	R:R:L162	3.65	No	No	0	4	3
146	R:R:I164	R:R:L160	4.28	No	No	0	7	7
147	R:R:C167	R:R:I164	3.27	No	No	0	6	7
148	R:R:G176	R:R:I179	3.53	No	No	0	4	5
149	R:R:L177	R:R:P178	3.28	No	No	0	5	5
150	R:R:P178	R:R:Y198	8.34	No	Yes	1	5	4
151	R:R:P178	R:R:Y202	11.13	No	Yes	1	5	7
152	R:R:I179	R:R:M180	5.83	No	No	0	5	4
153	R:R:I185	R:R:N183	8.5	No	No	0	3	5
154	R:R:C184	R:R:C191	7.28	No	No	0	5	9
155	R:R:H199	R:R:S190	9.76	No	No	0	4	4
156	R:R:S192	R:R:V194	4.85	No	Yes	1	4	4
157	R:R:I203	R:R:S192	3.1	Yes	No	1	6	4
158	R:R:D279	R:R:S192	4.42	Yes	No	1	4	4
159	R:R:L290	R:R:T193	5.9	Yes	No	0	3	5
160	R:R:L195	R:R:V194	4.47	Yes	Yes	1	3	4
161	R:R:D279	R:R:V194	4.38	Yes	Yes	1	4	4
162	R:R:L195	R:R:Y198	5.86	Yes	Yes	1	3	4
163	R:R:Y198	R:R:Y202	4.96	Yes	Yes	1	4	7
164	R:R:H199	R:R:H201	9.55	No	No	0	4	4
165	R:R:K200	R:R:V280	7.59	No	Yes	0	3	4
166	R:R:C206	R:R:Y202	9.41	No	Yes	0	6	7
167	R:R:I203	R:R:L276	4.28	Yes	Yes	1	6	6
168	R:R:D279	R:R:I203	2.8	Yes	Yes	1	4	6
169	R:R:I203	R:R:V280	3.07	Yes	Yes	1	6	4
170	R:R:L204	R:R:T207	4.42	No	Yes	0	5	5
171	R:R:F273	R:R:T207	5.19	Yes	Yes	0	6	5
172	R:R:L276	R:R:T207	4.42	Yes	Yes	0	6	5
173	R:R:F210	R:R:W269	9.02	No	Yes	1	7	8
174	R:R:F210	R:R:F273	6.43	No	Yes	0	7	6
175	R:R:F273	R:R:T211	5.19	Yes	No	0	6	4
176	R:R:F265	R:R:L214	3.65	No	No	0	9	5
177	R:R:I266	R:R:L214	5.71	No	No	0	6	5
178	R:R:V261	R:R:Y221	2.52	No	Yes	0	8	9
179	R:R:L262	R:R:Y221	5.86	No	Yes	0	7	9
180	R:R:R223	R:R:S226	2.64	No	No	0	5	3
181	R:R:R229	R:R:Y225	6.17	No	Yes	4	5	6
182	R:R:S251	R:R:Y225	2.54	No	Yes	4	7	6
183	R:R:L254	R:R:Y225	4.69	No	Yes	0	8	6
184	R:R:L255	R:R:Y225	7.03	No	Yes	0	8	6
185	R:R:L227	R:R:R231	3.64	No	Yes	0	6	7
186	R:R:L254	R:R:V228	4.47	No	No	0	8	8
187	R:R:R229	R:R:S251	2.64	No	No	4	5	7
188	R:R:R233	R:R:S251	2.64	No	No	0	4	7
189	R:R:L235	R:R:R234	6.07	No	No	0	6	4
190	R:R:L235	R:R:T236	5.9	No	No	0	6	4
191	R:R:K239	R:R:T236	4.5	No	No	0	2	4
192	R:R:F237	R:R:R238	8.55	No	No	0	3	5
193	R:R:I241	R:R:K239	4.36	No	No	0	2	2
194	R:R:E249	R:R:S248	5.75	No	No	0	5	4
195	R:R:I259	R:R:L255	2.85	No	No	0	5	8
196	R:R:T257	R:R:T314	4.71	No	No	0	9	7
197	R:R:V261	R:R:Y311	2.52	No	Yes	0	8	9
198	R:R:I310	R:R:V264	4.61	No	No	0	8	7
199	R:R:F265	R:R:W269	5.01	No	Yes	0	9	8
200	R:R:C268	R:R:N303	12.6	No	No	0	8	9
201	R:R:N303	R:R:W269	7.91	No	Yes	0	9	8
202	R:R:F296	R:R:P271	5.78	No	No	0	4	9
203	R:R:L299	R:R:P271	3.28	No	No	0	7	9
204	R:R:L272	R:R:L276	2.77	No	Yes	1	6	6
205	R:R:F273	R:R:L277	3.65	Yes	No	0	6	6
206	R:R:I274	R:R:L277	4.28	No	No	0	5	6
207	R:R:L275	R:R:L290	2.77	No	Yes	0	4	3
208	R:R:F296	R:R:L275	9.74	No	No	0	4	4
209	R:R:D279	R:R:L276	4.07	Yes	Yes	1	4	6
210	R:R:D279	R:R:V280	2.92	Yes	Yes	1	4	4
211	R:R:D279	R:R:L290	4.07	Yes	Yes	1	4	3
212	R:R:G281	R:R:V280	3.68	No	Yes	0	4	4
213	R:R:C282	R:R:C287	7.28	No	No	1	4	3
214	R:R:C282	R:R:L290	3.17	No	Yes	1	4	3
215	R:R:K285	R:R:V284	3.04	No	No	0	2	1
216	R:R:C287	R:R:L290	6.35	No	Yes	1	3	3
217	R:R:E294	R:R:Y295	17.96	No	No	0	3	3
218	R:R:S304	R:R:V301	3.23	No	No	0	9	7
219	R:R:N303	R:R:N307	5.45	No	No	0	9	9
220	R:R:I309	R:R:L313	4.28	No	No	0	6	6
221	R:R:M318	R:R:T312	12.04	Yes	No	0	8	7
222	R:R:N315	R:R:T314	2.92	No	No	0	8	7
223	R:R:M318	R:R:N315	7.01	Yes	No	3	8	8
224	R:R:F322	R:R:I323	5.02	No	No	0	7	3
225	R:R:F118	R:R:I179	2.51	Yes	No	0	6	5
226	R:R:M146	R:R:R231	2.48	Yes	Yes	0	8	7
227	R:R:F205	R:R:L174	2.44	No	No	0	5	5
228	R:R:L163	R:R:R159	2.43	No	Yes	2	6	5
229	R:R:I84	R:R:Y81	2.42	No	Yes	0	8	9
230	R:R:F161	R:R:N157	2.42	No	No	0	2	1
231	R:R:I217	R:R:Y221	2.42	No	Yes	0	8	9
232	R:R:D288	R:R:F291	2.39	No	No	0	3	1
233	R:R:L147	R:R:Y143	2.34	No	No	0	6	8
234	R:R:E317	R:R:R320	2.33	No	No	0	7	5
235	R:R:L93	R:R:W168	2.28	No	No	0	6	9
236	R:R:L177	R:R:W182	2.28	No	No	0	5	5
237	R:R:G175	R:R:G176	2.11	No	No	0	6	4
238	R:R:G305	R:R:P308	2.03	No	No	0	7	9
239	R:R:A88	R:R:G85	1.95	No	No	0	9	5
240	R:R:A94	R:R:G95	1.95	No	No	0	8	7
241	R:R:A270	R:R:P271	1.87	No	No	0	6	9
242	R:R:G305	R:R:S304	1.86	No	No	0	7	9
243	R:R:G33	R:R:T32	1.82	No	No	0	7	8
244	R:R:A127	R:R:A94	1.79	No	No	0	6	8
245	R:R:G85	R:R:I70	1.76	No	No	0	5	7
246	R:R:P196	R:R:T32	1.75	No	No	0	3	8
247	R:R:G181	R:R:M180	1.75	No	No	0	5	4
248	R:R:C184	R:R:S190	1.72	No	No	0	5	4
249	R:R:A187	R:R:S190	1.71	No	No	0	4	4
250	R:R:C222	R:R:V218	1.71	No	No	0	3	4
251	R:R:A127	R:R:V126	1.7	No	No	0	6	5
252	R:R:G154	R:R:N153	1.7	No	No	0	4	4
253	R:R:A293	R:R:V194	1.7	No	Yes	0	4	4
254	R:R:C282	R:R:T286	1.69	No	No	0	4	1
255	R:R:A115	R:R:T113	1.68	No	No	0	2	7
256	R:R:C57	R:R:I53	1.64	No	No	0	5	3
257	R:R:N157	R:R:P79	1.63	No	No	0	1	7
258	R:R:S232	R:R:T236	1.6	No	No	0	5	4
259	R:R:T306	R:R:V264	1.59	No	No	0	5	7
260	R:R:A100	R:R:L104	1.58	No	No	0	7	4
261	R:R:A300	R:R:L272	1.58	No	No	0	7	6
262	R:R:T207	R:R:T208	1.57	Yes	No	0	5	4
263	R:R:I185	R:R:S186	1.55	No	No	0	3	1
264	R:R:I259	R:R:S263	1.55	No	No	0	5	5
265	R:R:I55	R:R:V51	1.54	No	No	0	6	5
266	R:R:I55	R:R:V298	1.54	No	No	0	6	5
267	R:R:I170	R:R:V169	1.54	No	No	0	4	4
268	R:R:I266	R:R:V218	1.54	No	No	0	6	4
269	R:R:I260	R:R:V261	1.54	No	No	0	6	8
270	R:R:I309	R:R:T306	1.52	No	No	0	6	5
271	R:R:I310	R:R:T314	1.52	No	No	0	8	7
272	R:R:L102	R:R:S49	1.5	No	No	0	5	5
273	R:R:K72	R:R:T73	1.5	No	No	0	6	6
274	R:R:K283	R:R:T286	1.5	No	No	0	1	1
275	R:R:L262	R:R:V258	1.49	No	No	0	7	8
276	R:R:L68	R:R:T69	1.47	No	No	0	4	8
277	R:R:L103	R:R:T99	1.47	No	No	0	6	6
278	R:R:L212	R:R:T208	1.47	No	No	0	5	4
279	R:R:L215	R:R:T211	1.47	No	No	0	4	4
280	R:R:G122	R:R:Y198	1.45	No	Yes	0	6	4
281	R:R:F118	R:R:P114	1.44	Yes	No	0	6	3
282	R:R:I25	R:R:L197	1.43	No	Yes	0	4	4
283	R:R:I59	R:R:L302	1.43	No	No	0	7	6
284	R:R:I64	R:R:L61	1.43	No	No	0	4	4
285	R:R:I170	R:R:L174	1.43	No	No	0	4	5
286	R:R:I289	R:R:L278	1.43	No	No	0	3	4
287	R:R:P114	R:R:Y22	1.39	No	No	0	3	5
288	R:R:L89	R:R:L92	1.38	No	Yes	0	5	6
289	R:R:L147	R:R:L227	1.38	No	No	0	6	6
290	R:R:L278	R:R:L290	1.38	No	Yes	0	4	3
291	R:R:R120	R:R:S123	1.32	Yes	No	0	6	4
292	R:R:F291	R:R:T193	1.3	No	No	0	1	5
293	R:R:R324	R:R:T73	1.29	No	No	0	4	6
294	R:R:H152	R:R:L151	1.29	No	No	0	7	4
295	R:R:R231	R:R:T230	1.29	Yes	No	0	7	5
296	R:R:K316	R:R:R319	1.24	No	No	0	6	8
297	R:R:L313	R:R:R319	1.21	No	No	0	6	8
298	R:R:D23	R:R:R27	1.19	No	No	0	7	3
299	R:R:D288	R:R:R292	1.19	No	No	0	3	4
300	R:R:L35	R:R:Y29	1.17	No	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.54267	15	1	0
2	R:R:H28	5.53167	6	0	8
3	R:R:Y29	4.06	6	1	7
4	R:R:F52	7.095	4	1	6
5	R:R:F76	10.58	4	0	8
6	R:R:R78	6.315	4	0	7
7	R:R:Y81	9.622	5	3	9
8	R:R:F83	5.376	5	2	8
9	R:R:L87	6.03	4	0	9
10	R:R:D91	6.8425	4	0	9
11	R:R:L92	3.1575	4	0	6
12	R:R:Y98	4.775	6	1	6
13	R:R:W117	6.13375	8	1	9
14	R:R:F118	6.44	5	1	6
15	R:R:R120	7.39	5	1	6
16	R:R:E121	8.3475	4	1	5
17	R:R:M124	4.2925	4	1	6
18	R:R:I138	4.4075	4	2	8
19	R:R:R142	4.2375	4	2	9
20	R:R:M146	3.59	4	0	8
21	R:R:R159	4.365	4	2	5
22	R:R:V194	3.85	4	1	4
23	R:R:L195	5.158	5	1	3
24	R:R:L197	6.1075	4	1	4
25	R:R:Y198	5.01333	6	1	4
26	R:R:Y202	7.665	4	1	7
27	R:R:I203	3.3125	4	1	6
28	R:R:T207	3.9	4	0	5
29	R:R:Y221	3.846	5	0	9
30	R:R:Y225	5.1075	4	4	6
31	R:R:R231	4.645	4	0	7
32	R:R:W269	6.206	5	1	8
33	R:R:F273	5.115	4	0	6
34	R:R:L276	4.942	5	1	6
35	R:R:D279	3.77667	6	1	4
36	R:R:V280	4.315	4	1	4
37	R:R:L290	3.94	6	1	3
38	R:R:Y311	4.6075	4	2	9
39	R:R:M318	6.99	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y29	29.747	6.21	Yes	Yes	1	0	7
2	R:R:P196	R:R:Y29	13.1488	5.56	No	Yes	0	3	7
3	R:R:H28	R:R:P196	10.9139	6.1	Yes	No	0	8	3
4	R:R:W117	R:R:Y29	14.2134	2.89	Yes	Yes	1	9	7
5	L:L:?1	R:R:M124	17.9529	3.74	Yes	Yes	1	0	6
6	R:R:M124	R:R:Y98	15.2952	3.59	Yes	Yes	1	6	6
7	L:L:?1	R:R:L297	15.1476	8.25	Yes	No	1	0	5
8	R:R:L297	R:R:Y98	14.3338	3.52	No	Yes	1	5	6
9	R:R:C56	R:R:Y98	12.3718	5.38	No	Yes	0	5	6
10	R:R:C56	R:R:T99	10.6188	3.38	No	No	0	5	6
11	L:L:?1	R:R:W269	94.8098	4.53	Yes	Yes	1	0	8
12	R:R:N303	R:R:W269	100	7.91	No	Yes	0	9	8
13	R:R:N303	R:R:N307	99.8967	5.45	No	No	0	9	9
14	R:R:L135	R:R:N307	75.2637	4.12	No	No	0	9	9
15	R:R:L135	R:R:Y311	63.6491	3.52	No	Yes	0	9	9
16	R:R:R142	R:R:Y311	38.7751	5.14	Yes	Yes	2	9	9
17	R:R:M80	R:R:R142	29.9609	4.96	No	Yes	0	8	9
18	R:R:M80	R:R:R78	31.4041	7.44	No	Yes	0	8	7
19	R:R:R78	R:R:Y81	27.2761	11.32	Yes	Yes	0	7	9
20	R:R:D91	R:R:N307	25.024	2.69	Yes	No	0	9	9
21	R:R:D91	R:R:S304	10.609	11.78	Yes	No	0	9	9
22	R:R:F76	R:R:Y81	11.6023	23.73	Yes	Yes	0	8	9
23	R:R:D91	R:R:L87	16.9228	4.07	Yes	Yes	0	9	9
24	R:R:I138	R:R:L87	22.9415	2.85	Yes	Yes	0	8	9
25	R:R:F83	R:R:I138	23.9938	3.77	Yes	Yes	2	8	8
26	R:R:L135	R:R:L87	11.9662	9.69	No	Yes	0	9	9
27	R:R:F83	R:R:L163	12.9201	4.87	Yes	No	2	8	6
28	L:L:?1	R:R:E121	17.3358	8.77	Yes	Yes	1	0	5
29	R:R:E121	R:R:W117	13.5889	16.36	Yes	Yes	1	5	9
30	L:L:?1	R:R:L195	19.1749	8.25	Yes	Yes	1	0	3
31	R:R:L195	R:R:W117	15.8213	4.56	Yes	Yes	1	3	9
32	R:R:F118	R:R:W117	27.1409	4.01	Yes	Yes	1	6	9
33	R:R:R142	R:R:Y221	22.3367	3.09	Yes	Yes	0	9	9
34	R:R:I217	R:R:Y221	32.6703	2.42	No	Yes	0	8	9
35	R:R:I217	R:R:L136	31.414	4.28	No	No	0	8	7
36	R:R:I140	R:R:L136	28.8865	5.71	No	No	0	6	7
37	R:R:V261	R:R:Y311	17.2055	2.52	No	Yes	0	8	9
38	R:R:V261	R:R:Y221	15.7402	2.52	No	Yes	0	8	9
39	R:R:I140	R:R:L220	27.6154	2.85	No	No	0	6	7
40	R:R:L220	R:R:Y143	26.3393	3.52	No	No	0	7	8
41	R:R:L163	R:R:R159	11.0835	2.43	No	Yes	2	6	5
42	R:R:L147	R:R:Y143	22.4817	2.34	No	No	0	6	8
43	R:R:L147	R:R:L227	21.1811	1.38	No	No	0	6	6
44	R:R:L227	R:R:R231	19.9862	3.64	No	Yes	0	6	7
45	R:R:M146	R:R:R231	16.05	2.48	Yes	Yes	0	8	7
46	R:R:M146	R:R:V228	12.0743	3.04	Yes	No	0	8	8
47	R:R:F118	R:R:I179	10.8278	2.51	Yes	No	0	6	5
48	L:L:?1	R:R:L276	22.0859	9.17	Yes	Yes	1	0	6
49	R:R:D279	R:R:L276	14.8821	4.07	Yes	Yes	1	4	6
50	R:R:D279	R:R:L290	13.4512	4.07	Yes	Yes	1	4	3
51	R:R:L254	R:R:V228	10.7418	4.47	No	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y29	6.21	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:K34	8.4	1	Yes	No	0	6	0	1
L:L:?1	R:R:E121	8.77	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M124	3.74	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F125	16.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:L128	5.5	1	Yes	No	0	6	0	1
L:L:?1	R:R:S129	7.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:V132	3.95	1	Yes	No	0	7	0	1
L:L:?1	R:R:L195	8.25	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:V209	2.96	1	Yes	No	0	5	0	1
L:L:?1	R:R:F210	12.1	1	Yes	No	0	7	0	1
L:L:?1	R:R:W269	4.53	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L272	6.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:L276	9.17	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L297	8.25	1	Yes	No	0	5	0	1
R:R:K34	R:R:Y29	4.78	1	No	Yes	6	7	1	1
R:R:T109	R:R:Y29	3.75	0	No	Yes	5	7	2	1
R:R:W117	R:R:Y29	2.89	1	Yes	Yes	9	7	2	1
R:R:P196	R:R:Y29	5.56	0	No	Yes	3	7	2	1
R:R:M124	R:R:Y98	3.59	1	Yes	Yes	6	6	1	2
R:R:L297	R:R:Y98	3.52	1	No	Yes	5	6	1	2
R:R:M124	R:R:N101	7.01	1	Yes	No	6	5	1	2
R:R:E121	R:R:W117	16.36	1	Yes	Yes	5	9	1	2
R:R:L195	R:R:W117	4.56	1	Yes	Yes	3	9	1	2
R:R:W117	R:R:Y198	3.86	1	Yes	Yes	9	4	2	2
R:R:E121	R:R:L195	2.65	1	Yes	Yes	5	3	1	1
R:R:E121	R:R:Y198	5.61	1	Yes	Yes	5	4	1	2
R:R:L297	R:R:M124	2.83	1	No	Yes	5	6	1	1
R:R:F125	R:R:Y202	5.16	0	No	Yes	5	7	1	2
R:R:L128	R:R:W269	4.56	1	No	Yes	6	8	1	1
R:R:L213	R:R:V132	2.98	0	No	No	8	7	2	1
R:R:L195	R:R:V194	4.47	1	Yes	Yes	3	4	1	2
R:R:D279	R:R:V194	4.38	1	Yes	Yes	4	4	2	2
R:R:L195	R:R:Y198	5.86	1	Yes	Yes	3	4	1	2
R:R:Y198	R:R:Y202	4.96	1	Yes	Yes	4	7	2	2
R:R:I203	R:R:L276	4.28	1	Yes	Yes	6	6	2	1
R:R:D279	R:R:I203	2.8	1	Yes	Yes	4	6	2	2
R:R:F273	R:R:T207	5.19	0	Yes	Yes	6	5	2	2
R:R:L276	R:R:T207	4.42	1	Yes	Yes	6	5	1	2
R:R:F210	R:R:W269	9.02	1	No	Yes	7	8	1	1
R:R:F210	R:R:F273	6.43	1	No	Yes	7	6	1	2
R:R:F265	R:R:W269	5.01	0	No	Yes	9	8	2	1
R:R:N303	R:R:W269	7.91	0	No	Yes	9	8	2	1
R:R:L272	R:R:L276	2.77	1	No	Yes	6	6	1	1
R:R:D279	R:R:L276	4.07	1	Yes	Yes	4	6	2	1
R:R:A300	R:R:L272	1.58	0	No	No	7	6	2	1
R:R:L35	R:R:Y29	1.17	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EVY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.52
Number of Linked Nodes	268
Number of Links	300
Number of Hubs	39
Number of Links mediated by Hubs	149
Number of Communities	4
Number of Nodes involved in Communities	47
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	52
Number Of Links MetaPath	51
Number of Shortest Paths	64183
Length Of Smallest Path	3
Average Path Length	13.6003
Length of Longest Path	31
Minimum Path Strength	1.225
Average Path Strength	5.23544
Maximum Path Strength	17.525
Minimum Path Correlation	0.7
Average Path Correlation	0.937109
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	56.4578
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.1209
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • sphingolipid binding • lipid binding • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • signaling receptor binding • G protein-coupled receptor binding • hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • head development • central nervous system development • brain development • nervous system development • cell adhesion • regulation of cell adhesion • lamellipodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component organization • cellular component biogenesis • cellular component assembly • lamellipodium organization • cellular component organization or biogenesis • cell projection assembly • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • negative regulation of biological process • regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • negative regulation of cellular process • stress fiber assembly • negative regulation of supramolecular fiber organization • regulation of actin filament organization • negative regulation of stress fiber assembly • actin cytoskeleton organization • actomyosin structure organization • negative regulation of cellular component organization • negative regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • negative regulation of actin filament bundle assembly • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • negative regulation of organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • heart trabecula morphogenesis • trabecula morphogenesis • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • cellular developmental process • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • homeostatic process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • regulation of multicellular organismal process • regulation of multicellular organismal development • regulation of developmental process • bone mineralization • regulation of biomineral tissue development • regulation of bone mineralization • ossification • biomineral tissue development • regulation of ossification • chemotaxis • taxis • response to external stimulus • locomotion • metabolic process • regulation of metabolic process • positive chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • regulation of response to stimulus • regulation of locomotion • transmission of nerve impulse • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • positive regulation of cellular process • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • developmental growth • heart morphogenesis • organ growth • striated muscle tissue development • muscle structure development • cardiac muscle tissue growth involved in heart morphogenesis • animal organ morphogenesis • cardiac muscle tissue growth • muscle tissue development • muscle organ development • heart development • heart growth • cardiac muscle tissue development • growth • muscle tissue morphogenesis • developmental growth involved in morphogenesis • tissue morphogenesis • cardiac muscle tissue morphogenesis • growth involved in heart morphogenesis • muscle organ morphogenesis • cell chemotaxis • leukocyte chemotaxis • sphingolipid mediated signaling pathway • sphingosine-1-phosphate receptor signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • blood vessel maturation • developmental maturation • anatomical structure maturation • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to stress • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • cell surface • external side of plasma membrane • membrane microdomain • membrane raft • presynapse • endosome • intracellular vesicle • cytoplasmic vesicle • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J8C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J8C
Name	Siponimod
Synonyms	Siponimod fumarate Siponimod
Identifier
Formula	C29 H35 F3 N2 O3
Molecular Weight	516.595
SMILES
PubChem	72959169
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	75
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7EVY_nogp_Chain_R Y D I I V R H Y N Y T G K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R K N I S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	10.7554/eLife.88204
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	10.1073/pnas.2117716119
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	10.1073/pnas.2117716119
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	10.1038/s41467-022-28417-2
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	10.1038/s41422-021-00566-x
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	10.1126/science.1215904
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	10.1126/science.1215904

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