psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?1	R:R:N30	20.95	No	No	0	0	9
2	L:L:?1	R:R:Y29	6.21	Yes	Yes	1	0	7
3	L:L:?1	R:R:K34	8.4	Yes	No	1	0	6
4	L:L:?1	R:R:E121	8.77	Yes	Yes	1	0	5
5	L:L:?1	R:R:M124	3.74	Yes	Yes	1	0	6
6	L:L:?1	R:R:F125	16.94	Yes	No	0	0	5
7	L:L:?1	R:R:L128	5.5	Yes	No	1	0	6
8	L:L:?1	R:R:S129	7.95	Yes	No	0	0	6
9	L:L:?1	R:R:V132	3.95	Yes	No	0	0	7
10	L:L:?1	R:R:L195	8.25	Yes	Yes	1	0	3
11	L:L:?1	R:R:V209	2.96	Yes	No	0	0	5
12	L:L:?1	R:R:F210	12.1	Yes	No	1	0	7
13	L:L:?1	R:R:W269	4.53	Yes	Yes	1	0	8
14	L:L:?1	R:R:L272	6.42	Yes	No	1	0	6
15	L:L:?1	R:R:L276	9.17	Yes	Yes	1	0	6
16	L:L:?1	R:R:L297	8.25	Yes	No	1	0	5
17	R:R:D23	R:R:V26	4.38	No	No	0	7	6
18	R:R:H28	R:R:I24	5.3	Yes	No	0	8	4
19	R:R:H28	R:R:R27	4.51	Yes	No	0	8	3
20	R:R:H28	R:R:L188	6.43	Yes	No	0	8	2
21	R:R:C191	R:R:H28	4.42	No	Yes	0	9	8
22	R:R:H28	R:R:P196	6.1	Yes	No	0	8	3
23	R:R:H28	R:R:L197	6.43	Yes	Yes	0	8	4
24	R:R:K34	R:R:Y29	4.78	No	Yes	1	6	7
25	R:R:T109	R:R:Y29	3.75	No	Yes	0	5	7
26	R:R:W117	R:R:Y29	2.89	Yes	Yes	1	9	7
27	R:R:P196	R:R:Y29	5.56	No	Yes	0	3	7
28	R:R:L35	R:R:N30	2.75	No	No	0	6	9
29	R:R:L188	R:R:Y31	19.93	No	No	0	2	5
30	R:R:V284	R:R:Y31	2.52	No	No	0	1	5
31	R:R:S49	R:R:T48	3.2	No	No	0	5	5
32	R:R:T48	R:R:Y295	3.75	No	No	0	5	3
33	R:R:F52	R:R:V51	2.62	Yes	No	0	6	5
34	R:R:F52	R:R:Y98	5.16	Yes	Yes	1	6	6
35	R:R:F52	R:R:L102	4.87	Yes	No	1	6	5
36	R:R:F52	R:R:V298	15.73	Yes	No	1	6	5
37	R:R:I53	R:R:T99	4.56	No	No	0	3	6
38	R:R:C56	R:R:Y98	5.38	No	Yes	0	5	6
39	R:R:C56	R:R:T99	3.38	No	No	0	5	6
40	R:R:E62	R:R:F58	17.49	No	No	0	8	4
41	R:R:I59	R:R:N63	4.25	No	No	0	7	9
42	R:R:G305	R:R:I59	7.05	No	No	0	7	7
43	R:R:I60	R:R:L92	4.28	No	Yes	0	6	6
44	R:R:I60	R:R:V96	3.07	No	No	0	6	5
45	R:R:E62	R:R:I309	6.83	No	No	0	8	6
46	R:R:L92	R:R:N63	4.12	Yes	No	0	6	9
47	R:R:I64	R:R:L92	2.85	No	Yes	0	4	6
48	R:R:F65	R:R:T69	2.59	No	No	0	7	8
49	R:R:F322	R:R:F65	6.43	No	No	0	7	7
50	R:R:I70	R:R:V66	3.07	No	No	0	7	9
51	R:R:A88	R:R:L67	3.15	No	No	0	9	8
52	R:R:I325	R:R:T69	4.56	No	No	0	6	8
53	R:R:I70	R:R:M318	2.92	No	Yes	0	7	8
54	R:R:I325	R:R:K72	7.27	No	No	0	6	6
55	R:R:F76	R:R:T73	6.49	Yes	No	0	8	6
56	R:R:H77	R:R:K74	11.79	No	No	0	7	6
57	R:R:E317	R:R:K75	5.4	No	No	0	7	6
58	R:R:F76	R:R:Y81	23.73	Yes	Yes	0	8	9
59	R:R:E317	R:R:F76	9.33	No	Yes	0	7	8
60	R:R:A321	R:R:F76	2.77	No	Yes	0	7	8
61	R:R:H77	R:R:Y82	3.27	No	No	0	7	4
62	R:R:P79	R:R:R78	2.88	No	Yes	0	7	7
63	R:R:M80	R:R:R78	7.44	No	Yes	0	8	7
64	R:R:R78	R:R:Y81	11.32	Yes	Yes	0	7	9
65	R:R:N153	R:R:R78	3.62	No	Yes	0	4	7
66	R:R:E141	R:R:M80	9.47	No	No	0	9	8
67	R:R:M80	R:R:R142	4.96	No	Yes	0	8	9
68	R:R:N315	R:R:Y81	4.65	No	Yes	3	8	9
69	R:R:M318	R:R:Y81	5.99	Yes	Yes	3	8	9
70	R:R:L160	R:R:Y82	4.69	No	No	0	7	4
71	R:R:A137	R:R:F83	2.77	No	Yes	2	7	8
72	R:R:F83	R:R:I138	3.77	Yes	Yes	2	8	8
73	R:R:E141	R:R:F83	8.16	No	Yes	0	9	8
74	R:R:F83	R:R:L160	7.31	Yes	No	0	8	7
75	R:R:F83	R:R:L163	4.87	Yes	No	2	8	6
76	R:R:N86	R:R:S134	7.45	No	No	0	9	8
77	R:R:I164	R:R:N86	5.66	No	No	0	7	9
78	R:R:N86	R:R:W168	6.78	No	No	0	9	9
79	R:R:D91	R:R:L87	4.07	Yes	Yes	0	9	9
80	R:R:L87	R:R:S134	7.51	Yes	No	0	9	8
81	R:R:L135	R:R:L87	9.69	No	Yes	0	9	9
82	R:R:I138	R:R:L87	2.85	Yes	Yes	0	8	9
83	R:R:A130	R:R:S90	3.42	No	No	0	7	8
84	R:R:S131	R:R:S90	3.26	No	No	0	9	8
85	R:R:D91	R:R:S131	8.83	Yes	No	0	9	9
86	R:R:D91	R:R:S304	11.78	Yes	No	0	9	9
87	R:R:D91	R:R:N307	2.69	Yes	No	0	9	9
88	R:R:L102	R:R:Y98	4.69	No	Yes	1	5	6
89	R:R:M124	R:R:Y98	3.59	Yes	Yes	1	6	6
90	R:R:L297	R:R:Y98	3.52	No	Yes	1	5	6
91	R:R:V298	R:R:Y98	6.31	No	Yes	1	5	6
92	R:R:N101	R:R:R120	18.08	No	Yes	0	5	6
93	R:R:M124	R:R:N101	7.01	Yes	No	0	6	5
94	R:R:L103	R:R:L104	4.15	No	No	0	6	4
95	R:R:G106	R:R:S105	3.71	No	No	0	4	4
96	R:R:R120	R:R:S105	7.91	Yes	No	0	6	4
97	R:R:T109	R:R:Y110	7.49	No	No	0	5	5
98	R:R:L112	R:R:Q116	3.99	No	No	0	5	4
99	R:R:L112	R:R:W117	4.56	No	Yes	1	5	9
100	R:R:L112	R:R:R120	3.64	No	Yes	1	5	6
101	R:R:P114	R:R:T113	6.99	No	No	0	3	7
102	R:R:F118	R:R:W117	4.01	Yes	Yes	1	6	9
103	R:R:R120	R:R:W117	6	Yes	Yes	1	6	9
104	R:R:E121	R:R:W117	16.36	Yes	Yes	1	5	9
105	R:R:L195	R:R:W117	4.56	Yes	Yes	1	3	9
106	R:R:L197	R:R:W117	6.83	Yes	Yes	1	4	9
107	R:R:W117	R:R:Y198	3.86	Yes	Yes	1	9	4
108	R:R:F118	R:R:N183	14.5	Yes	No	0	6	5
109	R:R:F118	R:R:L197	9.74	Yes	Yes	1	6	4
110	R:R:E121	R:R:L195	2.65	Yes	Yes	1	5	3
111	R:R:E121	R:R:Y198	5.61	Yes	Yes	1	5	4
112	R:R:L297	R:R:M124	2.83	No	Yes	1	5	6
113	R:R:F125	R:R:Y202	5.16	No	Yes	0	5	7
114	R:R:S171	R:R:V126	3.23	No	No	0	8	5
115	R:R:L172	R:R:V126	2.98	No	No	0	4	5
116	R:R:L128	R:R:W269	4.56	No	Yes	1	6	8
117	R:R:A130	R:R:W168	3.89	No	No	0	7	9
118	R:R:A130	R:R:S171	3.42	No	No	0	7	8
119	R:R:L213	R:R:V132	2.98	No	No	0	8	7
120	R:R:F133	R:R:I170	3.77	No	No	0	5	4
121	R:R:F133	R:R:L213	8.53	No	No	0	5	8
122	R:R:L135	R:R:N307	4.12	No	No	0	9	9
123	R:R:L135	R:R:Y311	3.52	No	Yes	0	9	9
124	R:R:I140	R:R:L136	5.71	No	No	0	6	7
125	R:R:L136	R:R:S216	3	No	No	0	7	6
126	R:R:I217	R:R:L136	4.28	No	No	0	8	7
127	R:R:A137	R:R:L163	3.15	No	No	2	7	6
128	R:R:I138	R:R:R142	3.76	Yes	Yes	2	8	9
129	R:R:I138	R:R:Y311	7.25	Yes	Yes	2	8	9
130	R:R:A139	R:R:Y221	5.34	No	Yes	0	8	9
131	R:R:I140	R:R:L220	2.85	No	No	0	6	7
132	R:R:R142	R:R:Y221	3.09	Yes	Yes	0	9	9
133	R:R:R142	R:R:Y311	5.14	Yes	Yes	2	9	9
134	R:R:L220	R:R:Y143	3.52	No	No	0	7	8
135	R:R:R223	R:R:Y143	10.29	No	No	0	5	8
136	R:R:I144	R:R:R159	8.77	No	Yes	0	4	5
137	R:R:M146	R:R:T145	3.01	Yes	No	0	8	8
138	R:R:I224	R:R:M146	5.83	No	Yes	0	9	8
139	R:R:M146	R:R:V228	3.04	Yes	No	0	8	8
140	R:R:K148	R:R:K150	10.06	No	No	0	6	7
141	R:R:M149	R:R:R231	11.17	No	Yes	0	8	7
142	R:R:N156	R:R:S155	5.96	No	No	2	7	7
143	R:R:R159	R:R:S155	2.64	Yes	No	2	5	7
144	R:R:F158	R:R:N156	3.62	No	No	0	4	7
145	R:R:N156	R:R:R159	3.62	No	Yes	2	7	5
146	R:R:F158	R:R:L162	3.65	No	No	0	4	3
147	R:R:I164	R:R:L160	4.28	No	No	0	7	7
148	R:R:C167	R:R:I164	3.27	No	No	0	6	7
149	R:R:G176	R:R:I179	3.53	No	No	0	4	5
150	R:R:L177	R:R:P178	3.28	No	No	0	5	5
151	R:R:P178	R:R:Y198	8.34	No	Yes	1	5	4
152	R:R:P178	R:R:Y202	11.13	No	Yes	1	5	7
153	R:R:I179	R:R:M180	5.83	No	No	0	5	4
154	R:R:I185	R:R:N183	8.5	No	No	0	3	5
155	R:R:C184	R:R:C191	7.28	No	No	0	5	9
156	R:R:H199	R:R:S190	9.76	No	No	0	4	4
157	R:R:S192	R:R:V194	4.85	No	Yes	1	4	4
158	R:R:I203	R:R:S192	3.1	Yes	No	1	6	4
159	R:R:D279	R:R:S192	4.42	Yes	No	1	4	4
160	R:R:L290	R:R:T193	5.9	Yes	No	0	3	5
161	R:R:L195	R:R:V194	4.47	Yes	Yes	1	3	4
162	R:R:D279	R:R:V194	4.38	Yes	Yes	1	4	4
163	R:R:L195	R:R:Y198	5.86	Yes	Yes	1	3	4
164	R:R:Y198	R:R:Y202	4.96	Yes	Yes	1	4	7
165	R:R:H199	R:R:H201	9.55	No	No	0	4	4
166	R:R:K200	R:R:V280	7.59	No	Yes	0	3	4
167	R:R:C206	R:R:Y202	9.41	No	Yes	0	6	7
168	R:R:I203	R:R:L276	4.28	Yes	Yes	1	6	6
169	R:R:D279	R:R:I203	2.8	Yes	Yes	1	4	6
170	R:R:I203	R:R:V280	3.07	Yes	Yes	1	6	4
171	R:R:L204	R:R:T207	4.42	No	Yes	0	5	5
172	R:R:F273	R:R:T207	5.19	Yes	Yes	0	6	5
173	R:R:L276	R:R:T207	4.42	Yes	Yes	0	6	5
174	R:R:F210	R:R:W269	9.02	No	Yes	1	7	8
175	R:R:F210	R:R:F273	6.43	No	Yes	0	7	6
176	R:R:F273	R:R:T211	5.19	Yes	No	0	6	4
177	R:R:F265	R:R:L214	3.65	No	No	0	9	5
178	R:R:I266	R:R:L214	5.71	No	No	0	6	5
179	R:R:V261	R:R:Y221	2.52	No	Yes	0	8	9
180	R:R:L262	R:R:Y221	5.86	No	Yes	0	7	9
181	R:R:R223	R:R:S226	2.64	No	No	0	5	3
182	R:R:R229	R:R:Y225	6.17	No	Yes	4	5	6
183	R:R:S251	R:R:Y225	2.54	No	Yes	4	7	6
184	R:R:L254	R:R:Y225	4.69	No	Yes	0	8	6
185	R:R:L255	R:R:Y225	7.03	No	Yes	0	8	6
186	R:R:L227	R:R:R231	3.64	No	Yes	0	6	7
187	R:R:L254	R:R:V228	4.47	No	No	0	8	8
188	R:R:R229	R:R:S251	2.64	No	No	4	5	7
189	R:R:R233	R:R:S251	2.64	No	No	0	4	7
190	R:R:L235	R:R:R234	6.07	No	No	0	6	4
191	R:R:L235	R:R:T236	5.9	No	No	0	6	4
192	R:R:K239	R:R:T236	4.5	No	No	0	2	4
193	R:R:F237	R:R:R238	8.55	No	No	0	3	5
194	R:R:I241	R:R:K239	4.36	No	No	0	2	2
195	R:R:E249	R:R:S248	5.75	No	No	0	5	4
196	R:R:I259	R:R:L255	2.85	No	No	0	5	8
197	R:R:T257	R:R:T314	4.71	No	No	0	9	7
198	R:R:V261	R:R:Y311	2.52	No	Yes	0	8	9
199	R:R:I310	R:R:V264	4.61	No	No	0	8	7
200	R:R:F265	R:R:W269	5.01	No	Yes	0	9	8
201	R:R:C268	R:R:N303	12.6	No	No	0	8	9
202	R:R:N303	R:R:W269	7.91	No	Yes	0	9	8
203	R:R:F296	R:R:P271	5.78	No	No	0	4	9
204	R:R:L299	R:R:P271	3.28	No	No	0	7	9
205	R:R:L272	R:R:L276	2.77	No	Yes	1	6	6
206	R:R:F273	R:R:L277	3.65	Yes	No	0	6	6
207	R:R:I274	R:R:L277	4.28	No	No	0	5	6
208	R:R:L275	R:R:L290	2.77	No	Yes	0	4	3
209	R:R:F296	R:R:L275	9.74	No	No	0	4	4
210	R:R:D279	R:R:L276	4.07	Yes	Yes	1	4	6
211	R:R:D279	R:R:V280	2.92	Yes	Yes	1	4	4
212	R:R:D279	R:R:L290	4.07	Yes	Yes	1	4	3
213	R:R:G281	R:R:V280	3.68	No	Yes	0	4	4
214	R:R:C282	R:R:C287	7.28	No	No	1	4	3
215	R:R:C282	R:R:L290	3.17	No	Yes	1	4	3
216	R:R:K285	R:R:V284	3.04	No	No	0	2	1
217	R:R:C287	R:R:L290	6.35	No	Yes	1	3	3
218	R:R:E294	R:R:Y295	17.96	No	No	0	3	3
219	R:R:S304	R:R:V301	3.23	No	No	0	9	7
220	R:R:N303	R:R:N307	5.45	No	No	0	9	9
221	R:R:I309	R:R:L313	4.28	No	No	0	6	6
222	R:R:M318	R:R:T312	12.04	Yes	No	0	8	7
223	R:R:N315	R:R:T314	2.92	No	No	0	8	7
224	R:R:M318	R:R:N315	7.01	Yes	No	3	8	8
225	R:R:F322	R:R:I323	5.02	No	No	0	7	3
226	R:R:F118	R:R:I179	2.51	Yes	No	0	6	5
227	R:R:M146	R:R:R231	2.48	Yes	Yes	0	8	7
228	R:R:F205	R:R:L174	2.44	No	No	0	5	5
229	R:R:L163	R:R:R159	2.43	No	Yes	2	6	5
230	R:R:I84	R:R:Y81	2.42	No	Yes	0	8	9
231	R:R:F161	R:R:N157	2.42	No	No	0	2	1
232	R:R:I217	R:R:Y221	2.42	No	Yes	0	8	9
233	R:R:D288	R:R:F291	2.39	No	No	0	3	1
234	R:R:L147	R:R:Y143	2.34	No	No	0	6	8
235	R:R:E317	R:R:R320	2.33	No	No	0	7	5
236	R:R:L93	R:R:W168	2.28	No	No	0	6	9
237	R:R:L177	R:R:W182	2.28	No	No	0	5	5
238	R:R:G175	R:R:G176	2.11	No	No	0	6	4
239	R:R:G305	R:R:P308	2.03	No	No	0	7	9
240	R:R:A88	R:R:G85	1.95	No	No	0	9	5
241	R:R:A94	R:R:G95	1.95	No	No	0	8	7
242	R:R:A270	R:R:P271	1.87	No	No	0	6	9
243	R:R:G305	R:R:S304	1.86	No	No	0	7	9
244	R:R:G33	R:R:T32	1.82	No	No	0	7	8
245	R:R:A127	R:R:A94	1.79	No	No	0	6	8
246	R:R:G85	R:R:I70	1.76	No	No	0	5	7
247	R:R:P196	R:R:T32	1.75	No	No	0	3	8
248	R:R:G181	R:R:M180	1.75	No	No	0	5	4
249	R:R:C184	R:R:S190	1.72	No	No	0	5	4
250	R:R:A187	R:R:S190	1.71	No	No	0	4	4
251	R:R:C222	R:R:V218	1.71	No	No	0	3	4
252	R:R:A127	R:R:V126	1.7	No	No	0	6	5
253	R:R:G154	R:R:N153	1.7	No	No	0	4	4
254	R:R:A293	R:R:V194	1.7	No	Yes	0	4	4
255	R:R:C282	R:R:T286	1.69	No	No	0	4	1
256	R:R:A115	R:R:T113	1.68	No	No	0	2	7
257	R:R:C57	R:R:I53	1.64	No	No	0	5	3
258	R:R:N157	R:R:P79	1.63	No	No	0	1	7
259	R:R:S232	R:R:T236	1.6	No	No	0	5	4
260	R:R:T306	R:R:V264	1.59	No	No	0	5	7
261	R:R:A100	R:R:L104	1.58	No	No	0	7	4
262	R:R:A300	R:R:L272	1.58	No	No	0	7	6
263	R:R:T207	R:R:T208	1.57	Yes	No	0	5	4
264	R:R:I185	R:R:S186	1.55	No	No	0	3	1
265	R:R:I259	R:R:S263	1.55	No	No	0	5	5
266	R:R:I55	R:R:V51	1.54	No	No	0	6	5
267	R:R:I55	R:R:V298	1.54	No	No	0	6	5
268	R:R:I170	R:R:V169	1.54	No	No	0	4	4
269	R:R:I266	R:R:V218	1.54	No	No	0	6	4
270	R:R:I260	R:R:V261	1.54	No	No	0	6	8
271	R:R:I309	R:R:T306	1.52	No	No	0	6	5
272	R:R:I310	R:R:T314	1.52	No	No	0	8	7
273	R:R:L102	R:R:S49	1.5	No	No	0	5	5
274	R:R:K72	R:R:T73	1.5	No	No	0	6	6
275	R:R:K283	R:R:T286	1.5	No	No	0	1	1
276	R:R:L262	R:R:V258	1.49	No	No	0	7	8
277	R:R:L68	R:R:T69	1.47	No	No	0	4	8
278	R:R:L103	R:R:T99	1.47	No	No	0	6	6
279	R:R:L212	R:R:T208	1.47	No	No	0	5	4
280	R:R:L215	R:R:T211	1.47	No	No	0	4	4
281	R:R:G122	R:R:Y198	1.45	No	Yes	0	6	4
282	R:R:F118	R:R:P114	1.44	Yes	No	0	6	3
283	R:R:I25	R:R:L197	1.43	No	Yes	0	4	4
284	R:R:I59	R:R:L302	1.43	No	No	0	7	6
285	R:R:I64	R:R:L61	1.43	No	No	0	4	4
286	R:R:I170	R:R:L174	1.43	No	No	0	4	5
287	R:R:I289	R:R:L278	1.43	No	No	0	3	4
288	R:R:P114	R:R:Y22	1.39	No	No	0	3	5
289	R:R:L89	R:R:L92	1.38	No	Yes	0	5	6
290	R:R:L147	R:R:L227	1.38	No	No	0	6	6
291	R:R:L278	R:R:L290	1.38	No	Yes	0	4	3
292	R:R:R120	R:R:S123	1.32	Yes	No	0	6	4
293	R:R:F291	R:R:T193	1.3	No	No	0	1	5
294	R:R:R324	R:R:T73	1.29	No	No	0	4	6
295	R:R:H152	R:R:L151	1.29	No	No	0	7	4
296	R:R:R231	R:R:T230	1.29	Yes	No	0	7	5
297	R:R:K316	R:R:R319	1.24	No	No	0	6	8
298	R:R:L313	R:R:R319	1.21	No	No	0	6	8
299	R:R:D23	R:R:R27	1.19	No	No	0	7	3
300	R:R:D288	R:R:R292	1.19	No	No	0	3	4
301	R:R:L35	R:R:Y29	1.17	No	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.54267	15	1	0
2	R:R:H28	5.53167	6	0	8
3	R:R:Y29	4.06	6	1	7
4	R:R:F52	7.095	4	1	6
5	R:R:F76	10.58	4	0	8
6	R:R:R78	6.315	4	0	7
7	R:R:Y81	9.622	5	3	9
8	R:R:F83	5.376	5	2	8
9	R:R:L87	6.03	4	0	9
10	R:R:D91	6.8425	4	0	9
11	R:R:L92	3.1575	4	0	6
12	R:R:Y98	4.775	6	1	6
13	R:R:W117	6.13375	8	1	9
14	R:R:F118	6.44	5	1	6
15	R:R:R120	7.39	5	1	6
16	R:R:E121	8.3475	4	1	5
17	R:R:M124	4.2925	4	1	6
18	R:R:I138	4.4075	4	2	8
19	R:R:R142	4.2375	4	2	9
20	R:R:M146	3.59	4	0	8
21	R:R:R159	4.365	4	2	5
22	R:R:V194	3.85	4	1	4
23	R:R:L195	5.158	5	1	3
24	R:R:L197	6.1075	4	1	4
25	R:R:Y198	5.01333	6	1	4
26	R:R:Y202	7.665	4	1	7
27	R:R:I203	3.3125	4	1	6
28	R:R:T207	3.9	4	0	5
29	R:R:Y221	3.846	5	0	9
30	R:R:Y225	5.1075	4	4	6
31	R:R:R231	4.645	4	0	7
32	R:R:W269	6.206	5	1	8
33	R:R:F273	5.115	4	0	6
34	R:R:L276	4.942	5	1	6
35	R:R:D279	3.77667	6	1	4
36	R:R:V280	4.315	4	1	4
37	R:R:L290	3.94	6	1	3
38	R:R:Y311	4.6075	4	2	9
39	R:R:M318	6.99	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y29	30.2848	6.21	Yes	Yes	1	0	7
2	L:L:?1	R:R:M124	17.944	3.74	Yes	Yes	1	0	6
3	L:L:?1	R:R:L195	19.1126	8.25	Yes	Yes	1	0	3
4	R:R:W117	R:R:Y29	14.2354	2.89	Yes	Yes	1	9	7
5	R:R:L195	R:R:W117	15.7829	4.56	Yes	Yes	1	3	9
6	L:L:?1	R:R:W269	94.8539	4.53	Yes	Yes	1	0	8
7	L:L:?1	R:R:L297	15.1057	8.25	Yes	No	1	0	5
8	R:R:P196	R:R:Y29	13.1182	5.56	No	Yes	0	3	7
9	R:R:H28	R:R:P196	10.8886	6.1	Yes	No	0	8	3
10	R:R:M124	R:R:Y98	15.25	3.59	Yes	Yes	1	6	6
11	R:R:L297	R:R:Y98	14.2941	3.52	No	Yes	1	5	6
12	R:R:C56	R:R:Y98	12.3359	5.38	No	Yes	0	5	6
13	R:R:C56	R:R:T99	10.5879	3.38	No	No	0	5	6
14	R:R:N303	R:R:W269	100	7.91	No	Yes	0	9	8
15	R:R:N303	R:R:N307	99.8924	5.45	No	No	0	9	9
16	R:R:L135	R:R:N307	75.2744	4.12	No	No	0	9	9
17	R:R:L135	R:R:Y311	63.6621	3.52	No	Yes	0	9	9
18	R:R:R142	R:R:Y311	38.7923	5.14	Yes	Yes	2	9	9
19	R:R:M80	R:R:R142	29.9328	4.96	No	Yes	0	8	9
20	R:R:M80	R:R:R78	31.3556	7.44	No	Yes	0	8	7
21	R:R:R78	R:R:Y81	27.2363	11.32	Yes	Yes	0	7	9
22	R:R:D91	R:R:N307	25.0043	2.69	Yes	No	0	9	9
23	R:R:D91	R:R:S304	10.5806	11.78	Yes	No	0	9	9
24	R:R:F76	R:R:Y81	11.5878	23.73	Yes	Yes	0	8	9
25	R:R:D91	R:R:L87	16.8879	4.07	Yes	Yes	0	9	9
26	R:R:I138	R:R:L87	22.8994	2.85	Yes	Yes	0	8	9
27	R:R:F83	R:R:I138	23.9824	3.77	Yes	Yes	2	8	8
28	R:R:L135	R:R:L87	11.9594	9.69	No	Yes	0	9	9
29	R:R:F83	R:R:L163	12.9202	4.87	Yes	No	2	8	6
30	R:R:F118	R:R:W117	27.1385	4.01	Yes	Yes	1	6	9
31	R:R:R142	R:R:Y221	22.2956	3.09	Yes	Yes	0	9	9
32	R:R:I217	R:R:Y221	32.6366	2.42	No	Yes	0	8	9
33	R:R:I217	R:R:L136	31.3825	4.28	No	No	0	8	7
34	R:R:I140	R:R:L136	28.8596	5.71	No	No	0	6	7
35	R:R:V261	R:R:Y311	17.1984	2.52	No	Yes	0	8	9
36	R:R:V261	R:R:Y221	15.7365	2.52	No	Yes	0	8	9
37	R:R:I140	R:R:L220	27.5908	2.85	No	No	0	6	7
38	R:R:L220	R:R:Y143	26.3171	3.52	No	No	0	7	8
39	R:R:L163	R:R:R159	11.0867	2.43	No	Yes	2	6	5
40	R:R:L147	R:R:Y143	22.4667	2.34	No	No	0	6	8
41	R:R:L147	R:R:L227	21.1686	1.38	No	No	0	6	6
42	R:R:L227	R:R:R231	19.9609	3.64	No	Yes	0	6	7
43	R:R:M146	R:R:R231	16.0323	2.48	Yes	Yes	0	8	7
44	R:R:M146	R:R:V228	12.0645	3.04	Yes	No	0	8	8
45	R:R:F118	R:R:I179	10.7786	2.51	Yes	No	0	6	5
46	L:L:?1	R:R:L276	22.0364	9.17	Yes	Yes	1	0	6
47	R:R:D279	R:R:L276	14.849	4.07	Yes	Yes	1	4	6
48	R:R:D279	R:R:L290	13.414	4.07	Yes	Yes	1	4	3
49	R:R:L254	R:R:V228	10.7346	4.47	No	No	0	8	8
50	L:L:?1	R:R:E121	17.2717	8.77	Yes	Yes	1	0	5
51	R:R:E121	R:R:W117	13.546	16.36	Yes	Yes	1	5	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y29	6.21	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:K34	8.4	1	Yes	No	0	6	0	1
L:L:?1	R:R:E121	8.77	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M124	3.74	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F125	16.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:L128	5.5	1	Yes	No	0	6	0	1
L:L:?1	R:R:S129	7.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:V132	3.95	1	Yes	No	0	7	0	1
L:L:?1	R:R:L195	8.25	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:V209	2.96	1	Yes	No	0	5	0	1
L:L:?1	R:R:F210	12.1	1	Yes	No	0	7	0	1
L:L:?1	R:R:W269	4.53	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L272	6.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:L276	9.17	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L297	8.25	1	Yes	No	0	5	0	1
R:R:K34	R:R:Y29	4.78	1	No	Yes	6	7	1	1
R:R:T109	R:R:Y29	3.75	0	No	Yes	5	7	2	1
R:R:W117	R:R:Y29	2.89	1	Yes	Yes	9	7	2	1
R:R:P196	R:R:Y29	5.56	0	No	Yes	3	7	2	1
R:R:M124	R:R:Y98	3.59	1	Yes	Yes	6	6	1	2
R:R:L297	R:R:Y98	3.52	1	No	Yes	5	6	1	2
R:R:M124	R:R:N101	7.01	1	Yes	No	6	5	1	2
R:R:E121	R:R:W117	16.36	1	Yes	Yes	5	9	1	2
R:R:L195	R:R:W117	4.56	1	Yes	Yes	3	9	1	2
R:R:W117	R:R:Y198	3.86	1	Yes	Yes	9	4	2	2
R:R:E121	R:R:L195	2.65	1	Yes	Yes	5	3	1	1
R:R:E121	R:R:Y198	5.61	1	Yes	Yes	5	4	1	2
R:R:L297	R:R:M124	2.83	1	No	Yes	5	6	1	1
R:R:F125	R:R:Y202	5.16	0	No	Yes	5	7	1	2
R:R:L128	R:R:W269	4.56	1	No	Yes	6	8	1	1
R:R:L213	R:R:V132	2.98	0	No	No	8	7	2	1
R:R:L195	R:R:V194	4.47	1	Yes	Yes	3	4	1	2
R:R:D279	R:R:V194	4.38	1	Yes	Yes	4	4	2	2
R:R:L195	R:R:Y198	5.86	1	Yes	Yes	3	4	1	2
R:R:Y198	R:R:Y202	4.96	1	Yes	Yes	4	7	2	2
R:R:I203	R:R:L276	4.28	1	Yes	Yes	6	6	2	1
R:R:D279	R:R:I203	2.8	1	Yes	Yes	4	6	2	2
R:R:F273	R:R:T207	5.19	0	Yes	Yes	6	5	2	2
R:R:L276	R:R:T207	4.42	1	Yes	Yes	6	5	1	2
R:R:F210	R:R:W269	9.02	1	No	Yes	7	8	1	1
R:R:F210	R:R:F273	6.43	1	No	Yes	7	6	1	2
R:R:F265	R:R:W269	5.01	0	No	Yes	9	8	2	1
R:R:N303	R:R:W269	7.91	0	No	Yes	9	8	2	1
R:R:L272	R:R:L276	2.77	1	No	Yes	6	6	1	1
R:R:D279	R:R:L276	4.07	1	Yes	Yes	4	6	2	1
R:R:A300	R:R:L272	1.58	0	No	No	7	6	2	1
R:R:L35	R:R:Y29	1.17	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EVY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.52
Number of Linked Nodes	269
Number of Links	301
Number of Hubs	39
Number of Links mediated by Hubs	149
Number of Communities	4
Number of Nodes involved in Communities	47
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	52
Number Of Links MetaPath	51
Number of Shortest Paths	64583
Length Of Smallest Path	3
Average Path Length	13.5942
Length of Longest Path	31
Minimum Path Strength	1.225
Average Path Strength	5.2413
Maximum Path Strength	17.525
Minimum Path Correlation	0.7
Average Path Correlation	0.937903
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	56.8154
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.0964
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	J8C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J8C
Name	Siponimod
Synonyms	Siponimod fumarate Siponimod
Identifier
Formula	C29 H35 F3 N2 O3
Molecular Weight	516.595
SMILES
PubChem	72959169
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	75
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7EVY_nogp_Chain_R Y D I I V R H Y N Y T G K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R K N I S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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You can also read or download a guide explaining the meaning of all files and numerical data.