psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D23	R:R:N21	5.39	No	No	0	7	8
2	R:R:H28	R:R:I24	3.98	Yes	Yes	0	8	4
3	R:R:I185	R:R:I24	2.94	No	Yes	0	3	4
4	R:R:I25	R:R:Y29	3.63	Yes	Yes	1	4	7
5	R:R:I25	R:R:W117	4.7	Yes	Yes	1	4	9
6	R:R:I25	R:R:L197	5.71	Yes	Yes	1	4	4
7	R:R:C184	R:R:H28	2.95	No	Yes	0	5	8
8	R:R:H28	R:R:L188	6.43	Yes	No	0	8	2
9	R:R:H28	R:R:L197	7.71	Yes	Yes	0	8	4
10	R:R:K34	R:R:Y29	3.58	No	Yes	1	6	7
11	R:R:Y110	R:R:Y29	6.95	No	Yes	0	5	7
12	R:R:P196	R:R:Y29	11.13	No	Yes	1	3	7
13	R:R:L35	R:R:N30	9.61	No	No	0	6	9
14	R:R:L188	R:R:Y31	10.55	No	No	0	2	5
15	R:R:C191	R:R:Y31	5.38	No	No	0	9	5
16	R:R:K34	R:R:T32	3	No	Yes	1	6	8
17	R:R:T193	R:R:T32	4.71	No	Yes	0	5	8
18	R:R:P196	R:R:T32	5.25	No	Yes	1	3	8
19	R:R:K34	R:R:P196	3.35	No	No	1	6	3
20	R:R:A107	R:R:N36	4.69	No	No	0	4	4
21	R:R:N36	R:R:Y110	5.81	No	No	0	4	5
22	R:R:K46	R:R:T48	4.5	No	No	0	4	5
23	R:R:F52	R:R:T48	7.78	Yes	No	2	6	5
24	R:R:T48	R:R:Y295	6.24	No	Yes	2	5	3
25	R:R:F52	R:R:L102	3.65	Yes	No	0	6	5
26	R:R:E294	R:R:F52	4.66	No	Yes	2	3	6
27	R:R:F52	R:R:Y295	6.19	Yes	Yes	2	6	3
28	R:R:F52	R:R:V298	22.28	Yes	No	0	6	5
29	R:R:I53	R:R:T99	3.04	No	Yes	0	3	6
30	R:R:I55	R:R:V298	3.07	No	No	0	6	5
31	R:R:C56	R:R:I60	3.27	Yes	No	0	5	6
32	R:R:C56	R:R:Y98	4.03	Yes	Yes	0	5	6
33	R:R:E62	R:R:F58	16.32	Yes	No	0	8	4
34	R:R:E62	R:R:I59	4.1	Yes	Yes	0	8	7
35	R:R:I59	R:R:N63	4.25	Yes	Yes	3	7	9
36	R:R:D91	R:R:I59	4.2	Yes	Yes	3	9	7
37	R:R:I59	R:R:V301	3.07	Yes	No	0	7	7
38	R:R:G305	R:R:I59	7.05	No	Yes	3	7	7
39	R:R:I60	R:R:I64	2.94	No	No	0	6	4
40	R:R:I60	R:R:L92	2.85	No	No	0	6	6
41	R:R:F65	R:R:L61	3.65	No	No	0	7	4
42	R:R:D91	R:R:N63	17.5	Yes	Yes	3	9	9
43	R:R:L92	R:R:N63	5.49	No	Yes	0	6	9
44	R:R:N63	R:R:P308	4.89	Yes	No	3	9	9
45	R:R:P308	R:R:V66	7.07	No	No	0	9	9
46	R:R:L68	R:R:T69	2.95	No	No	0	4	8
47	R:R:I70	R:R:K75	2.91	No	Yes	0	7	6
48	R:R:F76	R:R:W71	9.02	No	No	0	8	3
49	R:R:I323	R:R:K72	2.91	No	No	0	3	6
50	R:R:K75	R:R:T73	10.51	Yes	No	0	6	6
51	R:R:A321	R:R:T73	5.03	No	No	0	7	6
52	R:R:F76	R:R:K74	8.69	No	No	0	8	6
53	R:R:K75	R:R:R78	8.66	Yes	No	4	6	7
54	R:R:K75	R:R:Y81	10.75	Yes	Yes	4	6	9
55	R:R:E317	R:R:K75	4.05	No	Yes	0	7	6
56	R:R:K75	R:R:M318	2.88	Yes	Yes	4	6	8
57	R:R:R78	R:R:Y81	6.17	No	Yes	4	7	9
58	R:R:P79	R:R:S155	5.34	No	No	6	7	7
59	R:R:N157	R:R:P79	3.26	No	No	6	1	7
60	R:R:N315	R:R:Y81	8.14	No	Yes	4	8	9
61	R:R:M318	R:R:Y81	11.97	Yes	Yes	4	8	9
62	R:R:L160	R:R:Y82	7.03	No	No	0	7	4
63	R:R:F83	R:R:I138	3.77	No	Yes	0	8	8
64	R:R:E141	R:R:F83	9.33	Yes	No	0	9	8
65	R:R:F83	R:R:I164	5.02	No	Yes	0	8	7
66	R:R:I84	R:R:Y311	4.84	No	Yes	0	8	9
67	R:R:N86	R:R:S134	7.45	Yes	No	0	9	8
68	R:R:I164	R:R:N86	5.66	Yes	Yes	0	7	9
69	R:R:C167	R:R:N86	3.15	No	Yes	0	6	9
70	R:R:N86	R:R:W168	10.17	Yes	Yes	0	9	9
71	R:R:L87	R:R:S134	6.01	Yes	No	0	9	8
72	R:R:I138	R:R:L87	2.85	Yes	Yes	5	8	9
73	R:R:L87	R:R:N307	4.12	Yes	No	0	9	9
74	R:R:L87	R:R:Y311	3.52	Yes	Yes	5	9	9
75	R:R:A130	R:R:S90	3.42	No	No	0	7	8
76	R:R:D91	R:R:S304	10.31	Yes	No	0	9	9
77	R:R:D91	R:R:G305	5.03	Yes	No	3	9	7
78	R:R:D91	R:R:P308	4.83	Yes	No	3	9	9
79	R:R:L102	R:R:Y98	9.38	No	Yes	0	5	6
80	R:R:M124	R:R:Y98	7.18	No	Yes	0	6	6
81	R:R:L297	R:R:Y98	8.21	No	Yes	0	5	6
82	R:R:V298	R:R:Y98	7.57	No	Yes	0	5	6
83	R:R:V301	R:R:Y98	5.05	No	Yes	0	7	6
84	R:R:N101	R:R:S105	5.96	No	No	1	5	4
85	R:R:N101	R:R:R120	13.26	No	Yes	1	5	6
86	R:R:E121	R:R:N101	6.57	Yes	No	1	5	5
87	R:R:R120	R:R:S105	3.95	Yes	No	1	6	4
88	R:R:K111	R:R:T108	9.01	No	No	0	1	4
89	R:R:R120	R:R:T109	6.47	Yes	No	0	6	5
90	R:R:K111	R:R:L112	4.23	No	No	0	1	5
91	R:R:L112	R:R:Q116	11.98	No	No	0	5	4
92	R:R:P114	R:R:T113	6.99	No	Yes	0	3	7
93	R:R:A115	R:R:T113	3.36	No	Yes	0	2	7
94	R:R:Q116	R:R:T113	7.09	No	Yes	0	4	7
95	R:R:F118	R:R:W117	5.01	Yes	Yes	1	6	9
96	R:R:R120	R:R:W117	7	Yes	Yes	1	6	9
97	R:R:E121	R:R:W117	9.81	Yes	Yes	1	5	9
98	R:R:L195	R:R:W117	3.42	Yes	Yes	1	3	9
99	R:R:L197	R:R:W117	14.81	Yes	Yes	1	4	9
100	R:R:W117	R:R:Y198	4.82	Yes	Yes	1	9	4
101	R:R:F118	R:R:P178	2.89	Yes	Yes	1	6	5
102	R:R:F118	R:R:I179	6.28	Yes	No	0	6	5
103	R:R:F118	R:R:N183	9.67	Yes	No	0	6	5
104	R:R:F118	R:R:L197	7.31	Yes	Yes	1	6	4
105	R:R:E121	R:R:R120	11.63	Yes	Yes	1	5	6
106	R:R:E121	R:R:Y198	4.49	Yes	Yes	1	5	4
107	R:R:L128	R:R:M124	4.24	No	No	0	6	6
108	R:R:F125	R:R:L195	3.65	No	Yes	1	5	3
109	R:R:F125	R:R:Y198	6.19	No	Yes	1	5	4
110	R:R:F125	R:R:Y202	5.16	No	Yes	1	5	7
111	R:R:S171	R:R:V126	3.23	No	No	0	8	5
112	R:R:L172	R:R:V126	4.47	No	No	0	4	5
113	R:R:L128	R:R:W269	7.97	No	Yes	0	6	8
114	R:R:S129	R:R:S171	3.26	No	No	0	6	8
115	R:R:L174	R:R:S129	3	No	No	0	5	6
116	R:R:A130	R:R:W168	5.19	No	Yes	0	7	9
117	R:R:A130	R:R:S171	3.42	No	No	0	7	8
118	R:R:S131	R:R:S304	6.52	No	No	0	9	9
119	R:R:L213	R:R:V132	4.47	No	No	0	8	7
120	R:R:V132	R:R:W269	4.9	No	Yes	0	7	8
121	R:R:F133	R:R:I170	7.54	No	No	0	5	4
122	R:R:F133	R:R:L213	14.61	No	No	0	5	8
123	R:R:I217	R:R:L135	4.28	No	No	0	8	9
124	R:R:F265	R:R:L135	4.87	No	No	0	9	9
125	R:R:L135	R:R:Y311	4.69	No	Yes	0	9	9
126	R:R:I140	R:R:L136	7.14	No	No	0	6	7
127	R:R:L136	R:R:S216	3	No	No	0	7	6
128	R:R:I217	R:R:L136	4.28	No	No	0	8	7
129	R:R:A137	R:R:L163	4.73	No	No	0	7	6
130	R:R:I138	R:R:R142	7.52	Yes	No	5	8	9
131	R:R:I138	R:R:Y311	3.63	Yes	Yes	5	8	9
132	R:R:A139	R:R:L220	3.15	No	No	0	8	7
133	R:R:A139	R:R:Y221	4	No	Yes	0	8	9
134	R:R:I140	R:R:I144	2.94	No	No	0	6	4
135	R:R:I140	R:R:L163	5.71	No	No	0	6	6
136	R:R:E141	R:R:T145	4.23	Yes	No	0	9	8
137	R:R:E141	R:R:R159	9.3	Yes	No	0	9	5
138	R:R:R142	R:R:Y221	8.23	No	Yes	5	9	9
139	R:R:R142	R:R:Y311	8.23	No	Yes	5	9	9
140	R:R:L147	R:R:Y143	3.52	No	Yes	0	6	8
141	R:R:L220	R:R:Y143	7.03	No	Yes	0	7	8
142	R:R:R223	R:R:Y143	16.46	No	Yes	0	5	8
143	R:R:I224	R:R:Y143	4.84	No	Yes	0	9	8
144	R:R:I144	R:R:K148	2.91	No	No	0	4	6
145	R:R:I144	R:R:R159	15.03	No	No	0	4	5
146	R:R:I224	R:R:M146	4.37	No	No	0	9	8
147	R:R:M149	R:R:R231	12.41	No	No	0	8	7
148	R:R:G154	R:R:K150	5.23	No	No	0	4	7
149	R:R:H152	R:R:L151	3.86	No	No	0	7	4
150	R:R:G154	R:R:N153	3.39	No	No	0	4	4
151	R:R:N157	R:R:S155	5.96	No	No	6	1	7
152	R:R:N156	R:R:R159	12.05	No	No	0	7	5
153	R:R:N157	W:W:V41	4.43	No	No	0	1	0
154	R:R:I164	R:R:L160	5.71	Yes	No	0	7	7
155	R:R:F161	R:R:S165	9.25	Yes	No	7	2	4
156	R:R:F161	W:W:V45	5.24	Yes	Yes	7	2	0
157	R:R:I164	W:W:V45	3.07	Yes	Yes	0	7	0
158	R:R:S165	W:W:V45	3.23	No	Yes	7	4	0
159	R:R:V169	W:W:T52	7.93	No	No	0	4	0
160	R:R:L177	R:R:Y202	7.03	No	Yes	0	5	7
161	R:R:P178	R:R:Y198	12.52	Yes	Yes	1	5	4
162	R:R:P178	R:R:Y202	12.52	Yes	Yes	1	5	7
163	R:R:I179	W:W:A60	3.25	No	No	0	5	0
164	R:R:M180	W:W:I56	5.83	No	No	0	4	0
165	R:R:M180	W:W:I59	10.2	No	No	0	4	0
166	R:R:G181	R:R:N183	5.09	No	No	0	5	5
167	R:R:H199	R:R:W182	11.64	No	No	0	4	5
168	R:R:W182	R:R:Y202	4.82	No	Yes	0	5	7
169	R:R:I185	R:R:N183	11.33	No	No	0	3	5
170	R:R:C184	R:R:S190	3.44	No	No	0	5	4
171	R:R:H199	R:R:S190	5.58	No	No	0	4	4
172	R:R:S192	R:R:V194	3.23	No	Yes	0	4	4
173	R:R:I203	R:R:S192	3.1	No	No	0	6	4
174	R:R:K285	R:R:T193	3	No	No	0	2	5
175	R:R:F291	R:R:T193	5.19	No	No	0	1	5
176	R:R:L195	R:R:V194	2.98	Yes	Yes	1	3	4
177	R:R:D279	R:R:V194	5.84	No	Yes	1	4	4
178	R:R:L290	R:R:V194	4.47	Yes	Yes	1	3	4
179	R:R:L195	R:R:Y198	10.55	Yes	Yes	1	3	4
180	R:R:Y198	R:R:Y202	6.95	Yes	Yes	1	4	7
181	R:R:I203	R:R:Y198	4.84	No	Yes	0	6	4
182	R:R:H199	R:R:H201	14.33	No	No	0	4	4
183	R:R:K200	R:R:V280	3.04	No	No	0	3	4
184	R:R:H201	R:R:L204	5.14	No	No	0	4	5
185	R:R:I203	R:R:L276	2.85	No	No	0	6	6
186	R:R:L204	R:R:V280	2.98	No	No	0	5	4
187	R:R:F205	R:R:V209	3.93	No	No	0	5	5
188	R:R:L276	R:R:T207	4.42	No	No	0	6	5
189	R:R:L277	R:R:T207	2.95	No	No	0	6	5
190	R:R:F210	R:R:W269	16.04	No	Yes	0	7	8
191	R:R:F210	R:R:F273	3.22	No	Yes	0	7	6
192	R:R:F273	R:R:T211	7.78	Yes	No	0	6	4
193	R:R:F265	R:R:L214	7.31	No	No	0	9	5
194	R:R:I266	R:R:L214	4.28	No	No	0	6	5
195	R:R:I219	R:R:L215	2.85	No	No	0	4	4
196	R:R:L262	R:R:V218	5.96	No	No	0	7	4
197	R:R:V258	R:R:Y221	3.79	No	Yes	0	8	9
198	R:R:Y221	R:R:Y311	3.97	Yes	Yes	5	9	9
199	R:R:L254	R:R:Y225	3.52	No	Yes	0	8	6
200	R:R:L255	R:R:Y225	18.76	No	Yes	0	8	6
201	R:R:L254	R:R:V228	4.47	No	No	0	8	8
202	R:R:R229	R:R:R233	10.66	No	No	0	5	4
203	R:R:F237	R:R:L235	3.65	No	No	0	3	6
204	R:R:K239	R:R:R238	3.71	No	No	0	2	5
205	R:R:L254	R:R:V258	2.98	No	No	0	8	8
206	R:R:T257	R:R:T314	4.71	No	No	0	9	7
207	R:R:L262	R:R:V258	2.98	No	No	0	7	8
208	R:R:V261	R:R:Y311	3.79	No	Yes	0	8	9
209	R:R:S263	R:R:V264	3.23	No	No	0	5	7
210	R:R:I310	R:R:V264	4.61	No	No	0	8	7
211	R:R:F265	R:R:W269	7.02	No	Yes	0	9	8
212	R:R:C268	R:R:N303	4.72	No	No	0	8	9
213	R:R:N303	R:R:W269	12.43	No	Yes	0	9	8
214	R:R:F296	R:R:P271	2.89	No	No	0	4	9
215	R:R:L299	R:R:P271	3.28	No	No	0	7	9
216	R:R:F296	R:R:L272	6.09	No	No	0	4	6
217	R:R:A300	R:R:L272	3.15	No	No	0	7	6
218	R:R:F273	R:R:L277	7.31	Yes	No	0	6	6
219	R:R:F296	R:R:L275	19.49	No	No	0	4	4
220	R:R:D279	R:R:V280	2.92	No	No	0	4	4
221	R:R:D279	R:R:L290	4.07	No	Yes	1	4	3
222	R:R:C282	R:R:K283	3.23	No	No	0	4	1
223	R:R:C282	R:R:C287	3.64	No	No	0	4	3
224	R:R:K285	R:R:V284	4.55	No	No	0	2	1
225	R:R:C287	R:R:L290	3.17	No	Yes	0	3	3
226	R:R:E294	R:R:R292	5.82	No	No	2	3	4
227	R:R:R292	R:R:Y295	9.26	No	Yes	2	4	3
228	R:R:E294	R:R:Y295	11.22	No	Yes	2	3	3
229	R:R:N303	R:R:N307	9.54	No	No	0	9	9
230	R:R:I309	R:R:T306	3.04	No	No	0	6	5
231	R:R:I310	R:R:Y311	3.63	No	Yes	0	8	9
232	R:R:M318	R:R:T312	7.53	Yes	No	0	8	7
233	R:R:L313	R:R:R319	6.07	No	No	0	6	8
234	R:R:M318	R:R:N315	11.22	Yes	No	4	8	8
235	R:R:K316	R:R:R319	17.33	No	No	0	6	8
236	R:R:E317	R:R:R320	3.49	No	No	0	7	5
237	W:W:C43	W:W:P40	3.77	No	No	0	0	0
238	W:W:F50	W:W:M46	3.73	No	No	0	0	0
239	W:W:I51	W:W:I55	2.94	No	No	0	0	0
240	W:W:I51	Z:Z:H47	7.95	No	No	0	0	0
241	W:W:L54	Z:Z:I54	4.28	No	No	0	0	0
242	W:W:L54	Z:Z:K58	5.64	No	No	0	0	0
243	W:W:I55	Z:Z:I54	4.42	No	No	0	0	0
244	W:W:A57	Z:Z:K58	4.82	No	No	0	0	0
245	W:W:I59	W:W:L58	2.85	No	No	0	0	0
246	W:W:L61	Z:Z:F62	7.31	No	No	0	0	0
247	Z:Z:N42	Z:Z:Q41	6.6	No	No	0	0	0
248	Z:Z:T50	Z:Z:V53	4.76	No	No	0	0	0
249	Z:Z:E57	Z:Z:V53	9.98	No	No	0	0	0
250	Z:Z:D55	Z:Z:S56	4.42	No	No	0	0	0
251	Z:Z:D55	Z:Z:D59	3.99	No	No	0	0	0
252	Z:Z:E57	Z:Z:M60	8.12	No	No	0	0	0
253	R:R:L177	R:R:M180	2.83	No	No	0	5	4
254	W:W:L42	W:W:M46	2.83	No	No	0	0	0
255	R:R:L147	R:R:L227	2.77	No	No	0	6	6
256	R:R:F161	W:W:A44	2.77	Yes	No	0	2	0
257	R:R:L275	R:R:L290	2.77	No	Yes	0	4	3
258	R:R:E62	R:R:I309	2.73	Yes	No	0	8	6
259	R:R:E141	R:R:M80	2.71	Yes	No	0	9	8
260	R:R:F52	R:R:V51	2.62	Yes	No	0	6	5
261	R:R:F133	R:R:V209	2.62	No	No	0	5	5
262	R:R:F161	W:W:V48	2.62	Yes	No	0	2	0
263	R:R:S251	R:R:Y225	2.54	No	Yes	0	7	6
264	R:R:F322	R:R:I325	2.51	No	No	0	7	6
265	R:R:T113	R:R:Y22	2.5	Yes	No	0	7	5
266	R:R:L104	R:R:R120	2.43	No	Yes	0	4	6
267	R:R:L227	R:R:R231	2.43	No	No	0	6	7
268	R:R:D23	R:R:R27	2.38	No	No	0	7	3
269	R:R:L89	R:R:W168	2.28	No	Yes	0	5	9
270	R:R:L93	R:R:W168	2.28	No	Yes	0	6	9
271	R:R:G122	R:R:G175	2.11	No	No	0	6	6
272	R:R:G175	R:R:G176	2.11	No	No	0	6	4
273	R:R:R229	R:R:Y225	2.06	No	Yes	0	5	6
274	R:R:G176	R:R:P178	2.03	No	Yes	0	4	5
275	R:R:C56	R:R:G95	1.96	Yes	No	0	5	7
276	R:R:A88	R:R:G85	1.95	No	No	0	9	5
277	R:R:A94	R:R:G95	1.95	No	No	0	8	7
278	R:R:A270	R:R:P271	1.87	No	No	0	6	9
279	R:R:G106	R:R:S105	1.86	No	No	0	4	4
280	R:R:G181	W:W:V63	1.84	No	No	0	5	0
281	W:W:G64	W:W:V63	1.84	No	No	0	0	0
282	R:R:G33	R:R:T32	1.82	No	Yes	0	7	8
283	R:R:A127	R:R:A94	1.79	No	No	0	6	8
284	R:R:A127	R:R:A97	1.79	No	No	0	6	4
285	R:R:G33	R:R:L35	1.71	No	No	0	7	6
286	R:R:G85	R:R:L67	1.71	No	No	0	5	8
287	R:R:A97	R:R:S123	1.71	No	No	0	4	4
288	R:R:A187	R:R:S189	1.71	No	No	0	4	4
289	R:R:A187	R:R:S190	1.71	No	No	0	4	4
290	R:R:C222	R:R:V218	1.71	No	No	0	3	4
291	Z:Z:G48	Z:Z:L51	1.71	No	No	0	0	0
292	R:R:A88	R:R:V66	1.7	No	No	0	9	9
293	R:R:I24	R:R:P114	1.69	Yes	No	0	4	3
294	R:R:C56	R:R:T99	1.69	Yes	Yes	0	5	6
295	R:R:C282	R:R:T286	1.69	No	No	0	4	1
296	R:R:A321	R:R:T69	1.68	No	No	0	7	8
297	R:R:A100	R:R:T99	1.68	No	Yes	0	7	6
298	R:R:A166	R:R:I170	1.62	No	No	0	3	4
299	R:R:A253	R:R:K250	1.61	No	No	0	7	6
300	R:R:V169	W:W:V48	1.6	No	No	0	4	0
301	R:R:S226	R:R:T230	1.6	No	No	0	3	5
302	W:W:V41	W:W:V45	1.6	No	Yes	0	0	0
303	R:R:T312	R:R:V66	1.59	No	No	0	7	9
304	R:R:T99	R:R:V96	1.59	Yes	No	0	6	5
305	R:R:T257	R:R:V261	1.59	No	No	0	9	8
306	R:R:C287	R:R:L278	1.59	No	No	0	3	4
307	W:W:C43	W:W:L42	1.59	No	No	0	0	0
308	Z:Z:G48	Z:Z:H47	1.59	No	No	0	0	0
309	R:R:I185	R:R:S186	1.55	No	No	0	3	1
310	R:R:I260	R:R:S263	1.55	No	No	0	6	5
311	R:R:I25	R:R:V26	1.54	Yes	No	0	4	6
312	R:R:I53	R:R:V50	1.54	No	No	0	3	5
313	R:R:I173	R:R:V169	1.54	No	No	0	4	4
314	W:W:M46	W:W:V49	1.52	No	No	0	0	0
315	W:W:I51	W:W:T52	1.52	No	No	0	0	0
316	R:R:L102	R:R:S49	1.5	No	No	0	5	5
317	R:R:K72	R:R:T73	1.5	No	No	0	6	6
318	R:R:K150	R:R:T145	1.5	No	No	0	7	8
319	R:R:L47	R:R:V50	1.49	No	No	0	4	5
320	R:R:L54	R:R:V50	1.49	No	No	0	4	5
321	R:R:L54	R:R:V51	1.49	No	No	0	4	5
322	R:R:L172	W:W:V49	1.49	No	No	0	4	0
323	R:R:I259	R:R:I260	1.47	No	No	0	5	6
324	R:R:L313	R:R:T312	1.47	No	No	0	6	7
325	Z:Z:E57	Z:Z:S56	1.44	No	No	0	0	0
326	R:R:I55	R:R:L302	1.43	No	No	0	6	6
327	R:R:I59	R:R:L302	1.43	Yes	No	0	7	6
328	R:R:L172	W:W:I53	1.43	No	No	0	4	0
329	R:R:I37	R:R:N36	1.42	No	No	0	1	4
330	R:R:D23	R:R:I24	1.4	No	Yes	0	7	4
331	R:R:L103	R:R:L104	1.38	No	No	0	6	4
332	R:R:L162	R:R:L163	1.38	No	No	0	3	6
333	R:R:L212	R:R:L213	1.38	No	No	0	5	8
334	W:W:L61	Z:Z:N61	1.37	No	No	0	0	0
335	W:W:L54	Z:Z:D55	1.36	No	No	0	0	0
336	R:R:E62	R:R:L61	1.33	Yes	No	0	8	4
337	Z:Z:E46	Z:Z:N42	1.31	No	No	0	0	0
338	R:R:F322	R:R:T69	1.3	No	No	0	7	8
339	R:R:R231	R:R:T230	1.29	No	No	0	7	5
340	R:R:F273	R:R:I274	1.26	Yes	No	0	6	5
341	R:R:F158	R:R:N156	1.21	No	No	0	4	7
342	R:R:L252	R:R:Y225	1.17	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I24	2.5025	4	0	4
2	R:R:I25	3.895	4	1	4
3	R:R:H28	5.2675	4	0	8
4	R:R:Y29	6.3225	4	1	7
5	R:R:T32	3.695	4	1	8
6	R:R:F52	7.86333	6	2	6
7	R:R:C56	2.7375	4	0	5
8	R:R:I59	4.01667	6	3	7
9	R:R:E62	6.12	4	0	8
10	R:R:N63	8.0325	4	3	9
11	R:R:K75	6.62667	6	4	6
12	R:R:Y81	9.2575	4	4	9
13	R:R:N86	6.6075	4	0	9
14	R:R:L87	4.125	4	5	9
15	R:R:D91	8.374	5	3	9
16	R:R:Y98	6.90333	6	0	6
17	R:R:T99	2	4	0	6
18	R:R:T113	4.985	4	0	7
19	R:R:W117	7.08143	7	1	9
20	R:R:F118	6.232	5	1	6
21	R:R:R120	7.45667	6	1	6
22	R:R:E121	8.125	4	1	5
23	R:R:I138	4.4425	4	5	8
24	R:R:E141	6.3925	4	0	9
25	R:R:Y143	7.9625	4	0	8
26	R:R:F161	4.97	4	7	2
27	R:R:I164	4.865	4	0	7
28	R:R:W168	4.98	4	0	9
29	R:R:P178	7.49	4	1	5
30	R:R:V194	4.13	4	1	4
31	R:R:L195	5.15	4	1	3
32	R:R:L197	8.885	4	1	4
33	R:R:Y198	7.19429	7	1	4
34	R:R:Y202	7.296	5	1	7
35	R:R:Y221	4.9975	4	5	9
36	R:R:Y225	5.61	5	0	6
37	R:R:W269	9.672	5	0	8
38	R:R:F273	4.8925	4	0	6
39	R:R:L290	3.62	4	1	3
40	R:R:Y295	8.2275	4	2	3
41	R:R:Y311	4.5375	8	5	9
42	R:R:M318	8.4	4	4	8
43	W:W:V45	3.285	4	7	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H28	R:R:I24	13.1091	3.98	Yes	Yes	0	8	4
2	R:R:H28	R:R:L197	18.1997	7.71	Yes	Yes	0	8	4
3	R:R:I25	R:R:Y29	25.078	3.63	Yes	Yes	1	4	7
4	R:R:L197	R:R:W117	16.8261	14.81	Yes	Yes	1	4	9
5	R:R:W117	R:R:Y198	50.654	4.82	Yes	Yes	1	9	4
6	R:R:I203	R:R:Y198	80.4844	4.84	No	Yes	0	6	4
7	R:R:I203	R:R:L276	96.4953	2.85	No	No	0	6	6
8	R:R:L276	R:R:T207	97.0117	4.42	No	No	0	6	5
9	R:R:L277	R:R:T207	97.5229	2.95	No	No	0	6	5
10	R:R:F273	R:R:L277	98.0288	7.31	Yes	No	0	6	6
11	R:R:F210	R:R:F273	99.5151	3.22	No	Yes	0	7	6
12	R:R:F210	R:R:W269	100	16.04	No	Yes	0	7	8
13	R:R:L128	R:R:W269	91.6826	7.97	No	Yes	0	6	8
14	R:R:L128	R:R:M124	91.1348	4.24	No	No	0	6	6
15	R:R:M124	R:R:Y98	90.5607	7.18	No	Yes	0	6	6
16	R:R:L102	R:R:Y98	11.6622	9.38	No	Yes	0	5	6
17	R:R:V298	R:R:Y98	12.3725	7.57	No	Yes	0	5	6
18	R:R:F52	R:R:V298	11.1248	22.28	Yes	No	0	6	5
19	R:R:C56	R:R:Y98	13.9506	4.03	Yes	Yes	0	5	6
20	R:R:V301	R:R:Y98	60.7224	5.05	No	Yes	0	7	6
21	R:R:I59	R:R:V301	59.9439	3.07	Yes	No	0	7	7
22	R:R:I59	R:R:N63	26.1842	4.25	Yes	Yes	3	7	9
23	R:R:D91	R:R:I59	28.1344	4.2	Yes	Yes	3	9	7
24	R:R:N63	R:R:P308	26.2969	4.89	Yes	No	3	9	9
25	R:R:D91	R:R:P308	25.4109	4.83	Yes	No	3	9	9
26	R:R:P308	R:R:V66	49.7864	7.07	No	No	0	9	9
27	R:R:T312	R:R:V66	42.0378	1.59	No	No	0	7	9
28	R:R:M318	R:R:T312	34.2054	7.53	Yes	No	0	8	7
29	R:R:K75	R:R:M318	26.234	2.88	Yes	Yes	4	6	8
30	R:R:K75	R:R:T73	16.2914	10.51	Yes	No	0	6	6
31	R:R:A321	R:R:T73	10.2205	5.03	No	No	0	7	6
32	R:R:F265	R:R:W269	59.3987	7.02	No	Yes	0	9	8
33	R:R:F265	R:R:L135	58.3449	4.87	No	No	0	9	9
34	R:R:L135	R:R:Y311	51.5688	4.69	No	Yes	0	9	9
35	R:R:I138	R:R:Y311	31.2511	3.63	Yes	Yes	5	8	9
36	R:R:F83	R:R:I138	60.0252	3.77	No	Yes	0	8	8
37	R:R:F83	R:R:I164	47.4351	5.02	No	Yes	0	8	7
38	R:R:I164	W:W:V45	61.6582	3.07	Yes	Yes	0	7	0
39	R:R:N303	R:R:W269	61.3253	12.43	No	Yes	0	9	8
40	R:R:N303	R:R:N307	60.6962	9.54	No	No	0	9	9
41	R:R:L87	R:R:N307	60.421	4.12	Yes	No	0	9	9
42	R:R:I138	R:R:L87	27.1252	2.85	Yes	Yes	5	8	9
43	R:R:L87	R:R:S134	35.1385	6.01	Yes	No	0	9	8
44	R:R:N86	R:R:S134	34.4989	7.45	Yes	No	0	9	8
45	R:R:I164	R:R:N86	22.4462	5.66	Yes	Yes	0	7	9
46	R:R:E141	R:R:F83	15.623	9.33	Yes	No	0	9	8
47	R:R:N86	R:R:W168	15.2376	10.17	Yes	Yes	0	9	9
48	R:R:A130	R:R:W168	12.6583	5.19	No	Yes	0	7	9
49	R:R:F118	R:R:N183	12.0763	9.67	Yes	No	0	6	5
50	R:R:Y198	R:R:Y202	11.6307	6.95	Yes	Yes	1	4	7
51	R:R:A130	R:R:S171	10.9125	3.42	No	No	0	7	8
52	R:R:A139	R:R:Y221	12.2651	4	No	Yes	0	8	9
53	R:R:Y221	R:R:Y311	21.7253	3.97	Yes	Yes	5	9	9
54	R:R:A139	R:R:L220	11.2716	3.15	No	No	0	8	7
55	R:R:L220	R:R:Y143	10.2729	7.03	No	Yes	0	7	8
56	R:R:F161	W:W:V45	48.7195	5.24	Yes	Yes	7	2	0
57	R:R:F161	W:W:V48	44.4415	2.62	Yes	No	0	2	0
58	R:R:V169	W:W:V48	42.2659	1.6	No	No	0	4	0
59	R:R:V169	W:W:T52	37.8988	7.93	No	No	0	4	0
60	R:R:S192	R:R:V194	15.117	3.23	No	Yes	0	4	4
61	R:R:I203	R:R:S192	15.9847	3.1	No	No	0	6	4
62	R:R:L290	R:R:V194	13.7304	4.47	Yes	Yes	1	3	4
63	R:R:V258	R:R:Y221	12.2651	3.79	No	Yes	0	8	9
64	W:W:I51	W:W:T52	35.7074	1.52	No	No	0	0	0
65	W:W:I51	W:W:I55	26.9312	2.94	No	No	0	0	0
66	W:W:I55	Z:Z:I54	24.711	4.42	No	No	0	0	0
67	W:W:L54	Z:Z:I54	22.5065	4.28	No	No	0	0	0
68	W:W:L54	Z:Z:D55	15.8091	1.36	No	No	0	0	0
69	Z:Z:D55	Z:Z:S56	11.3214	4.42	No	No	0	0	0
70	R:R:I25	R:R:W117	24.6376	4.7	Yes	Yes	1	4	9
71	R:R:P178	R:R:Y198	11.497	12.52	Yes	Yes	1	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P79	R:R:S155	5.34	6	No	No	7	7	2	2
R:R:N157	R:R:P79	3.26	6	No	No	1	7	1	2
R:R:F83	R:R:I164	5.02	0	No	Yes	8	7	2	1
R:R:I164	R:R:N86	5.66	0	Yes	Yes	7	9	1	2
R:R:F118	R:R:I179	6.28	1	Yes	No	6	5	2	1
R:R:F118	R:R:N183	9.67	1	Yes	No	6	5	2	2
R:R:L172	R:R:V126	4.47	0	No	No	4	5	1	2
R:R:N157	R:R:S155	5.96	6	No	No	1	7	1	2
R:R:N157	W:W:V41	4.43	6	No	No	1	0	1	0
R:R:I164	R:R:L160	5.71	0	Yes	No	7	7	1	2
R:R:F161	R:R:S165	9.25	7	Yes	No	2	4	1	1
R:R:F161	W:W:V45	5.24	7	Yes	Yes	2	0	1	0
R:R:I164	W:W:V45	3.07	0	Yes	Yes	7	0	1	0
R:R:S165	W:W:V45	3.23	7	No	Yes	4	0	1	0
R:R:V169	W:W:T52	7.93	0	No	No	4	0	1	0
R:R:I179	W:W:A60	3.25	0	No	No	5	0	1	0
R:R:M180	W:W:I56	5.83	0	No	No	4	0	1	0
R:R:M180	W:W:I59	10.2	0	No	No	4	0	1	0
R:R:G181	R:R:N183	5.09	0	No	No	5	5	1	2
R:R:L177	R:R:M180	2.83	0	No	No	5	4	2	1
R:R:F161	W:W:A44	2.77	7	Yes	No	2	0	1	0
R:R:F161	W:W:V48	2.62	7	Yes	No	2	0	1	0
R:R:G181	W:W:V63	1.84	0	No	No	5	0	1	0
R:R:V169	W:W:V48	1.6	0	No	No	4	0	1	0
R:R:I173	R:R:V169	1.54	0	No	No	4	4	2	1
R:R:L172	W:W:V49	1.49	0	No	No	4	0	1	0
R:R:L172	W:W:I53	1.43	0	No	No	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8G94_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	312
Number of Links	342
Number of Hubs	43
Number of Links mediated by Hubs	158
Number of Communities	7
Number of Nodes involved in Communities	46
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	80969
Length Of Smallest Path	3
Average Path Length	17.5838
Length of Longest Path	38
Minimum Path Strength	1.43
Average Path Strength	5.47399
Maximum Path Strength	15.03
Minimum Path Correlation	0.7
Average Path Correlation	0.948426
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	48.4663
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.3219
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • response to stimulus • regulation of alpha-beta T cell activation • regulation of leukocyte activation • regulation of cell activation • regulation of cell development • alpha-beta T cell differentiation involved in immune response • negative regulation of cell adhesion • negative regulation of cell fate commitment • multicellular organism development • negative regulation of T cell differentiation • T cell activation • cell differentiation • regulation of T-helper cell differentiation • alpha-beta T cell activation • regulation of immune system process • immune response • T-helper cell differentiation • alpha-beta T cell lineage commitment • negative regulation of leukocyte differentiation • negative regulation of immune effector process • immune effector process • negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • negative regulation of T-helper 17 cell lineage commitment • regulation of response to stimulus • negative regulation of T cell activation • negative regulation of leukocyte cell-cell adhesion • negative regulation of cell-cell adhesion • regulation of leukocyte cell-cell adhesion • negative regulation of multicellular organismal process • T-helper 17 cell differentiation • cell fate commitment • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment • regulation of developmental process • cell development • negative regulation of T-helper 17 cell differentiation • CD4-positive, alpha-beta T cell differentiation • regulation of T cell differentiation • alpha-beta T cell differentiation • T cell activation involved in immune response • leukocyte activation involved in immune response • negative regulation of cell differentiation • regulation of cell-cell adhesion • regulation of T-helper 17 cell differentiation • hemopoiesis • negative regulation of developmental process • regulation of cell adhesion • cell activation • negative regulation of T-helper 17 type immune response • negative regulation of cell development • regulation of CD4-positive, alpha-beta T cell activation • immune system process • cellular process • negative regulation of alpha-beta T cell activation • regulation of lymphocyte activation • regulation of immune effector process • multicellular organismal process • regulation of leukocyte differentiation • regulation of cellular process • negative regulation of biological process • mononuclear cell differentiation • regulation of cell differentiation • lymphocyte differentiation • cell activation involved in immune response • CD4-positive, alpha-beta T cell differentiation involved in immune response • anatomical structure development • T cell differentiation • CD4-positive, alpha-beta T cell lineage commitment • negative regulation of hemopoiesis • developmental process • regulation of biological process • regulation of adaptive immune response • negative regulation of immune response • T-helper cell lineage commitment • negative regulation of adaptive immune response • T-helper 17 cell lineage commitment • negative regulation of CD4-positive, alpha-beta T cell activation • negative regulation of lymphocyte differentiation • regulation of immune response • negative regulation of CD4-positive, alpha-beta T cell differentiation • negative regulation of leukocyte activation • leukocyte differentiation • cellular developmental process • regulation of CD4-positive, alpha-beta T cell differentiation • regulation of alpha-beta T cell differentiation • lymphocyte activation • negative regulation of alpha-beta T cell differentiation • negative regulation of lymphocyte activation • leukocyte cell-cell adhesion • leukocyte activation • cell adhesion • regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • cell-cell adhesion • alpha-beta T cell activation involved in immune response • CD4-positive, alpha-beta T cell activation • negative regulation of cellular process • regulation of multicellular organismal process • lymphocyte activation involved in immune response • regulation of lymphocyte differentiation • regulation of multicellular organismal development • regulation of T-helper 17 cell lineage commitment • regulation of T-helper 17 type immune response • negative regulation of response to stimulus • regulation of cell fate commitment • biological regulation • regulation of T cell activation • T cell differentiation involved in immune response • T cell lineage commitment • adaptive immune response • negative regulation of T-helper cell differentiation • negative regulation of cell activation • negative regulation of immune system process • positive T cell selection • regulation of hemopoiesis • T cell selection • T-helper 17 type immune response • cellular response to stimulus • cellular response to chemical stimulus • response to chemical • cellular response to xenobiotic stimulus • response to xenobiotic stimulus • negative regulation of mononuclear cell migration • negative regulation of locomotion • regulation of cell motility • regulation of lymphocyte migration • regulation of cell migration • cell migration • negative regulation of lymphocyte migration • cell motility • regulation of mononuclear cell migration • locomotion • negative regulation of cell migration • regulation of leukocyte migration • lymphocyte migration • leukocyte migration • negative regulation of T cell migration • negative regulation of leukocyte migration • regulation of locomotion • regulation of T cell migration • mononuclear cell migration • negative regulation of cell motility • T cell migration • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • protein-containing complex • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • sphingolipid binding • lipid binding • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • head development • central nervous system development • brain development • nervous system development • lamellipodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component biogenesis • cellular component assembly • lamellipodium organization • cell projection assembly • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of actin filament-based process • regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • stress fiber assembly • negative regulation of supramolecular fiber organization • regulation of actin filament organization • negative regulation of stress fiber assembly • actin cytoskeleton organization • actomyosin structure organization • negative regulation of cellular component organization • negative regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • negative regulation of actin filament bundle assembly • regulation of stress fiber assembly • negative regulation of organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • heart trabecula morphogenesis • trabecula morphogenesis • generation of neurons • neurogenesis • neuron differentiation • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • homeostatic process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • bone mineralization • regulation of biomineral tissue development • regulation of bone mineralization • ossification • biomineral tissue development • regulation of ossification • chemotaxis • taxis • response to external stimulus • positive chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • transmission of nerve impulse • positive regulation of cell migration • positive regulation of cell motility • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • developmental growth • heart morphogenesis • organ growth • striated muscle tissue development • muscle structure development • cardiac muscle tissue growth involved in heart morphogenesis • animal organ morphogenesis • cardiac muscle tissue growth • muscle tissue development • muscle organ development • heart development • heart growth • cardiac muscle tissue development • growth • muscle tissue morphogenesis • developmental growth involved in morphogenesis • tissue morphogenesis • cardiac muscle tissue morphogenesis • growth involved in heart morphogenesis • muscle organ morphogenesis • cell chemotaxis • leukocyte chemotaxis • sphingolipid mediated signaling pathway • sphingosine-1-phosphate receptor signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • blood vessel maturation • developmental maturation • anatomical structure maturation • membrane microdomain • membrane raft • presynapse • endosome • intracellular vesicle • cytoplasmic vesicle
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>8G94_nogp_Chain_R V N Y D I I V R H Y N Y T G K L N I K L T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F R K K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	doi.org/10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	doi.org/10.7554/eLife.88204
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	doi.org/10.1038/s41589-021-00930-3
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	doi.org/10.1073/pnas.2117716119
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	doi.org/10.1126/science.1215904
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	doi.org/10.1126/science.1215904
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published

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