psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y29	7.15	Yes	Yes	0	0	7
2	L:L:?1	R:R:N101	13.15	Yes	No	0	0	5
3	L:L:?1	R:R:S105	13.08	Yes	No	0	0	4
4	L:L:?1	R:R:T109	3.85	Yes	No	0	0	5
5	L:L:?1	R:R:E121	8.08	Yes	Yes	1	0	5
6	L:L:?1	R:R:F125	14.85	Yes	No	0	0	5
7	L:L:?1	R:R:L128	8.44	Yes	No	1	0	6
8	L:L:?1	R:R:S129	5.23	Yes	No	0	0	6
9	L:L:?1	R:R:W269	5.95	Yes	Yes	1	0	8
10	L:L:?1	R:R:L272	8.44	Yes	No	1	0	6
11	L:L:?1	R:R:L297	12.05	Yes	No	0	0	5
12	R:R:H28	R:R:I24	5.3	Yes	No	0	8	4
13	R:R:I25	R:R:L197	4.28	No	Yes	0	4	4
14	R:R:H28	R:R:R27	7.9	Yes	No	0	8	3
15	R:R:R27	R:R:Y31	5.14	No	No	0	3	5
16	R:R:C184	R:R:H28	5.9	No	Yes	0	5	8
17	R:R:H28	R:R:L197	7.71	Yes	Yes	0	8	4
18	R:R:K34	R:R:Y29	8.36	No	Yes	0	6	7
19	R:R:Y110	R:R:Y29	3.97	No	Yes	0	5	7
20	R:R:W117	R:R:Y29	4.82	Yes	Yes	0	9	7
21	R:R:P196	R:R:Y29	15.3	No	Yes	0	3	7
22	R:R:L188	R:R:Y31	8.21	No	No	0	2	5
23	R:R:P196	R:R:T32	10.49	No	No	0	3	8
24	R:R:G33	R:R:K285	5.23	No	No	0	7	2
25	R:R:N36	R:R:Y110	8.14	No	No	0	4	5
26	R:R:F52	R:R:T48	3.89	Yes	No	0	6	5
27	R:R:F52	R:R:V51	3.93	Yes	No	0	6	5
28	R:R:F52	R:R:Y295	4.13	Yes	No	0	6	3
29	R:R:F52	R:R:V298	14.42	Yes	No	0	6	5
30	R:R:I53	R:R:T99	4.56	Yes	No	0	3	6
31	R:R:I53	R:R:L102	5.71	Yes	No	0	3	5
32	R:R:I53	R:R:L103	4.28	Yes	No	0	3	6
33	R:R:C56	R:R:Y98	5.38	No	Yes	0	5	6
34	R:R:C56	R:R:T99	5.07	No	No	0	5	6
35	R:R:E62	R:R:F58	12.83	No	No	0	8	4
36	R:R:I59	R:R:N63	4.25	No	Yes	0	7	9
37	R:R:G305	R:R:I59	7.05	No	No	0	7	7
38	R:R:I60	R:R:L92	4.28	No	No	0	6	6
39	R:R:E62	R:R:I309	8.2	No	No	0	8	6
40	R:R:D91	R:R:N63	6.73	Yes	Yes	0	9	9
41	R:R:L92	R:R:N63	9.61	No	Yes	0	6	9
42	R:R:N63	R:R:P308	6.52	Yes	No	0	9	9
43	R:R:I64	R:R:L92	4.28	No	No	0	4	6
44	R:R:K75	R:R:T73	4.5	No	No	2	6	6
45	R:R:F76	R:R:T73	16.86	Yes	No	2	8	6
46	R:R:F76	R:R:K75	3.72	Yes	No	2	8	6
47	R:R:E317	R:R:K75	16.2	Yes	No	2	7	6
48	R:R:F76	R:R:Y81	24.76	Yes	Yes	2	8	9
49	R:R:E317	R:R:F76	7	Yes	Yes	2	7	8
50	R:R:H77	R:R:Y82	4.36	No	No	0	7	4
51	R:R:M80	R:R:R78	3.72	Yes	No	0	8	7
52	R:R:R78	R:R:Y81	15.43	No	Yes	0	7	9
53	R:R:P79	R:R:S155	7.13	No	No	0	7	7
54	R:R:L160	R:R:P79	6.57	Yes	No	0	7	7
55	R:R:F83	R:R:M80	3.73	Yes	Yes	1	8	8
56	R:R:I138	R:R:M80	4.37	Yes	Yes	1	8	8
57	R:R:E141	R:R:M80	5.41	Yes	Yes	1	9	8
58	R:R:N315	R:R:Y81	4.65	No	Yes	2	8	9
59	R:R:E317	R:R:Y81	8.98	Yes	Yes	2	7	9
60	R:R:L160	R:R:Y82	5.86	Yes	No	0	7	4
61	R:R:E141	R:R:F83	13.99	Yes	Yes	1	9	8
62	R:R:F83	R:R:L160	8.53	Yes	Yes	1	8	7
63	R:R:F83	R:R:L163	7.31	Yes	No	0	8	6
64	R:R:F83	R:R:I164	3.77	Yes	No	1	8	7
65	R:R:N86	R:R:S90	4.47	No	No	0	9	8
66	R:R:I164	R:R:N86	8.5	No	No	0	7	9
67	R:R:N86	R:R:W168	7.91	No	No	0	9	9
68	R:R:D91	R:R:L87	8.14	Yes	Yes	1	9	9
69	R:R:L87	R:R:S134	7.51	Yes	No	0	9	8
70	R:R:I138	R:R:L87	4.28	Yes	Yes	1	8	9
71	R:R:L87	R:R:N307	6.87	Yes	Yes	1	9	9
72	R:R:L87	R:R:Y311	7.03	Yes	Yes	1	9	9
73	R:R:L89	R:R:L93	6.92	No	No	0	5	6
74	R:R:S134	R:R:S90	4.89	No	No	0	8	8
75	R:R:D91	R:R:S131	4.42	Yes	No	0	9	9
76	R:R:D91	R:R:S304	7.36	Yes	No	0	9	9
77	R:R:D91	R:R:N307	10.77	Yes	Yes	1	9	9
78	R:R:L102	R:R:Y98	21.1	No	Yes	0	5	6
79	R:R:M124	R:R:Y98	5.99	Yes	Yes	0	6	6
80	R:R:V298	R:R:Y98	5.05	No	Yes	0	5	6
81	R:R:V301	R:R:Y98	10.09	No	Yes	0	7	6
82	R:R:N101	R:R:R120	7.23	No	Yes	0	5	6
83	R:R:M124	R:R:N101	11.22	Yes	No	0	6	5
84	R:R:L104	R:R:R120	8.5	No	Yes	0	4	6
85	R:R:T109	R:R:Y110	3.75	No	No	0	5	5
86	R:R:R120	R:R:T109	7.76	Yes	No	0	6	5
87	R:R:L112	R:R:Q116	15.97	No	No	0	5	4
88	R:R:L112	R:R:R120	7.29	No	Yes	0	5	6
89	R:R:Q116	R:R:T113	4.25	No	No	0	4	7
90	R:R:F118	R:R:W117	5.01	Yes	Yes	1	6	9
91	R:R:R120	R:R:W117	8	Yes	Yes	1	6	9
92	R:R:E121	R:R:W117	22.9	Yes	Yes	1	5	9
93	R:R:L195	R:R:W117	4.56	Yes	Yes	1	3	9
94	R:R:L197	R:R:W117	10.25	Yes	Yes	1	4	9
95	R:R:W117	R:R:Y198	4.82	Yes	Yes	1	9	4
96	R:R:F118	R:R:P178	4.33	Yes	Yes	1	6	5
97	R:R:F118	R:R:I179	6.28	Yes	No	0	6	5
98	R:R:F118	R:R:N183	8.46	Yes	No	0	6	5
99	R:R:F118	R:R:L197	6.09	Yes	Yes	1	6	4
100	R:R:E121	R:R:R120	5.82	Yes	Yes	1	5	6
101	R:R:E121	R:R:L195	3.98	Yes	Yes	1	5	3
102	R:R:L297	R:R:M124	4.24	No	Yes	0	5	6
103	R:R:F125	R:R:Y198	9.28	No	Yes	0	5	4
104	R:R:L172	R:R:V126	5.96	No	No	0	4	5
105	R:R:L128	R:R:W269	6.83	No	Yes	1	6	8
106	R:R:L174	R:R:S129	4.5	No	No	0	5	6
107	R:R:A130	R:R:W168	3.89	No	No	0	7	9
108	R:R:L213	R:R:V132	4.47	No	No	0	8	7
109	R:R:F265	R:R:V132	3.93	Yes	No	0	9	7
110	R:R:C167	R:R:F133	5.59	No	Yes	0	6	5
111	R:R:F133	R:R:I170	7.54	Yes	No	0	5	4
112	R:R:F133	R:R:S171	3.96	Yes	No	0	5	8
113	R:R:F133	R:R:L213	13.4	Yes	No	0	5	8
114	R:R:F265	R:R:L135	4.87	Yes	No	0	9	9
115	R:R:L135	R:R:N307	5.49	No	Yes	0	9	9
116	R:R:I140	R:R:L136	7.14	No	Yes	0	6	7
117	R:R:L136	R:R:L213	6.92	Yes	No	0	7	8
118	R:R:I217	R:R:L136	5.71	No	Yes	0	8	7
119	R:R:I138	R:R:R142	6.26	Yes	No	1	8	9
120	R:R:I138	R:R:Y311	7.25	Yes	Yes	1	8	9
121	R:R:A139	R:R:Y221	5.34	No	Yes	0	8	9
122	R:R:E141	R:R:T145	4.23	Yes	No	0	9	8
123	R:R:E141	R:R:R159	5.82	Yes	No	0	9	5
124	R:R:R142	R:R:Y221	8.23	No	Yes	1	9	9
125	R:R:R142	R:R:Y311	8.23	No	Yes	1	9	9
126	R:R:L147	R:R:Y143	4.69	No	Yes	0	6	8
127	R:R:L220	R:R:Y143	4.69	No	Yes	0	7	8
128	R:R:R223	R:R:Y143	6.17	No	Yes	0	5	8
129	R:R:I224	R:R:Y143	6.04	No	Yes	0	9	8
130	R:R:I144	R:R:R159	13.78	No	No	0	4	5
131	R:R:N153	R:R:T145	5.85	No	No	0	4	8
132	R:R:M149	R:R:R231	11.17	No	No	0	8	7
133	R:R:H152	R:R:L151	3.86	No	No	0	7	4
134	R:R:N157	R:R:S155	5.96	No	No	0	1	7
135	R:R:N156	R:R:R159	13.26	No	No	0	7	5
136	R:R:F161	R:R:N157	4.83	No	No	0	2	1
137	R:R:I164	R:R:L160	4.28	No	Yes	1	7	7
138	R:R:L174	R:R:V209	4.47	No	No	0	5	5
139	R:R:L177	R:R:W182	5.69	No	Yes	1	5	5
140	R:R:L177	R:R:Y202	5.86	No	Yes	1	5	7
141	R:R:P178	R:R:Y198	12.52	Yes	Yes	1	5	4
142	R:R:P178	R:R:Y202	13.91	Yes	Yes	1	5	7
143	R:R:H199	R:R:W182	6.35	Yes	Yes	0	4	5
144	R:R:W182	R:R:Y202	11.58	Yes	Yes	1	5	7
145	R:R:F205	R:R:W182	8.02	No	Yes	0	5	5
146	R:R:I185	R:R:N183	12.74	No	No	0	3	5
147	R:R:C184	R:R:C191	7.28	No	No	0	5	9
148	R:R:H199	R:R:S190	9.76	Yes	No	0	4	4
149	R:R:D279	R:R:S192	4.42	Yes	No	0	4	4
150	R:R:L290	R:R:T193	5.9	Yes	No	0	3	5
151	R:R:D279	R:R:V194	4.38	Yes	No	0	4	4
152	R:R:L195	R:R:Y198	9.38	Yes	Yes	1	3	4
153	R:R:Y198	R:R:Y202	6.95	Yes	Yes	1	4	7
154	R:R:H199	R:R:H201	9.55	Yes	No	0	4	4
155	R:R:C206	R:R:Y202	9.41	No	Yes	0	6	7
156	R:R:D279	R:R:I203	8.4	Yes	No	0	4	6
157	R:R:L204	R:R:V280	11.92	No	Yes	0	5	4
158	R:R:F205	R:R:V209	7.87	No	No	0	5	5
159	R:R:F273	R:R:T207	3.89	Yes	No	0	6	5
160	R:R:F210	R:R:W269	12.03	No	Yes	0	7	8
161	R:R:F210	R:R:F273	7.5	No	Yes	0	7	6
162	R:R:L262	R:R:V218	5.96	No	No	0	7	4
163	R:R:L262	R:R:Y221	4.69	No	Yes	0	7	9
164	R:R:Y221	R:R:Y311	3.97	Yes	Yes	1	9	9
165	R:R:R229	R:R:Y225	8.23	No	No	3	5	6
166	R:R:S251	R:R:Y225	3.82	No	No	3	7	6
167	R:R:L255	R:R:Y225	18.76	No	No	0	8	6
168	R:R:L227	R:R:R231	4.86	No	No	0	6	7
169	R:R:L254	R:R:V228	4.47	No	Yes	0	8	8
170	R:R:R229	R:R:R233	12.79	No	No	0	5	4
171	R:R:R229	R:R:S251	3.95	No	No	3	5	7
172	R:R:R231	R:R:R234	4.26	No	No	0	7	4
173	R:R:F237	R:R:L235	6.09	No	No	0	3	6
174	R:R:E249	R:R:L252	3.98	No	No	0	5	5
175	R:R:I259	R:R:L255	7.14	No	No	0	5	8
176	R:R:T257	R:R:T314	4.71	No	No	0	9	7
177	R:R:I310	R:R:V264	4.61	Yes	No	0	8	7
178	R:R:F265	R:R:W269	8.02	Yes	Yes	1	9	8
179	R:R:F265	R:R:N303	6.04	Yes	Yes	1	9	9
180	R:R:C268	R:R:N303	7.87	No	Yes	0	8	9
181	R:R:L272	R:R:W269	5.69	No	Yes	1	6	8
182	R:R:N303	R:R:W269	6.78	Yes	Yes	1	9	8
183	R:R:F296	R:R:P271	5.78	No	No	0	4	9
184	R:R:F273	R:R:L277	7.31	Yes	No	0	6	6
185	R:R:F296	R:R:L275	7.31	No	No	0	4	4
186	R:R:C282	R:R:L278	4.76	No	No	0	4	4
187	R:R:D279	R:R:V280	4.38	Yes	Yes	0	4	4
188	R:R:D279	R:R:L290	4.07	Yes	Yes	0	4	3
189	R:R:C282	R:R:C287	7.28	No	No	0	4	3
190	R:R:K283	R:R:T286	4.5	No	No	0	1	1
191	R:R:C287	R:R:L290	4.76	No	Yes	0	3	3
192	R:R:I289	R:R:R292	3.76	No	No	0	3	4
193	R:R:E294	R:R:Y295	14.59	No	No	0	3	3
194	R:R:L302	R:R:V298	4.47	No	No	0	6	5
195	R:R:N303	R:R:N307	5.45	Yes	Yes	1	9	9
196	R:R:M318	R:R:T312	6.02	No	No	0	8	7
197	R:R:E317	R:R:N315	3.94	Yes	No	2	7	8
198	R:R:M318	R:R:N315	8.41	No	No	0	8	8
199	R:R:K316	R:R:R319	7.43	No	No	0	6	8
200	R:R:R320	R:R:R324	5.33	No	No	0	5	4
201	R:R:P114	R:R:T113	3.5	No	No	0	3	7
202	R:R:L93	R:R:W168	3.42	No	No	0	6	9
203	R:R:A94	R:R:S304	3.42	No	No	0	8	9
204	R:R:A97	R:R:S123	3.42	No	No	0	4	4
205	R:R:A88	R:R:V66	3.39	No	No	0	9	9
206	R:R:C287	R:R:T286	3.38	No	No	0	3	1
207	R:R:L299	R:R:P271	3.28	No	No	0	7	9
208	R:R:A88	R:R:L67	3.15	No	No	0	9	8
209	R:R:A139	R:R:L220	3.15	No	No	0	8	7
210	R:R:T208	R:R:T211	3.14	No	No	4	4	4
211	R:R:I60	R:R:V96	3.07	No	No	0	6	5
212	R:R:M124	R:R:S123	3.07	Yes	No	0	6	4
213	R:R:K200	R:R:V280	3.04	No	Yes	0	3	4
214	R:R:I309	R:R:T306	3.04	No	No	0	6	5
215	R:R:F291	R:R:G33	3.01	No	No	0	1	7
216	R:R:L102	R:R:S49	3	No	No	0	5	5
217	R:R:L195	R:R:V194	2.98	Yes	No	0	3	4
218	R:R:L214	R:R:V218	2.98	No	No	0	5	4
219	R:R:L227	R:R:V228	2.98	No	Yes	0	6	8
220	R:R:L254	R:R:V258	2.98	No	No	0	8	8
221	R:R:L68	R:R:T69	2.95	No	No	0	4	8
222	R:R:L313	R:R:T312	2.95	No	No	0	6	7
223	R:R:I55	R:R:I59	2.94	No	No	0	6	7
224	R:R:I70	R:R:I84	2.94	No	No	0	7	8
225	R:R:A187	R:R:H199	2.93	No	Yes	0	4	4
226	R:R:I84	R:R:M80	2.92	No	Yes	0	8	8
227	R:R:I203	R:R:L276	2.85	No	No	0	6	6
228	R:R:I266	R:R:L262	2.85	No	No	0	6	7
229	R:R:I309	R:R:L313	2.85	No	No	0	6	6
230	R:R:K72	R:R:L68	2.82	No	No	0	6	4
231	R:R:A321	R:R:F76	2.77	No	Yes	0	7	8
232	R:R:A137	R:R:F83	2.77	No	Yes	0	7	8
233	R:R:L275	R:R:L290	2.77	No	Yes	0	4	3
234	R:R:L35	R:R:N30	2.75	No	No	0	6	9
235	R:R:R223	R:R:S226	2.64	No	No	0	5	3
236	R:R:F322	R:R:T69	2.59	No	No	0	7	8
237	R:R:F273	R:R:T211	2.59	Yes	No	0	6	4
238	R:R:R233	R:R:T230	2.59	No	No	0	4	5
239	R:R:A300	R:R:W269	2.59	No	Yes	0	7	8
240	R:R:V258	R:R:Y221	2.52	No	Yes	0	8	9
241	R:R:F273	R:R:I274	2.51	Yes	No	0	6	5
242	R:R:F296	R:R:I289	2.51	No	No	0	4	3
243	R:R:I323	R:R:R324	2.51	No	No	0	3	4
244	R:R:F291	R:R:K34	2.48	No	No	0	1	6
245	R:R:F158	R:R:L162	2.44	No	No	0	4	3
246	R:R:L313	R:R:R319	2.43	No	No	0	6	8
247	R:R:I310	R:R:Y311	2.42	Yes	Yes	0	8	9
248	R:R:D288	R:R:F291	2.39	No	No	0	3	1
249	R:R:N30	R:R:Y31	2.33	No	No	0	9	5
250	R:R:F322	R:R:F65	2.14	No	No	0	7	7
251	R:R:G175	R:R:G176	2.11	No	No	0	6	4
252	R:R:G176	R:R:P178	2.03	No	Yes	0	4	5
253	R:R:A88	R:R:G85	1.95	No	No	0	9	5
254	R:R:A94	R:R:G95	1.95	No	No	0	8	7
255	R:R:A270	R:R:P271	1.87	No	No	0	6	9
256	R:R:G106	R:R:S105	1.86	No	No	0	4	4
257	R:R:G175	R:R:V126	1.84	No	No	0	6	5
258	R:R:G281	R:R:V280	1.84	No	Yes	0	4	4
259	R:R:A127	R:R:A94	1.79	No	No	0	6	8
260	R:R:A127	R:R:A97	1.79	No	No	0	6	4
261	R:R:P308	R:R:V66	1.77	No	No	0	9	9
262	R:R:G176	R:R:M180	1.75	No	No	0	4	4
263	R:R:C222	R:R:V218	1.71	No	No	0	3	4
264	R:R:G154	R:R:N153	1.7	No	No	0	4	4
265	R:R:G181	R:R:N183	1.7	No	No	0	5	5
266	R:R:A293	R:R:V194	1.7	No	No	0	4	4
267	R:R:A321	R:R:T69	1.68	No	No	0	7	8
268	R:R:A115	R:R:T113	1.68	No	No	0	2	7
269	R:R:C57	R:R:I53	1.64	No	Yes	0	5	3
270	R:R:A166	R:R:I170	1.62	No	No	0	3	4
271	R:R:S232	R:R:V228	1.62	No	Yes	0	5	8
272	R:R:S263	R:R:V264	1.62	No	No	0	5	7
273	R:R:S226	R:R:T230	1.6	No	No	0	3	5
274	R:R:T193	R:R:V284	1.59	No	No	0	5	1
275	R:R:T257	R:R:V261	1.59	No	No	0	9	8
276	R:R:I173	R:R:V169	1.54	No	No	0	4	4
277	R:R:I310	R:R:V261	1.54	Yes	No	0	8	8
278	R:R:M146	R:R:V228	1.52	No	Yes	0	8	8
279	R:R:F125	R:R:G122	1.51	No	No	0	5	6
280	R:R:K111	R:R:T108	1.5	No	No	0	1	4
281	R:R:L136	R:R:S216	1.5	Yes	No	0	7	6
282	R:R:L54	R:R:V50	1.49	No	No	0	4	5
283	R:R:L112	R:R:T108	1.47	No	No	0	5	4
284	R:R:L212	R:R:T208	1.47	No	No	4	5	4
285	R:R:L212	R:R:T211	1.47	No	No	4	5	4
286	R:R:I260	R:R:I310	1.47	No	Yes	0	6	8
287	R:R:I260	R:R:K256	1.45	No	No	0	6	7
288	R:R:K148	R:R:K150	1.44	No	No	0	6	7
289	R:R:E249	R:R:S251	1.44	No	No	0	5	7
290	R:R:I179	R:R:L119	1.43	No	No	0	5	4
291	R:R:I173	R:R:L177	1.43	No	No	0	4	5
292	R:R:K150	R:R:N153	1.4	No	No	0	7	4
293	R:R:I219	R:R:R223	1.25	No	No	0	4	5
294	R:R:F158	R:R:N156	1.21	No	No	0	4	7
295	R:R:K72	R:R:W71	1.16	No	No	0	6	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.11545	11	1	0
2	R:R:H28	6.7025	4	0	8
3	R:R:Y29	7.92	5	0	7
4	R:R:F52	6.5925	4	0	6
5	R:R:I53	4.0475	4	0	3
6	R:R:N63	6.7775	4	0	9
7	R:R:F76	11.022	5	2	8
8	R:R:M80	4.03	5	1	8
9	R:R:Y81	13.455	4	2	9
10	R:R:F83	6.68333	6	1	8
11	R:R:L87	6.766	5	1	9
12	R:R:D91	7.484	5	1	9
13	R:R:Y98	9.522	5	0	6
14	R:R:W117	8.62286	7	1	9
15	R:R:F118	6.034	5	1	6
16	R:R:R120	7.43333	6	1	6
17	R:R:E121	10.195	4	1	5
18	R:R:M124	6.13	4	0	6
19	R:R:F133	7.6225	4	0	5
20	R:R:L136	5.3175	4	0	7
21	R:R:I138	5.54	4	1	8
22	R:R:E141	7.3625	4	1	9
23	R:R:Y143	5.3975	4	0	8
24	R:R:L160	6.31	4	1	7
25	R:R:P178	8.1975	4	1	5
26	R:R:W182	7.91	4	1	5
27	R:R:L195	5.225	4	1	3
28	R:R:L197	7.0825	4	1	4
29	R:R:Y198	8.59	5	1	4
30	R:R:H199	7.1475	4	0	4
31	R:R:Y202	9.542	5	1	7
32	R:R:Y221	4.95	5	1	9
33	R:R:V228	2.6475	4	0	8
34	R:R:F265	5.715	4	1	9
35	R:R:W269	6.84143	7	1	8
36	R:R:F273	4.76	5	0	6
37	R:R:D279	5.13	5	0	4
38	R:R:V280	5.295	4	0	4
39	R:R:L290	4.375	4	0	3
40	R:R:N303	6.535	4	1	9
41	R:R:N307	7.145	4	1	9
42	R:R:I310	2.51	4	0	8
43	R:R:Y311	5.78	5	1	9
44	R:R:E317	9.03	4	2	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y29	19.9249	7.15	Yes	Yes	0	0	7
2	R:R:W117	R:R:Y29	14.6017	4.82	Yes	Yes	0	9	7
3	R:R:L197	R:R:W117	18.1392	10.25	Yes	Yes	1	4	9
4	R:R:H28	R:R:L197	15.8766	7.71	Yes	Yes	0	8	4
5	L:L:?1	R:R:E121	39.8244	8.08	Yes	Yes	1	0	5
6	R:R:E121	R:R:W117	11.5834	22.9	Yes	Yes	1	5	9
7	L:L:?1	R:R:N101	23.437	13.15	Yes	No	0	0	5
8	R:R:M124	R:R:N101	26.755	11.22	Yes	No	0	6	5
9	R:R:M124	R:R:Y98	37.2789	5.99	Yes	Yes	0	6	6
10	R:R:V298	R:R:Y98	16.5731	5.05	No	Yes	0	5	6
11	R:R:F52	R:R:V298	11.8789	14.42	Yes	No	0	6	5
12	L:L:?1	R:R:L297	17.9746	12.05	Yes	No	0	0	5
13	R:R:L297	R:R:M124	16.9488	4.24	No	Yes	0	5	6
14	R:R:L102	R:R:Y98	11.8452	21.1	No	Yes	0	5	6
15	L:L:?1	R:R:W269	100	5.95	Yes	Yes	1	0	8
16	R:R:N303	R:R:W269	89.856	6.78	Yes	Yes	1	9	8
17	R:R:N303	R:R:N307	95.5549	5.45	Yes	Yes	1	9	9
18	R:R:L87	R:R:N307	87.1164	6.87	Yes	Yes	1	9	9
19	R:R:I138	R:R:L87	48.6724	4.28	Yes	Yes	1	8	9
20	R:R:I138	R:R:M80	61.7797	4.37	Yes	Yes	1	8	8
21	R:R:M80	R:R:R78	33.4755	3.72	Yes	No	0	8	7
22	R:R:R78	R:R:Y81	32.1584	15.43	No	Yes	0	7	9
23	R:R:N315	R:R:Y81	14.4751	4.65	No	Yes	2	8	9
24	R:R:M318	R:R:N315	13.635	8.41	No	No	0	8	8
25	R:R:M318	R:R:T312	12.1533	6.02	No	No	0	8	7
26	R:R:L313	R:R:T312	10.6632	2.95	No	No	0	6	7
27	R:R:D91	R:R:N307	14.7748	10.77	Yes	Yes	1	9	9
28	R:R:D91	R:R:N63	18.2152	6.73	Yes	Yes	0	9	9
29	R:R:F76	R:R:Y81	14.4286	24.76	Yes	Yes	2	8	9
30	R:R:F83	R:R:M80	16.0117	3.73	Yes	Yes	1	8	8
31	R:R:F83	R:R:L160	10.1313	8.53	Yes	Yes	1	8	7
32	R:R:E141	R:R:M80	14.9732	5.41	Yes	Yes	1	9	8
33	R:R:L87	R:R:Y311	40.8249	7.03	Yes	Yes	1	9	9
34	R:R:N101	R:R:R120	16.2143	7.23	No	Yes	0	5	6
35	R:R:L112	R:R:R120	17.7255	7.29	No	Yes	0	5	6
36	R:R:L112	R:R:Q116	10.1777	15.97	No	No	0	5	4
37	R:R:F118	R:R:W117	10.4943	5.01	Yes	Yes	1	6	9
38	L:L:?1	R:R:F125	16.1763	14.85	Yes	No	0	0	5
39	R:R:F125	R:R:Y198	14.8212	9.28	No	Yes	0	5	4
40	R:R:F265	R:R:V132	19.9164	3.93	Yes	No	0	9	7
41	R:R:L213	R:R:V132	18.1477	4.47	No	No	0	8	7
42	R:R:Y221	R:R:Y311	38.7564	3.97	Yes	Yes	1	9	9
43	R:R:A139	R:R:Y221	25.4549	5.34	No	Yes	0	8	9
44	R:R:A139	R:R:L220	24.0069	3.15	No	No	0	8	7
45	R:R:L220	R:R:Y143	22.5506	4.69	No	Yes	0	7	8
46	R:R:R223	R:R:Y143	18.1223	6.17	No	Yes	0	5	8
47	R:R:V258	R:R:Y221	13.3606	2.52	No	Yes	0	8	9
48	R:R:L254	R:R:V258	12.014	2.98	No	No	0	8	8
49	R:R:L254	R:R:V228	10.4817	4.47	No	Yes	0	8	8
50	R:R:Y198	R:R:Y202	12.4319	6.95	Yes	Yes	1	4	7
51	R:R:E121	R:R:L195	25.5435	3.98	Yes	Yes	1	5	3
52	R:R:L195	R:R:V194	33.3024	2.98	Yes	No	0	3	4
53	R:R:D279	R:R:V194	30.9342	4.38	Yes	No	0	4	4
54	R:R:D279	R:R:L290	20.7649	4.07	Yes	Yes	0	4	3
55	R:R:F210	R:R:W269	10.5323	12.03	No	Yes	0	7	8
56	R:R:R223	R:R:S226	15.1336	2.64	No	No	0	5	3
57	R:R:S226	R:R:T230	13.6266	1.6	No	No	0	3	5
58	R:R:R233	R:R:T230	12.1111	2.59	No	No	0	4	5
59	R:R:R229	R:R:R233	10.5872	12.79	No	No	0	5	4
60	R:R:I310	R:R:Y311	10.4901	2.42	Yes	Yes	0	8	9
61	R:R:A321	R:R:F76	10.4817	2.77	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y29	7.15	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N101	13.15	1	Yes	No	0	5	0	1
L:L:?1	R:R:S105	13.08	1	Yes	No	0	4	0	1
L:L:?1	R:R:T109	3.85	1	Yes	No	0	5	0	1
L:L:?1	R:R:E121	8.08	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F125	14.85	1	Yes	No	0	5	0	1
L:L:?1	R:R:L128	8.44	1	Yes	No	0	6	0	1
L:L:?1	R:R:S129	5.23	1	Yes	No	0	6	0	1
L:L:?1	R:R:W269	5.95	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L272	8.44	1	Yes	No	0	6	0	1
L:L:?1	R:R:L297	12.05	1	Yes	No	0	5	0	1
R:R:K34	R:R:Y29	8.36	0	No	Yes	6	7	2	1
R:R:Y110	R:R:Y29	3.97	0	No	Yes	5	7	2	1
R:R:W117	R:R:Y29	4.82	1	Yes	Yes	9	7	2	1
R:R:P196	R:R:Y29	15.3	0	No	Yes	3	7	2	1
R:R:N101	R:R:R120	7.23	0	No	Yes	5	6	1	2
R:R:M124	R:R:N101	11.22	0	Yes	No	6	5	2	1
R:R:T109	R:R:Y110	3.75	0	No	No	5	5	1	2
R:R:R120	R:R:T109	7.76	1	Yes	No	6	5	2	1
R:R:R120	R:R:W117	8	1	Yes	Yes	6	9	2	2
R:R:E121	R:R:W117	22.9	1	Yes	Yes	5	9	1	2
R:R:L195	R:R:W117	4.56	1	Yes	Yes	3	9	2	2
R:R:W117	R:R:Y198	4.82	1	Yes	Yes	9	4	2	2
R:R:E121	R:R:R120	5.82	1	Yes	Yes	5	6	1	2
R:R:E121	R:R:L195	3.98	1	Yes	Yes	5	3	1	2
R:R:L297	R:R:M124	4.24	0	No	Yes	5	6	1	2
R:R:F125	R:R:Y198	9.28	0	No	Yes	5	4	1	2
R:R:L128	R:R:W269	6.83	1	No	Yes	6	8	1	1
R:R:L174	R:R:S129	4.5	0	No	No	5	6	2	1
R:R:L195	R:R:Y198	9.38	1	Yes	Yes	3	4	2	2
R:R:F210	R:R:W269	12.03	0	No	Yes	7	8	2	1
R:R:F265	R:R:W269	8.02	1	Yes	Yes	9	8	2	1
R:R:F265	R:R:N303	6.04	1	Yes	Yes	9	9	2	2
R:R:L272	R:R:W269	5.69	1	No	Yes	6	8	1	1
R:R:N303	R:R:W269	6.78	1	Yes	Yes	9	8	2	1
R:R:A300	R:R:W269	2.59	0	No	Yes	7	8	2	1
R:R:G106	R:R:S105	1.86	0	No	No	4	4	2	1
R:R:F125	R:R:G122	1.51	0	No	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VIF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.72
Number of Linked Nodes	267
Number of Links	295
Number of Hubs	44
Number of Links mediated by Hubs	161
Number of Communities	4
Number of Nodes involved in Communities	41
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	48792
Length Of Smallest Path	3
Average Path Length	11.9175
Length of Longest Path	27
Minimum Path Strength	1.42
Average Path Strength	6.41045
Maximum Path Strength	20.81
Minimum Path Correlation	0.7
Average Path Correlation	0.925862
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	55.021
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	57.4974
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • sphingolipid binding • lipid binding • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • signaling receptor binding • G protein-coupled receptor binding • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • cell adhesion • regulation of cell adhesion • lamellipodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cellular component organization • cellular component biogenesis • cellular component assembly • lamellipodium organization • cellular component organization or biogenesis • cell projection assembly • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • negative regulation of biological process • regulation of actin filament bundle assembly • actin filament bundle organization • actin filament-based process • negative regulation of cellular process • stress fiber assembly • negative regulation of supramolecular fiber organization • regulation of actin filament organization • negative regulation of stress fiber assembly • actin cytoskeleton organization • actomyosin structure organization • negative regulation of cellular component organization • negative regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • negative regulation of actin filament bundle assembly • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • negative regulation of organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • heart trabecula morphogenesis • trabecula morphogenesis • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • cellular developmental process • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • epithelium development • endothelial cell differentiation • endothelium development • tissue development • epithelial cell differentiation • homeostatic process • regulation of bone remodeling • tissue homeostasis • regulation of tissue remodeling • regulation of bone resorption • bone resorption • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • regulation of multicellular organismal process • regulation of multicellular organismal development • regulation of developmental process • bone mineralization • regulation of biomineral tissue development • regulation of bone mineralization • ossification • biomineral tissue development • regulation of ossification • chemotaxis • taxis • response to external stimulus • locomotion • metabolic process • regulation of metabolic process • positive chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • regulation of response to stimulus • regulation of locomotion • system process • nervous system process • transmission of nerve impulse • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of cell motility • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • positive regulation of cellular process • regulation of smooth muscle cell proliferation • positive regulation of cell population proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • developmental growth • heart morphogenesis • organ growth • striated muscle tissue development • muscle structure development • cardiac muscle tissue growth involved in heart morphogenesis • animal organ morphogenesis • cardiac muscle tissue growth • muscle tissue development • muscle organ development • heart development • heart growth • cardiac muscle tissue development • growth • muscle tissue morphogenesis • developmental growth involved in morphogenesis • tissue morphogenesis • cardiac muscle tissue morphogenesis • growth involved in heart morphogenesis • muscle organ morphogenesis • cell chemotaxis • leukocyte chemotaxis • sphingolipid mediated signaling pathway • sphingosine-1-phosphate receptor signaling pathway • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • blood vessel maturation • developmental maturation • anatomical structure maturation • cell surface • external side of plasma membrane • membrane microdomain • membrane raft • presynapse • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • D2 dopamine receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • cell division • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • mitotic spindle organization • mitotic cell cycle process • microtubule-based process • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J89
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J89
Name	(2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol
Synonyms
Identifier
Formula	C19 H34 N O5 P
Molecular Weight	387.451
SMILES
PubChem	11452022
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	1
Total Bonds	60
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21453
Sequence	>7VIF_nogp_Chain_R D I I V R H Y N Y T G K L N T S V V F I L I C C F I I L E N I F V L L T I W K T K K F H R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S G A T T Y K L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K M K L H N G S N N F R L F L L I S A C W V I S L I L G G L P I M G W N C I S A L S S C S T V L P L Y H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T F E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C K V K T C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E M R R A F I R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YIC	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-	Gi1/β1/γ2	3.47	2024-12-11	To be published
	8YIC (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SAR247799	-		3.47	2024-12-11	To be published
	8G94	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69	Gi1/β1/γ2	3.15	2023-04-19	10.7554/eLife.88204
	8G94 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	-	CD69		3.15	2023-04-19	10.7554/eLife.88204
	7VIH	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.98	2022-09-28	10.1073/pnas.2117716119
	7VIH (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.98	2022-09-28	10.1073/pnas.2117716119
	7VIG	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-	Gi1/β1/γ2	2.89	2022-09-28	10.1073/pnas.2117716119
	7VIG (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	CBP-307	-		2.89	2022-09-28	10.1073/pnas.2117716119
	7VIF	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-	Gi1/β1/γ2	2.83	2022-09-28	10.1073/pnas.2117716119
	7VIF (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S-FTY720-P	-		2.83	2022-09-28	10.1073/pnas.2117716119
	7VIE	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	2.86	2022-09-28	10.1073/pnas.2117716119
	7VIE (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		2.86	2022-09-28	10.1073/pnas.2117716119
	7TD4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.6	2022-02-09	10.1038/s41467-022-28417-2
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	10.1038/s41467-022-28417-2
	7WF7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3.4	2022-01-05	10.1038/s41589-021-00930-3
	7WF7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3.4	2022-01-05	10.1038/s41589-021-00930-3
	7EO4	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-	Gi1/β1/γ2	2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO4 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	BAF312	-		2.86	2022-01-05	10.1038/s41589-021-00930-3
	7EO2	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-	Gi1/β1/γ2	2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EO2 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	FTY720-P	-		2.89	2022-01-05	10.1038/s41589-021-00930-3
	7EW7	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-	Gi1/β1/γ2	3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW7 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	SEW2871	-		3.27	2021-09-29	10.1038/s41422-021-00566-x
	7EW0	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-	Gi1/β1/γ2	3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EW0 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Ozanimod	-		3.42	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-	Gi1/β1/γ2	3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVZ (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Cenerimod	-		3.07	2021-09-29	10.1038/s41422-021-00566-x
	7EVY	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-	Gi1/β1/γ2	2.98	2021-09-29	10.1038/s41422-021-00566-x
	7EVY (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	Siponimod	-		2.98	2021-09-29	10.1038/s41422-021-00566-x
	3V2Y	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	2.8	2012-02-15	10.1126/science.1215904
	3V2W	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	PubChem 51892645	-	-	3.35	2012-02-15	10.1126/science.1215904

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