Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M40 3.4675416
2R:R:F71 4.842508
3R:R:L75 5.665409
4R:R:D79 6.3075409
5R:R:L80 3.215457
6R:R:W99 9.206547
7R:R:F101 6.986505
8R:R:E122 3.91405
9R:R:D130 6.0175438
10R:R:Y132 7.955408
11R:R:F133 4.4075405
12R:R:W158 5.2775409
13R:R:S165 4.095477
14R:R:Y174 5.088525
15R:R:H178 7.055422
16R:R:D192 4.915423
17R:R:F194 5.095421
18R:R:Y199 4.425426
19R:R:F208 7.148508
20R:R:Y219 4.8725409
21R:R:F282 3.7419
22R:R:W286 4.80429718
23R:R:L287 3.9075406
24R:R:F289 6.255616
25R:R:F290 6.898517
26R:R:N293 5.17515
27R:R:W313 3.422515
28R:R:Y316 6.486516
29R:R:I325 2.89508
30R:R:F332 4.24333639
31L:L:?1 6.641821110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:W313 R:R:Y316 19.90872.89YesYes156
2L:L:?1 R:R:Y316 51.20933.78YesYes106
3L:L:?1 R:R:V117 52.89467.21YesNo006
4R:R:M82 R:R:V117 42.79563.04NoNo076
5R:R:M82 R:R:S319 41.66344.6NoNo079
6R:R:D79 R:R:S319 41.12318.83YesNo099
7R:R:D79 R:R:N51 21.3566.73YesNo099
8R:R:L80 R:R:N51 11.99022.75YesNo079
9L:L:?1 R:R:V114 78.1234.81YesNo005
10R:R:S165 R:R:V114 77.28683.23YesNo075
11R:R:L115 R:R:S165 68.84096.01NoYes757
12R:R:L115 R:R:W158 86.76194.56NoYes059
13R:R:S74 R:R:W158 89.97816.18NoYes099
14R:R:I154 R:R:S74 1003.1NoNo089
15R:R:F71 R:R:I154 98.67495.02YesNo088
16R:R:D130 R:R:F71 87.59814.78YesYes088
17R:R:D130 R:R:T68 53.06832.89YesNo388
18R:R:N69 R:R:T68 49.44044.39NoNo398
19R:R:F332 R:R:N69 47.8582.42YesNo399
20R:R:F332 R:R:F336 22.073.22YesNo097
21R:R:F332 R:R:I58 18.17195.02YesNo097
22R:R:I58 R:R:T73 16.20353.04NoNo076
23R:R:C77 R:R:T73 14.22231.69NoNo066
24R:R:C77 R:R:I55 12.22821.64NoNo067
25R:R:A76 R:R:I55 10.22133.25NoNo097
26R:R:A57 R:R:F336 12.22824.16NoNo087
27R:R:S74 R:R:T123 23.38224.8NoNo098
28R:R:D79 R:R:S120 19.40692.94YesNo099
29R:R:L75 R:R:S120 18.73793YesNo099
30R:R:D79 R:R:N322 19.40696.73YesNo099
31R:R:L75 R:R:N322 18.73799.61YesNo099
32R:R:L124 R:R:L75 26.42484.15NoYes089
33R:R:V86 R:R:Y316 36.87773.79NoYes176
34R:R:V86 R:R:W109 66.0627.36NoNo075
35R:R:W109 R:R:W99 59.06992.81NoYes057
36R:R:F101 R:R:W99 44.609517.04YesYes057
37R:R:F101 R:R:T100 18.80879.08YesNo052
38R:R:T100 R:R:T98 15.07141.57NoNo025
39R:R:F101 R:R:W105 15.07143.01YesNo055
40R:R:F166 R:R:S111 25.00326.61NoNo046
41L:L:?1 R:R:F193 44.59029.83YesNo004
42R:R:F193 R:R:T195 43.11723.89NoNo043
43R:R:T195 R:R:Y174 30.90833.75NoYes235
44R:R:I169 R:R:Y174 17.16849.67NoYes055
45R:R:F289 R:R:W286 30.77964.01YesYes168
46L:L:?1 R:R:F289 26.44413.93YesYes106
47R:R:V117 R:R:W286 38.85244.9NoYes068
48L:L:?1 R:R:F290 63.04525.9YesYes107
49R:R:F290 R:R:W286 29.37094.01YesYes178
50L:L:?1 R:R:S207 12.31834.85YesNo005
51R:R:S207 R:R:T118 11.26986.4NoNo056
52R:R:I121 R:R:W286 23.07355.87NoYes178
53R:R:I121 R:R:P211 20.15953.39NoNo078
54R:R:F282 R:R:W286 50.57893.01YesYes198
55R:R:F208 R:R:F290 42.525416.08YesYes087
56R:R:F208 R:R:F282 19.47124.29YesYes089
57R:R:L124 R:R:Y326 23.53023.52NoNo089
58R:R:M279 R:R:Y219 40.90444.79NoYes089
59R:R:M215 R:R:M279 51.00355.78NoNo088
60R:R:F282 R:R:M215 56.03373.73YesNo098
61R:R:D130 R:R:L145 36.78769.5YesNo387
62R:R:L144 R:R:L145 35.19236.92NoNo047
63R:R:F133 R:R:L144 31.46158.53YesNo054
64R:R:F133 R:R:Y132 23.87115.16YesYes058
65R:R:R221 R:R:Y132 12.02884.12NoYes058
66R:R:T195 R:R:Y199 11.05756.24NoYes236
67R:R:P168 R:R:Y199 12.42124.17NoYes056
68R:R:L167 R:R:P168 10.38213.28NoNo055
69R:R:Y174 R:R:Y185 30.99193.97YesNo251
70R:R:A181 R:R:H178 11.26337.32NoYes242
71R:R:A181 R:R:Y185 29.94342.67NoNo241
72R:R:A181 R:R:F194 16.89825.55NoYes241
73R:R:D192 R:R:F194 11.53353.58YesYes231
74L:L:?1 R:R:N293 14.19664.43YesYes105
75R:R:H296 R:R:N293 11.07045.1NoYes135
76R:R:H296 R:R:V297 10.60728.3NoNo035
77R:R:F208 R:R:L287 27.01023.65YesYes086
78R:R:L275 R:R:Y219 10.29855.86NoYes089
79R:R:I278 R:R:Y219 20.55194.84NoYes089
80R:R:I278 R:R:T274 15.43163.04NoNo088
81R:R:K270 R:R:T274 10.29857.51NoNo078
82R:R:I325 R:R:Y326 17.78597.25YesNo089
83R:R:I291 R:R:L287 20.42974.28NoYes066
84R:R:I291 R:R:V295 18.21051.54NoNo064
85R:R:L75 R:R:T123 22.68115.9YesNo098
86L:L:?1 R:R:D113 34.25328.76YesNo107
87R:R:D113 R:R:V86 32.67725.84NoNo177
88R:R:F166 R:R:L115 18.66077.31NoNo745
89R:R:I169 R:R:S111 15.64396.19NoNo056
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V117 3.04 0 No No 7 6 2 1
R:R:D113 R:R:V86 5.84 1 No No 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 No Yes 7 6 2 1
R:R:D113 R:R:Y316 10.34 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 8.76 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 3.23 7 Yes No 7 5 2 1
L:L:?1 R:R:V114 4.81 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 7.21 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 6.4 0 No No 5 6 1 2
R:R:F193 R:R:T195 3.89 0 No No 4 3 1 2
L:L:?1 R:R:F193 9.83 1 Yes No 0 4 0 1
L:L:?1 R:R:S203 8.48 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 5.28 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 4.47 1 Yes No 5 5 1 2
L:L:?1 R:R:S207 4.85 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 16.08 0 Yes Yes 8 7 2 1
R:R:F289 R:R:W286 4.01 1 Yes Yes 6 8 1 2
R:R:F290 R:R:W286 4.01 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 3.22 1 Yes Yes 6 7 1 1
R:R:F289 R:R:N293 6.04 1 Yes Yes 6 5 1 1
R:R:F289 R:R:Y308 8.25 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 12.08 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 3.93 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 5.9 1 Yes Yes 0 7 0 1
R:R:H296 R:R:N293 5.1 1 No Yes 3 5 2 1
R:R:N293 R:R:Y308 5.81 1 Yes No 5 5 1 2
L:L:?1 R:R:N293 4.43 1 Yes Yes 0 5 0 1
R:R:H296 R:R:Y308 10.89 1 No No 3 5 2 2
R:R:N312 R:R:Y316 11.63 1 No Yes 5 6 1 1
L:L:?1 R:R:N312 11.08 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 2.89 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 3.78 1 Yes Yes 0 6 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
100.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
100.00Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
100.00Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8GGJEpinephrine8GGJ-β2-Epinephrine
100.00Single8GGNEpinephrine8GGN-β2-Epinephrine
100.00Single8GGUEpinephrine8GGU-β2-Epinephrine
100.00Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
100.00Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
100.00Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
91.67Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
91.67Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
91.67Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
91.67Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
91.67Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
91.67Single7XKAEpinephrine7XKA-β2-Epinephrine
91.67Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
91.67Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
91.67Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
91.67Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
91.67Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
91.67Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
90.91Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
90.91Single6PS4ICI 118-5516PS4-β2-ICI 118-551
90.91Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
90.91Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
90.91Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
90.91Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
90.91Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GGIEpinephrine8GGI-β2-Epinephrine
90.91Single8GGKEpinephrine8GGK-β2-Epinephrine
90.91Single8GGMEpinephrine8GGM-β2-Epinephrine
90.91Single8GGPEpinephrine8GGP-β2-Epinephrine
90.91Single8GGQEpinephrine8GGQ-β2-Epinephrine
90.91Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
84.62Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
84.62Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
84.62Single6H7JIsoprenaline6H7J-β1-Isoprenaline
84.62Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
84.62Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
84.62Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
84.62Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
84.62Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
84.62Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
84.62Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
84.62Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
84.62Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
83.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
83.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
83.33Single3NY8ICI 118-5513NY8-β2-ICI 118-551
83.33Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
83.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
83.33Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
83.33Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
83.33Single6H7MSalbutamol6H7M-β1-Salbutamol
83.33Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
83.33Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
83.33Single6PS1Timolol6PS1-β2-Timolol
83.33Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
83.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
83.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
83.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
83.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
83.33Single8JJOAlprenolol8JJO-β2-Alprenolol
83.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
83.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
83.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
83.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
83.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
83.33Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
81.82Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
81.82Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
81.82Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
81.82Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
81.82Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GGVEpinephrine8GGV-β2-Epinephrine
81.82Single8GGWEpinephrine8GGW-β2-Epinephrine
81.82Single8GGXEpinephrine8GGX-β2-Epinephrine
81.82Single8GH0Epinephrine8GH0-β2-Epinephrine
81.82Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
78.57Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
78.57Single4AMIBucindolol4AMI-β1-Bucindolol
78.57Single4LDEBI1671074LDE-β2-BI167107
78.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
78.57Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
78.57Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
78.57Single8JJ8Formoterol8JJ8-β2-Formoterol
78.57Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
76.92Single2Y03Isoprenaline2Y03-β1-Isoprenaline
76.92Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
76.92Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
76.92Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
76.92Single6E67BI1671076E67-β2-BI167107-Gs (fused)
76.92Single7WC6LSD7WC6-5-HT2A-LSD
76.92Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
76.92Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
76.92Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
76.92Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
76.92Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
76.92Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
76.92Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
75.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
75.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
75.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GGLEpinephrine8GGL-β2-Epinephrine
75.00Single8GGTEpinephrine8GGT-β2-Epinephrine
75.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
75.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
75.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
75.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
75.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
75.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
73.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
73.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
73.33Single6H7LDobutamine6H7L-β1-Dobutamine
73.33Single6IBLArformoterol6IBL-β1-Arformoterol
73.33Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
72.73Single3PBLEticlopride3PBL-D3-Eticlopride
72.73Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
72.73Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
72.73Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
72.73Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GGSEpinephrine8GGS-β2-Epinephrine
72.73Single8GGYEpinephrine8GGY-β2-Epinephrine
72.73Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
72.73Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
71.43Single2YDVNECA2YDV-A2A-NECA
71.43Single3P0GBI1671073P0G-β2-BI167107
71.43Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
71.43Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
71.43Single4UHRCGS216804UHR-A2A-CGS21680
71.43Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
71.43Single5G53NECA5G53-A2A-NECA-Gs
71.43Single6WGTLSD6WGT-5-HT2A-LSD
71.43Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
71.43Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
71.43Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
71.43Consensus5ht5_offOrthosteric Ligand5ht5a_off
71.43Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
71.43Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
71.43Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
71.43Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
71.43Consensushistamine_offOrthosteric Ligandh1_off
69.23Single2Y02Carmoterol2Y02-β1-Carmoterol
69.23Single2Y04Salbutamol2Y04-β1-Salbutamol
69.23Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
69.23Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
69.23Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
69.23Single7BU7BI1671077BU7-β1-BI167107
69.23Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
69.23Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
69.23Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
69.23Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
69.23Single7WC7Lisuride7WC7-5-HT2A-Lisuride
69.23Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
69.23Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
69.23Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
69.23Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
69.23Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
69.23Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
69.23Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
69.23Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
69.23Single8X64Desloratadine8X64-H1-Desloratadine
69.23Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
69.23Consensustar_onOrthosteric Ligandta1_on
68.75Single3NY9PubChem 9131033NY9-β2-PubChem 913103
66.67Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
66.67Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
66.67Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
66.67Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
66.67Single6KUXRS-799486KUX-α2a-RS-79948
66.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
66.67Single6MXTSalmeterol6MXT-β2-Salmeterol
66.67Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
66.67Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
66.67Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
66.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
66.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
66.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
66.67Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
66.67Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
66.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
66.67Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
66.67Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
66.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
66.67Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
66.67Consensusalpha1_onOrthosteric Ligandalpha1a_on
66.67Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
66.67Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
66.67Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
66.67Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
66.67Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
66.67Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
64.71Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
64.71Single4IARErgotamine4IAR-5-HT1B-Ergotamine
64.71Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
64.29Single5C1MBU725C1M-μ-BU72
64.29Single5TVNLSD5TVN-5-HT2B-LSD
64.29Single5WIUNemonapride5WIU-D4-Nemonapride
64.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
64.29Single6PS6Timolol6PS6-β2-Timolol
64.29Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
64.29Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
64.29Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
64.29Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
64.29Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
64.29Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
64.29Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
64.29Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
63.64Single8GGREpinephrine8GGR-β2-Epinephrine
63.64Single8GGZEpinephrine8GGZ-β2-Epinephrine
63.64Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
62.50Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
62.50Single7UM4AS26747237UM4-5-HT5A-AS2674723
62.50Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
62.50Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
62.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
62.50Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
61.54Single6A94Zotepine6A94-5-HT2A-Zotepine
61.54Single6TPGEMPA6TPG-OX2-EMPA
61.54Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
61.54Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
61.54Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
61.54Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
61.54Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
61.54Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
61.54Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
61.54Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
61.54Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
61.54Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
61.54Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Consensus5ht5_onOrthosteric Ligand5ht5a_on
61.54Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
61.54Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
60.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
60.00Single4U15Tiotropium4U15-M3-Tiotropium
60.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
60.00Single6J21Aprepitant6J21-NK1-Aprepitant
60.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
60.00Single6OL9Tiotropium6OL9-M5-Tiotropium
60.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
60.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
60.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
60.00Single8E0GBU728E0G-μ-BU72
60.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
60.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
60.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
60.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
60.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
58.82Single4UG2CGS216804UG2-A2A-CGS21680
58.82Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
58.82Single8X5YAstemizole8X5Y-H1-Astemizole
58.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
58.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
58.33Single7SRQLSD7SRQ-5-HT2B-LSD
58.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
58.33Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
58.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
58.33Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GH1Epinephrine8GH1-β2-Epinephrine
58.33Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
58.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
58.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
58.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
57.14Single2Y01Dobutamine2Y01-β1-Dobutamine
57.14Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
57.14Single4EJ4Naltrindole4EJ4-δ-Naltrindole
57.14Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
57.14Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
57.14Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
57.14Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
57.14Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
57.14Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
57.14Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
57.14Single7UL4Alvimopan7UL4-μ-Alvimopan
57.14Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
57.14Single8X63Mepyramine8X63-H1-Mepyramine
57.14Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
57.14Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
57.14Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
57.14Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
57.14Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
57.14Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
57.14Consensushistamine_onOrthosteric Ligandh1_on h4_on
56.25Single5CXVTiotropium5CXV-M1-Tiotropium
56.25Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
56.25Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
56.25Single7YITNalfurafine7YIT-κ-Nalfurafine
56.25Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single8JJLOlodaterol8JJL-β2-Olodaterol
56.25Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
56.25Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
56.25Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
56.25Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
56.25Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
55.56Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
54.55Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single6AKXA4R6AKX-CCR5-A4R
53.85Single6TODEMPA6TOD-OX1-EMPA-Na
53.85Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
53.85Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
53.85Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
53.85Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
53.85Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
53.85Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8IWESpermidine8IWE-TAAR9-Spermidine
53.85Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Single2Y00Dobutamine2Y00-β1-Dobutamine
53.33Single5WQCEMPA5WQC-OX2-EMPA
53.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
53.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
53.33Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
53.33Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
53.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
53.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
53.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
53.33Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
53.33Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
53.33Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
53.33Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
52.94Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
52.94Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
52.94Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
52.94Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
52.94Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
52.94Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
52.94Consensusendothelin_offOrthosteric Ligandetb_off
52.94Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
52.94Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
52.63Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
52.63Single6HLOAprepitant6HLO-NK1-Aprepitant
50.00Single2YDOAdenosine2YDO-A2A-Adenosine
50.00Single3RZECidoxepin3RZE-H1-Cidoxepin
50.00Single3UZAGTPL92363UZA-A2A-GTPL9236
50.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
50.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
50.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
50.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
50.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
50.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
50.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
50.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
50.00Single5X93K-87945X93-ETB-K-8794
50.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
50.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
50.00Single6J20Aprepitant6J20-NK1-Aprepitant
50.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
50.00Single6PT3DPI-2876PT3-δ-DPI-287
50.00Single6TPNHTL66416TPN-OX2-HTL6641
50.00Single6VI4JDTic6VI4-κ-JDTic
50.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
50.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
50.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
50.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
50.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
50.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
50.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
50.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
50.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
50.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
50.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
50.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
50.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
50.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
50.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
50.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
50.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
50.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
50.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
50.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
50.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
47.62Single7C61Ergotamine7C61-5-HT1B-Ergotamine
47.37Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.06Single6CM4Risperidone6CM4-D2-Risperidone
47.06Single6HLPNetupitant6HLP-NK1-Netupitant
47.06Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
47.06Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
47.06Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single4DAJTiotropium4DAJ-M3-Tiotropium
46.67Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
46.67Single4MQSIperoxo4MQS-M2-Iperoxo
46.67Single4U14Tiotropium4U14-M3-Tiotropium
46.67Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
46.67Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
46.67Single5DSGTiotropium5DSG-M4-Tiotropium
46.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
46.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
46.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
46.67Single6TOTLemborexant6TOT-OX1-Lemborexant
46.67Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
46.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
46.67Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
46.67Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
46.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
46.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
46.67Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
46.67Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
46.67Consensusadenosine_onOrthosteric Liganda1_on a2_on
46.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
46.67Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
46.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
46.67Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
46.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
46.67Consensusnucleotide_onOrthosteric Ligandadenosine_on
46.67Consensustachykinin_offOrthosteric Ligandnk1_off
46.15Single6HLLCP999946HLL-NK1-CP99994
46.15Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
46.15Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
46.15Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
45.45Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
45.45Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
45.00Single3QAKUK-4320973QAK-A2A-UK-432097
45.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
44.44Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
44.44Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
44.44Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
44.44Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
44.44Single7EZCUKA7EZC-A2A-UKA
44.44Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
44.44Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
44.44Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
43.75Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
43.75Single5XPRBosentan5XPR-ETB-Bosentan
43.75Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
43.75Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
43.75Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
43.75Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
43.75Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
43.75Single6TP6Filorexant6TP6-OX1-Filorexant
43.75Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
43.75Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
43.75Single8EA0Iperoxo8EA0-M3-Iperoxo
43.75Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
43.75Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
43.75Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
43.75Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.75Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
42.86Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
42.86Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
42.86Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
42.86Single5DHHSB-6121115DHH-NOP-SB-612111
42.86Single5WF5UK-4320975WF5-A2A-UK-432097
42.86Single5WS3EMPA5WS3-OX2-EMPA
42.86Single6AKYMaraviroc6AKY-CCR5-Maraviroc
42.86Single6B73PubChem 1319551386B73-κ-PubChem 131955138
42.86Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
42.86Single6ME2Ramelteon6ME2-MT1-Ramelteon
42.86Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single6PT2KGCHM076PT2-δ-KGCHM07
42.86Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
42.86Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
42.86Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
42.86Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
42.86Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
42.86Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
42.86Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
42.86Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
42.86Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
42.86Consensusorexin_offOrthosteric Ligandox2_off ox1_off
42.11Single5WF6UK-4320975WF6-A2A-UK-432097
42.11Single7SK9CCX6627SK9-ACKR3-CCX662
42.11Single7XN9L-054,5227XN9-SST2-L-054,522
42.11Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
41.67Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
41.67Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
41.67Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
41.67Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
41.67Consensussensory_onOrthosteric Ligandopsin_on
41.18Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
41.18Single4DJHJDTic4DJH-κ-JDTic
41.18Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
41.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
41.18Single6E59L-7607356E59-NK1-L-760735
41.18Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
41.18Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
41.18Single7B6WCyclazosin7B6W-α1b-Cyclazosin
41.18Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
41.18Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
41.18Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.18Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
41.18Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
41.18Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
41.18Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
41.18Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
41.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
41.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
41.18Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
41.18Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
41.18Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
41.18Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
41.18Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
40.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
40.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
40.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
40.00Single6IQLL7458706IQL-D4-L745870
40.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
40.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
40.00Single6V9SGTPL114036V9S-OX1-GTPL11403
40.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
40.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
40.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
40.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
40.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
40.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
40.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
40.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
40.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
40.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.89Single6A93Risperidone6A93-5-HT2A-Risperidone
38.89Single6ZG4HTL00099366ZG4-M1-HTL0009936
38.89Single7DFPSpiperone7DFP-D2-Spiperone
38.89Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
38.89Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.89Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
38.89Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
38.89Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
38.89Single8JWZAB9288JWZ-A2A-AB928-Na
38.89Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
38.89Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
38.89Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.89Consensusgs_steroidOrthosteric Ligandgs_bileacid
38.89Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.89Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.46Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.46Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
38.46Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
38.46Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
37.50Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
37.50Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
37.50Single6DRXLisuride6DRX-5-HT2B-Lisuride
37.50Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
37.50Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
37.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
37.50Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
37.50Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
37.50Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
37.50Single8CU6LJ-45178CU6-A2A-LJ-4517
37.50Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
37.50Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
37.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
37.50Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
37.50Consensusgi_hcarOrthosteric Ligandgi_hca
37.50Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
37.50Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
36.84Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
36.84Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
36.84Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
36.84Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
36.84Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
36.84Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
36.84Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
36.84Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
36.84Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
36.84Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
36.84Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Consensusorexin_onOrthosteric Ligandox2_on
36.84Consensussteroid_onOrthosteric Ligandbileacid_on
36.36Single5MZPCaffeine5MZP-A2A-Caffeine-Na
36.36Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
36.36Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
35.71Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
35.71Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
35.71Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
35.71Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
35.71Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
35.71Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
35.71Single6TP4ACT-4622066TP4-OX1-ACT-462206
35.71Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
35.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.71Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
35.71Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
35.71Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
35.71Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
35.71Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
35.71Single8K5BNiacin8K5B-HCA2-Niacin
35.71Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.29Single5NM2ZM2413855NM2-A2A-ZM241385-Na
35.29Single6LUQHaloperidol6LUQ-D2-Haloperidol
35.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
35.29Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7SINNPS-21437SIN-CaS-NPS-2143
35.29Single7SINNPS-21437SIN-CaS-NPS-2143
35.29Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
35.29Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
35.29Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
35.29Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
35.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.29Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
35.29Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
35.00Single5ZTYAM102575ZTY-CB2-AM10257
35.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
35.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
35.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
35.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
35.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
35.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
34.78Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
34.78Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
34.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
34.78Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
34.78Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
34.62Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
33.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
33.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
33.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
33.33Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
33.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
33.33Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
33.33Single5K2DZM2413855K2D-A2A-ZM241385
33.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
33.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
33.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
33.33Single6JZHZM2413856JZH-A2A-ZM241385-Na
33.33Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Single6PS7ZM2413856PS7-A2A-ZM241385-Na
33.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
33.33Single7EPENAM5637EPE-mGlu-NAM563
33.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
33.33Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
33.33Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Single7F8ULintitript7F8U-CCKA-Lintitript
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
33.33Single7TUYGSK682753A7TUY-GPR183-GSK682753A
33.33Single7W41PD1762527W41-BB2-PD176252
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
33.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
33.33Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
33.33Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8PWNTheophylline8PWN-A2A-Theophylline
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
33.33Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
33.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
33.33Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusbombesin_offOrthosteric Ligandbb2_off
33.33Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
33.33Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
33.33Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
33.33Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
33.33Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
33.33Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
33.33Consensusgt_class-aOrthosteric Ligandgt_opsin
33.33Consensusgt_opsinOrthosteric Ligandgt_sensory
33.33Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
33.33Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
33.33Consensussst_onOrthosteric Ligandsst2_on sst4_on
32.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
32.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
31.82Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
31.82Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
31.82Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.82Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
31.82Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
31.82Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.82Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
31.58Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.58Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
31.58Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
31.58Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
31.58Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
31.58Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
31.58Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
31.58Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
31.58Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
31.58Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
31.58Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
31.58Single8WU1KCA8WU1-CB1-KCA-Arrestin1
31.58Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
31.58Consensusgi_class-fOther Ligandgi_frizzled
31.58Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
31.58Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
31.58Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
31.58Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.58Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
31.25Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
31.25Single3REYPubChem 56973REY-A2A-PubChem 5697
31.25Single5IU4ZM2413855IU4-A2A-ZM241385-Na
31.25Single5IU7Q274563465IU7-A2A-Q27456346-Na
31.25Single5IUBQ274563445IUB-A2A-Q27456344-Na
31.25Single5JTBZM2413855JTB-A2A-ZM241385
31.25Single5K2BZM2413855K2B-A2A-ZM241385-Na
31.25Single5K2CZM2413855K2C-A2A-ZM241385-Na
31.25Single5NLXZM2413855NLX-A2A-ZM241385-Na
31.25Single5NM4ZM2413855NM4-A2A-ZM241385-Na
31.25Single6AQFZM2413856AQF-A2A-ZM241385
31.25Single6TP3Nemorexant6TP3-OX1-Nemorexant
31.25Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
31.25Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
31.25Single7AROLUF58337ARO-A2A-LUF5833-Na
31.25Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
31.25Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.25Single7T32ZM2413857T32-A2A-ZM241385
31.25Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
31.25Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
31.25Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
31.25Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
31.25Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
31.25Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
31.25Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
31.25Single8K5CAcipimox8K5C-HCA2-Acipimox
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
31.25Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.25Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
31.25Consensushca_onOrthosteric Ligandhca2_on hca3_on
31.25Consensushcar_onOrthosteric Ligandhca_on
31.25Consensussensory_offOrthosteric Ligandopsin_off
30.77Single3RFMCaffeine3RFM-A2A-Caffeine
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
30.77Single8A2OTheophylline8A2O-A2A-Theophylline-Na
30.43Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
30.43Consensusangiotensin_onOrthosteric Ligandat1_on
30.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
30.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
30.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
30.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
30.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.63Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
29.63Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
29.41Single3EMLZM2413853EML-A2A-ZM241385
29.41Single4EIYZM2413854EIY-A2A-ZM241385-Na
29.41Single4YAYZD-71554YAY-AT1-ZD-7155
29.41Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
29.41Single5IU8Q274563475IU8-A2A-Q27456347-Na
29.41Single5K2AZM2413855K2A-A2A-ZM241385-Na
29.41Single5OLGZM2413855OLG-A2A-ZM241385-Na
29.41Single5UENDU1725UEN-A1-DU172
29.41Single5VRAZM2413855VRA-A2A-ZM241385-Na
29.41Single6LPJZM2413856LPJ-A2A-ZM241385-Na
29.41Single6LPKZM2413856LPK-A2A-ZM241385-Na
29.41Single6S0LZM2413856S0L-A2A-ZM241385
29.41Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
29.41Single7PYRPSB-21157PYR-A2A-PSB-2115
29.41Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
29.41Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
29.41Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.41Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
29.41Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
29.41Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
29.41Single8K5DGSK2560738K5D-HCA2-GSK256073
29.41Consensusa2_offOrthosteric Liganda2a_off
29.41Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
29.41Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Consensusblt_onOrthosteric Ligandblt1_on
29.41Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Consensusleuko_onOrthosteric Ligandblt_on
29.41Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
29.17Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.17Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
29.17Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
28.57Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
28.57Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
28.57Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
28.57Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
28.57Single6ME5Agomelatine6ME5-MT1-Agomelatine
28.57Single6ME9Ramelteon6ME9-MT2-Ramelteon
28.57Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
28.57Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
28.57Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
28.57Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
28.57Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
28.57Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
28.57Single7WC5Psilocin7WC5-5-HT2A-Psilocin
28.57Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
28.57Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
28.57Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
28.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
28.57Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
28.57Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
28.57Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Consensuslpl_offOrthosteric Ligands1p_off lpa_off
28.57Consensuslpl_onOrthosteric Ligands1p_on lpa_on
28.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
28.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
27.78Single5CGCHTL142425CGC-mGlu5-HTL14242
27.78Single5IUAQ274563485IUA-A2A-Q27456348-Na
27.78Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
27.78Single5N2SPSB365N2S-A1-PSB36
27.78Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
27.78Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.78Single6LPLZM2413856LPL-A2A-ZM241385-Na
27.78Single6S0QZM2413856S0Q-A2A-ZM241385
27.78Single6WQAZM2413856WQA-A2A-ZM241385-Na
27.78Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
27.78Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
27.78Single7RM5ZM2413857RM5-A2A-ZM241385-Na
27.78Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.78Single8FYNZM2413858FYN-A2A-ZM241385-Na
27.78Single8GNEKW-63568GNE-A2A-KW-6356-Na
27.78Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
27.78Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
27.78Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
27.78Single8QOTNanobody E8QOT-μ-Nanobody E
27.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
27.78Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
27.27Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
27.27Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
27.27Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
27.27Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
27.27Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
27.27Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.92Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
26.92Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
26.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
26.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
26.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
26.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
26.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
26.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
26.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
26.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.32Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.32Single5XR8AM8415XR8-CB1-AM841
26.32Single5XRAAM115425XRA-CB1-AM11542
26.32Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
26.32Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.32Single7PX4PSB-21137PX4-A2A-PSB-2113
26.32Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
26.32Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.32Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
26.32Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.32Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
26.32Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
26.32Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
26.32Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.32Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.32Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.32Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.32Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Consensuslpa_offOrthosteric Ligandlpa1_off
26.32Consensuslpa_onOrthosteric Ligandlpa1_on
26.32Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
26.32Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
26.09Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
26.09Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.09Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
26.09Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
25.93Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.81Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.81Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
25.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
25.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
25.00Single3PWHZM2413853PWH-A2A-ZM241385
25.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
25.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single4N4WSANT-14N4W-SMO-SANT-1
25.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single6IGLIRL16206IGL-ETB-IRL1620
25.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
25.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
25.00Single7K15MKD0467K15-BLT1-MKD046-Na
25.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
25.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
25.00Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
25.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
25.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
25.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
25.00Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
25.00Single8IHKAcifran8IHK-HCA3-Acifran
25.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
25.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
25.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
25.00Consensusblt_offOrthosteric Ligandblt1_off
25.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
25.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
25.00Consensusdp_offOrthosteric Liganddp2_off
25.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
25.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
25.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
24.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
24.14Single6IGKEndothelin-36IGK-ETB-Endothelin-3
24.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
24.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
24.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
24.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
23.81Single5CGDHTL142425CGD-mGlu5-HTL14242
23.81Single6K1QIRL25006K1Q-ETB-IRL2500
23.81Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
23.81Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
23.81Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
23.81Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
23.81Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
23.81Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
23.81Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.81Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.53Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
23.53Single5UVIZM2413855UVI-A2A-ZM241385
23.53Single6MH8ZM2413856MH8-A2A-ZM241385
23.53Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
23.53Single6TPKRetosiban6TPK-OT-Retosiban
23.53Single6ZG9GSK10347026ZG9-M1-GSK1034702
23.53Single7VODCariprazine7VOD-5-HT2A-Cariprazine
23.53Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.53Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.53Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
23.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
23.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
23.53Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
23.53Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
23.53Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
23.53Consensuss1p_offOrthosteric Ligands1p1_off
23.53Consensusvasopressin-ot_offOrthosteric Ligandot_off
23.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
23.08Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.08Single7WC4Serotonin7WC4-5-HT2A-Serotonin
23.08Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.08Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
23.08Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
23.08Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single5EE7MK08935EE7-Glucagon-MK0893
22.73Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
22.73Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
22.73Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
22.73Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.73Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
22.73Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.73Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
22.73Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.22Single5TGZAM65385TGZ-CB1-AM6538
22.22Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.22Single6D27CAY104716D27-DP2-CAY10471
22.22Single6GPSMK08126GPS-CCR2-MK0812
22.22Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
22.22Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
22.22Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
22.22Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
22.22Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
22.22Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
22.22Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
22.22Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
22.22Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
22.22Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.22Consensuscck_offOrthosteric Ligandccka_off
22.22Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
22.22Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
22.22Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.22Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
22.22Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
22.22Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
22.22Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
22.22Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.22Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
21.88Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.74Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
21.74Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
21.74Consensusclass-d_offOrthosteric Ligandste2_off
21.74Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
21.74Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
21.74Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
21.43Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
21.43Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.43Single6TQ9SB-4081246TQ9-OX1-SB-408124
21.43Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.43Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
21.43Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.43Consensusgo_class-b1Orthosteric Ligandgo_crf
21.43Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
21.05Single6GPXMK08126GPX-CCR2-MK0812
21.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
21.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
21.05Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
21.05Single7C4SS1P7C4S-S1P3-S1P
21.05Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
21.05Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
21.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
21.05Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.83Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
20.83Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
20.83Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.83Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
20.83Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
20.69Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.69Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
20.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
20.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
20.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
20.00Single7P2L4YI7P2L-mGlu5-4YI
20.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
20.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
20.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
20.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
20.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
20.00Consensuschemerin_onOrthosteric Ligandcml1_on
20.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
19.35Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
19.35Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.35Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
19.23Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.23Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
19.23Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.23Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
19.23Consensusclass-d_onOrthosteric Ligandste2_on
19.23Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
19.23Consensusgi_class-dOrthosteric Ligandgi_ste
19.23Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.05Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
19.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.05Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
19.05Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
19.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
19.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
19.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
19.05Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
19.05Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
19.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
19.05Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
19.05Consensusclass-b2_onOrthosteric Ligandadgrg_on
19.05Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
19.05Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
19.05Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.75Single3OE9IT1t3OE9-CXCR4-IT1t
18.75Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
18.75Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
18.75Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.75Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
18.75Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
18.75Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
18.52Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.52Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
18.52Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.52Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
18.52Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
18.52Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
18.52Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
18.52Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
18.18Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.18Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
18.18Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
18.18Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
17.86Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
17.86Consensusclass-d_onOrthosteric Ligandste2_on
17.65Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
17.65Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.65Consensuspth_onOrthosteric Ligandpth1_on pth2_on
17.39Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
17.39Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
17.39Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
17.39Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusclass-d_offOrthosteric Ligandste2_off
17.39Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
17.39Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.24Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.24Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.24Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.24Consensusgi_class-dOrthosteric Ligandgi_ste
17.24Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
17.24Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.24Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Single4XT1Fractalkine4XT1-US28-Fractalkine
16.67Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
16.67Single6FFIMMPEP6FFI-mGlu5-MMPEP
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.67Single6LMLGlucagon6LML-Glucagon-Glucagon
16.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
16.67Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.67Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
16.67Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
16.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
16.67Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
16.67Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
16.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
16.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.67Consensusgnrh_offOrthosteric Ligandgnrh1_off
16.67Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
16.13Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.13Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.13Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
16.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
15.79Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.79Single6FFHFenobam6FFH-mGlu5-Fenobam
15.79Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.79Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.79Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.79Single6IIVDaltroban6IIV-TP-Daltroban
15.79Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.79Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.79Consensushcar_offOrthosteric Ligandsuccinate_off
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.79Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
15.79Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.79Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
15.62Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
15.62Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
15.62Consensusglp_onOrthosteric Ligandglp1_on glp2_on
15.38Single3OE0CVX153OE0-CXCR4-CVX15
15.38Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
15.38Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.38Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
15.38Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
15.38Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.38Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.15Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.15Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.15Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
15.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
15.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
15.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.00Consensusep_offOrthosteric Ligandep4_off
14.81Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.81Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.81Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.81Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
14.81Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
14.81Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
14.81Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.81Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.71Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
14.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
14.71Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.71Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.29Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.29Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
14.29Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
14.29Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
14.29Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
14.29Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.29Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.29Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
14.29Consensusclass-c_onOther Ligandgabab_on mglu_on
14.29Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
14.29Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
14.29Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.79Single4XT3Fractalkine4XT3-US28-Fractalkine
13.79Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
13.79Single6FJ3PTH6FJ3-PTH1-PTH
13.79Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.79Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.79Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.79Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
13.79Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.64Single5X33BIIL2605X33-BLT1-BIIL260
13.64Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.64Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
13.64Single6IIURamatroban6IIU-TP-Ramatroban
13.64Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
13.64Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.64Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.64Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.64Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
13.64Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.64Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
13.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.33Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
13.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.16Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.04Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.04Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
13.04Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
13.04Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
13.04Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.04Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.90Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.90Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.90Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.90Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.82Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.50Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single3OE8IT1t3OE8-CXCR4-IT1t
12.50Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.50Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
12.50Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
12.50Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
12.50Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
12.50Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgs_class-b2Orthosteric Ligandgs_adgr
12.50Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
12.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
12.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
12.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
11.76Single5L7IVismodegib5L7I-SMO-Vismodegib
11.76Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.76Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.76Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.76Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusclass-t_onOrthosteric Ligandtaste2_on
11.76Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.76Consensusgs_class-tOrthosteric Ligandgs_taste
11.76Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.76Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.54Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.54Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
11.54Single7SK5CXCL127SK5-ACKR3-CXCL12
11.54Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensussst_offOrthosteric Ligandsst2_off
11.43Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.11Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.11Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.11Single7XNACYN1548067XNA-SST2-CYN154806
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.11Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.11Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.11Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
11.11Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.11Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
10.71Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.71Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.71Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.71Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.53Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.53Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.53Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.53Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.53Single8K2WAMG4878K2W-CXCR3-AMG487
10.53Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.53Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.53Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.34Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.26Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
10.00Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.00Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.00Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.68Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.68Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
9.68Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.52Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
9.52Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.52Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.52Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.38Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.38Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.38Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.09Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.09Single5V56TC1145V56-SMO-TC114
9.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.09Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.09Single7F1TMIP-1a7F1T-CCR5-MIP-1a
9.09Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.09Consensusclass-c_offOther Ligandgabab_off mglu_off
9.09Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.09Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.09Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.82Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
8.82Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.70Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.70Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.70Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.70Single4XESNeurotensin4XES-NTS1-Neurotensin
8.70Single6OS2TRV0266OS2-AT1-TRV026
8.70Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.70Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
8.70Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.70Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.70Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
8.70Consensusnts_offOrthosteric Ligandnts1_off
8.57Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.33Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.33Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.33Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.69Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
7.41Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
7.41Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.41Single7SHEPI; PE7SHE-GPR158-PI; PE
7.41Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
6.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.67Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
6.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.45Single7SK3CXCL127SK3-ACKR3-CXCL12
6.25Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.25Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.25Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
6.25Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.25Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.06Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.06Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.88Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.88Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.88Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.88Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.88Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.56Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.56Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.56Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.56Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.56Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.56Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.26Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.26Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.26Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.26Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.26Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.26Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.13Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.00Single6ZINSR486926ZIN-NTS1-SR48692
5.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.00Single7VV6C48/807VV6-MRGPRX2-C48/80
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8IYXYL-3658IYX-GPR34-YL-365
5.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
4.76Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.76Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.76Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.76Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.76Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.76Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.76Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.55Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.55Single6Z4SSR486926Z4S-NTS1-SR48692
4.55Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.55Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.35Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.35Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.35Single5V57TC1145V57-SMO-TC114
4.35Single6OS1TRV0266OS1-AT1-TRV026
4.35Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.35Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.35Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.35Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.17Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.17Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.17Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.17Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.17Consensuschemokine_offOrthosteric Ligandcxcr_off
4.17Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.17Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.17Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.17Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.17Consensusnts_onOrthosteric Ligandnts1_on
4.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single6KNMJN241-96KNM-Apelin-JN241-9
3.70Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.94Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.78Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.33Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.33Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 8GGO
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo sapiens
Ligand Epinephrine
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.2
Date 2024-03-06
D.O.I. 10.1038/s41586-024-07153-1
Net Summary
Imin 2.89
Number of Linked Nodes 252
Number of Links 280
Number of Hubs 31
Number of Links mediated by Hubs 128
Number of Communities 8
Number of Nodes involved in Communities 53
Number of Links involved in Communities 71
Path Summary
Number Of Nodes in MetaPath 90
Number Of Links MetaPath 89
Number of Shortest Paths 45020
Length Of Smallest Path 3
Average Path Length 13.1043
Length of Longest Path 30
Minimum Path Strength 1.345
Average Path Strength 5.29179
Maximum Path Strength 20.91
Minimum Path Correlation 0.71
Average Path Correlation 0.940277
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 57.2708
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.7009
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeG1I
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier(5~{R},6~{R})-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
FormulaC11 H15 N O3
Molecular Weight209.242
SMILESCN[C@@H]1CCc2c(ccc(c2O)O)[C@H]1O
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>8GGO_Chain_R
VVGMGIVMS LIVLAIVFG NVLVITAIA KFERLQTVT NYFITSLAC 
ADLVMGLAV VPFGAAHIL TKTWTFGNF WCEFWTSID VLCVTASIE 
TLCVIAVDR YFAITSPFK YQSLLTKNK ARVIILMVW IVSGLTSFL 
PIQMHWYRA THQEAINCY AEETCCDFF TNQAYAIAS SIVSFYVPL 
VIMVFVYSR VFQEAKRQL QKIDKSEGR HKALKTLGI IMGTFTLCW 
LPFFIVNIV HVIQDNLIR KEVYILLNW IGYVNSGFN PLIYCRSPD 
FRIAFQELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.42007-10-3010.1126/science.1150577
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-1610.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI 118-551--2.842010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-1110.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--3.162010-08-1110.1021/ja105108q
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.22011-07-2010.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-2310.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.482016-01-1310.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D6LAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-07-1310.1038/nature18636
5X7DAAmineAdrenergicβ2Homo sapiens(S)-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-2610.1126/science.aaw8981
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.82019-11-2010.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiens(S)-AlprenololGTPL11074-3.12020-03-2510.1038/s41589-020-0549-2
6PRZAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiens(S)-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI 118-551--2.62019-11-1310.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiens(S)-Propranolol--2.92019-11-1310.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/&β;1/&γ;23.822020-08-0510.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/&β;1/&γ;23.262020-12-1610.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/&β;1/&γ;23.82020-12-1610.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensEpinephrine--3.12023-04-2610.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.72024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.22024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;22.92024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensEpinephrine--42024-03-0610.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensEpinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8UNLAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1




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