psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D113	15.77	Yes	No	1	0	7
2	L:L:?1	R:R:V117	10.1	Yes	Yes	1	0	6
3	L:L:?1	R:R:F193	12.97	Yes	Yes	1	0	4
4	L:L:?1	R:R:S203	8.72	Yes	No	0	0	5
5	L:L:?1	R:R:S207	4.36	Yes	No	0	0	5
6	L:L:?1	R:R:F289	14.15	Yes	Yes	1	0	6
7	L:L:?1	R:R:F290	7.08	Yes	Yes	1	0	7
8	L:L:?1	R:R:Y308	3.41	Yes	Yes	1	0	5
9	L:L:?1	R:R:N312	17.29	Yes	No	1	0	5
10	L:L:?1	R:R:Y316	6.81	Yes	Yes	1	0	6
11	R:R:V33	R:R:V34	3.21	No	No	0	4	5
12	R:R:L95	R:R:V33	4.47	No	No	0	6	4
13	R:R:G35	R:R:I38	3.53	No	No	0	5	5
14	R:R:G37	R:R:L95	5.13	No	No	0	5	6
15	R:R:A91	R:R:M40	4.83	No	No	0	6	6
16	R:R:M40	R:R:W313	4.65	No	No	0	6	5
17	R:R:I43	R:R:V317	4.61	No	No	0	6	5
18	R:R:V44	R:R:V87	3.21	No	Yes	1	6	7
19	R:R:P88	R:R:V44	5.3	No	No	1	8	6
20	R:R:L80	R:R:V48	4.47	Yes	No	4	7	6
21	R:R:L84	R:R:V48	4.47	No	No	4	5	6
22	R:R:D79	R:R:N51	16.16	No	No	0	9	9
23	R:R:L80	R:R:N51	6.87	Yes	No	0	7	9
24	R:R:F336	R:R:L53	7.31	No	Yes	0	7	6
25	R:R:L340	R:R:L53	6.92	No	Yes	0	6	6
26	R:R:A76	R:R:V54	3.39	No	No	0	9	9
27	R:R:P323	R:R:V54	3.53	No	No	0	9	9
28	R:R:C327	R:R:V54	3.42	No	No	0	7	9
29	R:R:A76	R:R:I55	3.25	No	No	0	9	7
30	R:R:L339	R:R:T56	4.42	No	No	0	6	5
31	R:R:I58	R:R:T73	6.08	No	No	0	7	6
32	R:R:F332	R:R:I58	5.02	Yes	No	0	9	7
33	R:R:K60	R:R:L339	4.23	No	No	0	5	6
34	R:R:F61	R:R:R63	6.41	No	No	0	6	6
35	R:R:E338	R:R:F61	7	No	No	0	4	6
36	R:R:E62	R:R:Q65	3.82	No	No	0	6	8
37	R:R:D331	R:R:R63	17.87	No	No	2	7	6
38	R:R:I334	R:R:R63	10.02	No	No	2	4	6
39	R:R:L64	R:R:N69	4.12	No	Yes	2	8	9
40	R:R:D331	R:R:L64	9.5	No	No	2	7	8
41	R:R:F332	R:R:L64	3.65	Yes	No	2	9	8
42	R:R:Q65	R:R:Y70	10.15	No	No	0	8	4
43	R:R:N69	R:R:T66	11.7	Yes	No	0	9	7
44	R:R:I72	R:R:T68	3.04	No	No	0	8	8
45	R:R:F332	R:R:N69	8.46	Yes	Yes	2	9	9
46	R:R:F71	R:R:V126	5.24	Yes	No	5	8	7
47	R:R:D130	R:R:F71	10.75	No	Yes	0	8	8
48	R:R:A150	R:R:F71	4.16	No	Yes	0	7	8
49	R:R:F71	R:R:I153	3.77	Yes	No	5	8	6
50	R:R:F71	R:R:I154	6.28	Yes	No	0	8	8
51	R:R:S74	R:R:T123	4.8	No	No	0	9	8
52	R:R:I154	R:R:S74	7.74	No	No	0	8	9
53	R:R:S74	R:R:W158	6.18	No	Yes	0	9	9
54	R:R:L75	R:R:T123	8.84	No	No	0	9	8
55	R:R:L124	R:R:L75	4.15	No	No	7	8	9
56	R:R:L75	R:R:N322	6.87	No	No	7	9	9
57	R:R:D79	R:R:S319	10.31	No	No	0	9	9
58	R:R:D79	R:R:P323	3.22	No	No	0	9	9
59	R:R:L80	R:R:L84	5.54	Yes	No	4	7	5
60	R:R:C116	R:R:V81	3.42	No	No	0	7	7
61	R:R:M82	R:R:V86	3.04	Yes	Yes	0	7	7
62	R:R:C116	R:R:M82	6.48	No	Yes	0	7	7
63	R:R:M82	R:R:V117	3.04	Yes	Yes	0	7	6
64	R:R:M82	R:R:S319	4.6	Yes	No	0	7	9
65	R:R:G83	R:R:V87	3.68	No	Yes	0	7	7
66	R:R:A85	R:R:I112	3.25	No	No	0	4	4
67	R:R:V86	R:R:W109	4.9	Yes	Yes	0	7	5
68	R:R:I112	R:R:V86	3.07	No	Yes	0	4	7
69	R:R:D113	R:R:V86	5.84	No	Yes	0	7	7
70	R:R:P88	R:R:V87	3.53	No	Yes	1	8	7
71	R:R:V87	R:R:Y316	3.79	Yes	Yes	1	7	6
72	R:R:F89	R:R:W109	4.01	No	Yes	0	5	5
73	R:R:G90	R:R:W109	4.22	No	Yes	0	7	5
74	R:R:H93	R:R:W99	9.52	No	Yes	0	4	7
75	R:R:T96	R:R:T98	3.14	No	No	0	4	5
76	R:R:T189	R:R:T98	3.14	No	No	0	4	5
77	R:R:F101	R:R:W99	13.03	No	Yes	0	5	7
78	R:R:C106	R:R:W99	6.53	No	Yes	8	9	7
79	R:R:W109	R:R:W99	11.25	Yes	Yes	0	5	7
80	R:R:C191	R:R:W99	3.92	No	Yes	8	9	7
81	R:R:E188	R:R:N103	10.52	No	No	0	3	2
82	R:R:F108	R:R:W105	7.02	No	No	0	5	5
83	R:R:C106	R:R:C191	7.28	No	No	8	9	9
84	R:R:E107	R:R:Y174	7.86	No	Yes	3	5	5
85	R:R:E107	R:R:R175	4.65	No	Yes	3	5	2
86	R:R:F108	R:R:I112	6.28	No	No	0	5	4
87	R:R:F108	R:R:F166	5.36	No	Yes	0	5	4
88	R:R:S111	R:R:S165	3.26	No	Yes	9	6	7
89	R:R:F166	R:R:S111	17.18	Yes	No	9	4	6
90	R:R:I169	R:R:S111	4.64	No	No	0	5	6
91	R:R:D113	R:R:Y316	12.64	No	Yes	1	7	6
92	R:R:S165	R:R:V114	3.23	Yes	No	0	7	5
93	R:R:I169	R:R:V114	3.07	No	No	0	5	5
94	R:R:V114	R:R:Y199	3.79	No	Yes	0	5	6
95	R:R:L115	R:R:W158	4.56	No	Yes	0	5	9
96	R:R:L115	R:R:S165	6.01	No	Yes	0	5	7
97	R:R:I121	R:R:V117	3.07	Yes	Yes	1	7	6
98	R:R:V117	R:R:W286	9.81	Yes	Yes	1	6	8
99	R:R:S161	R:R:T118	3.2	Yes	No	0	8	6
100	R:R:S207	R:R:T118	7.99	No	No	0	5	6
101	R:R:A119	R:R:W158	7.78	No	Yes	6	7	9
102	R:R:A119	R:R:S161	3.42	No	Yes	6	7	8
103	R:R:I121	R:R:P211	3.39	Yes	Yes	0	7	8
104	R:R:F282	R:R:I121	6.28	Yes	Yes	1	9	7
105	R:R:I121	R:R:W286	10.57	Yes	Yes	1	7	8
106	R:R:E122	R:R:V157	7.13	No	No	0	5	7
107	R:R:E122	R:R:V160	4.28	No	No	0	5	4
108	R:R:I127	R:R:T123	3.04	No	No	0	9	8
109	R:R:L124	R:R:N322	6.87	No	No	7	8	9
110	R:R:L124	R:R:Y326	5.86	No	Yes	0	8	9
111	R:R:C125	R:R:P211	3.77	Yes	Yes	0	7	8
112	R:R:C125	R:R:I214	6.55	Yes	No	0	7	6
113	R:R:C125	R:R:M215	4.86	Yes	Yes	0	7	8
114	R:R:I153	R:R:V126	3.07	No	No	5	6	7
115	R:R:I127	R:R:Y326	6.04	No	Yes	0	9	9
116	R:R:A128	R:R:M215	3.22	No	Yes	1	8	8
117	R:R:A128	R:R:Y219	5.34	No	Yes	1	8	9
118	R:R:F133	R:R:V129	5.24	No	No	0	5	6
119	R:R:D130	R:R:L145	8.14	No	Yes	0	8	7
120	R:R:R131	R:R:Y326	4.12	No	Yes	0	9	9
121	R:R:F133	R:R:Y132	5.16	No	Yes	0	5	8
122	R:R:T136	R:R:Y132	13.73	No	Yes	0	7	8
123	R:R:V218	R:R:Y132	7.57	No	Yes	0	6	8
124	R:R:R221	R:R:Y132	3.09	No	Yes	0	5	8
125	R:R:A134	R:R:Y141	9.34	No	No	0	8	7
126	R:R:I135	R:R:V222	4.61	No	No	0	9	8
127	R:R:E225	R:R:T136	5.64	No	No	0	5	7
128	R:R:K140	R:R:S137	3.06	No	No	0	5	6
129	R:R:L145	R:R:Y141	9.38	Yes	No	0	7	7
130	R:R:L144	R:R:L145	4.15	No	Yes	0	4	7
131	R:R:K147	R:R:T146	6.01	No	No	0	1	8
132	R:R:S161	R:R:W158	4.94	Yes	Yes	6	8	9
133	R:R:G162	R:R:S161	3.71	No	Yes	0	4	8
134	R:R:L163	R:R:L167	4.15	No	No	0	4	5
135	R:R:T164	R:R:V206	6.35	No	No	0	5	4
136	R:R:F166	R:R:S165	6.61	Yes	Yes	9	4	7
137	R:R:F166	R:R:Q170	7.03	Yes	No	0	4	4
138	R:R:L167	R:R:P168	4.93	No	No	0	5	5
139	R:R:P168	R:R:Y199	5.56	No	Yes	0	5	6
140	R:R:I169	R:R:Y174	10.88	No	Yes	0	5	5
141	R:R:M171	R:R:W173	5.82	No	No	0	4	4
142	R:R:H172	R:R:R175	22.57	No	Yes	0	4	2
143	R:R:R175	R:R:Y174	3.09	Yes	Yes	3	2	5
144	R:R:Y174	R:R:Y185	8.94	Yes	No	3	5	1
145	R:R:Y174	R:R:Y199	4.96	Yes	Yes	0	5	6
146	R:R:R175	R:R:Y185	9.26	Yes	No	3	2	1
147	R:R:A176	R:R:H178	4.39	No	No	0	1	2
148	R:R:E180	R:R:H178	22.16	No	No	0	3	2
149	R:R:E180	R:R:F194	3.5	No	Yes	0	3	1
150	R:R:A181	R:R:F194	4.16	No	Yes	0	4	1
151	R:R:C184	R:R:F194	9.78	No	Yes	0	1	1
152	R:R:F194	R:R:Y185	4.13	Yes	No	0	1	1
153	R:R:E187	R:R:T189	9.88	No	No	0	7	4
154	R:R:F193	R:R:T195	7.78	Yes	No	0	4	3
155	R:R:F193	R:R:Y308	4.13	Yes	Yes	1	4	5
156	R:R:T195	R:R:Y199	6.24	No	Yes	0	3	6
157	R:R:A200	R:R:T195	3.36	No	No	0	5	3
158	R:R:A198	R:R:N196	3.13	No	No	0	4	4
159	R:R:Q197	R:R:V297	5.73	No	No	0	2	5
160	R:R:S203	R:R:Y199	7.63	No	Yes	0	5	6
161	R:R:A200	R:R:V297	3.39	No	No	0	5	5
162	R:R:S204	R:R:Y209	5.09	No	Yes	10	5	5
163	R:R:I294	R:R:S204	6.19	Yes	No	10	6	5
164	R:R:F208	R:R:Y209	6.19	Yes	Yes	0	8	5
165	R:R:F208	R:R:L212	9.74	Yes	No	0	8	7
166	R:R:F208	R:R:F282	8.57	Yes	Yes	0	8	9
167	R:R:F208	R:R:L287	7.31	Yes	No	0	8	6
168	R:R:F208	R:R:F290	19.29	Yes	Yes	0	8	7
169	R:R:I291	R:R:Y209	3.63	No	Yes	0	6	5
170	R:R:I294	R:R:Y209	4.84	Yes	Yes	10	6	5
171	R:R:P211	R:R:V210	3.53	Yes	No	0	8	5
172	R:R:M215	R:R:Y219	3.59	Yes	Yes	1	8	9
173	R:R:F282	R:R:M215	4.98	Yes	Yes	1	9	8
174	R:R:F217	R:R:R221	12.83	No	No	0	4	5
175	R:R:L275	R:R:Y219	5.86	No	Yes	0	8	9
176	R:R:I278	R:R:Y219	4.84	No	Yes	0	8	9
177	R:R:M279	R:R:Y219	3.59	No	Yes	0	8	9
178	R:R:Q224	R:R:R221	3.5	No	No	0	3	5
179	R:R:F223	R:R:K227	7.44	No	No	0	6	6
180	R:R:F223	R:R:L272	8.53	No	No	0	6	7
181	R:R:F223	R:R:L275	3.65	No	No	0	6	8
182	R:R:Q231	R:R:R228	15.19	No	No	0	5	4
183	R:R:K232	R:R:R228	11.14	No	No	0	4	4
184	R:R:I325	R:R:T281	4.56	No	No	0	8	6
185	R:R:F282	R:R:W286	4.01	Yes	Yes	1	9	8
186	R:R:C285	R:R:N318	11.02	No	No	0	9	9
187	R:R:F289	R:R:W286	7.02	Yes	Yes	1	6	8
188	R:R:F290	R:R:W286	9.02	Yes	Yes	1	7	8
189	R:R:G315	R:R:W286	8.44	No	Yes	0	7	8
190	R:R:N318	R:R:W286	7.91	No	Yes	0	9	8
191	R:R:L287	R:R:P288	3.28	No	No	0	6	9
192	R:R:L311	R:R:P288	3.28	No	No	0	5	9
193	R:R:F289	R:R:F290	7.5	Yes	Yes	1	6	7
194	R:R:F289	R:R:Y308	9.28	Yes	Yes	1	6	5
195	R:R:F289	R:R:N312	13.29	Yes	No	1	6	5
196	R:R:I303	R:R:V292	6.14	Yes	No	0	3	5
197	R:R:L311	R:R:V292	7.45	No	No	0	5	5
198	R:R:H296	R:R:N293	6.38	Yes	No	1	3	5
199	R:R:N293	R:R:Y308	4.65	No	Yes	1	5	5
200	R:R:I303	R:R:V295	4.61	Yes	No	0	3	4
201	R:R:H296	R:R:V297	4.15	Yes	No	0	3	5
202	R:R:H296	R:R:I303	3.98	Yes	Yes	0	3	3
203	R:R:H296	R:R:Y308	7.62	Yes	Yes	1	3	5
204	R:R:N301	R:R:Q299	3.96	No	No	11	2	2
205	R:R:L302	R:R:Q299	6.65	No	No	11	1	2
206	R:R:L302	R:R:N301	9.61	No	No	11	1	2
207	R:R:E306	R:R:R304	5.82	No	No	0	2	4
208	R:R:E306	R:R:K305	5.4	No	No	0	2	2
209	R:R:N312	R:R:Y316	15.12	No	Yes	1	5	6
210	R:R:W313	R:R:Y316	12.54	No	Yes	0	5	6
211	R:R:I325	R:R:Y326	3.63	No	Yes	0	8	9
212	R:R:C327	R:R:F332	6.98	No	Yes	0	7	9
213	R:R:P330	R:R:S329	3.56	No	No	0	5	8
214	R:R:D331	R:R:I334	4.2	No	No	2	7	4
215	R:R:F332	R:R:F336	4.29	Yes	No	0	9	7
216	R:R:Q337	R:R:R333	3.5	No	No	0	4	9
217	R:R:L80	R:R:V52	2.98	Yes	No	0	7	3
218	R:R:L145	R:R:V67	2.98	Yes	No	0	7	6
219	R:R:L212	R:R:V216	2.98	No	No	0	7	5
220	R:R:L302	R:R:V295	2.98	No	No	0	1	4
221	R:R:L287	R:R:T283	2.95	No	No	0	6	7
222	R:R:I43	R:R:I47	2.94	No	No	0	6	8
223	R:R:I309	R:R:I94	2.94	No	No	0	3	5
224	R:R:I201	R:R:I294	2.94	No	Yes	0	5	6
225	R:R:I294	R:R:I298	2.94	Yes	No	0	6	4
226	R:R:E237	R:R:S236	2.87	No	No	0	3	4
227	R:R:I38	R:R:L42	2.85	No	No	0	5	5
228	R:R:L95	R:R:M40	2.83	No	No	0	6	6
229	R:R:I47	R:R:N51	2.83	No	No	0	8	9
230	R:R:I72	R:R:N69	2.83	No	Yes	0	8	9
231	R:R:L167	R:R:M171	2.83	No	No	0	5	4
232	R:R:L339	R:R:L53	2.77	No	Yes	0	6	6
233	R:R:A57	R:R:F336	2.77	No	No	0	8	7
234	R:R:A335	R:R:F61	2.77	No	No	0	7	6
235	R:R:D192	R:R:K305	2.77	No	No	0	3	2
236	R:R:E225	R:R:I135	2.73	No	No	0	5	9
237	R:R:F332	R:R:S329	2.64	Yes	No	0	9	8
238	R:R:A78	R:R:W158	2.59	No	Yes	0	8	9
239	R:R:F193	R:R:T110	2.59	Yes	No	0	4	4
240	R:R:F321	R:R:T281	2.59	No	No	0	6	6
241	R:R:F49	R:R:L53	2.44	No	Yes	0	4	6
242	R:R:D192	R:R:F194	2.39	No	Yes	0	3	1
243	R:R:I309	R:R:W313	2.35	No	No	0	3	5
244	R:R:R151	R:R:Y70	2.06	No	No	0	3	4
245	R:R:G35	R:R:V34	1.84	No	No	0	5	5
246	R:R:A226	R:R:A271	1.79	No	No	0	8	8
247	R:R:P138	R:R:S137	1.78	No	No	0	8	6
248	R:R:G320	R:R:I47	1.76	No	No	0	7	8
249	R:R:G315	R:R:I314	1.76	No	No	0	7	7
250	R:R:G37	R:R:M36	1.75	No	No	0	5	5
251	R:R:G280	R:R:M279	1.75	No	No	0	5	8
252	R:R:G50	R:R:L53	1.71	No	Yes	0	8	6
253	R:R:C77	R:R:V81	1.71	No	No	0	6	7
254	R:R:C125	R:R:V129	1.71	Yes	No	0	7	6
255	R:R:G102	R:R:N103	1.7	No	No	0	7	2
256	R:R:C190	R:R:T189	1.69	No	No	0	3	4
257	R:R:L324	R:R:P323	1.64	No	No	0	6	9
258	R:R:S120	R:R:S319	1.63	No	No	0	9	9
259	R:R:T164	R:R:V160	1.59	No	No	0	5	4
260	R:R:T100	R:R:T98	1.57	No	No	0	2	5
261	R:R:E122	R:R:P211	1.57	No	Yes	0	5	8
262	R:R:I205	R:R:S204	1.55	No	No	0	4	5
263	R:R:I43	R:R:V39	1.54	No	No	0	6	5
264	R:R:I303	R:R:V307	1.54	Yes	No	0	3	4
265	R:R:I278	R:R:T274	1.52	No	No	0	8	8
266	R:R:I277	R:R:T281	1.52	No	No	0	7	6
267	R:R:F101	R:R:G102	1.51	No	No	0	5	7
268	R:R:K149	R:R:T146	1.5	No	No	0	5	8
269	R:R:N148	R:R:T146	1.46	No	No	0	4	8
270	R:R:I153	R:R:K149	1.45	No	No	0	6	5
271	R:R:I314	R:R:L310	1.43	No	No	0	7	5
272	R:R:K232	R:R:Q229	1.36	No	No	0	4	7
273	R:R:A150	R:R:Y70	1.33	No	No	0	7	4
274	R:R:N183	R:R:Q179	1.32	No	No	0	3	3
275	R:R:N196	R:R:Q197	1.32	No	No	0	4	2
276	R:R:H269	R:R:K270	1.31	No	No	0	5	7
277	R:R:R328	R:R:T274	1.29	No	No	0	7	8
278	R:R:E187	R:R:E188	1.27	No	No	0	7	3
279	R:R:F139	R:R:K140	1.24	No	No	0	6	5
280	R:R:F104	R:R:N103	1.21	No	No	0	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.066	10	1	0
2	R:R:L53	4.23	5	0	6
3	R:R:N69	6.7775	4	2	9
4	R:R:F71	6.04	5	5	8
5	R:R:L80	4.965	4	4	7
6	R:R:M82	4.29	4	0	7
7	R:R:V86	4.2125	4	0	7
8	R:R:V87	3.5525	4	1	7
9	R:R:W99	8.85	5	8	7
10	R:R:W109	6.095	4	0	5
11	R:R:V117	6.505	4	1	6
12	R:R:I121	5.8275	4	1	7
13	R:R:C125	4.2225	4	0	7
14	R:R:Y132	7.3875	4	0	8
15	R:R:L145	6.1625	4	0	7
16	R:R:W158	5.21	5	6	9
17	R:R:S161	3.8175	4	6	8
18	R:R:S165	4.7775	4	9	7
19	R:R:F166	9.045	4	9	4
20	R:R:Y174	7.146	5	3	5
21	R:R:R175	9.8925	4	3	2
22	R:R:F193	6.8675	4	1	4
23	R:R:F194	4.792	5	0	1
24	R:R:Y199	5.636	5	0	6
25	R:R:F208	10.22	5	0	8
26	R:R:Y209	4.9375	4	10	5
27	R:R:P211	3.065	4	0	8
28	R:R:M215	4.1625	4	1	8
29	R:R:Y219	4.644	5	1	9
30	R:R:F282	5.96	4	1	9
31	R:R:W286	8.11143	7	1	8
32	R:R:F289	10.248	5	1	6
33	R:R:F290	10.7225	4	1	7
34	R:R:I294	4.2275	4	10	6
35	R:R:H296	5.5325	4	1	3
36	R:R:I303	4.0675	4	0	3
37	R:R:Y308	5.818	5	1	5
38	R:R:Y316	10.18	5	1	6
39	R:R:Y326	4.9125	4	0	9
40	R:R:F332	5.17333	6	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y316	38.8177	6.81	Yes	Yes	1	0	6
2	R:R:W313	R:R:Y316	38.911	12.54	No	Yes	0	5	6
3	R:R:M40	R:R:W313	30.1501	4.65	No	No	0	6	5
4	R:R:L95	R:R:M40	24.3067	2.83	No	No	0	6	6
5	R:R:L95	R:R:V33	15.3592	4.47	No	No	0	6	4
6	R:R:V33	R:R:V34	12.4756	3.21	No	No	0	4	5
7	L:L:?1	R:R:V117	93.0964	10.1	Yes	Yes	1	0	6
8	R:R:M82	R:R:V117	99.7795	3.04	Yes	Yes	0	7	6
9	R:R:M82	R:R:S319	100	4.6	Yes	No	0	7	9
10	R:R:D79	R:R:S319	96.1666	10.31	No	No	0	9	9
11	R:R:D79	R:R:N51	25.6043	16.16	No	No	0	9	9
12	R:R:I47	R:R:N51	13.0099	2.83	No	No	0	8	9
13	R:R:V87	R:R:Y316	12.4756	3.79	Yes	Yes	1	7	6
14	R:R:L80	R:R:N51	10.4402	6.87	Yes	No	0	7	9
15	R:R:D79	R:R:P323	73.8699	3.22	No	No	0	9	9
16	R:R:P323	R:R:V54	69.5955	3.53	No	No	0	9	9
17	R:R:C327	R:R:V54	63.0566	3.42	No	No	0	7	9
18	R:R:C327	R:R:F332	60.843	6.98	No	Yes	0	7	9
19	R:R:F332	R:R:F336	23.1024	4.29	Yes	No	0	9	7
20	R:R:F336	R:R:L53	18.0816	7.31	No	Yes	0	7	6
21	R:R:F332	R:R:L64	17.8611	3.65	Yes	No	2	9	8
22	R:R:D331	R:R:L64	15.5627	9.5	No	No	2	7	8
23	R:R:D331	R:R:R63	10.4062	17.87	No	No	2	7	6
24	L:L:?1	R:R:S207	75.2184	4.36	Yes	No	0	0	5
25	R:R:S207	R:R:T118	73.3271	7.99	No	No	0	5	6
26	R:R:S161	R:R:T118	71.5291	3.2	Yes	No	0	8	6
27	R:R:S161	R:R:W158	66.89	4.94	Yes	Yes	6	8	9
28	R:R:S74	R:R:W158	84.4118	6.18	No	Yes	0	9	9
29	R:R:I154	R:R:S74	53.7274	7.74	No	No	0	8	9
30	R:R:F71	R:R:I154	51.0389	6.28	Yes	No	0	8	8
31	R:R:A150	R:R:F71	14.7909	4.16	No	Yes	0	7	8
32	R:R:A150	R:R:Y70	11.865	1.33	No	No	0	7	4
33	R:R:F332	R:R:N69	10.1857	8.46	Yes	Yes	2	9	9
34	R:R:D130	R:R:F71	17.4455	10.75	No	Yes	0	8	8
35	R:R:F71	R:R:I153	14.7485	3.77	Yes	No	5	8	6
36	R:R:S74	R:R:T123	31.7361	4.8	No	No	0	9	8
37	L:L:?1	R:R:D113	19.235	15.77	Yes	No	1	0	7
38	R:R:D113	R:R:V86	29.6582	5.84	No	Yes	0	7	7
39	R:R:I112	R:R:V86	17.5049	3.07	No	Yes	0	4	7
40	R:R:V86	R:R:W109	40.1153	4.9	Yes	Yes	0	7	5
41	R:R:W109	R:R:W99	33.9157	11.25	Yes	Yes	0	5	7
42	R:R:F101	R:R:W99	25.3668	13.03	No	Yes	0	5	7
43	R:R:F101	R:R:G102	23.1448	1.51	No	No	0	5	7
44	R:R:G102	R:R:N103	20.9058	1.7	No	No	0	7	2
45	R:R:E188	R:R:N103	16.3769	10.52	No	No	0	3	2
46	R:R:E187	R:R:E188	14.087	1.27	No	No	0	7	3
47	R:R:E187	R:R:T189	11.7802	9.88	No	No	0	7	4
48	R:R:F108	R:R:I112	15.4185	6.28	No	No	0	5	4
49	L:L:?1	R:R:S203	54.0158	8.72	Yes	No	0	0	5
50	R:R:S203	R:R:Y199	52.3535	7.63	No	Yes	0	5	6
51	R:R:Y174	R:R:Y199	40.8532	4.96	Yes	Yes	0	5	6
52	R:R:F108	R:R:F166	13.5442	5.36	No	Yes	0	5	4
53	R:R:V114	R:R:Y199	20.4817	3.79	No	Yes	0	5	6
54	R:R:S165	R:R:V114	20.4054	3.23	Yes	No	0	7	5
55	R:R:F166	R:R:S165	10.0416	6.61	Yes	Yes	9	4	7
56	R:R:I169	R:R:Y174	14.2397	10.88	No	Yes	0	5	5
57	R:R:L115	R:R:S165	28.7168	6.01	No	Yes	0	5	7
58	R:R:L115	R:R:W158	27.6906	4.56	No	Yes	0	5	9
59	R:R:I121	R:R:V117	56.5431	3.07	Yes	Yes	1	7	6
60	R:R:V117	R:R:W286	39.3945	9.81	Yes	Yes	1	6	8
61	L:L:?1	R:R:F289	16.2836	14.15	Yes	Yes	1	0	6
62	R:R:F289	R:R:W286	25.7739	7.02	Yes	Yes	1	6	8
63	L:L:?1	R:R:F290	47.9094	7.08	Yes	Yes	1	0	7
64	R:R:F290	R:R:W286	22.2458	9.02	Yes	Yes	1	7	8
65	R:R:I121	R:R:P211	35.6967	3.39	Yes	Yes	0	7	8
66	R:R:F282	R:R:I121	25.3838	6.28	Yes	Yes	1	9	7
67	R:R:F282	R:R:W286	52.4892	4.01	Yes	Yes	1	9	8
68	R:R:F208	R:R:F290	39.8355	19.29	Yes	Yes	0	8	7
69	R:R:F208	R:R:F282	26.9952	8.57	Yes	Yes	0	8	9
70	R:R:E122	R:R:P211	10.5928	1.57	No	Yes	0	5	8
71	R:R:I127	R:R:T123	20.1764	3.04	No	No	0	9	8
72	R:R:I127	R:R:Y326	17.2929	6.04	No	Yes	0	9	9
73	R:R:C125	R:R:P211	23.942	3.77	Yes	Yes	0	7	8
74	R:R:F282	R:R:M215	72.5638	4.98	Yes	Yes	1	9	8
75	R:R:M215	R:R:Y219	58.5447	3.59	Yes	Yes	1	8	9
76	R:R:C125	R:R:V129	24.5611	1.71	Yes	No	0	7	6
77	R:R:F133	R:R:V129	22.3984	5.24	No	No	0	5	6
78	R:R:D130	R:R:L145	14.7825	8.14	No	Yes	0	8	7
79	R:R:F133	R:R:Y132	20.2188	5.16	No	Yes	0	5	8
80	R:R:I153	R:R:K149	11.865	1.45	No	No	0	6	5
81	R:R:P168	R:R:Y199	13.6036	5.56	No	Yes	0	5	6
82	R:R:L167	R:R:P168	10.9151	4.93	No	No	0	5	5
83	R:R:Y174	R:R:Y185	35.2387	8.94	Yes	No	3	5	1
84	R:R:F194	R:R:Y185	32.3721	4.13	Yes	No	0	1	1
85	R:R:E180	R:R:F194	10.067	3.5	No	Yes	0	3	1
86	L:L:?1	R:R:Y308	23.5603	3.41	Yes	Yes	1	0	5
87	R:R:H296	R:R:Y308	29.6497	7.62	Yes	Yes	1	3	5
88	R:R:H296	R:R:V297	11.1865	4.15	Yes	No	0	3	5
89	R:R:F208	R:R:Y209	24.0777	6.19	Yes	Yes	0	8	5
90	R:R:I294	R:R:Y209	10.3554	4.84	Yes	Yes	10	6	5
91	R:R:F208	R:R:L287	13.8495	7.31	Yes	No	0	8	6
92	R:R:L275	R:R:Y219	23.942	5.86	No	Yes	0	8	9
93	R:R:I278	R:R:Y219	17.2504	4.84	No	Yes	0	8	9
94	R:R:M279	R:R:Y219	12.0007	3.59	No	Yes	0	8	9
95	R:R:F223	R:R:L275	17.9798	3.65	No	No	0	6	8
96	R:R:I325	R:R:Y326	11.865	3.63	No	Yes	0	8	9
97	R:R:G315	R:R:W286	12.0007	8.44	No	Yes	0	7	8
98	R:R:H296	R:R:I303	21.6521	3.98	Yes	Yes	0	3	3
99	R:R:I303	R:R:V295	12.0346	4.61	Yes	No	0	3	4
100	R:R:D192	R:R:F194	12.976	2.39	No	Yes	0	3	1
101	R:R:I278	R:R:T274	11.2713	1.52	No	No	0	8	8
102	R:R:D113	R:R:Y316	11.5936	12.64	No	Yes	1	7	6
103	R:R:M82	R:R:V86	31.3883	3.04	Yes	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D113	15.77	1	Yes	No	0	7	0	1
L:L:?1	R:R:V117	10.1	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F193	12.97	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S203	8.72	1	Yes	No	0	5	0	1
L:L:?1	R:R:S207	4.36	1	Yes	No	0	5	0	1
L:L:?1	R:R:F289	14.15	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F290	7.08	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y308	3.41	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N312	17.29	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y316	6.81	1	Yes	Yes	0	6	0	1
R:R:M82	R:R:V86	3.04	0	Yes	Yes	7	7	2	2
R:R:M82	R:R:V117	3.04	0	Yes	Yes	7	6	2	1
R:R:D113	R:R:V86	5.84	1	No	Yes	7	7	1	2
R:R:V87	R:R:Y316	3.79	1	Yes	Yes	7	6	2	1
R:R:D113	R:R:Y316	12.64	1	No	Yes	7	6	1	1
R:R:I121	R:R:V117	3.07	1	Yes	Yes	7	6	2	1
R:R:V117	R:R:W286	9.81	1	Yes	Yes	6	8	1	2
R:R:S207	R:R:T118	7.99	0	No	No	5	6	1	2
R:R:I121	R:R:W286	10.57	1	Yes	Yes	7	8	2	2
R:R:F193	R:R:T195	7.78	1	Yes	No	4	3	1	2
R:R:F193	R:R:Y308	4.13	1	Yes	Yes	4	5	1	1
R:R:T195	R:R:Y199	6.24	0	No	Yes	3	6	2	2
R:R:S203	R:R:Y199	7.63	0	No	Yes	5	6	1	2
R:R:F208	R:R:F290	19.29	0	Yes	Yes	8	7	2	1
R:R:F289	R:R:W286	7.02	1	Yes	Yes	6	8	1	2
R:R:F290	R:R:W286	9.02	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:F290	7.5	1	Yes	Yes	6	7	1	1
R:R:F289	R:R:Y308	9.28	1	Yes	Yes	6	5	1	1
R:R:F289	R:R:N312	13.29	1	Yes	No	6	5	1	1
R:R:H296	R:R:N293	6.38	1	Yes	No	3	5	2	2
R:R:N293	R:R:Y308	4.65	1	No	Yes	5	5	2	1
R:R:H296	R:R:Y308	7.62	1	Yes	Yes	3	5	2	1
R:R:N312	R:R:Y316	15.12	1	No	Yes	5	6	1	1
R:R:W313	R:R:Y316	12.54	0	No	Yes	5	6	2	1
R:R:F193	R:R:T110	2.59	1	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GEA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	252
Number of Links	280
Number of Hubs	40
Number of Links mediated by Hubs	146
Number of Communities	11
Number of Nodes involved in Communities	54
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	104
Number Of Links MetaPath	103
Number of Shortest Paths	41632
Length Of Smallest Path	3
Average Path Length	11.872
Length of Longest Path	25
Minimum Path Strength	1.405
Average Path Strength	6.05672
Maximum Path Strength	16.53
Minimum Path Correlation	0.71
Average Path Correlation	0.928305
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	57.3461
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.3746
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amide binding • amyloid-beta binding • binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold
Gene Ontology	Biological Process	• multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • regulation of biological process • bone mineralization • animal organ development • biological regulation • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • cellular component organization • autophagosome maturation • cellular component organization or biogenesis • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • protein-containing complex • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • cell periphery • apical part of cell • plasma membrane • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	G1I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	G1I
Name	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier
Formula	C11 H15 N O3
Molecular Weight	209.242
SMILES
PubChem	12353638
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	2
Total Bonds	31
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>8GEA_nogp_Chain_R E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L T K T W T F G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S F L P I Q M H W Y R A T H Q E A I N C Y A E E T C C D F F T N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E G R H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q D N L I R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	doi.org/10.1126/science.aaw8981
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	GTPL11074	-	3.1	2020-03-25	doi.org/10.1038/s41589-020-0549-2
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	Cmpd-15	-	2.7	2017-08-16	doi.org/10.1038/nature23652
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	doi.org/10.1016/j.str.2008.05.001
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	3.16	2010-08-11	doi.org/10.1021/ja105108q
	2R4R	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	2R4S	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	doi.org/10.1038/nature08650
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	doi.org/10.1038/nature09648
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.5	2011-01-12	doi.org/10.1038/nature09665
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	doi.org/10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	doi.org/10.1038/nature10361
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	doi.org/10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.1	2013-09-25	doi.org/10.1038/nature12572
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	L-Epinephrine	-	-	3.2	2013-09-25	doi.org/10.1038/nature12572
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-07-13	doi.org/10.1038/nature18636
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-08-17	doi.org/10.1038/nprot.2017.057
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	doi.org/10.1038/s41589-018-0145-x
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Formoterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	35V	-	-	3.3	2014-07-23	doi.org/10.1073/pnas.1410415111
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Noradrenaline	-	-	3.49	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHV	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.95	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.5	2024-11-13	doi.org/10.1073/pnas.2414544121
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carvedilol	-	-	2.5	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	S-Propranolol	-	-	2.9	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	doi.org/10.1107/S2052252519013137
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.48	2016-01-13	doi.org/10.1107/S2059798315021683
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.8	2016-01-13	doi.org/10.1107/S2059798315021683
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.99	2012-10-24	doi.org/10.1371/journal.pone.0046039
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971

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