psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W109	4.48	Yes	Yes	0	0	5
2	L:L:?1	R:R:D113	20.47	Yes	No	1	0	7
3	L:L:?1	R:R:V114	14.65	Yes	No	0	0	5
4	L:L:?1	R:R:V117	5.86	Yes	No	0	0	6
5	L:L:?1	R:R:F193	19.97	Yes	No	0	0	4
6	L:L:?1	R:R:S203	9.85	Yes	No	0	0	5
7	L:L:?1	R:R:S207	4.92	Yes	No	0	0	5
8	L:L:?1	R:R:F289	7.99	Yes	Yes	1	0	6
9	L:L:?1	R:R:F290	5.59	Yes	Yes	1	0	7
10	L:L:?1	R:R:N293	8.1	Yes	No	0	0	5
11	L:L:?1	R:R:I309	3.74	Yes	No	0	0	3
12	L:L:?1	R:R:N312	11.71	Yes	No	1	0	5
13	R:R:D29	R:R:E30	6.5	No	No	0	5	3
14	R:R:D29	R:R:V31	5.84	No	No	0	5	2
15	R:R:V31	R:R:W32	3.68	No	No	0	2	3
16	R:R:G35	R:R:V34	3.68	No	No	0	5	5
17	R:R:M36	R:R:M40	5.78	No	No	0	5	6
18	R:R:A91	R:R:M40	4.83	No	No	0	6	6
19	R:R:M40	R:R:W313	6.98	No	Yes	0	6	5
20	R:R:I43	R:R:W313	4.7	No	Yes	0	6	5
21	R:R:I47	R:R:S319	9.29	No	No	0	8	9
22	R:R:L80	R:R:V48	4.47	Yes	No	7	7	6
23	R:R:L84	R:R:V48	4.47	No	No	7	5	6
24	R:R:G50	R:R:P323	4.06	No	No	0	8	9
25	R:R:D79	R:R:N51	6.73	Yes	Yes	0	9	9
26	R:R:L80	R:R:N51	6.87	Yes	Yes	0	7	9
27	R:R:N51	R:R:P323	6.52	Yes	No	0	9	9
28	R:R:L80	R:R:V52	4.47	Yes	No	0	7	3
29	R:R:F336	R:R:L53	7.31	Yes	No	0	7	6
30	R:R:C327	R:R:V54	5.12	No	No	0	7	9
31	R:R:I58	R:R:L64	4.28	No	No	4	7	8
32	R:R:F332	R:R:I58	5.02	Yes	No	4	9	7
33	R:R:A335	R:R:F61	8.32	No	No	0	7	6
34	R:R:E338	R:R:F61	8.16	No	No	0	4	6
35	R:R:F61	R:R:L339	3.65	No	No	0	6	6
36	R:R:D331	R:R:R63	11.91	No	No	0	7	6
37	R:R:F332	R:R:L64	20.7	Yes	No	4	9	8
38	R:R:N69	R:R:T66	10.24	No	No	0	9	7
39	R:R:L145	R:R:V67	4.47	No	No	0	7	6
40	R:R:D130	R:R:T68	8.67	No	No	3	8	8
41	R:R:T68	R:R:Y141	4.99	No	No	3	8	7
42	R:R:I72	R:R:N69	4.25	No	No	0	8	9
43	R:R:F332	R:R:N69	7.25	Yes	No	0	9	9
44	R:R:F71	R:R:V126	7.87	Yes	No	3	8	7
45	R:R:D130	R:R:F71	8.36	No	Yes	3	8	8
46	R:R:F71	R:R:L145	4.87	Yes	No	0	8	7
47	R:R:F71	R:R:I153	6.28	Yes	No	3	8	6
48	R:R:F71	R:R:I154	7.54	Yes	No	0	8	8
49	R:R:S74	R:R:T123	6.4	No	No	0	9	8
50	R:R:I154	R:R:S74	7.74	No	No	0	8	9
51	R:R:S74	R:R:W158	6.18	No	No	0	9	9
52	R:R:D79	R:R:L75	4.07	Yes	Yes	2	9	9
53	R:R:L75	R:R:T123	4.42	Yes	No	0	9	8
54	R:R:L124	R:R:L75	5.54	No	Yes	2	8	9
55	R:R:L75	R:R:N322	6.87	Yes	Yes	2	9	9
56	R:R:D79	R:R:S120	7.36	Yes	No	0	9	9
57	R:R:D79	R:R:S319	11.78	Yes	No	0	9	9
58	R:R:D79	R:R:N322	6.73	Yes	Yes	2	9	9
59	R:R:L80	R:R:L84	6.92	Yes	No	7	7	5
60	R:R:M82	R:R:V86	6.09	Yes	No	1	7	7
61	R:R:C116	R:R:M82	6.48	No	Yes	0	7	7
62	R:R:M82	R:R:Y316	4.79	Yes	Yes	1	7	6
63	R:R:M82	R:R:S319	7.67	Yes	No	0	7	9
64	R:R:G83	R:R:V87	3.68	No	Yes	0	7	7
65	R:R:D113	R:R:V86	7.3	No	No	1	7	7
66	R:R:V86	R:R:Y316	6.31	No	Yes	1	7	6
67	R:R:V87	R:R:W313	3.68	Yes	Yes	1	7	5
68	R:R:V87	R:R:Y316	5.05	Yes	Yes	1	7	6
69	R:R:F89	R:R:W109	11.02	No	Yes	0	5	5
70	R:R:H93	R:R:W99	9.52	No	Yes	0	4	7
71	R:R:F101	R:R:W99	4.01	No	Yes	0	5	7
72	R:R:C106	R:R:W99	15.67	No	Yes	8	9	7
73	R:R:W109	R:R:W99	8.43	Yes	Yes	0	5	7
74	R:R:C191	R:R:W99	3.92	No	Yes	8	9	7
75	R:R:F101	R:R:W105	6.01	No	No	0	5	5
76	R:R:E107	R:R:N103	3.94	No	No	0	5	2
77	R:R:E188	R:R:N103	3.94	No	No	0	3	2
78	R:R:F104	R:R:W105	5.01	No	No	0	1	5
79	R:R:C106	R:R:C191	7.28	No	No	8	9	9
80	R:R:E107	R:R:H172	7.39	No	No	0	5	4
81	R:R:F108	R:R:I112	5.02	No	No	9	5	4
82	R:R:F108	R:R:F166	4.29	No	Yes	9	5	4
83	R:R:I169	R:R:T110	4.56	No	No	0	5	4
84	R:R:F166	R:R:S111	7.93	Yes	No	0	4	6
85	R:R:I169	R:R:S111	7.74	No	No	0	5	6
86	R:R:F166	R:R:I112	3.77	Yes	No	9	4	4
87	R:R:D113	R:R:Y316	8.05	No	Yes	1	7	6
88	R:R:L115	R:R:S165	6.01	No	No	0	5	7
89	R:R:F166	R:R:L115	4.87	Yes	No	0	4	5
90	R:R:V117	R:R:W286	13.48	No	Yes	0	6	8
91	R:R:S161	R:R:T118	6.4	No	No	0	8	6
92	R:R:T118	R:R:T164	4.71	No	No	0	6	5
93	R:R:S207	R:R:T118	4.8	No	No	0	5	6
94	R:R:A119	R:R:W158	6.48	No	No	0	7	9
95	R:R:F282	R:R:I121	7.54	No	No	0	9	7
96	R:R:I121	R:R:W286	7.05	No	Yes	0	7	8
97	R:R:E122	R:R:V157	5.7	No	No	0	5	7
98	R:R:E122	R:R:V160	7.13	No	No	0	5	4
99	R:R:L124	R:R:N322	6.87	No	Yes	2	8	9
100	R:R:L124	R:R:Y326	9.38	No	Yes	2	8	9
101	R:R:C125	R:R:P211	3.77	No	No	0	7	8
102	R:R:C125	R:R:I214	6.55	No	No	0	7	6
103	R:R:I153	R:R:V126	4.61	No	No	3	6	7
104	R:R:I127	R:R:R131	3.76	No	No	0	9	9
105	R:R:A128	R:R:Y219	6.67	No	Yes	0	8	9
106	R:R:D130	R:R:Y141	10.34	No	No	3	8	7
107	R:R:T136	R:R:Y132	7.49	Yes	Yes	6	7	8
108	R:R:R221	R:R:Y132	12.35	No	Yes	6	5	8
109	R:R:V222	R:R:Y132	3.79	No	Yes	0	8	8
110	R:R:A134	R:R:Y141	9.34	No	No	0	8	7
111	R:R:I135	R:R:K232	5.82	No	No	0	9	4
112	R:R:R221	R:R:T136	3.88	No	Yes	6	5	7
113	R:R:E225	R:R:T136	4.23	Yes	Yes	6	5	7
114	R:R:K140	R:R:S137	10.71	No	No	0	5	6
115	R:R:K149	R:R:T146	4.5	No	No	0	5	8
116	R:R:K149	R:R:N148	12.59	No	No	0	5	4
117	R:R:N148	R:R:V152	4.43	No	No	0	4	4
118	R:R:I159	R:R:L155	5.71	No	No	0	4	3
119	R:R:T164	R:R:V206	7.93	No	No	0	5	4
120	R:R:P168	R:R:Y199	5.56	No	Yes	0	5	6
121	R:R:I169	R:R:Y174	6.04	No	Yes	0	5	5
122	R:R:M171	R:R:W173	10.47	No	No	0	4	4
123	R:R:H172	R:R:R175	9.03	No	Yes	0	4	2
124	R:R:R175	R:R:Y174	9.26	Yes	Yes	5	2	5
125	R:R:Y174	R:R:Y185	6.95	Yes	No	5	5	1
126	R:R:T195	R:R:Y174	4.99	No	Yes	5	3	5
127	R:R:Y174	R:R:Y199	4.96	Yes	Yes	5	5	6
128	R:R:A176	R:R:R175	4.15	No	Yes	0	1	2
129	R:R:R175	R:R:Y185	7.2	Yes	No	5	2	1
130	R:R:H178	R:R:T177	4.11	No	No	0	2	3
131	R:R:A181	R:R:F194	5.55	No	No	0	4	1
132	R:R:C184	R:R:C190	7.28	No	No	0	1	3
133	R:R:C184	R:R:D192	4.67	No	No	0	1	3
134	R:R:F194	R:R:Y185	6.19	No	No	0	1	1
135	R:R:E187	R:R:T189	7.06	No	No	0	4	4
136	R:R:D192	R:R:F194	8.36	No	No	0	3	1
137	R:R:D192	R:R:K305	9.68	No	No	0	3	2
138	R:R:F193	R:R:T195	11.67	No	No	0	4	3
139	R:R:T195	R:R:Y199	3.75	No	Yes	5	3	6
140	R:R:S203	R:R:Y199	11.45	No	Yes	0	5	6
141	R:R:F290	R:R:S204	5.28	Yes	No	0	7	5
142	R:R:N293	R:R:S204	4.47	No	No	0	5	5
143	R:R:I294	R:R:S204	6.19	No	No	0	6	5
144	R:R:F208	R:R:Y209	12.38	Yes	No	0	8	5
145	R:R:F208	R:R:L212	9.74	Yes	No	0	8	7
146	R:R:F208	R:R:F282	5.36	Yes	No	0	8	9
147	R:R:F208	R:R:L287	6.09	Yes	Yes	0	8	6
148	R:R:F208	R:R:F290	20.36	Yes	Yes	0	8	7
149	R:R:I291	R:R:Y209	3.63	No	No	0	6	5
150	R:R:I294	R:R:Y209	4.84	No	No	0	6	5
151	R:R:F282	R:R:M215	6.22	No	No	0	9	8
152	R:R:V222	R:R:Y219	3.79	No	Yes	0	8	9
153	R:R:I278	R:R:Y219	3.63	Yes	Yes	0	8	9
154	R:R:M279	R:R:Y219	7.18	No	Yes	0	8	9
155	R:R:E225	R:R:R221	4.65	Yes	No	6	5	5
156	R:R:F223	R:R:L272	9.74	Yes	No	0	6	7
157	R:R:F223	R:R:L275	3.65	Yes	No	0	6	8
158	R:R:E225	R:R:R228	6.98	Yes	No	0	5	4
159	R:R:E225	R:R:K232	9.45	Yes	No	0	5	4
160	R:R:C226	R:R:Q229	4.58	No	No	0	8	7
161	R:R:Q231	R:R:R228	8.18	No	No	0	5	4
162	R:R:L230	R:R:Q231	3.99	No	No	0	5	5
163	R:R:E268	R:R:H269	6.15	No	No	0	7	5
164	R:R:K270	R:R:K273	5.75	No	No	0	7	7
165	R:R:I278	R:R:I325	5.89	Yes	No	2	8	8
166	R:R:I278	R:R:Y326	3.63	Yes	Yes	2	8	9
167	R:R:G280	R:R:T283	3.64	No	No	0	5	7
168	R:R:F321	R:R:T281	3.89	No	No	0	6	6
169	R:R:I325	R:R:T281	4.56	No	No	0	8	6
170	R:R:L287	R:R:T283	4.42	Yes	No	0	6	7
171	R:R:F290	R:R:W286	8.02	Yes	Yes	0	7	8
172	R:R:G315	R:R:W286	9.85	No	Yes	0	7	8
173	R:R:N318	R:R:W286	6.78	No	Yes	0	9	8
174	R:R:I291	R:R:L287	4.28	No	Yes	0	6	6
175	R:R:F289	R:R:F290	13.93	Yes	Yes	1	6	7
176	R:R:F289	R:R:Y308	9.28	Yes	No	0	6	5
177	R:R:F289	R:R:N312	12.08	Yes	No	1	6	5
178	R:R:I303	R:R:V292	6.14	Yes	No	0	3	5
179	R:R:L311	R:R:V292	4.47	No	No	0	5	5
180	R:R:N293	R:R:Y308	9.3	No	No	0	5	5
181	R:R:H296	R:R:I303	5.3	No	Yes	0	3	3
182	R:R:L302	R:R:Q299	7.99	No	No	0	1	2
183	R:R:E306	R:R:K305	4.05	No	No	0	2	2
184	R:R:N312	R:R:Y316	6.98	No	Yes	1	5	6
185	R:R:W313	R:R:Y316	10.61	Yes	Yes	1	5	6
186	R:R:F321	R:R:V317	6.55	No	No	0	6	5
187	R:R:N318	R:R:N322	12.26	No	Yes	0	9	9
188	R:R:N322	R:R:Y326	5.81	Yes	Yes	2	9	9
189	R:R:I325	R:R:Y326	7.25	No	Yes	2	8	9
190	R:R:C327	R:R:F332	16.76	No	Yes	4	7	9
191	R:R:C327	R:R:F336	4.19	No	Yes	4	7	7
192	R:R:P330	R:R:S329	5.34	No	No	0	5	8
193	R:R:F332	R:R:S329	5.28	Yes	No	0	9	8
194	R:R:F332	R:R:F336	4.29	Yes	Yes	4	9	7
195	R:R:L342	R:R:Q337	3.99	No	No	0	8	4
196	R:R:L340	R:R:L342	5.54	No	No	0	6	8
197	R:R:G35	R:R:I38	3.53	No	No	0	5	5
198	R:R:G320	R:R:I47	3.53	No	No	0	7	8
199	R:R:P211	R:R:V210	3.53	No	No	0	8	5
200	R:R:I94	R:R:W313	3.52	No	Yes	0	5	5
201	R:R:C116	R:R:V81	3.42	No	No	0	7	7
202	R:R:A76	R:R:V54	3.39	No	No	0	9	9
203	R:R:I121	R:R:P211	3.39	No	No	0	7	8
204	R:R:L287	R:R:P288	3.28	Yes	No	0	6	9
205	R:R:L311	R:R:P288	3.28	No	No	0	5	9
206	R:R:C285	R:R:I314	3.27	No	No	0	9	7
207	R:R:A76	R:R:I55	3.25	No	No	0	9	7
208	R:R:V44	R:R:V87	3.21	No	Yes	0	6	7
209	R:R:S137	R:R:T136	3.2	No	Yes	0	6	7
210	R:R:T56	R:R:V52	3.17	No	No	0	5	3
211	R:R:C285	R:R:N318	3.15	No	No	0	9	9
212	R:R:A76	R:R:N51	3.13	No	Yes	0	9	9
213	R:R:A198	R:R:N196	3.13	No	No	0	4	4
214	R:R:R131	R:R:Y326	3.09	No	Yes	0	9	9
215	R:R:I298	R:R:V295	3.07	No	No	0	4	4
216	R:R:I303	R:R:V295	3.07	Yes	No	0	3	4
217	R:R:I58	R:R:T73	3.04	No	No	0	7	6
218	R:R:C190	R:R:E187	3.04	No	No	0	3	4
219	R:R:L45	R:R:S41	3	No	No	0	5	4
220	R:R:L144	R:R:S143	3	No	No	0	4	4
221	R:R:L212	R:R:V216	2.98	No	No	0	7	5
222	R:R:L275	R:R:V222	2.98	No	No	0	8	8
223	R:R:L311	R:R:V307	2.98	No	No	0	5	4
224	R:R:I201	R:R:I205	2.94	No	No	0	5	4
225	R:R:I201	R:R:I294	2.94	No	No	0	5	6
226	R:R:I277	R:R:I278	2.94	No	Yes	0	7	8
227	R:R:D331	R:R:S329	2.94	No	No	0	7	8
228	R:R:Q170	R:R:S111	2.89	No	No	0	4	6
229	R:R:E122	R:R:S161	2.87	No	No	0	5	8
230	R:R:Q197	R:R:V297	2.87	No	No	0	2	5
231	R:R:I159	R:R:L163	2.85	No	No	0	4	4
232	R:R:I303	R:R:L302	2.85	Yes	No	0	3	1
233	R:R:K60	R:R:L339	2.82	No	No	0	5	6
234	R:R:G90	R:R:W109	2.81	No	Yes	0	7	5
235	R:R:G102	R:R:W99	2.81	No	Yes	0	7	7
236	R:R:L339	R:R:L53	2.77	No	No	0	6	6
237	R:R:L340	R:R:L53	2.77	No	No	0	6	6
238	R:R:A57	R:R:F336	2.77	No	Yes	0	8	7
239	R:R:A150	R:R:F71	2.77	No	Yes	0	7	8
240	R:R:L163	R:R:L167	2.77	No	No	0	4	5
241	R:R:A271	R:R:F223	2.77	No	Yes	0	8	6
242	R:R:I201	R:R:Q197	2.74	No	No	0	5	2
243	R:R:A150	R:R:Y70	2.67	No	No	0	7	4
244	R:R:N183	R:R:Q179	2.64	No	No	0	3	3
245	R:R:R304	R:R:V307	2.62	No	No	0	4	4
246	R:R:A78	R:R:W158	2.59	No	No	0	8	9
247	R:R:V218	R:R:Y132	2.52	No	Yes	0	6	8
248	R:R:D300	R:R:H296	2.52	No	No	0	1	3
249	R:R:K147	R:R:R151	2.48	No	No	0	1	3
250	R:R:F223	R:R:K227	2.48	Yes	No	0	6	6
251	R:R:Q65	R:R:Y70	2.25	No	No	0	8	4
252	R:R:G83	R:R:P88	2.03	No	No	0	7	8
253	R:R:G162	R:R:S165	1.86	No	No	0	4	7
254	R:R:P138	R:R:S137	1.78	No	No	0	8	6
255	R:R:G37	R:R:M36	1.75	No	No	0	5	5
256	R:R:C125	R:R:V129	1.71	No	No	0	7	6
257	R:R:A200	R:R:V297	1.7	No	No	0	5	5
258	R:R:C77	R:R:T73	1.69	No	No	0	6	6
259	R:R:L167	R:R:P168	1.64	No	No	0	5	5
260	R:R:A85	R:R:I112	1.62	No	No	0	4	4
261	R:R:A176	R:R:I182	1.62	No	No	0	1	1
262	R:R:S220	R:R:V216	1.62	No	No	0	3	5
263	R:R:T96	R:R:T98	1.57	No	No	0	4	5
264	R:R:T100	R:R:T98	1.57	No	No	0	2	5
265	R:R:I38	R:R:V39	1.54	No	No	0	5	5
266	R:R:I278	R:R:T274	1.52	Yes	No	0	8	8
267	R:R:K273	R:R:T274	1.5	No	No	0	7	8
268	R:R:N196	R:R:T177	1.46	No	No	0	4	3
269	R:R:L95	R:R:M36	1.41	No	No	0	6	5
270	R:R:K140	R:R:L144	1.41	No	No	0	5	4
271	R:R:K149	R:R:L145	1.41	No	No	0	5	7
272	R:R:D300	R:R:N301	1.35	No	No	0	1	2
273	R:R:H269	R:R:K270	1.31	No	No	0	5	7
274	R:R:I334	R:R:R63	1.25	No	No	0	4	6
275	R:R:F49	R:R:L340	1.22	No	No	0	4	6
276	R:R:K147	R:R:Y70	1.19	No	No	0	1	4
277	R:R:N196	R:R:Y199	1.16	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.7775	12	1	0
2	R:R:N51	5.8125	4	0	9
3	R:R:F71	6.28167	6	3	8
4	R:R:L75	5.225	4	2	9
5	R:R:D79	7.334	5	2	9
6	R:R:L80	5.6825	4	7	7
7	R:R:M82	6.2575	4	1	7
8	R:R:V87	3.905	4	1	7
9	R:R:W99	7.39333	6	8	7
10	R:R:W109	6.685	4	0	5
11	R:R:Y132	6.5375	4	6	8
12	R:R:T136	4.7	4	6	7
13	R:R:F166	5.215	4	9	4
14	R:R:Y174	6.44	5	5	5
15	R:R:R175	7.41	4	5	2
16	R:R:Y199	5.376	5	5	6
17	R:R:F208	10.786	5	0	8
18	R:R:Y219	5.3175	4	0	9
19	R:R:F223	4.66	4	0	6
20	R:R:E225	6.3275	4	6	5
21	R:R:I278	3.522	5	2	8
22	R:R:W286	9.036	5	0	8
23	R:R:L287	4.5175	4	0	6
24	R:R:F289	10.82	4	1	6
25	R:R:F290	10.636	5	1	7
26	R:R:I303	4.34	4	0	3
27	R:R:W313	5.898	5	1	5
28	R:R:Y316	6.965	6	1	6
29	R:R:N322	7.708	5	2	9
30	R:R:Y326	5.832	5	2	9
31	R:R:F332	9.88333	6	4	9
32	R:R:F336	4.64	4	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D113	42.9249	20.47	Yes	No	1	0	7
2	R:R:D113	R:R:Y316	24.9478	8.05	No	Yes	1	7	6
3	R:R:W313	R:R:Y316	14.078	10.61	Yes	Yes	1	5	6
4	L:L:?1	R:R:N312	25.3047	11.71	Yes	No	1	0	5
5	R:R:N312	R:R:Y316	28.2737	6.98	No	Yes	1	5	6
6	R:R:D113	R:R:V86	17.9582	7.3	No	No	1	7	7
7	R:R:M82	R:R:V86	17.8025	6.09	Yes	No	1	7	7
8	R:R:M82	R:R:S319	54.8806	7.67	Yes	No	0	7	9
9	R:R:M82	R:R:Y316	41.4936	4.79	Yes	Yes	1	7	6
10	R:R:D79	R:R:S319	51.5092	11.78	Yes	No	0	9	9
11	R:R:D79	R:R:N51	84.9311	6.73	Yes	Yes	0	9	9
12	R:R:L80	R:R:N51	12.3163	6.87	Yes	Yes	0	7	9
13	L:L:?1	R:R:V117	44.5233	5.86	Yes	No	0	0	6
14	R:R:V117	R:R:W286	44.4284	13.48	No	Yes	0	6	8
15	R:R:N318	R:R:W286	100	6.78	No	Yes	0	9	8
16	R:R:N318	R:R:N322	98.0068	12.26	No	Yes	0	9	9
17	R:R:D79	R:R:N322	45.6889	6.73	Yes	Yes	2	9	9
18	L:L:?1	R:R:F290	61.4906	5.59	Yes	Yes	1	0	7
19	R:R:F290	R:R:W286	60.3022	8.02	Yes	Yes	0	7	8
20	R:R:A76	R:R:N51	67.0716	3.13	No	Yes	0	9	9
21	R:R:A76	R:R:V54	62.5308	3.39	No	No	0	9	9
22	R:R:C327	R:R:V54	60.2301	5.12	No	No	0	7	9
23	R:R:C327	R:R:F336	27.5561	4.19	No	Yes	4	7	7
24	R:R:F336	R:R:L53	23.6797	7.31	Yes	No	0	7	6
25	R:R:C327	R:R:F332	30.6921	16.76	No	Yes	4	7	9
26	R:R:L339	R:R:L53	11.5646	2.77	No	No	0	6	6
27	R:R:F332	R:R:S329	12.3163	5.28	Yes	No	0	9	8
28	R:R:L75	R:R:N322	26.0526	6.87	Yes	Yes	2	9	9
29	R:R:L75	R:R:T123	34.6179	4.42	Yes	No	0	9	8
30	R:R:S74	R:R:T123	33.2283	6.4	No	No	0	9	8
31	R:R:I154	R:R:S74	27.5941	7.74	No	No	0	8	9
32	R:R:F71	R:R:I154	26.1665	7.54	Yes	No	0	8	8
33	L:L:?1	R:R:W109	21.4739	4.48	Yes	Yes	0	0	5
34	R:R:W109	R:R:W99	16.0143	8.43	Yes	Yes	0	5	7
35	L:L:?1	R:R:F193	54.2921	19.97	Yes	No	0	0	4
36	R:R:F193	R:R:T195	52.8722	11.67	No	No	0	4	3
37	R:R:T195	R:R:Y174	51.3877	4.99	No	Yes	5	3	5
38	R:R:R175	R:R:Y174	25.3275	9.26	Yes	Yes	5	2	5
39	R:R:H172	R:R:R175	14.4539	9.03	No	Yes	0	4	2
40	R:R:E107	R:R:H172	10.7293	7.39	No	No	0	5	4
41	L:L:?1	R:R:S203	70.333	9.85	Yes	No	0	0	5
42	R:R:S203	R:R:Y199	68.8523	11.45	No	Yes	0	5	6
43	R:R:Y174	R:R:Y199	51.9534	4.96	Yes	Yes	5	5	6
44	R:R:I169	R:R:Y174	40.0167	6.04	No	Yes	0	5	5
45	R:R:I169	R:R:S111	33.0536	7.74	No	No	0	5	6
46	R:R:F166	R:R:S111	26.0678	7.93	Yes	No	0	4	6
47	R:R:F166	R:R:L115	11.2153	4.87	Yes	No	0	4	5
48	L:L:?1	R:R:S207	16.2762	4.92	Yes	No	0	0	5
49	R:R:S207	R:R:T118	14.2678	4.8	No	No	0	5	6
50	R:R:F208	R:R:F290	26.0109	20.36	Yes	Yes	0	8	7
51	R:R:I121	R:R:W286	10.0611	7.05	No	Yes	0	7	8
52	R:R:N322	R:R:Y326	53.6277	5.81	Yes	Yes	2	9	9
53	R:R:I278	R:R:Y326	49.1325	3.63	Yes	Yes	2	8	9
54	R:R:I278	R:R:Y219	41.224	3.63	Yes	Yes	0	8	9
55	R:R:V222	R:R:Y219	37.5299	3.79	No	Yes	0	8	9
56	R:R:V222	R:R:Y132	29.5114	3.79	No	Yes	0	8	8
57	R:R:T136	R:R:Y132	17.1001	7.49	Yes	Yes	6	7	8
58	R:R:Y174	R:R:Y185	35.791	6.95	Yes	No	5	5	1
59	R:R:F194	R:R:Y185	32.4538	6.19	No	No	0	1	1
60	R:R:D192	R:R:F194	25.3199	8.36	No	No	0	3	1
61	R:R:C184	R:R:D192	14.9398	4.67	No	No	0	1	3
62	R:R:C184	R:R:C190	11.2153	7.28	No	No	0	1	3
63	R:R:F208	R:R:L287	19.6439	6.09	Yes	Yes	0	8	6
64	R:R:L287	R:R:P288	15.5928	3.28	Yes	No	0	6	9
65	R:R:L311	R:R:P288	14.4387	3.28	No	No	0	5	9
66	R:R:L311	R:R:V292	10.9306	4.47	No	No	0	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W109	4.48	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:D113	20.47	1	Yes	No	0	7	0	1
L:L:?1	R:R:V114	14.65	1	Yes	No	0	5	0	1
L:L:?1	R:R:V117	5.86	1	Yes	No	0	6	0	1
L:L:?1	R:R:F193	19.97	1	Yes	No	0	4	0	1
L:L:?1	R:R:S203	9.85	1	Yes	No	0	5	0	1
L:L:?1	R:R:S207	4.92	1	Yes	No	0	5	0	1
L:L:?1	R:R:F289	7.99	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F290	5.59	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N293	8.1	1	Yes	No	0	5	0	1
L:L:?1	R:R:I309	3.74	1	Yes	No	0	3	0	1
L:L:?1	R:R:N312	11.71	1	Yes	No	0	5	0	1
R:R:D113	R:R:V86	7.3	1	No	No	7	7	1	2
R:R:V86	R:R:Y316	6.31	1	No	Yes	7	6	2	2
R:R:F89	R:R:W109	11.02	0	No	Yes	5	5	2	1
R:R:W109	R:R:W99	8.43	0	Yes	Yes	5	7	1	2
R:R:D113	R:R:Y316	8.05	1	No	Yes	7	6	1	2
R:R:V117	R:R:W286	13.48	0	No	Yes	6	8	1	2
R:R:S207	R:R:T118	4.8	0	No	No	5	6	1	2
R:R:F193	R:R:T195	11.67	0	No	No	4	3	1	2
R:R:T195	R:R:Y199	3.75	5	No	Yes	3	6	2	2
R:R:S203	R:R:Y199	11.45	0	No	Yes	5	6	1	2
R:R:F290	R:R:S204	5.28	1	Yes	No	7	5	1	2
R:R:N293	R:R:S204	4.47	0	No	No	5	5	1	2
R:R:F208	R:R:F290	20.36	0	Yes	Yes	8	7	2	1
R:R:F290	R:R:W286	8.02	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:F290	13.93	1	Yes	Yes	6	7	1	1
R:R:F289	R:R:Y308	9.28	1	Yes	No	6	5	1	2
R:R:F289	R:R:N312	12.08	1	Yes	No	6	5	1	1
R:R:N293	R:R:Y308	9.3	0	No	No	5	5	1	2
R:R:N312	R:R:Y316	6.98	1	No	Yes	5	6	1	2
R:R:G90	R:R:W109	2.81	0	No	Yes	7	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6E67_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	256
Number of Links	277
Number of Hubs	32
Number of Links mediated by Hubs	129
Number of Communities	9
Number of Nodes involved in Communities	46
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	63923
Length Of Smallest Path	3
Average Path Length	13.4886
Length of Longest Path	25
Minimum Path Strength	1.31
Average Path Strength	7.22275
Maximum Path Strength	20.22
Minimum Path Correlation	0.7
Average Path Correlation	0.924426
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.1194
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.7139
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • amide binding • amyloid-beta binding • binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • metal ion binding • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process
Gene Ontology	Biological Process	• defense response to bacterium • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • multicellular organismal process • response to nutrient levels • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • energy homeostasis • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • regulation of biological process • bone mineralization • animal organ development • biological regulation • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • cellular component organization • autophagosome maturation • cellular component organization or biogenesis • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • other organism part • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • protein-containing complex • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • cell periphery • apical part of cell • plasma membrane • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P0G
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P0G
Name	8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one
Synonyms
Identifier
Formula	C21 H26 N2 O4
Molecular Weight	370.442
SMILES
PubChem	49837874
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	1
Total Bonds	55
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>6E67_nogp_Chain_R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L T K T W T F G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S F L P I Q M H W Y R A T H Q E A I N C Y A E E T C C D F F T N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E C K R Q L Q K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q D N L I R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E L L C L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	doi.org/10.1126/science.aaw8981
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	GTPL11074	-	3.1	2020-03-25	doi.org/10.1038/s41589-020-0549-2
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	Cmpd-15	-	2.7	2017-08-16	doi.org/10.1038/nature23652
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	doi.org/10.1016/j.str.2008.05.001
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	3.16	2010-08-11	doi.org/10.1021/ja105108q
	2R4R	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	2R4S	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	doi.org/10.1038/nature08650
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	doi.org/10.1038/nature09648
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.5	2011-01-12	doi.org/10.1038/nature09665
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	doi.org/10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	doi.org/10.1038/nature10361
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	doi.org/10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.1	2013-09-25	doi.org/10.1038/nature12572
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	L-Epinephrine	-	-	3.2	2013-09-25	doi.org/10.1038/nature12572
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-07-13	doi.org/10.1038/nature18636
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-08-17	doi.org/10.1038/nprot.2017.057
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	doi.org/10.1038/s41589-018-0145-x
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Formoterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	35V	-	-	3.3	2014-07-23	doi.org/10.1073/pnas.1410415111
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Noradrenaline	-	-	3.49	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHV	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.95	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.5	2024-11-13	doi.org/10.1073/pnas.2414544121
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carvedilol	-	-	2.5	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	S-Propranolol	-	-	2.9	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	doi.org/10.1107/S2052252519013137
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.48	2016-01-13	doi.org/10.1107/S2059798315021683
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.8	2016-01-13	doi.org/10.1107/S2059798315021683
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.99	2012-10-24	doi.org/10.1371/journal.pone.0046039
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971

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