psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D113	11.83	Yes	Yes	1	0	7
2	L:L:?1	R:R:V117	11.54	Yes	No	1	0	6
3	L:L:?1	R:R:F193	12.97	Yes	No	0	0	4
4	L:L:?1	R:R:S203	11.63	Yes	No	0	0	5
5	L:L:?1	R:R:S207	5.82	Yes	No	1	0	5
6	L:L:?1	R:R:F289	10.61	Yes	Yes	1	0	6
7	L:L:?1	R:R:F290	8.26	Yes	Yes	1	0	7
8	L:L:?1	R:R:N293	3.99	Yes	No	0	0	5
9	L:L:?1	R:R:N312	10.64	Yes	No	1	0	5
10	R:R:M36	R:R:W32	15.12	Yes	No	0	5	3
11	R:R:M36	R:R:V33	3.04	Yes	No	4	5	4
12	R:R:L95	R:R:V33	2.98	No	No	4	6	4
13	R:R:G35	R:R:V34	3.68	No	No	0	5	5
14	R:R:L95	R:R:M36	2.83	No	Yes	4	6	5
15	R:R:A91	R:R:M40	6.44	No	No	2	6	6
16	R:R:M40	R:R:W313	4.65	No	Yes	2	6	5
17	R:R:I43	R:R:I47	2.94	No	No	0	6	8
18	R:R:V44	R:R:V87	3.21	No	Yes	2	6	7
19	R:R:P88	R:R:V44	3.53	No	No	2	8	6
20	R:R:L80	R:R:V48	2.98	No	No	0	7	6
21	R:R:F49	R:R:L53	20.7	No	No	0	4	6
22	R:R:D79	R:R:N51	5.39	Yes	No	0	9	9
23	R:R:L80	R:R:N51	6.87	No	No	0	7	9
24	R:R:N51	R:R:P323	3.26	No	No	0	9	9
25	R:R:L80	R:R:V52	2.98	No	No	0	7	3
26	R:R:P323	R:R:V54	3.53	No	No	0	9	9
27	R:R:C327	R:R:V54	3.42	No	No	0	7	9
28	R:R:A76	R:R:I55	3.25	No	No	0	9	7
29	R:R:A57	R:R:F336	2.77	No	No	0	8	7
30	R:R:I58	R:R:N69	2.83	No	Yes	0	7	9
31	R:R:I58	R:R:T73	4.56	No	No	0	7	6
32	R:R:F61	R:R:K60	16.13	Yes	No	3	6	5
33	R:R:K60	R:R:L339	2.82	No	No	3	5	6
34	R:R:A335	R:R:F61	2.77	No	Yes	0	7	6
35	R:R:E338	R:R:F61	16.32	No	Yes	3	4	6
36	R:R:F61	R:R:L339	3.65	Yes	No	3	6	6
37	R:R:E62	R:R:R63	3.49	No	No	0	6	6
38	R:R:D331	R:R:R63	3.57	No	No	0	7	6
39	R:R:D331	R:R:L64	9.5	No	No	0	7	8
40	R:R:Q65	R:R:Y70	7.89	No	No	0	8	4
41	R:R:T66	R:R:T68	3.14	No	No	0	7	8
42	R:R:N69	R:R:T66	5.85	Yes	No	0	9	7
43	R:R:L145	R:R:V67	2.98	No	Yes	0	7	6
44	R:R:K147	R:R:V67	10.62	No	Yes	0	1	6
45	R:R:I72	R:R:N69	4.25	No	Yes	0	8	9
46	R:R:F71	R:R:V126	7.87	Yes	No	0	8	7
47	R:R:F71	R:R:I127	3.77	Yes	No	0	8	9
48	R:R:D130	R:R:F71	9.55	No	Yes	0	8	8
49	R:R:F71	R:R:I154	5.02	Yes	No	0	8	8
50	R:R:I154	R:R:S74	4.64	No	No	0	8	9
51	R:R:S74	R:R:W158	6.18	No	No	0	9	9
52	R:R:D79	R:R:L75	4.07	Yes	Yes	5	9	9
53	R:R:L75	R:R:T123	5.9	Yes	No	0	9	8
54	R:R:L124	R:R:L75	2.77	No	Yes	0	8	9
55	R:R:L75	R:R:N322	5.49	Yes	No	5	9	9
56	R:R:A78	R:R:W158	2.59	No	No	0	8	9
57	R:R:D79	R:R:S120	2.94	Yes	No	0	9	9
58	R:R:D79	R:R:S319	11.78	Yes	No	0	9	9
59	R:R:D79	R:R:N322	6.73	Yes	No	5	9	9
60	R:R:C116	R:R:V81	3.42	No	No	0	7	7
61	R:R:G83	R:R:M82	3.49	No	Yes	0	7	7
62	R:R:M82	R:R:V86	4.56	Yes	No	0	7	7
63	R:R:C116	R:R:M82	4.86	No	Yes	0	7	7
64	R:R:M82	R:R:S319	3.07	Yes	No	0	7	9
65	R:R:G83	R:R:V87	3.68	No	Yes	0	7	7
66	R:R:V86	R:R:W109	6.13	No	Yes	0	7	5
67	R:R:D113	R:R:V86	7.3	Yes	No	0	7	7
68	R:R:P88	R:R:V87	3.53	No	Yes	2	8	7
69	R:R:V87	R:R:W313	3.68	Yes	Yes	2	7	5
70	R:R:F101	R:R:F89	3.22	Yes	No	0	5	5
71	R:R:F89	R:R:W109	3.01	No	Yes	0	5	5
72	R:R:G90	R:R:W109	4.22	No	Yes	0	7	5
73	R:R:A91	R:R:W313	2.59	No	Yes	2	6	5
74	R:R:H93	R:R:W99	7.41	No	Yes	0	4	7
75	R:R:F101	R:R:W99	9.02	Yes	Yes	0	5	7
76	R:R:C106	R:R:W99	2.61	No	Yes	6	9	7
77	R:R:W109	R:R:W99	4.69	Yes	Yes	0	5	7
78	R:R:C191	R:R:W99	10.45	No	Yes	6	9	7
79	R:R:F101	R:R:T100	9.08	Yes	No	0	5	2
80	R:R:F101	R:R:W105	3.01	Yes	No	0	5	5
81	R:R:F104	R:R:W105	4.01	No	No	0	1	5
82	R:R:C106	R:R:C191	7.28	No	No	6	9	9
83	R:R:E107	R:R:Y174	5.61	No	No	0	5	5
84	R:R:E107	R:R:R175	5.82	No	No	0	5	2
85	R:R:F108	R:R:I112	6.28	No	No	7	5	4
86	R:R:F108	R:R:F166	6.43	No	Yes	7	5	4
87	R:R:F193	R:R:T110	2.59	No	No	0	4	4
88	R:R:F166	R:R:S111	9.25	Yes	No	0	4	6
89	R:R:I169	R:R:S111	6.19	No	No	0	5	6
90	R:R:F166	R:R:I112	3.77	Yes	No	7	4	4
91	R:R:D113	R:R:V117	2.92	Yes	No	1	7	6
92	R:R:D113	R:R:Y316	11.49	Yes	No	0	7	6
93	R:R:S165	R:R:V114	3.23	No	No	0	7	5
94	R:R:I169	R:R:V114	3.07	No	No	0	5	5
95	R:R:G162	R:R:L115	3.42	No	No	0	4	5
96	R:R:L115	R:R:S165	9.01	No	No	0	5	7
97	R:R:V117	R:R:W286	6.13	No	Yes	0	6	8
98	R:R:S161	R:R:T118	6.4	No	No	0	8	6
99	R:R:T118	R:R:T164	3.14	No	No	0	6	5
100	R:R:S207	R:R:T118	6.4	No	No	0	5	6
101	R:R:A119	R:R:W158	3.89	No	No	0	7	9
102	R:R:A119	R:R:S161	3.42	No	No	0	7	8
103	R:R:F282	R:R:I121	3.77	Yes	No	0	9	7
104	R:R:E122	R:R:V157	2.85	No	No	0	5	7
105	R:R:E122	R:R:S161	2.87	No	No	0	5	8
106	R:R:L124	R:R:Y326	5.86	No	No	0	8	9
107	R:R:C125	R:R:P211	3.77	No	No	0	7	8
108	R:R:C125	R:R:I214	4.91	No	No	0	7	6
109	R:R:I127	R:R:Y326	4.84	No	No	0	9	9
110	R:R:A128	R:R:Y219	5.34	No	Yes	0	8	9
111	R:R:F133	R:R:V129	3.93	Yes	No	0	5	6
112	R:R:D130	R:R:L145	5.43	No	No	0	8	7
113	R:R:F133	R:R:Y132	4.13	Yes	Yes	0	5	8
114	R:R:T136	R:R:Y132	13.73	No	Yes	0	7	8
115	R:R:V218	R:R:Y132	7.57	No	Yes	0	6	8
116	R:R:R221	R:R:Y132	5.14	Yes	Yes	0	5	8
117	R:R:A134	R:R:Y141	9.34	No	Yes	0	8	7
118	R:R:I135	R:R:V222	3.07	No	No	0	9	8
119	R:R:E225	R:R:I135	5.47	No	No	0	5	9
120	R:R:E225	R:R:T136	11.29	No	No	0	5	7
121	R:R:K140	R:R:L144	2.82	No	No	0	5	4
122	R:R:Q142	R:R:Y141	3.38	No	Yes	0	4	7
123	R:R:L145	R:R:Y141	4.69	No	Yes	0	7	7
124	R:R:K149	R:R:T146	3	No	No	0	5	8
125	R:R:K149	R:R:N148	11.19	No	No	0	5	4
126	R:R:L155	R:R:R151	3.64	No	No	0	3	3
127	R:R:M156	R:R:V152	4.56	No	No	0	4	4
128	R:R:I153	R:R:M156	4.37	No	No	0	6	4
129	R:R:L163	R:R:L167	2.77	No	No	0	4	5
130	R:R:F166	R:R:S165	5.28	Yes	No	0	4	7
131	R:R:F166	R:R:Q170	5.86	Yes	No	0	4	4
132	R:R:L167	R:R:P168	4.93	No	No	0	5	5
133	R:R:L167	R:R:W173	4.56	No	No	0	5	4
134	R:R:P168	R:R:Y199	5.56	No	Yes	0	5	6
135	R:R:M171	R:R:W173	15.12	No	No	0	4	4
136	R:R:H172	R:R:R175	21.44	No	No	0	4	2
137	R:R:Y174	R:R:Y185	3.97	No	No	0	5	1
138	R:R:Y174	R:R:Y199	4.96	No	Yes	0	5	6
139	R:R:R175	R:R:Y185	22.64	No	No	0	2	1
140	R:R:A176	R:R:H178	2.93	No	Yes	0	1	2
141	R:R:E180	R:R:H178	8.62	No	Yes	0	3	2
142	R:R:A181	R:R:H178	7.32	No	Yes	9	4	2
143	R:R:F194	R:R:H178	7.92	Yes	Yes	9	1	2
144	R:R:I182	R:R:Q179	6.86	No	No	0	1	3
145	R:R:A181	R:R:F194	4.16	No	Yes	9	4	1
146	R:R:E187	R:R:N183	5.26	No	No	0	7	3
147	R:R:C184	R:R:C190	7.28	No	No	0	1	3
148	R:R:C184	R:R:F194	2.79	No	Yes	0	1	1
149	R:R:E187	R:R:T189	4.23	No	No	0	7	4
150	R:R:D192	R:R:F194	3.58	No	Yes	0	3	1
151	R:R:F193	R:R:T195	5.19	No	No	0	4	3
152	R:R:T195	R:R:Y199	6.24	No	Yes	0	3	6
153	R:R:Q197	R:R:V297	5.73	No	No	0	2	5
154	R:R:S203	R:R:Y199	3.82	No	Yes	0	5	6
155	R:R:I201	R:R:I205	2.94	No	No	0	5	4
156	R:R:F290	R:R:S204	3.96	Yes	No	0	7	5
157	R:R:N293	R:R:S204	5.96	No	No	0	5	5
158	R:R:I294	R:R:S204	4.64	No	No	0	6	5
159	R:R:F290	R:R:S207	2.64	Yes	No	1	7	5
160	R:R:F208	R:R:Y209	8.25	Yes	No	0	8	5
161	R:R:F208	R:R:F282	6.43	Yes	Yes	1	8	9
162	R:R:F208	R:R:L287	3.65	Yes	No	0	8	6
163	R:R:F208	R:R:F290	21.43	Yes	Yes	1	8	7
164	R:R:P211	R:R:V210	5.3	No	No	0	8	5
165	R:R:M215	R:R:M279	4.33	No	No	0	8	8
166	R:R:F282	R:R:M215	3.73	Yes	No	0	9	8
167	R:R:F217	R:R:R221	5.34	No	Yes	8	4	5
168	R:R:L275	R:R:Y219	4.69	No	Yes	0	8	9
169	R:R:I278	R:R:Y219	3.63	No	Yes	0	8	9
170	R:R:M279	R:R:Y219	4.79	No	Yes	0	8	9
171	R:R:E225	R:R:R221	3.49	No	Yes	0	5	5
172	R:R:F223	R:R:L275	3.65	No	No	0	6	8
173	R:R:K227	R:R:Q231	2.71	No	No	0	6	5
174	R:R:D234	R:R:L230	4.07	No	No	10	4	5
175	R:R:E268	R:R:L230	13.25	No	No	10	7	5
176	R:R:D234	R:R:E268	2.6	No	No	10	4	7
177	R:R:E237	R:R:S236	4.31	No	No	0	3	4
178	R:R:E237	R:R:H241	17.23	No	No	0	3	3
179	R:R:F321	R:R:T281	2.59	No	No	0	6	6
180	R:R:I325	R:R:T281	4.56	No	No	0	8	6
181	R:R:F282	R:R:T283	2.59	Yes	No	0	9	7
182	R:R:F282	R:R:W286	4.01	Yes	Yes	0	9	8
183	R:R:L287	R:R:T283	2.95	No	No	0	6	7
184	R:R:C285	R:R:N318	11.02	No	No	0	9	9
185	R:R:F290	R:R:W286	4.01	Yes	Yes	0	7	8
186	R:R:G315	R:R:W286	8.44	No	Yes	0	7	8
187	R:R:N318	R:R:W286	7.91	No	Yes	0	9	8
188	R:R:L287	R:R:P288	4.93	No	No	0	6	9
189	R:R:L311	R:R:P288	3.28	No	No	0	5	9
190	R:R:F289	R:R:F290	4.29	Yes	Yes	1	6	7
191	R:R:F289	R:R:Y308	8.25	Yes	No	0	6	5
192	R:R:F289	R:R:N312	7.25	Yes	No	1	6	5
193	R:R:L311	R:R:V292	2.98	No	No	0	5	5
194	R:R:N293	R:R:Y308	6.98	No	No	0	5	5
195	R:R:I303	R:R:V295	3.07	No	No	0	3	4
196	R:R:H296	R:R:V297	6.92	No	No	0	3	5
197	R:R:H296	R:R:I303	3.98	No	No	0	3	3
198	R:R:H296	R:R:Y308	6.53	No	No	0	3	5
199	R:R:I298	R:R:Q299	6.86	No	No	0	4	2
200	R:R:L302	R:R:Q299	6.65	No	No	0	1	2
201	R:R:D300	R:R:N301	5.39	No	No	0	1	2
202	R:R:N301	R:R:R304	6.03	No	No	0	2	4
203	R:R:I303	R:R:V307	3.07	No	No	0	3	4
204	R:R:E306	R:R:K305	9.45	No	No	0	2	2
205	R:R:L311	R:R:V307	2.98	No	No	0	5	4
206	R:R:N312	R:R:Y316	15.12	No	No	0	5	6
207	R:R:W313	R:R:Y316	5.79	Yes	No	0	5	6
208	R:R:F321	R:R:V317	2.62	No	No	0	6	5
209	R:R:I325	R:R:Y326	7.25	No	No	0	8	9
210	R:R:C327	R:R:F332	6.98	No	Yes	0	7	9
211	R:R:P330	R:R:S329	3.56	No	No	0	5	8
212	R:R:F332	R:R:S329	6.61	Yes	No	0	9	8
213	R:R:F332	R:R:F336	3.22	Yes	No	0	9	7
214	R:R:I334	R:R:Q337	5.49	No	No	3	4	4
215	R:R:E338	R:R:I334	5.47	No	No	3	4	4
216	R:R:E338	R:R:Q337	5.1	No	No	3	4	4
217	R:R:V67	R:R:Y70	2.52	Yes	No	0	6	4
218	R:R:D192	R:R:H93	2.52	No	No	0	3	4
219	R:R:V114	R:R:Y199	2.52	No	Yes	0	5	6
220	R:R:I127	R:R:R131	2.51	No	No	0	9	9
221	R:R:F49	R:R:L340	2.44	No	No	0	4	6
222	R:R:F332	R:R:L64	2.44	Yes	No	0	9	8
223	R:R:F133	R:R:L144	2.44	Yes	No	0	5	4
224	R:R:F208	R:R:L212	2.44	Yes	No	1	8	7
225	R:R:F282	R:R:L212	2.44	Yes	No	1	9	7
226	R:R:F332	R:R:N69	2.42	Yes	Yes	0	9	9
227	R:R:I291	R:R:Y209	2.42	No	No	0	6	5
228	R:R:I309	R:R:W313	2.35	No	Yes	0	3	5
229	R:R:E306	R:R:R304	2.33	No	No	0	2	4
230	R:R:F240	R:R:R239	2.14	No	No	0	4	4
231	R:R:F133	R:R:Y141	2.06	Yes	Yes	0	5	7
232	R:R:G50	R:R:P323	2.03	No	No	0	8	9
233	R:R:G280	R:R:T283	1.82	No	No	0	5	7
234	R:R:A335	R:R:A57	1.79	No	No	0	7	8
235	R:R:P138	R:R:S137	1.78	No	No	0	8	6
236	R:R:G35	R:R:I38	1.76	No	No	0	5	5
237	R:R:G83	R:R:I47	1.76	No	No	0	7	8
238	R:R:G320	R:R:I47	1.76	No	No	0	7	8
239	R:R:G37	R:R:M36	1.75	No	Yes	0	5	5
240	R:R:G37	R:R:M40	1.75	No	No	0	5	6
241	R:R:G50	R:R:L53	1.71	No	No	0	8	6
242	R:R:A150	R:R:V67	1.7	No	Yes	0	7	6
243	R:R:A200	R:R:V297	1.7	No	No	0	5	5
244	R:R:C77	R:R:T73	1.69	No	No	0	6	6
245	R:R:I121	R:R:P211	1.69	No	No	0	7	8
246	R:R:C77	R:R:I55	1.64	No	No	0	6	7
247	R:R:A85	R:R:I112	1.62	No	No	0	4	4
248	R:R:S137	R:R:T136	1.6	No	No	0	6	7
249	R:R:T56	R:R:V52	1.59	No	No	0	5	3
250	R:R:T164	R:R:V206	1.59	No	No	0	5	4
251	R:R:A46	R:R:L42	1.58	No	No	0	5	5
252	R:R:T100	R:R:T96	1.57	No	No	0	2	4
253	R:R:T100	R:R:T98	1.57	No	No	0	2	5
254	R:R:A198	R:R:N196	1.56	No	No	0	4	4
255	R:R:I43	R:R:V39	1.54	No	No	0	6	5
256	R:R:I153	R:R:V126	1.54	No	No	0	6	7
257	R:R:I153	R:R:V157	1.54	No	No	0	6	7
258	R:R:I205	R:R:V210	1.54	No	No	0	4	5
259	R:R:I214	R:R:V213	1.54	No	No	0	6	4
260	R:R:C190	R:R:E187	1.52	No	No	0	3	7
261	R:R:M279	R:R:V216	1.52	No	No	0	8	5
262	R:R:I278	R:R:T274	1.52	No	No	0	8	8
263	R:R:I277	R:R:T281	1.52	No	No	0	7	6
264	R:R:F101	R:R:G102	1.51	Yes	No	0	5	7
265	R:R:L45	R:R:V48	1.49	No	No	0	5	6
266	R:R:N148	R:R:V152	1.48	No	No	0	4	4
267	R:R:I309	R:R:I94	1.47	No	No	0	3	5
268	R:R:I294	R:R:I298	1.47	No	No	0	6	4
269	R:R:D29	R:R:V31	1.46	No	No	0	5	2
270	R:R:N196	R:R:T195	1.46	No	No	0	4	3
271	R:R:E122	R:R:V160	1.43	No	No	0	5	4
272	R:R:E237	R:R:I233	1.37	No	No	0	3	6
273	R:R:N183	R:R:Q179	1.32	No	No	0	3	3
274	R:R:F217	R:R:S220	1.32	No	No	8	4	3
275	R:R:R221	R:R:S220	1.32	Yes	No	8	5	3
276	R:R:E188	R:R:N103	1.31	No	No	0	3	2
277	R:R:H269	R:R:K273	1.31	No	No	0	5	7
278	R:R:I325	R:R:R328	1.25	No	No	0	8	7
279	R:R:E268	R:R:H269	1.23	No	No	0	7	5
280	R:R:Q224	R:R:R221	1.17	No	Yes	0	3	5
281	R:R:F240	R:R:H241	1.13	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.69889	9	1	0
2	R:R:M36	5.685	4	4	5
3	R:R:F61	9.7175	4	3	6
4	R:R:V67	4.455	4	0	6
5	R:R:N69	3.8375	4	0	9
6	R:R:F71	6.5525	4	0	8
7	R:R:L75	4.5575	4	5	9
8	R:R:D79	6.182	5	5	9
9	R:R:M82	3.995	4	0	7
10	R:R:V87	3.525	4	2	7
11	R:R:W99	6.836	5	6	7
12	R:R:F101	5.168	5	0	5
13	R:R:W109	4.5125	4	0	5
14	R:R:D113	8.385	4	1	7
15	R:R:Y132	7.6425	4	0	8
16	R:R:F133	3.14	4	0	5
17	R:R:Y141	4.8675	4	0	7
18	R:R:F166	6.118	5	7	4
19	R:R:H178	6.6975	4	9	2
20	R:R:F194	4.6125	4	9	1
21	R:R:Y199	4.62	5	0	6
22	R:R:F208	8.44	5	1	8
23	R:R:Y219	4.6125	4	0	9
24	R:R:R221	3.292	5	8	5
25	R:R:F282	3.82833	6	1	9
26	R:R:W286	6.1	5	0	8
27	R:R:F289	7.6	4	1	6
28	R:R:F290	7.43167	6	1	7
29	R:R:W313	3.812	5	2	5
30	R:R:F332	4.334	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D113	75.5351	11.83	Yes	Yes	1	0	7
2	R:R:D113	R:R:Y316	16.6388	11.49	Yes	No	0	7	6
3	R:R:W313	R:R:Y316	24.5819	5.79	Yes	No	0	5	6
4	R:R:M40	R:R:W313	16.4967	4.65	No	Yes	2	6	5
5	R:R:G37	R:R:M40	13.8294	1.75	No	No	0	5	6
6	R:R:G37	R:R:M36	11.0953	1.75	No	Yes	0	5	5
7	L:L:?1	R:R:N312	11.1288	10.64	Yes	No	1	0	5
8	R:R:N312	R:R:Y316	12.9933	15.12	No	No	0	5	6
9	R:R:D113	R:R:V86	92.4833	7.3	Yes	No	0	7	7
10	R:R:M82	R:R:V86	83.4114	4.56	Yes	No	0	7	7
11	R:R:G83	R:R:M82	20.5769	3.49	No	Yes	0	7	7
12	R:R:V87	R:R:W313	13.2107	3.68	Yes	Yes	2	7	5
13	R:R:M82	R:R:S319	87.9599	3.07	Yes	No	0	7	9
14	R:R:D79	R:R:S319	87.3746	11.78	Yes	No	0	9	9
15	R:R:D79	R:R:N51	70.8445	5.39	Yes	No	0	9	9
16	R:R:L80	R:R:N51	10.694	6.87	No	No	0	7	9
17	R:R:N51	R:R:P323	61.2625	3.26	No	No	0	9	9
18	R:R:P323	R:R:V54	52.8177	3.53	No	No	0	9	9
19	R:R:C327	R:R:V54	51.0786	3.42	No	No	0	7	9
20	R:R:C327	R:R:F332	49.3227	6.98	No	Yes	0	7	9
21	R:R:F332	R:R:N69	18.9548	2.42	Yes	Yes	0	9	9
22	R:R:I58	R:R:N69	10.694	2.83	No	Yes	0	7	9
23	R:R:F332	R:R:F336	18.9548	3.22	Yes	No	0	9	7
24	R:R:A57	R:R:F336	16.9147	2.77	No	No	0	8	7
25	R:R:A335	R:R:A57	14.8579	1.79	No	No	0	7	8
26	R:R:A335	R:R:F61	12.7843	2.77	No	Yes	0	7	6
27	L:L:?1	R:R:S207	51.9983	5.82	Yes	No	1	0	5
28	R:R:S207	R:R:T118	100	6.4	No	No	0	5	6
29	R:R:S161	R:R:T118	96.413	6.4	No	No	0	8	6
30	R:R:A119	R:R:S161	43.5786	3.42	No	No	0	7	8
31	R:R:A119	R:R:W158	42.2324	3.89	No	No	0	7	9
32	R:R:S74	R:R:W158	40.2926	6.18	No	No	0	9	9
33	R:R:I154	R:R:S74	39.4314	4.64	No	No	0	8	9
34	R:R:F71	R:R:I154	39.0134	5.02	Yes	No	0	8	8
35	R:R:D130	R:R:F71	93.587	9.55	No	Yes	0	8	8
36	R:R:D130	R:R:L145	90.5937	5.43	No	No	0	8	7
37	R:R:L145	R:R:V67	17.1321	2.98	No	Yes	0	7	6
38	R:R:E122	R:R:S161	52.1906	2.87	No	No	0	5	8
39	R:R:E122	R:R:V157	49.6488	2.85	No	No	0	5	7
40	R:R:I153	R:R:V157	48.7124	1.54	No	No	0	6	7
41	R:R:I153	R:R:V126	43.3445	1.54	No	No	0	6	7
42	R:R:F71	R:R:V126	42.8512	7.87	Yes	No	0	8	7
43	R:R:D79	R:R:L75	50.5853	4.07	Yes	Yes	5	9	9
44	R:R:L124	R:R:L75	48.6538	2.77	No	Yes	0	8	9
45	R:R:L124	R:R:Y326	47.4833	5.86	No	No	0	8	9
46	R:R:I127	R:R:Y326	39.1137	4.84	No	No	0	9	9
47	R:R:F71	R:R:I127	40.9365	3.77	Yes	No	0	8	9
48	R:R:V86	R:R:W109	64.2391	6.13	No	Yes	0	7	5
49	R:R:F89	R:R:W109	15.3846	3.01	No	Yes	0	5	5
50	R:R:F101	R:R:F89	13.5368	3.22	Yes	No	0	5	5
51	R:R:W109	R:R:W99	45.8863	4.69	Yes	Yes	0	5	7
52	R:R:F101	R:R:W99	14.4732	9.02	Yes	Yes	0	5	7
53	R:R:H93	R:R:W99	28.0853	7.41	No	Yes	0	4	7
54	R:R:F101	R:R:T100	11.9816	9.08	Yes	No	0	5	2
55	L:L:?1	R:R:S203	66.5468	11.63	Yes	No	0	0	5
56	R:R:S203	R:R:Y199	64.1973	3.82	No	Yes	0	5	6
57	R:R:Y174	R:R:Y199	19.8746	4.96	No	Yes	0	5	6
58	R:R:V114	R:R:Y199	31.0702	2.52	No	Yes	0	5	6
59	R:R:S165	R:R:V114	22.7592	3.23	No	No	0	7	5
60	R:R:F166	R:R:S165	14.3562	5.28	Yes	No	0	4	7
61	R:R:V117	R:R:W286	30.3261	6.13	No	Yes	0	6	8
62	R:R:F282	R:R:W286	48.7709	4.01	Yes	Yes	0	9	8
63	L:L:?1	R:R:F290	30.8696	8.26	Yes	Yes	1	0	7
64	R:R:F290	R:R:W286	26.9482	4.01	Yes	Yes	0	7	8
65	R:R:F282	R:R:I121	29.8244	3.77	Yes	No	0	9	7
66	R:R:F208	R:R:F290	43.2107	21.43	Yes	Yes	1	8	7
67	R:R:F208	R:R:F282	23.9883	6.43	Yes	Yes	1	8	9
68	R:R:I121	R:R:P211	26.1538	1.69	No	No	0	7	8
69	R:R:C125	R:R:P211	11.3043	3.77	No	No	0	7	8
70	R:R:F282	R:R:M215	33.4783	3.73	Yes	No	0	9	8
71	R:R:M215	R:R:M279	29.8244	4.33	No	No	0	8	8
72	R:R:M279	R:R:Y219	22.4666	4.79	No	Yes	0	8	9
73	R:R:L145	R:R:Y141	72.2826	4.69	No	Yes	0	7	7
74	R:R:F133	R:R:Y141	62.9013	2.06	Yes	Yes	0	5	7
75	R:R:F133	R:R:Y132	50.1589	4.13	Yes	Yes	0	5	8
76	R:R:T136	R:R:Y132	20.2592	13.73	No	Yes	0	7	8
77	R:R:R221	R:R:Y132	23.6204	5.14	Yes	Yes	0	5	8
78	R:R:E225	R:R:T136	10.2508	11.29	No	No	0	5	7
79	R:R:E225	R:R:I135	13.5702	5.47	No	No	0	5	9
80	R:R:E225	R:R:R221	10.2759	3.49	No	Yes	0	5	5
81	R:R:I153	R:R:M156	12.6171	4.37	No	No	0	6	4
82	R:R:M156	R:R:V152	10.1254	4.56	No	No	0	4	4
83	R:R:P168	R:R:Y199	14.4147	5.56	No	Yes	0	5	6
84	R:R:L167	R:R:P168	11.5635	4.93	No	No	0	5	5
85	R:R:D192	R:R:H93	26.1873	2.52	No	No	0	3	4
86	R:R:D192	R:R:F194	24.2726	3.58	No	Yes	0	3	1
87	R:R:C184	R:R:F194	14.4482	2.79	No	Yes	0	1	1
88	R:R:C184	R:R:C190	12.4331	7.28	No	No	0	1	3
89	R:R:C190	R:R:E187	10.4013	1.52	No	No	0	3	7
90	L:L:?1	R:R:F193	13.1605	12.97	Yes	No	0	0	4
91	L:L:?1	R:R:F289	16.0201	10.61	Yes	Yes	1	0	6
92	R:R:F289	R:R:Y308	24.5819	8.25	Yes	No	0	6	5
93	R:R:H296	R:R:Y308	34.4398	6.53	No	No	0	3	5
94	R:R:H296	R:R:V297	15.092	6.92	No	No	0	3	5
95	L:L:?1	R:R:N293	23.311	3.99	Yes	No	0	0	5
96	R:R:N293	R:R:Y308	14.6488	6.98	No	No	0	5	5
97	R:R:P211	R:R:V210	11.3043	5.3	No	No	0	8	5
98	R:R:F290	R:R:S204	13.5201	3.96	Yes	No	0	7	5
99	R:R:I294	R:R:S204	16.0368	4.64	No	No	0	6	5
100	R:R:F208	R:R:L287	13.4866	3.65	Yes	No	0	8	6
101	R:R:I325	R:R:Y326	12.9348	7.25	No	No	0	8	9
102	R:R:L287	R:R:P288	10.0585	4.93	No	No	0	6	9
103	R:R:H296	R:R:I303	14.9415	3.98	No	No	0	3	3
104	R:R:I294	R:R:I298	12.0569	1.47	No	No	0	6	4
105	R:R:D113	R:R:V117	24.3227	2.92	Yes	No	1	7	6
106	R:R:F289	R:R:F290	11.9064	4.29	Yes	Yes	1	6	7
107	R:R:F290	R:R:S207	49.1388	2.64	Yes	No	1	7	5
108	R:R:G83	R:R:V87	11.3796	3.68	No	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D113	11.83	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V117	11.54	1	Yes	No	0	6	0	1
L:L:?1	R:R:F193	12.97	1	Yes	No	0	4	0	1
L:L:?1	R:R:S203	11.63	1	Yes	No	0	5	0	1
L:L:?1	R:R:S207	5.82	1	Yes	No	0	5	0	1
L:L:?1	R:R:F289	10.61	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F290	8.26	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N293	3.99	1	Yes	No	0	5	0	1
L:L:?1	R:R:N312	10.64	1	Yes	No	0	5	0	1
R:R:D113	R:R:V86	7.3	1	Yes	No	7	7	1	2
R:R:F193	R:R:T110	2.59	0	No	No	4	4	1	2
R:R:D113	R:R:V117	2.92	1	Yes	No	7	6	1	1
R:R:D113	R:R:Y316	11.49	1	Yes	No	7	6	1	2
R:R:V117	R:R:W286	6.13	1	No	Yes	6	8	1	2
R:R:S207	R:R:T118	6.4	1	No	No	5	6	1	2
R:R:F193	R:R:T195	5.19	0	No	No	4	3	1	2
R:R:T195	R:R:Y199	6.24	0	No	Yes	3	6	2	2
R:R:S203	R:R:Y199	3.82	0	No	Yes	5	6	1	2
R:R:F290	R:R:S204	3.96	1	Yes	No	7	5	1	2
R:R:N293	R:R:S204	5.96	0	No	No	5	5	1	2
R:R:F290	R:R:S207	2.64	1	Yes	No	7	5	1	1
R:R:F208	R:R:F290	21.43	1	Yes	Yes	8	7	2	1
R:R:F290	R:R:W286	4.01	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:F290	4.29	1	Yes	Yes	6	7	1	1
R:R:F289	R:R:Y308	8.25	1	Yes	No	6	5	1	2
R:R:F289	R:R:N312	7.25	1	Yes	No	6	5	1	1
R:R:N293	R:R:Y308	6.98	0	No	No	5	5	1	2
R:R:N312	R:R:Y316	15.12	1	No	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8UNS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.59
Number of Linked Nodes	260
Number of Links	281
Number of Hubs	30
Number of Links mediated by Hubs	122
Number of Communities	10
Number of Nodes involved in Communities	43
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	109
Number Of Links MetaPath	108
Number of Shortest Paths	40992
Length Of Smallest Path	3
Average Path Length	13.2116
Length of Longest Path	29
Minimum Path Strength	1.245
Average Path Strength	5.54764
Maximum Path Strength	22.04
Minimum Path Correlation	0.7
Average Path Correlation	0.977373
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	9.09091
Average % Of Corr. Nodes	81.5113
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.1722
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • amide binding • amyloid-beta binding • peptide binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • response to nutrient levels • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • positive regulation of biomineral tissue development • ossification • biomineral tissue development • regulation of multicellular organismal process • regulation of multicellular organismal development • bone mineralization • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • cellular component organization • autophagosome maturation • cellular component organization or biogenesis • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to amyloid-beta • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • receptor complex • intercellular bridge • endosome membrane • endosome • intracellular membraneless organelle • ciliary basal body • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • apical part of cell • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • early endosome • nucleus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	G1I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	G1I
Name	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier
Formula	C11 H15 N O3
Molecular Weight	209.242
SMILES
PubChem	12353638
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	2
Total Bonds	31
Total Aromatic Bonds	6


Code	GTP
PDB Residues	O:O:?1
Environment Details	Open EMBL-EBI Page
Code	GTP
Name	Guanosine-5'-Triphosphate
Synonyms	Guanosine-5'-Triphosphate
Identifier
Formula	C10 H16 N5 O14 P3
Molecular Weight	523.18
SMILES
PubChem	135398633
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	4
Total Bonds	50
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>8UNS_nogp_Chain_R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L T K T W T F G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S F L P I Q M H W Y R A T H Q E A I N C Y A E E T C C D F F T N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E G R F H E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q D N L I R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E L L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	doi.org/10.1126/science.aaw8981
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	GTPL11074	-	3.1	2020-03-25	doi.org/10.1038/s41589-020-0549-2
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	Cmpd-15	-	2.7	2017-08-16	doi.org/10.1038/nature23652
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	doi.org/10.1016/j.str.2008.05.001
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	3.16	2010-08-11	doi.org/10.1021/ja105108q
	2R4R	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	2R4S	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	doi.org/10.1038/nature08650
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	doi.org/10.1038/nature09648
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.5	2011-01-12	doi.org/10.1038/nature09665
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	doi.org/10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	doi.org/10.1038/nature10361
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	doi.org/10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.1	2013-09-25	doi.org/10.1038/nature12572
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	L-Epinephrine	-	-	3.2	2013-09-25	doi.org/10.1038/nature12572
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-07-13	doi.org/10.1038/nature18636
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-08-17	doi.org/10.1038/nprot.2017.057
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	doi.org/10.1038/s41589-018-0145-x
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Formoterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	35V	-	-	3.3	2014-07-23	doi.org/10.1073/pnas.1410415111
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Noradrenaline	-	-	3.49	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHV	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.95	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.5	2024-11-13	doi.org/10.1073/pnas.2414544121
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carvedilol	-	-	2.5	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	S-Propranolol	-	-	2.9	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	doi.org/10.1107/S2052252519013137
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.48	2016-01-13	doi.org/10.1107/S2059798315021683
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.8	2016-01-13	doi.org/10.1107/S2059798315021683
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.99	2012-10-24	doi.org/10.1371/journal.pone.0046039
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971

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