psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W109	6.72	Yes	No	0	0	5
2	L:L:?1	R:R:D113	17.8	Yes	No	1	0	7
3	L:L:?1	R:R:V114	7.82	Yes	No	0	0	5
4	L:L:?1	R:R:V117	6.84	Yes	No	0	0	6
5	L:L:?1	R:R:F193	23.96	Yes	Yes	1	0	4
6	L:L:?1	R:R:S203	9.85	Yes	No	0	0	5
7	L:L:?1	R:R:S207	3.94	Yes	No	0	0	5
8	L:L:?1	R:R:F289	7.19	Yes	Yes	1	0	6
9	L:L:?1	R:R:F290	8.79	Yes	Yes	1	0	7
10	L:L:?1	R:R:N293	11.71	Yes	No	1	0	5
11	L:L:?1	R:R:Y308	6.15	Yes	Yes	1	0	5
12	L:L:?1	R:R:N312	13.51	Yes	No	1	0	5
13	R:R:E30	R:R:W32	4.36	No	No	0	3	3
14	R:R:M36	R:R:W32	16.29	No	No	0	5	3
15	R:R:M36	R:R:M40	4.33	No	Yes	0	5	6
16	R:R:A91	R:R:M40	4.83	No	Yes	0	6	6
17	R:R:I94	R:R:M40	5.83	No	Yes	1	5	6
18	R:R:M40	R:R:W313	4.65	Yes	Yes	1	6	5
19	R:R:P88	R:R:V44	8.84	No	No	0	8	6
20	R:R:G83	R:R:I47	7.05	No	No	0	7	8
21	R:R:I47	R:R:V87	4.61	No	No	0	8	7
22	R:R:I47	R:R:S319	4.64	No	No	0	8	9
23	R:R:D79	R:R:N51	6.73	Yes	No	0	9	9
24	R:R:L80	R:R:N51	5.49	No	No	0	7	9
25	R:R:L80	R:R:V52	5.96	No	No	0	7	3
26	R:R:F336	R:R:L53	7.31	Yes	No	0	7	6
27	R:R:C327	R:R:V54	5.12	No	Yes	3	7	9
28	R:R:F336	R:R:V54	6.55	Yes	Yes	3	7	9
29	R:R:C77	R:R:I55	4.91	No	No	0	6	7
30	R:R:I58	R:R:L64	4.28	No	Yes	3	7	8
31	R:R:I58	R:R:T73	9.12	No	No	0	7	6
32	R:R:F332	R:R:I58	5.02	Yes	No	3	9	7
33	R:R:A335	R:R:F61	9.71	No	Yes	0	7	6
34	R:R:E338	R:R:F61	10.49	No	Yes	0	4	6
35	R:R:F61	R:R:L339	7.31	Yes	No	0	6	6
36	R:R:D331	R:R:R63	10.72	No	No	0	7	6
37	R:R:L64	R:R:N69	4.12	Yes	No	3	8	9
38	R:R:F332	R:R:L64	14.61	Yes	Yes	3	9	8
39	R:R:Q65	R:R:Y70	5.64	No	No	0	8	4
40	R:R:N69	R:R:T66	7.31	No	No	0	9	7
41	R:R:D130	R:R:T68	7.23	No	No	6	8	8
42	R:R:T68	R:R:Y141	6.24	No	Yes	6	8	7
43	R:R:F332	R:R:N69	12.08	Yes	No	3	9	9
44	R:R:F71	R:R:V126	7.87	Yes	No	0	8	7
45	R:R:A150	R:R:F71	4.16	No	Yes	0	7	8
46	R:R:F71	R:R:I153	7.54	Yes	No	0	8	6
47	R:R:F71	R:R:I154	7.54	Yes	No	0	8	8
48	R:R:I72	R:R:Y326	6.04	No	Yes	0	8	9
49	R:R:F332	R:R:I72	3.77	Yes	No	0	9	8
50	R:R:S74	R:R:T123	6.4	No	No	0	9	8
51	R:R:I154	R:R:S74	7.74	No	No	0	8	9
52	R:R:S74	R:R:W158	4.94	No	Yes	0	9	9
53	R:R:D79	R:R:L75	9.5	Yes	Yes	5	9	9
54	R:R:L75	R:R:T123	7.37	Yes	No	0	9	8
55	R:R:L124	R:R:L75	5.54	Yes	Yes	5	8	9
56	R:R:L75	R:R:N322	16.48	Yes	Yes	5	9	9
57	R:R:L75	R:R:Y326	4.69	Yes	Yes	5	9	9
58	R:R:A78	R:R:W158	3.89	No	Yes	0	8	9
59	R:R:D79	R:R:S120	5.89	Yes	No	0	9	9
60	R:R:D79	R:R:S319	8.83	Yes	No	0	9	9
61	R:R:D79	R:R:N322	10.77	Yes	Yes	5	9	9
62	R:R:C116	R:R:M82	6.48	No	No	0	7	7
63	R:R:M82	R:R:S319	9.2	No	No	0	7	9
64	R:R:D113	R:R:V86	7.3	No	No	1	7	7
65	R:R:V86	R:R:Y316	5.05	No	Yes	1	7	6
66	R:R:V87	R:R:Y316	5.05	No	Yes	0	7	6
67	R:R:F101	R:R:F89	20.36	Yes	No	2	5	5
68	R:R:F89	R:R:W105	4.01	No	No	2	5	5
69	R:R:F89	R:R:W109	9.02	No	No	0	5	5
70	R:R:H93	R:R:W99	12.7	No	Yes	0	4	7
71	R:R:I94	R:R:W313	5.87	No	Yes	1	5	5
72	R:R:F101	R:R:W99	31.07	Yes	Yes	2	5	7
73	R:R:C106	R:R:W99	5.22	No	Yes	2	9	7
74	R:R:C191	R:R:W99	11.75	No	Yes	2	9	7
75	R:R:F101	R:R:W105	5.01	Yes	No	2	5	5
76	R:R:E188	R:R:N103	15.77	No	No	0	3	2
77	R:R:F108	R:R:W105	13.03	No	No	0	5	5
78	R:R:C106	R:R:C191	7.28	No	No	2	9	9
79	R:R:E107	R:R:Q170	3.82	No	No	0	5	4
80	R:R:F166	R:R:S111	7.93	No	No	4	4	6
81	R:R:I169	R:R:S111	7.74	No	No	4	5	6
82	R:R:Q170	R:R:S111	5.78	No	No	4	4	6
83	R:R:D113	R:R:Y316	11.49	No	Yes	1	7	6
84	R:R:L115	R:R:W158	6.83	No	Yes	0	5	9
85	R:R:L115	R:R:S165	6.01	No	No	4	5	7
86	R:R:F166	R:R:L115	9.74	No	No	4	4	5
87	R:R:V117	R:R:W286	11.03	No	Yes	0	6	8
88	R:R:S161	R:R:T118	6.4	No	No	0	8	6
89	R:R:T118	R:R:T164	4.71	No	No	0	6	5
90	R:R:S207	R:R:T118	9.59	No	No	0	5	6
91	R:R:A119	R:R:W158	7.78	No	Yes	0	7	9
92	R:R:F282	R:R:I121	8.79	Yes	No	0	9	7
93	R:R:I121	R:R:W286	7.05	No	Yes	0	7	8
94	R:R:E122	R:R:S161	4.31	No	No	0	5	8
95	R:R:F282	R:R:L124	4.87	Yes	Yes	0	9	8
96	R:R:L124	R:R:N322	5.49	Yes	Yes	5	8	9
97	R:R:L124	R:R:Y326	8.21	Yes	Yes	5	8	9
98	R:R:C125	R:R:P211	3.77	No	No	0	7	8
99	R:R:C125	R:R:I214	6.55	No	No	0	7	6
100	R:R:C125	R:R:M215	4.86	No	No	0	7	8
101	R:R:I127	R:R:R131	6.26	No	No	0	9	9
102	R:R:I127	R:R:Y326	7.25	No	Yes	0	9	9
103	R:R:A128	R:R:Y219	6.67	No	Yes	0	8	9
104	R:R:F133	R:R:V129	3.93	No	No	0	5	6
105	R:R:D130	R:R:Y141	9.2	No	Yes	6	8	7
106	R:R:T136	R:R:Y132	17.48	No	Yes	7	7	8
107	R:R:V218	R:R:Y132	12.62	No	Yes	0	6	8
108	R:R:R221	R:R:Y132	14.4	No	Yes	7	5	8
109	R:R:F133	R:R:L145	7.31	No	No	0	5	7
110	R:R:A134	R:R:Y141	5.34	No	Yes	0	8	7
111	R:R:I135	R:R:V222	6.14	No	No	0	9	8
112	R:R:S137	R:R:T136	4.8	No	No	0	6	7
113	R:R:R221	R:R:T136	12.94	No	No	7	5	7
114	R:R:K140	R:R:S137	9.18	No	No	0	5	6
115	R:R:K140	R:R:L144	4.23	No	No	0	5	4
116	R:R:Q142	R:R:Y141	14.65	No	Yes	0	4	7
117	R:R:K147	R:R:R151	11.14	No	No	0	1	3
118	R:R:I153	R:R:K149	7.27	No	No	0	6	5
119	R:R:I159	R:R:L155	4.28	No	No	0	4	3
120	R:R:M156	R:R:V160	4.56	No	No	0	4	4
121	R:R:L163	R:R:L167	6.92	No	No	0	4	5
122	R:R:F166	R:R:S165	6.61	No	No	4	4	7
123	R:R:P168	R:R:W173	4.05	No	No	0	5	4
124	R:R:P168	R:R:Y199	4.17	No	Yes	0	5	6
125	R:R:I169	R:R:Q170	4.12	No	No	4	5	4
126	R:R:I169	R:R:Y174	18.13	No	Yes	0	5	5
127	R:R:M171	R:R:W173	10.47	No	No	0	4	4
128	R:R:F193	R:R:Y174	6.19	Yes	Yes	0	4	5
129	R:R:Y174	R:R:Y199	6.95	Yes	Yes	0	5	6
130	R:R:I182	R:R:R175	6.26	No	No	0	1	2
131	R:R:R175	R:R:Y185	4.12	No	No	0	2	1
132	R:R:N183	R:R:Q179	13.2	No	No	0	3	3
133	R:R:A181	R:R:F194	6.93	No	No	0	4	1
134	R:R:C184	R:R:C190	7.28	No	No	8	1	3
135	R:R:C184	R:R:D192	4.67	No	No	8	1	3
136	R:R:F194	R:R:Y185	5.16	No	No	0	1	1
137	R:R:C190	R:R:D192	6.22	No	No	8	3	3
138	R:R:F193	R:R:T195	9.08	Yes	No	0	4	3
139	R:R:F193	R:R:Y308	4.13	Yes	Yes	1	4	5
140	R:R:T195	R:R:Y199	8.74	No	Yes	0	3	6
141	R:R:I201	R:R:Q197	5.49	No	No	0	5	2
142	R:R:Q197	R:R:V297	5.73	No	No	0	2	5
143	R:R:S203	R:R:Y199	13.99	No	Yes	0	5	6
144	R:R:S204	R:R:Y209	3.82	No	No	0	5	5
145	R:R:F290	R:R:S204	5.28	Yes	No	0	7	5
146	R:R:N293	R:R:S204	4.47	No	No	0	5	5
147	R:R:F208	R:R:Y209	4.13	Yes	No	0	8	5
148	R:R:F208	R:R:L212	6.09	Yes	No	0	8	7
149	R:R:F208	R:R:F282	5.36	Yes	Yes	0	8	9
150	R:R:F208	R:R:L287	4.87	Yes	Yes	0	8	6
151	R:R:F208	R:R:F290	18.22	Yes	Yes	0	8	7
152	R:R:I294	R:R:Y209	6.04	No	No	0	6	5
153	R:R:P211	R:R:V210	7.07	No	No	0	8	5
154	R:R:M215	R:R:M279	5.78	No	No	0	8	8
155	R:R:F282	R:R:M215	9.95	Yes	No	0	9	8
156	R:R:V218	R:R:Y219	3.79	No	Yes	0	6	9
157	R:R:I278	R:R:Y219	9.67	Yes	Yes	0	8	9
158	R:R:M279	R:R:Y219	8.38	No	Yes	0	8	9
159	R:R:F223	R:R:L275	4.87	No	Yes	0	6	8
160	R:R:E225	R:R:R228	9.3	No	No	0	5	4
161	R:R:K232	R:R:R228	7.43	No	No	0	4	4
162	R:R:K232	R:R:Q229	4.07	No	No	0	4	7
163	R:R:E237	R:R:R239	5.82	No	No	0	3	4
164	R:R:C265	R:R:E268	9.12	No	No	0	3	7
165	R:R:H269	R:R:K273	7.86	No	No	0	5	7
166	R:R:I278	R:R:Y326	4.84	Yes	Yes	0	8	9
167	R:R:F321	R:R:T281	5.19	No	No	0	6	6
168	R:R:I325	R:R:T281	6.08	No	No	0	8	6
169	R:R:L287	R:R:T283	4.42	Yes	No	0	6	7
170	R:R:C285	R:R:N318	6.3	No	No	0	9	9
171	R:R:F290	R:R:W286	5.01	Yes	Yes	0	7	8
172	R:R:G315	R:R:W286	12.67	No	Yes	0	7	8
173	R:R:N318	R:R:W286	6.78	No	Yes	0	9	8
174	R:R:L287	R:R:P288	4.93	Yes	No	0	6	9
175	R:R:I291	R:R:L287	7.14	No	Yes	0	6	6
176	R:R:L311	R:R:P288	4.93	Yes	No	0	5	9
177	R:R:F289	R:R:F290	9.65	Yes	Yes	1	6	7
178	R:R:F289	R:R:Y308	11.35	Yes	Yes	1	6	5
179	R:R:F289	R:R:L311	6.09	Yes	Yes	0	6	5
180	R:R:F289	R:R:N312	20.54	Yes	No	1	6	5
181	R:R:L311	R:R:V292	4.47	Yes	No	0	5	5
182	R:R:N293	R:R:Y308	8.14	No	Yes	1	5	5
183	R:R:I303	R:R:V295	6.14	No	No	0	3	4
184	R:R:D300	R:R:H296	3.78	No	No	0	1	3
185	R:R:H296	R:R:I303	6.63	No	No	0	3	3
186	R:R:I298	R:R:Q299	5.49	No	No	0	4	2
187	R:R:L302	R:R:Q299	3.99	No	No	0	1	2
188	R:R:R304	R:R:V307	6.54	No	No	0	4	4
189	R:R:K305	R:R:Y308	7.17	No	Yes	0	2	5
190	R:R:N312	R:R:Y316	6.98	No	Yes	1	5	6
191	R:R:W313	R:R:Y316	7.72	Yes	Yes	1	5	6
192	R:R:F321	R:R:V317	6.55	No	No	0	6	5
193	R:R:N318	R:R:N322	5.45	No	Yes	0	9	9
194	R:R:I325	R:R:Y326	4.84	No	Yes	0	8	9
195	R:R:C327	R:R:F332	13.97	No	Yes	3	7	9
196	R:R:C327	R:R:F336	5.59	No	Yes	3	7	7
197	R:R:P330	R:R:S329	5.34	No	No	0	5	8
198	R:R:F332	R:R:S329	6.61	Yes	No	0	9	8
199	R:R:F332	R:R:F336	8.57	Yes	Yes	3	9	7
200	R:R:F49	R:R:L53	3.65	No	No	0	4	6
201	R:R:T110	R:R:W109	3.64	No	No	0	4	5
202	R:R:G280	R:R:T283	3.64	No	No	0	5	7
203	R:R:D130	R:R:F71	3.58	No	Yes	0	8	8
204	R:R:G35	R:R:I38	3.53	No	No	0	5	5
205	R:R:P323	R:R:V54	3.53	No	Yes	0	9	9
206	R:R:P88	R:R:V87	3.53	No	No	0	8	7
207	R:R:I43	R:R:W313	3.52	No	Yes	0	6	5
208	R:R:N196	R:R:Y199	3.49	No	Yes	0	4	6
209	R:R:C116	R:R:V81	3.42	No	No	0	7	7
210	R:R:A76	R:R:V54	3.39	No	Yes	0	9	9
211	R:R:L167	R:R:P168	3.28	No	No	0	5	5
212	R:R:A76	R:R:I55	3.25	No	No	0	9	7
213	R:R:A85	R:R:I112	3.25	No	No	0	4	4
214	R:R:T56	R:R:V52	3.17	No	No	0	5	3
215	R:R:A335	R:R:L64	3.15	No	Yes	0	7	8
216	R:R:T96	R:R:T98	3.14	No	No	2	4	5
217	R:R:A198	R:R:N196	3.13	No	No	0	4	4
218	R:R:F133	R:R:Y132	3.09	No	Yes	0	5	8
219	R:R:I43	R:R:V39	3.07	No	No	0	6	5
220	R:R:I112	R:R:V81	3.07	No	No	0	4	7
221	R:R:I112	R:R:V86	3.07	No	No	0	4	7
222	R:R:I303	R:R:V292	3.07	No	No	0	3	5
223	R:R:C190	R:R:E187	3.04	No	No	0	3	4
224	R:R:F49	R:R:G50	3.01	No	No	0	4	8
225	R:R:K149	R:R:T146	3	No	No	0	5	8
226	R:R:G238	R:R:R239	3	No	No	0	4	4
227	R:R:L212	R:R:V216	2.98	No	No	0	7	5
228	R:R:L311	R:R:V307	2.98	Yes	No	0	5	4
229	R:R:I294	R:R:I298	2.94	No	No	0	6	4
230	R:R:E122	R:R:V157	2.85	No	No	0	5	7
231	R:R:I159	R:R:L163	2.85	No	No	0	4	4
232	R:R:L95	R:R:M40	2.83	No	Yes	0	6	6
233	R:R:A57	R:R:F336	2.77	No	Yes	0	8	7
234	R:R:E225	R:R:I135	2.73	No	No	0	5	9
235	R:R:E237	R:R:I233	2.73	No	No	0	3	6
236	R:R:E268	R:R:L230	2.65	No	No	0	7	5
237	R:R:V222	R:R:Y132	2.52	No	Yes	0	8	8
238	R:R:F49	R:R:L340	2.44	No	No	0	4	6
239	R:R:L64	R:R:R63	2.43	Yes	No	0	8	6
240	R:R:I309	R:R:W313	2.35	No	Yes	0	3	5
241	R:R:E107	R:R:F104	2.33	No	No	0	5	1
242	R:R:R151	R:R:Y70	2.06	No	No	0	3	4
243	R:R:F217	R:R:Y132	2.06	No	Yes	0	4	8
244	R:R:G320	R:R:P323	2.03	No	No	0	7	9
245	R:R:Y174	R:R:Y185	1.99	Yes	No	0	5	1
246	R:R:G162	R:R:S161	1.86	No	No	0	4	8
247	R:R:G162	R:R:S165	1.86	No	No	0	4	7
248	R:R:G83	R:R:V48	1.84	No	No	0	7	6
249	R:R:P138	R:R:S137	1.78	No	No	0	8	6
250	R:R:G315	R:R:I314	1.76	No	No	0	7	7
251	R:R:G37	R:R:M40	1.75	No	Yes	0	5	6
252	R:R:G276	R:R:L275	1.71	No	Yes	0	6	8
253	R:R:A150	R:R:V67	1.7	No	No	0	7	6
254	R:R:A200	R:R:V297	1.7	No	No	0	5	5
255	R:R:A200	R:R:T195	1.68	No	No	0	5	3
256	R:R:S220	R:R:V216	1.62	No	No	0	3	5
257	R:R:G90	R:R:H93	1.59	No	No	0	7	4
258	R:R:T164	R:R:V206	1.59	No	No	0	5	4
259	R:R:A271	R:R:L230	1.58	No	No	0	8	5
260	R:R:T100	R:R:T96	1.57	No	No	2	2	4
261	R:R:T100	R:R:T98	1.57	No	No	2	2	5
262	R:R:I38	R:R:V34	1.54	No	No	0	5	5
263	R:R:I38	R:R:V39	1.54	No	No	0	5	5
264	R:R:I205	R:R:V210	1.54	No	No	0	4	5
265	R:R:L275	R:R:T274	1.47	Yes	No	0	8	8
266	R:R:I277	R:R:I278	1.47	No	Yes	0	7	8
267	R:R:I277	R:R:I325	1.47	No	No	0	7	8
268	R:R:L284	R:R:T283	1.47	No	No	0	5	7
269	R:R:N148	R:R:T146	1.46	No	No	0	4	8
270	R:R:I278	R:R:L275	1.43	Yes	Yes	0	8	8
271	R:R:I314	R:R:L310	1.43	No	No	0	7	5
272	R:R:E188	R:R:T189	1.41	No	No	0	3	4
273	R:R:K267	R:R:L230	1.41	No	No	0	6	5
274	R:R:I182	R:R:Q179	1.37	No	No	0	1	3
275	R:R:E338	R:R:I334	1.37	No	No	0	4	4
276	R:R:D300	R:R:N301	1.35	No	No	0	1	2
277	R:R:D234	R:R:Q231	1.31	No	No	0	4	5
278	R:R:F101	R:R:T100	1.3	Yes	No	2	5	2
279	R:R:F61	R:R:K60	1.24	Yes	No	0	6	5
280	R:R:F139	R:R:K140	1.24	No	No	0	6	5
281	R:R:E107	R:R:H172	1.23	No	No	0	5	4
282	R:R:N148	R:R:R151	1.21	No	No	0	4	3
283	R:R:F223	R:R:Q224	1.17	No	No	0	6	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.3567	12	1	0
2	R:R:M40	4.03667	6	1	6
3	R:R:V54	4.6475	4	3	9
4	R:R:F61	7.1875	4	0	6
5	R:R:L64	5.718	5	3	8
6	R:R:F71	6.138	5	0	8
7	R:R:L75	8.716	5	5	9
8	R:R:D79	8.344	5	5	9
9	R:R:W99	15.185	4	2	7
10	R:R:F101	14.435	4	2	5
11	R:R:L124	6.0275	4	5	8
12	R:R:Y132	8.695	6	7	8
13	R:R:Y141	8.8575	4	6	7
14	R:R:W158	5.86	4	0	9
15	R:R:Y174	8.315	4	0	5
16	R:R:F193	10.84	4	1	4
17	R:R:Y199	7.468	5	0	6
18	R:R:F208	7.734	5	0	8
19	R:R:Y219	7.1275	4	0	9
20	R:R:L275	2.37	4	0	8
21	R:R:I278	4.3525	4	0	8
22	R:R:F282	7.2425	4	0	9
23	R:R:W286	8.508	5	0	8
24	R:R:L287	5.34	4	0	6
25	R:R:F289	10.964	5	1	6
26	R:R:F290	9.39	5	1	7
27	R:R:Y308	7.388	5	1	5
28	R:R:L311	4.6175	4	0	5
29	R:R:W313	4.822	5	1	5
30	R:R:Y316	7.258	5	1	6
31	R:R:N322	9.5475	4	5	9
32	R:R:Y326	5.97833	6	5	9
33	R:R:F332	9.23286	7	3	9
34	R:R:F336	6.158	5	3	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D113	33.2286	17.8	Yes	No	1	0	7
2	R:R:D113	R:R:Y316	24.7796	11.49	No	Yes	1	7	6
3	R:R:W313	R:R:Y316	60.2776	7.72	Yes	Yes	1	5	6
4	R:R:M40	R:R:W313	28.4368	4.65	Yes	Yes	1	6	5
5	R:R:M36	R:R:M40	12.4815	4.33	No	Yes	0	5	6
6	L:L:?1	R:R:N312	26.6475	13.51	Yes	No	1	0	5
7	R:R:N312	R:R:Y316	38.7012	6.98	No	Yes	1	5	6
8	R:R:V87	R:R:Y316	31.8408	5.05	No	Yes	0	7	6
9	R:R:I47	R:R:V87	27.7821	4.61	No	No	0	8	7
10	R:R:I47	R:R:S319	25.9754	4.64	No	No	0	8	9
11	L:L:?1	R:R:V117	15.1349	6.84	Yes	No	0	0	6
12	R:R:V117	R:R:W286	15.9553	11.03	No	Yes	0	6	8
13	R:R:N318	R:R:W286	30.165	6.78	No	Yes	0	9	8
14	R:R:N318	R:R:N322	29.1176	5.45	No	Yes	0	9	9
15	R:R:D79	R:R:N322	10.4914	10.77	Yes	Yes	5	9	9
16	L:L:?1	R:R:F290	87.7629	8.79	Yes	Yes	1	0	7
17	R:R:F290	R:R:W286	21.393	5.01	Yes	Yes	0	7	8
18	R:R:D79	R:R:N51	11.1984	6.73	Yes	No	0	9	9
19	R:R:F208	R:R:F290	91.3066	18.22	Yes	Yes	0	8	7
20	R:R:F208	R:R:F282	100	5.36	Yes	Yes	0	8	9
21	R:R:F282	R:R:L124	71.0832	4.87	Yes	Yes	0	9	8
22	R:R:L124	R:R:Y326	53.2164	8.21	Yes	Yes	5	8	9
23	R:R:I72	R:R:Y326	74.1468	6.04	No	Yes	0	8	9
24	R:R:F332	R:R:I72	72.3837	3.77	Yes	No	0	9	8
25	R:R:F332	R:R:F336	26.4904	8.57	Yes	Yes	3	9	7
26	R:R:C327	R:R:F332	15.4491	13.97	No	Yes	3	7	9
27	R:R:C327	R:R:V54	13.2932	5.12	No	Yes	3	7	9
28	R:R:F336	R:R:V54	13.555	6.55	Yes	Yes	3	7	9
29	R:R:A76	R:R:V54	13.5027	3.39	No	Yes	0	9	9
30	R:R:F332	R:R:L64	20.3369	14.61	Yes	Yes	3	9	8
31	R:R:A335	R:R:L64	13.9216	3.15	No	Yes	0	7	8
32	R:R:A335	R:R:F61	11.6435	9.71	No	Yes	0	7	6
33	R:R:L75	R:R:N322	17.9715	16.48	Yes	Yes	5	9	9
34	R:R:L75	R:R:T123	58.2264	7.37	Yes	No	0	9	8
35	R:R:S74	R:R:T123	56.0618	6.4	No	No	0	9	8
36	R:R:I154	R:R:S74	48.058	7.74	No	No	0	8	9
37	R:R:F71	R:R:I154	45.5268	7.54	Yes	No	0	8	8
38	R:R:F71	R:R:I153	22.1262	7.54	Yes	No	0	8	6
39	R:R:I153	R:R:K149	19.4204	7.27	No	No	0	6	5
40	R:R:K149	R:R:T146	16.6972	3	No	No	0	5	8
41	R:R:N148	R:R:T146	13.9565	1.46	No	No	0	4	8
42	R:R:N148	R:R:R151	11.1984	1.21	No	No	0	4	3
43	R:R:L124	R:R:L75	18.6349	5.54	Yes	Yes	5	8	9
44	R:R:D130	R:R:F71	13.782	3.58	No	Yes	0	8	8
45	L:L:?1	R:R:F193	39.0504	23.96	Yes	Yes	1	0	4
46	R:R:F193	R:R:Y174	32.5565	6.19	Yes	Yes	0	4	5
47	R:R:I169	R:R:Y174	21.393	18.13	No	Yes	0	5	5
48	R:R:I169	R:R:S111	12.5251	7.74	No	No	4	5	6
49	R:R:F166	R:R:S111	15.9902	7.93	No	No	4	4	6
50	R:R:F166	R:R:L115	14.7857	9.74	No	No	4	4	5
51	R:R:L115	R:R:W158	20.686	6.83	No	Yes	0	5	9
52	L:L:?1	R:R:S207	18.9578	3.94	Yes	No	0	0	5
53	R:R:S207	R:R:T118	17.1336	9.59	No	No	0	5	6
54	R:R:S161	R:R:T118	11.3206	6.4	No	No	0	8	6
55	L:L:?1	R:R:W109	39.0154	6.72	Yes	No	0	0	5
56	R:R:F89	R:R:W109	33.8221	9.02	No	No	0	5	5
57	R:R:F101	R:R:F89	25.443	20.36	Yes	No	2	5	5
58	R:R:F101	R:R:W99	14.3929	31.07	Yes	Yes	2	5	7
59	R:R:F282	R:R:M215	45.5617	9.95	Yes	No	0	9	8
60	R:R:C125	R:R:M215	13.4328	4.86	No	No	0	7	8
61	R:R:M215	R:R:M279	32.5216	5.78	No	No	0	8	8
62	R:R:M279	R:R:Y219	31.448	8.38	No	Yes	0	8	9
63	R:R:V218	R:R:Y219	48.9133	3.79	No	Yes	0	6	9
64	R:R:V218	R:R:Y132	46.4956	12.62	No	Yes	0	6	8
65	R:R:T136	R:R:Y132	16.0688	17.48	No	Yes	7	7	8
66	R:R:V222	R:R:Y132	16.1211	2.52	No	Yes	0	8	8
67	R:R:I135	R:R:V222	13.4677	6.14	No	No	0	9	8
68	R:R:S137	R:R:T136	13.4765	4.8	No	No	0	6	7
69	L:L:?1	R:R:S203	23.1125	9.85	Yes	No	0	0	5
70	R:R:S203	R:R:Y199	21.1486	13.99	No	Yes	0	5	6
71	R:R:P168	R:R:Y199	17.893	4.17	No	Yes	0	5	6
72	R:R:L167	R:R:P168	10.3256	3.28	No	No	0	5	5
73	R:R:Y174	R:R:Y185	18.6262	1.99	Yes	No	0	5	1
74	R:R:R175	R:R:Y185	10.7969	4.12	No	No	0	2	1
75	R:R:F193	R:R:T195	13.1273	9.08	Yes	No	0	4	3
76	R:R:A200	R:R:T195	12.0712	1.68	No	No	0	5	3
77	R:R:F290	R:R:S204	10.4565	5.28	Yes	No	0	7	5
78	R:R:S204	R:R:Y209	14.358	3.82	No	No	0	5	5
79	R:R:F208	R:R:Y209	15.0825	4.13	Yes	No	0	8	5
80	R:R:F208	R:R:L287	22.8856	4.87	Yes	Yes	0	8	6
81	R:R:I294	R:R:Y209	20.4329	6.04	No	No	0	6	5
82	R:R:I278	R:R:Y326	36.4406	4.84	Yes	Yes	0	8	9
83	R:R:I278	R:R:L275	11.6697	1.43	Yes	Yes	0	8	8
84	R:R:E225	R:R:I135	10.8056	2.73	No	No	0	5	9
85	R:R:I325	R:R:Y326	11.2857	4.84	No	Yes	0	8	9
86	R:R:G315	R:R:W286	12.848	12.67	No	Yes	0	7	8
87	R:R:F289	R:R:L311	25.1287	6.09	Yes	Yes	0	6	5
88	R:R:L311	R:R:P288	11.6959	4.93	Yes	No	0	5	9
89	R:R:L311	R:R:V292	21.6723	4.47	Yes	No	0	5	5
90	R:R:I303	R:R:V292	18.1025	3.07	No	No	0	3	5
91	R:R:H296	R:R:I303	10.9104	6.63	No	No	0	3	3
92	R:R:I294	R:R:I298	15.3618	2.94	No	No	0	6	4
93	R:R:I298	R:R:Q299	10.2557	5.49	No	No	0	4	2
94	R:R:I43	R:R:W313	20.721	3.52	No	Yes	0	6	5
95	R:R:I43	R:R:V39	16.6099	3.07	No	No	0	6	5
96	R:R:I38	R:R:V39	12.4815	1.54	No	No	0	5	5
97	R:R:D79	R:R:S319	30.645	8.83	Yes	No	0	9	9
98	R:R:D79	R:R:L75	33.6039	9.5	Yes	Yes	5	9	9
99	R:R:L75	R:R:Y326	48.7388	4.69	Yes	Yes	5	9	9
100	R:R:S74	R:R:W158	22.6761	4.94	No	Yes	0	9	9
101	R:R:F289	R:R:N312	15.1785	20.54	Yes	No	1	6	5
102	R:R:F289	R:R:F290	27.4156	9.65	Yes	Yes	1	6	7
103	R:R:L287	R:R:P288	11.757	4.93	Yes	No	0	6	9
104	R:R:I278	R:R:Y219	24.6661	9.67	Yes	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W109	6.72	1	Yes	No	0	5	0	1
L:L:?1	R:R:D113	17.8	1	Yes	No	0	7	0	1
L:L:?1	R:R:V114	7.82	1	Yes	No	0	5	0	1
L:L:?1	R:R:V117	6.84	1	Yes	No	0	6	0	1
L:L:?1	R:R:F193	23.96	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S203	9.85	1	Yes	No	0	5	0	1
L:L:?1	R:R:S207	3.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:F289	7.19	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F290	8.79	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N293	11.71	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y308	6.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N312	13.51	1	Yes	No	0	5	0	1
R:R:D113	R:R:V86	7.3	1	No	No	7	7	1	2
R:R:V86	R:R:Y316	5.05	1	No	Yes	7	6	2	2
R:R:F89	R:R:W109	9.02	2	No	No	5	5	2	1
R:R:D113	R:R:Y316	11.49	1	No	Yes	7	6	1	2
R:R:V117	R:R:W286	11.03	0	No	Yes	6	8	1	2
R:R:S207	R:R:T118	9.59	0	No	No	5	6	1	2
R:R:F193	R:R:Y174	6.19	1	Yes	Yes	4	5	1	2
R:R:Y174	R:R:Y199	6.95	0	Yes	Yes	5	6	2	2
R:R:F193	R:R:T195	9.08	1	Yes	No	4	3	1	2
R:R:F193	R:R:Y308	4.13	1	Yes	Yes	4	5	1	1
R:R:T195	R:R:Y199	8.74	0	No	Yes	3	6	2	2
R:R:S203	R:R:Y199	13.99	0	No	Yes	5	6	1	2
R:R:F290	R:R:S204	5.28	1	Yes	No	7	5	1	2
R:R:N293	R:R:S204	4.47	1	No	No	5	5	1	2
R:R:F208	R:R:F290	18.22	0	Yes	Yes	8	7	2	1
R:R:F290	R:R:W286	5.01	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:F290	9.65	1	Yes	Yes	6	7	1	1
R:R:F289	R:R:Y308	11.35	1	Yes	Yes	6	5	1	1
R:R:F289	R:R:L311	6.09	1	Yes	Yes	6	5	1	2
R:R:F289	R:R:N312	20.54	1	Yes	No	6	5	1	1
R:R:N293	R:R:Y308	8.14	1	No	Yes	5	5	1	1
R:R:K305	R:R:Y308	7.17	0	No	Yes	2	5	2	1
R:R:N312	R:R:Y316	6.98	1	No	Yes	5	6	1	2
R:R:T110	R:R:W109	3.64	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	3SN6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	254
Number of Links	283
Number of Hubs	34
Number of Links mediated by Hubs	135
Number of Communities	8
Number of Nodes involved in Communities	49
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	105
Number Of Links MetaPath	104
Number of Shortest Paths	40385
Length Of Smallest Path	3
Average Path Length	10.7425
Length of Longest Path	23
Minimum Path Strength	1.335
Average Path Strength	7.43556
Maximum Path Strength	25.715
Minimum Path Correlation	0.7
Average Path Correlation	0.931539
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	57.8372
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.5103
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • amide binding • amyloid-beta binding • binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • monoatomic cation transmembrane transporter activity • channel regulator activity • ion channel regulator activity • monoatomic ion channel activity • potassium ion transmembrane transporter activity • potassium channel activity • potassium channel regulator activity • monoatomic cation channel activity • passive transmembrane transporter activity • inorganic molecular entity transmembrane transporter activity • channel activity • molecular function regulator activity • inorganic cation transmembrane transporter activity • monoatomic ion transmembrane transporter activity • transporter activity • transporter regulator activity • metal ion transmembrane transporter activity • transmembrane transporter activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • regulation of biological process • bone mineralization • animal organ development • biological regulation • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • positive regulation of phosphorylation • regulation of catalytic activity • regulation of transferase activity • positive regulation of phosphate metabolic process • cell surface receptor protein tyrosine kinase signaling pathway • cellular component biogenesis • cellular component assembly • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • activation of transmembrane receptor protein tyrosine kinase activity • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of molecular function • positive regulation of kinase activity • regulation of kinase activity • activation of protein kinase activity • macromolecule modification • regulation of phosphorus metabolic process • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • cellular component organization • positive regulation of molecular function • positive regulation of protein modification process • protein-containing complex assembly • cellular component organization or biogenesis • protein metabolic process • positive regulation of protein kinase activity • enzyme-linked receptor protein signaling pathway • positive regulation of transferase activity • cell surface receptor signaling pathway • protein-containing complex organization • positive regulation of catalytic activity • regulation of protein kinase activity • regulation of phosphorylation • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • autophagosome maturation • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • apical part of cell • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • sensory perception of chemical stimulus • sensory perception • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • cytoskeletal protein binding • spectrin binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • cell projection membrane • synapse • cell junction • cell body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Galpha insert domain-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Galpha insert domain-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P0G
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P0G
Name	8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one
Synonyms
Identifier
Formula	C21 H26 N2 O4
Molecular Weight	370.442
SMILES
PubChem	49837874
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	1
Total Bonds	55
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>3SN6_nogp_Chain_R E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L T K T W T F G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S F L P I Q M H W Y R Q E A I N C Y A E E T C C D F F T N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E G R C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q D N L I R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E L L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9CHV	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.95	2024-11-13	10.1073/pnas.2414544121
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Noradrenaline	-	-	3.49	2024-11-13	10.1073/pnas.2414544121
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.5	2024-11-13	10.1073/pnas.2414544121
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	8W1V (Multimeric)	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-		3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	10.1038/s41467-023-37808-y
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	10.1038/s41589-023-01389-0
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Formoterol	-	-	3.2	2023-09-06	10.1038/s41589-023-01389-0
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	10.1093/nsr/nwaa284
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	10.1093/nsr/nwaa284
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	10.1038/s41421-020-0176-9
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	GTPL11074	-	3.1	2020-03-25	10.1038/s41589-020-0549-2
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	10.1038/s41594-019-0330-y
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	S-Propranolol	-	-	2.9	2019-11-13	10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carvedilol	-	-	2.5	2019-11-13	10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.4	2019-11-13	10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.4	2019-11-13	10.1107/S2052252519013137
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.8	2019-11-13	10.1107/S2052252519013137
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	10.1126/science.aaw8981
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs (fused)	3.7	2019-06-05	10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	10.1016/j.cell.2019.04.021
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	10.1038/s41589-018-0145-x
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	PubChem 129318963	-	2.7	2017-08-16	10.1038/nature23652
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-08-17	10.1038/nprot.2017.057
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-07-13	10.1038/nature18636
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.8	2016-01-13	10.1107/S2059798315021683
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.48	2016-01-13	10.1107/S2059798315021683
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	35V	-	-	3.3	2014-07-23	10.1073/pnas.1410415111
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	L-Epinephrine	-	-	3.2	2013-09-25	10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.1	2013-09-25	10.1038/nature12572
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	10.1038/nature12572
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.99	2012-10-24	10.1371/journal.pone.0046039
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	10.1038/nature10361
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	10.1038/nature09648
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.5	2011-01-12	10.1038/nature09665
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	3.16	2010-08-11	10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	10.1021/ja105108q
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	10.1021/ja105108q
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	10.1038/nature08650
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	10.1016/j.str.2008.05.001
	2R4S	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	10.1038/nature06325
	2R4R	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	10.1038/nature06325
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	10.1126/science.1150577

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 3SN6_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.