psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D113	12.62	Yes	No	1	0	7
2	L:L:?1	R:R:V114	4.16	Yes	No	0	0	5
3	L:L:?1	R:R:V117	11.09	Yes	No	0	0	6
4	L:L:?1	R:R:F193	4.53	Yes	Yes	0	0	4
5	L:L:?1	R:R:S203	2.79	Yes	No	0	0	5
6	L:L:?1	R:R:F289	9.06	Yes	Yes	1	0	6
7	L:L:?1	R:R:N293	6.39	Yes	Yes	1	0	5
8	L:L:?1	R:R:N312	8.94	Yes	No	1	0	5
9	L:L:?1	R:R:Y316	5.45	Yes	Yes	1	0	6
10	R:R:M36	R:R:W32	3.49	No	No	0	5	3
11	R:R:G35	R:R:V34	3.68	No	No	0	5	5
12	R:R:M36	R:R:M40	8.66	No	Yes	1	5	6
13	R:R:L95	R:R:M36	2.83	No	No	1	6	5
14	R:R:G37	R:R:L95	3.42	No	No	0	5	6
15	R:R:I38	R:R:S41	3.1	No	No	0	5	4
16	R:R:I38	R:R:L42	2.85	No	No	0	5	5
17	R:R:A91	R:R:M40	4.83	No	Yes	0	6	6
18	R:R:I94	R:R:M40	4.37	No	Yes	1	5	6
19	R:R:L95	R:R:M40	2.83	No	Yes	1	6	6
20	R:R:M40	R:R:W313	11.63	Yes	Yes	1	6	5
21	R:R:I43	R:R:I47	2.94	No	No	0	6	8
22	R:R:I43	R:R:V317	4.61	No	No	0	6	5
23	R:R:V44	R:R:V87	3.21	No	Yes	1	6	7
24	R:R:P88	R:R:V44	5.3	No	No	1	8	6
25	R:R:I47	R:R:N51	2.83	No	Yes	0	8	9
26	R:R:L80	R:R:V48	2.98	Yes	No	6	7	6
27	R:R:L84	R:R:V48	2.98	No	No	6	5	6
28	R:R:F49	R:R:L53	3.65	No	No	0	4	6
29	R:R:D79	R:R:N51	10.77	Yes	Yes	0	9	9
30	R:R:L80	R:R:N51	2.75	Yes	Yes	0	7	9
31	R:R:N51	R:R:P323	3.26	Yes	No	0	9	9
32	R:R:L80	R:R:V52	2.98	Yes	No	0	7	3
33	R:R:C327	R:R:V54	6.83	No	No	0	7	9
34	R:R:A76	R:R:I55	3.25	No	No	0	9	7
35	R:R:A57	R:R:F336	2.77	No	No	0	8	7
36	R:R:I58	R:R:N69	5.66	No	Yes	4	7	9
37	R:R:I58	R:R:T73	6.08	No	No	0	7	6
38	R:R:F332	R:R:I58	5.02	Yes	No	4	9	7
39	R:R:A335	R:R:F61	5.55	No	No	0	7	6
40	R:R:E338	R:R:F61	5.83	No	No	0	4	6
41	R:R:E62	R:R:Q65	6.37	No	No	0	6	8
42	R:R:L64	R:R:N69	2.75	No	Yes	4	8	9
43	R:R:F332	R:R:L64	7.31	Yes	No	4	9	8
44	R:R:N69	R:R:T66	5.85	Yes	No	0	9	7
45	R:R:L145	R:R:V67	2.98	No	No	0	7	6
46	R:R:D130	R:R:T68	5.78	No	No	0	8	8
47	R:R:F332	R:R:N69	6.04	Yes	Yes	4	9	9
48	R:R:K147	R:R:Y70	13.14	No	No	0	1	4
49	R:R:R151	R:R:Y70	7.2	No	No	0	3	4
50	R:R:F71	R:R:V126	7.87	Yes	No	0	8	7
51	R:R:F71	R:R:I127	3.77	Yes	No	0	8	9
52	R:R:D130	R:R:F71	8.36	No	Yes	0	8	8
53	R:R:A150	R:R:F71	2.77	No	Yes	0	7	8
54	R:R:F71	R:R:I154	5.02	Yes	No	0	8	8
55	R:R:C327	R:R:I72	3.27	No	No	0	7	8
56	R:R:S74	R:R:T123	4.8	No	No	0	9	8
57	R:R:I154	R:R:S74	6.19	No	No	0	8	9
58	R:R:S74	R:R:W158	6.18	No	Yes	0	9	9
59	R:R:D79	R:R:L75	8.14	Yes	Yes	3	9	9
60	R:R:L75	R:R:S120	3	Yes	No	3	9	9
61	R:R:L75	R:R:T123	5.9	Yes	No	0	9	8
62	R:R:L124	R:R:L75	4.15	No	Yes	0	8	9
63	R:R:L75	R:R:N322	10.98	Yes	No	3	9	9
64	R:R:D79	R:R:S120	2.94	Yes	No	3	9	9
65	R:R:D79	R:R:S319	10.31	Yes	No	0	9	9
66	R:R:D79	R:R:N322	6.73	Yes	No	3	9	9
67	R:R:L80	R:R:L84	6.92	Yes	No	6	7	5
68	R:R:C116	R:R:V81	3.42	No	No	0	7	7
69	R:R:C116	R:R:M82	4.86	No	No	0	7	7
70	R:R:M82	R:R:V117	3.04	No	No	0	7	6
71	R:R:M82	R:R:S319	6.13	No	No	0	7	9
72	R:R:G83	R:R:V87	3.68	No	Yes	0	7	7
73	R:R:D113	R:R:V86	11.69	No	No	1	7	7
74	R:R:V86	R:R:Y316	3.79	No	Yes	1	7	6
75	R:R:P88	R:R:V87	3.53	No	Yes	1	8	7
76	R:R:V87	R:R:W313	3.68	Yes	Yes	1	7	5
77	R:R:F101	R:R:F89	3.22	Yes	No	0	5	5
78	R:R:F89	R:R:W109	4.01	No	Yes	0	5	5
79	R:R:G90	R:R:W109	2.81	No	Yes	0	7	5
80	R:R:H93	R:R:W99	6.35	No	Yes	5	4	7
81	R:R:C191	R:R:H93	2.95	No	No	5	9	4
82	R:R:I309	R:R:I94	2.94	No	No	0	3	5
83	R:R:I94	R:R:W313	4.7	No	Yes	1	5	5
84	R:R:M96	R:R:T100	4.52	No	No	0	4	2
85	R:R:M98	R:R:T189	7.53	No	No	0	5	4
86	R:R:F101	R:R:W99	5.01	Yes	Yes	0	5	7
87	R:R:C106	R:R:W99	5.22	No	Yes	5	9	7
88	R:R:W109	R:R:W99	3.75	Yes	Yes	0	5	7
89	R:R:C191	R:R:W99	13.06	No	Yes	5	9	7
90	R:R:F101	R:R:W105	7.02	Yes	No	0	5	5
91	R:R:E188	R:R:N103	7.89	No	No	0	3	2
92	R:R:C106	R:R:C191	5.46	No	No	5	9	9
93	R:R:E107	R:R:H172	3.69	No	No	2	5	4
94	R:R:E107	R:R:R175	3.49	No	No	2	5	2
95	R:R:F108	R:R:F166	4.29	No	Yes	0	5	4
96	R:R:F193	R:R:T110	3.89	Yes	No	0	4	4
97	R:R:F166	R:R:S111	10.57	Yes	No	2	4	6
98	R:R:I169	R:R:S111	6.19	No	No	2	5	6
99	R:R:Q170	R:R:S111	4.33	No	No	2	4	6
100	R:R:D113	R:R:Y316	9.2	No	Yes	1	7	6
101	R:R:S165	R:R:V114	3.23	Yes	No	0	7	5
102	R:R:L115	R:R:W158	4.56	No	Yes	0	5	9
103	R:R:L115	R:R:S161	3	No	No	0	5	8
104	R:R:L115	R:R:S165	6.01	No	Yes	0	5	7
105	R:R:V117	R:R:W286	4.9	No	Yes	0	6	8
106	R:R:S161	R:R:T118	3.2	No	No	0	8	6
107	R:R:S207	R:R:T118	6.4	No	No	0	5	6
108	R:R:A119	R:R:W158	7.78	No	Yes	0	7	9
109	R:R:I121	R:R:P211	3.39	No	Yes	0	7	8
110	R:R:F282	R:R:I121	3.77	Yes	No	0	9	7
111	R:R:P211	R:R:W122	13.51	Yes	No	0	8	5
112	R:R:L124	R:R:M215	2.83	No	Yes	0	8	8
113	R:R:L124	R:R:Y326	3.52	No	Yes	0	8	9
114	R:R:C125	R:R:P211	3.77	No	Yes	0	7	8
115	R:R:C125	R:R:I214	4.91	No	No	0	7	6
116	R:R:C125	R:R:M215	4.86	No	Yes	0	7	8
117	R:R:I153	R:R:V126	3.07	No	No	0	6	7
118	R:R:I127	R:R:Y326	3.63	No	Yes	0	9	9
119	R:R:A128	R:R:M215	3.22	No	Yes	0	8	8
120	R:R:A128	R:R:Y219	6.67	No	Yes	0	8	9
121	R:R:D130	R:R:Y141	8.05	No	No	0	8	7
122	R:R:R131	R:R:Y326	4.12	No	Yes	0	9	9
123	R:R:F133	R:R:Y132	5.16	No	Yes	0	5	8
124	R:R:T136	R:R:Y132	12.48	No	Yes	0	7	8
125	R:R:V218	R:R:Y132	8.83	No	Yes	0	6	8
126	R:R:R221	R:R:Y132	3.09	Yes	Yes	0	5	8
127	R:R:A134	R:R:Y141	9.34	No	No	0	8	7
128	R:R:E225	R:R:I135	2.73	No	No	0	5	9
129	R:R:K140	R:R:L144	2.82	No	No	0	5	4
130	R:R:L145	R:R:Y141	7.03	No	No	0	7	7
131	R:R:L144	R:R:S143	4.5	No	No	0	4	4
132	R:R:K149	R:R:T146	6.01	No	No	0	5	8
133	R:R:L163	R:R:L167	2.77	No	No	0	4	5
134	R:R:F166	R:R:S165	5.28	Yes	Yes	0	4	7
135	R:R:F166	R:R:Q170	4.68	Yes	No	2	4	4
136	R:R:L167	R:R:P168	3.28	No	No	0	5	5
137	R:R:P168	R:R:Y199	2.78	No	Yes	0	5	6
138	R:R:I169	R:R:Y174	12.09	No	Yes	2	5	5
139	R:R:I169	R:R:Y199	4.84	No	Yes	2	5	6
140	R:R:M171	R:R:W173	13.96	No	No	0	4	4
141	R:R:H172	R:R:R175	20.31	No	No	2	4	2
142	R:R:F193	R:R:Y174	7.22	Yes	Yes	0	4	5
143	R:R:Y174	R:R:Y199	6.95	Yes	Yes	2	5	6
144	R:R:R175	R:R:Y185	17.49	No	No	2	2	1
145	R:R:A176	R:R:H178	2.93	No	No	0	1	2
146	R:R:A181	R:R:H178	7.32	No	No	2	4	2
147	R:R:F194	R:R:H178	6.79	Yes	No	2	1	2
148	R:R:E180	R:R:F194	7	No	Yes	0	3	1
149	R:R:A181	R:R:Y185	5.34	No	No	2	4	1
150	R:R:A181	R:R:F194	4.16	No	Yes	2	4	1
151	R:R:C184	R:R:C190	7.28	No	No	0	1	3
152	R:R:C184	R:R:F194	4.19	No	Yes	0	1	1
153	R:R:F194	R:R:Y185	4.13	Yes	No	2	1	1
154	R:R:D192	R:R:F194	9.55	No	Yes	0	3	1
155	R:R:F193	R:R:T195	7.78	Yes	No	0	4	3
156	R:R:T195	R:R:Y199	3.75	No	Yes	0	3	6
157	R:R:A198	R:R:N196	3.13	No	No	0	4	4
158	R:R:Q197	R:R:V297	2.87	No	No	0	2	5
159	R:R:I298	R:R:Q197	4.12	No	No	0	4	2
160	R:R:S203	R:R:Y199	6.36	No	Yes	0	5	6
161	R:R:A200	R:R:V297	5.09	No	No	0	5	5
162	R:R:I201	R:R:I205	2.94	No	No	0	5	4
163	R:R:F290	R:R:S204	5.28	Yes	No	0	7	5
164	R:R:N293	R:R:S204	7.45	Yes	No	0	5	5
165	R:R:I294	R:R:S204	6.19	No	No	0	6	5
166	R:R:F208	R:R:Y209	8.25	Yes	No	1	8	5
167	R:R:F208	R:R:L212	7.31	Yes	No	1	8	7
168	R:R:F208	R:R:F282	7.5	Yes	Yes	1	8	9
169	R:R:F208	R:R:W286	3.01	Yes	Yes	1	8	8
170	R:R:F208	R:R:L287	3.65	Yes	No	0	8	6
171	R:R:F208	R:R:F290	20.36	Yes	Yes	1	8	7
172	R:R:F290	R:R:Y209	3.09	Yes	No	1	7	5
173	R:R:P211	R:R:V210	3.53	Yes	No	0	8	5
174	R:R:I214	R:R:V210	3.07	No	No	0	6	5
175	R:R:F282	R:R:L212	3.65	Yes	No	1	9	7
176	R:R:F282	R:R:M215	3.73	Yes	Yes	0	9	8
177	R:R:F217	R:R:R221	3.21	No	Yes	0	4	5
178	R:R:I278	R:R:Y219	6.04	No	Yes	7	8	9
179	R:R:M279	R:R:Y219	4.79	No	Yes	7	8	9
180	R:R:Q224	R:R:S220	2.89	No	No	0	3	3
181	R:R:Q224	R:R:R221	3.5	No	Yes	0	3	5
182	R:R:E225	R:R:R221	3.49	No	Yes	0	5	5
183	R:R:F223	R:R:K227	7.44	Yes	No	0	6	6
184	R:R:A271	R:R:F223	2.77	No	Yes	0	8	6
185	R:R:F223	R:R:L272	6.09	Yes	No	0	6	7
186	R:R:F223	R:R:L275	3.65	Yes	No	0	6	8
187	R:R:E225	R:R:R228	11.63	No	No	0	5	4
188	R:R:E268	R:R:K227	6.75	No	No	0	7	6
189	R:R:Q229	R:R:R228	3.5	No	No	8	7	4
190	R:R:K232	R:R:R228	7.43	No	No	8	4	4
191	R:R:K232	R:R:Q229	8.14	No	No	8	4	7
192	R:R:E237	R:R:I233	4.1	No	No	0	3	6
193	R:R:D234	R:R:G238	3.35	No	No	0	4	4
194	R:R:E268	R:R:L272	2.65	No	No	0	7	7
195	R:R:I277	R:R:I325	2.94	No	No	0	7	8
196	R:R:I277	R:R:R328	8.77	No	No	0	7	7
197	R:R:I278	R:R:M279	2.92	No	No	7	8	8
198	R:R:N318	R:R:T281	2.92	Yes	No	0	9	6
199	R:R:L287	R:R:T283	4.42	No	No	0	6	7
200	R:R:C285	R:R:N318	4.72	No	Yes	0	9	9
201	R:R:F289	R:R:W286	7.02	Yes	Yes	1	6	8
202	R:R:F290	R:R:W286	4.01	Yes	Yes	1	7	8
203	R:R:G315	R:R:W286	9.85	No	Yes	0	7	8
204	R:R:N318	R:R:W286	3.39	Yes	Yes	0	9	8
205	R:R:I291	R:R:L287	5.71	No	No	0	6	6
206	R:R:L311	R:R:P288	3.28	No	No	0	5	9
207	R:R:F289	R:R:F290	7.5	Yes	Yes	1	6	7
208	R:R:F289	R:R:N293	3.62	Yes	Yes	1	6	5
209	R:R:F289	R:R:Y308	8.25	Yes	Yes	1	6	5
210	R:R:F289	R:R:N312	9.67	Yes	No	1	6	5
211	R:R:I303	R:R:V292	6.14	Yes	No	0	3	5
212	R:R:L311	R:R:V292	2.98	No	No	0	5	5
213	R:R:N293	R:R:Y308	3.49	Yes	Yes	1	5	5
214	R:R:I303	R:R:V295	3.07	Yes	No	0	3	4
215	R:R:H296	R:R:V297	6.92	No	No	0	3	5
216	R:R:H296	R:R:I303	2.65	No	Yes	0	3	3
217	R:R:H296	R:R:Y308	9.8	No	Yes	0	3	5
218	R:R:L302	R:R:Q299	6.65	No	No	0	1	2
219	R:R:D300	R:R:N301	2.69	No	No	0	1	2
220	R:R:I303	R:R:L302	2.85	Yes	No	0	3	1
221	R:R:I303	R:R:V307	3.07	Yes	No	0	3	4
222	R:R:E306	R:R:R304	13.96	No	No	0	2	4
223	R:R:K305	R:R:Y308	7.17	No	Yes	0	2	5
224	R:R:I309	R:R:K305	5.82	No	No	0	3	2
225	R:R:L311	R:R:V307	2.98	No	No	0	5	4
226	R:R:I314	R:R:L310	2.85	No	No	0	7	5
227	R:R:N312	R:R:Y316	9.3	No	Yes	1	5	6
228	R:R:W313	R:R:Y316	6.75	Yes	Yes	1	5	6
229	R:R:N318	R:R:N322	2.72	Yes	No	0	9	9
230	R:R:I325	R:R:Y326	4.84	No	Yes	0	8	9
231	R:R:C327	R:R:F332	13.97	No	Yes	0	7	9
232	R:R:P330	R:R:S329	3.56	No	No	0	5	8
233	R:R:F332	R:R:S329	3.96	Yes	No	0	9	8
234	R:R:F332	R:R:F336	7.5	Yes	No	0	9	7
235	R:R:E338	R:R:I334	4.1	No	No	0	4	4
236	R:R:L339	R:R:L340	4.15	No	No	0	6	6
237	R:R:F133	R:R:V129	2.62	No	No	0	5	6
238	R:R:A78	R:R:W158	2.59	No	Yes	0	8	9
239	R:R:V222	R:R:Y132	2.52	No	Yes	0	8	8
240	R:R:V218	R:R:Y219	2.52	No	Yes	0	6	9
241	R:R:F166	R:R:I112	2.51	Yes	No	0	4	4
242	R:R:V86	R:R:W109	2.45	No	Yes	0	7	5
243	R:R:I72	R:R:Y326	2.42	No	Yes	0	8	9
244	R:R:L275	R:R:Y219	2.34	No	Yes	0	8	9
245	R:R:N196	R:R:Y199	2.33	No	Yes	0	4	6
246	R:R:E107	R:R:Y174	2.24	No	Yes	2	5	5
247	R:R:G50	R:R:P323	2.03	No	No	0	8	9
248	R:R:F104	R:R:W105	2	No	No	0	1	5
249	R:R:G162	R:R:S161	1.86	No	No	0	4	8
250	R:R:G162	R:R:S165	1.86	No	Yes	0	4	7
251	R:R:A335	R:R:A57	1.79	No	No	0	7	8
252	R:R:P138	R:R:S137	1.78	No	No	0	8	6
253	R:R:G35	R:R:I38	1.76	No	No	0	5	5
254	R:R:G320	R:R:I47	1.76	No	No	0	7	8
255	R:R:A76	R:R:V54	1.7	No	No	0	9	9
256	R:R:C77	R:R:T73	1.69	No	No	0	6	6
257	R:R:E188	R:R:G102	1.64	No	No	0	3	7
258	R:R:C285	R:R:I314	1.64	No	No	0	9	7
259	R:R:L324	R:R:P323	1.64	No	No	0	6	9
260	R:R:A92	R:R:M96	1.61	No	No	0	4	4
261	R:R:V126	R:R:V157	1.6	No	No	0	7	7
262	R:R:T56	R:R:V52	1.59	No	No	0	5	3
263	R:R:T164	R:R:V160	1.59	No	No	0	5	4
264	R:R:A57	R:R:L339	1.58	No	No	0	8	6
265	R:R:C190	R:R:N187	1.57	No	No	0	3	4
266	R:R:I43	R:R:V39	1.54	No	No	0	6	5
267	R:R:I205	R:R:V210	1.54	No	No	0	4	5
268	R:R:K147	R:R:V67	1.52	No	No	0	1	6
269	R:R:M156	R:R:V160	1.52	No	No	0	4	4
270	R:R:F49	R:R:G50	1.51	No	No	0	4	8
271	R:R:F101	R:R:G102	1.51	Yes	No	0	5	7
272	R:R:L275	R:R:T274	1.47	No	No	0	8	8
273	R:R:D331	R:R:S329	1.47	No	No	0	7	8
274	R:R:N148	R:R:T146	1.46	No	No	0	4	8
275	R:R:I277	R:R:K273	1.45	No	No	0	7	7
276	R:R:E237	R:R:S236	1.44	No	No	0	3	4
277	R:R:P330	R:R:R333	1.44	No	No	0	5	9
278	R:R:E30	R:R:V33	1.43	No	No	0	3	4
279	R:R:I159	R:R:L163	1.43	No	No	0	4	4
280	R:R:K149	R:R:L145	1.41	No	No	0	5	7
281	R:R:E188	R:R:T189	1.41	No	No	0	3	4
282	R:R:I182	R:R:Q179	1.37	No	No	0	1	3
283	R:R:I334	R:R:Q337	1.37	No	No	0	4	4
284	R:R:H269	R:R:K273	1.31	No	No	0	5	7
285	R:R:R304	R:R:V307	1.31	No	No	0	4	4
286	R:R:F321	R:R:V317	1.31	No	No	0	6	5
287	R:R:F101	R:R:T100	1.3	Yes	No	0	5	2
288	R:R:I334	R:R:R63	1.25	No	No	0	4	6
289	R:R:F61	R:R:K60	1.24	No	No	0	6	5
290	R:R:V33	R:R:W32	1.23	No	No	0	4	3
291	R:R:F240	R:R:H241	1.13	No	No	0	4	3
292	R:R:F240	R:R:R239	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.22556	9	1	0
2	R:R:M40	6.464	5	1	6
3	R:R:N51	4.9025	4	0	9
4	R:R:N69	5.075	4	4	9
5	R:R:F71	5.558	5	0	8
6	R:R:L75	6.434	5	3	9
7	R:R:D79	7.778	5	3	9
8	R:R:L80	3.9075	4	6	7
9	R:R:V87	3.525	4	1	7
10	R:R:W99	6.678	5	5	7
11	R:R:F101	3.612	5	0	5
12	R:R:W109	3.255	4	0	5
13	R:R:Y132	6.416	5	0	8
14	R:R:W158	5.2775	4	0	9
15	R:R:S165	4.095	4	0	7
16	R:R:F166	5.466	5	2	4
17	R:R:Y174	7.125	4	2	5
18	R:R:F193	5.855	4	0	4
19	R:R:F194	5.97	6	2	1
20	R:R:Y199	4.50167	6	2	6
21	R:R:F208	8.34667	6	1	8
22	R:R:P211	6.05	4	0	8
23	R:R:M215	3.66	4	0	8
24	R:R:Y219	4.472	5	7	9
25	R:R:R221	3.3225	4	0	5
26	R:R:F223	4.9875	4	0	6
27	R:R:F282	4.6625	4	1	9
28	R:R:W286	5.36333	6	1	8
29	R:R:F289	7.52	6	1	6
30	R:R:F290	8.048	5	1	7
31	R:R:N293	5.2375	4	1	5
32	R:R:I303	3.556	5	0	3
33	R:R:Y308	7.1775	4	1	5
34	R:R:W313	6.69	4	1	5
35	R:R:Y316	6.898	5	1	6
36	R:R:N318	3.4375	4	0	9
37	R:R:Y326	3.706	5	0	9
38	R:R:F332	7.3	6	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y316	60.9096	5.45	Yes	Yes	1	0	6
2	R:R:W313	R:R:Y316	27.8334	6.75	Yes	Yes	1	5	6
3	R:R:M40	R:R:W313	15.3512	11.63	Yes	Yes	1	6	5
4	L:L:?1	R:R:V117	57.2831	11.09	Yes	No	0	0	6
5	R:R:M82	R:R:V117	20.0252	3.04	No	No	0	7	6
6	R:R:M82	R:R:S319	19.0406	6.13	No	No	0	7	9
7	R:R:D79	R:R:S319	18.871	10.31	Yes	No	0	9	9
8	R:R:D79	R:R:N51	13.7594	10.77	Yes	Yes	0	9	9
9	R:R:D79	R:R:L75	18.8792	8.14	Yes	Yes	3	9	9
10	R:R:L124	R:R:L75	50.9572	4.15	No	Yes	0	8	9
11	R:R:L124	R:R:Y326	98.2633	3.52	No	Yes	0	8	9
12	R:R:I72	R:R:Y326	73.8404	2.42	No	Yes	0	8	9
13	R:R:C327	R:R:I72	71.1766	3.27	No	No	0	7	8
14	R:R:V117	R:R:W286	38.9755	4.9	No	Yes	0	6	8
15	R:R:N318	R:R:W286	39.9136	3.39	Yes	Yes	0	9	8
16	R:R:N318	R:R:N322	36.7	2.72	Yes	No	0	9	9
17	R:R:L75	R:R:N322	34.0882	10.98	Yes	No	3	9	9
18	L:L:?1	R:R:F289	70.2795	9.06	Yes	Yes	1	0	6
19	R:R:F289	R:R:W286	65.6465	7.02	Yes	Yes	1	6	8
20	R:R:F208	R:R:W286	65.7532	3.01	Yes	Yes	1	8	8
21	R:R:F208	R:R:F282	100	7.5	Yes	Yes	1	8	9
22	R:R:F282	R:R:M215	91.1169	3.73	Yes	Yes	0	9	8
23	R:R:L124	R:R:M215	59.7391	2.83	No	Yes	0	8	8
24	R:R:F289	R:R:F290	40.693	7.5	Yes	Yes	1	6	7
25	R:R:F208	R:R:F290	40.6082	20.36	Yes	Yes	1	8	7
26	R:R:C327	R:R:F332	60.4666	13.97	No	Yes	0	7	9
27	R:R:F332	R:R:F336	30.5628	7.5	Yes	No	0	9	7
28	R:R:A57	R:R:F336	27.8115	2.77	No	No	0	8	7
29	R:R:A335	R:R:A57	19.5247	1.79	No	No	0	7	8
30	R:R:A335	R:R:F61	16.7514	5.55	No	No	0	7	6
31	R:R:E338	R:R:F61	11.1886	5.83	No	No	0	4	6
32	L:L:?1	R:R:V114	20.5257	4.16	Yes	No	0	0	5
33	R:R:S165	R:R:V114	19.366	3.23	Yes	No	0	7	5
34	R:R:L115	R:R:S165	16.9073	6.01	No	Yes	0	5	7
35	R:R:L115	R:R:W158	16.6092	4.56	No	Yes	0	5	9
36	R:R:S74	R:R:W158	16.2975	6.18	No	Yes	0	9	9
37	R:R:I154	R:R:S74	14.2982	6.19	No	No	0	8	9
38	R:R:F71	R:R:I154	13.7376	5.02	Yes	No	0	8	8
39	R:R:D130	R:R:F71	14.2955	8.36	No	Yes	0	8	8
40	R:R:D130	R:R:Y141	12.0009	8.05	No	No	0	8	7
41	R:R:F71	R:R:I127	10.896	3.77	Yes	No	0	8	9
42	R:R:I127	R:R:Y326	13.0566	3.63	No	Yes	0	9	9
43	L:L:?1	R:R:D113	42.5528	12.62	Yes	No	1	0	7
44	R:R:D113	R:R:V86	41.2838	11.69	No	No	1	7	7
45	R:R:V86	R:R:Y316	60.9616	3.79	No	Yes	1	7	6
46	R:R:V86	R:R:W109	98.9689	2.45	No	Yes	0	7	5
47	R:R:F89	R:R:W109	41.0978	4.01	No	Yes	0	5	5
48	R:R:F101	R:R:F89	37.7038	3.22	Yes	No	0	5	5
49	R:R:W109	R:R:W99	51.3155	3.75	Yes	Yes	0	5	7
50	R:R:F101	R:R:W99	37.794	5.01	Yes	Yes	0	5	7
51	R:R:F289	R:R:Y308	26.3811	8.25	Yes	Yes	1	6	5
52	R:R:F101	R:R:T100	20.6487	1.3	Yes	No	0	5	2
53	R:R:M96	R:R:T100	13.7704	4.52	No	No	0	4	2
54	R:R:F101	R:R:G102	34.389	1.51	Yes	No	0	5	7
55	R:R:E188	R:R:G102	27.5216	1.64	No	No	0	3	7
56	R:R:E188	R:R:T189	13.7704	1.41	No	No	0	3	4
57	R:R:F101	R:R:W105	13.7704	7.02	Yes	No	0	5	5
58	L:L:?1	R:R:F193	30.4206	4.53	Yes	Yes	0	0	4
59	R:R:F193	R:R:Y174	26.2116	7.22	Yes	Yes	0	4	5
60	R:R:E107	R:R:Y174	24.5214	2.24	No	Yes	2	5	5
61	R:R:E107	R:R:R175	21.327	3.49	No	No	2	5	2
62	L:L:?1	R:R:S203	14.1095	2.79	Yes	No	0	0	5
63	R:R:S203	R:R:Y199	12.6819	6.36	No	Yes	0	5	6
64	R:R:A128	R:R:M215	45.7937	3.22	No	Yes	0	8	8
65	R:R:A128	R:R:Y219	44.1637	6.67	No	Yes	0	8	9
66	R:R:V218	R:R:Y219	26.0065	2.52	No	Yes	0	6	9
67	R:R:V218	R:R:Y132	24.3108	8.83	No	Yes	0	6	8
68	R:R:R221	R:R:Y132	15.7505	3.09	Yes	Yes	0	5	8
69	R:R:R175	R:R:Y185	19.7544	17.49	No	No	2	2	1
70	R:R:F194	R:R:Y185	13.1906	4.13	Yes	No	2	1	1
71	R:R:H296	R:R:Y308	29.7068	9.8	No	Yes	0	3	5
72	R:R:L275	R:R:Y219	13.888	2.34	No	Yes	0	8	9
73	R:R:F223	R:R:L275	10.4146	3.65	Yes	No	0	6	8
74	R:R:I325	R:R:Y326	13.9728	4.84	No	Yes	0	8	9
75	R:R:I277	R:R:I325	11.1886	2.94	No	No	0	7	8
76	R:R:H296	R:R:I303	21.1328	2.65	No	Yes	0	3	3
77	R:R:F332	R:R:S329	11.1886	3.96	Yes	No	0	9	8
78	R:R:N312	R:R:Y316	27.1415	9.3	No	Yes	1	5	6
79	R:R:F289	R:R:N312	27.6966	9.67	Yes	No	1	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D113	12.62	1	Yes	No	0	7	0	1
L:L:?1	R:R:V114	4.16	1	Yes	No	0	5	0	1
L:L:?1	R:R:V117	11.09	1	Yes	No	0	6	0	1
L:L:?1	R:R:F193	4.53	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S203	2.79	1	Yes	No	0	5	0	1
L:L:?1	R:R:F289	9.06	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N293	6.39	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N312	8.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y316	5.45	1	Yes	Yes	0	6	0	1
R:R:M82	R:R:V117	3.04	0	No	No	7	6	2	1
R:R:D113	R:R:V86	11.69	1	No	No	7	7	1	2
R:R:V86	R:R:Y316	3.79	1	No	Yes	7	6	2	1
R:R:F193	R:R:T110	3.89	0	Yes	No	4	4	1	2
R:R:D113	R:R:Y316	9.2	1	No	Yes	7	6	1	1
R:R:S165	R:R:V114	3.23	0	Yes	No	7	5	2	1
R:R:V117	R:R:W286	4.9	0	No	Yes	6	8	1	2
R:R:F193	R:R:Y174	7.22	0	Yes	Yes	4	5	1	2
R:R:Y174	R:R:Y199	6.95	2	Yes	Yes	5	6	2	2
R:R:F193	R:R:T195	7.78	0	Yes	No	4	3	1	2
R:R:T195	R:R:Y199	3.75	0	No	Yes	3	6	2	2
R:R:S203	R:R:Y199	6.36	0	No	Yes	5	6	1	2
R:R:F290	R:R:S204	5.28	1	Yes	No	7	5	2	2
R:R:N293	R:R:S204	7.45	1	Yes	No	5	5	1	2
R:R:F289	R:R:W286	7.02	1	Yes	Yes	6	8	1	2
R:R:F290	R:R:W286	4.01	1	Yes	Yes	7	8	2	2
R:R:F289	R:R:F290	7.5	1	Yes	Yes	6	7	1	2
R:R:F289	R:R:N293	3.62	1	Yes	Yes	6	5	1	1
R:R:F289	R:R:Y308	8.25	1	Yes	Yes	6	5	1	2
R:R:F289	R:R:N312	9.67	1	Yes	No	6	5	1	1
R:R:N293	R:R:Y308	3.49	1	Yes	Yes	5	5	1	2
R:R:N312	R:R:Y316	9.3	1	No	Yes	5	6	1	1
R:R:W313	R:R:Y316	6.75	1	Yes	Yes	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9U9V_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.65
Number of Linked Nodes	261
Number of Links	292
Number of Hubs	38
Number of Links mediated by Hubs	154
Number of Communities	8
Number of Nodes involved in Communities	56
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	88610
Length Of Smallest Path	3
Average Path Length	14.1258
Length of Longest Path	27
Minimum Path Strength	1.1
Average Path Strength	5.61637
Maximum Path Strength	18.9
Minimum Path Correlation	0.7
Average Path Correlation	0.941557
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	54.4932
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.2938
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • amyloid-beta binding • binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • multicellular organismal process • response to nutrient levels • multicellular organismal-level homeostasis • response to stimulus • homeostatic process • response to dietary excess • diet induced thermogenesis • temperature homeostasis • energy homeostasis • adaptive thermogenesis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • bone mineralization • animal organ development • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • negative regulation of cardiac muscle cell apoptotic process • muscle cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • cardiac muscle cell apoptotic process • negative regulation of apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • negative regulation of muscle cell apoptotic process • negative regulation of cellular process • negative regulation of striated muscle cell apoptotic process • apoptotic process • programmed cell death • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • heart process • regulation of actin filament-based process • regulation of heart contraction • cardiac muscle contraction • striated muscle contraction • circulatory system process • actin filament-based process • positive regulation of actin filament-based movement • blood circulation • cardiac muscle cell contraction • regulation of cardiac muscle contraction • positive regulation of cardiac muscle cell contraction • actin filament-based movement • regulation of blood circulation • regulation of striated muscle contraction • regulation of actin filament-based movement • regulation of cardiac muscle cell contraction • actin-mediated cell contraction • heart contraction • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • cellular component organization • autophagosome maturation • cellular component organization or biogenesis • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • positive regulation of cardiac muscle cell apoptotic process • positive regulation of programmed cell death • positive regulation of striated muscle cell apoptotic process • positive regulation of apoptotic process • positive regulation of muscle cell apoptotic process • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • apical part of cell • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • skeletal muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of skeletal muscle contraction • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	B40
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	B40
Name	Metamfetamine
Synonyms	Dextromethamphetamine
Identifier
Formula	C10 H15 N
Molecular Weight	149.233
SMILES
PubChem	10836
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>9U9V_nogp_Chain_R E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K M W T F G N F W C E F W T S I D V L C V T A S I T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S F L P I Q M H W Y R A T H Q E A I N C Y A N E T C C D F F T N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E G R F H E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q D N L I R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E L L W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	2R4R	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	2R4S	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	doi.org/10.1016/j.str.2008.05.001
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	doi.org/10.1038/nature08650
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 913103	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.16	2010-08-11	doi.org/10.1021/ja105108q
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	FAUC50	-	-	3.5	2011-01-12	doi.org/10.1038/nature09665
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	doi.org/10.1038/nature09648
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	doi.org/10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	doi.org/10.1038/nature10361
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.99	2012-10-24	doi.org/10.1371/journal.pone.0046039
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	doi.org/10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzyl Isoproterenol	-	-	3.1	2013-09-25	doi.org/10.1038/nature12572
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	Epinephrine	-	-	3.2	2013-09-25	doi.org/10.1038/nature12572
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 76210628	-	-	3.3	2014-07-23	doi.org/10.1073/pnas.1410415111
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	2.48	2016-01-13	doi.org/10.1107/S2059798315021683
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.8	2016-01-13	doi.org/10.1107/S2059798315021683
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.2	2016-07-13	doi.org/10.1038/nature18636
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.2	2016-08-17	doi.org/10.1038/nprot.2017.057
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	PubChem 129318963	-	2.7	2017-08-16	doi.org/10.1038/nature23652
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	doi.org/10.1038/s41589-018-0145-x
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	doi.org/10.1126/science.aaw8981
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	2.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	Carvedilol	-	-	2.5	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	Propranolol	-	-	2.9	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	doi.org/10.1107/S2052252519013137
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	GTPL11074	-	3.1	2020-03-25	doi.org/10.1038/s41589-020-0549-2
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8GE2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ1	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ1	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Norepinephrine	-	-	3.49	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHV	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.95	2024-11-13	doi.org/10.1073/pnas.2414544121
	9U9V	A	Amine	Adrenergic	β₂	Homo sapiens	METH	-	Gs/β1/γ2	2.85	2025-09-03	To be published
	9U9V (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	METH	-		2.85	2025-09-03	To be published
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.5	2024-11-13	doi.org/10.1073/pnas.2414544121
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9M55	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	DPMF	-	chim(NtGi1-Gs)/β1/γ2	3.39	2025-12-17	10.1093/pnasnexus/pgaf376
	9M55 (No Gprot)	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	DPMF	-		3.39	2025-12-17	10.1093/pnasnexus/pgaf376
	9M57	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	Octopamine	-	chim(NtGi1-Gs)/β1/γ2	3.65	2025-12-17	10.1093/pnasnexus/pgaf376
	9M57 (No Gprot)	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	Octopamine	-		3.65	2025-12-17	10.1093/pnasnexus/pgaf376
	9L8L	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	Atazanavir	Gs/β1/γ2 ; Arrestin2	3.22	2025-12-31	To be published
	9L8L (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	Atazanavir		3.22	2025-12-31	To be published

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