psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I43	R:R:M40	4.37	No	No	0	6	6
2	R:R:I47	R:R:V44	6.14	Yes	No	3	8	6
3	R:R:V44	R:R:V87	8.02	No	Yes	3	6	7
4	R:R:G83	R:R:I47	3.53	No	Yes	3	7	8
5	R:R:I47	R:R:V87	4.61	Yes	Yes	3	8	7
6	R:R:I47	R:R:S319	6.19	Yes	No	0	8	9
7	R:R:L84	R:R:V48	13.41	No	No	0	5	6
8	R:R:G50	R:R:P323	4.06	No	Yes	0	8	9
9	R:R:D79	R:R:N51	12.12	No	No	0	9	9
10	R:R:N51	R:R:P323	3.26	No	Yes	0	9	9
11	R:R:I55	R:R:V52	7.68	No	No	0	7	3
12	R:R:L80	R:R:V52	4.47	No	No	0	7	3
13	R:R:F332	R:R:V54	6.55	Yes	No	0	9	9
14	R:R:A57	R:R:F332	4.16	No	Yes	0	8	9
15	R:R:I58	R:R:T73	10.64	No	No	0	7	6
16	R:R:E62	R:R:Q65	5.1	No	No	0	6	8
17	R:R:F332	R:R:L64	7.31	Yes	No	2	9	8
18	R:R:A335	R:R:L64	4.73	No	No	2	7	8
19	R:R:N69	R:R:T66	5.85	No	No	0	9	7
20	R:R:F71	R:R:V67	3.93	Yes	No	1	8	6
21	R:R:D130	R:R:V67	5.84	Yes	No	1	8	6
22	R:R:L145	R:R:V67	2.98	Yes	No	1	7	6
23	R:R:R131	R:R:T68	10.35	Yes	No	0	9	8
24	R:R:L275	R:R:T68	4.42	No	No	0	8	8
25	R:R:I72	R:R:N69	4.25	No	No	0	8	9
26	R:R:K147	R:R:Y70	5.97	No	Yes	0	1	4
27	R:R:R151	R:R:Y70	14.4	No	Yes	0	3	4
28	R:R:F71	R:R:V126	6.55	Yes	No	1	8	7
29	R:R:F71	R:R:I127	8.79	Yes	Yes	1	8	9
30	R:R:F71	R:R:I154	10.05	Yes	No	0	8	8
31	R:R:I278	R:R:I72	2.94	No	No	0	8	8
32	R:R:I72	R:R:Y326	10.88	No	Yes	0	8	9
33	R:R:L75	R:R:S74	3	No	No	1	9	9
34	R:R:S74	R:R:T123	3.2	No	Yes	1	9	8
35	R:R:L75	R:R:T123	4.42	No	Yes	1	9	8
36	R:R:D79	R:R:S319	7.36	No	No	0	9	9
37	R:R:I112	R:R:V81	4.61	No	No	0	4	7
38	R:R:M82	R:R:V86	7.61	No	No	0	7	7
39	R:R:C116	R:R:M82	8.1	No	No	0	7	7
40	R:R:G83	R:R:V87	3.68	No	Yes	3	7	7
41	R:R:I112	R:R:V86	3.07	No	No	0	4	7
42	R:R:D113	R:R:V86	2.92	No	No	0	7	7
43	R:R:P88	R:R:V87	3.53	No	Yes	0	8	7
44	R:R:F108	R:R:S111	3.96	No	No	0	5	6
45	R:R:T110	R:R:W109	6.06	No	No	0	4	5
46	R:R:C116	R:R:I112	4.91	No	No	0	7	4
47	R:R:T118	R:R:V114	6.35	Yes	No	0	6	5
48	R:R:L115	R:R:S161	4.5	No	No	0	5	8
49	R:R:V117	R:R:W286	13.48	No	Yes	0	6	8
50	R:R:S161	R:R:T118	4.8	No	Yes	0	8	6
51	R:R:T118	R:R:T164	3.14	Yes	No	0	6	5
52	R:R:S207	R:R:T118	7.99	No	Yes	0	5	6
53	R:R:A119	R:R:S161	3.42	No	No	0	7	8
54	R:R:F282	R:R:S120	6.61	Yes	No	0	9	9
55	R:R:I121	R:R:P211	6.77	No	No	0	7	8
56	R:R:I121	R:R:L212	4.28	No	No	0	7	7
57	R:R:F282	R:R:I121	5.02	Yes	No	0	9	7
58	R:R:E122	R:R:V157	2.85	No	No	0	5	7
59	R:R:I127	R:R:T123	3.04	Yes	Yes	1	9	8
60	R:R:L124	R:R:M215	5.65	No	No	1	8	8
61	R:R:L124	R:R:M279	4.24	No	No	1	8	8
62	R:R:C125	R:R:I214	3.27	No	No	0	7	6
63	R:R:C125	R:R:M215	3.24	No	No	0	7	8
64	R:R:I127	R:R:V126	3.07	Yes	No	1	9	7
65	R:R:I127	R:R:R131	3.76	Yes	Yes	1	9	9
66	R:R:V129	R:R:V218	6.41	No	No	0	6	6
67	R:R:D130	R:R:R131	9.53	Yes	Yes	1	8	9
68	R:R:D130	R:R:S143	11.78	Yes	No	1	8	4
69	R:R:D130	R:R:L145	4.07	Yes	Yes	1	8	7
70	R:R:R131	R:R:Y141	8.23	Yes	Yes	1	9	7
71	R:R:Q142	R:R:R131	5.84	No	Yes	0	4	9
72	R:R:L272	R:R:R131	3.64	No	Yes	1	7	9
73	R:R:F133	R:R:Y132	3.09	No	Yes	0	5	8
74	R:R:T136	R:R:Y132	13.73	No	Yes	0	7	8
75	R:R:R221	R:R:Y132	10.29	No	Yes	0	5	8
76	R:R:V222	R:R:Y132	5.05	No	Yes	0	8	8
77	R:R:I135	R:R:Y141	4.84	No	Yes	0	9	7
78	R:R:P138	R:R:S137	5.34	No	No	0	8	6
79	R:R:F139	R:R:K140	27.3	No	No	0	6	5
80	R:R:F264	R:R:Y141	4.13	Yes	Yes	1	4	7
81	R:R:L272	R:R:Y141	8.21	No	Yes	1	7	7
82	R:R:L145	R:R:S143	4.5	Yes	No	1	7	4
83	R:R:I153	R:R:L145	2.85	No	Yes	0	6	7
84	R:R:N148	R:R:T146	8.77	No	No	4	4	8
85	R:R:K149	R:R:T146	13.51	No	No	4	5	8
86	R:R:K149	R:R:N148	5.6	No	No	4	5	4
87	R:R:I153	R:R:I154	2.94	No	No	0	6	8
88	R:R:I159	R:R:M156	5.83	No	No	0	4	4
89	R:R:M156	R:R:V160	3.04	No	No	0	4	4
90	R:R:I205	R:R:Y209	8.46	No	No	0	4	5
91	R:R:F208	R:R:Y209	4.13	No	No	0	8	5
92	R:R:F208	R:R:L287	3.65	No	Yes	0	8	6
93	R:R:F208	R:R:F290	27.86	No	Yes	0	8	7
94	R:R:V213	R:R:Y209	8.83	No	No	0	4	5
95	R:R:P211	R:R:V210	3.53	No	No	0	8	5
96	R:R:L212	R:R:V216	2.98	No	No	0	7	5
97	R:R:M215	R:R:M279	5.78	No	No	1	8	8
98	R:R:F217	R:R:V216	5.24	No	No	0	4	5
99	R:R:F223	R:R:Y219	6.19	No	Yes	0	6	9
100	R:R:G276	R:R:Y219	4.35	No	Yes	0	6	9
101	R:R:M279	R:R:Y219	9.58	No	Yes	0	8	9
102	R:R:K227	R:R:L230	4.23	No	No	1	6	5
103	R:R:H269	R:R:K227	10.48	Yes	No	1	5	6
104	R:R:F264	R:R:Q229	12.88	Yes	No	0	4	7
105	R:R:F264	R:R:L230	6.09	Yes	No	1	4	5
106	R:R:H269	R:R:L230	20.57	Yes	No	1	5	5
107	R:R:K235	R:R:Q231	13.56	No	No	0	5	5
108	R:R:D234	R:R:S236	8.83	No	No	0	4	4
109	R:R:K235	R:R:R239	3.71	No	No	0	5	4
110	R:R:E237	R:R:H241	9.85	Yes	No	0	3	3
111	R:R:F240	R:R:R239	6.41	No	No	0	4	4
112	R:R:F264	R:R:H269	7.92	Yes	Yes	1	4	5
113	R:R:H269	R:R:L266	3.86	Yes	No	0	5	5
114	R:R:E268	R:R:K267	5.4	No	No	0	7	6
115	R:R:K270	R:R:K273	5.75	No	No	0	7	7
116	R:R:K273	R:R:S329	4.59	No	No	0	7	8
117	R:R:T274	R:R:Y326	7.49	Yes	Yes	2	8	9
118	R:R:S329	R:R:T274	3.2	No	Yes	2	8	8
119	R:R:P330	R:R:T274	12.24	No	Yes	2	5	8
120	R:R:I278	R:R:L275	2.85	No	No	0	8	8
121	R:R:I277	R:R:I325	10.3	No	No	0	7	8
122	R:R:I278	R:R:N322	7.08	No	No	0	8	9
123	R:R:N318	R:R:T281	5.85	Yes	No	0	9	6
124	R:R:F321	R:R:T281	3.89	No	No	0	6	6
125	R:R:F282	R:R:W286	10.02	Yes	Yes	0	9	8
126	R:R:F282	R:R:N318	10.87	Yes	Yes	0	9	9
127	R:R:L284	R:R:T283	7.37	No	No	0	5	7
128	R:R:L287	R:R:T283	2.95	Yes	No	0	6	7
129	R:R:C285	R:R:N318	3.15	No	Yes	0	9	9
130	R:R:F290	R:R:W286	7.02	Yes	Yes	0	7	8
131	R:R:G315	R:R:W286	9.85	No	Yes	0	7	8
132	R:R:L287	R:R:P288	3.28	Yes	No	0	6	9
133	R:R:I291	R:R:L287	5.71	No	Yes	0	6	6
134	R:R:F289	R:R:F290	8.57	No	Yes	0	6	7
135	R:R:F289	R:R:N312	12.08	No	No	0	6	5
136	R:R:I314	R:R:L311	5.71	No	No	0	7	5
137	R:R:N312	R:R:Y316	6.98	No	No	0	5	6
138	R:R:I314	R:R:W313	9.4	No	No	0	7	5
139	R:R:N318	R:R:N322	12.26	Yes	No	0	9	9
140	R:R:G320	R:R:P323	4.06	No	Yes	0	7	9
141	R:R:F321	R:R:L324	7.31	No	No	0	6	6
142	R:R:N322	R:R:P323	3.26	No	Yes	0	9	9
143	R:R:I325	R:R:L324	4.28	No	No	0	8	6
144	R:R:P330	R:R:Y326	23.64	No	Yes	2	5	9
145	R:R:F332	R:R:Y326	14.44	Yes	Yes	2	9	9
146	R:R:P330	R:R:S329	5.34	No	No	2	5	8
147	R:R:A335	R:R:F332	4.16	No	Yes	2	7	9
148	R:R:F332	R:R:F336	11.79	Yes	Yes	2	9	7
149	R:R:Q337	R:R:R333	11.68	No	No	0	4	9
150	R:R:E338	R:R:I334	16.4	No	No	0	4	4
151	R:R:Q337	R:R:R343	12.85	No	No	0	4	6
152	R:R:E338	R:R:L342	5.3	No	No	0	4	8
153	R:R:L339	R:R:L340	5.54	Yes	No	2	6	6
154	R:R:L342	R:R:S346	10.51	No	No	0	8	2
155	R:R:R343	R:R:R344	8.53	No	No	0	6	4
156	R:R:K348	R:R:R344	7.43	No	No	0	3	4
157	R:R:C327	R:R:F336	2.79	No	Yes	0	7	7
158	R:R:L339	R:R:L53	2.77	Yes	No	2	6	6
159	R:R:L340	R:R:L53	2.77	No	No	2	6	6
160	R:R:A150	R:R:F71	2.77	No	Yes	0	7	8
161	R:R:L124	R:R:L75	2.77	No	No	1	8	9
162	R:R:L80	R:R:L84	2.77	No	No	0	7	5
163	R:R:A134	R:R:R131	2.77	No	Yes	0	8	9
164	R:R:A226	R:R:F264	2.77	No	Yes	0	8	4
165	R:R:K147	R:R:Q65	2.71	No	No	0	1	8
166	R:R:F290	R:R:S204	2.64	Yes	No	0	7	5
167	R:R:F240	R:R:S236	2.64	No	No	0	4	4
168	R:R:F133	R:R:V129	2.62	No	No	0	5	6
169	R:R:F321	R:R:V317	2.62	No	No	0	6	5
170	R:R:D234	R:R:E237	2.6	No	Yes	0	4	3
171	R:R:V222	R:R:Y219	2.52	No	Yes	0	8	9
172	R:R:F336	R:R:L53	2.44	Yes	No	2	7	6
173	R:R:F336	R:R:L339	2.44	Yes	Yes	2	7	6
174	R:R:M82	R:R:Y316	2.39	No	No	0	7	6
175	R:R:F223	R:R:Q224	2.34	No	No	0	6	3
176	R:R:F336	R:R:Q337	2.34	Yes	No	0	7	4
177	R:R:M40	R:R:W313	2.33	No	No	0	6	5
178	R:R:E268	R:R:F264	2.33	No	Yes	0	7	4
179	R:R:R328	R:R:R333	2.13	No	No	0	7	9
180	R:R:F71	R:R:Y70	2.06	Yes	Yes	0	8	4
181	R:R:G280	R:R:T283	1.82	No	No	0	5	7
182	R:R:G315	R:R:I314	1.76	No	No	0	7	7
183	R:R:G37	R:R:M40	1.75	No	No	0	5	6
184	R:R:C77	R:R:V81	1.71	No	No	0	6	7
185	R:R:A78	R:R:S120	1.71	No	No	0	8	9
186	R:R:G162	R:R:L115	1.71	No	No	0	4	5
187	R:R:A85	R:R:V81	1.7	No	No	0	4	7
188	R:R:A128	R:R:V218	1.7	No	No	0	8	6
189	R:R:A271	R:R:T274	1.68	No	Yes	0	8	8
190	R:R:E237	R:R:G238	1.64	Yes	No	0	3	4
191	R:R:S203	R:R:S207	1.63	No	No	0	5	5
192	R:R:A76	R:R:I55	1.62	No	No	0	9	7
193	R:R:A59	R:R:I58	1.62	No	No	0	4	7
194	R:R:S203	R:R:V206	1.62	No	No	0	5	4
195	R:R:C265	R:R:K267	1.62	No	No	0	3	6
196	R:R:V44	R:R:V48	1.6	No	No	0	6	6
197	R:R:T123	R:R:V157	1.59	Yes	No	0	8	7
198	R:R:A335	R:R:D331	1.54	No	No	0	7	7
199	R:R:F49	R:R:G50	1.51	No	No	0	4	8
200	R:R:L144	R:R:S137	1.5	No	No	0	4	6
201	R:R:L339	R:R:T56	1.47	Yes	No	0	6	5
202	R:R:F89	R:R:P88	1.44	No	No	0	5	8
203	R:R:Q224	R:R:S220	1.44	No	No	0	3	3
204	R:R:E122	R:R:V160	1.43	No	No	0	5	4
205	R:R:I233	R:R:Q231	1.37	No	No	0	6	5
206	R:R:E237	R:R:I233	1.37	Yes	No	0	3	6
207	R:R:F139	R:R:S137	1.32	No	No	0	6	6
208	R:R:C77	R:R:W158	1.31	No	No	0	6	9
209	R:R:F49	R:R:L45	1.22	No	No	0	4	5
210	R:R:F61	R:R:L64	1.22	No	No	0	6	8
211	R:R:F61	R:R:L339	1.22	No	Yes	0	6	6
212	R:R:I58	R:R:Y70	1.21	No	Yes	0	7	4
213	R:R:E225	R:R:R221	1.16	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I47	5.1175	4	3	8
2	R:R:Y70	5.91	4	0	4
3	R:R:F71	5.69167	6	1	8
4	R:R:V87	4.96	4	3	7
5	R:R:T118	5.57	4	0	6
6	R:R:T123	3.0625	4	1	8
7	R:R:I127	4.665	4	1	9
8	R:R:D130	7.805	4	1	8
9	R:R:R131	6.30286	7	1	9
10	R:R:Y132	8.04	4	0	8
11	R:R:Y141	6.3525	4	1	7
12	R:R:L145	3.6	4	1	7
13	R:R:Y219	5.66	4	0	9
14	R:R:E237	3.865	4	0	3
15	R:R:F264	6.02	6	1	4
16	R:R:H269	10.7075	4	1	5
17	R:R:T274	6.1525	4	2	8
18	R:R:F282	8.13	4	0	9
19	R:R:W286	10.0925	4	0	8
20	R:R:L287	3.8975	4	0	6
21	R:R:F290	11.5225	4	0	7
22	R:R:N318	8.0325	4	0	9
23	R:R:P323	3.66	4	0	9
24	R:R:Y326	14.1125	4	2	9
25	R:R:F332	8.06833	6	2	9
26	R:R:F336	4.36	5	2	7
27	R:R:L339	2.688	5	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G315	R:R:I314	13.4475	1.76	No	No	0	7	7
2	R:R:G315	R:R:W286	15.6191	9.85	No	Yes	0	7	8
3	R:R:F282	R:R:W286	69.2743	10.02	Yes	Yes	0	9	8
4	R:R:F282	R:R:N318	80.0513	10.87	Yes	Yes	0	9	9
5	R:R:N318	R:R:N322	87.8203	12.26	Yes	No	0	9	9
6	R:R:N322	R:R:P323	41.5295	3.26	No	Yes	0	9	9
7	R:R:N51	R:R:P323	32.1554	3.26	No	Yes	0	9	9
8	R:R:D79	R:R:N51	30.1996	12.12	No	No	0	9	9
9	R:R:D79	R:R:S319	28.2169	7.36	No	No	0	9	9
10	R:R:I47	R:R:S319	26.2072	6.19	Yes	No	0	8	9
11	R:R:I47	R:R:V44	15.4707	6.14	Yes	No	3	8	6
12	R:R:V44	R:R:V48	13.6633	1.6	No	No	0	6	6
13	R:R:L84	R:R:V48	11.4513	13.41	No	No	0	5	6
14	R:R:F332	R:R:Y326	41.3947	14.44	Yes	Yes	2	9	9
15	R:R:I72	R:R:Y326	58.1198	10.88	No	Yes	0	8	9
16	R:R:I278	R:R:I72	62.5034	2.94	No	No	0	8	8
17	R:R:I278	R:R:N322	100	7.08	No	No	0	8	9
18	R:R:I278	R:R:L275	94.6857	2.85	No	No	0	8	8
19	R:R:L275	R:R:T68	94.0518	4.42	No	No	0	8	8
20	R:R:R131	R:R:T68	93.3909	10.35	Yes	No	0	9	8
21	R:R:I127	R:R:R131	70.4883	3.76	Yes	Yes	1	9	9
22	R:R:F71	R:R:I127	24.3189	8.79	Yes	Yes	1	8	9
23	R:R:F71	R:R:Y70	18.0065	2.06	Yes	Yes	0	8	4
24	R:R:I127	R:R:T123	53.7227	3.04	Yes	Yes	1	9	8
25	R:R:L75	R:R:T123	41.4351	4.42	No	Yes	1	9	8
26	R:R:I112	R:R:V86	10.8848	3.07	No	No	0	4	7
27	R:R:M82	R:R:V86	15.0931	7.61	No	No	0	7	7
28	R:R:M82	R:R:Y316	29.8354	2.39	No	No	0	7	6
29	R:R:N312	R:R:Y316	31.8182	6.98	No	No	0	5	6
30	R:R:F289	R:R:N312	33.747	12.08	No	No	0	6	5
31	R:R:F289	R:R:F290	35.6488	8.57	No	Yes	0	6	7
32	R:R:F290	R:R:W286	56.3663	7.02	Yes	Yes	0	7	8
33	R:R:C116	R:R:I112	10.8309	4.91	No	No	0	7	4
34	R:R:C116	R:R:M82	12.935	8.1	No	No	0	7	7
35	R:R:I112	R:R:V81	17.3456	4.61	No	No	0	4	7
36	R:R:F282	R:R:I121	13.434	5.02	Yes	No	0	9	7
37	R:R:T123	R:R:V157	11.3164	1.59	Yes	No	0	8	7
38	R:R:L124	R:R:L75	39.9514	2.77	No	No	1	8	9
39	R:R:L124	R:R:M279	31.7507	4.24	No	No	1	8	8
40	R:R:M279	R:R:Y219	30.3885	9.58	No	Yes	0	8	9
41	R:R:V222	R:R:Y219	20.1376	2.52	No	Yes	0	8	9
42	R:R:V222	R:R:Y132	18.0065	5.05	No	Yes	0	8	8
43	R:R:R131	R:R:Y141	28.0415	8.23	Yes	Yes	1	9	7
44	R:R:F264	R:R:Y141	24.1705	4.13	Yes	Yes	1	4	7
45	R:R:F208	R:R:F290	22.1068	27.86	No	Yes	0	8	7
46	R:R:F208	R:R:L287	13.5824	3.65	No	Yes	0	8	6
47	R:R:T274	R:R:Y326	11.1141	7.49	Yes	Yes	2	8	9
48	R:R:F321	R:R:T281	11.3839	3.89	No	No	0	6	6
49	R:R:N318	R:R:T281	13.5824	5.85	Yes	No	0	9	6
50	R:R:F332	R:R:F336	27.8527	11.79	Yes	Yes	2	9	7
51	R:R:F336	R:R:Q337	13.5824	2.34	Yes	No	0	7	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 2R4S

PDB Summary
PDB	2R4S
Class	A
SubFamily	Amine
Type	Adrenergic
SubType	Beta2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.4
Date	2007-11-06
D.O.I.	doi.org/10.1038/nature06325

Net Summary
I_min	2.85
Number of Linked Nodes	200
Number of Links	213
Number of Hubs	27
Number of Links mediated by Hubs	102
Number of Communities	4
Number of Nodes involved in Communities	38
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	52
Number Of Links MetaPath	51
Number of Shortest Paths	14863
Length Of Smallest Path	3
Average Path Length	12.3656
Length of Longest Path	30
Minimum Path Strength	1.22
Average Path Strength	6.69562
Maximum Path Strength	19.04
Minimum Path Correlation	0.7
Average Path Correlation	0.942375
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	61.0876
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.3208
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>2R4S_Chain_R G I V M S L I V L A I V F G N V L V I T A I A F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E G R F H V F C L K E H K A L K T L G I I M G T F T L C W L P F F I L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E L L C L R R S S L K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	2R4R	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	doi.org/10.1016/j.str.2008.05.001
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	doi.org/10.1038/nature08650
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 913103	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.16	2010-08-11	doi.org/10.1021/ja105108q
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	FAUC50	-	-	3.5	2011-01-12	doi.org/10.1038/nature09665
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	doi.org/10.1038/nature09648
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	doi.org/10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	doi.org/10.1038/nature10361
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.99	2012-10-24	doi.org/10.1371/journal.pone.0046039
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	doi.org/10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzyl Isoproterenol	-	-	3.1	2013-09-25	doi.org/10.1038/nature12572
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	Epinephrine	-	-	3.2	2013-09-25	doi.org/10.1038/nature12572
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 76210628	-	-	3.3	2014-07-23	doi.org/10.1073/pnas.1410415111
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	2.48	2016-01-13	doi.org/10.1107/S2059798315021683
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.8	2016-01-13	doi.org/10.1107/S2059798315021683
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.2	2016-07-13	doi.org/10.1038/nature18636
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.2	2016-08-17	doi.org/10.1038/nprot.2017.057
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	PubChem 129318963	-	2.7	2017-08-16	doi.org/10.1038/nature23652
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	doi.org/10.1038/s41589-018-0145-x
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	doi.org/10.1126/science.aaw8981
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	2.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	Carvedilol	-	-	2.5	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	Propranolol	-	-	2.9	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	doi.org/10.1107/S2052252519013137
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	GTPL11074	-	3.1	2020-03-25	doi.org/10.1038/s41589-020-0549-2
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8GE2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ1	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ1	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Norepinephrine	-	-	3.49	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHV	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.95	2024-11-13	doi.org/10.1073/pnas.2414544121
	9U9V	A	Amine	Adrenergic	β₂	Homo sapiens	METH	-	Gs/β1/γ2	2.85	2025-09-03	To be published
	9U9V (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	METH	-		2.85	2025-09-03	To be published
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	Carazolol	-	-	3.5	2024-11-13	doi.org/10.1073/pnas.2414544121
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9M55	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	DPMF	-	chim(NtGi1-Gs)/β1/γ2	3.39	2025-12-17	10.1093/pnasnexus/pgaf376
	9M55 (No Gprot)	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	DPMF	-		3.39	2025-12-17	10.1093/pnasnexus/pgaf376
	9M57	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	Octopamine	-	chim(NtGi1-Gs)/β1/γ2	3.65	2025-12-17	10.1093/pnasnexus/pgaf376
	9M57 (No Gprot)	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	Octopamine	-		3.65	2025-12-17	10.1093/pnasnexus/pgaf376
	9L8L	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	Atazanavir	Gs/β1/γ2 ; Arrestin2	3.22	2025-12-31	To be published
	9L8L (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	Atazanavir		3.22	2025-12-31	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 2R4S.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.