psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D113	13.14	Yes	No	1	0	7
2	L:L:?1	R:R:V117	8.66	Yes	No	1	0	6
3	L:L:?1	R:R:F193	11.79	Yes	Yes	0	0	4
4	L:L:?1	R:R:S203	8.72	Yes	No	0	0	5
5	L:L:?1	R:R:F289	10.61	Yes	Yes	1	0	6
6	L:L:?1	R:R:F290	7.08	Yes	Yes	1	0	7
7	L:L:?1	R:R:N293	2.66	Yes	Yes	0	0	5
8	L:L:?1	R:R:N312	14.63	Yes	No	1	0	5
9	L:L:?1	R:R:Y316	3.41	Yes	Yes	1	0	6
10	R:R:E30	R:R:R28	6.98	No	No	0	3	5
11	R:R:E30	R:R:V34	7.13	No	No	0	3	5
12	R:R:G35	R:R:V34	3.68	No	No	0	5	5
13	R:R:I38	R:R:V39	3.07	No	No	0	5	5
14	R:R:I43	R:R:V39	3.07	No	No	0	6	5
15	R:R:M40	R:R:W313	6.98	No	Yes	0	6	5
16	R:R:I43	R:R:I47	2.94	No	No	0	6	8
17	R:R:V44	R:R:V87	3.21	No	No	0	6	7
18	R:R:L80	R:R:V48	2.98	Yes	No	5	7	6
19	R:R:L84	R:R:V48	2.98	No	No	5	5	6
20	R:R:D79	R:R:N51	4.04	Yes	No	0	9	9
21	R:R:L80	R:R:N51	6.87	Yes	No	0	7	9
22	R:R:N51	R:R:P323	3.26	No	No	0	9	9
23	R:R:L340	R:R:L53	2.77	No	No	0	6	6
24	R:R:P323	R:R:V54	3.53	No	No	0	9	9
25	R:R:C327	R:R:V54	3.42	No	No	0	7	9
26	R:R:A76	R:R:I55	3.25	No	No	0	9	7
27	R:R:I55	R:R:L80	2.85	No	Yes	0	7	7
28	R:R:A57	R:R:F336	2.77	No	No	0	8	7
29	R:R:I58	R:R:T73	3.04	No	No	0	7	6
30	R:R:F332	R:R:I58	3.77	Yes	No	0	9	7
31	R:R:F61	R:R:K60	16.13	Yes	No	0	6	5
32	R:R:F61	R:R:L64	2.44	Yes	No	0	6	8
33	R:R:A335	R:R:F61	2.77	No	Yes	6	7	6
34	R:R:E338	R:R:F61	16.32	No	Yes	6	4	6
35	R:R:I334	R:R:R63	3.76	No	No	0	4	6
36	R:R:F332	R:R:L64	2.44	Yes	No	0	9	8
37	R:R:Q65	R:R:Y70	6.76	No	No	0	8	4
38	R:R:N69	R:R:T66	5.85	No	No	0	9	7
39	R:R:D130	R:R:T68	7.23	No	No	0	8	8
40	R:R:I72	R:R:N69	2.83	No	No	0	8	9
41	R:R:K147	R:R:Y70	4.78	No	No	0	1	4
42	R:R:F71	R:R:V126	5.24	Yes	No	0	8	7
43	R:R:F71	R:R:I127	3.77	Yes	Yes	0	8	9
44	R:R:A150	R:R:F71	2.77	No	Yes	0	7	8
45	R:R:F71	R:R:I154	5.02	Yes	No	0	8	8
46	R:R:I154	R:R:S74	4.64	No	No	0	8	9
47	R:R:S74	R:R:W158	6.18	No	Yes	0	9	9
48	R:R:D79	R:R:L75	4.07	Yes	Yes	3	9	9
49	R:R:L75	R:R:T123	5.9	Yes	No	0	9	8
50	R:R:L124	R:R:L75	2.77	No	Yes	0	8	9
51	R:R:L75	R:R:N322	4.12	Yes	No	3	9	9
52	R:R:A78	R:R:W158	2.59	No	Yes	0	8	9
53	R:R:D79	R:R:M82	2.77	Yes	Yes	3	9	7
54	R:R:D79	R:R:S120	7.36	Yes	No	0	9	9
55	R:R:D79	R:R:S319	10.31	Yes	No	3	9	9
56	R:R:D79	R:R:N322	5.39	Yes	No	3	9	9
57	R:R:L80	R:R:L84	2.77	Yes	No	5	7	5
58	R:R:C116	R:R:V81	3.42	No	No	0	7	7
59	R:R:G83	R:R:M82	3.49	No	Yes	0	7	7
60	R:R:M82	R:R:V86	3.04	Yes	Yes	0	7	7
61	R:R:C116	R:R:M82	8.1	No	Yes	0	7	7
62	R:R:M82	R:R:S319	4.6	Yes	No	3	7	9
63	R:R:V86	R:R:W109	4.9	Yes	No	0	7	5
64	R:R:I112	R:R:V86	3.07	No	Yes	0	4	7
65	R:R:V86	R:R:Y316	2.52	Yes	Yes	0	7	6
66	R:R:P88	R:R:V87	5.3	No	No	0	8	7
67	R:R:V87	R:R:W313	3.68	No	Yes	0	7	5
68	R:R:F89	R:R:W99	4.01	No	Yes	2	5	7
69	R:R:F101	R:R:F89	6.43	No	No	2	5	5
70	R:R:G90	R:R:W109	5.63	No	No	0	7	5
71	R:R:A91	R:R:W313	2.59	No	Yes	0	6	5
72	R:R:H93	R:R:W99	8.46	No	Yes	2	4	7
73	R:R:C191	R:R:H93	2.95	Yes	No	2	9	4
74	R:R:I309	R:R:I94	4.42	No	No	0	3	5
75	R:R:F101	R:R:W99	7.02	No	Yes	2	5	7
76	R:R:C106	R:R:W99	2.61	No	Yes	2	9	7
77	R:R:C191	R:R:W99	6.53	Yes	Yes	2	9	7
78	R:R:F101	R:R:W105	5.01	No	No	0	5	5
79	R:R:G102	R:R:W105	2.81	No	No	0	7	5
80	R:R:E188	R:R:G102	4.91	No	No	0	3	7
81	R:R:E188	R:R:N103	9.2	No	No	0	3	2
82	R:R:F104	R:R:W105	20.04	No	No	0	1	5
83	R:R:C106	R:R:C191	7.28	No	Yes	2	9	9
84	R:R:E107	R:R:I169	2.73	No	Yes	4	5	5
85	R:R:E107	R:R:Y174	12.35	No	Yes	4	5	5
86	R:R:C191	R:R:W109	2.61	Yes	No	0	9	5
87	R:R:I169	R:R:T110	3.04	Yes	No	0	5	4
88	R:R:F193	R:R:T110	5.19	Yes	No	0	4	4
89	R:R:F166	R:R:S111	10.57	Yes	No	0	4	6
90	R:R:I169	R:R:S111	3.1	Yes	No	0	5	6
91	R:R:F166	R:R:I112	2.51	Yes	No	0	4	4
92	R:R:D113	R:R:Y316	11.49	No	Yes	1	7	6
93	R:R:S165	R:R:V114	3.23	Yes	No	0	7	5
94	R:R:L115	R:R:S161	4.5	No	No	0	5	8
95	R:R:L115	R:R:S165	7.51	No	Yes	7	5	7
96	R:R:F166	R:R:L115	3.65	Yes	No	7	4	5
97	R:R:I121	R:R:V117	3.07	Yes	No	1	7	6
98	R:R:V117	R:R:W286	4.9	No	Yes	1	6	8
99	R:R:S161	R:R:T118	6.4	No	No	0	8	6
100	R:R:S207	R:R:T118	4.8	No	No	0	5	6
101	R:R:A119	R:R:W158	7.78	No	Yes	0	7	9
102	R:R:A119	R:R:S161	3.42	No	No	0	7	8
103	R:R:I121	R:R:S207	3.1	Yes	No	1	7	5
104	R:R:F282	R:R:I121	2.51	Yes	Yes	1	9	7
105	R:R:I121	R:R:W286	8.22	Yes	Yes	1	7	8
106	R:R:F290	R:R:I121	2.51	Yes	Yes	1	7	7
107	R:R:E122	R:R:V157	5.7	No	No	0	5	7
108	R:R:L124	R:R:Y326	3.52	No	No	0	8	9
109	R:R:C125	R:R:P211	3.77	Yes	No	0	7	8
110	R:R:C125	R:R:I214	4.91	Yes	No	0	7	6
111	R:R:I127	R:R:R131	2.51	Yes	No	0	9	9
112	R:R:I127	R:R:Y326	4.84	Yes	No	0	9	9
113	R:R:A128	R:R:Y219	2.67	No	Yes	0	8	9
114	R:R:F133	R:R:V129	2.62	No	No	0	5	6
115	R:R:F133	R:R:Y132	5.16	No	Yes	0	5	8
116	R:R:T136	R:R:Y132	13.73	No	Yes	0	7	8
117	R:R:V218	R:R:Y132	7.57	No	Yes	0	6	8
118	R:R:V222	R:R:Y132	2.52	No	Yes	0	8	8
119	R:R:F133	R:R:L144	2.44	No	No	0	5	4
120	R:R:A134	R:R:Y141	8.01	No	No	0	8	7
121	R:R:E225	R:R:I135	4.1	Yes	No	0	5	9
122	R:R:S137	R:R:T136	4.8	No	No	0	6	7
123	R:R:E225	R:R:T136	7.06	Yes	No	0	5	7
124	R:R:L144	R:R:S143	4.5	No	No	0	4	4
125	R:R:K149	R:R:V152	3.04	No	No	0	5	4
126	R:R:G162	R:R:S165	3.71	No	Yes	0	4	7
127	R:R:F166	R:R:S165	6.61	Yes	Yes	7	4	7
128	R:R:L167	R:R:P168	3.28	No	No	8	5	5
129	R:R:L167	R:R:W173	7.97	No	No	8	5	4
130	R:R:P168	R:R:W173	5.4	No	No	8	5	4
131	R:R:P168	R:R:Y199	8.34	No	No	0	5	6
132	R:R:I169	R:R:Y174	4.84	Yes	Yes	4	5	5
133	R:R:M171	R:R:W173	16.29	No	No	0	4	4
134	R:R:H172	R:R:R175	32.72	No	No	0	4	2
135	R:R:R175	R:R:Y174	8.23	No	Yes	4	2	5
136	R:R:Y174	R:R:Y185	10.92	Yes	No	4	5	1
137	R:R:F193	R:R:Y174	5.16	Yes	Yes	0	4	5
138	R:R:R175	R:R:Y185	28.81	No	No	4	2	1
139	R:R:A176	R:R:N196	3.13	No	No	0	1	4
140	R:R:I182	R:R:Q179	4.12	No	No	0	1	3
141	R:R:A181	R:R:F194	5.55	No	Yes	0	4	1
142	R:R:C184	R:R:N183	4.72	No	No	0	1	3
143	R:R:E187	R:R:N183	7.89	No	No	0	7	3
144	R:R:C184	R:R:C190	7.28	No	No	9	1	3
145	R:R:F194	R:R:Y185	4.13	Yes	No	0	1	1
146	R:R:E187	R:R:T189	4.23	No	No	0	7	4
147	R:R:D192	R:R:F194	3.58	No	Yes	0	3	1
148	R:R:F193	R:R:T195	7.78	Yes	No	0	4	3
149	R:R:F194	R:R:K305	2.48	Yes	No	0	1	2
150	R:R:I201	R:R:Q197	5.49	No	No	0	5	2
151	R:R:S203	R:R:Y199	2.54	No	No	0	5	6
152	R:R:I201	R:R:I205	2.94	No	No	0	5	4
153	R:R:F290	R:R:S204	5.28	Yes	No	0	7	5
154	R:R:N293	R:R:S204	2.98	Yes	No	0	5	5
155	R:R:I294	R:R:S204	4.64	No	No	0	6	5
156	R:R:F290	R:R:S207	5.28	Yes	No	1	7	5
157	R:R:F208	R:R:Y209	7.22	Yes	No	0	8	5
158	R:R:F208	R:R:L212	2.44	Yes	No	0	8	7
159	R:R:F208	R:R:F282	5.36	Yes	Yes	1	8	9
160	R:R:F208	R:R:W286	3.01	Yes	Yes	1	8	8
161	R:R:F208	R:R:L287	3.65	Yes	No	0	8	6
162	R:R:F208	R:R:F290	17.15	Yes	Yes	1	8	7
163	R:R:I294	R:R:Y209	3.63	No	No	0	6	5
164	R:R:P211	R:R:V210	3.53	No	No	0	8	5
165	R:R:F282	R:R:M215	3.73	Yes	No	0	9	8
166	R:R:F217	R:R:R221	8.55	No	No	10	4	5
167	R:R:I278	R:R:Y219	4.84	No	Yes	0	8	9
168	R:R:M279	R:R:Y219	4.79	No	Yes	0	8	9
169	R:R:E225	R:R:R221	6.98	Yes	No	0	5	5
170	R:R:E225	R:R:V222	8.56	Yes	No	0	5	8
171	R:R:F223	R:R:K227	4.96	Yes	No	0	6	6
172	R:R:A271	R:R:F223	2.77	No	Yes	0	8	6
173	R:R:F223	R:R:L272	3.65	Yes	No	0	6	7
174	R:R:F223	R:R:L275	3.65	Yes	No	0	6	8
175	R:R:E268	R:R:K227	13.5	No	No	0	7	6
176	R:R:D234	R:R:L230	4.07	No	No	0	4	5
177	R:R:D234	R:R:I233	4.2	No	No	0	4	6
178	R:R:I233	R:R:S236	3.1	No	No	0	6	4
179	R:R:E237	R:R:S236	8.62	No	No	0	3	4
180	R:R:E237	R:R:H241	3.69	No	No	0	3	3
181	R:R:F240	R:R:R239	14.97	No	No	0	4	4
182	R:R:H269	R:R:K270	3.93	No	No	0	5	7
183	R:R:I325	R:R:T281	4.56	No	No	0	8	6
184	R:R:F282	R:R:W286	6.01	Yes	Yes	1	9	8
185	R:R:L287	R:R:T283	4.42	No	No	0	6	7
186	R:R:C285	R:R:N318	9.45	No	No	0	9	9
187	R:R:F290	R:R:W286	3.01	Yes	Yes	1	7	8
188	R:R:G315	R:R:W286	8.44	No	Yes	0	7	8
189	R:R:N318	R:R:W286	4.52	No	Yes	0	9	8
190	R:R:L287	R:R:P288	3.28	No	No	0	6	9
191	R:R:L311	R:R:P288	3.28	Yes	No	0	5	9
192	R:R:F289	R:R:F290	3.22	Yes	Yes	1	6	7
193	R:R:F289	R:R:Y308	8.25	Yes	No	0	6	5
194	R:R:F289	R:R:L311	2.44	Yes	Yes	0	6	5
195	R:R:F289	R:R:N312	13.29	Yes	No	1	6	5
196	R:R:I303	R:R:V292	3.07	Yes	No	0	3	5
197	R:R:L311	R:R:V292	4.47	Yes	No	0	5	5
198	R:R:H296	R:R:N293	7.65	No	Yes	0	3	5
199	R:R:N293	R:R:Y308	3.49	Yes	No	0	5	5
200	R:R:L302	R:R:V295	2.98	No	No	11	1	4
201	R:R:I303	R:R:V295	4.61	Yes	No	11	3	4
202	R:R:H296	R:R:V297	6.92	No	No	0	3	5
203	R:R:H296	R:R:I303	2.65	No	Yes	0	3	3
204	R:R:L302	R:R:Q299	7.99	No	No	0	1	2
205	R:R:D300	R:R:N301	10.77	No	No	0	1	2
206	R:R:I303	R:R:L302	2.85	Yes	No	11	3	1
207	R:R:L311	R:R:V307	2.98	Yes	No	0	5	4
208	R:R:I314	R:R:L310	2.85	No	No	0	7	5
209	R:R:N312	R:R:Y316	10.47	No	Yes	1	5	6
210	R:R:W313	R:R:Y316	2.89	Yes	Yes	0	5	6
211	R:R:N318	R:R:N322	6.81	No	No	0	9	9
212	R:R:I325	R:R:Y326	4.84	No	No	0	8	9
213	R:R:C327	R:R:F332	16.76	No	Yes	0	7	9
214	R:R:P330	R:R:S329	3.56	No	No	0	5	8
215	R:R:D331	R:R:S329	4.42	No	No	0	7	8
216	R:R:F332	R:R:S329	6.61	Yes	No	0	9	8
217	R:R:F332	R:R:F336	5.36	Yes	No	0	9	7
218	R:R:E338	R:R:I334	4.1	No	No	0	4	4
219	R:R:A335	R:R:E338	3.02	No	No	6	7	4
220	R:R:F332	R:R:N69	2.42	Yes	No	0	9	9
221	R:R:I309	R:R:W313	2.35	No	Yes	0	3	5
222	R:R:L145	R:R:Y141	2.34	No	No	0	7	7
223	R:R:L275	R:R:Y219	2.34	No	Yes	0	8	9
224	R:R:G320	R:R:S319	1.86	No	No	0	7	9
225	R:R:P138	R:R:S137	1.78	No	No	0	8	6
226	R:R:G35	R:R:I38	1.76	No	No	0	5	5
227	R:R:G83	R:R:I47	1.76	No	No	0	7	8
228	R:R:G320	R:R:I47	1.76	No	No	0	7	8
229	R:R:G280	R:R:M279	1.75	No	No	0	5	8
230	R:R:C77	R:R:V81	1.71	No	No	0	6	7
231	R:R:C125	R:R:V129	1.71	Yes	No	0	7	6
232	R:R:G276	R:R:L275	1.71	No	No	0	6	8
233	R:R:A85	R:R:V86	1.7	No	Yes	0	4	7
234	R:R:A200	R:R:V297	1.7	No	No	0	5	5
235	R:R:A92	R:R:T96	1.68	No	No	0	4	4
236	R:R:C125	R:R:M215	1.62	Yes	No	0	7	8
237	R:R:A128	R:R:M215	1.61	No	No	0	8	8
238	R:R:T56	R:R:V52	1.59	No	No	0	5	3
239	R:R:T96	R:R:T98	1.57	No	No	0	4	5
240	R:R:T189	R:R:T98	1.57	No	No	0	4	5
241	R:R:T118	R:R:T164	1.57	No	No	0	6	5
242	R:R:C184	R:R:D192	1.56	No	No	9	1	3
243	R:R:C190	R:R:D192	1.56	No	No	9	3	3
244	R:R:A198	R:R:N196	1.56	No	No	0	4	4
245	R:R:I153	R:R:V126	1.54	No	No	0	6	7
246	R:R:I205	R:R:V210	1.54	No	No	0	4	5
247	R:R:I214	R:R:V213	1.54	No	No	0	6	4
248	R:R:I291	R:R:V292	1.54	No	No	0	6	5
249	R:R:I298	R:R:V295	1.54	No	No	0	4	4
250	R:R:K147	R:R:V67	1.52	No	No	0	1	6
251	R:R:M156	R:R:V152	1.52	No	No	0	4	4
252	R:R:M279	R:R:V216	1.52	No	No	0	8	5
253	R:R:I278	R:R:T274	1.52	No	No	0	8	8
254	R:R:F49	R:R:G50	1.51	No	No	0	4	8
255	R:R:K149	R:R:T146	1.5	No	No	0	5	8
256	R:R:N148	R:R:V152	1.48	No	No	0	4	4
257	R:R:L53	R:R:T56	1.47	No	No	0	6	5
258	R:R:I277	R:R:I325	1.47	No	No	0	7	8
259	R:R:A181	R:R:H178	1.46	No	No	0	4	2
260	R:R:I153	R:R:K149	1.45	No	No	0	6	5
261	R:R:I277	R:R:K273	1.45	No	No	0	7	7
262	R:R:M36	R:R:M40	1.44	No	No	0	5	6
263	R:R:I38	R:R:L42	1.43	No	No	0	5	5
264	R:R:E122	R:R:V160	1.43	No	No	0	5	4
265	R:R:E122	R:R:V206	1.43	No	No	0	5	4
266	R:R:L95	R:R:M36	1.41	No	No	0	6	5
267	R:R:D130	R:R:I127	1.4	No	Yes	0	8	9
268	R:R:L339	R:R:L53	1.38	No	No	0	6	6
269	R:R:L144	R:R:L145	1.38	No	No	0	4	7
270	R:R:K232	R:R:Q229	1.36	No	No	0	4	7
271	R:R:E268	R:R:L230	1.33	No	No	0	7	5
272	R:R:F108	R:R:S111	1.32	No	No	0	5	6
273	R:R:F217	R:R:S220	1.32	No	No	10	4	3
274	R:R:R221	R:R:S220	1.32	No	No	10	5	3
275	R:R:R28	R:R:V31	1.31	No	No	0	5	2
276	R:R:F49	R:R:V52	1.31	No	No	0	4	3
277	R:R:D300	R:R:Q299	1.31	No	No	0	1	2
278	R:R:R304	R:R:V307	1.31	No	No	0	4	4
279	R:R:F321	R:R:T281	1.3	No	No	0	6	6
280	R:R:I277	R:R:R328	1.25	No	No	0	7	7
281	R:R:K232	R:R:R228	1.24	No	No	0	4	4
282	R:R:V31	R:R:W32	1.23	No	No	0	2	3
283	R:R:V157	R:R:W158	1.23	No	Yes	0	7	9
284	R:R:F61	R:R:L339	1.22	Yes	No	0	6	6
285	R:R:I154	R:R:Y70	1.21	No	No	0	8	4
286	R:R:N196	R:R:Y199	1.16	No	No	0	4	6
287	R:R:E306	R:R:R304	1.16	No	No	0	2	4
288	R:R:F240	R:R:H241	1.13	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.96667	9	1	0
2	R:R:F61	7.776	5	6	6
3	R:R:F71	4.2	4	0	8
4	R:R:L75	4.215	4	3	9
5	R:R:D79	5.65667	6	3	9
6	R:R:L80	3.8675	4	5	7
7	R:R:M82	4.4	5	3	7
8	R:R:V86	3.046	5	0	7
9	R:R:W99	5.726	5	2	7
10	R:R:I121	3.882	5	1	7
11	R:R:C125	3.0025	4	0	7
12	R:R:I127	3.13	4	0	9
13	R:R:Y132	7.245	4	0	8
14	R:R:W158	4.445	4	0	9
15	R:R:S165	5.265	4	7	7
16	R:R:F166	5.835	4	7	4
17	R:R:I169	3.4275	4	4	5
18	R:R:Y174	8.3	5	4	5
19	R:R:C191	4.8425	4	2	9
20	R:R:F193	7.48	4	0	4
21	R:R:F194	3.935	4	0	1
22	R:R:F208	6.47167	6	1	8
23	R:R:Y219	3.66	4	0	9
24	R:R:F223	3.7575	4	0	6
25	R:R:E225	6.675	4	0	5
26	R:R:F282	4.4025	4	1	9
27	R:R:W286	5.44429	7	1	8
28	R:R:F289	7.562	5	1	6
29	R:R:F290	6.21857	7	1	7
30	R:R:N293	4.195	4	0	5
31	R:R:I303	3.295	4	11	3
32	R:R:L311	3.2925	4	0	5
33	R:R:W313	3.698	5	0	5
34	R:R:Y316	6.156	5	1	6
35	R:R:F332	6.22667	6	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y316	40.8226	3.41	Yes	Yes	1	0	6
2	R:R:V86	R:R:Y316	35.315	2.52	Yes	Yes	0	7	6
3	R:R:M82	R:R:V86	23.753	3.04	Yes	Yes	0	7	7
4	R:R:I43	R:R:I47	12.0269	2.94	No	No	0	6	8
5	R:R:I43	R:R:V39	10.8512	3.07	No	No	0	6	5
6	R:R:W313	R:R:Y316	14.8703	2.89	Yes	Yes	0	5	6
7	R:R:D79	R:R:M82	23.2791	2.77	Yes	Yes	3	9	7
8	R:R:D79	R:R:N51	26.5417	4.04	Yes	No	0	9	9
9	R:R:N51	R:R:P323	22.3677	3.26	No	No	0	9	9
10	R:R:P323	R:R:V54	21.6508	3.53	No	No	0	9	9
11	R:R:C327	R:R:V54	20.9278	3.42	No	No	0	7	9
12	R:R:C327	R:R:F332	20.1987	16.76	No	Yes	0	7	9
13	R:R:F332	R:R:L64	11.7778	2.44	Yes	No	0	9	8
14	R:R:F61	R:R:L64	10.9758	2.44	Yes	No	0	6	8
15	L:L:?1	R:R:F290	47.1414	7.08	Yes	Yes	1	0	7
16	R:R:S207	R:R:T118	10.8694	4.8	No	No	0	5	6
17	R:R:A119	R:R:S161	11.5043	3.42	No	No	0	7	8
18	R:R:A119	R:R:W158	10.8269	7.78	No	Yes	0	7	9
19	L:L:?1	R:R:V117	29.5461	8.66	Yes	No	1	0	6
20	R:R:V117	R:R:W286	16.5502	4.9	No	Yes	1	6	8
21	R:R:N318	R:R:W286	28.5892	4.52	No	Yes	0	9	8
22	R:R:N318	R:R:N322	27.7812	6.81	No	No	0	9	9
23	R:R:L75	R:R:N322	12.0147	4.12	Yes	No	3	9	9
24	R:R:L124	R:R:L75	21.7298	2.77	No	Yes	0	8	9
25	R:R:L124	R:R:Y326	20.8062	3.52	No	No	0	8	9
26	R:R:I127	R:R:Y326	14.2992	4.84	Yes	No	0	9	9
27	R:R:F290	R:R:W286	25.4299	3.01	Yes	Yes	1	7	8
28	R:R:D79	R:R:L75	11.5651	4.07	Yes	Yes	3	9	9
29	R:R:F71	R:R:I127	10.6537	3.77	Yes	Yes	0	8	9
30	R:R:V86	R:R:W109	18.9137	4.9	Yes	No	0	7	5
31	R:R:C191	R:R:W109	16.1249	2.61	Yes	No	0	9	5
32	R:R:C191	R:R:W99	11.7838	6.53	Yes	Yes	2	9	7
33	L:L:?1	R:R:F193	35.1054	11.79	Yes	Yes	0	0	4
34	R:R:F193	R:R:Y174	27.9968	5.16	Yes	Yes	0	4	5
35	R:R:I121	R:R:V117	13.2876	3.07	Yes	No	1	7	6
36	R:R:F290	R:R:I121	18.0023	2.51	Yes	Yes	1	7	7
37	R:R:F282	R:R:I121	34.7257	2.51	Yes	Yes	1	9	7
38	R:R:F282	R:R:W286	46.0508	6.01	Yes	Yes	1	9	8
39	R:R:F208	R:R:F290	19.6336	17.15	Yes	Yes	1	8	7
40	R:R:F208	R:R:F282	20.949	5.36	Yes	Yes	1	8	9
41	R:R:F282	R:R:M215	100	3.73	Yes	No	0	9	8
42	R:R:C125	R:R:M215	59.7059	1.62	Yes	No	0	7	8
43	R:R:C125	R:R:P211	10.0523	3.77	Yes	No	0	7	8
44	R:R:A128	R:R:M215	42.7335	1.61	No	No	0	8	8
45	R:R:A128	R:R:Y219	40.8378	2.67	No	Yes	0	8	9
46	R:R:C125	R:R:V129	44.8083	1.71	Yes	No	0	7	6
47	R:R:F133	R:R:V129	42.9188	2.62	No	No	0	5	6
48	R:R:F133	R:R:Y132	31.4539	5.16	No	Yes	0	5	8
49	R:R:T136	R:R:Y132	15.6905	13.73	No	Yes	0	7	8
50	R:R:V222	R:R:Y132	11.9084	2.52	No	Yes	0	8	8
51	R:R:F133	R:R:L144	10.0523	2.44	No	No	0	5	4
52	L:L:?1	R:R:S203	14.5149	8.72	Yes	No	0	0	5
53	R:R:S203	R:R:Y199	12.9261	2.54	No	No	0	5	6
54	R:R:Y174	R:R:Y185	20.9521	10.92	Yes	No	4	5	1
55	R:R:F194	R:R:Y185	19.6063	4.13	Yes	No	0	1	1
56	R:R:D192	R:R:F194	13.6946	3.58	No	Yes	0	3	1
57	R:R:C184	R:R:D192	10.672	1.56	No	No	9	1	3
58	L:L:?1	R:R:N293	18.057	2.66	Yes	Yes	0	0	5
59	R:R:E225	R:R:R221	11.9539	6.98	Yes	No	0	5	5
60	R:R:L275	R:R:Y219	29.3365	2.34	No	Yes	0	8	9
61	R:R:F223	R:R:L275	25.4542	3.65	Yes	No	0	6	8
62	R:R:F223	R:R:K227	19.579	4.96	Yes	No	0	6	6
63	R:R:E268	R:R:K227	17.6074	13.5	No	No	0	7	6
64	R:R:E268	R:R:L230	15.8242	1.33	No	No	0	7	5
65	R:R:D234	R:R:L230	14.0318	4.07	No	No	0	4	5
66	R:R:D234	R:R:I233	12.0451	4.2	No	No	0	4	6
67	R:R:I233	R:R:S236	10.0523	3.1	No	No	0	6	4
68	R:R:F289	R:R:L311	14.0622	2.44	Yes	Yes	0	6	5
69	R:R:H296	R:R:N293	22.5804	7.65	No	Yes	0	3	5
70	R:R:H296	R:R:I303	15.9183	2.65	No	Yes	0	3	3
71	R:R:I303	R:R:L302	12.598	2.85	Yes	No	11	3	1
72	R:R:D79	R:R:N322	15.5356	5.39	Yes	No	3	9	9
73	R:R:F289	R:R:F290	11.8993	3.22	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D113	13.14	1	Yes	No	0	7	0	1
L:L:?1	R:R:V117	8.66	1	Yes	No	0	6	0	1
L:L:?1	R:R:F193	11.79	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S203	8.72	1	Yes	No	0	5	0	1
L:L:?1	R:R:F289	10.61	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F290	7.08	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N293	2.66	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N312	14.63	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y316	3.41	1	Yes	Yes	0	6	0	1
R:R:V86	R:R:Y316	2.52	0	Yes	Yes	7	6	2	1
R:R:F193	R:R:T110	5.19	0	Yes	No	4	4	1	2
R:R:D113	R:R:Y316	11.49	1	No	Yes	7	6	1	1
R:R:I121	R:R:V117	3.07	1	Yes	No	7	6	2	1
R:R:V117	R:R:W286	4.9	1	No	Yes	6	8	1	2
R:R:I121	R:R:S207	3.1	1	Yes	No	7	5	2	2
R:R:I121	R:R:W286	8.22	1	Yes	Yes	7	8	2	2
R:R:F290	R:R:I121	2.51	1	Yes	Yes	7	7	1	2
R:R:F193	R:R:Y174	5.16	0	Yes	Yes	4	5	1	2
R:R:F193	R:R:T195	7.78	0	Yes	No	4	3	1	2
R:R:S203	R:R:Y199	2.54	0	No	No	5	6	1	2
R:R:F290	R:R:S204	5.28	1	Yes	No	7	5	1	2
R:R:N293	R:R:S204	2.98	0	Yes	No	5	5	1	2
R:R:F290	R:R:S207	5.28	1	Yes	No	7	5	1	2
R:R:F208	R:R:W286	3.01	1	Yes	Yes	8	8	2	2
R:R:F208	R:R:F290	17.15	1	Yes	Yes	8	7	2	1
R:R:F290	R:R:W286	3.01	1	Yes	Yes	7	8	1	2
R:R:F289	R:R:F290	3.22	1	Yes	Yes	6	7	1	1
R:R:F289	R:R:Y308	8.25	1	Yes	No	6	5	1	2
R:R:F289	R:R:L311	2.44	1	Yes	Yes	6	5	1	2
R:R:F289	R:R:N312	13.29	1	Yes	No	6	5	1	1
R:R:H296	R:R:N293	7.65	0	No	Yes	3	5	2	1
R:R:N293	R:R:Y308	3.49	0	Yes	No	5	5	1	2
R:R:N312	R:R:Y316	10.47	1	No	Yes	5	6	1	1
R:R:W313	R:R:Y316	2.89	0	Yes	Yes	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8UNX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	256
Number of Links	288
Number of Hubs	35
Number of Links mediated by Hubs	141
Number of Communities	11
Number of Nodes involved in Communities	49
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	60957
Length Of Smallest Path	3
Average Path Length	13.3091
Length of Longest Path	33
Minimum Path Strength	1.235
Average Path Strength	4.62006
Maximum Path Strength	30.765
Minimum Path Correlation	0.7
Average Path Correlation	0.935862
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	54.9038
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.517
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amide binding • amyloid-beta binding • binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • monoatomic cation transmembrane transporter activity • channel regulator activity • ion channel regulator activity • monoatomic ion channel activity • potassium ion transmembrane transporter activity • potassium channel activity • potassium channel regulator activity • monoatomic cation channel activity • passive transmembrane transporter activity • inorganic molecular entity transmembrane transporter activity • channel activity • molecular function regulator activity • inorganic cation transmembrane transporter activity • monoatomic ion transmembrane transporter activity • transporter activity • transporter regulator activity • metal ion transmembrane transporter activity • transmembrane transporter activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold
Gene Ontology	Biological Process	• multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • regulation of biological process • bone mineralization • animal organ development • biological regulation • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • positive regulation of phosphorylation • regulation of catalytic activity • regulation of transferase activity • positive regulation of phosphate metabolic process • cell surface receptor protein tyrosine kinase signaling pathway • cellular component biogenesis • cellular component assembly • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • activation of transmembrane receptor protein tyrosine kinase activity • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of molecular function • positive regulation of kinase activity • regulation of kinase activity • activation of protein kinase activity • macromolecule modification • regulation of phosphorus metabolic process • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • cellular component organization • positive regulation of molecular function • positive regulation of protein modification process • protein-containing complex assembly • cellular component organization or biogenesis • protein metabolic process • positive regulation of protein kinase activity • enzyme-linked receptor protein signaling pathway • positive regulation of transferase activity • cell surface receptor signaling pathway • protein-containing complex organization • positive regulation of catalytic activity • regulation of protein kinase activity • regulation of phosphorylation • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • autophagosome maturation • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • protein-containing complex • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • cell periphery • apical part of cell • plasma membrane • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	G1I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	G1I
Name	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier
Formula	C11 H15 N O3
Molecular Weight	209.242
SMILES
PubChem	12353638
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	2
Total Bonds	31
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>8UNX_nogp_Chain_R R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L T K T W T F G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S F L P I Q M H W Y R A T H Q E A I N C Y A E E T C C D F F T N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E G R F H E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q D N L I R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9CHV	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.95	2024-11-13	10.1073/pnas.2414544121
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Noradrenaline	-	-	3.49	2024-11-13	10.1073/pnas.2414544121
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.5	2024-11-13	10.1073/pnas.2414544121
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	8W1V (Multimeric)	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-		3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	10.1038/s41467-023-37808-y
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	10.1038/s41589-023-01389-0
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Formoterol	-	-	3.2	2023-09-06	10.1038/s41589-023-01389-0
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	10.1093/nsr/nwaa284
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	10.1093/nsr/nwaa284
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	10.1038/s41421-020-0176-9
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	GTPL11074	-	3.1	2020-03-25	10.1038/s41589-020-0549-2
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	10.1038/s41594-019-0330-y
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	S-Propranolol	-	-	2.9	2019-11-13	10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carvedilol	-	-	2.5	2019-11-13	10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.4	2019-11-13	10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.4	2019-11-13	10.1107/S2052252519013137
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.8	2019-11-13	10.1107/S2052252519013137
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	10.1126/science.aaw8981
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs (fused)	3.7	2019-06-05	10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	10.1016/j.cell.2019.04.021
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	10.1038/s41589-018-0145-x
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	PubChem 129318963	-	2.7	2017-08-16	10.1038/nature23652
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-08-17	10.1038/nprot.2017.057
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-07-13	10.1038/nature18636
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.8	2016-01-13	10.1107/S2059798315021683
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.48	2016-01-13	10.1107/S2059798315021683
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	35V	-	-	3.3	2014-07-23	10.1073/pnas.1410415111
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	L-Epinephrine	-	-	3.2	2013-09-25	10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.1	2013-09-25	10.1038/nature12572
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	10.1038/nature12572
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.99	2012-10-24	10.1371/journal.pone.0046039
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	10.1038/nature10361
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	10.1038/nature09648
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.5	2011-01-12	10.1038/nature09665
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	3.16	2010-08-11	10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	10.1021/ja105108q
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	10.1021/ja105108q
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	10.1038/nature08650
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	10.1016/j.str.2008.05.001
	2R4S	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	10.1038/nature06325
	2R4R	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	10.1038/nature06325
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	10.1126/science.1150577

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