Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M40 4.016506
2R:R:I43 7.7825406
3R:R:I58 4.325407
4R:R:F61 4.9275416
5R:R:L64 4.89518
6R:R:N69 5.072519
7R:R:Y70 11.6525434
8R:R:F71 4.135428
9R:R:V86 4.94407
10R:R:W99 4.77833657
11R:R:W109 4.355405
12R:R:L115 3.605405
13R:R:I121 6.705447
14R:R:I127 2.805409
15R:R:R131 3.6325409
16R:R:Y132 7.014598
17R:R:I135 4.9125409
18R:R:Y199 6.636506
19R:R:F208 6.582548
20R:R:L212 5.2175447
21R:R:Y219 4.5825489
22R:R:E268 4.0475407
23R:R:H269 6.105405
24R:R:M279 3.808588
25R:R:I294 3.004506
26R:R:Y308 7.6525405
27R:R:W313 6.44405
28R:R:N318 5.595409
29R:R:Y326 5.272509
30R:R:F332 5.685419
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M40 R:R:W313 25.50113.49YesYes065
2R:R:I94 R:R:W313 10.21392.35NoYes055
3R:R:W313 R:R:Y316 10.252216.4YesNo056
4R:R:M40 R:R:V44 12.41973.04YesNo066
5R:R:D79 R:R:S319 15.968210.31NoNo099
6R:R:N318 R:R:S319 87.17752.98YesNo099
7R:R:F282 R:R:N318 44.83556.04NoYes099
8R:R:F208 R:R:F282 41.31584.29YesNo489
9R:R:F208 R:R:F290 10013.93YesNo087
10R:R:F290 R:R:N293 99.05056.04NoNo075
11R:R:N293 R:R:Y308 66.3474.65NoYes055
12R:R:F289 R:R:Y308 50.71459.28NoYes065
13R:R:F289 R:R:N312 48.997814.5NoNo065
14R:R:I309 R:R:N312 47.49214.25NoNo035
15R:R:I309 R:R:W313 45.7373.52NoYes035
16R:R:I72 R:R:Y326 17.416313.3NoYes089
17R:R:I127 R:R:I72 44.54782.94YesNo098
18R:R:I127 R:R:M279 61.20652.92YesYes098
19R:R:M215 R:R:M279 69.64612.89NoYes088
20R:R:L212 R:R:M215 71.3342.83YesNo078
21R:R:F208 R:R:L212 67.69924.87YesYes487
22R:R:I278 R:R:Y326 31.49523.63NoYes089
23R:R:I278 R:R:L124 35.23544.28NoNo088
24R:R:L124 R:R:M279 46.70572.83NoYes088
25R:R:I58 R:R:N69 28.26325.66YesYes079
26R:R:I72 R:R:N69 39.82932.83NoYes089
27R:R:F61 R:R:L64 10.01252.44YesYes168
28R:R:L64 R:R:N69 10.69345.49YesYes189
29R:R:F332 R:R:Y326 20.78264.13YesYes099
30R:R:I58 R:R:Y70 12.55392.42YesYes074
31R:R:A128 R:R:M279 61.3123.22NoYes888
32R:R:A128 R:R:V218 60.73651.7NoNo086
33R:R:V129 R:R:V218 59.16376.41NoNo066
34R:R:D130 R:R:V129 57.57172.92NoNo086
35R:R:D130 R:R:R131 55.96053.57NoYes089
36R:R:R131 R:R:Y141 51.2422.06YesNo097
37R:R:F71 R:R:I127 18.5482.51YesYes089
38R:R:F71 R:R:I154 10.4922.51YesNo288
39R:R:N318 R:R:N322 56.89085.45YesNo099
40R:R:L75 R:R:N322 56.66066.87NoNo099
41R:R:M82 R:R:S319 74.8253.07NoNo079
42R:R:M82 R:R:V86 69.87634.56NoYes077
43R:R:F89 R:R:W109 15.96822NoYes055
44R:R:V86 R:R:W109 64.72627.36YesYes075
45R:R:F89 R:R:W99 13.74324.01NoYes057
46R:R:I169 R:R:T110 13.50343.04NoNo054
47R:R:T110 R:R:W109 48.71972.43NoYes045
48R:R:A200 R:R:T195 28.28231.68NoNo053
49R:R:A200 R:R:V297 30.19081.7NoNo055
50R:R:I294 R:R:V297 35.57113.07YesNo065
51R:R:I294 R:R:N293 49.68832.83YesNo065
52R:R:D113 R:R:T110 35.10122.89NoNo074
53R:R:D113 R:R:V114 33.07765.84NoNo075
54R:R:S165 R:R:V114 31.0061.62NoNo075
55R:R:L115 R:R:S165 28.91533YesNo057
56R:R:L115 R:R:S161 22.52813YesNo058
57R:R:N318 R:R:W286 13.74327.91YesNo098
58R:R:E122 R:R:S161 13.74327.19NoNo058
59R:R:V222 R:R:Y132 16.94645.05NoYes088
60R:R:I135 R:R:V222 18.91244.61YesNo098
61R:R:E268 R:R:I135 33.88325.47YesYes079
62R:R:A134 R:R:E268 46.28371.51NoYes087
63R:R:A134 R:R:Y141 48.019.34NoNo087
64R:R:H269 R:R:I135 12.32387.95YesYes059
65R:R:T195 R:R:Y199 20.65792.5NoYes036
66R:R:P168 R:R:Y199 12.764918.08NoYes056
67R:R:V292 R:R:Y308 14.78852.52NoYes055
68R:R:V292 R:R:V307 12.75531.6NoNo054
69R:R:F332 R:R:N69 10.61678.46YesYes199
70R:R:L124 R:R:L75 56.31532.77NoNo089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9CHV
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.95
Date 2024-11-13
D.O.I. doi.org/10.1073/pnas.2414544121
Net Summary
Imin 2.43
Number of Linked Nodes 236
Number of Links 248
Number of Hubs 30
Number of Links mediated by Hubs 113
Number of Communities 9
Number of Nodes involved in Communities 37
Number of Links involved in Communities 43
Path Summary
Number Of Nodes in MetaPath 71
Number Of Links MetaPath 70
Number of Shortest Paths 25926
Length Of Smallest Path 3
Average Path Length 14.0478
Length of Longest Path 32
Minimum Path Strength 1.325
Average Path Strength 4.98226
Maximum Path Strength 17.87
Minimum Path Correlation 0.7
Average Path Correlation 0.925023
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 46.8264
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.7948
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• amyloid-beta binding   • binding   • peptide binding   • protein binding   • enzyme binding   • adenylate cyclase binding   • G protein-coupled amine receptor activity   • molecular transducer activity   • beta2-adrenergic receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • beta-adrenergic receptor activity   • adrenergic receptor activity   • protein-containing complex binding   • potassium channel regulator activity   • channel regulator activity   • ion channel regulator activity   • molecular function regulator activity   • transporter regulator activity   • identical protein binding   • protein homodimerization activity   • protein dimerization activity   • cation binding   • ion binding   • catecholamine binding   • norepinephrine binding   • small molecule binding   • calcium ion binding   • metal ion binding   • protein domain specific binding   • enzyme regulator activity   • calcium-dependent protein serine/threonine phosphatase regulator activity   • phosphatase regulator activity   • protein phosphatase regulator activity   • phosphoric ester hydrolase activity   • phosphoprotein phosphatase activity   • protein serine/threonine phosphatase activity   • catalytic activity, acting on a protein   • hydrolase activity, acting on ester bonds   • phosphatase activity   • hydrolase activity   • calcium-dependent protein serine/threonine phosphatase activity   • catalytic activity   • calmodulin binding   • phosphatase binding   • multicellular organismal process   • response to nutrient levels   • multicellular organismal-level homeostasis   • response to stimulus   • homeostatic process   • response to dietary excess   • diet induced thermogenesis   • temperature homeostasis   • energy homeostasis   • adaptive thermogenesis   • response to stress   • response to abiotic stimulus   • response to cold   • response to temperature stimulus
Gene OntologyBiological Process• multicellular organismal process   • response to nutrient levels   • multicellular organismal-level homeostasis   • response to stimulus   • homeostatic process   • response to dietary excess   • diet induced thermogenesis   • temperature homeostasis   • energy homeostasis   • adaptive thermogenesis   • response to stress   • response to abiotic stimulus   • response to cold   • response to temperature stimulus   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • biological regulation   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-inhibiting adrenergic receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • adrenergic receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • regulation of developmental process   • positive regulation of biological process   • regulation of biomineral tissue development   • regulation of bone mineralization   • positive regulation of ossification   • positive regulation of developmental process   • multicellular organism development   • positive regulation of biomineral tissue development   • ossification   • anatomical structure development   • biomineral tissue development   • regulation of multicellular organismal process   • developmental process   • regulation of multicellular organismal development   • bone mineralization   • animal organ development   • tissue development   • positive regulation of bone mineralization   • positive regulation of multicellular organismal process   • regulation of ossification   • regulation of multicellular organism growth   • regulation of growth   • regulation of developmental growth   • negative regulation of multicellular organism growth   • developmental growth   • negative regulation of developmental process   • growth   • negative regulation of biological process   • multicellular organism growth   • negative regulation of developmental growth   • negative regulation of growth   • negative regulation of multicellular organismal process   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • fat cell differentiation   • cellular developmental process   • brown fat cell differentiation   • cell differentiation   • negative regulation of cardiac muscle cell apoptotic process   • muscle cell apoptotic process   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of cardiac muscle cell apoptotic process   • regulation of muscle cell apoptotic process   • regulation of programmed cell death   • cell death   • cardiac muscle cell apoptotic process   • negative regulation of apoptotic process   • regulation of striated muscle cell apoptotic process   • striated muscle cell apoptotic process   • negative regulation of muscle cell apoptotic process   • negative regulation of cellular process   • negative regulation of striated muscle cell apoptotic process   • apoptotic process   • programmed cell death   • system process   • regulation of system process   • muscle contraction   • muscle system process   • regulation of muscle system process   • negative regulation of muscle contraction   • smooth muscle contraction   • regulation of smooth muscle contraction   • regulation of muscle contraction   • negative regulation of smooth muscle contraction   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • positive regulation of metabolic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • positive regulation of cellular process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • regulation of transcription by RNA polymerase II   • primary metabolic process   • regulation of macromolecule metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • regulation of gene expression   • biosynthetic process   • positive regulation of RNA biosynthetic process   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of DNA-templated transcription   • regulation of metabolic process   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • localization   • import into cell   • transport   • receptor-mediated endocytosis   • endocytosis   • establishment of localization   • vesicle-mediated transport   • cellular localization   • endosome to lysosome transport   • intracellular transport   • lysosomal transport   • establishment of localization in cell   • vacuolar transport   • heart process   • regulation of actin filament-based process   • regulation of heart contraction   • cardiac muscle contraction   • striated muscle contraction   • circulatory system process   • actin filament-based process   • positive regulation of actin filament-based movement   • blood circulation   • cardiac muscle cell contraction   • regulation of cardiac muscle contraction   • positive regulation of cardiac muscle cell contraction   • actin filament-based movement   • regulation of blood circulation   • regulation of striated muscle contraction   • regulation of actin filament-based movement   • regulation of cardiac muscle cell contraction   • actin-mediated cell contraction   • heart contraction   • positive regulation of organelle organization   • catabolic process   • regulation of cellular component organization   • positive regulation of cellular component organization   • regulation of autophagosome maturation   • macroautophagy   • autophagy   • protein-containing complex disassembly   • regulation of autophagy   • regulation of protein-containing complex disassembly   • cellular component organization   • autophagosome maturation   • cellular component organization or biogenesis   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • positive regulation of protein-containing complex disassembly   • cellular component disassembly   • positive regulation of autophagy   • protein-containing complex organization   • regulation of catabolic process   • positive regulation of autophagosome maturation   • regulation of organelle organization   • positive regulation of catabolic process   • organelle organization   • regulation of macroautophagy   • positive regulation of cardiac muscle cell apoptotic process   • positive regulation of programmed cell death   • positive regulation of striated muscle cell apoptotic process   • positive regulation of apoptotic process   • positive regulation of muscle cell apoptotic process   • lipophagy   • positive regulation of lipophagy   • regulation of lipophagy   • response to psychosocial stress   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • positive regulation of cold-induced thermogenesis   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • positive regulation of signaling   • cell surface receptor signaling pathway   • ligand-gated ion channel signaling pathway   • ionotropic glutamate receptor signaling pathway   • glutamate receptor signaling pathway   • AMPA selective glutamate receptor signaling pathway   • regulation of tube diameter   • regulation of systemic arterial blood pressure mediated by a chemical signal   • regulation of blood pressure   • regulation of tube size   • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure   • negative regulation of blood pressure   • regulation of systemic arterial blood pressure by norepinephrine-epinephrine   • regulation of systemic arterial blood pressure   • negative regulation of systemic arterial blood pressure   • vascular process in circulatory system   • regulation of biological quality   • blood vessel diameter maintenance   • vasodilation   • regulation of anatomical structure size   • negative regulation of signaling   • negative regulation of response to stimulus   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • cellular response to nitrogen compound   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to amyloid-beta   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • response to chemical   • response to amyloid-beta   • regulation of localization   • regulation of transport   • regulation of monoatomic ion transport   • regulation of sodium ion transport   • metal ion transport   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • sodium ion transport   • heat generation   • regulation of postsynaptic membrane potential   • modulation of chemical synaptic transmission   • positive regulation of excitatory postsynaptic potential   • chemical synaptic transmission, postsynaptic   • synaptic signaling   • modulation of excitatory postsynaptic potential   • mini excitatory postsynaptic potential   • trans-synaptic signaling   • nervous system process   • cell-cell signaling   • chemical synaptic transmission   • regulation of nervous system process   • regulation of mini excitatory postsynaptic potential   • positive regulation of mini excitatory postsynaptic potential   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • excitatory postsynaptic potential   • regulation of membrane potential   • calcineurin-NFAT signaling cascade   • calcium-mediated signaling   • calcineurin-mediated signaling   • heart development   • circulatory system development   • system development   • peripheral nervous system axon ensheathment   • peripheral nervous system development   • cell development   • nervous system development   • glial cell development   • myelination   • neurogenesis   • Schwann cell development   • gliogenesis   • axon ensheathment   • ensheathment of neurons   • glial cell differentiation   • myelination in peripheral nervous system   • Schwann cell differentiation   • regulation of calcineurin-mediated signaling   • positive regulation of calcineurin-NFAT signaling cascade   • regulation of calcium-mediated signaling   • positive regulation of calcium-mediated signaling   • regulation of calcineurin-NFAT signaling cascade   • positive regulation of calcineurin-mediated signaling   • regulation of calcium ion transport   • monoatomic ion transmembrane transport   • negative regulation of monoatomic ion transport   • negative regulation of transport   • regulation of monoatomic ion transmembrane transport   • calcium ion transport   • negative regulation of transmembrane transport   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • negative regulation of monoatomic ion transmembrane transport   • negative regulation of cation transmembrane transport   • negative regulation of calcium ion import across plasma membrane   • calcium ion import into cytosol   • regulation of calcium ion import   • calcium ion transmembrane import into cytosol   • import across plasma membrane   • inorganic cation import across plasma membrane   • negative regulation of calcium ion import   • negative regulation of calcium ion transport   • transmembrane transport   • regulation of transmembrane transport   • calcium ion import across plasma membrane   • regulation of calcium ion import across plasma membrane   • inorganic ion import across plasma membrane   • regulation of monoatomic cation transmembrane transport   • calcium ion import   • negative regulation of calcium ion transmembrane transport   • calcium ion transmembrane transport   • establishment of protein localization   • nucleocytoplasmic transport   • nuclear transport   • protein localization to nucleus   • import into nucleus   • establishment of protein localization to organelle   • protein transport   • macromolecule localization   • protein localization to organelle   • protein import into nucleus   • intracellular protein localization   • intracellular protein transport   • postsynaptic modulation of chemical synaptic transmission   • branching morphogenesis of an epithelial tube   • angiogenesis   • tube morphogenesis   • epithelial tube morphogenesis   • blood vessel development   • epithelium development   • blood vessel morphogenesis   • tube development   • morphogenesis of an epithelium   • vasculature development   • branching involved in blood vessel morphogenesis   • anatomical structure morphogenesis   • tissue morphogenesis   • morphogenesis of a branching structure   • anatomical structure formation involved in morphogenesis   • morphogenesis of a branching epithelium   • mesenchyme development   • mesenchymal cell differentiation   • epithelial to mesenchymal transition   • positive regulation of cation transmembrane transport   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of calcium ion import across plasma membrane   • positive regulation of monoatomic ion transport   • positive regulation of calcium ion transmembrane transport   • positive regulation of transmembrane transport   • positive regulation of monoatomic ion transmembrane transport   • positive regulation of transport   • respiratory tube development   • lung epithelium development   • epithelial cell differentiation   • lung epithelial cell differentiation   • lung cell differentiation   • lung development   • respiratory system development   • regulation of synaptic vesicle cycle   • synaptic vesicle cycle   • regulation of vesicle-mediated transport   • vesicle-mediated transport in synapse   • receptor internalization   • postsynaptic neurotransmitter receptor internalization   • regulation of receptor internalization   • regulation of postsynaptic neurotransmitter receptor internalization   • regulation of endocytosis   • regulation of receptor-mediated endocytosis   • neurotransmitter receptor internalization   • regulation of postsynaptic membrane neurotransmitter receptor levels   • postsynaptic endocytosis   • cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • neuronal dense core vesicle   • bounding membrane of organelle   • vesicle membrane   • clathrin-coated vesicle   • endocytic vesicle membrane   • coated vesicle   • endocytic vesicle   • clathrin-coated vesicle membrane   • clathrin-coated endocytic vesicle membrane   • clathrin-coated endocytic vesicle   • cytoplasmic vesicle membrane   • coated vesicle membrane   • organelle membrane   • protein-containing complex   • receptor complex   • intercellular bridge   • Golgi apparatus   • endosome membrane   • endosome   • intracellular membraneless organelle   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • microtubule cytoskeleton   • cell periphery   • apical part of cell   • plasma membrane   • plasma membrane region   • apical plasma membrane   • mitotic spindle   • spindle   • lytic vacuole   • vacuole   • lysosome   • early endosome   • nucleus   • phosphatase complex   • catalytic complex   • protein serine/threonine phosphatase complex   • cytosol   • parallel fiber to Purkinje cell synapse   • synapse   • cell junction   • excitatory synapse   • sarcolemma   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • glutamatergic synapse   • neuron to neuron synapse   • hippocampal mossy fiber to CA3 synapse   • calcineurin complex   • intracellular protein-containing complex   • Schaffer collateral - CA1 synapse   • postsynapse   • isomerase activity   • catalytic activity, acting on a protein   • peptidyl-prolyl cis-trans isomerase activity   • catalytic activity   • cis-trans isomerase activity   • transforming growth factor beta receptor binding   • protein binding   • binding   • signaling receptor binding   • type I transforming growth factor beta receptor binding   • cytokine receptor binding   • FK506 binding   • macrolide binding   • activin receptor binding   • receptor serine/threonine kinase binding   • transmembrane receptor protein serine/threonine kinase binding   • channel regulator activity   • ion channel regulator activity   • calcium channel regulator activity   • molecular function regulator activity   • transporter regulator activity   • transmembrane transporter binding   • SMAD binding   • I-SMAD binding   • molecular function inhibitor activity   • signaling receptor inhibitor activity   • signaling receptor regulator activity   • protein refolding   • primary metabolic process   • gene expression   • macromolecule biosynthetic process   • protein maturation   • protein folding   • biosynthetic process   • metabolic process   • cellular process   • protein metabolic process   • macromolecule metabolic process   • cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • positive regulation of canonical NF-kappaB signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • regulation of biological process   • regulation of signaling   • biological regulation   • positive regulation of intracellular signal transduction   • canonical NF-kappaB signal transduction   • regulation of response to stimulus   • regulation of cell communication   • regulation of canonical NF-kappaB signal transduction   • positive regulation of signaling   • activin receptor signaling pathway   • cell surface receptor protein serine/threonine kinase signaling pathway   • negative regulation of signaling   • regulation of transmembrane receptor protein serine/threonine kinase signaling pathway   • negative regulation of biological process   • negative regulation of cell communication   • negative regulation of activin receptor signaling pathway   • negative regulation of cellular process   • enzyme-linked receptor protein signaling pathway   • cell surface receptor signaling pathway   • negative regulation of response to stimulus   • negative regulation of signal transduction   • transforming growth factor beta receptor superfamily signaling pathway   • regulation of activin receptor signaling pathway   • negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway   • cellular component organization   • cellular component organization or biogenesis   • supramolecular fiber organization   • amyloid fibril formation   • amyloid precursor protein catabolic process   • regulation of protein metabolic process   • regulation of amyloid precursor protein catabolic process   • regulation of macromolecule metabolic process   • regulation of primary metabolic process   • amyloid precursor protein metabolic process   • regulation of metabolic process   • immune response   • immune system process   • regulation of immune response   • regulation of immune system process   • developmental process   • heart development   • multicellular organismal process   • cardiac chamber morphogenesis   • heart trabecula formation   • animal organ development   • heart morphogenesis   • circulatory system development   • anatomical structure morphogenesis   • multicellular organism development   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • cardiac chamber development   • animal organ morphogenesis   • heart trabecula morphogenesis   • trabecula formation   • trabecula morphogenesis   • system development   • T cell activation   • cell activation   • lymphocyte activation   • leukocyte activation   • negative regulation of transforming growth factor beta receptor signaling pathway   • cellular response to growth factor stimulus   • cellular response to transforming growth factor beta stimulus   • regulation of transforming growth factor beta receptor signaling pathway   • cellular response to endogenous stimulus   • regulation of cellular response to transforming growth factor beta stimulus   • response to endogenous stimulus   • regulation of cellular response to growth factor stimulus   • response to transforming growth factor beta   • transforming growth factor beta receptor signaling pathway   • response to growth factor   • regulation of localization   • localization   • regulation of protein localization   • macromolecule localization   • intracellular protein localization   • regulation of calcium ion transport   • system process   • regulation of heart contraction   • regulation of system process   • sarcoplasmic reticulum calcium ion transport   • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum   • cardiac muscle contraction   • calcium ion transport   • circulatory system process   • monoatomic cation transport   • release of sequestered calcium ion into cytosol by endoplasmic reticulum   • regulation of release of sequestered calcium ion into cytosol   • regulation of monoatomic ion transport   • regulation of cardiac muscle contraction   • muscle contraction   • establishment of localization   • transmembrane transport   • release of sequestered calcium ion into cytosol   • regulation of transmembrane transport   • regulation of blood circulation   • regulation of striated muscle contraction   • calcium-mediated signaling   • regulation of muscle contraction   • heart process   • transport   • monoatomic ion transmembrane transport   • regulation of monoatomic ion transmembrane transport   • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion   • metal ion transport   • striated muscle contraction   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • monoatomic ion transport   • regulation of multicellular organismal process   • regulation of metal ion transport   • blood circulation   • calcium ion transmembrane import into cytosol   • regulation of cardiac muscle contraction by calcium ion signaling   • regulation of transport   • muscle system process   • regulation of muscle system process   • regulation of monoatomic cation transmembrane transport   • heart contraction   • calcium ion transmembrane transport   • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum   • 'de novo' protein folding   • multicellular organismal movement   • regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion   • regulation of skeletal muscle contraction by calcium ion signaling   • skeletal muscle contraction   • musculoskeletal movement   • regulation of skeletal muscle contraction   • nervous system process   • neuromuscular process   • ventricular cardiac muscle tissue morphogenesis   • striated muscle tissue development   • muscle structure development   • ventricular cardiac muscle tissue development   • muscle tissue development   • muscle organ development   • cardiac muscle tissue development   • tissue development   • muscle tissue morphogenesis   • tissue morphogenesis   • cardiac ventricle morphogenesis   • cardiac muscle tissue morphogenesis   • cardiac ventricle development   • muscle organ morphogenesis   • organelle subcompartment   • sarcoplasm   • endoplasmic reticulum subcompartment   • terminal cisterna   • endoplasmic reticulum   • sarcoplasmic reticulum   • Z disc   • sarcomere   • I band   • contractile muscle fiber   • supramolecular fiber   • myofibril   • supramolecular polymer   • supramolecular complex   • nuclear outer membrane-endoplasmic reticulum membrane network   • sarcoplasmic reticulum membrane   • endoplasmic reticulum membrane   • cytoplasmic side of membrane   • side of membrane   • membrane protein complex   • ryanodine receptor complex   • transporter complex   • endoplasmic reticulum protein-containing complex   • plasma membrane protein complex   • voltage-gated calcium channel complex   • cation channel complex   • transmembrane transporter complex   • calcium channel complex   • monoatomic ion channel complex   • phosphoric ester hydrolase activity   • phosphoprotein phosphatase activity   • protein serine/threonine phosphatase activity   • hydrolase activity, acting on ester bonds   • phosphatase activity   • hydrolase activity   • protein-containing complex binding   • calmodulin binding   • protein dimerization activity   • cation binding   • ion binding   • metal ion binding   • small molecule binding   • ATPase binding   • enzyme binding   • calmodulin-dependent protein phosphatase activity   • calcium-dependent protein serine/threonine phosphatase activity   • calcineurin-NFAT signaling cascade   • calcineurin-mediated signaling   • renal system process   • renal filtration   • response to metal ion   • response to chemical   • response to calcium ion   • regulation of developmental process   • regulation of kidney development   • positive regulation of glomerulus development   • positive regulation of kidney development   • renal system development   • positive regulation of developmental process   • glomerulus development   • regulation of glomerulus development   • positive regulation of multicellular organismal process   • nephron development   • kidney development   • regulation of biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • protein dephosphorylation   • dephosphorylation   • macromolecule modification   • phosphate-containing compound metabolic process   • protein modification process   • phosphorus metabolic process   • regulated exocytosis   • synaptic vesicle cycle   • positive regulation of neurotransmitter secretion   • synaptic vesicle exocytosis   • positive regulation of calcium ion-dependent exocytosis of neurotransmitter   • vesicle-mediated transport   • vesicle-mediated transport in synapse   • positive regulation of regulated secretory pathway   • establishment of localization in cell   • calcium ion-regulated exocytosis of neurotransmitter   • trans-synaptic signaling   • positive regulation of neurotransmitter transport   • neurotransmitter secretion   • regulation of synaptic vesicle exocytosis   • positive regulation of synaptic transmission   • neurotransmitter transport   • regulation of secretion   • signal release from synapse   • exocytosis   • regulation of trans-synaptic signaling   • cellular localization   • regulation of calcium ion-dependent exocytosis of neurotransmitter   • modulation of chemical synaptic transmission   • regulation of calcium ion-dependent exocytosis   • positive regulation of secretion by cell   • positive regulation of exocytosis   • regulation of regulated secretory pathway   • synaptic signaling   • secretion by cell   • regulation of secretion by cell   • positive regulation of secretion   • signal release   • calcium-ion regulated exocytosis   • positive regulation of calcium ion-dependent exocytosis   • positive regulation of synaptic vesicle exocytosis   • secretion   • regulation of neurotransmitter transport   • export from cell   • cell-cell signaling   • regulation of vesicle-mediated transport   • chemical synaptic transmission   • positive regulation of transport   • regulation of neurotransmitter secretion   • anterograde trans-synaptic signaling   • regulation of exocytosis   • import into cell   • negative regulation of monoatomic ion transport   • negative regulation of transport   • negative regulation of transmembrane transport   • negative regulation of monoatomic ion transmembrane transport   • negative regulation of cation transmembrane transport   • negative regulation of calcium ion import across plasma membrane   • calcium ion import into cytosol   • regulation of calcium ion import   • import across plasma membrane   • inorganic cation import across plasma membrane   • negative regulation of calcium ion import   • negative regulation of calcium ion transport   • calcium ion import across plasma membrane   • regulation of calcium ion import across plasma membrane   • inorganic ion import across plasma membrane   • calcium ion import   • negative regulation of calcium ion transmembrane transport   • establishment of protein localization   • nucleocytoplasmic transport   • nuclear transport   • intracellular transport   • protein localization to nucleus   • import into nucleus   • establishment of protein localization to organelle   • protein transport   • protein localization to organelle   • protein import into nucleus   • intracellular protein transport   • response to stress   • multicellular organismal response to stress   • postsynaptic modulation of chemical synaptic transmission   • mitotic cell cycle process   • cell cycle phase transition   • cell cycle   • G1/S transition of mitotic cell cycle   • cell cycle G1/S phase transition   • mitotic cell cycle   • mitotic cell cycle phase transition   • cell cycle process   • muscle hypertrophy   • regulation of muscle adaptation   • positive regulation of cardiac muscle hypertrophy   • striated muscle hypertrophy   • regulation of cardiac muscle hypertrophy   • regulation of muscle hypertrophy   • muscle adaptation   • positive regulation of muscle hypertrophy   • cardiac muscle hypertrophy   • regulation of body fluid levels   • digestive system process   • saliva secretion   • regulation of saliva secretion   • positive regulation of digestive system process   • regulation of biological quality   • secretion by tissue   • regulation of digestive system process   • body fluid secretion   • digestion   • positive regulation of saliva secretion   • striated muscle adaptation   • positive regulation of cardiac muscle hypertrophy in response to stress   • regulation of cardiac muscle hypertrophy in response to stress   • cardiac muscle adaptation   • regulation of response to stress   • positive regulation of muscle adaptation   • cardiac muscle hypertrophy in response to stress   • positive regulation of cardiac muscle adaptation   • regulation of cardiac muscle adaptation   • muscle hypertrophy in response to stress   • positive regulation of DNA-templated transcription   • RNA metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • regulation of DNA-templated transcription   • renal sodium ion transport   • renal absorption   • renal sodium ion absorption   • sodium ion transport   • epithelium development   • epidermal cell differentiation   • cellular developmental process   • epidermis development   • epithelial cell differentiation   • skin development   • cell differentiation   • keratinocyte differentiation   • myotube cell development   • skeletal muscle fiber development   • skeletal muscle tissue development   • cell development   • muscle cell differentiation   • myotube differentiation   • skeletal muscle organ development   • striated muscle cell development   • muscle cell development   • striated muscle cell differentiation   • cellular response to nitrogen compound   • response to angiotensin   • positive regulation of angiotensin-activated signaling pathway   • response to peptide hormone   • angiotensin-activated signaling pathway   • cellular response to angiotensin   • response to hormone   • regulation of G protein-coupled receptor signaling pathway   • cellular response to hormone stimulus   • response to oxygen-containing compound   • cellular response to peptide hormone stimulus   • response to nitrogen compound   • positive regulation of G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • regulation of angiotensin-activated signaling pathway   • cellular response to chemical stimulus   • G protein-coupled receptor signaling pathway   • transition between fast and slow fiber   • regulation of skeletal muscle adaptation   • skeletal muscle adaptation   • homeostatic process   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • response to hexose   • cellular response to carbohydrate stimulus   • cellular homeostasis   • response to monosaccharide   • response to carbohydrate   • chemical homeostasis   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • intracellular chemical homeostasis   • cellular response to monosaccharide stimulus   • positive regulation of tissue remodeling   • positive regulation of connective tissue replacement   • regulation of tissue remodeling   • tissue remodeling   • connective tissue replacement   • regulation of connective tissue replacement   • regulation of calcineurin-mediated signaling   • positive regulation of calcineurin-NFAT signaling cascade   • regulation of calcium-mediated signaling   • positive regulation of calcium-mediated signaling   • regulation of calcineurin-NFAT signaling cascade   • positive regulation of calcineurin-mediated signaling   • cell population proliferation   • regulation of cell proliferation involved in kidney morphogenesis   • kidney morphogenesis   • regulation of cell population proliferation   • cell projection organization   • regulation of cell differentiation   • regulation of neurogenesis   • neuron projection development   • regulation of cell development   • cell projection morphogenesis   • neuron differentiation   • neuron projection morphogenesis   • regulation of dendrite morphogenesis   • negative regulation of cellular component organization   • regulation of cell projection organization   • nervous system development   • generation of neurons   • regulation of dendrite development   • negative regulation of multicellular organismal process   • regulation of neuron projection development   • regulation of cellular component organization   • plasma membrane bounded cell projection morphogenesis   • cell morphogenesis   • regulation of nervous system development   • negative regulation of neurogenesis   • neurogenesis   • dendrite development   • negative regulation of nervous system development   • negative regulation of cell differentiation   • negative regulation of cell projection organization   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • plasma membrane bounded cell projection organization   • negative regulation of dendrite morphogenesis   • negative regulation of developmental process   • dendrite morphogenesis   • cell morphogenesis involved in neuron differentiation   • negative regulation of cell development   • neuron development   • regulation of plasma membrane bounded cell projection organization   • catabolic process   • proteasomal protein catabolic process   • protein catabolic process   • proteasome-mediated ubiquitin-dependent protein catabolic process   • macromolecule catabolic process   • modification-dependent macromolecule catabolic process   • modification-dependent protein catabolic process   • ubiquitin-dependent protein catabolic process   • negative regulation of protein transport   • nitrogen compound transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • negative regulation of protein localization   • regulation of peptide transport   • regulation of establishment of protein localization   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • insulin secretion   • cell adhesion   • positive regulation of cell adhesion   • regulation of cell adhesion   • regulation of postsynaptic membrane potential   • chemical synaptic transmission, postsynaptic   • excitatory postsynaptic potential   • regulation of membrane potential   • positive regulation of cell population proliferation   • regulation of leukocyte activation   • regulation of cell activation   • positive regulation of cell activation   • lymphocyte proliferation   • positive regulation of leukocyte activation   • positive regulation of immune system process   • regulation of leukocyte proliferation   • positive regulation of T cell activation   • positive regulation of lymphocyte proliferation   • positive regulation of T cell proliferation   • positive regulation of activated T cell proliferation   • mononuclear cell proliferation   • regulation of leukocyte cell-cell adhesion   • positive regulation of leukocyte proliferation   • regulation of activated T cell proliferation   • positive regulation of leukocyte cell-cell adhesion   • leukocyte proliferation   • leukocyte cell-cell adhesion   • activated T cell proliferation   • positive regulation of cell-cell adhesion   • positive regulation of lymphocyte activation   • cell-cell adhesion   • positive regulation of mononuclear cell proliferation   • regulation of cell-cell adhesion   • T cell proliferation   • regulation of lymphocyte proliferation   • regulation of T cell activation   • regulation of T cell proliferation   • regulation of mononuclear cell proliferation   • regulation of lymphocyte activation   • positive regulation of cation transmembrane transport   • positive regulation of calcium ion transport   • positive regulation of calcium ion import   • positive regulation of calcium ion import across plasma membrane   • positive regulation of monoatomic ion transport   • positive regulation of calcium ion transmembrane transport   • positive regulation of transmembrane transport   • positive regulation of monoatomic ion transmembrane transport   • regulation of osteoblast differentiation   • osteoblast differentiation   • positive regulation of osteoblast differentiation   • ossification   • positive regulation of cell differentiation   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of angiotensin-activated signaling pathway   • negative regulation of metabolic process   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of macromolecule metabolic process   • positive regulation of cellular component organization   • positive regulation of endocytosis   • endocytosis   • regulation of endocytosis   • myeloid leukocyte differentiation   • regulation of leukocyte differentiation   • positive regulation of osteoclast differentiation   • regulation of osteoclast differentiation   • positive regulation of hemopoiesis   • osteoclast differentiation   • hemopoiesis   • regulation of myeloid cell differentiation   • positive regulation of cell development   • regulation of myeloid leukocyte differentiation   • positive regulation of myeloid leukocyte differentiation   • myeloid cell differentiation   • positive regulation of myeloid cell differentiation   • regulation of hemopoiesis   • positive regulation of leukocyte differentiation   • leukocyte differentiation   • neuron spine   • neuron projection   • dendritic spine   • somatodendritic compartment   • dendrite   • dendritic tree   • mitochondrion   • cell-cell junction   • anchoring junction   • filtration diaphragm   • slit diaphragm   • cytoplasmic side of plasma membrane
SCOP2Domain Identifier• EF-hand   • G protein-coupled receptor-like   • Rotamase-like   • Metallo-dependent phosphatases
SCOP2Family Identifier• EF-hand   • G protein-coupled receptor-like   • Rotamase-like   • Metallo-dependent phosphatases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>9CHV_Chain_R
WVVGMGIVM SLIVLAIVF GNVLVITAI AKFERLQTV TNYFITSLA 
CADLVMGLA VVPFGAAHI LMKMWTFGN FWCEFWTSI DVLCVTASI 
ETLCVIAVD RYFAITSPF KYQSLLTKN KARVIILMV WIVSGLTSF 
LPIQMHWYC DFFTNQAYA IASSIVSFY VPLVIMVFV YSRVFQEAK 
RQLKFCLKE HKALKTLGI IMGTFTLCW LPFFIVNIV HVIQDNLIR 
KEVYILLNW IGYVNSGFN PLIYCRSPD FRIAFQE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2RH1AAmineAdrenergicβ2Homo sapiensCarazolol--2.42007-10-30doi.org/10.1126/science.1150577
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
3D4SAAmineAdrenergicβ2Homo sapiensTimolol--2.82008-06-17doi.org/10.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-16doi.org/10.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI118-551--2.842010-08-11doi.org/10.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-11doi.org/10.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiensAlprenolol--3.162010-08-11doi.org/10.1021/ja105108q
3PDSAAmineAdrenergicβ2Homo sapiensFAUC50--3.52011-01-12doi.org/10.1038/nature09665
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-19doi.org/10.1038/nature09648
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.22011-07-20doi.org/10.1038/nature10361
3SN6 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.22011-07-20doi.org/10.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiensCarazolol--3.992012-10-24doi.org/10.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-25doi.org/10.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzyl Isoproterenol--3.12013-09-25doi.org/10.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22013-09-25doi.org/10.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-23doi.org/10.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiensCarazolol--2.482016-01-13doi.org/10.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiensCarazolol--3.82016-01-13doi.org/10.1107/S2059798315021683
5JQHAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-07-13doi.org/10.1038/nature18636
5D6LAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-08-17doi.org/10.1038/nprot.2017.057
5X7DAAmineAdrenergicβ2Homo sapiensCarazololPubChem 129318963-2.72017-08-16doi.org/10.1038/nature23652
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-14doi.org/10.1038/s41589-018-0145-x
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs(CT)3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6E67 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-26doi.org/10.1126/science.aaw8981
6PRZAAmineAdrenergicβ2Homo sapiensAlprenolol--2.82019-11-13doi.org/10.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiensCarazolol--3.42019-11-13doi.org/10.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-13doi.org/10.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiensAlprenolol--2.42019-11-13doi.org/10.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiensCarvedilol--2.52019-11-13doi.org/10.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI118-551--2.62019-11-13doi.org/10.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiensPropranolol--2.92019-11-13doi.org/10.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-13doi.org/10.1107/S2052252519013137
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.82019-11-20doi.org/10.1038/s41594-019-0330-y
6NI3 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.82019-11-20doi.org/10.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiensAlprenololGTPL11074-3.12020-03-25doi.org/10.1038/s41589-020-0549-2
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/β1/γ23.822020-08-05doi.org/10.1038/s41421-020-0176-9
7BZ2 (No Gprot) AAmineAdrenergicβ2Homo sapiensArformoterol-3.822020-08-05doi.org/10.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/β1/γ23.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHI (No Gprot) AAmineAdrenergicβ2Homo sapiensSalbutamol-3.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/β1/γ23.82020-12-16doi.org/10.1093/nsr/nwaa284
7DHR (No Gprot) AAmineAdrenergicβ2Homo sapiensIsoprenaline-3.82020-12-16doi.org/10.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.12023-04-26doi.org/10.1038/s41467-023-37808-y
8JJ8AAmineAdrenergicβ2Homo sapiensArformoterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-06doi.org/10.1038/s41589-023-01389-0
8GE2AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.22024-03-06doi.org/10.1038/s41586-024-07153-1
9CHUAAmineAdrenergicβ2Homo sapiensNorepinephrine--3.492024-11-13doi.org/10.1073/pnas.2414544121
9U9VAAmineAdrenergicβ2Homo sapiensMETH-Gs/β1/γ22.852025-09-03To be published
9U9V (No Gprot) AAmineAdrenergicβ2Homo sapiensMETH-2.852025-09-03To be published
7XK9AAmineAdrenergicβ2Homo sapiensConstrained IsoproterenolNa-3.42023-04-26doi.org/10.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GDZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GEB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GED (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEG (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8GEH (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-42024-03-06doi.org/10.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEI (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ22.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP2.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--42024-03-06doi.org/10.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8UNLAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNL (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNM (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNN (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNO (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNP (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNR (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNS (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNT (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNU (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg42024-03-06doi.org/10.1038/s41586-024-07153-1
8W1VAAmineAdrenergicβ2Homo sapiensPubChem 171716265--32024-07-17doi.org/10.1021/acs.jmedchem.4c00578
9CHXAAmineAdrenergicβ2Homo sapiensCarazolol--3.52024-11-13doi.org/10.1073/pnas.2414544121
9BUYAAmineAdrenergicβ2Homo sapiensLM189-Gi1/β1/γ22.92025-05-28doi.org/10.1126/sciadv.adq3971
9BUY (No Gprot) AAmineAdrenergicβ2Homo sapiensLM189-2.92025-05-28doi.org/10.1126/sciadv.adq3971
9M55AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-chim(NtGi1-Gs)/β1/γ23.392025-12-1710.1093/pnasnexus/pgaf376
9M55 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-3.392025-12-1710.1093/pnasnexus/pgaf376
9M57AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-chim(NtGi1-Gs)/β1/γ23.652025-12-1710.1093/pnasnexus/pgaf376
9M57 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-3.652025-12-1710.1093/pnasnexus/pgaf376
9L8LAAmineAdrenergicβ2Homo sapiensBI167107AtazanavirGs/β1/γ2 ; Arrestin23.222025-12-31To be published
9L8L (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107Atazanavir3.222025-12-31To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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