psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V33	R:R:W32	15.94	No	No	0	4	3
2	R:R:I38	R:R:V34	3.07	No	No	0	5	5
3	R:R:G35	R:R:I38	3.53	No	No	0	5	5
4	R:R:I94	R:R:M36	7.29	No	No	0	5	5
5	R:R:I38	R:R:S41	3.1	No	No	0	5	4
6	R:R:I43	R:R:V39	3.07	Yes	No	0	6	5
7	R:R:I43	R:R:M40	7.29	Yes	Yes	0	6	6
8	R:R:M40	R:R:V44	3.04	Yes	No	0	6	6
9	R:R:M40	R:R:V87	3.04	Yes	No	0	6	7
10	R:R:A91	R:R:M40	3.22	No	Yes	0	6	6
11	R:R:M40	R:R:W313	3.49	Yes	Yes	0	6	5
12	R:R:I43	R:R:Y316	19.34	Yes	No	0	6	6
13	R:R:P88	R:R:V44	7.07	No	No	0	8	6
14	R:R:D79	R:R:I47	2.8	No	No	0	9	8
15	R:R:G83	R:R:I47	3.53	No	No	0	7	8
16	R:R:G320	R:R:I47	3.53	No	No	0	7	8
17	R:R:L84	R:R:V48	4.47	No	No	0	5	6
18	R:R:G50	R:R:P323	4.06	No	No	0	8	9
19	R:R:A76	R:R:N51	4.69	No	No	0	9	9
20	R:R:D79	R:R:N51	14.81	No	No	0	9	9
21	R:R:L80	R:R:N51	9.61	No	No	0	7	9
22	R:R:F336	R:R:L53	12.18	No	No	0	7	6
23	R:R:V54	R:R:Y326	2.52	No	Yes	0	9	9
24	R:R:I55	R:R:T73	3.04	No	No	0	7	6
25	R:R:C77	R:R:I55	3.27	No	No	0	6	7
26	R:R:I58	R:R:N69	5.66	Yes	Yes	0	7	9
27	R:R:I58	R:R:T73	7.6	Yes	No	0	7	6
28	R:R:F61	R:R:K60	6.2	Yes	No	1	6	5
29	R:R:E338	R:R:K60	4.05	No	No	1	4	5
30	R:R:F61	R:R:R63	6.41	Yes	No	1	6	6
31	R:R:F61	R:R:L64	2.44	Yes	Yes	1	6	8
32	R:R:E338	R:R:F61	4.66	No	Yes	1	4	6
33	R:R:L64	R:R:R63	4.86	Yes	No	1	8	6
34	R:R:D331	R:R:R63	10.72	No	No	1	7	6
35	R:R:L64	R:R:N69	5.49	Yes	Yes	1	8	9
36	R:R:D331	R:R:L64	6.79	No	Yes	1	7	8
37	R:R:F332	R:R:L64	4.87	Yes	Yes	1	9	8
38	R:R:Q65	R:R:Y70	7.89	No	Yes	3	8	4
39	R:R:K147	R:R:Q65	4.07	No	No	3	1	8
40	R:R:N69	R:R:T66	2.92	Yes	No	0	9	7
41	R:R:V67	R:R:Y141	6.31	No	No	0	6	7
42	R:R:R131	R:R:T68	6.47	Yes	No	0	9	8
43	R:R:I72	R:R:N69	2.83	No	Yes	0	8	9
44	R:R:F332	R:R:N69	8.46	Yes	Yes	1	9	9
45	R:R:K147	R:R:Y70	9.55	No	Yes	3	1	4
46	R:R:R151	R:R:Y70	26.75	No	Yes	3	3	4
47	R:R:F71	R:R:V126	5.24	Yes	No	2	8	7
48	R:R:F71	R:R:I127	2.51	Yes	Yes	0	8	9
49	R:R:F71	R:R:I153	6.28	Yes	No	2	8	6
50	R:R:F71	R:R:I154	2.51	Yes	No	2	8	8
51	R:R:I127	R:R:I72	2.94	Yes	No	0	9	8
52	R:R:I72	R:R:Y326	13.3	No	Yes	0	8	9
53	R:R:S74	R:R:T123	6.4	No	No	0	9	8
54	R:R:I154	R:R:S74	6.19	No	No	2	8	9
55	R:R:S74	R:R:W158	8.65	No	No	2	9	9
56	R:R:L75	R:R:S120	4.5	No	No	0	9	9
57	R:R:L124	R:R:L75	2.77	No	No	0	8	9
58	R:R:L75	R:R:N322	6.87	No	No	0	9	9
59	R:R:A78	R:R:W158	5.19	No	No	0	8	9
60	R:R:D79	R:R:S319	10.31	No	No	0	9	9
61	R:R:C116	R:R:V81	3.42	No	No	0	7	7
62	R:R:M82	R:R:V86	4.56	No	Yes	0	7	7
63	R:R:C116	R:R:M82	8.1	No	No	0	7	7
64	R:R:M82	R:R:S319	3.07	No	No	0	7	9
65	R:R:V86	R:R:W109	7.36	Yes	Yes	0	7	5
66	R:R:I112	R:R:V86	6.14	No	Yes	0	4	7
67	R:R:P88	R:R:V87	8.84	No	No	0	8	7
68	R:R:F89	R:R:W99	4.01	No	Yes	0	5	7
69	R:R:G90	R:R:W109	5.63	No	Yes	0	7	5
70	R:R:A92	R:R:W99	7.78	No	Yes	0	4	7
71	R:R:D192	R:R:H93	8.82	No	No	0	3	4
72	R:R:I94	R:R:L95	2.85	No	No	0	5	6
73	R:R:L95	R:R:M96	4.24	No	No	0	6	4
74	R:R:T100	R:R:W99	3.64	No	Yes	0	2	7
75	R:R:F101	R:R:W99	8.02	No	Yes	0	5	7
76	R:R:C106	R:R:W99	2.61	No	Yes	5	9	7
77	R:R:C191	R:R:W99	2.61	No	Yes	5	9	7
78	R:R:F104	R:R:W105	8.02	No	No	0	1	5
79	R:R:F108	R:R:W105	13.03	No	No	0	5	5
80	R:R:C106	R:R:C191	5.46	No	No	5	9	9
81	R:R:E107	R:R:H172	12.31	No	No	6	5	4
82	R:R:E107	R:R:Y174	6.73	No	No	6	5	5
83	R:R:F108	R:R:F166	6.43	No	No	0	5	4
84	R:R:T110	R:R:W109	2.43	No	Yes	0	4	5
85	R:R:D113	R:R:T110	2.89	No	No	0	7	4
86	R:R:I169	R:R:T110	3.04	No	No	0	5	4
87	R:R:F166	R:R:S111	10.57	No	No	7	4	6
88	R:R:I169	R:R:S111	7.74	No	No	7	5	6
89	R:R:D113	R:R:V114	5.84	No	No	0	7	5
90	R:R:L115	R:R:S161	3	Yes	No	0	5	8
91	R:R:G162	R:R:L115	6.84	No	Yes	0	4	5
92	R:R:L115	R:R:S165	3	Yes	No	0	5	7
93	R:R:V117	R:R:W286	8.58	No	No	0	6	8
94	R:R:S161	R:R:T118	7.99	No	No	0	8	6
95	R:R:S207	R:R:T118	9.59	No	No	0	5	6
96	R:R:F208	R:R:I121	2.51	Yes	Yes	4	8	7
97	R:R:I121	R:R:P211	10.16	Yes	No	0	7	8
98	R:R:I121	R:R:L212	2.85	Yes	Yes	4	7	7
99	R:R:F282	R:R:I121	11.3	No	Yes	4	9	7
100	R:R:E122	R:R:V157	7.13	No	No	0	5	7
101	R:R:E122	R:R:S161	7.19	No	No	0	5	8
102	R:R:I278	R:R:L124	4.28	No	No	0	8	8
103	R:R:L124	R:R:M279	2.83	No	Yes	0	8	8
104	R:R:C125	R:R:M215	3.24	No	No	0	7	8
105	R:R:I153	R:R:V126	4.61	No	No	2	6	7
106	R:R:I127	R:R:L275	2.85	Yes	No	0	9	8
107	R:R:I127	R:R:M279	2.92	Yes	Yes	0	9	8
108	R:R:A128	R:R:Y219	2.67	No	Yes	8	8	9
109	R:R:A128	R:R:M279	3.22	No	Yes	8	8	8
110	R:R:D130	R:R:V129	2.92	No	No	0	8	6
111	R:R:V129	R:R:V218	6.41	No	No	0	6	6
112	R:R:D130	R:R:R131	3.57	No	Yes	0	8	9
113	R:R:L272	R:R:R131	2.43	No	Yes	0	7	9
114	R:R:F133	R:R:Y132	4.13	No	Yes	0	5	8
115	R:R:T136	R:R:Y132	9.99	No	Yes	9	7	8
116	R:R:R221	R:R:Y132	10.29	No	Yes	0	5	8
117	R:R:V222	R:R:Y132	5.05	No	Yes	0	8	8
118	R:R:E225	R:R:Y132	5.61	No	Yes	9	5	8
119	R:R:A134	R:R:Y141	9.34	No	No	0	8	7
120	R:R:I135	R:R:V222	4.61	Yes	No	0	9	8
121	R:R:E268	R:R:I135	5.47	Yes	Yes	0	7	9
122	R:R:H269	R:R:I135	7.95	Yes	Yes	0	5	9
123	R:R:S137	R:R:T136	4.8	No	No	0	6	7
124	R:R:E225	R:R:T136	4.23	No	No	9	5	7
125	R:R:P138	R:R:Q142	4.74	No	No	0	8	4
126	R:R:E268	R:R:P138	7.86	Yes	No	0	7	8
127	R:R:F139	R:R:K140	2.48	No	No	0	6	5
128	R:R:F139	R:R:Q142	10.54	No	No	0	6	4
129	R:R:K149	R:R:L145	8.46	No	No	0	5	7
130	R:R:K149	R:R:T146	6.01	No	No	0	5	8
131	R:R:K147	R:R:R151	3.71	No	No	3	1	3
132	R:R:I154	R:R:W158	5.87	No	No	2	8	9
133	R:R:M156	R:R:V160	4.56	No	No	0	4	4
134	R:R:L163	R:R:L167	2.77	No	No	0	4	5
135	R:R:F166	R:R:I169	7.54	No	No	7	4	5
136	R:R:L167	R:R:P168	3.28	No	No	0	5	5
137	R:R:P168	R:R:Y199	18.08	No	Yes	0	5	6
138	R:R:H172	R:R:Y174	11.98	No	No	6	4	5
139	R:R:T195	R:R:Y174	2.5	No	No	0	3	5
140	R:R:D192	R:R:F194	5.97	No	No	0	3	1
141	R:R:T195	R:R:Y199	2.5	No	Yes	0	3	6
142	R:R:N196	R:R:Q197	3.96	No	No	0	4	2
143	R:R:A202	R:R:Y199	2.67	No	Yes	0	4	6
144	R:R:S203	R:R:Y199	8.9	No	Yes	0	5	6
145	R:R:I201	R:R:I205	2.94	No	No	0	5	4
146	R:R:I201	R:R:I294	2.94	No	Yes	0	5	6
147	R:R:I294	R:R:S204	4.64	Yes	No	0	6	5
148	R:R:F208	R:R:L212	4.87	Yes	Yes	4	8	7
149	R:R:F208	R:R:F282	4.29	Yes	No	4	8	9
150	R:R:F208	R:R:L287	7.31	Yes	No	0	8	6
151	R:R:F208	R:R:F290	13.93	Yes	No	0	8	7
152	R:R:P211	R:R:V210	3.53	No	No	0	8	5
153	R:R:L212	R:R:M215	2.83	Yes	No	0	7	8
154	R:R:L212	R:R:T283	10.32	Yes	No	0	7	7
155	R:R:M215	R:R:M279	2.89	No	Yes	0	8	8
156	R:R:F217	R:R:R221	5.34	No	No	0	4	5
157	R:R:F223	R:R:Y219	4.13	No	Yes	0	6	9
158	R:R:G276	R:R:Y219	4.35	No	Yes	0	6	9
159	R:R:M279	R:R:Y219	7.18	Yes	Yes	8	8	9
160	R:R:Q224	R:R:R221	4.67	No	No	0	3	5
161	R:R:K227	R:R:L230	7.05	No	No	0	6	5
162	R:R:H269	R:R:Q229	6.18	Yes	No	0	5	7
163	R:R:H269	R:R:L230	3.86	Yes	No	0	5	5
164	R:R:F264	R:R:L266	2.44	No	No	0	4	5
165	R:R:C265	R:R:K267	3.23	No	No	0	3	6
166	R:R:H269	R:R:L266	6.43	Yes	No	0	5	5
167	R:R:I277	R:R:I325	2.94	No	No	0	7	8
168	R:R:I278	R:R:Y326	3.63	No	Yes	0	8	9
169	R:R:F282	R:R:N318	6.04	No	Yes	0	9	9
170	R:R:G315	R:R:W286	9.85	No	No	0	7	8
171	R:R:N318	R:R:W286	7.91	Yes	No	0	9	8
172	R:R:L287	R:R:P288	3.28	No	No	0	6	9
173	R:R:I291	R:R:L287	8.56	No	No	0	6	6
174	R:R:F289	R:R:Y308	9.28	No	Yes	0	6	5
175	R:R:F289	R:R:N312	14.5	No	No	0	6	5
176	R:R:F290	R:R:N293	6.04	No	No	0	7	5
177	R:R:V292	R:R:Y308	2.52	No	Yes	0	5	5
178	R:R:I294	R:R:N293	2.83	Yes	No	0	6	5
179	R:R:N293	R:R:Y308	4.65	No	Yes	0	5	5
180	R:R:I294	R:R:V297	3.07	Yes	No	0	6	5
181	R:R:H296	R:R:N301	7.65	No	No	0	3	2
182	R:R:H296	R:R:Y308	14.16	No	Yes	0	3	5
183	R:R:I298	R:R:Q299	2.74	No	No	0	4	2
184	R:R:D300	R:R:I298	7	No	No	0	1	4
185	R:R:L302	R:R:R304	3.64	No	No	0	1	4
186	R:R:I303	R:R:R304	5.01	No	No	0	3	4
187	R:R:R304	R:R:V307	6.54	No	No	0	4	4
188	R:R:E306	R:R:L310	13.25	No	No	0	2	5
189	R:R:L310	R:R:V307	8.94	No	No	0	5	4
190	R:R:I309	R:R:N312	4.25	No	No	0	3	5
191	R:R:I309	R:R:W313	3.52	No	Yes	0	3	5
192	R:R:I314	R:R:L311	5.71	No	No	0	7	5
193	R:R:W313	R:R:Y316	16.4	Yes	No	0	5	6
194	R:R:G315	R:R:I314	3.53	No	No	0	7	7
195	R:R:V317	R:R:Y316	13.88	No	No	0	5	6
196	R:R:N318	R:R:S319	2.98	Yes	No	0	9	9
197	R:R:N318	R:R:N322	5.45	Yes	No	0	9	9
198	R:R:F321	R:R:L324	10.96	No	No	0	6	6
199	R:R:P323	R:R:Y326	2.78	No	Yes	0	9	9
200	R:R:F332	R:R:Y326	4.13	Yes	Yes	0	9	9
201	R:R:C327	R:R:F336	2.79	No	No	0	7	7
202	R:R:P330	R:R:S329	3.56	No	No	0	5	8
203	R:R:F332	R:R:S329	5.28	Yes	No	0	9	8
204	R:R:I334	R:R:Q337	2.74	No	No	0	4	4
205	R:R:E338	R:R:I334	4.1	No	No	0	4	4
206	R:R:I58	R:R:Y70	2.42	Yes	Yes	0	7	4
207	R:R:I291	R:R:Y209	2.42	No	No	0	6	5
208	R:R:I94	R:R:W313	2.35	No	Yes	0	5	5
209	R:R:M171	R:R:W173	2.33	No	No	0	4	4
210	R:R:R131	R:R:Y141	2.06	Yes	No	0	9	7
211	R:R:F89	R:R:W109	2	No	Yes	0	5	5
212	R:R:G280	R:R:T283	1.82	No	No	0	5	7
213	R:R:A335	R:R:A57	1.79	No	No	0	7	8
214	R:R:G37	R:R:M36	1.75	No	No	0	5	5
215	R:R:A85	R:R:V86	1.7	No	Yes	0	4	7
216	R:R:A128	R:R:V218	1.7	No	No	0	8	6
217	R:R:A200	R:R:V297	1.7	No	No	0	5	5
218	R:R:A200	R:R:T195	1.68	No	No	0	5	3
219	R:R:C285	R:R:I314	1.64	No	No	0	9	7
220	R:R:A59	R:R:I58	1.62	No	Yes	0	4	7
221	R:R:S165	R:R:V114	1.62	No	No	0	7	5
222	R:R:A226	R:R:I135	1.62	No	Yes	0	8	9
223	R:R:A150	R:R:I153	1.62	No	No	0	7	6
224	R:R:S207	R:R:V206	1.62	No	No	0	5	4
225	R:R:V44	R:R:V48	1.6	No	No	0	6	6
226	R:R:V48	R:R:V52	1.6	No	No	0	6	3
227	R:R:V292	R:R:V307	1.6	No	No	0	5	4
228	R:R:T56	R:R:V52	1.59	No	No	0	5	3
229	R:R:C327	R:R:L324	1.59	No	No	0	7	6
230	R:R:A119	R:R:L115	1.58	No	Yes	0	7	5
231	R:R:I159	R:R:V160	1.54	No	No	0	4	4
232	R:R:I214	R:R:V213	1.54	No	No	0	6	4
233	R:R:I294	R:R:V295	1.54	Yes	No	0	6	4
234	R:R:I298	R:R:V295	1.54	No	No	0	4	4
235	R:R:F49	R:R:G50	1.51	No	No	0	4	8
236	R:R:A134	R:R:E268	1.51	No	Yes	0	8	7
237	R:R:L275	R:R:T274	1.47	No	No	0	8	8
238	R:R:I278	R:R:I325	1.47	No	No	0	8	8
239	R:R:N148	R:R:T146	1.46	No	No	0	4	8
240	R:R:I43	R:R:L42	1.43	Yes	No	0	6	5
241	R:R:E122	R:R:V160	1.43	No	No	0	5	4
242	R:R:I159	R:R:L155	1.43	No	No	0	4	3
243	R:R:Q197	R:R:V297	1.43	No	No	0	2	5
244	R:R:L144	R:R:L145	1.38	No	No	0	4	7
245	R:R:P168	R:R:W173	1.35	No	No	0	5	4
246	R:R:E268	R:R:K267	1.35	Yes	No	0	7	6
247	R:R:A198	R:R:W173	1.3	No	No	0	4	4
248	R:R:F193	R:R:Y199	1.03	No	Yes	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M40	4.016	5	0	6
2	R:R:I43	7.7825	4	0	6
3	R:R:I58	4.325	4	0	7
4	R:R:F61	4.9275	4	1	6
5	R:R:L64	4.89	5	1	8
6	R:R:N69	5.072	5	1	9
7	R:R:Y70	11.6525	4	3	4
8	R:R:F71	4.135	4	2	8
9	R:R:V86	4.94	4	0	7
10	R:R:W99	4.77833	6	5	7
11	R:R:W109	4.355	4	0	5
12	R:R:L115	3.605	4	0	5
13	R:R:I121	6.705	4	4	7
14	R:R:I127	2.805	4	0	9
15	R:R:R131	3.6325	4	0	9
16	R:R:Y132	7.014	5	9	8
17	R:R:I135	4.9125	4	0	9
18	R:R:Y199	6.636	5	0	6
19	R:R:F208	6.582	5	4	8
20	R:R:L212	5.2175	4	4	7
21	R:R:Y219	4.5825	4	8	9
22	R:R:E268	4.0475	4	0	7
23	R:R:H269	6.105	4	0	5
24	R:R:M279	3.808	5	8	8
25	R:R:I294	3.004	5	0	6
26	R:R:Y308	7.6525	4	0	5
27	R:R:W313	6.44	4	0	5
28	R:R:N318	5.595	4	0	9
29	R:R:Y326	5.272	5	0	9
30	R:R:F332	5.685	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M40	R:R:W313	25.5011	3.49	Yes	Yes	0	6	5
2	R:R:I94	R:R:W313	10.2139	2.35	No	Yes	0	5	5
3	R:R:W313	R:R:Y316	10.2522	16.4	Yes	No	0	5	6
4	R:R:M40	R:R:V44	12.4197	3.04	Yes	No	0	6	6
5	R:R:D79	R:R:S319	15.9682	10.31	No	No	0	9	9
6	R:R:N318	R:R:S319	87.1775	2.98	Yes	No	0	9	9
7	R:R:F282	R:R:N318	44.8355	6.04	No	Yes	0	9	9
8	R:R:F208	R:R:F282	41.3158	4.29	Yes	No	4	8	9
9	R:R:F208	R:R:F290	100	13.93	Yes	No	0	8	7
10	R:R:F290	R:R:N293	99.0505	6.04	No	No	0	7	5
11	R:R:N293	R:R:Y308	66.347	4.65	No	Yes	0	5	5
12	R:R:F289	R:R:Y308	50.7145	9.28	No	Yes	0	6	5
13	R:R:F289	R:R:N312	48.9978	14.5	No	No	0	6	5
14	R:R:I309	R:R:N312	47.4921	4.25	No	No	0	3	5
15	R:R:I309	R:R:W313	45.737	3.52	No	Yes	0	3	5
16	R:R:I72	R:R:Y326	17.4163	13.3	No	Yes	0	8	9
17	R:R:I127	R:R:I72	44.5478	2.94	Yes	No	0	9	8
18	R:R:I127	R:R:M279	61.2065	2.92	Yes	Yes	0	9	8
19	R:R:M215	R:R:M279	69.6461	2.89	No	Yes	0	8	8
20	R:R:L212	R:R:M215	71.334	2.83	Yes	No	0	7	8
21	R:R:F208	R:R:L212	67.6992	4.87	Yes	Yes	4	8	7
22	R:R:I278	R:R:Y326	31.4952	3.63	No	Yes	0	8	9
23	R:R:I278	R:R:L124	35.2354	4.28	No	No	0	8	8
24	R:R:L124	R:R:M279	46.7057	2.83	No	Yes	0	8	8
25	R:R:I58	R:R:N69	28.2632	5.66	Yes	Yes	0	7	9
26	R:R:I72	R:R:N69	39.8293	2.83	No	Yes	0	8	9
27	R:R:F61	R:R:L64	10.0125	2.44	Yes	Yes	1	6	8
28	R:R:L64	R:R:N69	10.6934	5.49	Yes	Yes	1	8	9
29	R:R:F332	R:R:Y326	20.7826	4.13	Yes	Yes	0	9	9
30	R:R:I58	R:R:Y70	12.5539	2.42	Yes	Yes	0	7	4
31	R:R:A128	R:R:M279	61.312	3.22	No	Yes	8	8	8
32	R:R:A128	R:R:V218	60.7365	1.7	No	No	0	8	6
33	R:R:V129	R:R:V218	59.1637	6.41	No	No	0	6	6
34	R:R:D130	R:R:V129	57.5717	2.92	No	No	0	8	6
35	R:R:D130	R:R:R131	55.9605	3.57	No	Yes	0	8	9
36	R:R:R131	R:R:Y141	51.242	2.06	Yes	No	0	9	7
37	R:R:F71	R:R:I127	18.548	2.51	Yes	Yes	0	8	9
38	R:R:F71	R:R:I154	10.492	2.51	Yes	No	2	8	8
39	R:R:N318	R:R:N322	56.8908	5.45	Yes	No	0	9	9
40	R:R:L75	R:R:N322	56.6606	6.87	No	No	0	9	9
41	R:R:M82	R:R:S319	74.825	3.07	No	No	0	7	9
42	R:R:M82	R:R:V86	69.8763	4.56	No	Yes	0	7	7
43	R:R:F89	R:R:W109	15.9682	2	No	Yes	0	5	5
44	R:R:V86	R:R:W109	64.7262	7.36	Yes	Yes	0	7	5
45	R:R:F89	R:R:W99	13.7432	4.01	No	Yes	0	5	7
46	R:R:I169	R:R:T110	13.5034	3.04	No	No	0	5	4
47	R:R:T110	R:R:W109	48.7197	2.43	No	Yes	0	4	5
48	R:R:A200	R:R:T195	28.2823	1.68	No	No	0	5	3
49	R:R:A200	R:R:V297	30.1908	1.7	No	No	0	5	5
50	R:R:I294	R:R:V297	35.5711	3.07	Yes	No	0	6	5
51	R:R:I294	R:R:N293	49.6883	2.83	Yes	No	0	6	5
52	R:R:D113	R:R:T110	35.1012	2.89	No	No	0	7	4
53	R:R:D113	R:R:V114	33.0776	5.84	No	No	0	7	5
54	R:R:S165	R:R:V114	31.006	1.62	No	No	0	7	5
55	R:R:L115	R:R:S165	28.9153	3	Yes	No	0	5	7
56	R:R:L115	R:R:S161	22.5281	3	Yes	No	0	5	8
57	R:R:N318	R:R:W286	13.7432	7.91	Yes	No	0	9	8
58	R:R:E122	R:R:S161	13.7432	7.19	No	No	0	5	8
59	R:R:V222	R:R:Y132	16.9464	5.05	No	Yes	0	8	8
60	R:R:I135	R:R:V222	18.9124	4.61	Yes	No	0	9	8
61	R:R:E268	R:R:I135	33.8832	5.47	Yes	Yes	0	7	9
62	R:R:A134	R:R:E268	46.2837	1.51	No	Yes	0	8	7
63	R:R:A134	R:R:Y141	48.01	9.34	No	No	0	8	7
64	R:R:H269	R:R:I135	12.3238	7.95	Yes	Yes	0	5	9
65	R:R:T195	R:R:Y199	20.6579	2.5	No	Yes	0	3	6
66	R:R:P168	R:R:Y199	12.7649	18.08	No	Yes	0	5	6
67	R:R:V292	R:R:Y308	14.7885	2.52	No	Yes	0	5	5
68	R:R:V292	R:R:V307	12.7553	1.6	No	No	0	5	4
69	R:R:F332	R:R:N69	10.6167	8.46	Yes	Yes	1	9	9
70	R:R:L124	R:R:L75	56.3153	2.77	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9CHV

PDB Summary
PDB	9CHV
Class	A
SubFamily	Amine
Type	Adrenergic
SubType	Beta2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.95
Date	2024-11-13
D.O.I.	doi.org/10.1073/pnas.2414544121

Net Summary
I_min	2.43
Number of Linked Nodes	236
Number of Links	248
Number of Hubs	30
Number of Links mediated by Hubs	113
Number of Communities	9
Number of Nodes involved in Communities	37
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	25926
Length Of Smallest Path	3
Average Path Length	14.0478
Length of Longest Path	32
Minimum Path Strength	1.325
Average Path Strength	4.98226
Maximum Path Strength	17.87
Minimum Path Correlation	0.7
Average Path Correlation	0.925023
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.8264
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.7948
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• isomerase activity • catalytic activity, acting on a protein • peptidyl-prolyl cis-trans isomerase activity • catalytic activity • cis-trans isomerase activity • transforming growth factor beta receptor binding • protein binding • binding • signaling receptor binding • type I transforming growth factor beta receptor binding • cytokine receptor binding • FK506 binding • amide binding • macrolide binding • activin receptor binding • receptor serine/threonine kinase binding • transmembrane receptor protein serine/threonine kinase binding • channel regulator activity • ion channel regulator activity • calcium channel regulator activity • molecular function regulator activity • transporter regulator activity • transmembrane transporter binding • SMAD binding • I-SMAD binding • molecular function inhibitor activity • signaling receptor inhibitor activity • signaling receptor regulator activity • protein refolding • primary metabolic process • gene expression • macromolecule biosynthetic process • protein maturation • protein folding • biosynthetic process • metabolic process • cellular process • protein metabolic process • macromolecule metabolic process • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process
Gene Ontology	Biological Process	• protein refolding • primary metabolic process • gene expression • macromolecule biosynthetic process • protein maturation • protein folding • biosynthetic process • metabolic process • cellular process • protein metabolic process • macromolecule metabolic process • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • positive regulation of canonical NF-kappaB signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • biological regulation • positive regulation of intracellular signal transduction • canonical NF-kappaB signal transduction • regulation of response to stimulus • regulation of cell communication • regulation of canonical NF-kappaB signal transduction • positive regulation of signaling • activin receptor signaling pathway • cell surface receptor protein serine/threonine kinase signaling pathway • negative regulation of signaling • regulation of transmembrane receptor protein serine/threonine kinase signaling pathway • negative regulation of biological process • negative regulation of cell communication • negative regulation of activin receptor signaling pathway • negative regulation of cellular process • enzyme-linked receptor protein signaling pathway • cell surface receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • transforming growth factor beta receptor superfamily signaling pathway • regulation of activin receptor signaling pathway • negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway • cellular component organization • cellular component organization or biogenesis • supramolecular fiber organization • amyloid fibril formation • regulation of calcium ion transport • regulation of localization • intracellular calcium ion homeostasis • calcium ion transport • localization • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of molecular function • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • regulation of transmembrane transporter activity • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • monoatomic ion transport • intracellular chemical homeostasis • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • regulation of ryanodine-sensitive calcium-release channel activity • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • amyloid precursor protein catabolic process • regulation of protein metabolic process • regulation of amyloid precursor protein catabolic process • regulation of macromolecule metabolic process • regulation of primary metabolic process • amyloid precursor protein metabolic process • regulation of metabolic process • immune response • immune system process • regulation of immune response • regulation of immune system process • developmental process • heart development • multicellular organismal process • cardiac chamber morphogenesis • heart trabecula formation • animal organ development • heart morphogenesis • circulatory system development • anatomical structure morphogenesis • multicellular organism development • anatomical structure development • anatomical structure formation involved in morphogenesis • cardiac chamber development • animal organ morphogenesis • heart trabecula morphogenesis • trabecula formation • trabecula morphogenesis • system development • T cell activation • cell activation • lymphocyte activation • leukocyte activation • negative regulation of transforming growth factor beta receptor signaling pathway • cellular response to growth factor stimulus • cellular response to transforming growth factor beta stimulus • regulation of transforming growth factor beta receptor signaling pathway • cellular response to endogenous stimulus • regulation of cellular response to transforming growth factor beta stimulus • response to endogenous stimulus • regulation of cellular response to growth factor stimulus • response to transforming growth factor beta • transforming growth factor beta receptor signaling pathway • response to growth factor • regulation of protein localization • macromolecule localization • intracellular protein localization • 'de novo' protein folding • system process • regulation of system process • sarcoplasmic reticulum calcium ion transport • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • multicellular organismal movement • regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion • regulation of skeletal muscle contraction by calcium ion signaling • release of sequestered calcium ion into cytosol by endoplasmic reticulum • skeletal muscle contraction • muscle contraction • regulation of striated muscle contraction • regulation of muscle contraction • calcium-mediated signaling • striated muscle contraction • musculoskeletal movement • regulation of skeletal muscle contraction • regulation of multicellular organismal process • nervous system process • neuromuscular process • muscle system process • regulation of muscle system process • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • ventricular cardiac muscle tissue morphogenesis • striated muscle tissue development • muscle structure development • ventricular cardiac muscle tissue development • muscle tissue development • muscle organ development • cardiac muscle tissue development • tissue development • muscle tissue morphogenesis • tissue morphogenesis • cardiac ventricle morphogenesis • cardiac muscle tissue morphogenesis • cardiac ventricle development • muscle organ morphogenesis • membrane-bounded organelle • intracellular anatomical structure • organelle subcompartment • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • intracellular organelle • endoplasmic reticulum subcompartment • terminal cisterna • cellular anatomical structure • organelle • endoplasmic reticulum • sarcoplasmic reticulum • cytoplasm
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • organelle subcompartment • intracellular membrane-bounded organelle • endomembrane system • sarcoplasm • intracellular organelle • endoplasmic reticulum subcompartment • terminal cisterna • cellular anatomical structure • organelle • endoplasmic reticulum • sarcoplasmic reticulum • cytoplasm • membrane • intracellular membraneless organelle • Z disc • sarcomere • I band • membraneless organelle • contractile muscle fiber • supramolecular fiber • myofibril • supramolecular polymer • supramolecular complex • bounding membrane of organelle • nuclear outer membrane-endoplasmic reticulum membrane network • sarcoplasmic reticulum membrane • organelle membrane • endoplasmic reticulum membrane • cytoplasmic side of membrane • side of membrane • cytosol • protein-containing complex • membrane protein complex • ryanodine receptor complex • transporter complex • cell periphery • endoplasmic reticulum protein-containing complex • plasma membrane protein complex • voltage-gated calcium channel complex • plasma membrane • cation channel complex • transmembrane transporter complex • calcium channel complex • monoatomic ion channel complex • phosphoric ester hydrolase activity • phosphoprotein phosphatase activity • catalytic activity, acting on a protein • hydrolase activity, acting on ester bonds • phosphatase activity • hydrolase activity • catalytic activity • protein binding • binding • calmodulin binding • protein dimerization activity • cation binding • ion binding • metal ion binding • small molecule binding • ATPase binding • enzyme binding • protein serine/threonine phosphatase activity • calmodulin-dependent protein phosphatase activity • calcium-dependent protein serine/threonine phosphatase activity • calcineurin-NFAT signaling cascade • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • cellular process • signal transduction • calcineurin-mediated signaling • regulation of signaling • negative regulation of signaling • negative regulation of biological process • multicellular organismal process • renal system process • system process • renal filtration • response to metal ion • response to chemical • response to calcium ion • developmental process • regulation of developmental process • animal organ development • positive regulation of biological process • regulation of kidney development • positive regulation of glomerulus development • positive regulation of kidney development • renal system development • positive regulation of developmental process • glomerulus development • multicellular organism development • regulation of glomerulus development • anatomical structure development • positive regulation of multicellular organismal process • regulation of multicellular organismal process • nephron development • kidney development • system development • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • protein dephosphorylation • dephosphorylation • primary metabolic process • macromolecule modification • phosphate-containing compound metabolic process • protein metabolic process • protein modification process • phosphorus metabolic process • regulation of calcium ion transport • regulation of localization • import into cell • transport • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • negative regulation of transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • negative regulation of transmembrane transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • localization • negative regulation of monoatomic ion transmembrane transport • negative regulation of cellular process • monoatomic ion transport • negative regulation of cation transmembrane transport • negative regulation of calcium ion import across plasma membrane • calcium ion import into cytosol • monoatomic cation transport • regulation of metal ion transport • regulation of calcium ion import • calcium ion transmembrane import into cytosol • regulation of transport • regulation of monoatomic ion transport • import across plasma membrane • establishment of localization • inorganic cation import across plasma membrane • negative regulation of calcium ion import • negative regulation of calcium ion transport • transmembrane transport • regulation of transmembrane transport • calcium ion import across plasma membrane • regulation of calcium ion import across plasma membrane • inorganic ion import across plasma membrane • regulation of monoatomic cation transmembrane transport • calcium ion import • negative regulation of calcium ion transmembrane transport • calcium ion transmembrane transport • establishment of protein localization • cellular localization • nitrogen compound transport • nucleocytoplasmic transport • nuclear transport • intracellular transport • protein localization to nucleus • import into nucleus • establishment of protein localization to organelle • protein transport • establishment of localization in cell • macromolecule localization • protein localization to organelle • protein import into nucleus • intracellular protein localization • intracellular protein transport • response to stress • multicellular organismal response to stress • trans-synaptic signaling • modulation of chemical synaptic transmission • cell-cell signaling • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • postsynaptic modulation of chemical synaptic transmission • mitotic cell cycle process • cell cycle phase transition • cell cycle • G1/S transition of mitotic cell cycle • cell cycle G1/S phase transition • mitotic cell cycle • mitotic cell cycle phase transition • cell cycle process • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • regulation of system process • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • regulation of response to stimulus • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • regulation of body fluid levels • digestive system process • saliva secretion • positive regulation of secretion • regulation of saliva secretion • positive regulation of digestive system process • regulation of biological quality • secretion by tissue • secretion • regulation of digestive system process • regulation of secretion • body fluid secretion • digestion • positive regulation of transport • positive regulation of saliva secretion • striated muscle adaptation • positive regulation of cardiac muscle hypertrophy in response to stress • positive regulation of response to stimulus • regulation of cardiac muscle hypertrophy in response to stress • cardiac muscle adaptation • regulation of response to stress • positive regulation of muscle adaptation • cardiac muscle hypertrophy in response to stress • positive regulation of cardiac muscle adaptation • regulation of cardiac muscle adaptation • muscle hypertrophy in response to stress • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • epithelium development • epidermal cell differentiation • cellular developmental process • epidermis development • tissue development • epithelial cell differentiation • skin development • cell differentiation • keratinocyte differentiation • myotube cell development • skeletal muscle fiber development • skeletal muscle tissue development • cell development • muscle cell differentiation • myotube differentiation • striated muscle tissue development • muscle structure development • skeletal muscle organ development • striated muscle cell development • muscle cell development • muscle tissue development • muscle organ development • striated muscle cell differentiation • transition between fast and slow fiber • regulation of skeletal muscle adaptation • skeletal muscle adaptation • positive regulation of tissue remodeling • positive regulation of connective tissue replacement • regulation of tissue remodeling • tissue remodeling • connective tissue replacement • regulation of connective tissue replacement • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • regulation of intracellular signal transduction • regulation of calcineurin-mediated signaling • positive regulation of calcineurin-NFAT signaling cascade • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • regulation of calcineurin-NFAT signaling cascade • positive regulation of calcineurin-mediated signaling • positive regulation of intracellular signal transduction • positive regulation of signaling • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • neurogenesis • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • dendrite development • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • dendrite morphogenesis • nervous system development • cell morphogenesis involved in neuron differentiation • generation of neurons • anatomical structure morphogenesis • neuron development • cell population proliferation • regulation of cell proliferation involved in kidney morphogenesis • kidney morphogenesis • regulation of cell population proliferation • animal organ morphogenesis • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of dendrite morphogenesis • negative regulation of cellular component organization • regulation of cell projection organization • regulation of dendrite development • negative regulation of multicellular organismal process • regulation of neuron projection development • regulation of cellular component organization • regulation of nervous system development • negative regulation of neurogenesis • negative regulation of nervous system development • negative regulation of cell differentiation • negative regulation of cell projection organization • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • negative regulation of dendrite morphogenesis • negative regulation of developmental process • negative regulation of cell development • regulation of plasma membrane bounded cell projection organization • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • cell surface receptor signaling pathway • nervous system process • excitatory postsynaptic potential • regulation of membrane potential • positive regulation of cell population proliferation • regulation of leukocyte activation • regulation of cell activation • positive regulation of cell activation • T cell activation • lymphocyte proliferation • positive regulation of leukocyte activation • regulation of immune system process • positive regulation of immune system process • regulation of leukocyte proliferation • positive regulation of T cell activation • positive regulation of lymphocyte proliferation • positive regulation of T cell proliferation • positive regulation of activated T cell proliferation • mononuclear cell proliferation • regulation of leukocyte cell-cell adhesion • positive regulation of leukocyte proliferation • regulation of activated T cell proliferation • positive regulation of leukocyte cell-cell adhesion • lymphocyte activation • leukocyte proliferation • leukocyte cell-cell adhesion • leukocyte activation • activated T cell proliferation • positive regulation of cell-cell adhesion • positive regulation of lymphocyte activation • cell adhesion • cell-cell adhesion • positive regulation of mononuclear cell proliferation • regulation of cell-cell adhesion • T cell proliferation • regulation of lymphocyte proliferation • positive regulation of cell adhesion • regulation of cell adhesion • cell activation • regulation of T cell activation • regulation of T cell proliferation • immune system process • regulation of mononuclear cell proliferation • regulation of lymphocyte activation • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • positive regulation of calcium ion import across plasma membrane • positive regulation of monoatomic ion transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of monoatomic ion transmembrane transport • regulation of osteoblast differentiation • osteoblast differentiation • positive regulation of osteoblast differentiation • ossification • positive regulation of cell differentiation • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • cellular response to nitrogen compound • response to angiotensin • response to peptide hormone • angiotensin-activated signaling pathway • cellular response to angiotensin • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • cellular response to endogenous stimulus • response to hormone • regulation of G protein-coupled receptor signaling pathway • cellular response to hormone stimulus • negative regulation of response to stimulus • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • negative regulation of signal transduction • regulation of angiotensin-activated signaling pathway • cellular response to chemical stimulus • negative regulation of angiotensin-activated signaling pathway • G protein-coupled receptor signaling pathway • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • positive regulation of cellular component organization • regulation of vesicle-mediated transport • vesicle-mediated transport • positive regulation of endocytosis • endocytosis • regulation of endocytosis • myeloid leukocyte differentiation • regulation of leukocyte differentiation • positive regulation of osteoclast differentiation • regulation of osteoclast differentiation • positive regulation of hemopoiesis • osteoclast differentiation • hemopoiesis • regulation of myeloid cell differentiation • positive regulation of cell development • regulation of myeloid leukocyte differentiation • positive regulation of myeloid leukocyte differentiation • myeloid cell differentiation • positive regulation of myeloid cell differentiation • regulation of hemopoiesis • positive regulation of leukocyte differentiation • leukocyte differentiation • phosphatase complex • catalytic complex • protein serine/threonine phosphatase complex • sarcolemma • synapse • cell junction • glutamatergic synapse • calcineurin complex • intracellular protein-containing complex • neuron spine • neuron projection • dendritic spine • plasma membrane bounded cell projection • somatodendritic compartment • cell projection • postsynapse • dendrite • dendritic tree • mitochondrion • Schaffer collateral - CA1 synapse • cytoplasmic side of plasma membrane • nucleus • amide binding • amyloid-beta binding • peptide binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • catecholamine binding • norepinephrine binding • calcium ion binding • protein domain specific binding • enzyme regulator activity • calcium-dependent protein serine/threonine phosphatase regulator activity • phosphatase regulator activity • protein phosphatase regulator activity • phosphatase binding • response to nutrient levels • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • energy homeostasis • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of biomineral tissue development • biomineral tissue development • bone mineralization • positive regulation of bone mineralization • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • growth • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • fat cell differentiation • brown fat cell differentiation • muscle contraction • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • receptor-mediated endocytosis • endosome to lysosome transport • lysosomal transport • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • autophagosome maturation • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to amyloid-beta • response to amyloid-beta • regulation of sodium ion transport • sodium ion transport • heat generation • positive regulation of excitatory postsynaptic potential • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • heart development • circulatory system development • peripheral nervous system axon ensheathment • peripheral nervous system development • glial cell development • myelination • Schwann cell development • gliogenesis • axon ensheathment • ensheathment of neurons • glial cell differentiation • myelination in peripheral nervous system • Schwann cell differentiation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • vasculature development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • mesenchyme development • mesenchymal cell differentiation • epithelial to mesenchymal transition • respiratory tube development • lung epithelium development • lung epithelial cell differentiation • lung cell differentiation • lung development • respiratory system development • regulation of synaptic vesicle cycle • synaptic vesicle cycle • vesicle-mediated transport in synapse • receptor internalization • postsynaptic neurotransmitter receptor internalization • regulation of receptor internalization • regulation of postsynaptic neurotransmitter receptor internalization • regulation of receptor-mediated endocytosis • neurotransmitter receptor internalization • regulation of postsynaptic membrane neurotransmitter receptor levels • postsynaptic endocytosis • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • neuronal dense core vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • cilium • ciliary basal body • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • apical part of cell • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • parallel fiber to Purkinje cell synapse • excitatory synapse • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse
SCOP2	Domain Identifier	• Rotamase-like • Metallo-dependent phosphatases • EF-hand • G protein-coupled receptor-like
SCOP2	Family Identifier	• Rotamase-like • Metallo-dependent phosphatases • EF-hand • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>9CHV_Chain_R W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K M W T F G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S F L P I Q M H W Y C D F F T N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q D N L I R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	doi.org/10.1126/science.aaw8981
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	GTPL11074	-	3.1	2020-03-25	doi.org/10.1038/s41589-020-0549-2
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	Cmpd-15	-	2.7	2017-08-16	doi.org/10.1038/nature23652
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs(CT)	3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	doi.org/10.1016/j.cell.2019.04.021
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	doi.org/10.1016/j.str.2008.05.001
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	doi.org/10.1021/ja105108q
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	3.16	2010-08-11	doi.org/10.1021/ja105108q
	2R4R	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	2R4S	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	doi.org/10.1038/nature06325
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	doi.org/10.1038/nature08650
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	doi.org/10.1038/nature09648
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.5	2011-01-12	doi.org/10.1038/nature09665
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	doi.org/10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	doi.org/10.1038/nature10361
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	doi.org/10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.1	2013-09-25	doi.org/10.1038/nature12572
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	L-Epinephrine	-	-	3.2	2013-09-25	doi.org/10.1038/nature12572
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-07-13	doi.org/10.1038/nature18636
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-08-17	doi.org/10.1038/nprot.2017.057
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	doi.org/10.1038/s41421-020-0176-9
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	doi.org/10.1038/s41586-024-07153-1
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	doi.org/10.1038/s41589-018-0145-x
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Formoterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	doi.org/10.1038/s41589-023-01389-0
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	doi.org/10.1038/s41594-019-0330-y
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	35V	-	-	3.3	2014-07-23	doi.org/10.1073/pnas.1410415111
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Noradrenaline	-	-	3.49	2024-11-13	doi.org/10.1073/pnas.2414544121
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.5	2024-11-13	doi.org/10.1073/pnas.2414544121
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	doi.org/10.1093/nsr/nwaa284
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.4	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carvedilol	-	-	2.5	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	S-Propranolol	-	-	2.9	2019-11-13	doi.org/10.1107/S2052252519013137
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	doi.org/10.1107/S2052252519013137
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.48	2016-01-13	doi.org/10.1107/S2059798315021683
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.8	2016-01-13	doi.org/10.1107/S2059798315021683
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	doi.org/10.1126/science.1150577
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.99	2012-10-24	doi.org/10.1371/journal.pone.0046039
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9CHV.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.