psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G37	R:R:M40	3.49	No	No	0	5	6
2	R:R:I43	R:R:M40	2.92	No	No	4	6	6
3	R:R:M40	R:R:W313	10.47	No	No	4	6	5
4	R:R:I43	R:R:W313	7.05	No	No	4	6	5
5	R:R:I47	R:R:V44	6.14	Yes	No	3	8	6
6	R:R:V44	R:R:V87	8.02	No	Yes	3	6	7
7	R:R:G83	R:R:I47	3.53	No	Yes	3	7	8
8	R:R:I47	R:R:V87	6.14	Yes	Yes	3	8	7
9	R:R:I47	R:R:S319	6.19	Yes	No	0	8	9
10	R:R:L84	R:R:V48	13.41	No	No	0	5	6
11	R:R:G50	R:R:P323	4.06	No	Yes	0	8	9
12	R:R:D79	R:R:N51	12.12	No	No	0	9	9
13	R:R:N51	R:R:P323	3.26	No	Yes	0	9	9
14	R:R:I55	R:R:V52	7.68	No	No	0	7	3
15	R:R:L80	R:R:V52	2.98	No	No	0	7	3
16	R:R:F336	R:R:L53	13.4	Yes	No	0	7	6
17	R:R:L339	R:R:L53	9.69	No	No	5	6	6
18	R:R:L340	R:R:L53	2.77	No	No	5	6	6
19	R:R:F332	R:R:V54	9.18	Yes	No	0	9	9
20	R:R:A57	R:R:F332	2.77	No	Yes	0	8	9
21	R:R:I58	R:R:T73	10.64	No	No	0	7	6
22	R:R:F61	R:R:L64	3.65	No	No	0	6	8
23	R:R:F332	R:R:L64	7.31	Yes	No	2	9	8
24	R:R:A335	R:R:L64	4.73	No	No	2	7	8
25	R:R:N69	R:R:T66	5.85	No	No	0	9	7
26	R:R:Q142	R:R:T66	2.83	No	No	0	4	7
27	R:R:F71	R:R:V67	3.93	Yes	No	1	8	6
28	R:R:D130	R:R:V67	5.84	Yes	No	1	8	6
29	R:R:L145	R:R:V67	2.98	Yes	No	1	7	6
30	R:R:R131	R:R:T68	10.35	Yes	No	0	9	8
31	R:R:L275	R:R:T68	4.42	No	No	0	8	8
32	R:R:I72	R:R:N69	4.25	No	No	0	8	9
33	R:R:R151	R:R:Y70	14.4	No	No	0	3	4
34	R:R:F71	R:R:V126	6.55	Yes	No	1	8	7
35	R:R:F71	R:R:I127	8.79	Yes	Yes	1	8	9
36	R:R:D130	R:R:F71	3.58	Yes	Yes	1	8	8
37	R:R:A150	R:R:F71	2.77	No	Yes	0	7	8
38	R:R:F71	R:R:I154	6.28	Yes	No	0	8	8
39	R:R:I278	R:R:I72	2.94	No	No	0	8	8
40	R:R:I72	R:R:Y326	10.88	No	Yes	0	8	9
41	R:R:L75	R:R:S74	3	No	No	1	9	9
42	R:R:S74	R:R:T123	3.2	No	Yes	1	9	8
43	R:R:I154	R:R:S74	3.1	No	No	0	8	9
44	R:R:L75	R:R:T123	4.42	No	Yes	1	9	8
45	R:R:L124	R:R:L75	2.77	No	No	1	8	9
46	R:R:D79	R:R:S319	7.36	No	No	0	9	9
47	R:R:L80	R:R:L84	2.77	No	No	0	7	5
48	R:R:I112	R:R:V81	3.07	Yes	No	0	4	7
49	R:R:M82	R:R:V86	7.61	No	No	0	7	7
50	R:R:C116	R:R:M82	8.1	No	No	0	7	7
51	R:R:G83	R:R:V87	3.68	No	Yes	3	7	7
52	R:R:I112	R:R:V86	4.61	Yes	No	0	4	7
53	R:R:P88	R:R:V87	3.53	No	Yes	0	8	7
54	R:R:F89	R:R:W109	31.07	No	No	0	5	5
55	R:R:F108	R:R:S111	3.96	No	No	0	5	6
56	R:R:I112	R:R:L115	4.28	Yes	Yes	0	4	5
57	R:R:C116	R:R:I112	3.27	No	Yes	0	7	4
58	R:R:T118	R:R:V114	6.35	Yes	No	0	6	5
59	R:R:L115	R:R:W158	19.36	Yes	No	0	5	9
60	R:R:L115	R:R:S161	4.5	Yes	Yes	0	5	8
61	R:R:V117	R:R:W286	13.48	No	Yes	0	6	8
62	R:R:S161	R:R:T118	4.8	Yes	Yes	6	8	6
63	R:R:T118	R:R:T164	4.71	Yes	No	6	6	5
64	R:R:S207	R:R:T118	7.99	No	Yes	0	5	6
65	R:R:A119	R:R:S161	3.42	No	Yes	0	7	8
66	R:R:F282	R:R:S120	6.61	Yes	No	0	9	9
67	R:R:I121	R:R:P211	6.77	No	No	0	7	8
68	R:R:I121	R:R:L212	2.85	No	No	0	7	7
69	R:R:F282	R:R:I121	5.02	Yes	No	0	9	7
70	R:R:E122	R:R:V157	2.85	No	No	0	5	7
71	R:R:I127	R:R:T123	3.04	Yes	Yes	1	9	8
72	R:R:L124	R:R:M215	5.65	No	No	1	8	8
73	R:R:L124	R:R:M279	4.24	No	No	1	8	8
74	R:R:C125	R:R:I214	3.27	No	No	0	7	6
75	R:R:C125	R:R:M215	4.86	No	No	0	7	8
76	R:R:I127	R:R:V126	3.07	Yes	No	1	9	7
77	R:R:I127	R:R:R131	3.76	Yes	Yes	1	9	9
78	R:R:V129	R:R:V218	6.41	No	No	0	6	6
79	R:R:D130	R:R:R131	8.34	Yes	Yes	1	8	9
80	R:R:D130	R:R:S143	11.78	Yes	No	1	8	4
81	R:R:D130	R:R:L145	4.07	Yes	Yes	1	8	7
82	R:R:A134	R:R:R131	4.15	No	Yes	0	8	9
83	R:R:R131	R:R:Y141	8.23	Yes	Yes	1	9	7
84	R:R:Q142	R:R:R131	5.84	No	Yes	0	4	9
85	R:R:L272	R:R:R131	3.64	No	Yes	1	7	9
86	R:R:F133	R:R:Y132	4.13	No	Yes	0	5	8
87	R:R:T136	R:R:Y132	13.73	No	Yes	0	7	8
88	R:R:R221	R:R:Y132	10.29	No	Yes	0	5	8
89	R:R:V222	R:R:Y132	5.05	No	Yes	0	8	8
90	R:R:I135	R:R:Y141	6.04	No	Yes	0	9	7
91	R:R:P138	R:R:S137	5.34	No	No	0	8	6
92	R:R:F139	R:R:K140	27.3	No	No	0	6	5
93	R:R:F264	R:R:Y141	4.13	Yes	Yes	1	4	7
94	R:R:L272	R:R:Y141	8.21	No	Yes	1	7	7
95	R:R:L145	R:R:S143	4.5	Yes	No	1	7	4
96	R:R:I153	R:R:L145	4.28	No	Yes	0	6	7
97	R:R:N148	R:R:T146	8.77	No	No	7	4	8
98	R:R:K149	R:R:T146	13.51	No	No	7	5	8
99	R:R:K147	R:R:N148	4.2	No	No	0	1	4
100	R:R:K149	R:R:N148	5.6	No	No	7	5	4
101	R:R:I159	R:R:L155	2.85	No	No	0	4	3
102	R:R:S161	R:R:T164	3.2	Yes	No	6	8	5
103	R:R:I205	R:R:Y209	7.25	No	No	0	4	5
104	R:R:F208	R:R:Y209	3.09	No	No	0	8	5
105	R:R:F208	R:R:F290	28.94	No	Yes	0	8	7
106	R:R:V213	R:R:Y209	12.62	No	No	0	4	5
107	R:R:P211	R:R:V210	3.53	No	No	0	8	5
108	R:R:L212	R:R:V216	2.98	No	No	0	7	5
109	R:R:M215	R:R:M279	4.33	No	No	1	8	8
110	R:R:F217	R:R:V216	5.24	No	No	0	4	5
111	R:R:V222	R:R:Y219	3.79	No	Yes	0	8	9
112	R:R:F223	R:R:Y219	6.19	No	Yes	0	6	9
113	R:R:G276	R:R:Y219	4.35	No	Yes	0	6	9
114	R:R:M279	R:R:Y219	9.58	No	Yes	0	8	9
115	R:R:Q224	R:R:S220	2.89	No	No	0	3	3
116	R:R:F223	R:R:Q224	3.51	No	No	0	6	3
117	R:R:A226	R:R:F264	2.77	No	Yes	0	8	4
118	R:R:K227	R:R:L230	4.23	No	No	1	6	5
119	R:R:H269	R:R:K227	10.48	Yes	No	1	5	6
120	R:R:F264	R:R:Q229	12.88	Yes	No	0	4	7
121	R:R:F264	R:R:L230	6.09	Yes	No	1	4	5
122	R:R:H269	R:R:L230	21.86	Yes	No	1	5	5
123	R:R:K235	R:R:Q231	14.92	No	No	0	5	5
124	R:R:D234	R:R:S236	8.83	Yes	No	0	4	4
125	R:R:D234	R:R:E237	3.9	Yes	No	0	4	3
126	R:R:E237	R:R:H241	11.08	No	No	0	3	3
127	R:R:F240	R:R:R239	8.55	No	No	0	4	4
128	R:R:F264	R:R:H269	7.92	Yes	Yes	1	4	5
129	R:R:H269	R:R:L266	3.86	Yes	No	0	5	5
130	R:R:E268	R:R:K267	6.75	No	No	0	7	6
131	R:R:K270	R:R:K273	5.75	No	No	0	7	7
132	R:R:K273	R:R:S329	3.06	No	No	0	7	8
133	R:R:T274	R:R:Y326	9.99	No	Yes	2	8	9
134	R:R:S329	R:R:T274	3.2	No	No	2	8	8
135	R:R:P330	R:R:T274	12.24	No	No	2	5	8
136	R:R:I278	R:R:L275	2.85	No	No	0	8	8
137	R:R:I277	R:R:I325	13.25	No	No	0	7	8
138	R:R:I278	R:R:N322	7.08	No	No	0	8	9
139	R:R:N318	R:R:T281	5.85	Yes	No	0	9	6
140	R:R:F321	R:R:T281	5.19	No	No	0	6	6
141	R:R:F282	R:R:W286	12.03	Yes	Yes	0	9	8
142	R:R:F282	R:R:N318	12.08	Yes	Yes	0	9	9
143	R:R:L284	R:R:T283	7.37	No	No	0	5	7
144	R:R:L287	R:R:T283	2.95	Yes	No	0	6	7
145	R:R:C285	R:R:N318	3.15	No	Yes	0	9	9
146	R:R:F290	R:R:W286	5.01	Yes	Yes	0	7	8
147	R:R:G315	R:R:W286	11.26	No	Yes	0	7	8
148	R:R:L287	R:R:P288	3.28	Yes	No	0	6	9
149	R:R:I291	R:R:L287	7.14	No	Yes	0	6	6
150	R:R:F289	R:R:F290	8.57	No	Yes	0	6	7
151	R:R:F289	R:R:N312	10.87	No	No	0	6	5
152	R:R:I314	R:R:L311	4.28	No	No	0	7	5
153	R:R:N312	R:R:Y316	6.98	No	No	0	5	6
154	R:R:V317	R:R:W313	3.68	No	No	0	5	5
155	R:R:N318	R:R:N322	12.26	Yes	No	0	9	9
156	R:R:G320	R:R:P323	4.06	No	Yes	0	7	9
157	R:R:N322	R:R:P323	3.26	No	Yes	0	9	9
158	R:R:P330	R:R:Y326	19.47	No	Yes	2	5	9
159	R:R:F332	R:R:Y326	13.41	Yes	Yes	2	9	9
160	R:R:C327	R:R:F336	5.59	No	Yes	0	7	7
161	R:R:R328	R:R:R333	3.2	No	No	0	7	9
162	R:R:P330	R:R:S329	5.34	No	No	2	5	8
163	R:R:A335	R:R:F332	4.16	No	Yes	2	7	9
164	R:R:F332	R:R:F336	9.65	Yes	Yes	0	9	7
165	R:R:Q337	R:R:R333	11.68	No	No	0	4	9
166	R:R:E338	R:R:I334	19.13	No	No	0	4	4
167	R:R:Q337	R:R:R343	12.85	No	No	0	4	6
168	R:R:E338	R:R:L342	5.3	No	No	0	4	8
169	R:R:L339	R:R:L340	5.54	No	No	5	6	6
170	R:R:L342	R:R:S346	10.51	No	No	0	8	2
171	R:R:R343	R:R:R344	8.53	No	No	0	6	4
172	R:R:K348	R:R:R344	7.43	No	No	0	3	4
173	R:R:F290	R:R:S204	2.64	Yes	No	0	7	5
174	R:R:F49	R:R:V48	2.62	No	No	0	4	6
175	R:R:F133	R:R:V129	2.62	No	No	0	5	6
176	R:R:E62	R:R:Q65	2.55	No	No	0	6	8
177	R:R:K235	R:R:R239	2.48	No	No	0	5	4
178	R:R:F208	R:R:L287	2.44	No	Yes	0	8	6
179	R:R:F321	R:R:L324	2.44	No	No	0	6	6
180	R:R:I325	R:R:Y326	2.42	No	Yes	0	8	9
181	R:R:M82	R:R:Y316	2.39	No	No	0	7	6
182	R:R:F336	R:R:Q337	2.34	Yes	No	0	7	4
183	R:R:E268	R:R:F264	2.33	No	Yes	0	7	4
184	R:R:F71	R:R:Y70	2.06	Yes	No	0	8	4
185	R:R:G280	R:R:T283	1.82	No	No	0	5	7
186	R:R:G315	R:R:I314	1.76	No	No	0	7	7
187	R:R:C77	R:R:V81	1.71	No	No	0	6	7
188	R:R:A78	R:R:S120	1.71	No	No	0	8	9
189	R:R:G162	R:R:L115	1.71	No	Yes	0	4	5
190	R:R:A85	R:R:V81	1.7	No	No	0	4	7
191	R:R:A128	R:R:V218	1.7	No	No	0	8	6
192	R:R:E237	R:R:G238	1.64	No	No	0	3	4
193	R:R:S203	R:R:S207	1.63	No	No	0	5	5
194	R:R:A46	R:R:I47	1.62	No	Yes	0	5	8
195	R:R:A76	R:R:I55	1.62	No	No	0	9	7
196	R:R:A59	R:R:I58	1.62	No	No	0	4	7
197	R:R:S203	R:R:V206	1.62	No	No	0	5	4
198	R:R:C265	R:R:K267	1.62	No	No	0	3	6
199	R:R:A271	R:R:K267	1.61	No	No	0	8	6
200	R:R:V44	R:R:V48	1.6	No	No	0	6	6
201	R:R:T123	R:R:V157	1.59	Yes	No	0	8	7
202	R:R:I38	R:R:S41	1.55	No	No	0	5	4
203	R:R:I38	R:R:V39	1.54	No	No	0	5	5
204	R:R:I159	R:R:V160	1.54	No	No	0	4	4
205	R:R:A335	R:R:D331	1.54	No	No	0	7	7
206	R:R:M156	R:R:V152	1.52	No	No	0	4	4
207	R:R:L144	R:R:S137	1.5	No	No	0	4	6
208	R:R:L339	R:R:T56	1.47	No	No	0	6	5
209	R:R:D113	R:R:V86	1.46	No	No	0	7	7
210	R:R:I159	R:R:M156	1.46	No	No	0	4	4
211	R:R:D234	R:R:I233	1.4	Yes	No	0	4	6
212	R:R:D234	R:R:K235	1.38	Yes	No	0	4	5
213	R:R:F139	R:R:S137	1.32	No	No	0	6	6
214	R:R:F321	R:R:V317	1.31	No	No	0	6	5
215	R:R:I58	R:R:Y70	1.21	No	No	0	7	4
216	R:R:E225	R:R:R221	1.16	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I47	4.724	5	3	8
2	R:R:F71	4.85143	7	1	8
3	R:R:V87	5.3425	4	3	7
4	R:R:I112	3.8075	4	0	4
5	R:R:L115	7.4625	4	0	5
6	R:R:T118	5.9625	4	6	6
7	R:R:T123	3.0625	4	1	8
8	R:R:I127	4.665	4	1	9
9	R:R:D130	6.722	5	1	8
10	R:R:R131	6.33	7	1	9
11	R:R:Y132	8.3	4	0	8
12	R:R:Y141	6.6525	4	1	7
13	R:R:L145	3.9575	4	1	7
14	R:R:S161	3.98	4	6	8
15	R:R:Y219	5.9775	4	0	9
16	R:R:D234	3.8775	4	0	4
17	R:R:F264	6.02	6	1	4
18	R:R:H269	11.03	4	1	5
19	R:R:F282	8.935	4	0	9
20	R:R:W286	10.445	4	0	8
21	R:R:L287	3.9525	4	0	6
22	R:R:F290	11.29	4	0	7
23	R:R:N318	8.335	4	0	9
24	R:R:P323	3.66	4	0	9
25	R:R:Y326	11.234	5	2	9
26	R:R:F332	7.74667	6	2	9
27	R:R:F336	7.745	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F321	R:R:T281	13.8219	5.19	No	No	0	6	6
2	R:R:N318	R:R:T281	15.7255	5.85	Yes	No	0	9	6
3	R:R:N318	R:R:N322	93.8663	12.26	Yes	No	0	9	9
4	R:R:N322	R:R:P323	35.3532	3.26	No	Yes	0	9	9
5	R:R:N51	R:R:P323	30.2771	3.26	No	Yes	0	9	9
6	R:R:D79	R:R:N51	28.5427	12.12	No	No	0	9	9
7	R:R:D79	R:R:S319	26.7872	7.36	No	No	0	9	9
8	R:R:I47	R:R:S319	25.0106	6.19	Yes	No	0	8	9
9	R:R:I47	R:R:V44	15.6409	6.14	Yes	No	3	8	6
10	R:R:V44	R:R:V48	13.9805	1.6	No	No	0	6	6
11	R:R:L84	R:R:V48	10.0888	13.41	No	No	0	5	6
12	R:R:F332	R:R:F336	31.0808	9.65	Yes	Yes	0	9	7
13	R:R:F332	R:R:Y326	47.8849	13.41	Yes	Yes	2	9	9
14	R:R:I72	R:R:Y326	72.1975	10.88	No	Yes	0	8	9
15	R:R:I278	R:R:I72	55.2982	2.94	No	No	0	8	8
16	R:R:I278	R:R:N322	100	7.08	No	No	0	8	9
17	R:R:F336	R:R:L53	10.607	13.4	Yes	No	0	7	6
18	R:R:I278	R:R:L275	88.0499	2.85	No	No	0	8	8
19	R:R:L275	R:R:T68	87.4154	4.42	No	No	0	8	8
20	R:R:R131	R:R:T68	86.7809	10.35	Yes	No	0	9	8
21	R:R:I127	R:R:R131	64.8266	3.76	Yes	Yes	1	9	9
22	R:R:F71	R:R:I127	18.5491	8.79	Yes	Yes	1	8	9
23	R:R:F71	R:R:Y70	21.7745	2.06	Yes	No	0	8	4
24	R:R:I58	R:R:Y70	13.1239	1.21	No	No	0	7	4
25	R:R:D130	R:R:R131	25.4124	8.34	Yes	Yes	1	8	9
26	R:R:D130	R:R:F71	17.2695	3.58	Yes	Yes	1	8	8
27	R:R:I72	R:R:N69	24.9365	4.25	No	No	0	8	9
28	R:R:N69	R:R:T66	24.302	5.85	No	No	0	9	7
29	R:R:Q142	R:R:T66	23.6675	2.83	No	No	0	4	7
30	R:R:Q142	R:R:R131	24.0165	5.84	No	Yes	0	4	9
31	R:R:I127	R:R:T123	49.9365	3.04	Yes	Yes	1	9	8
32	R:R:L75	R:R:T123	42.4281	4.42	No	Yes	1	9	8
33	R:R:L124	R:R:L75	43.7712	2.77	No	No	1	8	9
34	R:R:F282	R:R:N318	87.6058	12.08	Yes	Yes	0	9	9
35	R:R:F282	R:R:W286	80.3405	12.03	Yes	Yes	0	9	8
36	R:R:F290	R:R:W286	75.5288	5.01	Yes	Yes	0	7	8
37	R:R:F289	R:R:F290	61.6963	8.57	No	Yes	0	6	7
38	R:R:F289	R:R:N312	60.4061	10.87	No	No	0	6	5
39	R:R:N312	R:R:Y316	59.0948	6.98	No	No	0	5	6
40	R:R:M82	R:R:Y316	57.7623	2.39	No	No	0	7	6
41	R:R:M82	R:R:V86	29.1349	7.61	No	No	0	7	7
42	R:R:I112	R:R:V86	26.0258	4.61	Yes	No	0	4	7
43	R:R:C116	R:R:M82	27.4217	8.1	No	No	0	7	7
44	R:R:C116	R:R:I112	25.8672	3.27	No	Yes	0	7	4
45	R:R:I112	R:R:V81	10.7445	3.07	Yes	No	0	4	7
46	R:R:I112	R:R:L115	38.4941	4.28	Yes	Yes	0	4	5
47	R:R:L115	R:R:S161	28.2466	4.5	Yes	Yes	0	5	8
48	R:R:S161	R:R:T118	17.7559	4.8	Yes	Yes	6	8	6
49	R:R:S207	R:R:T118	10.7445	7.99	No	Yes	0	5	6
50	R:R:F282	R:R:I121	11.8761	5.02	Yes	No	0	9	7
51	R:R:L124	R:R:M279	34.7293	4.24	No	No	1	8	8
52	R:R:M279	R:R:Y219	33.0055	9.58	No	Yes	0	8	9
53	R:R:V222	R:R:Y219	21.6899	3.79	No	Yes	0	8	9
54	R:R:V222	R:R:Y132	19.3634	5.05	No	Yes	0	8	8
55	R:R:R131	R:R:Y141	31.0808	8.23	Yes	Yes	1	9	7
56	R:R:F264	R:R:Y141	27.0199	4.13	Yes	Yes	1	4	7
57	R:R:F208	R:R:F290	19.5537	28.94	No	Yes	0	8	7
58	R:R:T274	R:R:Y326	10.5647	9.99	No	Yes	2	8	9
59	R:R:K273	R:R:S329	10.6282	3.06	No	No	0	7	8
60	R:R:P330	R:R:Y326	10.5647	19.47	No	Yes	2	5	9
61	R:R:F208	R:R:L287	11.9818	2.44	No	Yes	0	8	6
62	R:R:F336	R:R:Q337	15.9793	2.34	Yes	No	0	7	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 2R4R

PDB Summary
PDB	2R4R
Class	A
SubFamily	Amine
Type	Adrenergic
SubType	Beta2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.4
Date	2007-11-06
D.O.I.	10.1038/nature06325

Net Summary
I_min	2.77
Number of Linked Nodes	204
Number of Links	216
Number of Hubs	27
Number of Links mediated by Hubs	103
Number of Communities	7
Number of Nodes involved in Communities	43
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	20326
Length Of Smallest Path	3
Average Path Length	13.4381
Length of Longest Path	33
Minimum Path Strength	1.39
Average Path Strength	6.71412
Maximum Path Strength	18.755
Minimum Path Correlation	0.7
Average Path Correlation	0.941992
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	58.0317
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.9865
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• amide binding • amyloid-beta binding • binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • monoatomic cation transmembrane transporter activity • channel regulator activity • ion channel regulator activity • monoatomic ion channel activity • potassium ion transmembrane transporter activity • potassium channel activity • potassium channel regulator activity • monoatomic cation channel activity • passive transmembrane transporter activity • inorganic molecular entity transmembrane transporter activity • channel activity • molecular function regulator activity • inorganic cation transmembrane transporter activity • monoatomic ion transmembrane transporter activity • transporter activity • transporter regulator activity • metal ion transmembrane transporter activity • transmembrane transporter activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold
Gene Ontology	Biological Process	• multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • regulation of biological process • bone mineralization • animal organ development • biological regulation • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • positive regulation of phosphorylation • regulation of catalytic activity • regulation of transferase activity • positive regulation of phosphate metabolic process • cell surface receptor protein tyrosine kinase signaling pathway • cellular component biogenesis • cellular component assembly • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • activation of transmembrane receptor protein tyrosine kinase activity • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of molecular function • positive regulation of kinase activity • regulation of kinase activity • activation of protein kinase activity • macromolecule modification • regulation of phosphorus metabolic process • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • cellular component organization • positive regulation of molecular function • positive regulation of protein modification process • protein-containing complex assembly • cellular component organization or biogenesis • protein metabolic process • positive regulation of protein kinase activity • enzyme-linked receptor protein signaling pathway • positive regulation of transferase activity • cell surface receptor signaling pathway • protein-containing complex organization • positive regulation of catalytic activity • regulation of protein kinase activity • regulation of phosphorylation • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • autophagosome maturation • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • protein-containing complex • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • cell periphery • apical part of cell • plasma membrane • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07550
Sequence	>2R4R_Chain_R G I V M S L I V L A I V F G N V L V I T A I A F E R L Q T V T N Y F I T S L A C A D L V M G L A V V P F G F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S P F K Y Q S L L T K N K A R V I I L M V W I V S G L T S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E G R F H V F C L K E H K A L K T L G I I M G T F T L C W L P F F I L N W I G Y V N S G F N P L I Y C R S P D F R I A F Q E L L C L R R S S L K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9CHV	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.95	2024-11-13	10.1073/pnas.2414544121
	9CHU	A	Amine	Adrenergic	β₂	Homo sapiens	Noradrenaline	-	-	3.49	2024-11-13	10.1073/pnas.2414544121
	9CHX	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.5	2024-11-13	10.1073/pnas.2414544121
	8W1V	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-	-	3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	8W1V (Multimeric)	A	Amine	Adrenergic	β₂	Homo sapiens	PubChem 171716265	-		3	2024-07-17	doi.org/10.1021/acs.jmedchem.4c00578
	8GH1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4.1	2024-03-06	10.1038/s41586-024-07153-1
	8GH0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	4	2024-03-06	10.1038/s41586-024-07153-1
	8GGZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	10.1038/s41586-024-07153-1
	8GGY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.9	2024-03-06	10.1038/s41586-024-07153-1
	8GGX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GGK	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GEJ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.2	2024-03-06	10.1038/s41586-024-07153-1
	8GEJ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.2	2024-03-06	10.1038/s41586-024-07153-1
	8GEI	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4.1	2024-03-06	10.1038/s41586-024-07153-1
	8GEI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4.1	2024-03-06	10.1038/s41586-024-07153-1
	8GEH	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	4	2024-03-06	10.1038/s41586-024-07153-1
	8GEH (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		4	2024-03-06	10.1038/s41586-024-07153-1
	8GEG	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEG (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8GEE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.7	2024-03-06	10.1038/s41586-024-07153-1
	8GEE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.7	2024-03-06	10.1038/s41586-024-07153-1
	8GED	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GED (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GEB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GEA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GEA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GE9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GE9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GE8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GE1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GE1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GDZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GDZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-		3.5	2024-03-06	10.1038/s41586-024-07153-1
	7XKA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	-	-	3.1	2023-04-26	10.1038/s41467-023-37808-y
	7XK9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Isoproterenol	Na	-	3.4	2023-04-26	doi.org/10.1038/s41467-023-37808-y
	8JJO	A	Amine	Adrenergic	β₂	Homo sapiens	Alprenolol	-	-	3.4	2023-09-06	10.1038/s41589-023-01389-0
	8JJL	A	Amine	Adrenergic	β₂	Homo sapiens	Olodaterol	-	-	3.2	2023-09-06	10.1038/s41589-023-01389-0
	8JJ8	A	Amine	Adrenergic	β₂	Homo sapiens	Formoterol	-	-	3.2	2023-09-06	10.1038/s41589-023-01389-0
	7DHR	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-	Gs/β1/γ2	3.8	2020-12-16	10.1093/nsr/nwaa284
	7DHR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Isoprenaline	-		3.8	2020-12-16	10.1093/nsr/nwaa284
	7DHI	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-	Gs/β1/γ2	3.26	2020-12-16	10.1093/nsr/nwaa284
	7DHI (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Salbutamol	-		3.26	2020-12-16	10.1093/nsr/nwaa284
	7BZ2	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-	Gs/β1/γ2	3.82	2020-08-05	10.1038/s41421-020-0176-9
	7BZ2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Arformoterol	-		3.82	2020-08-05	10.1038/s41421-020-0176-9
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	GTPL11074	-	3.1	2020-03-25	10.1038/s41589-020-0549-2
	6NI3	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.8	2019-11-20	10.1038/s41594-019-0330-y
	6NI3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.8	2019-11-20	10.1038/s41594-019-0330-y
	6PS6	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.7	2019-11-13	10.1107/S2052252519013137
	6PS5	A	Amine	Adrenergic	β₂	Homo sapiens	S-Propranolol	-	-	2.9	2019-11-13	10.1107/S2052252519013137
	6PS4	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.6	2019-11-13	10.1107/S2052252519013137
	6PS3	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carvedilol	-	-	2.5	2019-11-13	10.1107/S2052252519013137
	6PS2	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.4	2019-11-13	10.1107/S2052252519013137
	6PS1	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	3.2	2019-11-13	10.1107/S2052252519013137
	6PS0	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.4	2019-11-13	10.1107/S2052252519013137
	6PRZ	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	2.8	2019-11-13	10.1107/S2052252519013137
	6N48	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	PubChem 138454256	-	3.2	2019-06-26	10.1126/science.aaw8981
	6E67	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs (fused)	3.7	2019-06-05	10.1016/j.cell.2019.04.021
	6E67 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.7	2019-06-05	10.1016/j.cell.2019.04.021
	6MXT	A	Amine	Adrenergic	β₂	Homo sapiens	Salmeterol	-	-	2.96	2018-11-14	10.1038/s41589-018-0145-x
	5X7D	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	PubChem 129318963	-	2.7	2017-08-16	10.1038/nature23652
	5D6L	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-08-17	10.1038/nprot.2017.057
	5JQH	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.2	2016-07-13	10.1038/nature18636
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.8	2016-01-13	10.1107/S2059798315021683
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.48	2016-01-13	10.1107/S2059798315021683
	4QKX	A	Amine	Adrenergic	β₂	Homo sapiens	35V	-	-	3.3	2014-07-23	10.1073/pnas.1410415111
	4LDO	A	Amine	Adrenergic	β₂	Homo sapiens	L-Epinephrine	-	-	3.2	2013-09-25	10.1038/nature12572
	4LDL	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.1	2013-09-25	10.1038/nature12572
	4LDE	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	2.79	2013-09-25	10.1038/nature12572
	4GBR	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.99	2012-10-24	10.1371/journal.pone.0046039
	3SN6	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	Gs/β1/γ2	3.2	2011-07-20	10.1038/nature10361
	3SN6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-		3.2	2011-07-20	10.1038/nature10361
	3P0G	A	Amine	Adrenergic	β₂	Homo sapiens	BI167107	-	-	3.5	2011-01-19	10.1038/nature09648
	3PDS	A	Amine	Adrenergic	β₂	Homo sapiens	Hydroxybenzylisoproterenol	-	-	3.5	2011-01-12	10.1038/nature09665
	3NYA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	-	-	3.16	2010-08-11	10.1021/ja105108q
	3NY9	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	10.1021/ja105108q
	3NY8	A	Amine	Adrenergic	β₂	Homo sapiens	ICI118-551	-	-	2.84	2010-08-11	10.1021/ja105108q
	3KJ6	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2010-02-16	10.1038/nature08650
	3D4S	A	Amine	Adrenergic	β₂	Homo sapiens	Timolol	-	-	2.8	2008-06-17	10.1016/j.str.2008.05.001
	2R4S	A	Amine	Adrenergic	β₂	Homo sapiens	-	-	-	3.4	2007-11-06	10.1038/nature06325
	2RH1	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.4	2007-10-30	10.1126/science.1150577

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