Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.3691010
2R:R:M40 3.75406
3R:R:N51 8.095439
4R:R:F61 5.075406
5R:R:R63 3.785406
6R:R:F71 5.582548
7R:R:V86 4.88507
8R:R:V87 3.6175427
9R:R:W99 9.452557
10R:R:W109 6.0775455
11R:R:V114 4.6875405
12R:R:I121 5.2417
13R:R:Y141 6.1407
14R:R:W158 4.9925409
15R:R:S165 4.194567
16R:R:F166 8.1775464
17R:R:Y174 6.775405
18R:R:F193 7.48414
19R:R:Y199 7.186506
20R:R:F208 9.976518
21R:R:Y219 4.605419
22R:R:R221 8.9175475
23R:R:F282 5.8625419
24R:R:W286 8.75518
25R:R:F289 9.298516
26R:R:F290 8.74833617
27R:R:V297 3.8825405
28R:R:Y308 6.898515
29R:R:L311 2.45405
30R:R:W313 5.845405
31R:R:Y316 12.405416
32R:R:F332 4.76333609
33R:R:F336 3.8275407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y316 27.13866.81YesYes106
2R:R:W313 R:R:Y316 29.667511.58YesYes056
3R:R:M40 R:R:W313 17.75024.65YesYes065
4R:R:L95 R:R:M40 12.54284.24NoYes066
5L:L:?1 R:R:D113 53.705119.71YesNo107
6R:R:D113 R:R:V86 56.041511.69NoYes077
7R:R:M82 R:R:V86 37.95443.04NoYes077
8R:R:M82 R:R:S319 30.70474.6NoNo079
9R:R:D79 R:R:S319 27.015611.78NoNo099
10R:R:D79 R:R:N51 23.219616.16NoYes399
11R:R:L80 R:R:N51 11.83176.87NoYes079
12L:L:?1 R:R:V117 70.39678.66YesNo106
13R:R:V117 R:R:W286 39.05059.81NoYes168
14R:R:N318 R:R:W286 1007.91NoYes098
15R:R:N318 R:R:N322 95.78710.9NoNo099
16R:R:L124 R:R:N322 93.66455.49NoNo089
17R:R:L124 R:R:Y326 91.52594.69NoNo089
18R:R:I127 R:R:Y326 80.69936.04NoNo099
19R:R:I127 R:R:I72 76.29924.42NoNo098
20R:R:I72 R:R:T68 74.08043.04NoNo088
21R:R:T66 R:R:T68 71.85093.14NoNo078
22R:R:N69 R:R:T66 69.61088.77NoNo097
23R:R:F332 R:R:N69 67.35467.25YesNo099
24R:R:A57 R:R:F332 22.5622.77NoYes089
25R:R:A57 R:R:F336 20.09734.16NoYes087
26L:L:?1 R:R:F290 74.17669.44YesYes107
27R:R:F290 R:R:W286 56.70987.02YesYes178
28R:R:F332 R:R:L64 32.31392.44YesNo098
29R:R:A335 R:R:L64 29.8923.15NoNo078
30R:R:A335 R:R:F61 27.45942.77NoYes076
31R:R:F61 R:R:R63 12.59625.34YesYes066
32R:R:E338 R:R:F61 10.08883.5NoYes046
33L:L:?1 R:R:V114 88.05078.66YesYes005
34R:R:S165 R:R:V114 54.85993.23YesYes075
35R:R:L115 R:R:S165 52.38996.01NoYes057
36R:R:L115 R:R:W158 50.75923.42NoYes059
37R:R:S74 R:R:W158 59.09976.18NoYes099
38R:R:I154 R:R:S74 52.63589.29NoNo089
39R:R:F71 R:R:I154 50.45986.28YesNo088
40R:R:D130 R:R:F71 25.81275.97NoYes088
41R:R:F71 R:R:I153 18.94255.02YesNo486
42R:R:I112 R:R:V86 11.57513.07NoYes047
43R:R:V86 R:R:W109 19.30074.9YesYes075
44R:R:W109 R:R:W99 13.638812.18YesYes557
45R:R:F108 R:R:I112 10.50586.28NoNo054
46R:R:F166 R:R:S165 12.60166.61YesYes647
47R:R:F108 R:R:F166 10.69823.22NoYes054
48R:R:I169 R:R:V114 20.04383.07NoYes055
49R:R:I169 R:R:Y174 20.28448.46NoYes055
50R:R:V114 R:R:Y199 28.40573.79YesYes056
51R:R:Y174 R:R:Y199 34.31894.96YesYes056
52L:L:?1 R:R:S203 24.21944.36YesNo005
53R:R:S203 R:R:Y199 23.059213.99NoYes056
54R:R:I121 R:R:V117 30.90783.07YesNo176
55R:R:F290 R:R:S207 17.80375.28YesNo075
56R:R:S207 R:R:T118 16.66496.4NoNo056
57R:R:S161 R:R:T118 15.82556.4NoNo086
58R:R:A119 R:R:W158 14.32317.78NoYes079
59R:R:A119 R:R:S161 15.18393.42NoNo078
60R:R:I121 R:R:P211 11.41473.39YesNo078
61R:R:F282 R:R:I121 31.7743.77YesYes197
62R:R:F208 R:R:F290 46.72819.29YesYes187
63R:R:F208 R:R:F282 34.23878.57YesYes189
64R:R:I153 R:R:M156 16.64882.92NoNo064
65R:R:M156 R:R:V157 14.30183.04NoNo047
66R:R:E122 R:R:V157 11.94414.26NoNo057
67R:R:F282 R:R:M215 62.20597.46YesNo198
68R:R:A128 R:R:M215 28.92963.22NoNo188
69R:R:M215 R:R:Y219 30.99873.59NoYes189
70R:R:D130 R:R:L145 14.30185.43NoNo087
71R:R:A128 R:R:V218 27.34171.7NoNo086
72R:R:V218 R:R:Y132 22.46587.57NoNo068
73R:R:R221 R:R:Y132 17.50968.23YesNo758
74R:R:E225 R:R:R221 10.056713.96NoYes055
75R:R:L144 R:R:L145 11.9441.38NoNo047
76R:R:P168 R:R:Y199 14.83116.95NoYes056
77R:R:L167 R:R:P168 11.88524.93NoNo055
78R:R:Y174 R:R:Y185 40.90036.95YesNo051
79R:R:C184 R:R:Y185 31.99328.06NoNo011
80R:R:C184 R:R:F194 27.4548.38NoNo011
81R:R:A181 R:R:F194 18.34374.16NoNo041
82L:L:?1 R:R:Y308 14.36066.81YesYes105
83R:R:L275 R:R:Y219 17.37065.86NoYes089
84R:R:I278 R:R:Y219 12.40913.63NoYes089
85R:R:F223 R:R:L275 14.89523.65NoNo068
86R:R:I325 R:R:Y326 10.13156.04NoNo089
87R:R:H296 R:R:Y308 16.76118.71NoYes135
88R:R:H296 R:R:I303 17.28516.63NoNo033
89R:R:I303 R:R:V295 11.56444.61NoNo034
90R:R:A176 R:R:A181 13.77251.79NoNo014
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D113 19.71 1 Yes No 0 7 0 1
L:L:?1 R:R:V114 8.66 1 Yes Yes 0 5 0 1
L:L:?1 R:R:V117 8.66 1 Yes No 0 6 0 1
L:L:?1 R:R:F193 11.79 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S203 4.36 1 Yes No 0 5 0 1
L:L:?1 R:R:F289 14.15 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 9.44 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Y308 6.81 1 Yes Yes 0 5 0 1
L:L:?1 R:R:N312 13.3 1 Yes No 0 5 0 1
L:L:?1 R:R:Y316 6.81 1 Yes Yes 0 6 0 1
R:R:D113 R:R:V86 11.69 1 No Yes 7 7 1 2
R:R:D113 R:R:Y316 13.79 1 No Yes 7 6 1 1
R:R:S165 R:R:V114 3.23 6 Yes Yes 7 5 2 1
R:R:I169 R:R:V114 3.07 0 No Yes 5 5 2 1
R:R:V114 R:R:Y199 3.79 0 Yes Yes 5 6 1 2
R:R:I121 R:R:V117 3.07 1 Yes No 7 6 2 1
R:R:V117 R:R:W286 9.81 1 No Yes 6 8 1 2
R:R:I121 R:R:W286 10.57 1 Yes Yes 7 8 2 2
R:R:F193 R:R:T195 10.38 1 Yes No 4 3 1 2
R:R:F193 R:R:Y308 5.16 1 Yes Yes 4 5 1 1
R:R:T195 R:R:Y199 6.24 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 13.99 0 No Yes 5 6 1 2
R:R:F290 R:R:S204 3.96 1 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 1 No No 5 5 2 2
R:R:F290 R:R:S207 5.28 1 Yes No 7 5 1 2
R:R:F208 R:R:F290 19.29 1 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 7.02 1 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 7.5 1 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 10.32 1 Yes Yes 6 5 1 1
R:R:F289 R:R:L311 3.65 1 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 10.87 1 Yes No 6 5 1 1
R:R:H296 R:R:N293 6.38 1 No No 3 5 2 2
R:R:N293 R:R:Y308 3.49 1 No Yes 5 5 2 1
R:R:H296 R:R:Y308 8.71 1 No Yes 3 5 2 1
R:R:N312 R:R:Y316 17.44 1 No Yes 5 6 1 1
R:R:W313 R:R:Y316 11.58 0 Yes Yes 5 6 2 1
R:R:F193 R:R:T110 2.59 1 Yes No 4 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8GEB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.07
Number of Linked Nodes 257
Number of Links 281
Number of Hubs 33
Number of Links mediated by Hubs 126
Number of Communities 7
Number of Nodes involved in Communities 37
Number of Links involved in Communities 48
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 51085
Length Of Smallest Path 3
Average Path Length 14.2952
Length of Longest Path 33
Minimum Path Strength 1.22
Average Path Strength 6.72199
Maximum Path Strength 16.93
Minimum Path Correlation 0.7
Average Path Correlation 0.932355
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5.26316
Average % Of Corr. Nodes 52.5885
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.704
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • system process   • regulation of biological process   • nervous system process   • neuromuscular process   • regulation of system process   • biological regulation   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • positive regulation of biological process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • signal release   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • insulin secretion   • positive regulation of signaling   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • serotonin receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • adenylate cyclase-activating dopamine receptor signaling pathway   • G protein-coupled dopamine receptor signaling pathway   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • amyloid-beta binding   • peptide binding   • adenylate cyclase binding   • G protein-coupled amine receptor activity   • molecular transducer activity   • beta2-adrenergic receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • beta-adrenergic receptor activity   • adrenergic receptor activity   • potassium channel regulator activity   • channel regulator activity   • ion channel regulator activity   • molecular function regulator activity   • transporter regulator activity   • identical protein binding   • protein homodimerization activity   • protein dimerization activity   • cation binding   • ion binding   • catecholamine binding   • norepinephrine binding   • small molecule binding   • response to nutrient levels   • multicellular organismal-level homeostasis   • homeostatic process   • response to dietary excess   • diet induced thermogenesis   • temperature homeostasis   • energy homeostasis   • adaptive thermogenesis   • response to stress   • response to abiotic stimulus   • response to cold   • response to temperature stimulus   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-inhibiting adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • regulation of developmental process   • positive regulation of biological process   • regulation of biomineral tissue development   • regulation of bone mineralization   • positive regulation of ossification   • positive regulation of developmental process   • positive regulation of biomineral tissue development   • ossification   • biomineral tissue development   • regulation of multicellular organismal process   • regulation of multicellular organismal development   • bone mineralization   • tissue development   • positive regulation of bone mineralization   • positive regulation of multicellular organismal process   • regulation of ossification   • regulation of multicellular organism growth   • regulation of growth   • regulation of developmental growth   • negative regulation of multicellular organism growth   • developmental growth   • negative regulation of developmental process   • growth   • negative regulation of biological process   • multicellular organism growth   • negative regulation of developmental growth   • negative regulation of growth   • negative regulation of multicellular organismal process   • adenylate cyclase-activating adrenergic receptor signaling pathway   • fat cell differentiation   • cellular developmental process   • brown fat cell differentiation   • cell differentiation   • negative regulation of cardiac muscle cell apoptotic process   • muscle cell apoptotic process   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of cardiac muscle cell apoptotic process   • regulation of muscle cell apoptotic process   • regulation of programmed cell death   • cell death   • cardiac muscle cell apoptotic process   • negative regulation of apoptotic process   • regulation of striated muscle cell apoptotic process   • striated muscle cell apoptotic process   • negative regulation of muscle cell apoptotic process   • negative regulation of cellular process   • negative regulation of striated muscle cell apoptotic process   • apoptotic process   • programmed cell death   • regulation of system process   • muscle contraction   • muscle system process   • regulation of muscle system process   • negative regulation of muscle contraction   • smooth muscle contraction   • regulation of smooth muscle contraction   • regulation of muscle contraction   • negative regulation of smooth muscle contraction   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • positive regulation of metabolic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • positive regulation of cellular process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • regulation of transcription by RNA polymerase II   • primary metabolic process   • regulation of macromolecule metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • regulation of gene expression   • biosynthetic process   • positive regulation of RNA biosynthetic process   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of DNA-templated transcription   • regulation of metabolic process   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • localization   • import into cell   • transport   • receptor-mediated endocytosis   • endocytosis   • establishment of localization   • vesicle-mediated transport   • cellular localization   • endosome to lysosome transport   • intracellular transport   • lysosomal transport   • establishment of localization in cell   • vacuolar transport   • heart process   • regulation of actin filament-based process   • regulation of heart contraction   • cardiac muscle contraction   • striated muscle contraction   • circulatory system process   • actin filament-based process   • positive regulation of actin filament-based movement   • blood circulation   • cardiac muscle cell contraction   • regulation of cardiac muscle contraction   • positive regulation of cardiac muscle cell contraction   • actin filament-based movement   • regulation of blood circulation   • regulation of striated muscle contraction   • regulation of actin filament-based movement   • regulation of cardiac muscle cell contraction   • actin-mediated cell contraction   • heart contraction   • positive regulation of organelle organization   • catabolic process   • regulation of cellular component organization   • positive regulation of cellular component organization   • regulation of autophagosome maturation   • macroautophagy   • autophagy   • protein-containing complex disassembly   • regulation of autophagy   • regulation of protein-containing complex disassembly   • cellular component organization   • autophagosome maturation   • cellular component organization or biogenesis   • positive regulation of macroautophagy   • process utilizing autophagic mechanism   • positive regulation of protein-containing complex disassembly   • cellular component disassembly   • positive regulation of autophagy   • protein-containing complex organization   • regulation of catabolic process   • positive regulation of autophagosome maturation   • regulation of organelle organization   • positive regulation of catabolic process   • organelle organization   • regulation of macroautophagy   • positive regulation of cardiac muscle cell apoptotic process   • positive regulation of programmed cell death   • positive regulation of striated muscle cell apoptotic process   • positive regulation of apoptotic process   • positive regulation of muscle cell apoptotic process   • lipophagy   • positive regulation of lipophagy   • regulation of lipophagy   • response to psychosocial stress   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • positive regulation of cold-induced thermogenesis   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • positive regulation of signaling   • cell surface receptor signaling pathway   • ligand-gated ion channel signaling pathway   • ionotropic glutamate receptor signaling pathway   • glutamate receptor signaling pathway   • AMPA selective glutamate receptor signaling pathway   • regulation of tube diameter   • regulation of systemic arterial blood pressure mediated by a chemical signal   • regulation of blood pressure   • regulation of tube size   • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure   • negative regulation of blood pressure   • regulation of systemic arterial blood pressure by norepinephrine-epinephrine   • regulation of systemic arterial blood pressure   • negative regulation of systemic arterial blood pressure   • vascular process in circulatory system   • regulation of biological quality   • blood vessel diameter maintenance   • vasodilation   • regulation of anatomical structure size   • negative regulation of signaling   • negative regulation of response to stimulus   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • cellular response to amyloid-beta   • response to amyloid-beta   • regulation of localization   • regulation of transport   • regulation of monoatomic ion transport   • regulation of sodium ion transport   • metal ion transport   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • sodium ion transport   • heat generation   • regulation of postsynaptic membrane potential   • modulation of chemical synaptic transmission   • positive regulation of excitatory postsynaptic potential   • chemical synaptic transmission, postsynaptic   • modulation of excitatory postsynaptic potential   • mini excitatory postsynaptic potential   • trans-synaptic signaling   • chemical synaptic transmission   • regulation of nervous system process   • regulation of mini excitatory postsynaptic potential   • positive regulation of mini excitatory postsynaptic potential   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • excitatory postsynaptic potential   • regulation of membrane potential   • dense core granule   • intracellular vesicle   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • neuronal dense core vesicle   • vesicle membrane   • clathrin-coated vesicle   • endocytic vesicle membrane   • coated vesicle   • endocytic vesicle   • clathrin-coated vesicle membrane   • clathrin-coated endocytic vesicle membrane   • clathrin-coated endocytic vesicle   • cytoplasmic vesicle membrane   • coated vesicle membrane   • receptor complex   • intercellular bridge   • endosome membrane   • endosome   • intracellular membraneless organelle   • ciliary basal body   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • microtubule cytoskeleton   • apical part of cell   • plasma membrane region   • apical plasma membrane   • mitotic spindle   • spindle   • early endosome   • nucleus
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeG1I
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier
FormulaC11 H15 N O3
Molecular Weight209.242
SMILES
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>8GEB_nogp_Chain_R
VWVVGMGIV MSLIVLAIV FGNVLVITA IAKFERLQT VTNYFITSL 
ACADLVMGL AVVPFGAAH ILTKTWTFG NFWCEFWTS IDVLCVTAS 
IETLCVIAV DRYFAITSP FKYQSLLTK NKARVIILM VWIVSGLTS 
FLPIQMHWY RATHQEAIN CYAEETCCD FFTNQAYAI ASSIVSFYV 
PLVIMVFVY SRVFQEAKR QLQKIDKSE GRHKALKTL GIIMGTFTL 
CWLPFFIVN IVHVIQDNL IRKEVYILL NWIGYVNSG FNPLIYCRS 
PDFRIAFQE LL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2RH1AAmineAdrenergicβ2Homo sapiensCarazolol--2.42007-10-30doi.org/10.1126/science.1150577
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
3D4SAAmineAdrenergicβ2Homo sapiensTimolol--2.82008-06-17doi.org/10.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-16doi.org/10.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI118-551--2.842010-08-11doi.org/10.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-11doi.org/10.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiensAlprenolol--3.162010-08-11doi.org/10.1021/ja105108q
3PDSAAmineAdrenergicβ2Homo sapiensFAUC50--3.52011-01-12doi.org/10.1038/nature09665
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-19doi.org/10.1038/nature09648
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.22011-07-20doi.org/10.1038/nature10361
3SN6 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.22011-07-20doi.org/10.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiensCarazolol--3.992012-10-24doi.org/10.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-25doi.org/10.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzyl Isoproterenol--3.12013-09-25doi.org/10.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22013-09-25doi.org/10.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-23doi.org/10.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiensCarazolol--2.482016-01-13doi.org/10.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiensCarazolol--3.82016-01-13doi.org/10.1107/S2059798315021683
5JQHAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-07-13doi.org/10.1038/nature18636
5D6LAAmineAdrenergicβ2Homo sapiensCarazolol--3.22016-08-17doi.org/10.1038/nprot.2017.057
5X7DAAmineAdrenergicβ2Homo sapiensCarazololPubChem 129318963-2.72017-08-16doi.org/10.1038/nature23652
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-14doi.org/10.1038/s41589-018-0145-x
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs(CT)3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6E67 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-26doi.org/10.1126/science.aaw8981
6PRZAAmineAdrenergicβ2Homo sapiensAlprenolol--2.82019-11-13doi.org/10.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiensCarazolol--3.42019-11-13doi.org/10.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-13doi.org/10.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiensAlprenolol--2.42019-11-13doi.org/10.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiensCarvedilol--2.52019-11-13doi.org/10.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI118-551--2.62019-11-13doi.org/10.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiensPropranolol--2.92019-11-13doi.org/10.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-13doi.org/10.1107/S2052252519013137
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.82019-11-20doi.org/10.1038/s41594-019-0330-y
6NI3 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.82019-11-20doi.org/10.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiensAlprenololGTPL11074-3.12020-03-25doi.org/10.1038/s41589-020-0549-2
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/β1/γ23.822020-08-05doi.org/10.1038/s41421-020-0176-9
7BZ2 (No Gprot) AAmineAdrenergicβ2Homo sapiensArformoterol-3.822020-08-05doi.org/10.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/β1/γ23.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHI (No Gprot) AAmineAdrenergicβ2Homo sapiensSalbutamol-3.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/β1/γ23.82020-12-16doi.org/10.1093/nsr/nwaa284
7DHR (No Gprot) AAmineAdrenergicβ2Homo sapiensIsoprenaline-3.82020-12-16doi.org/10.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.12023-04-26doi.org/10.1038/s41467-023-37808-y
8JJ8AAmineAdrenergicβ2Homo sapiensArformoterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-06doi.org/10.1038/s41589-023-01389-0
8GE2AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ13.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GE5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.22024-03-06doi.org/10.1038/s41586-024-07153-1
9CHUAAmineAdrenergicβ2Homo sapiensNorepinephrine--3.492024-11-13doi.org/10.1073/pnas.2414544121
9CHVAAmineAdrenergicβ2Homo sapiens---3.952024-11-13doi.org/10.1073/pnas.2414544121
9U9VAAmineAdrenergicβ2Homo sapiensMETH-Gs/β1/γ22.852025-09-03To be published
9U9V (No Gprot) AAmineAdrenergicβ2Homo sapiensMETH-2.852025-09-03To be published
7XK9AAmineAdrenergicβ2Homo sapiensConstrained IsoproterenolNa-3.42023-04-26doi.org/10.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GDZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GEB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GED (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEG (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8GEH (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-42024-03-06doi.org/10.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEI (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ22.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP2.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--42024-03-06doi.org/10.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8UNLAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNL (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNM (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNN (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNO (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNP (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNR (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNS (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNT (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNU (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg42024-03-06doi.org/10.1038/s41586-024-07153-1
8W1VAAmineAdrenergicβ2Homo sapiensPubChem 171716265--32024-07-17doi.org/10.1021/acs.jmedchem.4c00578
9CHXAAmineAdrenergicβ2Homo sapiensCarazolol--3.52024-11-13doi.org/10.1073/pnas.2414544121
9BUYAAmineAdrenergicβ2Homo sapiensLM189-Gi1/β1/γ22.92025-05-28doi.org/10.1126/sciadv.adq3971
9BUY (No Gprot) AAmineAdrenergicβ2Homo sapiensLM189-2.92025-05-28doi.org/10.1126/sciadv.adq3971
9M55AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-chim(NtGi1-Gs)/β1/γ23.392025-12-1710.1093/pnasnexus/pgaf376
9M55 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-3.392025-12-1710.1093/pnasnexus/pgaf376
9M57AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-chim(NtGi1-Gs)/β1/γ23.652025-12-1710.1093/pnasnexus/pgaf376
9M57 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-3.652025-12-1710.1093/pnasnexus/pgaf376
9L8LAAmineAdrenergicβ2Homo sapiensBI167107AtazanavirGs/β1/γ2 ; Arrestin23.222025-12-31To be published
9L8L (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107Atazanavir3.222025-12-31To be published




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