Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.45 2.05417404
2G.S1.01 4.84083406
3G.S1.02 5.11917445
4G.H1.01 4.482335189
5G.H1.04 4.29833407
6G.H1.07 3.915424199
7G.S2.06 6.08333409
8G.S2.08 7.60292445
9G.S3.01 5.32125444
10G.S3.03 6.80267547
11G.S3.04 8.439174116
12G.S3.06 7.606675115
13G.S3.07 4.238334189
14G.H2.04 2.59083409
15G.H2.06 5.26595739
16G.H2.07 4.552509
17G.H2.09 4.91542488
18G.h2s4.01 6.224119
19G.h2s4.02 4.59292487
20G.S4.04 4.79417409
21G.s4h3.03 3.15125408
22G.s4h3.04 4.49754215
23G.s4h3.08 1.52167408
24G.H3.09 4.15567509
25G.H3.17 5.653505
26G.H3.18 5.664584209
27G.S5.05 4.37417409
28G.S5.06 4.87408
29G.HG.04 2.95792409
30G.HG.14 1.79708405
31G.hgh4.01 3.49208406
32G.hgh4.02 5.157675227
33G.hgh4.05 6.72708407
34G.H4.10 5.282924226
35G.H4.12 4.091254235
36G.S6.02 5.35917407
37G.H5.03 6.199584198
38G.H5.08 4.83133548
39G.H5.25 5.18333407
40G.H5.26 5.57367505
41b.1x1 1.90792404
42b.1x11 4.27542408
43b.h2x1 4.39042405
44b.lhb1x3 2.85125402
45b.lhb1x6 3.996254133
46b.lhb1x9 3.0625403
47b.lhb1x11 4.31125424
48b.l1x3 8.95233579
49b.b2x1 6.568588
50b.b2x5 5.87222607
51b.l3x2 4.64533579
52b.b4x3 4.233334167
53b.b4x6 9.58639679
54b.b5x2 4.1255177
55b.b5x3 5.92278679
56b.b5x5 5.4375405
57b.b5x7 5.2025407
58b.l5x1 3.950675168
59b.l5x5 8.022786119
60b.b6x1 3.225409
61b.b6x5 4.313066246
62b.b7x1 5.31083404
63b.l7x4 3.5275409
64b.b8x4 5.055335166
65b.l8x1 4.213754245
66b.l9x3 6.84778639
67b.l9x6 4.86139638
68b.b10x5 4.16167609
69b.b11x2 4.45083407
70b.l11x2 8.02583439
71b.b12x6 7.60357738
72b.b13x7 7.31133567
73b.l13x3 6.95556669
74b.b15x1 6.40967569
75b.b15x2 6.43917456
76b.l15x2 5.281569
77b.b16x4 7.97167566
78b.b16x5 4.5025405
79b.b16x6 7.93056668
80b.b17x7 7.83625458
81b.l17x3 8.72361659
82b.l17x6 6.39417439
83b.b18x3 4.67083458
84b.b18x5 4.89708405
85b.l18x1 5.742627126
86b.l18x2 5.722084127
87b.b19x2 7.71633556
88b.b19x4 6.145458
89b.l19x2 6.332559
90b.b20x4 10.2007558
91b.b20x6 7.58556
92b.b21x1 7.94625457
93b.b21x5 4.995404
94b.b21x7 4.8605
95b.b22x5 5.83254127
96b.l22x5 6.194176139
97b.b23x6 6.856676147
98b.l23x1 6.66458486
99b.b24x4 7.746674146
100b.b24x6 6.152675148
101b.l24x3 3.98667405
102b.l25x3 8.39933529
103b.l25x6 11.8138488
104b.l27x1 10.336789
105b.l27x2 8.02708429
106b.b28x3 4.43292477
107b.b28x4 7.72708426
108b.b28x6 7.74056629
109g.h1x1 3.91292402
110g.l1x4 5.36125408
111g.h2x11 7.146674126
112g.ctx3 6.86875409
113g.ctx4 3.72792407
114g.ctx6 3.37083406
115g.ctx14 3.72083499
116g.ctx15 6.02292499
117g.ctx16 5.17381798
118NT 18.78471215
1191x30 3.53958416
1201x35 4.656515
1211x42 4.125407
1221x50 4.456509
1231x57 4.46958427
124I1 3.69333826
1252x41 2.24167427
1262x44 3.74967526
1272x50 5.87667529
1282x60 4.56708416
1292x64 6.00233516
130E1 4.8269714
131E1x50 9.29167519
1323x32 5.3175416
1333x34 5.108335305
1343x35 5.13417409
1353x36 5.66958418
1363x51 7.2125107
1373x52 4.318675105
1383x53 5.994726158
1393x55 6.767924108
140I2x51 4.94167446
1414x59 4.46167417
142E2 9.621112113
1435x40 6.00708415
1445x461 5.31042405
1455x47 6.15472618
1465x51 4.63917417
1475x60 4.902924104
1485x68 4.27792445
149I3 4.8551143
1506x44 5.425419
1516x48 6.416518
1526x55 7.64667515
1536x59 4.80625415
154E3 9.26286714
1557x27 5.04467512
1567x34 7.61625414
1577x42 4.05907917
1587x49 5.74625429
1597x50 4.0425409
1607x53 4.85881729
1617x54 4.88286727
162Lig 6.780911110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 25.32772.975NoNo085
2b.b3x1 b.l2x3 25.11057.01333NoNo058
3b.b3x1 b.b6x5 24.89315.27333NoYes056
4b.l2x5 b.l4x2 27.78924.18NoNo054
5b.l4x2 g.ctx15 27.806311.1267NoYes949
6b.l26x5 g.ctx15 31.88335.31NoYes059
7b.l26x5 g.ctx4 45.85076.43NoYes057
8g.ctx3 g.ctx4 47.26733.75667YesYes097
9b.l22x1 g.ctx3 45.98187.605NoYes099
10b.b23x1 b.l22x1 46.16883.75167NoNo059
11b.b23x1 b.lhb1x9 46.52513.56667NoYes053
12b.lhb1x11 b.lhb1x9 52.33252.91833YesYes043
13b.b28x6 b.lhb1x11 52.63143.49YesYes294
14b.b27x3 b.b28x6 43.09388.49167NoYes089
15b.b26x3 b.b27x3 99.11253.685NoNo068
16b.b22x2 b.b26x3 99.92824.50333NoNo086
17b.b22x1 b.b22x2 1003.2NoNo088
18b.b22x1 b.l25x6 97.6223.01833NoYes888
19b.l25x6 b.l27x1 69.672524.1567YesYes889
20b.b2x1 b.l27x1 38.33865.94833YesYes889
21b.b27x3 b.l25x3 77.79767.30167NoYes089
22b.l25x3 b.l27x2 88.00477.14YesYes299
23b.l25x4 b.l27x2 87.58485.98667NoYes259
24I1 b.l25x4 87.44434.16333YesNo265
252x37 I1 24.0933.57NoYes276
262x37 G.H5.22 23.90247.83667NoNo074
273x53 G.H5.22 23.71333.57YesNo084
283x53 G.H5.19 19.54069.64167YesNo088
29G.H5.15 G.H5.19 19.35013.54167NoNo078
30G.H5.15 I2x51 19.16035.74333NoYes076
31b.b28x4 b.b28x6 11.43157.34667YesYes269
32b.b28x4 b.l25x3 11.43588.29667YesYes269
33G.H3.17 b.l25x6 37.84564YesYes058
34G.S5.03 G.S5.05 14.2273.34833NoYes089
35G.H5.10 G.S5.03 15.03333.25NoNo068
36G.H5.10 G.S6.02 15.43716.00667NoYes067
375x68 G.H5.12 11.41023.665YesNo456
38G.H5.17 G.H5.26 11.49293.1NoYes055
39G.H5.20 G.H5.26 17.14234.87NoYes095
40G.H5.20 G.H5.25 19.62383.46NoYes097
413x50 G.H5.25 21.559.71833NoYes097
423x50 7x53 21.94465.145NoYes099
437x53 7x54 22.32113.64YesYes297
441x57 7x54 59.23926.02YesYes277
451x57 I1 59.13873.295YesYes276
46b.b6x1 b.l9x6 94.16654.59167YesYes098
47G.H2.10 b.b6x1 93.87522.97NoYes079
48G.H2.09 G.H2.10 62.56814.17833YesNo887
49G.H2.09 G.H3.17 31.32746.34667YesYes085
50G.H2.09 b.l27x1 31.35594.05667YesYes889
51G.H2.10 b.b2x1 31.47644.48167NoYes878
52G.H2.06 b.l9x6 84.63733.58YesYes398
53G.H2.06 b.l17x6 41.93736.685YesYes399
54G.H2.06 b.b18x1 41.93753.03333YesNo099
55G.S4.04 G.S5.04 10.4263.04333YesNo099
56b.l17x6 b.l19x1 41.80536.875YesNo099
57b.l17x5 b.l19x1 83.1042.94167NoNo069
58b.l17x5 b.l19x2 82.6735.39833NoYes069
59b.l17x3 b.l19x2 57.36764.2YesYes599
60b.b19x4 b.l17x3 32.49549.125YesYes589
61b.b19x4 b.b20x6 21.79167.34833YesYes586
62b.b17x7 b.b20x6 61.34738.93333YesYes586
63b.b17x7 b.b21x1 58.70753.185YesYes587
64b.1x19 b.b21x1 52.08037.74NoYes067
65b.1x15 b.1x19 46.71922.50667NoNo076
66b.1x12 b.1x15 44.03762.90667NoNo067
67b.1x12 g.h1x11 31.96263.055NoNo069
68b.1x11 g.h1x11 27.93485.53667YesNo089
69b.b18x1 b.l19x1 41.729810.5467NoNo099
70b.b20x4 b.l17x3 23.119616.3617YesYes589
71b.b20x4 b.b20x6 43.5715.87833YesYes586
72b.b20x2 b.l19x2 23.99886.02167NoYes069
73b.b20x2 b.b20x4 23.11996.25167NoYes068
74b.1x12 b.1x16 10.76471.65167NoNo064
75b.b3x2 b.b4x6 11.52585.88167NoYes059
76b.b2x5 b.b3x2 11.75169.30167YesNo075
77b.b2x4 b.b6x5 11.32883.45167NoYes066
78b.b10x4 b.b2x4 11.101513.5433NoNo066
79b.b2x5 b.l26x1 12.759610.3133YesNo077
80b.l26x3 b.l26x5 13.87439.47333NoNo075
81b.l11x1 b.l9x6 15.86626.75667NoYes398
82b.b11x6 b.l11x1 15.63863.40167NoNo399
83b.b11x6 b.l9x3 14.402113.9467NoYes399
84b.b12x6 b.l9x3 12.93735.82YesYes389
85b.b11x2 b.b12x6 11.23182.93333YesYes078
86b.b10x2 b.b10x4 10.8742.78667NoNo066
87b.b10x2 b.b14x3 10.64635.28833NoNo065
88b.b11x5 b.b14x3 10.41855.755NoNo065
89b.b18x3 b.b19x4 10.2773.29333YesYes588
90b.l21x7 b.l23x1 11.91243.88833NoYes056
91b.b23x6 b.l23x2 10.97544.6YesNo078
92b.l21x7 b.l23x2 11.58467.26167NoNo058
93b.1x11 b.1x7 22.5622.65167YesNo088
94b.1x7 g.h1x8 19.87471.90167NoNo087
95b.1x4 g.h1x8 17.18671.49NoNo087
96b.1x4 g.h1x5 14.49812.42833NoNo086
97g.h1x1 g.h1x5 11.80886.265YesNo026
982x46 7x54 34.0964.69NoYes297
992x46 2x50 28.05452.94NoYes299
1002x50 7x46 30.03218.34333YesNo098
1012x53 7x46 29.84633.25167NoNo078
1022x53 7x42 24.7973.71NoYes077
1037x42 Lig 21.04427.67833YesYes170
104E2 Lig 13.26987.05833YesYes130
1057x49 7x53 12.534.40833YesYes299
1066x48 7x45 15.22699.06167YesNo089
1077x45 7x49 15.96127.18NoYes099
108b.l26x1 b.l26x3 12.95515.30167NoNo2577
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT48.53331YesYes5522
E3NT20.461YesYes4522
E2NT54.41671YesYes3512
5x38NT4.746671NoYes2522
7x27NT3.338331YesYes2522
7x31NT7.386671NoYes4522
E1NT3.666671YesYes4512
1x311x354.758331NoYes5522
1x312x643.831671NoYes5621
1x31E13.5251NoYes5421
1x352x649.963331YesYes5621
1x427x425.051670YesYes7721
2x563x324.4950NoYes6621
2x577x424.688330NoYes8721
2x602x644.493331YesYes6611
2x603x324.613331YesYes6611
2x607x423.323331YesYes6711
2x63E14.708330NoYes5421
2x64E15.3051YesYes6411
2x64Lig6.418331YesYes6010
E1E2x513.501671YesNo4411
7x35E19.853330NoYes5421
E1Lig3.228331YesYes4010
E1x49E23.436671NoYes4321
3x25E25.568331NoYes9321
3x29Lig6.768330NoYes5010
3x327x423.1251YesYes6711
3x32Lig9.036671YesYes6010
3x367x414.311YesNo8812
3x367x423.091YesYes8711
3x36Lig11.20831YesYes8010
E2E224.64331YesYes3311
E2E2x515.073331YesNo3411
E2x51Lig5.446671NoYes4010
E2x52Lig6.3150NoYes4010
5x44E28.573331NoYes6321
6x55E25.056671YesYes5321
7x34E28.396671YesYes4321
7x38E23.451671NoYes5311
E2Lig7.058331YesYes3010
5x41E22.948331NoYes4321
6x58E24.661NoYes4321
6x62E28.711671NoYes3321
7x27E23.831671YesYes2321
E2E35.471671YesYes3412
5x38E23.071NoYes2321
6x59E23.038331YesYes5321
5x416x5512.4051NoYes4522
5x416x598.941NoYes4522
5x445x4613.693331NoYes6522
6x556x594.811671YesYes5522
6x557x3412.82831YesYes5422
6x627x275.668331NoYes3222
E3E39.083331YesYes4422
7x27E38.283331YesYes2422
7x317x355.973331NoNo4522
7x347x384.873331YesNo4521
7x38Lig5.593331NoYes5010
7x42Lig7.678331YesYes7010
2x60Lig5.838331YesYes6010
2x537x423.710NoYes7721
3x22E26.976671NoYes3321
3x365x4614.071YesYes8512
5x40E2x525.811YesNo5421
5x40E29.051YesYes5321
7x31E23.966671NoYes4321
6x556x583.131671YesNo5422
7x417x423.326671NoYes8721
1x397x422.538330NoYes8721

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
100.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
100.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
100.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
91.67Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
90.91Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
90.91Consensushca_onOrthosteric Ligandhca2_on
84.62Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
84.62Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
83.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
83.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
83.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
83.33Single8K5DGSK2560738K5D-HCA2-GSK256073
76.92Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
76.92Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
75.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
75.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
75.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
75.00Single8K5CAcipimox8K5C-HCA2-Acipimox
72.73Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
72.73Single8K5BNiacin8K5B-HCA2-Niacin
72.73Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
69.23Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
69.23Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
66.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
66.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
66.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
66.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
66.67Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
63.64Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
62.50Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
61.54Single8IHKAcifran8IHK-HCA3-Acifran
58.33Single3OE9IT1t3OE9-CXCR4-IT1t
58.33Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
57.14Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
56.25Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
55.56Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
55.56Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
55.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
53.85Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
53.85Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
53.85Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
53.85Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
53.85Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
53.85Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
53.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
53.33Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
52.94Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
52.63Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
52.63Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
50.00Single3OE6IT1t3OE6-CXCR4-IT1t
50.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
50.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
50.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
50.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
50.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
50.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
47.83Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
47.62Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
47.62Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
47.37Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
47.37Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.06Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
47.06Single7K15MKD0467K15-BLT1-MKD046-Na
47.06Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
47.06Single8XYIVUF106618XYI-CXCR3-VUF10661
46.67Single4YAYZD-71554YAY-AT1-ZD-7155
46.67Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
46.67Single7UL4Alvimopan7UL4-μ-Alvimopan
46.67Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
46.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
46.67Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
46.67Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
46.15Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
46.15Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
46.15Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
46.15Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
45.83Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
45.45Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
45.45Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
45.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
45.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
45.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
45.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
45.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
44.44Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
44.44Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
44.44Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
44.44Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
44.44Consensusprostanoid_offOrthosteric Ligandep_off dp_off
43.75Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
43.75Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
43.75Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
43.75Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
43.75Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
43.75Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
43.75Consensusblt_offOrthosteric Ligandblt1_off
43.75Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
43.75Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
43.48Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
42.86Single3ODUIT1t3ODU-CXCR4-IT1t
42.86Single5ZKQABT-4915ZKQ-PAF-ABT-491
42.86Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
42.86Single8Y0HVUF114188Y0H-CXCR3-VUF11418
42.86Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
42.86Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
42.11Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
42.11Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
42.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
42.11Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
41.67Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
41.67Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
41.67Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
41.67Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
41.18Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
41.18Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
41.18Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.18Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
41.18Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
41.18Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
41.18Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
40.91Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.91Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
40.91Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
40.00Single2YDOAdenosine2YDO-A2A-Adenosine
40.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
40.00Single4XT1Fractalkine4XT1-US28-Fractalkine
40.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
40.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
40.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
40.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
40.00Single6TPGEMPA6TPG-OX2-EMPA
40.00Single6V9SGTPL114036V9S-OX1-GTPL11403
40.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
40.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
40.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
40.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
40.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
40.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
40.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
40.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
40.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
40.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
40.00Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
40.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
39.13Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
39.13Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
39.13Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
39.13Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
39.13Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
38.89Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
38.89Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
38.89Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
38.89Single7DFPSpiperone7DFP-D2-Spiperone
38.89Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
38.89Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
38.89Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
38.89Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
38.89Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
38.89Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.89Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
38.89Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
38.89Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
38.89Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.46Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
38.46Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.46Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.46Consensusbombesin_onOrthosteric Ligandbb2_on
38.46Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
38.46Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.10Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
38.10Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
38.10Single7XNACYN1548067XNA-SST2-CYN154806
38.10Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
38.10Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
38.10Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
38.10Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.10Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
37.50Single2Y04Salbutamol2Y04-β1-Salbutamol
37.50Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
37.50Single4XT3Fractalkine4XT3-US28-Fractalkine
37.50Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
37.50Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
37.50Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
37.50Single6TOTLemborexant6TOT-OX1-Lemborexant
37.50Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
37.50Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.50Single7V3ZCP559407V3Z-CB1-CP55940
37.50Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
37.50Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
37.50Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
37.50Single8T1WCVN4248T1W-GPR6-CVN424
37.50Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
37.50Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
37.50Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
37.50Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
37.50Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
37.50Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
37.50Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
37.50Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
36.84Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
36.84Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
36.84Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
36.84Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
36.84Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
36.84Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
36.84Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
36.84Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
36.84Consensuscck_onOrthosteric Ligandccka_on cckb_on
36.84Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
36.84Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
36.36Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Consensusangiotensin_onOrthosteric Ligandat1_on
36.36Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.36Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
36.36Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
36.36Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.36Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
36.36Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
36.36Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
36.36Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
36.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
36.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
35.71Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
35.71Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
35.71Consensusgq_nucleotideOrthosteric Ligandgq_p2y
35.71Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
35.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
35.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
35.29Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
35.29Single5WQCEMPA5WQC-OX2-EMPA
35.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
35.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
35.29Single6D26Fevipiprant6D26-DP2-Fevipiprant
35.29Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.29Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
35.29Single6TP6Filorexant6TP6-OX1-Filorexant
35.29Single7C4SS1P7C4S-S1P3-S1P
35.29Single7C61Ergotamine7C61-5-HT1B-Ergotamine
35.29Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
35.29Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
35.29Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
35.29Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
35.29Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
35.29Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
35.29Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
35.29Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
35.29Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
35.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
35.29Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.29Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
35.29Consensusdp_offOrthosteric Liganddp2_off
35.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
35.29Consensusep_offOrthosteric Ligandep4_off
35.29Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
35.29Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
35.29Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
35.29Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
35.29Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
35.29Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.29Consensustrace-amine_onOrthosteric Ligandta1_on
35.00Single4UG2CGS216804UG2-A2A-CGS21680
35.00Single5ZTYAM102575ZTY-CB2-AM10257
35.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
35.00Single7SK9CCX6627SK9-ACKR3-CCX662
35.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
35.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
35.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
35.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
35.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
35.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
35.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
35.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
35.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
35.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
35.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
34.78Single6JODAngiotensin II6JOD-AT2-Angiotensin II
34.78Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
34.78Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.78Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
34.78Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
34.78Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
34.78Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
34.78Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
34.78Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.78Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
34.78Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.78Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.78Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.78Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
34.62Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
34.62Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
34.62Consensusbradykinin_onOrthosteric Ligandbk2_on
34.62Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
34.62Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
33.33Single4DJHJDTic4DJH-κ-JDTic
33.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single5XR8AM8415XR8-CB1-AM841
33.33Single6B73MP11046B73-κ-MP1104
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
33.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
33.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
33.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
33.33Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
33.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
33.33Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
33.33Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
33.33Single7F8XNN90567F8X-CCKA-NN9056
33.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
33.33Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
33.33Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
33.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
33.33Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
33.33Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
33.33Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
33.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
33.33Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
33.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
33.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
33.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
33.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
33.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
33.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
33.33Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
33.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
33.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
33.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
33.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
33.33Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
33.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
33.33Single8IWESpermidine8IWE-TA9-Spermidine
33.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
33.33Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
33.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
33.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
33.33Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
33.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
33.33Single8WDTphotoNECA8WDT-A2A-photoNECA
33.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
33.33Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
33.33Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
33.33Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
33.33Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
33.33Consensusa2_onOrthosteric Liganda2b_on
33.33Consensusa2_on_gpOrthosteric Liganda2b_on_gp
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
33.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
33.33Consensusangiotensin_offOrthosteric Ligandat1_off
33.33Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
33.33Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
33.33Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
33.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
33.33Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
33.33Consensuslpl_onOrthosteric Ligands1p_on lpa_on
33.33Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
33.33Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
33.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
33.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
33.33Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
33.33Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
33.33Consensussomatostatin_offOrthosteric Ligandsst2_off
33.33Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
32.00Single6FJ3PTH6FJ3-PTH1-PTH
32.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
32.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
32.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
32.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
31.82Single3QAKUK-4320973QAK-A2A-UK-432097
31.82Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
31.82Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.82Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
31.82Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
31.82Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
31.82Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
31.82Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.58Single4AMIBucindolol4AMI-β1-Bucindolol
31.58Single4LDEBI1671074LDE-β2-BI167107
31.58Single4RWADIPP-NH24RWA-δ-DIPP-NH2
31.58Single5X33BIIL2605X33-BLT1-BIIL260
31.58Single6A93Risperidone6A93-5-HT2A-Risperidone
31.58Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
31.58Single6OS2TRV0266OS2-AT1-TRV026
31.58Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
31.58Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
31.58Single6ZG4HTL00099366ZG4-M1-HTL0009936
31.58Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
31.58Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
31.58Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
31.58Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single7YITNalfurafine7YIT-κ-Nalfurafine
31.58Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
31.58Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
31.58Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
31.58Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
31.58Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
31.58Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
31.58Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
31.58Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
31.58Consensusalpha1_offOrthosteric Ligandalpha1a_off
31.58Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
31.58Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
31.58Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
31.58Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.58Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
31.58Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
31.58Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
31.58Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
31.58Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
31.58Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
31.58Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
31.58Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
31.58Consensuslpl_offOrthosteric Ligands1p_off lpa_off
31.58Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.58Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.58Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
31.25Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
31.25Single6KUXRS-799486KUX-α2a-RS-79948
31.25Single6PS0S-Carazolol6PS0-β2-S-Carazolol
31.25Single6PS4ICI118-5516PS4-β2-ICI118-551
31.25Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
31.25Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
31.25Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.25Single6TP3Nemorexant6TP3-OX1-Nemorexant
31.25Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
31.25Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
31.25Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
31.25Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single7UL3Famotidine7UL3-H2-Famotidine
31.25Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
31.25Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
31.25Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
31.25Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
31.25Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
31.25Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
31.25Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
31.25Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
31.25Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
31.25Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
31.25Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
31.25Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
31.25Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
31.25Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
31.25Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
31.25Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
31.25Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
31.25Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.25Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
31.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
30.77Single3OE8IT1t3OE8-CXCR4-IT1t
30.77Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
30.77Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
30.77Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
30.77Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
30.77Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.77Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
30.43Single5WF5UK-4320975WF5-A2A-UK-432097
30.43Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
30.43Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
30.43Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
30.43Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
30.43Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
30.43Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
30.43Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
30.43Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
30.43Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
30.43Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.43Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.43Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
30.43Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
30.43Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
30.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
30.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
30.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.00Single5X93K-87945X93-ETB-K-8794
30.00Single6IBLArformoterol6IBL-β1-Arformoterol
30.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
30.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
30.00Single7EZCUKA7EZC-A2A-UKA
30.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
30.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
30.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
30.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
30.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
30.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
30.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
30.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
30.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
30.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
30.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
30.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
30.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.00Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
30.00Consensuschemerin_onOrthosteric Ligandcml1_on
30.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
30.00Consensusendothelin_offOrthosteric Ligandetb_off
30.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
30.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
29.63Single6IGLIRL16206IGL-ETB-IRL1620
29.63Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.63Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
29.63Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
29.63Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
29.41Single3NY8ICI118-5513NY8-β2-ICI118-551
29.41Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
29.41Single4GBRS-Carazolol4GBR-β2-S-Carazolol
29.41Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
29.41Single4QKX35V4QKX-β2-35V
29.41Single5DHGC-355DHG-NOP-C-35
29.41Single5DHHSB-6121115DHH-NOP-SB-612111
29.41Single5TGZAM65385TGZ-CB1-AM6538
29.41Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
29.41Single6DRXLisuride6DRX-5-HT2B-Lisuride
29.41Single6GPSMK08126GPS-CCR2-MK0812
29.41Single6H7MSalbutamol6H7M-β1-Salbutamol
29.41Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
29.41Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
29.41Single6PS1Timolol6PS1-β2-Timolol
29.41Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
29.41Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
29.41Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
29.41Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
29.41Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
29.41Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
29.41Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
29.41Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
29.41Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
29.41Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
29.41Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
29.41Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
29.41Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
29.41Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
29.41Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
29.41Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
29.41Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.41Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
29.41Single7YXAONO-54306087YXA-S1P5-ONO-5430608
29.41Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
29.41Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
29.41Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
29.41Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
29.41Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
29.41Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
29.41Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
29.41Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
29.41Single8JJOAlprenolol8JJO-β2-Alprenolol
29.41Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
29.41Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
29.41Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
29.41Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
29.41Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
29.41Single9CHXS-Carazolol9CHX-β2-S-Carazolol
29.41Consensusa3_onOrthosteric Liganda3a_on
29.41Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
29.41Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Consensusblt_onOrthosteric Ligandblt1_on
29.41Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
29.41Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
29.41Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
29.41Consensusdopamine_offOrthosteric Ligandd2_off d3_off
29.41Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
29.41Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
29.41Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.41Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.41Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
29.41Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
29.41Consensusleukotriene_onOrthosteric Ligandblt_on
29.41Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
29.17Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
29.17Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
29.17Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
29.17Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
29.17Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.17Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
29.17Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
29.17Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
28.57Single3NY9ICI118-5513NY9-β2-ICI118-551
28.57Single5EE7MK08935EE7-Glucagon-MK0893
28.57Single5GLHEndothelin-15GLH-ETB-Endothelin-1
28.57Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
28.57Single5WF6UK-4320975WF6-A2A-UK-432097
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
28.57Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
28.57Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
28.57Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
28.57Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
28.57Single7XN9L-054,5227XN9-SST2-L-054,522
28.57Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
28.57Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
28.57Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
28.57Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
28.57Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
28.57Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
28.57Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
28.57Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
28.57Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
28.57Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
28.57Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
28.57Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
28.57Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.57Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
28.57Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
28.57Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
28.57Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
28.57Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.57Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
28.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
28.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
28.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
28.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
28.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
28.00Single8ZRTET-18ZRT-ETB-ET-1
28.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
28.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
28.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
28.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
27.78Single2RH1S-Carazolol2RH1-β2-S-Carazolol
27.78Single2YCWS-Carazolol2YCW-β1-S-Carazolol
27.78Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
27.78Single5C1MBU725C1M-μ-BU72
27.78Single5D6LS-Carazolol5D6L-β2-S-Carazolol
27.78Single5JQHS-Carazolol5JQH-β2-S-Carazolol
27.78Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
27.78Single5WIUNemonapride5WIU-D4-Nemonapride
27.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
27.78Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
27.78Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
27.78Single6GPXMK08126GPX-CCR2-MK0812
27.78Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
27.78Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
27.78Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
27.78Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
27.78Single6PS6Timolol6PS6-β2-Timolol
27.78Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
27.78Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
27.78Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
27.78Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
27.78Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7W41PD1762527W41-BB2-PD176252
27.78Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
27.78Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
27.78Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
27.78Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
27.78Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
27.78Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
27.78Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
27.78Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8JXSPF-61428JXS-D1-PF-6142
27.78Single8S4DCMF-0198S4D-Apelin-CMF-019
27.78Single8TF5Oleic acid8TF5-GPR6-Oleic acid
27.78Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
27.78Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
27.78Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
27.78Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
27.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
27.78Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
27.78Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
27.78Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
27.78Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
27.78Consensusa3_on_gpOrthosteric Liganda3a_on_gp
27.78Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
27.78Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
27.78Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
27.78Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
27.78Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
27.78Consensusamine_offonOrthosteric Ligandamine_off amine_on
27.78Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
27.78Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
27.78Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
27.78Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
27.78Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
27.78Consensusbombesin_offOrthosteric Ligandbb2_off
27.78Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.59Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
27.27Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
27.27Single4IARErgotamine4IAR-5-HT1B-Ergotamine
27.27Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
27.27Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
27.27Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.27Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
27.27Single7QA8Peptide7QA8-STE2-Peptide
27.27Single7QA8Peptide7QA8-STE2-Peptide
27.27Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
27.27Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
27.27Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
27.27Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
27.27Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
27.27Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
26.92Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
26.92Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.92Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
26.92Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
26.92Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
26.92Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
26.92Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
26.92Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
26.92Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
26.92Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
26.92Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
26.92Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
26.92Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
26.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
26.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
26.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
26.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
26.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
26.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
26.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
26.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
26.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
26.67Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
26.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
26.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
26.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
26.67Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
26.67Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
26.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
26.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
26.67Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
26.67Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
26.32Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.32Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.32Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.32Single5D5AS-Carazolol5D5A-β2-S-Carazolol
26.32Single5D5BS-Carazolol5D5B-β2-S-Carazolol
26.32Single5XRAAM115425XRA-CB1-AM11542
26.32Single6J21Aprepitant6J21-NK1-Aprepitant
26.32Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
26.32Single6WGTLSD6WGT-5-HT2A-LSD
26.32Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
26.32Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.32Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.32Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
26.32Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.32Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.32Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
26.32Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
26.32Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
26.32Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
26.32Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
26.32Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
26.32Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.32Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
26.32Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
26.32Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
26.32Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
26.32Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
26.32Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
26.32Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
26.32Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
26.32Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
26.32Single9BJKNAM9BJK-μ-Naloxone-NAM
26.32Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
26.32Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
26.32Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
26.32Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.32Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.32Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.32Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.32Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
26.32Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
26.32Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.32Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.09Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
26.09Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
26.09Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
26.09Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
26.09Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.09Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.09Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.09Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
25.93Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
25.93Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
25.93Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.93Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
25.93Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
25.93Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
25.93Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
25.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
25.00Single3D4STimolol3D4S-β2-Timolol
25.00Single3OE0CVX153OE0-CXCR4-CVX15
25.00Single3PWHZM-2413853PWH-A2A-ZM-241385
25.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
25.00Single4N4WSANT-14N4W-SMO-SANT-1
25.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.00Single4XESNeurotensin4XES-NTS1-Neurotensin
25.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
25.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
25.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
25.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
25.00Single6KQICP559406KQI-CB1-CP55940-Org27569
25.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
25.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Single6MXTSalmeterol6MXT-β2-Salmeterol
25.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
25.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
25.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
25.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
25.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
25.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
25.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
25.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
25.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
25.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
25.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
25.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
25.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
25.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
25.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
25.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
25.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
25.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
25.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
25.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
25.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
25.00Single8JJ8Formoterol8JJ8-β2-Formoterol
25.00Single8JJLOlodaterol8JJL-β2-Olodaterol
25.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
25.00Single8JWY2-1188JWY-A2A-2-118
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
25.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
25.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
25.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
25.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
25.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
25.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
25.00Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
25.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
25.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
25.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
25.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
25.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
25.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
25.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
25.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.00Consensuslpa_offOrthosteric Ligandlpa1_off
25.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
25.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.00Consensusorexin_onOrthosteric Ligandox2_on
25.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.14Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
24.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
24.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
24.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
24.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
24.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
24.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
24.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
24.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
24.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
23.81Single4BUONeurotensin4BUO-NTS1-Neurotensin
23.81Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
23.81Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
23.81Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
23.81Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
23.81Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
23.81Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
23.81Single6H7LDobutamine6H7L-β1-Dobutamine
23.81Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
23.81Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
23.81Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
23.81Single7UM4AS26747237UM4-5-HT5A-AS2674723
23.81Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
23.81Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
23.81Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
23.81Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
23.81Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
23.81Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
23.81Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.81Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.81Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
23.81Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
23.81Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
23.81Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
23.81Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
23.53Single4MBSMaraviroc4MBS-CCR5-Maraviroc
23.53Single6IQLL7458706IQL-D4-L745870
23.53Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
23.53Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
23.53Single6MH8ZM-2413856MH8-A2A-ZM-241385
23.53Single6PS5S-Propranolol6PS5-β2-S-Propranolol
23.53Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
23.53Single6VI4JDTic6VI4-κ-JDTic
23.53Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
23.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
23.53Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
23.53Single7AROLUF58337ARO-A2A-LUF5833-Na
23.53Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
23.53Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
23.53Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
23.53Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
23.53Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
23.53Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
23.53Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
23.53Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
23.53Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
23.53Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.53Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
23.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
23.53Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
23.53Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
23.53Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
23.53Single8K2WAMG4878K2W-CXCR3-AMG487
23.53Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
23.53Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
23.53Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
23.53Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
23.53Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
23.53Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
23.53Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
23.53Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
23.53Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
23.53Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
23.53Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
23.53Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
23.53Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
23.53Consensusalpha1_onOrthosteric Ligandalpha1a_on
23.53Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
23.53Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
23.53Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
23.53Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
23.53Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
23.53Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
23.53Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
23.33Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
23.33Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
23.08Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.08Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
23.08Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.08Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.08Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
23.08Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
23.08Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Single8PWNTheophylline8PWN-A2A-Theophylline
23.08Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
23.08Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
22.73Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.73Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.73Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
22.73Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
22.73Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
22.73Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
22.73Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
22.73Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
22.73Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8QJ2pN1628QJ2-MC4-pN162-Gs
22.73Single8X5YAstemizole8X5Y-H1-Astemizole
22.73Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
22.73Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
22.22Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
22.22Single2Y01Dobutamine2Y01-β1-Dobutamine
22.22Single2Y02Carmoterol2Y02-β1-Carmoterol
22.22Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
22.22Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
22.22Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
22.22Single4EJ4Naltrindole4EJ4-δ-Naltrindole
22.22Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
22.22Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
22.22Single5T04Neurotensin5T04-NTS1-Neurotensin
22.22Single5UENDU1725UEN-A1-DU172
22.22Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
22.22Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
22.22Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
22.22Single6D27CAY104716D27-DP2-CAY10471
22.22Single6IIVDaltroban6IIV-TP-Daltroban
22.22Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
22.22Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
22.22Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
22.22Single7BU7BI1671077BU7-β1-BI167107
22.22Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
22.22Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
22.22Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.22Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
22.22Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
22.22Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.22Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
22.22Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
22.22Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
22.22Single7SK3CXCL127SK3-ACKR3-CXCL12
22.22Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
22.22Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
22.22Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
22.22Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
22.22Single7WC7Lisuride7WC7-5-HT2A-Lisuride
22.22Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.22Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
22.22Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
22.22Single8CU6LJ-45178CU6-A2A-LJ-4517
22.22Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
22.22Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
22.22Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
22.22Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
22.22Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
22.22Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
22.22Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
22.22Single8JXRLSD8JXR-D1-LSD
22.22Single8RLNLUF58348RLN-A2A-LUF5834
22.22Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
22.22Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
22.22Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
22.22Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
22.22Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
22.22Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
22.22Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
22.22Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
22.22Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
22.22Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.22Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
22.22Consensus5ht5_onOrthosteric Ligand5ht5a_on
22.22Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
22.22Consensusalpha2_onOrthosteric Ligandalpha2b_on
22.22Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
22.22Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
22.22Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
22.22Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.22Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
22.22Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
22.22Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
22.22Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
22.22Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
22.22Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
21.88Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
21.88Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
21.88Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
21.88Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
21.88Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
21.74Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.74Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
21.74Single8IEBA1LYA8IEB-GPR156-A1LYA
21.74Single8IEIA1LYA8IEI-GPR156-A1LYA
21.74Single8IEPA1LYA8IEP-GPR156-A1LYA
21.74Single8IEPA1LYA8IEP-GPR156-A1LYA
21.74Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
21.74Single8KIGSHU91198KIG-MC3-SHU9119-Ca
21.74Single8WKYPG-9348WKY-MC4-PG-934
21.74Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
21.74Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
21.74Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
21.74Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
21.43Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
21.43Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
21.43Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
21.43Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
21.43Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
21.43Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
21.43Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.43Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
21.43Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
21.43Single8A2OTheophylline8A2O-A2A-Theophylline-Na
21.43Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
21.43Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
21.43Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
21.43Single9CHUNoradrenaline9CHU-β2-Noradrenaline
21.43Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
21.43Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.43Consensussensory_onOrthosteric Ligandopsins_on
21.05Single2Y00Dobutamine2Y00-β1-Dobutamine
21.05Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
21.05Single5CGCHTL142425CGC-mGlu5-HTL14242
21.05Single5N2RPSB-365N2R-A2A-PSB-36-Na
21.05Single5N2SPSB365N2S-A1-PSB36
21.05Single5TVNLSD5TVN-5-HT2B-LSD
21.05Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
21.05Single6E67BI1671076E67-β2-BI167107-Gs (fused)
21.05Single6LUQHaloperidol6LUQ-D2-Haloperidol
21.05Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
21.05Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
21.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
21.05Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
21.05Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
21.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
21.05Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
21.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.05Single7WC6LSD7WC6-5-HT2A-LSD
21.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
21.05Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
21.05Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
21.05Single8ZMFA1L108ZMF-5-HT2C-A1L10
21.05Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
21.05Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
21.05Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
21.05Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
21.05Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
21.05Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
21.05Consensusadenosine_offOrthosteric Liganda1_off a2_off
21.05Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
21.05Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
21.05Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.05Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.05Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
21.05Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
20.83Single6HLOAprepitant6HLO-NK1-Aprepitant
20.83Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
20.83Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.83Single7SK5CXCL127SK5-ACKR3-CXCL12
20.83Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
20.83Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8IEBA1LYA8IEB-GPR156-A1LYA
20.83Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.83Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
20.83Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
20.83Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.83Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.69Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
20.69Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.69Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.69Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.69Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
20.69Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
20.69Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.69Consensusendothelin_onOrthosteric Ligandetb_on eta_on
20.69Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
20.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
20.00Single3P0GBI1671073P0G-β2-BI167107
20.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
20.00Single3UZAGTPL92363UZA-A2A-GTPL9236
20.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
20.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
20.00Single4U15Tiotropium4U15-M3-Tiotropium
20.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
20.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
20.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
20.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
20.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
20.00Single6J20Aprepitant6J20-NK1-Aprepitant
20.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
20.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
20.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Single6OL9Tiotropium6OL9-M5-Tiotropium
20.00Single6OS1TRV0266OS1-AT1-TRV026
20.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.00Single6PT2KGCHM076PT2-δ-KGCHM07
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
20.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
20.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
20.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7PX4PSB-21137PX4-A2A-PSB-2113
20.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
20.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
20.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
20.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
20.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
20.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
20.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
20.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
20.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8EA0Iperoxo8EA0-M3-Iperoxo
20.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
20.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
20.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
20.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
20.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
20.00Single8XVLZibotentan8XVL-ETA-Zibotentan
20.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
20.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
20.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
20.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
20.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
20.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
20.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
20.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
20.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
20.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.00Consensuslpa_onOrthosteric Ligandlpa1_on
20.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
20.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
20.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
20.00Consensusneurotensin_onOrthosteric Ligandnts1_on
20.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
20.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
20.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
20.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
20.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
19.35Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
19.35Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
19.35Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
19.35Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
19.35Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
19.35Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
19.35Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
19.35Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
19.35Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
19.23Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
19.23Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
19.23Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
19.23Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
19.05Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
19.05Single5CXVTiotropium5CXV-M1-Tiotropium
19.05Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
19.05Single6CM4Risperidone6CM4-D2-Risperidone
19.05Single6IIURamatroban6IIU-TP-Ramatroban
19.05Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
19.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
19.05Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
19.05Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
19.05Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
19.05Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
19.05Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
19.05Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
19.05Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
19.05Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
19.05Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
19.05Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.75Single3PBLEticlopride3PBL-D3-Eticlopride
18.75Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
18.75Single5L7IVismodegib5L7I-SMO-Vismodegib
18.75Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
18.75Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.75Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
18.75Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.75Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
18.75Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
18.75Single7SRQLSD7SRQ-5-HT2B-LSD
18.75Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
18.75Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
18.75Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
18.75Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
18.75Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
18.75Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
18.75Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
18.75Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
18.75Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.75Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
18.75Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9B9Y7DY9B9Y-CB1-7DY
18.75Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
18.75Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
18.75Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
18.75Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
18.75Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
18.52Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
18.52Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
18.52Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
18.52Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.18Single5CGDHTL142425CGD-mGlu5-HTL14242
18.18Single6K1QIRL25006K1Q-ETB-IRL2500
18.18Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
18.18Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
18.18Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
18.18Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
18.18Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
18.18Single8XVJMacitentan8XVJ-ETA-Macitentan
18.18Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
18.18Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.65Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
17.65Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
17.65Single4BWBNeurotensin4BWB-NTS1-Neurotensin
17.65Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
17.65Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
17.65Single5U09Taranabant5U09-CB1-Taranabant
17.65Single6DS0Ly2660976DS0-5-HT2B-Ly266097
17.65Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.65Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
17.65Single6ME2Ramelteon6ME2-MT1-Ramelteon
17.65Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.65Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.65Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
17.65Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
17.65Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
17.65Single7F8YDevazepide7F8Y-CCKA-Devazepide
17.65Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
17.65Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.65Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
17.65Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
17.65Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
17.65Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
17.65Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
17.65Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
17.65Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
17.65Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
17.65Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.65Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.65Single9BA0A1AKN9BA0-CB1-A1AKN
17.65Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
17.65Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
17.65Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
17.65Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
17.65Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
17.65Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
17.65Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
17.39Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
17.39Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
17.39Single6PT3DPI-2876PT3-δ-DPI-287
17.39Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.39Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
17.39Single8IEIA1LYA8IEI-GPR156-A1LYA
17.39Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.39Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
17.39Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.24Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
17.24Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
17.14Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.14Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
16.67Single3REYXAC3REY-A2A-XAC
16.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
16.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
16.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
16.67Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
16.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.67Single5IUBQ274563445IUB-A2A-Q27456344-Na
16.67Single5JTBZM-2413855JTB-A2A-ZM-241385
16.67Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
16.67Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
16.67Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
16.67Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
16.67Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
16.67Single6A94Zotepine6A94-5-HT2A-Zotepine
16.67Single6AQFZM-2413856AQF-A2A-ZM-241385
16.67Single6TPKRetosiban6TPK-OT-Retosiban
16.67Single6TPNHTL66416TPN-OX2-HTL6641
16.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
16.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
16.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
16.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
16.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
16.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
16.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
16.67Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
16.67Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
16.67Single7T32ZM-2413857T32-A2A-ZM-241385
16.67Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
16.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
16.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
16.67Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
16.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
16.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
16.67Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
16.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
16.67Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
16.67Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
16.67Single8XWNCXCL88XWN-CXCR2-CXCL8
16.67Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
16.67Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
16.67Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Consensusa2_offOrthosteric Liganda2a_off
16.67Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
16.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.67Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.67Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
16.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
16.67Consensussensory_offOrthosteric Ligandopsins_off
16.67Consensusvasop-oxy_offOrthosteric Ligandot_off
16.13Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
16.13Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
16.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
16.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
16.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
16.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
16.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
15.79Single3EMLZM-2413853EML-A2A-ZM-241385
15.79Single4DAJTiotropium4DAJ-M3-Tiotropium
15.79Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.79Single4MQSIperoxo4MQS-M2-Iperoxo
15.79Single4QIMANTA XV4QIM-SMO-ANTA XV
15.79Single4U14Tiotropium4U14-M3-Tiotropium
15.79Single5DSGTiotropium5DSG-M4-Tiotropium
15.79Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.79Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
15.79Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.79Single5UIGCmpd-15UIG-A2A-Cmpd-1
15.79Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
15.79Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
15.79Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
15.79Single6S0LZM-2413856S0L-A2A-ZM-241385
15.79Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
15.79Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.79Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.79Single7PYRPSB-21157PYR-A2A-PSB-2115
15.79Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.79Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
15.79Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
15.79Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.79Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
15.79Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
15.79Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
15.79Single8X63Mepyramine8X63-H1-Mepyramine
15.79Single8X64Desloratadine8X64-H1-Desloratadine
15.79Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.79Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
15.79Single9IYAONO-97105319IYA-GPR55-ONO-9710531
15.79Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.79Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.79Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.79Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
15.79Consensuscck_offOrthosteric Ligandccka_off
15.79Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
15.79Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.79Consensushistamine_offOrthosteric Ligandh1_off
15.79Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.79Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
15.79Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
15.62Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.38Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.38Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
15.38Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.38Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.00Single4JKVTaladegib4JKV-SMO-Taladegib
15.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
15.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
15.00Single5XPRBosentan5XPR-ETB-Bosentan
15.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
15.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
15.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
15.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
15.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
15.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
15.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
15.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
15.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
15.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
15.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
15.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
15.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
15.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.81Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.81Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.81Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
14.71Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.71Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
14.71Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.63Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.29Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
14.29Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
14.29Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.29Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
14.29Single5TZRMK86665TZR-FFA1-MK8666
14.29Single5V56TC1145V56-SMO-TC114
14.29Single5V57TC1145V57-SMO-TC114
14.29Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
14.29Single6E59L-7607356E59-NK1-L-760735
14.29Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
14.29Single7F1TMIP-1a7F1T-CCR5-MIP-1a
14.29Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
14.29Single7P2L4YI7P2L-mGlu5-4YI
14.29Single7R0CAVP7R0C-V2-AVP-Arrestin2
14.29Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.29Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
14.29Single7WC4Serotonin7WC4-5-HT2A-Serotonin
14.29Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
14.29Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
14.29Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
14.29Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
14.29Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
14.29Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
14.29Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
14.29Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.29Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.29Consensustachykinin_offOrthosteric Ligandnk1_off
13.64Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.64Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
13.64Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
13.64Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.64Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
13.64Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
13.64Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8XQJJN2418XQJ-Apelin-JN241
13.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
13.33Single3RFMCaffeine3RFM-A2A-Caffeine
13.33Single6TQ9SB-4081246TQ9-OX1-SB-408124
13.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.33Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
13.33Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.33Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
13.04Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.04Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
13.04Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
13.04Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
13.04Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
13.04Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8XVUCXCL28XVU-CXCR2-CXCL2
13.04Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
13.04Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
13.04Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
13.04Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.90Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.50Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
12.50Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
12.50Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single6KNMJN241-96KNM-Apelin-JN241-9
12.50Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
12.50Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.50Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.50Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.50Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
12.50Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
12.50Single8XQJJN2418XQJ-Apelin-JN241
12.50Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.50Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.50Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.50Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
12.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
12.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
12.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
11.76Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.76Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
11.76Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
11.76Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
11.76Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
11.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.76Single6HLLCP999946HLL-NK1-CP99994
11.76Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
11.76Single6LI0C176LI0-GPR52-C17
11.76Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.76Single6TP4ACT-4622066TP4-OX1-ACT-462206
11.76Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.76Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.76Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
11.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.76Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
11.76Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
11.76Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.76Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
11.76Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.54Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.54Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
11.11Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
11.11Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
11.11Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7F8ULintitript7F8U-CCKA-Lintitript
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
11.11Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
11.11Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.11Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
11.11Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
11.11Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.53Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.53Single3RZECidoxepin3RZE-H1-Cidoxepin
10.53Single5UVIZM-2413855UVI-A2A-ZM-241385
10.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.53Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.53Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
10.53Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.53Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
10.53Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.53Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
10.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
10.53Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.53Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
10.53Single9BJKNaloxone9BJK-μ-Naloxone-NAM
10.53Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
10.00Single6FFHFenobam6FFH-mGlu5-Fenobam
10.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
10.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
10.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.52Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.52Single6HLPNetupitant6HLP-NK1-Netupitant
9.52Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.52Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.52Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.52Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
9.52Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.52Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.52Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.09Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
9.09Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
9.09Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
9.09Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.09Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
9.09Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
9.09Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
9.09Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.70Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.70Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
8.70Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.70Single8XWACXCL18XWA-CXCR2-CXCL1
8.70Single8XWMCXCL68XWM-CXCR2-CXCL6
8.70Single8XWSCXCL58XWS-CXCR2-CXCL5
8.70Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.70Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.33Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
8.33Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.33Single8XWFCXCL38XWF-CXCR2-CXCL3
8.33Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
8.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
7.69Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
7.69Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.14Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.67Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.25Consensusp2y_offOrthosteric Ligandp2y1_off
5.88Single4XNWMRS25004XNW-P2Y1-MRS2500
5.88Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.88Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
5.88Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
5.88Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
5.88Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.88Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.56Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.56Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.56Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
5.56Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.56Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.56Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.56Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.56Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.26Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.26Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.26Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.26Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.26Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.26Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.26Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
5.00Single6ZINSR486926ZIN-NTS1-SR48692
5.00Single7VV6C48/807VV6-MRGPRX2-C48/80
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
4.76Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
4.76Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
4.76Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
4.76Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.76Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
4.55Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
4.55Single6Z4SSR486926Z4S-NTS1-SR48692
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.55Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
4.35Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
4.35Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
4.35Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
4.35Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
4.35Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.35Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.17Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.17Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.17Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.17Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
4.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
3.85Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
3.85Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
3.85Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
8J6R 8J6R-HCA2-MK6892-Gi1/β1/γ2
8JIM 8JIM-HCA2-MMF-Gi1/β1/γ2
8IHI 8IHI-HCA2-Acifran-Gi1/β1/γ2
8IHH 8IHH-HCA2-LUF6283-Gi1/β1/γ2
8I7V 8I7V-HCA2-Acipimox-Gi1/β1/γ2
8I7W 8I7W-HCA2-GSK256073-Gi1/β1/γ2
Net Summary
Imin 2.91167
Number of Linked Nodes 868
Number of Links 1051
Number of Hubs 162
Number of Links mediated by Hubs 640
Number of Communities 30
Number of Nodes involved in Communities 228
Number of Links involved in Communities 324
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 1970692
Length Of Smallest Path 3
Average Path Length 31.7726
Length of Longest Path 58
Minimum Path Strength 0.371667
Average Path Strength 5.53783
Maximum Path Strength 35.4233
Minimum Path Correlation 0.701667
Average Path Correlation 0.979698
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.08333
Average % Of Corr. Nodes 37.2017
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.9824
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_alicarboxylicgi_hca
gi_succinate



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