Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.05 6.93625419
2G.S1.06 4.028754188
3G.S1.07 5.1875419
4G.H1.01 2.613754189
5G.S2.03 5.466519
6G.S2.08 7.636555
7G.S3.03 5.23143757
8G.S3.04 6.51125416
9G.S3.06 8.839515
10G.S3.07 3.884189
11G.H2.06 6.345719
12G.H2.07 5.444519
13G.H2.09 5.39625418
14G.h2s4.01 7.573519
15G.h2s4.02 5.27417
16G.S4.02 5.502518
17G.S4.03 3.51625407
18G.S4.04 6.01833619
19G.s4h3.01 6.20254197
20G.s4h3.03 4.77418
21G.H3.17 7.6515
22G.H3.18 4.753519
23G.S5.02 4.76125406
24G.S5.04 5.008519
25G.S5.05 5.530717109
26G.S5.07 5.4409
27G.HG.05 5.15375405
28G.HG.07 6.6425409
29G.HG.08 3.0415196
30G.hgh4.02 5.9756207
31G.H4.10 10.66254206
32G.H4.15 6.90375418
33G.H4.16 3.68625413
34G.h4s6.11 5.5175407
35G.h4s6.12 7.79625454
36G.S6.01 3.92125415
37G.S6.02 6.523557
38G.H5.08 4.97333658
39G.H5.13 5.691558
40G.H5.17 5.602555
41G.H5.26 5.18875455
42b.lhb1x6 3.0735113
43b.b1x3 6.81875437
44b.l1x3 9.029539
45b.l1x6 12.5387419
46b.b2x1 5.71618
47b.b2x3 3.80625436
48b.b2x5 8.21083637
49b.l3x1 7.29625419
50b.l3x2 5.35125439
51b.b4x3 4.7415147
52b.b4x4 9.26625438
53b.b4x5 4.878754177
54b.b4x6 11.952539
55b.b5x2 5.6595167
56b.b5x3 7.32083639
57b.b5x5 5.2154175
58b.b5x7 5.8575407
59b.l5x1 5.2554148
60b.l5x5 7.42286719
61b.b6x3 2.60754148
62b.b6x5 5.84406
63b.b7x1 7.108754124
64b.b7x4 4.768754148
65b.b8x3 4.378754126
66b.b8x4 6.037506
67b.l8x3 3.73254253
68b.l8x5 4.201254253
69b.l9x3 7.011589
70b.l9x6 5.36188818
71b.b10x3 4.075488
72b.b10x5 6.3255129
73b.l10x1 4.86875403
74b.b11x4 5.9625489
75b.l11x2 6.385589
76b.b12x5 4.84125446
77b.b12x6 9.63688
78b.b12x7 5.50125449
79b.b13x7 7.791547
80b.l13x3 8.085649
81b.l13x6 7.4925419
82b.l13x7 4.393549
83b.b14x1 5.2225418
84b.b14x3 3.863545
85b.b15x1 7.3375449
86b.b15x2 8.0325416
87b.b15x3 3.8375449
88b.l15x1 5.42167617
89b.l15x2 6.282549
90b.b16x4 9.57546
91b.b16x5 5.4025405
92b.b16x6 8.27583648
93b.l16x3 4.00254153
94b.b17x7 7.88418
95b.l17x3 9.155619
96b.l17x6 8.114519
97b.b18x3 5.2825418
98b.b18x5 5.86505
99b.l18x1 8.735676
100b.l18x2 7.0675477
101b.l18x3 10.2275475
102b.b19x2 6.89833616
103b.b19x4 6.89625418
104b.l19x2 7.6575419
105b.b20x2 6.525416
106b.b20x4 9.556518
107b.b20x5 4.07625407
108b.b20x6 7.34616
109b.b21x1 8.0025417
110b.b21x2 4.5275406
111b.b21x7 5.9725605
112b.l21x5 3.612594
113b.l21x7 4.88495
114b.b22x5 4.94625877
115b.l22x5 6.1035119
116b.b23x2 5.93476
117b.b23x6 7.11143797
118b.b24x2 3.669595
119b.b24x3 3.7725465
120b.b24x4 6.61917696
121b.b24x5 4.645405
122b.b24x6 6.4925498
123b.b24x7 6.824119
124b.l24x2 5.043754116
125b.l24x3 5.40625405
126b.b25x3 5.62495
127b.b25x7 7.655467
128b.l25x3 7.638569
129b.b26x3 3.55917666
130b.l26x1 7.3437
131b.l26x5 4.5125635
132b.l27x1 11.2106819
133b.l27x2 5.589569
134b.b28x4 8.09875466
135b.b28x5 3.5475435
136b.b28x6 8.17667669
137g.h2x11 12.2213476
138g.ctx3 5.334176269
139g.ctx6 2.555406
140g.ctx14 4.77071739
141g.ctx15 7.66375439
142g.ctx16 4.88389938
143Lig 15.0182720
144NT 3.516526
1451x27 3.712525
1461x32 6.63375426
1471x43 4.828754137
1481x50 3.58125409
149I1x50 4.5725407
1502x39 5.0175238
1512x46 5.4275409
1522x50 6.3325409
1532x53 5.3825428
1542x54 3.654136
1552x56 8.50125426
1562x57 4.2115137
1572x60 5.7725427
1582x64 6.47125424
159E1x50 7.63429
160E1x52 4.09875427
1613x30 3.505406
1623x31 4.03125405
1633x33 7.059524
1643x50 6.866509
1653x51 5.87625408
166I2x52 4.375405
1674x41 5.57405
1684x56 4.3275425
1694x61 9.391525
170E2 24.96851023
1715x32 5.05375424
1725x35 9.365423
1735x39 7.78625427
1745x40 9.1425405
1755x42 7.81125424
1765x43 5.036526
1775x44 6.16625426
1785x46 7.6925425
1795x461 4.85526
1805x47 6.37375428
1815x50 4.37625409
1825x57 6.2925407
1835x58 7.16625409
1845x65 3.8465288
185I3 3.93167654
1866x26 5.73654
1876x29 5.53375455
1886x30 3.99125407
1896x48 5.30875828
1906x52 6.90625428
191E3 12.2183621
1927x23 7.155425
1937x35 7.318523
1947x49 3.35875409
1958x50 5.343754279
1968x54 3.72375407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 25.8922.975NoNo085
2b.b3x1 b.l2x3 25.5958.82NoNo058
3b.b3x1 b.b5x4 12.19392.98NoNo055
4G.S1.05 G.h2s4.01 29.746712.785YesYes199
5G.S1.05 G.S1.07 64.74416.92YesYes199
6G.S1.07 G.S4.04 1006.695YesYes199
7G.S4.04 G.s1h1.01 99.96153.01YesNo099
8G.H1.01 G.s1h1.01 99.77622.615YesNo099
9G.H1.01 G.S1.06 98.27482.82YesYes1898
10G.S1.06 G.S4.03 96.81144.28YesYes087
11G.H3.18 G.S1.05 35.53263.045YesYes199
12G.H3.15 G.H3.18 29.4873.02NoYes189
13G.H3.15 G.H3.17 29.59483.955NoYes185
14G.H3.17 b.l27x1 29.10484.685YesYes159
15b.b26x1 b.l27x1 15.98694.94NoYes099
16b.b26x1 b.b26x2 15.86353.44NoNo097
17b.b26x2 b.b2x3 15.74914.05NoYes076
18G.H1.04 G.S5.05 10.23535.025NoYes1079
19G.S4.03 G.S5.05 91.09133.14YesYes079
20b.l2x5 b.l4x2 23.690829.325NoNo054
21b.l26x5 g.ctx4 16.42795.87YesNo057
22g.ctx3 g.ctx4 19.0964.83YesNo097
23b.l22x2 g.ctx3 18.08173.46NoYes019
24b.l22x2 g.ctx2 18.03384.725NoNo013
25g.ctx2 g.h2x15 17.99083.695NoNo036
26g.h2x11 g.h2x15 18.890219.055YesNo066
27b.l18x1 g.h2x11 12.55815.67YesYes766
28b.b20x5 b.b22x5 13.87733.045YesYes077
29b.b20x5 b.b21x4 21.04833.46YesNo075
30b.b21x4 g.h2x1 20.08833.725NoNo058
31b.b21x2 g.h2x1 19.9315.73YesNo068
32b.1x18 b.b21x2 20.25013.505NoYes046
33b.1x14 b.1x18 64.04983.13NoNo044
34b.1x14 b.1x15 63.34454.805NoNo047
35b.1x12 b.1x15 62.99166.025NoNo067
36b.1x12 g.h1x11 61.57813.525NoNo069
37g.h1x11 g.h1x14 54.14412.65NoNo099
38b.b17x6 g.h1x14 53.78647.055NoNo079
39b.b16x4 b.b17x6 53.42869.76YesNo067
40b.b16x4 b.l13x3 13.772118.34YesYes469
41b.b14x3 b.b15x3 18.60413YesYes459
42b.b10x2 b.b14x3 26.90243.965NoYes065
43b.b10x2 b.b6x2 25.78363.38NoNo068
44b.b10x3 b.b6x2 24.66462.535YesNo088
45b.b10x3 b.b11x4 20.18284.225YesYes889
46b.b11x4 b.l9x3 13.45876.845YesYes899
47b.l11x2 b.l9x3 10.10233.78YesYes899
48b.l4x2 g.ctx16 16.55217.735NoYes348
49b.b16x4 b.b16x6 38.26399.86YesYes468
50b.b15x1 b.b16x6 10.03738.52YesYes498
51G.H2.07 G.h2s4.01 23.26625.51YesYes199
52G.H2.06 b.l9x6 25.53982.985YesYes198
53G.H2.05 G.H2.08 45.38052.91NoNo188
54G.H2.05 G.H2.06 44.92734.31NoYes189
55G.H2.06 b.l17x6 69.541810.37YesYes199
56G.S5.03 G.S5.05 81.4364.395NoYes089
57G.H5.10 G.S5.03 81.03523.25NoNo068
58G.H5.10 G.S6.02 80.83642.67NoYes067
59G.H5.13 G.S6.02 72.98647.47YesYes587
606x30 G.H5.13 71.78544.765YesYes078
613x50 G.H5.23 64.27695.57YesNo094
623x50 5x61 70.92883.1YesNo098
635x61 5x65 71.11123.61NoYes2888
645x65 6x30 71.98383.72YesYes087
652x39 G.H5.23 62.9695.65YesNo084
662x39 I1x52 59.29476.52YesNo2388
678x50 8x54 55.07473.755YesYes097
681x56 8x54 57.5353.77NoYes077
691x56 8x53 57.75846.545NoNo074
708x53 I1x50 57.98163.24NoYes047
712x40 I1x50 58.87266.31NoYes087
722x40 I1x52 59.094810.9NoNo088
73b.l17x5 b.l17x6 69.31364.415NoYes169
74b.l17x5 b.l19x2 69.35692.945NoYes169
75b.b19x6 b.l19x2 35.91185.15NoYes199
76b.b19x6 b.l17x3 35.790511.16NoYes199
77b.b20x6 b.l17x3 32.47114.53YesYes169
78b.b17x7 b.b20x6 54.748412.86YesYes186
79b.b17x7 b.b21x1 52.65074.18YesYes187
80b.b20x2 b.l19x2 33.248510.84YesYes169
81b.b20x2 b.b20x4 33.00136.465YesYes168
82b.b20x4 b.b20x6 32.4435.88YesYes186
83b.1x18 b.b21x1 53.19574.765NoYes047
84b.b13x7 b.b16x6 17.889416.54YesYes478
85b.b13x5 b.b13x7 17.34125.19NoYes447
86b.l4x1 g.ctx16 11.38585.28NoYes358
87b.b3x1 b.b6x5 13.10835.275NoYes056
88b.b3x3 b.b6x5 12.2065.05NoYes086
89b.b3x3 b.b4x3 11.90993.725NoYes087
90b.b13x4 b.b13x5 10.94265.495NoNo444
91b.b12x7 b.b13x4 10.60882.895YesNo494
92b.b19x2 b.b20x6 10.061210.72YesYes166
93b.l25x6 b.l27x1 13.805423.49NoYes089
94b.l23x1 b.l25x6 13.612219.06NoNo068
95b.l21x7 b.l23x1 13.52294.665YesNo056
96b.b23x6 b.l21x7 12.74873.36YesYes975
97b.b23x6 b.b24x6 11.377811.58YesYes978
98b.b21x7 b.b24x6 11.65935.305YesYes058
997x53 8x50 53.16616.7NoYes2799
1007x49 7x53 53.03793.43YesNo099
1012x46 7x49 48.99654.81YesYes099
1022x46 2x50 29.98466.11YesYes099
1032x50 7x46 29.6258.1YesNo099
1042x54 7x46 29.39013.095YesNo069
1052x54 2x57 26.40622.945YesYes1367
1061x39 2x57 26.08563.87NoYes077
1071x39 7x39 24.67126.705NoNo075
1081x35 7x39 23.963810.215NoNo055
1091x35 7x35 22.47285.23NoYes253
1107x35 Lig 21.74747.2YesYes230
1113x38 4x53 10.06195.415NoNo078
1123x38 4x50 10.516911.745NoNo079
1134x46 4x50 10.97613.525NoNo079
1142x45 4x46 18.18653.87NoNo097
1152x45 3x42 18.40853.26NoNo098
1162x46 3x42 18.63265.255YesNo098
117b.b2x5 b.l4x1 11.74966.795YesNo375
118b.b2x3 b.b2x5 14.96812.91YesYes367
119G.H3.18 G.S4.02 38.850410.045YesYes198
120G.S1.07 G.S4.02 35.65234.28YesYes198
121G.H2.07 b.l9x6 23.50184.34YesYes198
122G.H2.08 G.H3.18 45.25663.765NoYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
6x55Lig22.712NoYes6010
6x58Lig11.2550NoYes4010
E2Lig61.2152YesYes3010
E3Lig11.1252YesYes1010
6x62Lig6.022NoYes2010
7x23Lig8.7352YesYes5010
7x27Lig12.2352NoYes3010
1x25Lig8.9152NoYes4010
7x31Lig6.732NoYes3010
7x34Lig14.672NoYes4010
E2x51Lig3.9052NoYes4010
E1Lig5.2050NoYes4010
2x60Lig6.3752YesYes7010
6x51Lig21.362NoYes6010
7x35Lig7.22YesYes3010
7x38Lig2.9452NoYes6010
2x59Lig4.4152NoYes6010
2x63Lig4.362NoYes5010
E1x50Lig4.6952YesYes9010
3x32Lig9.8552NoYes6010
3x33Lig9.282YesYes4010
5x43Lig6.262YesYes6010
6x48Lig4.6852YesYes8010
6x52Lig5.292YesYes8010
NTNT2.922YesYes6622
7x23NT3.482YesYes5612
7x24NT7.282NoYes8622
1x257x244.912NoNo4812
1x257x283.0952NoNo4312
1x271x322.912YesYes5612
1x272x643.572YesYes5412
1x277x314.9952YesNo5311
1x322x644.232YesYes6422
1x352x643.432NoYes5422
1x357x355.232NoYes5321
2x532x5610.7152YesYes8622
2x533x364.1552YesNo8722
2x536x483.1752YesYes8821
2x562x605.3852YesYes6721
2x563x3213.7052YesNo6621
2x592x604.252NoYes6711
2x607x387.082YesNo7611
2x63E1x507.542NoYes5911
2x647x3514.6552YesYes4321
E1x49E26.6352NoYes5321
3x25E1x507.8352NoYes9921
E1x50E2x5010.452YesNo9912
3x22E23.1250NoYes3321
3x25E2x507.282NoNo9922
3x323x337.462NoYes6411
3x334x6112.152YesYes4512
3x335x432.822YesYes4611
3x335x4613.5852YesYes4612
3x365x4616.312NoYes7622
3x366x485.522NoYes7821
4x615x3910.82YesYes5722
E2E275.712YesYes3311
E2E2x517.1352YesNo3411
5x36E25.92NoYes4321
5x32E29.522YesYes4321
5x395x439.1652YesYes7621
5x406x557.740YesNo5621
5x425x433.422YesYes4621
5x435x4613.5152YesYes6612
5x445x478.5752YesYes6822
5x446x528.4852YesYes6821
5x476x529.6152YesYes8821
6x446x485.012NoYes9821
6x447x459.672NoNo9922
6x486x514.5552YesNo8611
6x486x524.2352YesYes8811
6x487x419.0752YesNo8812
6x487x456.2152YesNo8912
6x517x342.712NoNo6411
6x547x3410.310NoNo5421
6x627x238.232NoYes2511
6x627x273.5152NoNo2311
E3E325.6252YesYes1111
7x317x355.2752NoYes3311
1x27Lig2.8552YesYes5010
1x277x354.232YesYes5311
2x567x384.22YesNo6621
3x26E23.4550NoYes7321
7x23E38.1752YesYes5111
7x25E31.970NoYes4121
5x33E21.282NoYes1321
1x22E30.790NoYes4121

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
96.15Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
88.46Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
82.14Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
82.14Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
81.48Consensusendothelin_onOrthosteric Ligandetb_on eta_on
76.92Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
75.00Single6IGLIRL16206IGL-ETB-IRL1620
75.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
75.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
72.41Single5GLHEndothelin-15GLH-ETB-Endothelin-1
67.86Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
67.74Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
66.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
64.29Single8ZRTET-18ZRT-ETB-ET-1
60.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
56.67Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
55.17Single6JODAngiotensin II6JOD-AT2-Angiotensin II
55.17Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
54.84Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
54.84Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
53.57Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
53.33Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
53.33Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
53.33Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
51.72Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
50.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
48.39Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
48.28Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
47.06Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
46.88Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
46.67Single6PT2KGCHM076PT2-δ-KGCHM07
46.67Consensusangiotensin_onOrthosteric Ligandat1_on
46.67Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
45.45Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
45.45Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
45.45Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
45.16Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
45.16Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
45.16Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
45.16Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
45.16Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
45.16Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
45.16Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
45.16Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
45.16Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
44.83Single8WDTphotoNECA8WDT-A2A-photoNECA
44.44Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
44.44Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
44.44Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
44.44Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
44.12Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
44.12Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
44.12Consensusbradykinin_onOrthosteric Ligandbk2_on
44.12Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
44.12Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
43.75Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
43.75Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
43.75Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
43.75Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
43.33Single3QAKUK-4320973QAK-A2A-UK-432097
43.33Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
43.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
43.33Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
43.33Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
42.86Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
42.86Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
42.86Single7EZCUKA7EZC-A2A-UKA
42.86Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
42.86Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
42.42Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
42.42Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
42.42Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
42.42Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
42.42Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
41.94Single5WF5UK-4320975WF5-A2A-UK-432097
41.94Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.94Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
41.94Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
41.67Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
41.38Single5WF6UK-4320975WF6-A2A-UK-432097
41.38Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
41.38Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
41.38Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
40.74Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
40.74Single6OS1TRV0266OS1-AT1-TRV026
40.74Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
40.62Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
40.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.00Single7F8XNN90567F8X-CCKA-NN9056
40.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
40.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
40.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
40.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
40.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
40.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
40.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
40.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
40.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
40.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
39.39Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
39.39Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
39.39Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
39.39Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
39.39Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
39.39Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
39.39Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.29Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
39.29Single6MXTSalmeterol6MXT-β2-Salmeterol
39.29Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single8JJLOlodaterol8JJL-β2-Olodaterol
39.29Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
39.29Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
39.29Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
39.29Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
39.29Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
39.29Consensuslpa_offOrthosteric Ligandlpa1_off
39.29Consensuslpl_offOrthosteric Ligands1p_off lpa_off
39.29Consensusorexin_onOrthosteric Ligandox2_on
38.89Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.89Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.89Consensusbombesin_onOrthosteric Ligandbb2_on
38.89Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
38.89Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.71Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
38.71Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
38.71Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.71Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
38.71Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.71Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
38.71Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
38.24Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.24Single7SK3CXCL127SK3-ACKR3-CXCL12
37.93Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
37.93Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
37.93Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
37.93Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
37.93Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
37.93Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
37.93Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
37.50Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
37.50Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
37.50Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
37.50Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
37.50Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
37.50Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.50Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
37.50Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
37.50Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
37.50Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
37.50Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
37.50Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
37.14Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
37.04Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
37.04Single5IUAQ274563485IUA-A2A-Q27456348-Na
37.04Single5N2RPSB-365N2R-A2A-PSB-36-Na
37.04Single5N2SPSB365N2S-A1-PSB36
37.04Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
37.04Single6D26Fevipiprant6D26-DP2-Fevipiprant
37.04Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
37.04Single6S0QZM-2413856S0Q-A2A-ZM-241385
37.04Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
37.04Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
37.04Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
37.04Single8GNEKW-63568GNE-A2A-KW-6356-Na
37.04Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
37.04Consensusadenosine_offOrthosteric Liganda1_off a2_off
37.04Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
37.04Consensusdp_offOrthosteric Liganddp2_off
36.67Single4UG2CGS216804UG2-A2A-CGS21680
36.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
36.67Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
36.67Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
36.67Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
36.67Single8QJ2pN1628QJ2-MC4-pN162-Gs
36.67Single8X5YAstemizole8X5Y-H1-Astemizole
36.67Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
36.67Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
36.67Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
36.67Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.67Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
36.36Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
36.36Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
36.36Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
36.36Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.36Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.11Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
35.90Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
35.71Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
35.71Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
35.71Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
35.71Single7PX4PSB-21137PX4-A2A-PSB-2113
35.71Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
35.71Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
35.71Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
35.71Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
35.71Single8XVLZibotentan8XVL-ETA-Zibotentan
35.71Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
35.48Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
35.48Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.48Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
35.48Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
35.48Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
35.48Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
35.48Consensuslpl_onOrthosteric Ligands1p_on lpa_on
35.48Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
35.48Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.29Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
35.29Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
35.29Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
35.29Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
35.29Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
35.14Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
35.14Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.14Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
35.14Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
34.62Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
34.62Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
34.62Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
34.62Single7T32ZM-2413857T32-A2A-ZM-241385
34.48Single4RWADIPP-NH24RWA-δ-DIPP-NH2
34.48Single6A93Risperidone6A93-5-HT2A-Risperidone
34.48Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
34.48Single6OS2TRV0266OS2-AT1-TRV026
34.48Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
34.48Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
34.48Single7YITNalfurafine7YIT-κ-Nalfurafine
34.48Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
34.48Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
34.48Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
34.48Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
34.48Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
34.48Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
34.38Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
34.38Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.38Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
34.38Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
34.38Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
34.38Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.38Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
34.38Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
34.38Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
34.38Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
34.38Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.38Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.38Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.38Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.29Single4XT3Fractalkine4XT3-US28-Fractalkine
34.29Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
34.29Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
34.29Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.29Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
34.29Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
34.29Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
34.21Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
34.21Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
34.15Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
34.15Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Single3EMLZM-2413853EML-A2A-ZM-241385
33.33Single3OE0CVX153OE0-CXCR4-CVX15
33.33Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
33.33Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
33.33Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
33.33Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
33.33Single6IBLArformoterol6IBL-β1-Arformoterol
33.33Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
33.33Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
33.33Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
33.33Single6S0LZM-2413856S0L-A2A-ZM-241385
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
33.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
33.33Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
33.33Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
33.33Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Single8CU6LJ-45178CU6-A2A-LJ-4517
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
33.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
33.33Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
33.33Single9CHXS-Carazolol9CHX-β2-S-Carazolol
33.33Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
33.33Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
33.33Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
33.33Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
33.33Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
33.33Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
33.33Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
33.33Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
33.33Consensusprostanoid_offOrthosteric Ligandep_off dp_off
32.43Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
32.35Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
32.35Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.35Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
32.35Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
32.35Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
32.35Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
32.35Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
32.35Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
32.26Single3NY9ICI118-5513NY9-β2-ICI118-551
32.26Single6PT3DPI-2876PT3-δ-DPI-287
32.26Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
32.26Single7SK9CCX6627SK9-ACKR3-CCX662
32.26Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
32.26Single7XN9L-054,5227XN9-SST2-L-054,522
32.26Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
32.26Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
32.26Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
32.26Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
32.26Single8XQJJN2418XQJ-Apelin-JN241
32.26Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
32.26Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
32.26Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
32.26Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
32.26Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single5C1MBU725C1M-μ-BU72
32.14Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
32.14Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
32.14Single7C61Ergotamine7C61-5-HT1B-Ergotamine
32.14Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
32.14Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
32.14Single8QOTNanobody-E8QOT-μ-Nanobody-E
32.14Single8S4DCMF-0198S4D-Apelin-CMF-019
32.14Single8TF5Oleic acid8TF5-GPR6-Oleic acid
32.14Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
32.14Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
32.14Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
32.14Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
32.14Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
32.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
32.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
31.43Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
31.43Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.43Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
31.25Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
31.25Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
31.25Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
31.25Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
31.25Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
31.25Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
31.25Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Single8XWNCXCL88XWN-CXCR2-CXCL8
31.25Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
31.25Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
31.03Single2YDVNECA2YDV-A2A-NECA
31.03Single3P0GBI1671073P0G-β2-BI167107
31.03Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
31.03Single4UHRCGS216804UHR-A2A-CGS21680
31.03Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
31.03Single5G53NECA5G53-A2A-NECA-Gs
31.03Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
31.03Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
31.03Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
31.03Single7TUYGSK682753A7TUY-GPR183-GSK682753A
31.03Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
31.03Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
31.03Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
31.03Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
31.03Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
31.03Single8E0GBU728E0G-μ-BU72
31.03Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
31.03Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
31.03Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
31.03Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
31.03Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
31.03Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
31.03Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
31.03Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
31.03Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
31.03Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
31.03Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
31.03Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
31.03Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
31.03Consensuslpa_onOrthosteric Ligandlpa1_on
31.03Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
31.03Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
30.77Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
30.77Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
30.77Single7F8ULintitript7F8U-CCKA-Lintitript
30.77Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
30.77Single8GNGIstradefylline8GNG-A2A-Istradefylline
30.77Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
30.77Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
30.77Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
30.77Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
30.56Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
30.56Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
30.30Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
30.30Single7SK5CXCL127SK5-ACKR3-CXCL12
30.30Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
30.30Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.30Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
30.00Single4AMIBucindolol4AMI-β1-Bucindolol
30.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
30.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
30.00Single6CM4Risperidone6CM4-D2-Risperidone
30.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
30.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
30.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
30.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
30.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8JJ8Formoterol8JJ8-β2-Formoterol
30.00Single8JWY2-1188JWY-A2A-2-118
30.00Single8JWZAB9288JWZ-A2A-AB928-Na
30.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
30.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
30.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
30.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
30.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
30.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
30.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
30.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
30.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
30.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
30.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
30.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
30.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
30.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
30.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
30.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.79Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.73Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.73Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
29.63Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
29.63Single5IU7Q274563465IU7-A2A-Q27456346-Na
29.63Single5IUBQ274563445IUB-A2A-Q27456344-Na
29.63Single5JTBZM-2413855JTB-A2A-ZM-241385
29.63Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
29.63Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
29.63Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
29.63Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
29.63Single5UVIZM-2413855UVI-A2A-ZM-241385
29.63Single6AQFZM-2413856AQF-A2A-ZM-241385
29.63Single6IQLL7458706IQL-D4-L745870
29.63Single6MH8ZM-2413856MH8-A2A-ZM-241385
29.63Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
29.63Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
29.63Single7AROLUF58337ARO-A2A-LUF5833-Na
29.63Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
29.63Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
29.63Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
29.63Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.63Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
29.63Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
29.63Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
29.63Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
29.63Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
29.63Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
29.63Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
29.63Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
29.63Consensusa2_offOrthosteric Liganda2a_off
29.63Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
29.63Consensusalpha1_onOrthosteric Ligandalpha1a_on
29.63Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
29.63Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
29.63Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
29.63Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
29.41Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
29.41Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
29.41Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
29.41Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.41Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
29.41Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
29.41Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
29.41Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
29.03Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
29.03Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
29.03Single5X93K-87945X93-ETB-K-8794
29.03Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
29.03Single6H7LDobutamine6H7L-β1-Dobutamine
29.03Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
29.03Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
29.03Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.03Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
29.03Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.03Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
29.03Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
29.03Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
29.03Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
29.03Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
29.03Single8XVUCXCL28XVU-CXCR2-CXCL2
29.03Single8XWFCXCL38XWF-CXCR2-CXCL3
29.03Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
29.03Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
29.03Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
29.03Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
29.03Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
29.03Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
29.03Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.03Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
29.03Consensuschemerin_onOrthosteric Ligandcml1_on
29.03Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
29.03Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
29.03Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.95Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
28.95Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
28.57Single2Y02Carmoterol2Y02-β1-Carmoterol
28.57Single3NY8ICI118-5513NY8-β2-ICI118-551
28.57Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
28.57Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
28.57Single4EJ4Naltrindole4EJ4-δ-Naltrindole
28.57Single4GBRS-Carazolol4GBR-β2-S-Carazolol
28.57Single5DHHSB-6121115DHH-NOP-SB-612111
28.57Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
28.57Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
28.57Single5UIGCmpd-15UIG-A2A-Cmpd-1
28.57Single6D27CAY104716D27-DP2-CAY10471
28.57Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
28.57Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
28.57Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
28.57Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
28.57Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
28.57Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.57Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
28.57Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.57Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
28.57Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
28.57Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
28.57Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
28.57Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
28.57Single8JXRLSD8JXR-D1-LSD
28.57Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
28.57Single8T1WCVN4248T1W-GPR6-CVN424
28.57Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
28.57Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
28.57Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
28.57Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
28.57Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
28.57Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.57Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.57Consensuscck_offOrthosteric Ligandccka_off
28.57Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
28.57Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
28.57Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
28.57Consensusdopamine_offOrthosteric Ligandd2_off d3_off
28.57Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.57Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.57Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
28.57Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
28.57Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.57Consensusvasop-oxy_onOrthosteric Ligandv2_on
28.57Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
28.12Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
28.12Single5ZTYAM102575ZTY-CB2-AM10257
28.12Single6KNMJN241-96KNM-Apelin-JN241-9
28.12Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.12Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
28.12Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
28.12Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
28.12Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
28.12Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
28.12Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
28.12Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
28.12Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
28.12Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
28.00Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
27.78Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
27.78Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
27.78Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
27.78Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
27.78Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
27.78Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.78Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
27.59Single2RH1S-Carazolol2RH1-β2-S-Carazolol
27.59Single2Y00Dobutamine2Y00-β1-Dobutamine
27.59Single2YCWS-Carazolol2YCW-β1-S-Carazolol
27.59Single5D6LS-Carazolol5D6L-β2-S-Carazolol
27.59Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
27.59Single5XPRBosentan5XPR-ETB-Bosentan
27.59Single6E67BI1671076E67-β2-BI167107-Gs (fused)
27.59Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
27.59Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
27.59Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.59Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
27.59Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.59Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
27.59Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
27.59Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
27.59Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
27.59Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
27.59Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8JXSPF-61428JXS-D1-PF-6142
27.59Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.59Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
27.59Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
27.59Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
27.59Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
27.59Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
27.59Consensusamine_offonOrthosteric Ligandamine_off amine_on
27.59Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
27.59Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
27.59Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
27.59Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
27.59Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
27.59Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
27.59Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.59Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
27.59Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
27.59Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
27.59Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.59Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.59Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.59Consensustrace-amine_onOrthosteric Ligandta1_on
27.27Single4XT1Fractalkine4XT1-US28-Fractalkine
27.27Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
27.27Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
27.27Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
27.27Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
27.27Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
27.27Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
27.27Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
27.27Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
27.27Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
27.27Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
27.27Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
27.27Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
26.92Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.92Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
26.92Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
26.92Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
26.92Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
26.92Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
26.92Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.92Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.67Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
26.67Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
26.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
26.67Single5D5AS-Carazolol5D5A-β2-S-Carazolol
26.67Single5D5BS-Carazolol5D5B-β2-S-Carazolol
26.67Single6J21Aprepitant6J21-NK1-Aprepitant
26.67Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
26.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
26.67Single6WGTLSD6WGT-5-HT2A-LSD
26.67Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
26.67Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
26.67Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
26.67Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
26.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
26.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
26.67Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
26.67Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
26.67Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
26.67Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
26.67Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
26.67Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
26.67Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
26.67Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
26.67Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
26.67Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
26.67Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
26.67Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.67Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
26.67Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
26.67Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.67Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
26.67Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.67Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
26.67Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
26.67Consensusa2_onOrthosteric Liganda2b_on
26.67Consensusa2_on_gpOrthosteric Liganda2b_on_gp
26.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.67Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
26.67Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
26.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.67Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.67Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
26.67Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.67Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.67Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.67Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.67Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
26.67Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
26.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
26.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
26.67Consensusneurotensin_onOrthosteric Ligandnts1_on
26.67Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.67Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
26.67Consensusrelaxin_onOrthosteric Ligandrxfp4_on
26.67Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
26.67Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
26.47Single6HLOAprepitant6HLO-NK1-Aprepitant
26.47Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.47Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
26.47Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
26.47Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
26.32Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
25.93Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
25.93Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
25.93Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.93Single6AKXA4R6AKX-CCR5-A4R
25.93Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.93Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
25.93Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
25.93Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
25.93Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
25.93Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
25.93Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.93Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
25.93Single7XRRLemborexant7XRR-OX2-Lemborexant
25.93Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.93Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
25.93Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
25.93Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
25.93Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
25.93Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
25.93Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
25.93Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.93Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
25.93Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
25.81Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
25.81Single3D4STimolol3D4S-β2-Timolol
25.81Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
25.81Single4LDEBI1671074LDE-β2-BI167107
25.81Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.81Single4XESNeurotensin4XES-NTS1-Neurotensin
25.81Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.81Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
25.81Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
25.81Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.81Single6KQICP559406KQI-CB1-CP55940-Org27569
25.81Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
25.81Single6ZG4HTL00099366ZG4-M1-HTL0009936
25.81Single7DFPSpiperone7DFP-D2-Spiperone
25.81Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.81Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.81Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
25.81Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.81Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
25.81Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
25.81Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
25.81Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
25.81Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
25.81Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.81Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
25.81Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
25.81Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
25.81Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.81Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
25.81Single8XQJJN2418XQJ-Apelin-JN241
25.81Single8XWACXCL18XWA-CXCR2-CXCL1
25.81Single8XWMCXCL68XWM-CXCR2-CXCL6
25.81Single8XWSCXCL58XWS-CXCR2-CXCL5
25.81Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
25.81Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.81Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.81Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.81Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
25.81Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
25.81Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
25.81Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
25.81Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
25.81Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
25.81Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.81Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.71Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.71Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.71Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
25.71Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
25.64Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
25.00Single3REYXAC3REY-A2A-XAC
25.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
25.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
25.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
25.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
25.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
25.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
25.00Single6KUXRS-799486KUX-α2a-RS-79948
25.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
25.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
25.00Single6PS4ICI118-5516PS4-β2-ICI118-551
25.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
25.00Single6TPGEMPA6TPG-OX2-EMPA
25.00Single6TPNHTL66416TPN-OX2-HTL6641
25.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
25.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
25.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
25.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
25.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
25.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
25.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
25.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
25.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
25.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
25.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
25.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
25.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
25.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
25.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
25.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
25.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
25.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
25.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
25.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
25.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
25.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
25.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
25.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
25.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
25.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
25.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
25.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
25.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
25.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
25.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
25.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
25.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
25.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
25.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
25.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
25.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
25.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
25.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.00Consensusgrh_offOrthosteric Ligandgnrh1_off
24.32Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
24.32Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
24.32Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.32Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
24.24Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
24.24Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
24.24Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
24.24Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
24.24Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
24.24Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.24Consensuskisspeptin_onOrthosteric Ligandkiss1_on
24.14Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
24.14Single2Y01Dobutamine2Y01-β1-Dobutamine
24.14Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
24.14Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
24.14Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
24.14Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
24.14Single4QIMANTA XV4QIM-SMO-ANTA XV
24.14Single5DHGC-355DHG-NOP-C-35
24.14Single5UENDU1725UEN-A1-DU172
24.14Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
24.14Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
24.14Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
24.14Single6PS1Timolol6PS1-β2-Timolol
24.14Single6TOTLemborexant6TOT-OX1-Lemborexant
24.14Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
24.14Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
24.14Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
24.14Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
24.14Single7BU7BI1671077BU7-β1-BI167107
24.14Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.14Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
24.14Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
24.14Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
24.14Single7UL4Alvimopan7UL4-μ-Alvimopan
24.14Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
24.14Single7V3ZCP559407V3Z-CB1-CP55940
24.14Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
24.14Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
24.14Single7WC7Lisuride7WC7-5-HT2A-Lisuride
24.14Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
24.14Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
24.14Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
24.14Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
24.14Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
24.14Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
24.14Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
24.14Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
24.14Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
24.14Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
24.14Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
24.14Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
24.14Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
24.14Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
24.14Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
24.14Single8JJOAlprenolol8JJO-β2-Alprenolol
24.14Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
24.14Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
24.14Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
24.14Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
24.14Single8RLNLUF58348RLN-A2A-LUF5834
24.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
24.14Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
24.14Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
24.14Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
24.14Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
24.14Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
24.14Single8X63Mepyramine8X63-H1-Mepyramine
24.14Single8X64Desloratadine8X64-H1-Desloratadine
24.14Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
24.14Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
24.14Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.14Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
24.14Consensus5ht5_onOrthosteric Ligand5ht5a_on
24.14Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
24.14Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.14Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
24.14Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
24.14Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
24.14Consensusa3_onOrthosteric Liganda3a_on
24.14Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
24.14Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
24.14Consensusalpha2_onOrthosteric Ligandalpha2b_on
24.14Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
24.14Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
24.14Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
24.14Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
24.14Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
24.14Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
24.14Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
24.14Consensushistamine_offOrthosteric Ligandh1_off
24.14Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
23.68Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
23.68Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
23.53Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.53Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
23.53Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
23.53Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8WKYPG-9348WKY-MC4-PG-934
23.53Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
23.53Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
23.53Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
23.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
23.33Single5JQHS-Carazolol5JQH-β2-S-Carazolol
23.33Single5TVNLSD5TVN-5-HT2B-LSD
23.33Single5WIUNemonapride5WIU-D4-Nemonapride
23.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.33Single5WQCEMPA5WQC-OX2-EMPA
23.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
23.33Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
23.33Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
23.33Single6HLPNetupitant6HLP-NK1-Netupitant
23.33Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
23.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
23.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
23.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
23.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
23.33Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
23.33Single6PS6Timolol6PS6-β2-Timolol
23.33Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
23.33Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
23.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
23.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
23.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
23.33Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
23.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
23.33Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
23.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
23.33Single7W41PD1762527W41-BB2-PD176252
23.33Single7WC6LSD7WC6-5-HT2A-LSD
23.33Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
23.33Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
23.33Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
23.33Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
23.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
23.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
23.33Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
23.33Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
23.33Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
23.33Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
23.33Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
23.33Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
23.33Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
23.33Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.33Consensusa3_on_gpOrthosteric Liganda3a_on_gp
23.33Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.33Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.33Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
23.33Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
23.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
23.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
23.33Consensusbombesin_offOrthosteric Ligandbb2_off
23.33Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.33Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
23.33Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
23.33Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.33Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
23.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
23.08Single3OE6IT1t3OE6-CXCR4-IT1t
23.08Single4XNWMRS25004XNW-P2Y1-MRS2500
23.08Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.08Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
23.08Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.08Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.08Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
23.08Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.08Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
22.86Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
22.86Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
22.86Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
22.86Single7XNACYN1548067XNA-SST2-CYN154806
22.86Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
22.86Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
22.86Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.86Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
22.86Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
22.58Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
22.58Single4BV0Neurotensin4BV0-NTS1-Neurotensin
22.58Single4DJHJDTic4DJH-κ-JDTic
22.58Single4U15Tiotropium4U15-M3-Tiotropium
22.58Single5V56TC1145V56-SMO-TC114
22.58Single5XRAAM115425XRA-CB1-AM11542
22.58Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
22.58Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
22.58Single6H7JIsoprenaline6H7J-β1-Isoprenaline
22.58Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
22.58Single6OL9Tiotropium6OL9-M5-Tiotropium
22.58Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.58Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
22.58Single7B6WCyclazosin7B6W-α1b-Cyclazosin
22.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.58Single7F1TMIP-1a7F1T-CCR5-MIP-1a
22.58Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
22.58Single7R0CAVP7R0C-V2-AVP-Arrestin2
22.58Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
22.58Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
22.58Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
22.58Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
22.58Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
22.58Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
22.58Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
22.58Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
22.58Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
22.58Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.58Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
22.58Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
22.58Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
22.58Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
22.58Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
22.58Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
22.58Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
22.58Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
22.58Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
22.58Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
22.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.58Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.58Consensustachykinin_offOrthosteric Ligandnk1_off
22.50Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
22.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.50Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
22.22Single3OE9IT1t3OE9-CXCR4-IT1t
22.22Single3PBLEticlopride3PBL-D3-Eticlopride
22.22Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
22.22Single4O9RCyclopamine4O9R-SMO-Cyclopamine
22.22Single5L7IVismodegib5L7I-SMO-Vismodegib
22.22Single6W25SHU91196W25-MC4-SHU9119-Ca
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
22.22Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
22.22Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
22.22Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.22Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
22.22Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
22.22Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
22.22Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
22.22Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
22.22Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
21.88Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
21.88Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
21.88Single5CXVTiotropium5CXV-M1-Tiotropium
21.88Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.88Single6YVRNTS8-136YVR-NTS1-NTS8-13
21.88Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
21.88Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
21.88Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
21.88Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
21.88Single7K15MKD0467K15-BLT1-MKD046-Na
21.88Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.88Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
21.88Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
21.88Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.88Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
21.88Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
21.88Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
21.88Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.88Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
21.88Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
21.88Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
21.88Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
21.88Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.88Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
21.88Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.88Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.62Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
21.62Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
21.62Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.62Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.43Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
21.43Single3ODUIT1t3ODU-CXCR4-IT1t
21.43Single3PWHZM-2413853PWH-A2A-ZM-241385
21.43Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
21.43Single4BWBNeurotensin4BWB-NTS1-Neurotensin
21.43Single4QINSAG1.54QIN-SMO-SAG1.5
21.43Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.43Single5WS3EMPA5WS3-OX2-EMPA
21.43Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.43Single6B73MP11046B73-κ-MP1104
21.43Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
21.43Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
21.43Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
21.43Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.43Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.43Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
21.43Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
21.43Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
21.43Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.43Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.43Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
21.43Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
21.43Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
21.43Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
21.43Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
21.43Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
21.43Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.43Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
21.43Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
21.43Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
21.43Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
21.43Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
21.43Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
21.43Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
21.43Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
21.43Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
21.43Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
21.43Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.43Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
21.43Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
21.43Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.43Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
21.43Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
21.43Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
21.43Consensusalpha2_offOrthosteric Ligandalpha2c_off
21.43Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.43Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
21.43Consensusorexin_offOrthosteric Ligandox2_off ox1_off
21.43Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
21.43Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
21.43Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
21.21Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
21.21Single6K1QIRL25006K1Q-ETB-IRL2500
21.21Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
21.21Single7UM4AS26747237UM4-5-HT5A-AS2674723
21.21Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
21.21Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
21.21Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
21.21Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
21.21Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
21.05Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
21.05Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
20.69Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.69Single2YDOAdenosine2YDO-A2A-Adenosine
20.69Single3RZECidoxepin3RZE-H1-Cidoxepin
20.69Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.69Single4ZJCSB-6740424ZJC-OX1-SB-674042
20.69Single6A94Zotepine6A94-5-HT2A-Zotepine
20.69Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
20.69Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
20.69Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
20.69Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.69Single6V9SGTPL114036V9S-OX1-GTPL11403
20.69Single6VI4JDTic6VI4-κ-JDTic
20.69Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
20.69Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.69Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.69Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
20.69Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
20.69Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
20.69Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
20.69Single7UL3Famotidine7UL3-H2-Famotidine
20.69Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.69Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
20.69Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.69Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.69Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
20.69Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.69Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
20.69Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
20.69Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
20.69Single8IHKAcifran8IHK-HCA3-Acifran
20.69Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
20.69Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.69Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
20.69Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.69Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
20.69Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
20.69Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.69Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
20.69Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
20.69Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.69Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
20.69Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.69Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
20.69Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.69Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
20.69Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
20.69Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
20.69Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.69Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.69Consensusopsins_offOrthosteric Ligandrhodopsin_off
20.69Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.69Consensussensory_offOrthosteric Ligandopsins_off
20.59Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.59Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
20.59Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
20.59Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
20.59Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.51Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.51Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
20.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
20.00Single2Y04Salbutamol2Y04-β1-Salbutamol
20.00Single4DAJTiotropium4DAJ-M3-Tiotropium
20.00Single4MQSIperoxo4MQS-M2-Iperoxo
20.00Single4QKX35V4QKX-β2-35V
20.00Single4U14Tiotropium4U14-M3-Tiotropium
20.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
20.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
20.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
20.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
20.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
20.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
20.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6H7MSalbutamol6H7M-β1-Salbutamol
20.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
20.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
20.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
20.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
20.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
20.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
20.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
20.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
20.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
20.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
20.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
20.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
20.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
20.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
20.00Single8K5DGSK2560738K5D-HCA2-GSK256073
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
20.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
20.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
20.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
20.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
20.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
20.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusblt_onOrthosteric Ligandblt1_on
20.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
20.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
20.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
20.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
20.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
20.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
20.00Consensusleukotriene_onOrthosteric Ligandblt_on
20.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
20.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Consensussomatostatin_offOrthosteric Ligandsst2_off
19.51Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
19.51Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
19.44Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.35Single2Y03Isoprenaline2Y03-β1-Isoprenaline
19.35Single4JKVTaladegib4JKV-SMO-Taladegib
19.35Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.35Single6LUQHaloperidol6LUQ-D2-Haloperidol
19.35Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
19.35Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
19.35Single6TP6Filorexant6TP6-OX1-Filorexant
19.35Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
19.35Single7C4SS1P7C4S-S1P3-S1P
19.35Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
19.35Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
19.35Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
19.35Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.35Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
19.35Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
19.35Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
19.35Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.35Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
19.35Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.35Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
19.35Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
19.35Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
19.35Single8ZMFA1L108ZMF-5-HT2C-A1L10
19.35Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
19.35Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
19.35Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
19.35Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.35Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
19.35Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
19.35Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single3OE8IT1t3OE8-CXCR4-IT1t
19.23Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
19.23Single6TQ9SB-4081246TQ9-OX1-SB-408124
19.23Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
19.23Single8A2OTheophylline8A2O-A2A-Theophylline-Na
19.23Single9CHUNoradrenaline9CHU-β2-Noradrenaline
19.23Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
19.23Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
19.23Consensusp2y_offOrthosteric Ligandp2y1_off
19.15Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
19.05Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.92Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.75Single5V54Methiothepin5V54-5-HT1B-Methiothepin
18.75Single5V57TC1145V57-SMO-TC114
18.75Single5XR8AM8415XR8-CB1-AM841
18.75Single6E59L-7607356E59-NK1-L-760735
18.75Single6J20Aprepitant6J20-NK1-Aprepitant
18.75Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
18.75Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
18.75Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
18.75Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
18.75Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
18.75Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8EA0Iperoxo8EA0-M3-Iperoxo
18.75Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
18.75Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
18.75Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
18.75Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.75Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.75Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
18.75Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.75Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.75Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
18.75Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
18.75Consensus5ht1_offOrthosteric Ligand5ht1b_off
18.75Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
18.75Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
18.75Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
18.75Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.75Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.75Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
18.60Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
18.60Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.52Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
18.52Single6ME5Agomelatine6ME5-MT1-Agomelatine
18.52Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
18.52Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
18.52Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
18.52Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
18.52Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.52Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
18.52Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
18.52Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
18.52Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensus5ht2_onOrthosteric Ligand5ht2b_on
18.52Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.52Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.42Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
18.42Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
18.42Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
18.42Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
18.42Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.42Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.42Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
18.18Single4N4WSANT-14N4W-SMO-SANT-1
18.18Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.18Single4PY02MeSATP4PY0-P2Y12-2MeSATP
18.18Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
18.18Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
18.18Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.18Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
18.18Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
18.18Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
18.18Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
18.18Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.18Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.95Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.95Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
17.95Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.95Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.95Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.86Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
17.86Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
17.86Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
17.86Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
17.86Single6HLLCP999946HLL-NK1-CP99994
17.86Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
17.86Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
17.86Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
17.86Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.86Single6TP4ACT-4622066TP4-OX1-ACT-462206
17.86Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
17.86Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.86Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
17.86Single7SRQLSD7SRQ-5-HT2B-LSD
17.86Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
17.86Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
17.86Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
17.86Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
17.86Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.86Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
17.86Consensusgq_nucleotideOrthosteric Ligandgq_p2y
17.86Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.78Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
17.78Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
17.78Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
17.65Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
17.65Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
17.65Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
17.65Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
17.65Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
17.65Single8XVJMacitentan8XVJ-ETA-Macitentan
17.65Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
17.50Single6FJ3PTH6FJ3-PTH1-PTH
17.50Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
17.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
17.50Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
17.39Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
17.24Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
17.24Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
17.24Single4S0VSuvorexant4S0V-OX2-Suvorexant
17.24Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.24Single6ME2Ramelteon6ME2-MT1-Ramelteon
17.24Single6ME9Ramelteon6ME9-MT2-Ramelteon
17.24Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
17.24Single6TODEMPA6TOD-OX1-EMPA-Na
17.24Single6TPJSuvorexant6TPJ-OX2-Suvorexant
17.24Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
17.24Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
17.24Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
17.24Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
17.24Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
17.24Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.24Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.24Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
17.24Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.24Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
17.24Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
17.24Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
17.24Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
17.24Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
17.24Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
17.24Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
17.24Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
17.24Single8Y0HVUF114188Y0H-CXCR3-VUF11418
17.24Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
17.24Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
17.24Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
17.24Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
17.24Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
17.24Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.24Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.24Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
17.24Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
17.24Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.24Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
17.24Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.24Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
17.24Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
17.24Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
17.24Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
17.24Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
17.14Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.14Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.14Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
17.07Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.07Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.07Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.07Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
17.07Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
17.07Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
17.07Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
16.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
16.67Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.67Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.67Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
16.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
16.67Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
16.67Single6ZINSR486926ZIN-NTS1-SR48692
16.67Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
16.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7QA8Peptide7QA8-STE2-Peptide
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
16.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
16.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
16.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
16.67Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
16.67Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
16.67Single8IEBA1LYA8IEB-GPR156-A1LYA
16.67Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
16.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
16.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
16.67Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8K5CAcipimox8K5C-HCA2-Acipimox
16.67Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
16.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
16.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.67Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
16.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensushca_onOrthosteric Ligandhca2_on
16.28Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
16.22Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.22Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
16.22Single8IEBA1LYA8IEB-GPR156-A1LYA
16.13Single5DSGTiotropium5DSG-M4-Tiotropium
16.13Single5T04Neurotensin5T04-NTS1-Neurotensin
16.13Single5TGZAM65385TGZ-CB1-AM6538
16.13Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
16.13Single6GPSMK08126GPS-CCR2-MK0812
16.13Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single7F83PF-051904577F83-Ghrelin-PF-05190457
16.13Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
16.13Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
16.13Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
16.13Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
16.13Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
16.13Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.13Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
16.13Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
16.13Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
16.13Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
16.13Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
16.13Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
16.13Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
16.13Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
16.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
15.91Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.91Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.91Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
15.91Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
15.79Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
15.62Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.62Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.62Single6GPXMK08126GPX-CCR2-MK0812
15.62Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
15.62Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.62Single6Z4SSR486926Z4S-NTS1-SR48692
15.62Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
15.62Single7SINNPS-21437SIN-CaS-NPS-2143
15.62Single7SINNPS-21437SIN-CaS-NPS-2143
15.62Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.62Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
15.62Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
15.62Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
15.62Consensusblt_offOrthosteric Ligandblt1_off
15.62Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
15.62Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.62Consensusep_offOrthosteric Ligandep4_off
15.62Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.62Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.62Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
15.56Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.56Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
15.56Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
15.56Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
15.56Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
15.38Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
15.38Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
15.38Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.38Single7WC4Serotonin7WC4-5-HT2A-Serotonin
15.38Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
15.38Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
15.38Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
15.38Single8PWNTheophylline8PWN-A2A-Theophylline
15.38Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
15.22Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
15.22Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
15.15Single5TZRMK86665TZR-FFA1-MK8666
15.15Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.15Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.15Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.15Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.15Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
15.15Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
15.15Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
15.15Single9BJKNAM9BJK-μ-Naloxone-NAM
15.15Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.15Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
15.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
14.81Single3RFMCaffeine3RFM-A2A-Caffeine
14.81Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.81Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
14.81Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
14.81Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
14.81Consensussensory_onOrthosteric Ligandopsins_on
14.71Single5X33BIIL2605X33-BLT1-BIIL260
14.71Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.71Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
14.71Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
14.71Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.71Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.71Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.71Single8XYIVUF106618XYI-CXCR3-VUF10661
14.71Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.71Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.71Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
14.63Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
14.63Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
14.29Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
14.29Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
14.29Single3UZAGTPL92363UZA-A2A-GTPL9236
14.29Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
14.29Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
14.29Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
14.29Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
14.29Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
14.29Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
14.29Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
14.29Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
14.29Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
14.29Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
14.29Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
14.29Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
14.29Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.29Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
14.29Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
14.29Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
14.29Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
14.29Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
14.29Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
14.29Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
14.29Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
14.29Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
14.29Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
14.00Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.95Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
13.95Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.95Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
13.89Single5EE7MK08935EE7-Glucagon-MK0893
13.89Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
13.89Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
13.89Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
13.89Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.89Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.79Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
13.79Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.79Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
13.79Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.79Single7UL2SR486927UL2-NTS1-SR48692-Na
13.79Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
13.79Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
13.79Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
13.79Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
13.79Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
13.79Single8K5BNiacin8K5B-HCA2-Niacin
13.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.79Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.79Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
13.79Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
13.79Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
13.79Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.79Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
13.79Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
13.79Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
13.79Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
13.79Single9B9Y7DY9B9Y-CB1-7DY
13.79Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
13.79Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
13.79Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
13.79Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.79Consensusneurotensin_offOrthosteric Ligandnts1_off
13.79Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
13.73Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
13.64Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
13.51Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
13.51Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.51Single8IEIA1LYA8IEI-GPR156-A1LYA
13.51Single8IEPA1LYA8IEP-GPR156-A1LYA
13.51Single8IEPA1LYA8IEP-GPR156-A1LYA
13.51Single8KIGSHU91198KIG-MC3-SHU9119-Ca
13.33Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
13.33Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
13.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
13.33Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
13.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
13.33Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
13.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
13.33Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
13.33Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
13.33Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
13.33Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
13.33Single8IWESpermidine8IWE-TA9-Spermidine
13.33Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
13.33Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
13.33Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.33Single9BA0A1AKN9BA0-CB1-A1AKN
13.33Consensusangiotensin_offOrthosteric Ligandat1_off
13.33Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.33Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.33Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.33Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.33Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
13.04Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
12.90Single6TPKRetosiban6TPK-OT-Retosiban
12.90Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
12.90Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8K2WAMG4878K2W-CXCR3-AMG487
12.90Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
12.90Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
12.90Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
12.90Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
12.90Consensusvasop-oxy_offOrthosteric Ligandot_off
12.82Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
12.82Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.82Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.77Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
12.50Single4YAYZD-71554YAY-AT1-ZD-7155
12.50Single6IIVDaltroban6IIV-TP-Daltroban
12.50Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
12.50Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
12.50Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
12.50Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
12.50Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
12.50Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.50Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.50Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
12.50Single9B9ZA1AKO9B9Z-CB1-A1AKO
12.50Single9IYAONO-97105319IYA-GPR55-ONO-9710531
12.50Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
12.50Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
12.20Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.20Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
12.12Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
12.12Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
12.12Single5CGCHTL142425CGC-mGlu5-HTL14242
12.12Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
12.12Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
12.12Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
12.12Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
12.12Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
12.12Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.12Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.12Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
11.90Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.90Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
11.76Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
11.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
11.76Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
11.76Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.63Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
11.54Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
11.54Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
11.54Single5MZPCaffeine5MZP-A2A-Caffeine-Na
11.54Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single6IIURamatroban6IIU-TP-Ramatroban
11.43Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
11.43Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.36Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
11.36Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
11.11Single5CGDHTL142425CGD-mGlu5-HTL14242
11.11Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
11.11Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
11.11Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
11.11Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.11Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
11.11Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
11.11Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.87Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.81Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
10.81Single8IEIA1LYA8IEI-GPR156-A1LYA
10.81Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
10.71Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.71Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
10.71Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
10.53Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
10.53Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
10.53Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
10.42Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
10.34Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.34Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.34Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.34Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
10.34Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.34Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.34Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.34Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.34Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.26Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
10.26Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
10.26Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
10.00Single6LI0C176LI0-GPR52-C17
10.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.76Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
9.68Single5U09Taranabant5U09-CB1-Taranabant
9.68Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.68Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.68Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.68Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.68Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.68Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.52Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
9.38Single7VV6C48/807VV6-MRGPRX2-C48/80
9.09Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.09Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
8.82Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.82Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.82Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.82Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.82Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.82Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.57Single7P2L4YI7P2L-mGlu5-4YI
8.57Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.57Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
8.33Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.11Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.89Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.41Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
7.14Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.90Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.90Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.90Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
6.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.67Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.67Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
6.45Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.45Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.45Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
6.45Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.45Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.45Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.45Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single6FFIMMPEP6FFI-mGlu5-MMPEP
6.06Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.88Single6FFHFenobam6FFH-mGlu5-Fenobam
5.88Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
5.71Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.71Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.56Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
5.56Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.70Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.57Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
3.45Single8HS2Fab0468HS2-GPR20-Fab046
3.45Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
3.33Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
3.23Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.23Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
3.03Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.03Single4XNVBPTU4XNV-P2Y1-BPTU
3.03Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
2.94Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
2.94Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94Single8IYXYL-3658IYX-GPR34-YL-365
2.94Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
2.86Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.86Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.78Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.70Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
2.70Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
2.63Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.38Single7SHEPI; PE7SHE-GPR158-PI; PE

Consensus Members
Id Members
8IY5 8IY5-ETB-Endothelin-1-Gi1/β1/γ2
8HBD 8HBD-ETB-IRL1620-Gi1/β1/γ2
Net Summary
Imin 2.665
Number of Linked Nodes 881
Number of Links 1124
Number of Hubs 196
Number of Links mediated by Hubs 719
Number of Communities 28
Number of Nodes involved in Communities 295
Number of Links involved in Communities 453
Path Summary
Number Of Nodes in MetaPath 123
Number Of Links MetaPath 122
Number of Shortest Paths 1681671
Length Of Smallest Path 3
Average Path Length 37.9002
Length of Longest Path 82
Minimum Path Strength 0.625
Average Path Strength 5.69079
Maximum Path Strength 41.9625
Minimum Path Correlation 0.7
Average Path Correlation 0.979258
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.51515
Average % Of Corr. Nodes 37.4907
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.5982
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_peptidegi_cck
gi_apelin
gi_compl-pept
gi_endothelin
gi_formylpeptide
gi_galanin
gi_ghrelin
gi_npy
gi_neurotensin
gi_opioid
gi_orexin
gi_relaxin
gi_somatostatin



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gi_endothelin.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.