Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:K46 9.5575424
2R:R:Q50 11.7725424
3R:R:Y53 4.175405
4R:R:L54 6.1975406
5R:R:Y58 7.4275407
6R:R:F66 7.9575415
7R:R:F76 7.9475406
8R:R:Y89 7.554507
9R:R:D97 6.42539
10R:R:F98 6.315417
11R:R:Y100 7.676537
12R:R:W117 7.94714718
13R:R:F119 9.02417
14R:R:Q127 8.485414
15R:R:F129 7.2175406
16R:R:N134 6.535438
17R:R:Y136 9.6477
18R:R:F141 9.575447
19R:R:H148 4.9175408
20R:R:R149 5.645409
21R:R:Y150 4.75833697
22R:R:Y189 9.234504
23R:R:R195 8.6425461
24R:R:Y214 8.68404
25R:R:Y217 9.4675405
26R:R:F226 11.1975408
27R:R:Y237 9.25833689
28R:R:H277 14478
29R:R:M295 5.8875404
30R:R:Y303 10.346524
31R:R:R310 11.3225425
32R:R:S317 5.7225439
33R:R:Y324 6.086509
34R:R:F331 9.53408
35W:W:?1 10.3289910
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F290 R:R:M295 14.7849.95NoYes034
2R:R:F290 R:R:R285 15.531410.69NoNo034
3R:R:D289 R:R:R285 16.27577.15NoNo014
4R:R:D289 R:R:R212 17.01548.34NoNo011
5R:R:L288 R:R:R212 17.753515.79NoNo031
6R:R:L211 R:R:L288 18.48868.3NoNo043
7R:R:L211 R:R:R287 19.220510.93NoNo045
8R:R:R287 R:R:T205 19.87996.47NoNo055
9R:R:T205 R:R:Y214 20.60726.24NoYes054
10R:R:Y189 R:R:Y214 25.5314.89YesYes044
11R:R:Y189 R:R:Y217 30.3688.94YesYes045
12R:R:I186 R:R:Y217 32.99627.25NoYes045
13R:R:H132 R:R:I186 33.666413.26NoNo054
14R:R:F131 R:R:H132 53.947710.18NoNo075
15R:R:F131 R:R:Y100 55.62478.25NoYes077
16R:R:L104 R:R:Y100 44.70588.21NoYes077
17R:R:L104 R:R:Y58 44.27964.69NoYes077
18R:R:L54 R:R:Y58 38.386910.55YesYes067
19R:R:L54 R:R:R310 24.81824.86YesYes065
20R:R:Q307 R:R:R310 18.71719.35NoYes255
21R:R:S314 R:R:Y100 45.85625.09NoYes077
22R:R:S314 R:R:Y58 44.57765.09NoYes077
23R:R:L107 R:R:Y58 52.16579.38NoYes077
24R:R:L107 R:R:Q127 51.078611.98NoYes074
25R:R:Q127 W:W:?1 20.90525.79YesYes140
26R:R:S317 R:R:Y100 52.9446.36YesYes397
27R:R:D97 R:R:N134 50.84246.73YesYes398
28R:R:N134 R:R:Y100 51.40610.47YesYes387
29R:R:D97 R:R:S317 51.87858.83YesYes399
30R:R:D97 R:R:N320 1006.73YesNo099
31R:R:L93 R:R:N320 99.4079.61NoNo099
32R:R:L93 R:R:Y324 98.20110.55NoYes099
33R:R:F76 R:R:Y324 43.21727.22YesYes069
34R:R:F76 R:R:S87 32.69045.28YesNo067
35R:R:S84 R:R:S87 31.7136.52NoNo077
36R:R:D329 R:R:S84 30.95797.36NoNo057
37R:R:M90 R:R:Y324 55.5835.99NoYes089
38R:R:I145 R:R:M90 54.12844.37NoNo088
39R:R:I145 R:R:Y89 30.68764.84NoYes087
40R:R:H148 R:R:Y89 20.84344.36YesYes087
41R:R:D329 R:R:I86 15.40029.8NoNo057
42R:R:H148 R:R:I86 16.19235.3YesNo087
43R:R:I86 R:R:R149 29.12956.26NoYes079
44R:R:D329 R:R:K257 14.96165.53NoNo058
45R:R:K257 R:R:R149 14.21896.19NoYes089
46R:R:I233 R:R:T143 10.10527.6NoNo088
47R:R:I233 R:R:Y237 10.98697.25NoYes889
48R:R:L261 R:R:Y237 18.77118.21NoYes079
49R:R:I145 R:R:L261 26.37634.28NoNo087
50R:R:Q127 R:R:W117 25.27377.67YesYes148
51R:R:H132 R:R:I183 24.26073.98NoNo057
52R:R:I183 R:R:Y136 19.22364.84NoYes077
53R:R:H277 R:R:Y136 14.00738.71YesYes787
54R:R:F226 R:R:H277 12.524933.94YesYes088
55R:R:F226 R:R:F269 10.23644.29YesNo089
56R:R:L254 R:R:R149 10.2384.86NoYes049
57R:R:R149 R:R:S258 30.65835.27YesNo097
58R:R:I240 R:R:S258 20.48523.1NoNo077
59R:R:I240 R:R:Y150 17.93732.42NoYes077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F62 R:R:F66 5.36 1 No Yes 6 5 1 1
R:R:F62 R:R:P105 13 1 No No 6 9 1 1
R:R:F62 W:W:?1 12.87 1 No Yes 6 0 1 0
R:R:F66 R:R:S70 7.93 1 Yes No 5 3 1 2
R:R:F66 R:R:F98 6.43 1 Yes Yes 5 7 1 2
R:R:F66 W:W:?1 12.11 1 Yes Yes 5 0 1 0
R:R:F98 R:R:S70 5.28 1 Yes No 7 3 2 2
R:R:F98 R:R:L102 8.53 1 Yes No 7 5 2 1
R:R:L102 W:W:?1 5.16 0 No Yes 5 0 1 0
R:R:Q127 R:R:T103 8.5 1 Yes No 4 6 1 1
R:R:I130 R:R:T103 4.56 0 No No 4 6 2 1
R:R:T103 W:W:?1 13.74 1 No Yes 6 0 1 0
R:R:P105 W:W:?1 17.35 1 No Yes 9 0 1 0
R:R:A106 W:W:?1 7.83 0 No Yes 6 0 1 0
R:R:L107 R:R:Q127 11.98 0 No Yes 7 4 2 1
R:R:F109 R:R:I118 7.54 1 No No 3 3 2 2
R:R:F109 R:R:F119 6.43 1 No Yes 3 7 2 1
R:R:F119 R:R:W117 12.03 1 Yes Yes 7 8 1 2
R:R:Q127 R:R:W117 7.67 1 Yes Yes 4 8 1 2
R:R:F119 R:R:I118 10.05 1 Yes No 7 3 1 2
R:R:F119 W:W:?1 7.57 1 Yes Yes 7 0 1 0
R:R:M123 W:W:?1 10.54 0 No Yes 5 0 1 0
R:R:Q127 W:W:?1 5.79 1 Yes Yes 4 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
12.50Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
11.76Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.11Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
10.00Single4DJHJDTic4DJH-κ-JDTic
10.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
9.68Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
9.52Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.09Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
9.09Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
9.09Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
9.09Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
9.09Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70Consensuskisspeptin_onOrthosteric Ligandkiss1_on
8.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
8.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
8.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
7.69Single7WC4Serotonin7WC4-5-HT2A-Serotonin
7.69Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
7.69Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.69Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.14Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
6.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
6.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
6.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
6.45Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
6.25Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
6.25Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
6.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.25Single6LI0C176LI0-GPR52-C17
6.25Single6TP4ACT-4622066TP4-OX1-ACT-462206
6.25Single7FEEZCZ0117FEE-CB1-CP55940-ZCZ011
6.25Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
6.25Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.06Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
5.88Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
5.88Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
5.88Single6DS0Ly2660976DS0-5-HT2B-Ly266097
5.88Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
5.88Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
5.88Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.88Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.88Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.88Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
5.88Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
5.88Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
5.88Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
5.88Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
5.88Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
5.88Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.56Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.56Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
5.56Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
5.56Single6KUXRS-799486KUX-α2a-RS-79948
5.56Single6TP3Nemorexant6TP3-OX1-Nemorexant
5.56Single6TPKRetosiban6TPK-OT-Retosiban
5.56Single6VI4JDTic6VI4-κ-JDTic
5.56Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.56Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.56Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
5.56Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
5.56Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
5.56Single8IHKAcifran8IHK-HCA3-Acifran
5.56Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
5.56Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.56Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
5.56Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.56Consensusopsins_offOrthosteric Ligandrhodopsin_off
5.56Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
5.56Consensussensory_offOrthosteric Ligandopsins_off
5.56Consensusvasop-oxy_offOrthosteric Ligandot_off
5.41Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.41Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.26Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
5.26Single2Y01Dobutamine2Y01-β1-Dobutamine
5.26Single2Y02Carmoterol2Y02-β1-Carmoterol
5.26Single2Y04Salbutamol2Y04-β1-Salbutamol
5.26Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
5.26Single4QKX35V4QKX-β2-35V
5.26Single6DRXLisuride6DRX-5-HT2B-Lisuride
5.26Single6H7MSalbutamol6H7M-β1-Salbutamol
5.26Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
5.26Single7BU7BI1671077BU7-β1-BI167107
5.26Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
5.26Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
5.26Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.26Single7WC7Lisuride7WC7-5-HT2A-Lisuride
5.26Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
5.26Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
5.26Single7YXAONO-54306087YXA-S1P5-ONO-5430608
5.26Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
5.26Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
5.26Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
5.26Single8JXRLSD8JXR-D1-LSD
5.26Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
5.26Consensus5ht5_onOrthosteric Ligand5ht5a_on
5.26Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.13Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
5.00Single2Y00Dobutamine2Y00-β1-Dobutamine
5.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
5.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
5.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
5.00Single5TVNLSD5TVN-5-HT2B-LSD
5.00Single5WIUNemonapride5WIU-D4-Nemonapride
5.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
5.00Single5XPRBosentan5XPR-ETB-Bosentan
5.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
5.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
5.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
5.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
5.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
5.00Single6TP6Filorexant6TP6-OX1-Filorexant
5.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
5.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
5.00Single7C4SS1P7C4S-S1P3-S1P
5.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
5.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
5.00Single7WC6LSD7WC6-5-HT2A-LSD
5.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
5.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
5.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
5.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
5.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
5.00Single8JXSPF-61428JXS-D1-PF-6142
5.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
5.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
5.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
5.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
5.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
5.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
5.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
5.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
5.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
5.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
4.76Single3P0GBI1671073P0G-β2-BI167107
4.76Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
4.76Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
4.76Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
4.76Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
4.76Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
4.76Single6H7JIsoprenaline6H7J-β1-Isoprenaline
4.76Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
4.76Single6WGTLSD6WGT-5-HT2A-LSD
4.76Single7B6WCyclazosin7B6W-α1b-Cyclazosin
4.76Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
4.76Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
4.76Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
4.76Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
4.76Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
4.76Single7R0CAVP7R0C-V2-AVP-Arrestin2
4.76Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
4.76Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
4.76Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
4.76Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
4.76Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
4.76Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
4.76Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
4.76Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
4.76Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
4.76Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
4.76Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
4.76Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
4.76Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
4.76Single9BJKNAM9BJK-μ-Naloxone-NAM
4.76Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
4.76Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.76Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.76Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
4.76Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
4.76Consensuslpa_onOrthosteric Ligandlpa1_on
4.76Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
4.65Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
4.55Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
4.55Single4AMIBucindolol4AMI-β1-Bucindolol
4.55Single4LDEBI1671074LDE-β2-BI167107
4.55Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
4.55Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
4.55Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.55Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
4.55Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
4.55Single6IIURamatroban6IIU-TP-Ramatroban
4.55Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
4.55Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.55Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
4.55Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
4.55Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
4.55Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
4.55Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
4.55Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
4.55Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
4.55Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
4.55Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
4.55Single8JJ8Formoterol8JJ8-β2-Formoterol
4.55Single8JJLOlodaterol8JJL-β2-Olodaterol
4.55Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
4.55Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.55Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
4.55Consensusalpha1_offOrthosteric Ligandalpha1a_off
4.55Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
4.55Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
4.55Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
4.55Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
4.55Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
4.55Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.55Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
4.55Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
4.35Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
4.35Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.35Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
4.35Single5X93K-87945X93-ETB-K-8794
4.35Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
4.35Single6H7LDobutamine6H7L-β1-Dobutamine
4.35Single6IBLArformoterol6IBL-β1-Arformoterol
4.35Single6K1QIRL25006K1Q-ETB-IRL2500
4.35Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
4.35Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
4.35Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
4.35Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
4.35Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.35Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
4.35Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
4.35Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
4.35Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
4.35Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
4.35Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
4.35Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
4.35Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
4.35Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
4.35Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
4.35Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
4.35Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
4.35Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.35Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.35Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.35Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single5EE7MK08935EE7-Glucagon-MK0893
4.17Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
4.17Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.17Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
4.17Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
4.17Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
4.17Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
4.17Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8X5YAstemizole8X5Y-H1-Astemizole
4.17Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.17Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
4.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
4.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
4.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
4.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
4.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
4.00Single8WKYPG-9348WKY-MC4-PG-934
4.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
4.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
4.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.85Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
3.85Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.85Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.85Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.85Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
3.85Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.85Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
3.85Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
3.85Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
3.85Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
3.85Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
3.70Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
3.70Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
3.70Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
3.70Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.70Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
3.70Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
3.57Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
3.57Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
3.57Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
3.57Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
3.57Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.57Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
3.57Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.57Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
3.57Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.57Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
3.57Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
3.57Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
3.57Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
3.57Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
3.57Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
3.57Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
3.57Consensusvasop-oxy_onOrthosteric Ligandv2_on
3.57Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
3.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
3.45Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
3.45Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
3.45Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
3.45Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
3.45Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
3.45Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
3.45Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.45Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
3.33Single6FJ3PTH6FJ3-PTH1-PTH
3.33Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.33Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.33Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
3.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
3.33Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
3.33Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
3.33Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.33Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.33Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
3.33Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
3.33Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
3.33Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
3.23Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.23Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
3.23Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.23Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.23Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
3.23Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
3.23Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
3.23Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
3.23Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
3.23Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.23Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
3.23Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.23Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
3.23Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
3.23Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.23Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
3.12Single6IGLIRL16206IGL-ETB-IRL1620
3.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
3.12Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
3.12Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.12Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
3.12Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
3.12Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
3.12Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.12Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
3.12Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
3.12Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.12Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
3.12Consensusendothelin_onOrthosteric Ligandetb_on eta_on
3.12Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
3.03Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
3.03Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
3.03Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
3.03Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03Consensusbombesin_onOrthosteric Ligandbb2_on
3.03Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
3.03Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
3.03Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
2.94Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
2.94Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
2.94Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
2.94Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
2.94Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
2.94Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
2.86Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
2.86Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
2.86Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.86Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.86Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.86Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
2.78Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
2.78Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
2.78Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
2.78Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.78Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
2.78Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.56Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
2.44Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3

PDB Summary
PDB 4XNV
Class A
SubFamily Nucleotide
Type P2Y
SubType P2Y1
Species Homo Sapiens
Ligand -
Other Ligand(s) BPTU
Protein Partners -
PDB Resolution 2.2
Date 2015-04-01
D.O.I. 10.1038/nature14287
Net Summary
Imin 4.36
Number of Linked Nodes 267
Number of Links 292
Number of Hubs 35
Number of Links mediated by Hubs 134
Number of Communities 9
Number of Nodes involved in Communities 45
Number of Links involved in Communities 56
Path Summary
Number Of Nodes in MetaPath 60
Number Of Links MetaPath 59
Number of Shortest Paths 94746
Length Of Smallest Path 3
Average Path Length 18.0932
Length of Longest Path 39
Minimum Path Strength 1.255
Average Path Strength 7.62024
Maximum Path Strength 21.325
Minimum Path Correlation 0.7
Average Path Correlation 0.921478
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 37.9364
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.2892
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • binding   • metal ion binding   • small molecule binding   • A1 adenosine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • adenosine receptor binding   • adenyl ribonucleotide binding   • nucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • purine nucleotide binding   • anion binding   • adenyl nucleotide binding   • ATP binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • ADP binding   • G protein-coupled purinergic nucleotide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • purinergic nucleotide receptor activity   • nucleotide receptor activity   • G protein-coupled ATP receptor activity   • protein heterodimerization activity   • protein dimerization activity   • scaffold protein binding   • G protein-coupled ADP receptor activity   • alkane metabolic process   • catabolic process   • hydrocarbon catabolic process   • metabolic process   • cellular process   • alkane catabolic process   • hydrocarbon metabolic process   • multicellular organismal process   • regulation of biological process   • regulation of penile erection   • regulation of reproductive process   • reproductive process   • multicellular organismal reproductive process   • biological regulation
Gene OntologyBiological Process• alkane metabolic process   • catabolic process   • hydrocarbon catabolic process   • metabolic process   • cellular process   • alkane catabolic process   • hydrocarbon metabolic process   • multicellular organismal process   • regulation of biological process   • regulation of penile erection   • regulation of reproductive process   • reproductive process   • multicellular organismal reproductive process   • biological regulation   • positive regulation of biological process   • mating behavior   • behavior   • positive regulation of penile erection   • positive regulation of multicellular organismal process   • reproductive behavior   • regulation of multicellular organismal process   • penile erection   • copulation   • positive regulation of reproductive process   • positive regulation of cell communication   • regulation of localization   • regulation of cellular process   • regulation of hormone secretion   • signaling   • transport   • positive regulation of secretion by cell   • hormone secretion   • cell communication   • localization   • positive regulation of hormone secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of secretion   • signal release   • regulation of biological quality   • positive regulation of cellular process   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • export from cell   • cell-cell signaling   • establishment of localization   • regulation of secretion   • positive regulation of transport   • regulation of cell communication   • hormone transport   • positive regulation of signaling   • monoatomic ion transport   • protein localization   • protein localization to cell periphery   • cellular localization   • protein localization to plasma membrane   • cellular macromolecule localization   • macromolecule localization   • localization within membrane   • protein localization to membrane   • cellular response to stimulus   • purinergic nucleotide receptor signaling pathway   • response to stimulus   • cell surface receptor signaling pathway   • G protein-coupled purinergic receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • G protein-coupled adenosine receptor signaling pathway   • regulation of body fluid levels   • wound healing   • cell activation   • hemostasis   • blood coagulation   • response to stress   • coagulation   • response to wounding   • platelet activation   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • signal transduction involved in regulation of gene expression   • biosynthetic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of metabolic process   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • cellular response to ATP   • response to organophosphorus   • response to oxygen-containing compound   • response to nitrogen compound   • response to ATP   • response to purine-containing compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • response to chemical   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • regulation of cytosolic calcium ion concentration   • regulation of presynaptic cytosolic calcium ion concentration   • cellular homeostasis   • neuron cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • regulation of inositol phosphate biosynthetic process   • regulation of inositol trisphosphate biosynthetic process   • alcohol metabolic process   • inositol phosphate metabolic process   • positive regulation of phosphate metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • positive regulation of inositol trisphosphate biosynthetic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • regulation of phosphate metabolic process   • phosphate-containing compound metabolic process   • polyol biosynthetic process   • inositol trisphosphate metabolic process   • small molecule metabolic process   • phosphorus metabolic process   • regulation of carbohydrate metabolic process   • carbohydrate metabolic process   • polyol metabolic process   • regulation of alcohol biosynthetic process   • positive regulation of phosphorus metabolic process   • small molecule biosynthetic process   • inositol trisphosphate biosynthetic process   • carbohydrate biosynthetic process   • primary metabolic process   • positive regulation of inositol phosphate biosynthetic process   • organophosphate metabolic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • alcohol biosynthetic process   • regulation of phosphorus metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of carbohydrate metabolic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of nucleobase-containing compound metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • regulation of DNA-templated transcription   • regulated exocytosis   • modulation of chemical synaptic transmission   • synaptic vesicle cycle   • synaptic vesicle exocytosis   • vesicle-mediated transport   • vesicle-mediated transport in synapse   • regulation of regulated secretory pathway   • synaptic signaling   • establishment of localization in cell   • trans-synaptic signaling   • neurotransmitter secretion   • regulation of neurotransmitter transport   • regulation of synaptic vesicle exocytosis   • neurotransmitter transport   • regulation of vesicle-mediated transport   • chemical synaptic transmission   • signal release from synapse   • regulation of trans-synaptic signaling   • exocytosis   • regulation of neurotransmitter secretion   • anterograde trans-synaptic signaling   • regulation of exocytosis   • regulation of monoatomic ion transport   • positive regulation of monoatomic ion transport   • positive regulation of cytosolic calcium ion concentration   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • eating behavior   • feeding behavior   • developmental process   • regulation of developmental process   • regulation of cell shape   • cell morphogenesis   • regulation of cell morphogenesis   • anatomical structure morphogenesis   • anatomical structure development   • regulation of anatomical structure morphogenesis   • cellular response to purine-containing compound   • response to mechanical stimulus   • response to abiotic stimulus   • response to external stimulus   • response to endogenous stimulus   • response to growth factor   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular developmental process   • glial cell migration   • nervous system development   • neurogenesis   • multicellular organism development   • gliogenesis   • cell differentiation   • cell migration   • cell motility   • system development   • positive regulation of phosphorylation   • regulation of protein modification process   • regulation of protein phosphorylation   • positive regulation of protein metabolic process   • positive regulation of protein modification process   • protein metabolic process   • positive regulation of protein phosphorylation   • protein modification process   • protein phosphorylation   • phosphorylation   • regulation of protein metabolic process   • macromolecule modification   • regulation of phosphorylation   • regulation of tube diameter   • system process   • regulation of tube size   • circulatory system process   • vascular process in circulatory system   • blood vessel diameter maintenance   • blood circulation   • regulation of anatomical structure size   • monoamine transport   • nitrogen compound transport   • negative regulation of amine transport   • regulation of catecholamine secretion   • negative regulation of biological process   • negative regulation of transport   • organic hydroxy compound transport   • negative regulation of secretion   • catecholamine transport   • negative regulation of cellular process   • negative regulation of norepinephrine secretion   • negative regulation of secretion by cell   • norepinephrine transport   • negative regulation of catecholamine secretion   • organic cation transport   • catecholamine secretion   • amine transport   • norepinephrine secretion   • regulation of amine transport   • regulation of norepinephrine secretion   • muscle system process   • relaxation of muscle   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • somatodendritic compartment
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • glutamatergic synapse   • cell body   • membrane-bounded organelle   • organelle   • cilium   • apical part of cell   • apical plasma membrane   • cell surface   • presynaptic active zone membrane   • presynaptic membrane   • presynapse   • presynaptic active zone   • postsynaptic density   • neuron to neuron synapse   • postsynaptic specialization   • asymmetric synapse
SCOP2Domain Identifier• G protein-coupled receptor-like   • Rubredoxin-like
SCOP2Family Identifier• G protein-coupled receptor-like   • Rubredoxin-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeBUR
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeBUR
Name1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea
Synonyms
Identifier
FormulaC23 H22 F3 N3 O3
Molecular Weight445.434
SMILES
PubChem11510579
Formal Charge0
Total Atoms54
Total Chiral Atoms0
Total Bonds56
Total Aromatic Bonds18

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP47900
Sequence
>4XNV_Chain_R
SFKCALTKT GFQFYYLPA VYILVFIIG FLGNSVAIW MFVFHMKPW 
SGISVYMFN LALADFLYV LTLPALIFY YFNKTDWIF GDAMCKLQR 
FIFHVNLYG SILFLTCIS AHRYSGVVY PKSLGRLKK KNAICISVL 
VWLIVVVAI SPILFYSGT GVRKNKTIT CYDTTSDEY LRSYFIYSM 
CTTVAMFCV PLVLILGCY GLIVRALIY KPLRRKSIY LVIIVLTVF 
AVSYIPFHV MKTMNLRAR LDFQTPAMC AFNDRVYAT YQVTRGLAS 
LNSCVNPIL YFLAGDTFR RR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WJXANucleotideP2YP2Y1Homo sapiensADP-chim(Gs-CtGq)/β1/γ23.22024-10-02To be published
8KGGANucleotideP2YP2Y10Homo sapiensLPS-chim(NtGi2-G13)/β1/γ23.062024-07-31To be published
7XXHANucleotideP2YP2Y1Homo sapiens2MeSADP-chim(NtGi1-G11)/β1/γ22.92023-06-0710.1093/procel/pwac025
4XNWANucleotideP2YP2Y1Homo sapiensMRS2500--2.72015-04-0110.1038/nature14287




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Download 4XNV.zip



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