psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F40	R:R:P293	17.34	No	No	0	5	1
2	R:R:C42	R:R:Q291	9.16	No	No	0	8	2
3	R:R:C296	R:R:C42	7.28	No	No	0	4	8
4	R:R:L44	R:R:Y303	12.89	No	Yes	0	2	4
5	R:R:F49	R:R:K46	11.17	No	Yes	0	4	4
6	R:R:K46	R:R:Q50	16.27	Yes	Yes	2	4	4
7	R:R:K46	R:R:Y303	5.97	Yes	Yes	2	4	4
8	R:R:A304	R:R:K46	4.82	No	Yes	0	3	4
9	R:R:F51	R:R:Q50	11.71	No	Yes	0	3	4
10	R:R:Q50	R:R:Y303	10.15	Yes	Yes	2	4	4
11	R:R:Q307	R:R:Q50	8.96	No	Yes	2	5	4
12	R:R:V57	R:R:Y53	6.31	No	Yes	0	4	5
13	R:R:L54	R:R:Y58	10.55	Yes	Yes	0	6	7
14	R:R:L54	R:R:Y111	5.86	Yes	No	0	6	5
15	R:R:L54	R:R:R310	4.86	Yes	Yes	0	6	5
16	R:R:P55	R:R:Y111	11.13	No	No	0	6	5
17	R:R:L104	R:R:Y58	4.69	No	Yes	0	7	7
18	R:R:L107	R:R:Y58	9.38	No	Yes	0	7	7
19	R:R:S314	R:R:Y58	5.09	No	Yes	0	7	7
20	R:R:I108	R:R:I59	5.89	No	No	5	7	5
21	R:R:F62	R:R:F66	5.36	No	Yes	1	6	5
22	R:R:F62	R:R:P105	13	No	No	1	6	9
23	R:R:F62	W:W:?1	12.87	No	Yes	1	6	0
24	R:R:C318	R:R:I64	6.55	No	No	0	7	5
25	R:R:F66	R:R:S70	7.93	Yes	No	1	5	3
26	R:R:F66	R:R:F98	6.43	Yes	Yes	1	5	7
27	R:R:F66	W:W:?1	12.11	Yes	Yes	1	5	0
28	R:R:D97	R:R:N69	5.39	Yes	No	0	9	9
29	R:R:N69	R:R:P321	8.15	No	No	0	9	9
30	R:R:F98	R:R:S70	5.28	Yes	No	1	7	3
31	R:R:F98	R:R:I73	5.02	Yes	No	0	7	7
32	R:R:H79	R:R:W74	5.29	No	No	0	5	3
33	R:R:F331	R:R:M75	12.44	Yes	No	0	8	7
34	R:R:F76	R:R:S87	5.28	Yes	No	0	6	7
35	R:R:F76	R:R:F91	6.43	Yes	No	0	6	5
36	R:R:F76	R:R:Y324	7.22	Yes	Yes	0	6	9
37	R:R:F331	R:R:F76	12.86	Yes	Yes	0	8	6
38	R:R:F78	R:R:V77	11.8	No	No	0	5	3
39	R:R:M80	R:R:W83	5.82	No	No	0	5	6
40	R:R:M80	R:R:S87	4.6	No	No	0	5	7
41	R:R:F331	R:R:M80	7.46	Yes	No	0	8	5
42	R:R:K81	R:R:R333	14.85	No	No	0	6	5
43	R:R:F91	R:R:W83	15.03	No	No	0	5	6
44	R:R:S84	R:R:S87	6.52	No	No	0	7	7
45	R:R:D329	R:R:S84	7.36	No	No	0	5	7
46	R:R:G85	R:R:H148	4.77	No	Yes	0	6	8
47	R:R:H148	R:R:I86	5.3	Yes	No	0	8	7
48	R:R:I86	R:R:R149	6.26	No	Yes	0	7	9
49	R:R:D329	R:R:I86	9.8	No	No	0	5	7
50	R:R:A168	R:R:V88	5.09	No	No	0	8	6
51	R:R:I169	R:R:V88	6.14	No	No	0	4	6
52	R:R:C144	R:R:Y89	13.44	No	Yes	0	6	7
53	R:R:I145	R:R:Y89	4.84	No	Yes	0	8	7
54	R:R:H148	R:R:Y89	4.36	Yes	Yes	0	8	7
55	R:R:A168	R:R:Y89	6.67	No	Yes	0	8	7
56	R:R:I171	R:R:Y89	8.46	No	Yes	0	5	7
57	R:R:I145	R:R:M90	4.37	No	No	0	8	8
58	R:R:M90	R:R:Y324	5.99	No	Yes	0	8	9
59	R:R:F91	R:R:L95	4.87	No	No	0	5	5
60	R:R:F141	R:R:N92	10.87	Yes	No	4	7	9
61	R:R:N92	R:R:S172	7.45	No	No	4	9	7
62	R:R:N92	R:R:W176	7.91	No	No	4	9	9
63	R:R:L93	R:R:N320	9.61	No	No	0	9	9
64	R:R:L93	R:R:Y324	10.55	No	Yes	0	9	9
65	R:R:D97	R:R:N134	6.73	Yes	Yes	3	9	8
66	R:R:D97	R:R:S138	4.42	Yes	No	3	9	9
67	R:R:D97	R:R:S317	8.83	Yes	Yes	3	9	9
68	R:R:D97	R:R:N320	6.73	Yes	No	0	9	9
69	R:R:F98	R:R:L102	8.53	Yes	No	0	7	5
70	R:R:I130	R:R:L99	8.56	No	No	0	4	7
71	R:R:L104	R:R:Y100	8.21	No	Yes	0	7	7
72	R:R:F131	R:R:Y100	8.25	No	Yes	0	7	7
73	R:R:N134	R:R:Y100	10.47	Yes	Yes	3	8	7
74	R:R:S314	R:R:Y100	5.09	No	Yes	0	7	7
75	R:R:S317	R:R:Y100	6.36	Yes	Yes	3	9	7
76	R:R:L102	W:W:?1	5.16	No	Yes	0	5	0
77	R:R:Q127	R:R:T103	8.5	Yes	No	1	4	6
78	R:R:I130	R:R:T103	4.56	No	No	0	4	6
79	R:R:T103	W:W:?1	13.74	No	Yes	1	6	0
80	R:R:P105	W:W:?1	17.35	No	Yes	1	9	0
81	R:R:A106	W:W:?1	7.83	No	Yes	0	6	0
82	R:R:L107	R:R:Q127	11.98	No	Yes	0	7	4
83	R:R:F109	R:R:N113	6.04	No	No	0	3	4
84	R:R:F109	R:R:I118	7.54	No	No	1	3	3
85	R:R:F109	R:R:F119	6.43	No	Yes	1	3	7
86	R:R:T115	R:R:Y110	8.74	No	No	0	4	5
87	R:R:W117	R:R:Y110	8.68	Yes	No	0	8	5
88	R:R:D116	R:R:N113	5.39	No	No	0	5	4
89	R:R:R195	R:R:T115	5.17	Yes	No	0	1	4
90	R:R:D116	R:R:T199	10.12	No	No	0	5	4
91	R:R:F119	R:R:W117	12.03	Yes	Yes	1	7	8
92	R:R:C124	R:R:W117	6.53	No	Yes	1	9	8
93	R:R:Q127	R:R:W117	7.67	Yes	Yes	1	4	8
94	R:R:T192	R:R:W117	4.85	No	Yes	0	5	8
95	R:R:C202	R:R:W117	13.06	No	Yes	1	9	8
96	R:R:F119	R:R:I118	10.05	Yes	No	1	7	3
97	R:R:F119	W:W:?1	7.57	Yes	Yes	1	7	0
98	R:R:D121	R:R:K125	8.3	No	No	0	3	7
99	R:R:D121	R:R:T192	5.78	No	No	0	3	5
100	R:R:M123	W:W:?1	10.54	No	Yes	0	5	0
101	R:R:C124	R:R:C202	7.28	No	No	1	9	9
102	R:R:I130	R:R:L126	7.14	No	No	0	4	4
103	R:R:Q127	W:W:?1	5.79	Yes	Yes	1	4	0
104	R:R:R128	R:R:S190	5.27	No	No	0	5	5
105	R:R:C202	R:R:R128	8.36	No	No	0	9	5
106	R:R:D204	R:R:R128	8.34	No	No	0	6	5
107	R:R:F129	R:R:V133	7.87	Yes	No	0	6	5
108	R:R:F129	R:R:L187	14.61	Yes	No	0	6	5
109	R:R:F131	R:R:H132	10.18	No	No	0	7	5
110	R:R:F131	R:R:F276	6.43	No	No	0	7	7
111	R:R:H132	R:R:I186	13.26	No	No	0	5	4
112	R:R:V133	R:R:V179	4.81	No	No	0	5	7
113	R:R:N134	R:R:S138	4.47	Yes	No	3	8	9
114	R:R:N134	R:R:S317	4.47	Yes	Yes	3	8	9
115	R:R:L135	R:R:Y136	14.07	No	Yes	7	7	7
116	R:R:H277	R:R:L135	5.14	Yes	No	7	8	7
117	R:R:I183	R:R:Y136	4.84	No	Yes	0	7	7
118	R:R:M225	R:R:Y136	10.78	No	Yes	0	5	7
119	R:R:H277	R:R:Y136	8.71	Yes	Yes	7	8	7
120	R:R:I139	R:R:Y273	8.46	No	No	0	7	8
121	R:R:L140	R:R:V175	4.47	No	No	0	5	7
122	R:R:F141	R:R:S172	6.61	Yes	No	4	7	7
123	R:R:F141	R:R:V175	11.8	Yes	No	0	7	7
124	R:R:F141	R:R:W176	9.02	Yes	No	4	7	9
125	R:R:P229	R:R:T143	6.99	No	No	0	9	8
126	R:R:L232	R:R:T143	4.42	No	No	0	6	8
127	R:R:I233	R:R:T143	7.6	No	No	0	8	8
128	R:R:I233	R:R:S146	6.19	No	No	8	8	9
129	R:R:S146	R:R:Y237	10.17	No	Yes	8	9	9
130	R:R:H148	R:R:K164	5.24	Yes	No	0	8	6
131	R:R:L254	R:R:R149	4.86	No	Yes	0	4	9
132	R:R:K257	R:R:R149	6.19	No	Yes	0	8	9
133	R:R:R149	R:R:S258	5.27	Yes	No	0	9	7
134	R:R:V154	R:R:Y150	6.31	No	Yes	9	7	7
135	R:R:Y150	R:R:Y155	4.96	Yes	No	9	7	6
136	R:R:C236	R:R:Y150	5.38	No	Yes	0	6	7
137	R:R:L239	R:R:Y150	8.21	No	Yes	0	4	7
138	R:R:L254	R:R:V153	4.47	No	No	0	4	8
139	R:R:V154	R:R:Y155	7.57	No	No	9	7	6
140	R:R:K164	R:R:L160	16.92	No	No	0	6	5
141	R:R:P185	R:R:S184	5.34	No	No	0	8	4
142	R:R:P185	R:R:Y217	16.69	No	Yes	0	8	5
143	R:R:I186	R:R:Y217	7.25	No	Yes	0	4	5
144	R:R:F188	R:R:Y189	7.22	No	Yes	0	4	4
145	R:R:F188	R:R:Y210	12.38	No	No	0	4	4
146	R:R:T206	R:R:Y189	7.49	No	Yes	0	5	4
147	R:R:S213	R:R:Y189	7.63	No	Yes	0	1	4
148	R:R:Y189	R:R:Y214	14.89	Yes	Yes	0	4	4
149	R:R:Y189	R:R:Y217	8.94	Yes	Yes	0	4	5
150	R:R:K198	R:R:V194	4.55	No	No	0	2	2
151	R:R:N197	R:R:R195	4.82	No	Yes	6	4	1
152	R:R:R195	R:R:T199	9.06	Yes	No	6	1	4
153	R:R:R195	R:R:T201	15.52	Yes	No	0	1	3
154	R:R:N197	R:R:T199	8.77	No	No	6	4	4
155	R:R:D204	R:R:Y306	4.6	No	No	2	6	4
156	R:R:D204	R:R:R310	16.68	No	Yes	2	6	5
157	R:R:T205	R:R:Y214	6.24	No	Yes	0	5	4
158	R:R:R287	R:R:T205	6.47	No	No	0	5	5
159	R:R:S207	R:R:Y210	5.09	No	No	0	5	4
160	R:R:E209	R:R:Y210	17.96	No	No	0	3	4
161	R:R:L211	R:R:R287	10.93	No	No	0	4	5
162	R:R:L211	R:R:L288	8.3	No	No	0	4	3
163	R:R:L288	R:R:R212	15.79	No	No	0	3	1
164	R:R:D289	R:R:R212	8.34	No	No	0	1	1
165	R:R:S218	R:R:Y214	8.9	No	Yes	0	5	4
166	R:R:L284	R:R:Y214	4.69	No	Yes	0	4	4
167	R:R:F215	R:R:M219	7.46	No	No	0	4	4
168	R:R:F215	R:R:L284	6.09	No	No	0	4	4
169	R:R:T221	R:R:Y217	4.99	No	Yes	0	5	5
170	R:R:K280	R:R:S218	6.12	No	No	0	6	5
171	R:R:M219	R:R:T281	4.52	No	No	0	4	5
172	R:R:H277	R:R:T222	8.21	Yes	No	0	8	5
173	R:R:F226	R:R:H277	33.94	Yes	Yes	0	8	8
174	R:R:F269	R:R:L230	8.53	No	No	0	9	6
175	R:R:I233	R:R:Y237	7.25	No	Yes	8	8	9
176	R:R:L261	R:R:Y237	8.21	No	Yes	0	7	9
177	R:R:V262	R:R:Y237	16.4	No	Yes	0	7	9
178	R:R:V265	R:R:Y237	8.83	No	Yes	0	7	9
179	R:R:L266	R:R:Y237	4.69	No	Yes	0	7	9
180	R:R:R242	R:R:Y246	5.14	No	No	0	5	5
181	R:R:L244	R:R:R255	9.72	No	No	0	8	6
182	R:R:K247	R:R:R255	4.95	No	No	0	4	6
183	R:R:D329	R:R:K257	5.53	No	No	0	5	8
184	R:R:L326	R:R:Y260	12.89	No	No	0	6	6
185	R:R:I264	R:R:L323	5.71	No	No	0	4	7
186	R:R:N316	R:R:V268	4.43	No	No	0	9	6
187	R:R:F269	R:R:Y273	14.44	No	No	0	9	8
188	R:R:N316	R:R:S272	8.94	No	No	0	9	8
189	R:R:N316	R:R:Y273	17.44	No	No	0	9	8
190	R:R:A313	R:R:F276	6.93	No	No	0	7	7
191	R:R:M279	R:R:M282	5.78	No	No	0	5	5
192	R:R:M279	R:R:T305	6.02	No	No	0	5	4
193	R:R:M279	R:R:T309	7.53	No	No	0	5	7
194	R:R:M282	R:R:V302	4.56	No	No	0	5	4
195	R:R:N283	R:R:Y303	5.81	No	Yes	0	4	4
196	R:R:N283	R:R:Y306	11.63	No	No	0	4	4
197	R:R:D289	R:R:R285	7.15	No	No	0	1	4
198	R:R:F290	R:R:R285	10.69	No	No	0	3	4
199	R:R:A286	R:R:N299	6.25	No	No	0	1	2
200	R:R:F290	R:R:M295	9.95	No	Yes	0	3	4
201	R:R:F298	R:R:M295	4.98	No	Yes	0	1	4
202	R:R:M295	R:R:N299	5.61	Yes	No	0	4	2
203	R:R:F298	R:R:V302	7.87	No	No	0	1	4
204	R:R:Q307	R:R:Y303	16.91	No	Yes	2	5	4
205	R:R:R310	R:R:Y306	14.4	Yes	No	2	5	4
206	R:R:Q307	R:R:R310	9.35	No	Yes	2	5	5
207	R:R:F325	R:R:F331	5.36	No	Yes	0	6	8
208	R:R:G311	R:R:Y53	4.35	No	Yes	0	4	5
209	R:R:G193	R:R:Y203	4.35	No	No	0	2	4
210	R:R:F226	R:R:F269	4.29	Yes	No	0	8	9
211	R:R:I145	R:R:L261	4.28	No	No	0	8	7
212	R:R:D116	R:R:I200	4.2	No	No	0	5	4
213	R:R:L142	R:R:L93	4.15	No	No	0	8	9
214	R:R:L160	R:R:L163	4.15	No	No	0	5	8
215	R:R:L230	R:R:L234	4.15	No	No	0	6	4
216	R:R:L261	R:R:L323	4.15	No	No	0	7	7
217	R:R:G68	R:R:P321	4.06	No	No	0	6	9
218	R:R:A94	R:R:Y324	4	No	Yes	0	9	9
219	R:R:H132	R:R:I183	3.98	No	No	0	5	7
220	R:R:H79	R:R:M75	3.94	No	No	0	5	7
221	R:R:C124	R:R:G191	3.92	No	No	0	9	4
222	R:R:F129	R:R:I183	3.77	Yes	No	0	6	7
223	R:R:F226	R:R:I274	3.77	Yes	No	0	8	5
224	R:R:G137	R:R:V179	3.68	No	No	0	6	7
225	R:R:P229	R:R:V228	3.53	No	No	0	9	6
226	R:R:L54	R:R:Y53	3.52	Yes	Yes	0	6	5
227	R:R:P275	R:R:T309	3.5	No	No	0	9	7
228	R:R:G328	R:R:M90	3.49	No	No	0	8	8
229	R:R:L140	R:R:P229	3.28	No	No	0	5	9
230	R:R:S314	R:R:V61	3.23	No	No	0	7	6
231	R:R:S317	R:R:V101	3.23	Yes	No	0	9	5
232	R:R:S272	R:R:V271	3.23	No	No	0	8	6
233	R:R:A182	R:R:M225	3.22	No	No	0	4	5
234	R:R:C170	R:R:L174	3.17	No	No	0	3	3
235	R:R:A327	R:R:L323	3.15	No	No	0	6	7
236	R:R:I240	R:R:S258	3.1	No	No	0	7	7
237	R:R:R256	R:R:Y260	3.09	No	No	0	5	6
238	R:R:M282	R:R:V278	3.04	No	No	0	5	6
239	R:R:F78	R:R:W74	3.01	No	No	0	5	3
240	R:R:M295	R:R:T292	3.01	Yes	No	0	4	2
241	R:R:L315	R:R:V61	2.98	No	No	0	5	6
242	R:R:L177	R:R:V173	2.98	No	No	0	4	4
243	R:R:L312	R:R:V308	2.98	No	No	0	7	5
244	R:R:I59	R:R:I63	2.94	No	No	0	5	5
245	R:R:I259	R:R:I263	2.94	No	No	0	6	4
246	R:R:I169	R:R:K165	2.91	No	No	0	4	3
247	R:R:G48	R:R:Y52	2.9	No	No	0	4	3
248	R:R:F112	R:R:P55	2.89	No	No	0	4	6
249	R:R:I64	R:R:L60	2.85	No	No	0	5	5
250	R:R:I322	R:R:L326	2.85	No	No	0	6	6
251	R:R:G120	R:R:W117	2.81	No	Yes	0	6	8
252	R:R:C296	R:R:F40	2.79	No	No	0	4	5
253	R:R:C227	R:R:F226	2.79	No	Yes	0	4	8
254	R:R:D208	R:R:K41	2.77	No	No	0	3	1
255	R:R:K41	R:R:Q291	2.71	No	No	0	1	2
256	R:R:A72	R:R:Y324	2.67	No	Yes	0	8	9
257	R:R:N299	R:R:Q291	2.64	No	No	0	2	2
258	R:R:F129	R:R:V180	2.62	Yes	No	0	6	4
259	R:R:F51	R:R:T47	2.59	No	No	0	3	2
260	R:R:A96	R:R:W176	2.59	No	No	0	8	9
261	R:R:R332	R:R:T330	2.59	No	No	0	8	6
262	R:R:V308	R:R:Y53	2.52	No	Yes	0	5	5
263	R:R:F112	R:R:I59	2.51	No	No	5	4	5
264	R:R:F112	R:R:I108	2.51	No	No	5	4	7
265	R:R:I240	R:R:Y150	2.42	No	Yes	0	7	7
266	R:R:C318	R:R:G65	1.96	No	No	0	7	8
267	R:R:G65	R:R:V101	1.84	No	No	0	8	5
268	R:R:G193	R:R:T192	1.82	No	No	0	2	5
269	R:R:A147	R:R:C236	1.81	No	No	0	6	6
270	R:R:G68	R:R:L67	1.71	No	No	0	6	4
271	R:R:A243	R:R:V153	1.7	No	No	0	5	8
272	R:R:A243	R:R:V154	1.7	No	No	0	5	7
273	R:R:K165	R:R:P82	1.67	No	No	0	3	5
274	R:R:V241	R:R:V262	1.6	No	No	0	5	7
275	R:R:V268	R:R:V319	1.6	No	No	0	6	5
276	R:R:T267	R:R:V271	1.59	No	No	0	4	6
277	R:R:I245	R:R:V241	1.54	No	No	0	3	5
278	R:R:M75	R:R:V71	1.52	No	No	0	7	5
279	R:R:I263	R:R:T267	1.52	No	No	0	4	4
280	R:R:F49	R:R:G48	1.51	No	No	0	4	4
281	R:R:L244	R:R:S258	1.5	No	No	0	8	7
282	R:R:I264	R:R:I322	1.47	No	No	0	4	6
283	R:R:I178	R:R:M225	1.46	No	No	0	5	5
284	R:R:D300	R:R:T45	1.45	No	No	0	2	3
285	R:R:P82	R:R:R334	1.44	No	No	0	5	5
286	R:R:P253	R:R:R256	1.44	No	No	0	4	5
287	R:R:I178	R:R:L174	1.43	No	No	0	5	3
288	R:R:I171	R:R:N167	1.42	No	No	0	5	4
289	R:R:K158	R:R:L160	1.41	No	No	0	5	5
290	R:R:S151	R:R:Y150	1.27	No	Yes	0	5	7
291	R:R:I245	R:R:Y246	1.21	No	No	0	3	5
292	R:R:R332	R:R:R334	1.07	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K46	9.5575	4	2	4
2	R:R:Q50	11.7725	4	2	4
3	R:R:Y53	4.175	4	0	5
4	R:R:L54	6.1975	4	0	6
5	R:R:Y58	7.4275	4	0	7
6	R:R:F66	7.9575	4	1	5
7	R:R:F76	7.9475	4	0	6
8	R:R:Y89	7.554	5	0	7
9	R:R:D97	6.42	5	3	9
10	R:R:F98	6.315	4	1	7
11	R:R:Y100	7.676	5	3	7
12	R:R:W117	7.94714	7	1	8
13	R:R:F119	9.02	4	1	7
14	R:R:Q127	8.485	4	1	4
15	R:R:F129	7.2175	4	0	6
16	R:R:N134	6.535	4	3	8
17	R:R:Y136	9.6	4	7	7
18	R:R:F141	9.575	4	4	7
19	R:R:H148	4.9175	4	0	8
20	R:R:R149	5.645	4	0	9
21	R:R:Y150	4.75833	6	9	7
22	R:R:Y189	9.234	5	0	4
23	R:R:R195	8.6425	4	6	1
24	R:R:Y214	8.68	4	0	4
25	R:R:Y217	9.4675	4	0	5
26	R:R:F226	11.1975	4	0	8
27	R:R:Y237	9.25833	6	8	9
28	R:R:H277	14	4	7	8
29	R:R:M295	5.8875	4	0	4
30	R:R:Y303	10.346	5	2	4
31	R:R:R310	11.3225	4	2	5
32	R:R:S317	5.7225	4	3	9
33	R:R:Y324	6.086	5	0	9
34	R:R:F331	9.53	4	0	8
35	W:W:?1	10.3289	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F290	R:R:M295	14.784	9.95	No	Yes	0	3	4
2	R:R:F290	R:R:R285	15.5314	10.69	No	No	0	3	4
3	R:R:D289	R:R:R285	16.2757	7.15	No	No	0	1	4
4	R:R:D289	R:R:R212	17.0154	8.34	No	No	0	1	1
5	R:R:L288	R:R:R212	17.7535	15.79	No	No	0	3	1
6	R:R:L211	R:R:L288	18.4886	8.3	No	No	0	4	3
7	R:R:L211	R:R:R287	19.2205	10.93	No	No	0	4	5
8	R:R:R287	R:R:T205	19.8799	6.47	No	No	0	5	5
9	R:R:T205	R:R:Y214	20.6072	6.24	No	Yes	0	5	4
10	R:R:Y189	R:R:Y214	25.53	14.89	Yes	Yes	0	4	4
11	R:R:Y189	R:R:Y217	30.368	8.94	Yes	Yes	0	4	5
12	R:R:I186	R:R:Y217	32.9962	7.25	No	Yes	0	4	5
13	R:R:H132	R:R:I186	33.6664	13.26	No	No	0	5	4
14	R:R:F131	R:R:H132	53.9477	10.18	No	No	0	7	5
15	R:R:F131	R:R:Y100	55.6247	8.25	No	Yes	0	7	7
16	R:R:L104	R:R:Y100	44.7058	8.21	No	Yes	0	7	7
17	R:R:L104	R:R:Y58	44.2796	4.69	No	Yes	0	7	7
18	R:R:L54	R:R:Y58	38.3869	10.55	Yes	Yes	0	6	7
19	R:R:L54	R:R:R310	24.8182	4.86	Yes	Yes	0	6	5
20	R:R:Q307	R:R:R310	18.7171	9.35	No	Yes	2	5	5
21	R:R:S314	R:R:Y100	45.8562	5.09	No	Yes	0	7	7
22	R:R:S314	R:R:Y58	44.5776	5.09	No	Yes	0	7	7
23	R:R:L107	R:R:Y58	52.1657	9.38	No	Yes	0	7	7
24	R:R:L107	R:R:Q127	51.0786	11.98	No	Yes	0	7	4
25	R:R:Q127	W:W:?1	20.9052	5.79	Yes	Yes	1	4	0
26	R:R:S317	R:R:Y100	52.944	6.36	Yes	Yes	3	9	7
27	R:R:D97	R:R:N134	50.8424	6.73	Yes	Yes	3	9	8
28	R:R:N134	R:R:Y100	51.406	10.47	Yes	Yes	3	8	7
29	R:R:D97	R:R:S317	51.8785	8.83	Yes	Yes	3	9	9
30	R:R:D97	R:R:N320	100	6.73	Yes	No	0	9	9
31	R:R:L93	R:R:N320	99.407	9.61	No	No	0	9	9
32	R:R:L93	R:R:Y324	98.201	10.55	No	Yes	0	9	9
33	R:R:F76	R:R:Y324	43.2172	7.22	Yes	Yes	0	6	9
34	R:R:F76	R:R:S87	32.6904	5.28	Yes	No	0	6	7
35	R:R:S84	R:R:S87	31.713	6.52	No	No	0	7	7
36	R:R:D329	R:R:S84	30.9579	7.36	No	No	0	5	7
37	R:R:M90	R:R:Y324	55.583	5.99	No	Yes	0	8	9
38	R:R:I145	R:R:M90	54.1284	4.37	No	No	0	8	8
39	R:R:I145	R:R:Y89	30.6876	4.84	No	Yes	0	8	7
40	R:R:H148	R:R:Y89	20.8434	4.36	Yes	Yes	0	8	7
41	R:R:D329	R:R:I86	15.4002	9.8	No	No	0	5	7
42	R:R:H148	R:R:I86	16.1923	5.3	Yes	No	0	8	7
43	R:R:I86	R:R:R149	29.1295	6.26	No	Yes	0	7	9
44	R:R:D329	R:R:K257	14.9616	5.53	No	No	0	5	8
45	R:R:K257	R:R:R149	14.2189	6.19	No	Yes	0	8	9
46	R:R:I233	R:R:T143	10.1052	7.6	No	No	0	8	8
47	R:R:I233	R:R:Y237	10.9869	7.25	No	Yes	8	8	9
48	R:R:L261	R:R:Y237	18.7711	8.21	No	Yes	0	7	9
49	R:R:I145	R:R:L261	26.3763	4.28	No	No	0	8	7
50	R:R:Q127	R:R:W117	25.2737	7.67	Yes	Yes	1	4	8
51	R:R:H132	R:R:I183	24.2607	3.98	No	No	0	5	7
52	R:R:I183	R:R:Y136	19.2236	4.84	No	Yes	0	7	7
53	R:R:H277	R:R:Y136	14.0073	8.71	Yes	Yes	7	8	7
54	R:R:F226	R:R:H277	12.5249	33.94	Yes	Yes	0	8	8
55	R:R:F226	R:R:F269	10.2364	4.29	Yes	No	0	8	9
56	R:R:L254	R:R:R149	10.238	4.86	No	Yes	0	4	9
57	R:R:R149	R:R:S258	30.6583	5.27	Yes	No	0	9	7
58	R:R:I240	R:R:S258	20.4852	3.1	No	No	0	7	7
59	R:R:I240	R:R:Y150	17.9373	2.42	No	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F62	R:R:F66	5.36	1	No	Yes	6	5	1	1
R:R:F62	R:R:P105	13	1	No	No	6	9	1	1
R:R:F62	W:W:?1	12.87	1	No	Yes	6	0	1	0
R:R:F66	R:R:S70	7.93	1	Yes	No	5	3	1	2
R:R:F66	R:R:F98	6.43	1	Yes	Yes	5	7	1	2
R:R:F66	W:W:?1	12.11	1	Yes	Yes	5	0	1	0
R:R:F98	R:R:S70	5.28	1	Yes	No	7	3	2	2
R:R:F98	R:R:L102	8.53	1	Yes	No	7	5	2	1
R:R:L102	W:W:?1	5.16	0	No	Yes	5	0	1	0
R:R:Q127	R:R:T103	8.5	1	Yes	No	4	6	1	1
R:R:I130	R:R:T103	4.56	0	No	No	4	6	2	1
R:R:T103	W:W:?1	13.74	1	No	Yes	6	0	1	0
R:R:P105	W:W:?1	17.35	1	No	Yes	9	0	1	0
R:R:A106	W:W:?1	7.83	0	No	Yes	6	0	1	0
R:R:L107	R:R:Q127	11.98	0	No	Yes	7	4	2	1
R:R:F109	R:R:I118	7.54	1	No	No	3	3	2	2
R:R:F109	R:R:F119	6.43	1	No	Yes	3	7	2	1
R:R:F119	R:R:W117	12.03	1	Yes	Yes	7	8	1	2
R:R:Q127	R:R:W117	7.67	1	Yes	Yes	4	8	1	2
R:R:F119	R:R:I118	10.05	1	Yes	No	7	3	1	2
R:R:F119	W:W:?1	7.57	1	Yes	Yes	7	0	1	0
R:R:M123	W:W:?1	10.54	0	No	Yes	5	0	1	0
R:R:Q127	W:W:?1	5.79	1	Yes	Yes	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
16.67	Single	9KUT	JR14a	9KUT-C3a_B-JR14a-Go/β1/γ2
12.50	Single	7WV9	ZCZ011	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
11.76	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
11.11	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
10.00	Single	4DJH	JDTic	4DJH-κ-JDTic
10.00	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
9.68	Single	8ZJE	TAK448	8ZJE-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ1
9.52	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.09	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
9.09	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
9.09	Single	8XJO	U46619	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	9M1H	PGE2	9M1H-EP₁-PGE2-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
9.09	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
9.09	Consensus	tp_on	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70	Single	8Y72	Peptide	8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
8.70	Single	9JF4	PD168368	9JF4-BB₁-PD168368
8.70	Single	9MD1	Buspirone	9MD1-5-HT_1A-Buspirone-PtdIns4P-Gz/β1/γ2
8.70	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
8.70	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
8.33	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
8.33	Single	8ZJD	Kisspeptin-1	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
8.33	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
8.33	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
8.33	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
8.00	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
7.69	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
7.69	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
7.69	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
7.69	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.69	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
7.69	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
7.14	Single	8IKG	PubChem 703205	8IKG-CB₁-PubChem 703205-Gi1/β1/γ1
7.14	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
6.90	Consensus	secretin_on	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
6.90	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
6.67	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
6.67	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
6.67	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
6.67	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
6.67	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.67	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
6.67	Consensus	secretin_on_gp	Orthosteric Ligand	7D3S-Secretin-Secretin-Gs/β1/γ2
6.45	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
6.45	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
6.45	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
6.25	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
6.25	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
6.25	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
6.25	Single	6LI0	C17	6LI0-GPR52-C17
6.25	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
6.25	Single	7FEE	ZCZ011	7FEE-CB₁-CP55940-ZCZ011
6.25	Single	8IKH	PubChem 171393541	8IKH-CB₁-PubChem 171393541-Gi1/β1/γ1
6.25	Single	8UO4	Constrained Epinephrine	8UO4-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.25	Single	8YKD	Dehydroepiandrosterone	8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
6.25	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
6.25	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
6.06	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
6.06	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
5.88	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
5.88	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
5.88	Single	6DS0	LY266097	6DS0-5-HT_2B-LY266097
5.88	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
5.88	Single	6OBA	Alprenolol	6OBA-β₂-Alprenolol-GTPL11074
5.88	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
5.88	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
5.88	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/β1/γ2
5.88	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
5.88	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.88	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
5.88	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
5.88	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
5.88	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
5.88	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
5.88	Consensus	5ht2_on_gp	Orthosteric Ligand	5ht2b_on_gp
5.88	Consensus	5ht2b_on_gp	Orthosteric Ligand	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
5.88	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.56	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.56	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
5.56	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
5.56	Single	6KUX	RS79948	6KUX-α_2a-RS79948
5.56	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
5.56	Single	6TPK	Retosiban	6TPK-OT-Retosiban
5.56	Single	6VI4	JDTic	6VI4-κ-JDTic
5.56	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.56	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
5.56	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
5.56	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
5.56	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
5.56	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
5.56	Single	8K9L	DAMGO	8K9L-μ-DAMGO-BMS-986122-Gi3/β1/γ1
5.56	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
5.56	Single	8Y6Y	GLPG0974	8Y6Y-FFA2-GLPG0974
5.56	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
5.56	Single	9AS3	LSD	9AS3-5-HT_2A-LSD
5.56	Single	9AS4	LSD	9AS4-5-HT_2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9JKY	Acifran	9JKY-HCA₂-Acifran-Gi1/β1/γ2
5.56	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.56	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
5.56	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
5.56	Consensus	sensory_off	Orthosteric Ligand	opsins_off
5.56	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
5.41	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
5.41	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.41	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
5.26	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
5.26	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
5.26	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.26	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
5.26	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
5.26	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
5.26	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
5.26	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
5.26	Single	6PRZ	Alprenolol	6PRZ-β₂-Alprenolol
5.26	Single	7BU7	BI167107	7BU7-β₁-BI167107
5.26	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
5.26	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
5.26	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.26	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
5.26	Single	7XJH	Isoprenaline	7XJH-β₃-Isoprenaline-Gs/β1/γ2
5.26	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
5.26	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
5.26	Single	8EFQ	DAMGO	8EFQ-μ-DAMGO-Gi1/β1/γ2
5.26	Single	8GCM	L-902688	8GCM-EP₄-L-902688-Gi1/β1/γ2
5.26	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
5.26	Single	8JXR	LSD	8JXR-D₁-LSD
5.26	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
5.26	Single	9BQJ	RO76	9BQJ-μ-RO76-Gi1/β1/γ2
5.26	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.26	Single	9JGK	Balovaptan	9JGK-5-HT_2B-Balovaptan
5.26	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
5.26	Consensus	5ht5a_on	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.13	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
5.00	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
5.00	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
5.00	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
5.00	Single	5JQH	Carazolol	5JQH-β₂-Carazolol
5.00	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
5.00	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
5.00	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
5.00	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
5.00	Single	6E67	BI167107	6E67-β₂-BI167107-Gs(CT)
5.00	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
5.00	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
5.00	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
5.00	Single	6PS3	Carvedilol	6PS3-β₂-Carvedilol
5.00	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
5.00	Single	7BVQ	Carazolol	7BVQ-β₁-Carazolol
5.00	Single	7C4S	S1P	7C4S-S1P₃-S1P
5.00	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/β1/γ2
5.00	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
5.00	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
5.00	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
5.00	Single	7XK9	Constrained Isoproterenol	7XK9-β₂-Constrained Isoproterenol-Na
5.00	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.00	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
5.00	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
5.00	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
5.00	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
5.00	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
5.00	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
5.00	Single	8WGB	VU0155041	8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
5.00	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00	Single	8ZVZ	BW245C	8ZVZ-DP₁-BW245C-Gs/β1/γ2
5.00	Single	9ARZ	2-bromo-LSD	9ARZ-5-HT_2A-2-bromo-LSD
5.00	Single	9EE5	ONO-2550289	9EE5-DP₁-ONO-2550289
5.00	Single	9EKH	ONO-3030297	9EKH-DP₁-ONO-3030297
5.00	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go/β1/γ2
5.00	Single	9HAP	Tolvaptan	9HAP-V₂-Tolvaptan
5.00	Single	9I52	A1IZU	9I52-D₁-A1IZU-Gs/β1/γ2
5.00	Single	9IYB	PGD2	9IYB-DP₂-PGD2-A1D5Q-Gi1/β1/γ2
5.00	Single	9JRT	TG6-129	9JRT-EP₂-TG6-129
5.00	Single	9K07	DSO-5a	9K07-BB₃-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	9KT6	Acifran	9KT6-HCA₃-Acifran-Gi1/β1/γ2
5.00	Single	9L74	S1P d16:1	9L74-S1P₃-S1P d16:1-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	9U81	Tolvaptan	9U81-V₂-Tolvaptan
5.00	Single	9VJF	Buspirone	9VJF-5-HT_1A-Buspirone-Gi3/β1/γ2
5.00	Consensus	5ht5_on_gp	Orthosteric Ligand	5ht5a_on_gp
5.00	Consensus	5ht5a_on_gp	Orthosteric Ligand	7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.00	Consensus	adgrg2_on	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
5.00	Consensus	adgrg2_on_gp	Orthosteric Ligand	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
5.00	Consensus	adrenergic_off	Orthosteric Ligand	alpha_off beta_off
5.00	Consensus	adrenergic_on_gp	Orthosteric Ligand	alpha_on_gp beta_on_gp
5.00	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
5.00	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
5.00	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.00	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
5.00	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
5.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
4.76	Single	3P0G	BI167107	3P0G-β₂-BI167107
4.76	Single	3PDS	FAUC50	3PDS-β₂-FAUC50
4.76	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
4.76	Single	4LDL	Hydroxybenzyl Isoproterenol	4LDL-β₂-Hydroxybenzyl Isoproterenol
4.76	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
4.76	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
4.76	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
4.76	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
4.76	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
4.76	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.76	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
4.76	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
4.76	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
4.76	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/β1/γ2
4.76	Single	7M8W	15r-Methyl-PGD2	7M8W-DP₂-15r-Methyl-PGD2-Na
4.76	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
4.76	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
4.76	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
4.76	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
4.76	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
4.76	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
4.76	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
4.76	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
4.76	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
4.76	Single	8I9L	C3a	8I9L-C3a_B-C3a-Go/β1/γ2
4.76	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
4.76	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
4.76	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
4.76	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
4.76	Single	8Y73	Peptide	8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
4.76	Single	8ZW0	PGD2	8ZW0-DP₁-PGD2-Gs/β1/γ2
4.76	Single	8ZWF	JR14a	8ZWF-C3a_B-JR14a
4.76	Single	9BS9	LSD	9BS9-D₂-LSD
4.76	Single	9BSB	LSD	9BSB-D₂-LSD-chim(NtGi1-Go)/β1/γ2
4.76	Single	9E9S	PGD2	9E9S-DP₁-PGD2-Gs/β1/γ1
4.76	Single	9EGO	Z8526711350	9EGO-CB₁-Z8526711350-Gi1/β1/γ2
4.76	Single	9I54	PubChem 176452091	9I54-D₁-PubChem 176452091-Gs/β1/γ2
4.76	Single	9IZG	LPA	9IZG-LPA₁-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9WST	DAMGO	9WST-μ-DAMGO-chim(NtGi1-Gz)/β1/γ2
4.76	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
4.76	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
4.76	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
4.76	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
4.76	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
4.76	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
4.65	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
4.55	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.55	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.55	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.55	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.55	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.55	Single	6AK3	PGE2	6AK3-EP₃-PGE2
4.55	Single	6H7N	Xamoterol	6H7N-β₁-Xamoterol
4.55	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.55	Single	6IIU	Ramatroban	6IIU-TXA2-Ramatroban
4.55	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
4.55	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
4.55	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
4.55	Single	7EW2	FTY720-P	7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
4.55	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
4.55	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
4.55	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-PtdIns4P-Gi1/β1/γ1
4.55	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
4.55	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
4.55	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
4.55	Single	8JJ8	Arformoterol	8JJ8-β₂-Arformoterol
4.55	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.55	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
4.55	Single	8XJN	Cloprosetnol	8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.55	Single	9AU0	BW245C	9AU0-DP₁-BW245C-Gs/β1/γ2
4.55	Single	9BJK	PubChem 171642066	9BJK-μ-Naloxone-PubChem 171642066
4.55	Single	9DGI	Z8526711350	9DGI-CB₁-Z8526711350
4.55	Single	9GGG	I-BOP	9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Single	9GL2	Befiradol	9GL2-5-HT_1A-Befiradol-Gs/β1/γ2
4.55	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
4.55	Single	9M4Q	Doxazosin	9M4Q-Alpha1A-Doxazosin
4.55	Single	9WSV	DAMGO	9WSV-μ-DAMGO-Arrestin2
4.55	Single	9YDU	UDP-Glucose	9YDU-P2Y₁₄-UDP-Glucose-Gi1/β1/γ2
4.55	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
4.55	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
4.55	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.55	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoprenaline-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.55	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
4.55	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
4.55	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.55	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
4.55	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.35	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.35	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
4.35	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
4.35	Single	5X93	K-8794	5X93-ET_B-K-8794
4.35	Single	6DDF	DAMGO	6DDF-μ-DAMGO-Gi1/β1/γ2
4.35	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.35	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.35	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
4.35	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.35	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
4.35	Single	7D7M	PGE2	7D7M-EP₄-PGE2-Gs/β1/γ1
4.35	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
4.35	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
4.35	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
4.35	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
4.35	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
4.35	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
4.35	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
4.35	Single	8GAG	Z8526711350	8GAG-CB₁-Z8526711350-Gi1/β1/γ2
4.35	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
4.35	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
4.35	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
4.35	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
4.35	Single	8S2T	Isoprenaline	8S2T-β₁-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8XGS	Kisspeptin-1	8XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
4.35	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	8ZWG	JR14a	8ZWG-C3a_B-JR14a-Gi1/β1/γ2
4.35	Single	9AS0	2-bromo-LSD	9AS0-5-HT_2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9DYE	Buspirone	9DYE-5-HT_1A-Buspirone-PtdIns4P-Go/β1/γ2
4.35	Single	9GG5	U46619	9GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	9IZF	LPA	9IZF-LPA₁-LPA-Gi1/β1/γ2
4.35	Single	9KT8	Acifran	9KT8-HCA₂-Acifran-Gi1/β1/γ2
4.35	Single	9UYH	Chemerin-9	9UYH-CML2-Chemerin-9-Arrestin2
4.35	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.35	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.35	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.35	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
4.17	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
4.17	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
4.17	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
4.17	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
4.17	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
4.17	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.17	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.17	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.17	Single	9IPV	JR14a	9IPV-C3a_B-JR14a-Gi1/β1/γ2
4.17	Single	9IPY	JR14a	9IPY-C3a_B-JR14a
4.17	Single	9IZA	SCH900271	9IZA-HCA₂-SCH900271-Gi1/β1/γ2
4.17	Single	9KZ2	EP67	9KZ2-C3a_B-EP67-Go/β1/γ2
4.17	Single	9WSX	Endomorphin	9WSX-μ-Endomorphin-Arrestin2
4.00	Single	4AMJ	Carvedilol	4AMJ-β₁-Carvedilol
4.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.00	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
4.00	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
4.00	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
4.00	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.00	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-Gi1/β1/γ1
4.00	Single	8WKY	PG-934	8WKY-MC₄-PG-934
4.00	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00	Single	9BUY	LM189	9BUY-β₂-LM189-Gi1/β1/γ2
4.00	Single	9J0I	UDP-Glucuronic acid	9J0I-P2Y₁₄-UDP-Glucuronic acid-Gi1/β1/γ2
4.00	Single	9M4T	Silodosin	9M4T-Alpha1A-Silodosin
4.00	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
4.00	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
4.00	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
4.00	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
3.85	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
3.85	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.85	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
3.85	Single	7VBI	Tirzepatide (non-acylated)	7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
3.85	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.85	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	9IQR	Muscarinic toxin 3	9IQR-α_2a-Muscarinic toxin 3
3.85	Single	9IQS	Muscarinic toxin 3	9IQS-M₄-Muscarinic toxin 3
3.85	Single	9JFK	(Pen5)-Urotensin II	9JFK-UT-(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85	Single	9UMX	EP54	9UMX-C5a₁-EP54-Go/β1/γ2
3.85	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
3.85	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
3.85	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
3.85	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
3.70	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
3.70	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
3.70	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
3.70	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.70	Single	8YFO	Ac-LA-PTH Analog	8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
3.70	Single	9B54	VIP36	9B54-CB₁-VIP36-Gi1/β1/γ2
3.70	Single	9B5Y	LA-PTH Analog	9B5Y-PTH1-LA-PTH Analog-chim(NtGi1-Gq)/β1/γ2
3.70	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
3.70	Single	9M1O	Neuropeptide-FF	9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
3.57	Single	6M1I	PACAP27	6M1I-PAC₁-PACAP27-Gs/β1/γ2
3.57	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.57	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
3.57	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.57	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
3.57	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
3.57	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
3.57	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
3.57	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
3.57	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
3.57	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
3.57	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.57	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
3.57	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.57	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
3.57	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
3.57	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
3.45	Single	5YQZ	NNC1702	5YQZ-Glucagon-NNC1702
3.45	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
3.45	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
3.45	Single	7P02	Substance-P	7P02-NK₁-Substance-P-chim(NtGi1-Gs)/β1/γ2
3.45	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
3.45	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
3.45	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Single	8IA2	C5a	8IA2-C5a₁-C5a-Go/β1/γ2
3.45	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
3.45	Single	8YG4	LA-PTH Analog	8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
3.45	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
3.45	Single	9E2A	GLP-1	9E2A-GLP-1-GLP-1-Gs/β1/γ2
3.45	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
3.45	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
3.33	Single	6FJ3	PTH	6FJ3-PTH1-PTH
3.33	Single	6NBF	LA-PTH Analog	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
3.33	Single	6NBI	LA-PTH Analog	6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
3.33	Single	6P9Y	PACAP27	6P9Y-PAC₁-PACAP27-Gs/β1/γ2
3.33	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
3.33	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
3.33	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
3.33	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
3.33	Single	7VAB	Tirzepatide (non-acylated)	7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
3.33	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.33	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
3.33	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.33	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
3.33	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
3.33	Single	9P92	VIP	9P92-PAC₁-VIP-Gs/β1/γ2
3.33	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
3.33	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
3.33	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
3.33	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
3.23	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.23	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
3.23	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.23	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.23	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
3.23	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
3.23	Single	7S1M	Exendin-4-D-Ala	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
3.23	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
3.23	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
3.23	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.23	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
3.23	Single	8FU6	ZP3780	8FU6-Glucagon-ZP3780-Gs/β1/γ2
3.23	Single	8ZH8	QRFP26	8ZH8-QRFP-QRFP26-Gq/β1/γ1
3.23	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
3.23	Single	9P94	PACAP27	9P94-PAC₁-PACAP27-Gs/β1/γ2
3.23	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.23	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
3.23	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.23	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
3.12	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
3.12	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
3.12	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
3.12	Single	6NBH	LA-PTH Analog	6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
3.12	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
3.12	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
3.12	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
3.12	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.12	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
3.12	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
3.12	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
3.12	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
3.12	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
3.12	Single	9P93	VIP	9P93-PAC₁-VIP-Gs/β1/γ2
3.12	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
3.12	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.12	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.12	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
3.12	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
3.03	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
3.03	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
3.03	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
3.03	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.03	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
3.03	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
3.03	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
3.03	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
2.94	Single	6LPB	PACAP27	6LPB-PAC₁-PACAP27-Gs/β1/γ1
2.94	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
2.94	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
2.94	Single	8FLU	LA-PTH Analog	8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
2.94	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
2.94	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.86	Single	6WPW	ZP3780	6WPW-Glucagon-ZP3780-Gs/β1/γ2
2.86	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
2.86	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.86	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.86	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.86	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
2.86	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.78	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
2.78	Single	7Y36	PTH	7Y36-PTH1-PTH-Gs/β1/γ2
2.78	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
2.78	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.78	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
2.78	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.78	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
2.78	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
2.70	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
2.70	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
2.56	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
2.56	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
2.44	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.44	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
2.33	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp

PDB Summary
PDB	4XNV
Class	A
SubFamily	Nucleotide
Type	P2Y
SubType	P2Y1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	BPTU
Protein Partners	-
PDB Resolution	2.2
Date	2015-04-01
D.O.I.	doi.org/10.1038/nature14287

Net Summary
I_min	4.36
Number of Linked Nodes	267
Number of Links	292
Number of Hubs	35
Number of Links mediated by Hubs	134
Number of Communities	9
Number of Nodes involved in Communities	45
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	94746
Length Of Smallest Path	3
Average Path Length	18.0932
Length of Longest Path	39
Minimum Path Strength	1.255
Average Path Strength	7.62024
Maximum Path Strength	21.325
Minimum Path Correlation	0.7
Average Path Correlation	0.921478
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	37.9364
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.2892
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • binding • metal ion binding • small molecule binding • A1 adenosine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • adenosine receptor binding • adenyl ribonucleotide binding • nucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • adenyl nucleotide binding • ATP binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • ADP binding • G protein-coupled purinergic nucleotide receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled ATP receptor activity • protein heterodimerization activity • protein dimerization activity • scaffold protein binding • G protein-coupled ADP receptor activity • molecular function regulator activity • signaling receptor regulator activity • catabolic process • hydrocarbon catabolic process • metabolic process • cellular process • alkane catabolic process • hydrocarbon metabolic process • multicellular organismal process • regulation of biological process • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • biological regulation • positive regulation of biological process
Gene Ontology	Biological Process	• catabolic process • hydrocarbon catabolic process • metabolic process • cellular process • alkane catabolic process • hydrocarbon metabolic process • multicellular organismal process • regulation of biological process • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • biological regulation • positive regulation of biological process • mating behavior • behavior • positive regulation of penile erection • positive regulation of multicellular organismal process • reproductive behavior • regulation of multicellular organismal process • penile erection • copulation • positive regulation of reproductive process • positive regulation of cell communication • regulation of localization • regulation of cellular process • regulation of hormone secretion • signaling • transport • positive regulation of secretion by cell • hormone secretion • cell communication • localization • positive regulation of hormone secretion • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • regulation of biological quality • positive regulation of cellular process • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • positive regulation of transport • regulation of cell communication • hormone transport • positive regulation of signaling • monoatomic ion transport • protein localization to cell periphery • cellular localization • protein localization to plasma membrane • macromolecule localization • intracellular protein localization • localization within membrane • protein localization to membrane • cellular response to stimulus • purinergic nucleotide receptor signaling pathway • response to stimulus • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • G protein-coupled adenosine receptor signaling pathway • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • signal transduction involved in regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of metabolic process • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • cellular response to ATP • response to organophosphorus • response to oxygen-containing compound • response to nitrogen compound • response to ATP • response to purine-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of inositol phosphate biosynthetic process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of inositol trisphosphate biosynthetic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • positive regulation of phosphorus metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of carbohydrate metabolic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulated exocytosis • modulation of chemical synaptic transmission • synaptic vesicle cycle • synaptic vesicle exocytosis • vesicle-mediated transport • vesicle-mediated transport in synapse • regulation of regulated secretory pathway • synaptic signaling • establishment of localization in cell • trans-synaptic signaling • neurotransmitter secretion • regulation of neurotransmitter transport • regulation of synaptic vesicle exocytosis • neurotransmitter transport • regulation of vesicle-mediated transport • chemical synaptic transmission • signal release from synapse • regulation of trans-synaptic signaling • exocytosis • regulation of neurotransmitter secretion • anterograde trans-synaptic signaling • regulation of exocytosis • regulation of monoatomic ion transport • positive regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • eating behavior • feeding behavior • G protein-coupled purinergic nucleotide receptor signaling pathway • developmental process • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • cellular response to purine-containing compound • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • response to endogenous stimulus • response to growth factor • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular developmental process • glial cell migration • nervous system development • neurogenesis • multicellular organism development • gliogenesis • cell differentiation • cell migration • cell motility • system development • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • blood circulation • regulation of anatomical structure size • monoamine transport • nitrogen compound transport • negative regulation of amine transport • regulation of catecholamine secretion • negative regulation of biological process • negative regulation of transport • organic hydroxy compound transport • negative regulation of secretion • catecholamine transport • negative regulation of cellular process • negative regulation of norepinephrine secretion • negative regulation of secretion by cell • norepinephrine transport • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • muscle system process • relaxation of muscle • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • somatodendritic compartment
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • glutamatergic synapse • cell body • membrane-bounded organelle • organelle • cilium • apical part of cell • apical plasma membrane • cell surface • presynaptic active zone membrane • presynaptic membrane • presynapse • presynaptic active zone • postsynaptic density • neuron to neuron synapse • postsynaptic specialization • asymmetric synapse
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Rubredoxin-like
SCOP2	Family Identifier	• G protein-coupled receptor-like • Rubredoxin-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BUR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	BUR
Name	1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea
Synonyms
Identifier
Formula	C23 H22 F3 N3 O3
Molecular Weight	445.434
SMILES
PubChem	11510579
Formal Charge	0
Total Atoms	54
Total Chiral Atoms	0
Total Bonds	56
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47900
Sequence	>4XNV_Chain_R S F K C A L T K T G F Q F Y Y L P A V Y I L V F I I G F L G N S V A I W M F V F H M K P W S G I S V Y M F N L A L A D F L Y V L T L P A L I F Y Y F N K T D W I F G D A M C K L Q R F I F H V N L Y G S I L F L T C I S A H R Y S G V V Y P K S L G R L K K K N A I C I S V L V W L I V V V A I S P I L F Y S G T G V R K N K T I T C Y D T T S D E Y L R S Y F I Y S M C T T V A M F C V P L V L I L G C Y G L I V R A L I Y K P L R R K S I Y L V I I V L T V F A V S Y I P F H V M K T M N L R A R L D F Q T P A M C A F N D R V Y A T Y Q V T R G L A S L N S C V N P I L Y F L A G D T F R R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4XNW	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	MRS2500	-	-	2.7	2015-04-01	doi.org/10.1038/nature14287
	7XXH	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-	chim(NtGi1-G11)/β1/γ2	2.9	2023-06-07	doi.org/10.1093/procel/pwac025
	7XXH (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-		2.9	2023-06-07	doi.org/10.1093/procel/pwac025
	8KGG	A	Nucleotide	P2Y	P2Y10	Homo sapiens	Lysophosphatidylserine (WJS)	-	chim(NtGi2-G13)/β1/γ2	3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	8KGG (No Gprot)	A	Nucleotide	P2Y	P2Y10	Homo sapiens	Lysophosphatidylserine (WJS)	-		3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	8WJX	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-	chim(Gs-CtGq)/β1/γ2	3.2	2024-10-02	To be published
	8WJX (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-		3.2	2024-10-02	To be published
	9JCL	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-	chim(Gs-CtGq)/β1/γ2	2.76	2025-09-10	To be published
	9JCL (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-		2.76	2025-09-10	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.