psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F40	R:R:P293	17.34	No	No	0	5	1
2	R:R:C42	R:R:Q291	9.16	No	No	0	8	2
3	R:R:C296	R:R:C42	7.28	No	No	0	4	8
4	R:R:L44	R:R:Y303	12.89	No	Yes	0	2	4
5	R:R:F49	R:R:K46	11.17	No	Yes	0	4	4
6	R:R:K46	R:R:Q50	16.27	Yes	Yes	2	4	4
7	R:R:K46	R:R:Y303	5.97	Yes	Yes	2	4	4
8	R:R:A304	R:R:K46	4.82	No	Yes	0	3	4
9	R:R:F51	R:R:Q50	11.71	No	Yes	0	3	4
10	R:R:Q50	R:R:Y303	10.15	Yes	Yes	2	4	4
11	R:R:Q307	R:R:Q50	8.96	No	Yes	2	5	4
12	R:R:V57	R:R:Y53	6.31	No	Yes	0	4	5
13	R:R:L54	R:R:Y58	10.55	Yes	Yes	0	6	7
14	R:R:L54	R:R:Y111	5.86	Yes	No	0	6	5
15	R:R:L54	R:R:R310	4.86	Yes	Yes	0	6	5
16	R:R:P55	R:R:Y111	11.13	No	No	0	6	5
17	R:R:L104	R:R:Y58	4.69	No	Yes	0	7	7
18	R:R:L107	R:R:Y58	9.38	No	Yes	0	7	7
19	R:R:S314	R:R:Y58	5.09	No	Yes	0	7	7
20	R:R:I108	R:R:I59	5.89	No	No	5	7	5
21	R:R:F62	R:R:F66	5.36	No	Yes	1	6	5
22	R:R:F62	R:R:P105	13	No	No	1	6	9
23	R:R:F62	W:W:?1	12.87	No	Yes	1	6	0
24	R:R:C318	R:R:I64	6.55	No	No	0	7	5
25	R:R:F66	R:R:S70	7.93	Yes	No	1	5	3
26	R:R:F66	R:R:F98	6.43	Yes	Yes	1	5	7
27	R:R:F66	W:W:?1	12.11	Yes	Yes	1	5	0
28	R:R:D97	R:R:N69	5.39	Yes	No	0	9	9
29	R:R:N69	R:R:P321	8.15	No	No	0	9	9
30	R:R:F98	R:R:S70	5.28	Yes	No	1	7	3
31	R:R:F98	R:R:I73	5.02	Yes	No	0	7	7
32	R:R:H79	R:R:W74	5.29	No	No	0	5	3
33	R:R:F331	R:R:M75	12.44	Yes	No	0	8	7
34	R:R:F76	R:R:S87	5.28	Yes	No	0	6	7
35	R:R:F76	R:R:F91	6.43	Yes	No	0	6	5
36	R:R:F76	R:R:Y324	7.22	Yes	Yes	0	6	9
37	R:R:F331	R:R:F76	12.86	Yes	Yes	0	8	6
38	R:R:F78	R:R:V77	11.8	No	No	0	5	3
39	R:R:M80	R:R:W83	5.82	Yes	No	0	5	6
40	R:R:M80	R:R:S87	4.6	Yes	No	0	5	7
41	R:R:F331	R:R:M80	7.46	Yes	Yes	0	8	5
42	R:R:M80	R:R:R332	6.2	Yes	No	0	5	8
43	R:R:K81	R:R:R333	14.85	No	No	0	6	5
44	R:R:P82	R:R:R332	5.76	No	No	0	5	8
45	R:R:F91	R:R:W83	15.03	No	No	0	5	6
46	R:R:S84	R:R:S87	6.52	No	No	0	7	7
47	R:R:D329	R:R:S84	7.36	No	No	0	5	7
48	R:R:G85	R:R:H148	4.77	No	Yes	0	6	8
49	R:R:H148	R:R:I86	5.3	Yes	No	0	8	7
50	R:R:I86	R:R:R149	6.26	No	Yes	0	7	9
51	R:R:D329	R:R:I86	9.8	No	No	0	5	7
52	R:R:A168	R:R:V88	5.09	No	No	0	8	6
53	R:R:I169	R:R:V88	6.14	No	No	0	4	6
54	R:R:C144	R:R:Y89	13.44	No	Yes	0	6	7
55	R:R:I145	R:R:Y89	4.84	No	Yes	0	8	7
56	R:R:H148	R:R:Y89	4.36	Yes	Yes	0	8	7
57	R:R:A168	R:R:Y89	6.67	No	Yes	0	8	7
58	R:R:I171	R:R:Y89	8.46	No	Yes	0	5	7
59	R:R:I145	R:R:M90	4.37	No	No	0	8	8
60	R:R:M90	R:R:Y324	5.99	No	Yes	0	8	9
61	R:R:F91	R:R:L95	4.87	No	No	0	5	5
62	R:R:F141	R:R:N92	10.87	Yes	No	4	7	9
63	R:R:N92	R:R:S172	7.45	No	No	4	9	7
64	R:R:N92	R:R:W176	7.91	No	No	4	9	9
65	R:R:L93	R:R:N320	9.61	No	No	0	9	9
66	R:R:L93	R:R:Y324	10.55	No	Yes	0	9	9
67	R:R:D97	R:R:N134	6.73	Yes	Yes	3	9	8
68	R:R:D97	R:R:S138	4.42	Yes	No	3	9	9
69	R:R:D97	R:R:S317	8.83	Yes	Yes	3	9	9
70	R:R:D97	R:R:N320	6.73	Yes	No	0	9	9
71	R:R:F98	R:R:L102	8.53	Yes	No	0	7	5
72	R:R:I130	R:R:L99	8.56	No	No	0	4	7
73	R:R:L104	R:R:Y100	8.21	No	Yes	0	7	7
74	R:R:F131	R:R:Y100	8.25	No	Yes	0	7	7
75	R:R:N134	R:R:Y100	10.47	Yes	Yes	3	8	7
76	R:R:S314	R:R:Y100	5.09	No	Yes	0	7	7
77	R:R:S317	R:R:Y100	6.36	Yes	Yes	3	9	7
78	R:R:L102	W:W:?1	5.16	No	Yes	0	5	0
79	R:R:Q127	R:R:T103	8.5	Yes	No	1	4	6
80	R:R:I130	R:R:T103	4.56	No	No	0	4	6
81	R:R:T103	W:W:?1	13.74	No	Yes	1	6	0
82	R:R:P105	W:W:?1	17.35	No	Yes	1	9	0
83	R:R:A106	W:W:?1	7.83	No	Yes	0	6	0
84	R:R:L107	R:R:Q127	11.98	No	Yes	0	7	4
85	R:R:F109	R:R:N113	6.04	No	No	0	3	4
86	R:R:F109	R:R:I118	7.54	No	No	1	3	3
87	R:R:F109	R:R:F119	6.43	No	Yes	1	3	7
88	R:R:T115	R:R:Y110	8.74	No	No	0	4	5
89	R:R:W117	R:R:Y110	8.68	Yes	No	0	8	5
90	R:R:D116	R:R:N113	5.39	No	No	0	5	4
91	R:R:R195	R:R:T115	5.17	Yes	No	0	1	4
92	R:R:D116	R:R:T199	10.12	No	No	0	5	4
93	R:R:F119	R:R:W117	12.03	Yes	Yes	1	7	8
94	R:R:C124	R:R:W117	6.53	No	Yes	1	9	8
95	R:R:Q127	R:R:W117	7.67	Yes	Yes	1	4	8
96	R:R:T192	R:R:W117	4.85	No	Yes	0	5	8
97	R:R:C202	R:R:W117	13.06	No	Yes	1	9	8
98	R:R:F119	R:R:I118	10.05	Yes	No	1	7	3
99	R:R:F119	W:W:?1	7.57	Yes	Yes	1	7	0
100	R:R:D121	R:R:K125	8.3	No	No	0	3	7
101	R:R:D121	R:R:T192	5.78	No	No	0	3	5
102	R:R:M123	W:W:?1	10.54	No	Yes	0	5	0
103	R:R:C124	R:R:C202	7.28	No	No	1	9	9
104	R:R:I130	R:R:L126	7.14	No	No	0	4	4
105	R:R:Q127	W:W:?1	5.79	Yes	Yes	1	4	0
106	R:R:R128	R:R:S190	5.27	No	No	0	5	5
107	R:R:C202	R:R:R128	8.36	No	No	0	9	5
108	R:R:D204	R:R:R128	8.34	No	No	0	6	5
109	R:R:F129	R:R:V133	7.87	Yes	No	0	6	5
110	R:R:F129	R:R:L187	14.61	Yes	No	0	6	5
111	R:R:F131	R:R:H132	10.18	No	No	0	7	5
112	R:R:F131	R:R:F276	6.43	No	No	0	7	7
113	R:R:H132	R:R:I186	13.26	No	No	0	5	4
114	R:R:V133	R:R:V179	4.81	No	No	0	5	7
115	R:R:N134	R:R:S138	4.47	Yes	No	3	8	9
116	R:R:N134	R:R:S317	4.47	Yes	Yes	3	8	9
117	R:R:L135	R:R:Y136	14.07	No	Yes	7	7	7
118	R:R:H277	R:R:L135	5.14	Yes	No	7	8	7
119	R:R:I183	R:R:Y136	4.84	No	Yes	0	7	7
120	R:R:M225	R:R:Y136	10.78	No	Yes	0	5	7
121	R:R:H277	R:R:Y136	8.71	Yes	Yes	7	8	7
122	R:R:I139	R:R:Y273	8.46	No	No	0	7	8
123	R:R:L140	R:R:V175	4.47	No	No	0	5	7
124	R:R:F141	R:R:S172	6.61	Yes	No	4	7	7
125	R:R:F141	R:R:V175	11.8	Yes	No	0	7	7
126	R:R:F141	R:R:W176	9.02	Yes	No	4	7	9
127	R:R:P229	R:R:T143	6.99	No	No	0	9	8
128	R:R:L232	R:R:T143	4.42	No	No	0	6	8
129	R:R:I233	R:R:T143	7.6	No	No	0	8	8
130	R:R:I233	R:R:S146	6.19	No	No	8	8	9
131	R:R:S146	R:R:Y237	10.17	No	Yes	8	9	9
132	R:R:H148	R:R:K164	5.24	Yes	No	0	8	6
133	R:R:L254	R:R:R149	4.86	No	Yes	0	4	9
134	R:R:K257	R:R:R149	6.19	No	Yes	0	8	9
135	R:R:R149	R:R:S258	5.27	Yes	No	0	9	7
136	R:R:V154	R:R:Y150	6.31	No	Yes	9	7	7
137	R:R:Y150	R:R:Y155	4.96	Yes	No	9	7	6
138	R:R:C236	R:R:Y150	5.38	No	Yes	0	6	7
139	R:R:L239	R:R:Y150	8.21	No	Yes	0	4	7
140	R:R:L254	R:R:V153	4.47	No	No	0	4	8
141	R:R:V154	R:R:Y155	7.57	No	No	9	7	6
142	R:R:K158	R:R:L160	5.64	No	No	0	5	5
143	R:R:L160	R:R:L163	9.69	No	No	0	5	8
144	R:R:P185	R:R:S184	5.34	No	No	0	8	4
145	R:R:P185	R:R:Y217	16.69	No	Yes	0	8	5
146	R:R:I186	R:R:Y217	7.25	No	Yes	0	4	5
147	R:R:F188	R:R:Y189	7.22	No	Yes	0	4	4
148	R:R:F188	R:R:Y210	12.38	No	No	0	4	4
149	R:R:T206	R:R:Y189	7.49	No	Yes	0	5	4
150	R:R:S213	R:R:Y189	7.63	No	Yes	0	1	4
151	R:R:Y189	R:R:Y214	14.89	Yes	Yes	0	4	4
152	R:R:Y189	R:R:Y217	8.94	Yes	Yes	0	4	5
153	R:R:K198	R:R:V194	4.55	No	No	0	2	2
154	R:R:N197	R:R:R195	4.82	No	Yes	6	4	1
155	R:R:R195	R:R:T199	9.06	Yes	No	6	1	4
156	R:R:R195	R:R:T201	15.52	Yes	No	0	1	3
157	R:R:N197	R:R:T199	8.77	No	No	6	4	4
158	R:R:D204	R:R:Y306	4.6	No	No	2	6	4
159	R:R:D204	R:R:R310	16.68	No	Yes	2	6	5
160	R:R:T205	R:R:Y214	6.24	No	Yes	0	5	4
161	R:R:R287	R:R:T205	6.47	No	No	0	5	5
162	R:R:S207	R:R:Y210	5.09	No	No	0	5	4
163	R:R:E209	R:R:Y210	17.96	No	No	0	3	4
164	R:R:L211	R:R:R287	10.93	No	No	0	4	5
165	R:R:L211	R:R:L288	8.3	No	No	0	4	3
166	R:R:L288	R:R:R212	15.79	No	No	0	3	1
167	R:R:D289	R:R:R212	8.34	No	No	0	1	1
168	R:R:S218	R:R:Y214	8.9	No	Yes	0	5	4
169	R:R:L284	R:R:Y214	4.69	No	Yes	0	4	4
170	R:R:F215	R:R:M219	7.46	No	No	0	4	4
171	R:R:F215	R:R:L284	6.09	No	No	0	4	4
172	R:R:T221	R:R:Y217	4.99	No	Yes	0	5	5
173	R:R:K280	R:R:S218	6.12	No	No	0	6	5
174	R:R:M219	R:R:T281	4.52	No	No	0	4	5
175	R:R:H277	R:R:T222	8.21	Yes	No	0	8	5
176	R:R:F226	R:R:H277	33.94	Yes	Yes	0	8	8
177	R:R:F269	R:R:L230	8.53	No	No	0	9	6
178	R:R:I233	R:R:Y237	7.25	No	Yes	8	8	9
179	R:R:L261	R:R:Y237	8.21	No	Yes	0	7	9
180	R:R:V262	R:R:Y237	16.4	No	Yes	0	7	9
181	R:R:V265	R:R:Y237	8.83	No	Yes	0	7	9
182	R:R:L266	R:R:Y237	4.69	No	Yes	0	7	9
183	R:R:R242	R:R:Y246	5.14	No	No	0	5	5
184	R:R:L244	R:R:R255	9.72	No	No	0	8	6
185	R:R:K247	R:R:R255	4.95	No	No	0	4	6
186	R:R:D329	R:R:K257	5.53	No	No	0	5	8
187	R:R:L326	R:R:Y260	12.89	No	No	0	6	6
188	R:R:I264	R:R:L323	5.71	No	No	0	4	7
189	R:R:N316	R:R:V268	4.43	No	No	0	9	6
190	R:R:F269	R:R:Y273	14.44	No	No	0	9	8
191	R:R:N316	R:R:S272	8.94	No	No	0	9	8
192	R:R:N316	R:R:Y273	17.44	No	No	0	9	8
193	R:R:A313	R:R:F276	6.93	No	No	0	7	7
194	R:R:M279	R:R:M282	5.78	No	No	0	5	5
195	R:R:M279	R:R:T305	6.02	No	No	0	5	4
196	R:R:M279	R:R:T309	7.53	No	No	0	5	7
197	R:R:M282	R:R:V302	4.56	No	No	0	5	4
198	R:R:N283	R:R:Y303	5.81	No	Yes	0	4	4
199	R:R:N283	R:R:Y306	11.63	No	No	0	4	4
200	R:R:D289	R:R:R285	7.15	No	No	0	1	4
201	R:R:F290	R:R:R285	10.69	No	No	0	3	4
202	R:R:A286	R:R:N299	6.25	No	No	0	1	2
203	R:R:F290	R:R:M295	9.95	No	Yes	0	3	4
204	R:R:F298	R:R:M295	4.98	No	Yes	0	1	4
205	R:R:M295	R:R:N299	5.61	Yes	No	0	4	2
206	R:R:F298	R:R:V302	7.87	No	No	0	1	4
207	R:R:Q307	R:R:Y303	16.91	No	Yes	2	5	4
208	R:R:R310	R:R:Y306	14.4	Yes	No	2	5	4
209	R:R:Q307	R:R:R310	9.35	No	Yes	2	5	5
210	R:R:F325	R:R:F331	5.36	No	Yes	0	6	8
211	R:R:G311	R:R:Y53	4.35	No	Yes	0	4	5
212	R:R:G193	R:R:Y203	4.35	No	No	0	2	4
213	R:R:F226	R:R:F269	4.29	Yes	No	0	8	9
214	R:R:I145	R:R:L261	4.28	No	No	0	8	7
215	R:R:D116	R:R:I200	4.2	No	No	0	5	4
216	R:R:L142	R:R:L93	4.15	No	No	0	8	9
217	R:R:L230	R:R:L234	4.15	No	No	0	6	4
218	R:R:L261	R:R:L323	4.15	No	No	0	7	7
219	R:R:G68	R:R:P321	4.06	No	No	0	6	9
220	R:R:A94	R:R:Y324	4	No	Yes	0	9	9
221	R:R:H132	R:R:I183	3.98	No	No	0	5	7
222	R:R:H79	R:R:M75	3.94	No	No	0	5	7
223	R:R:C124	R:R:G191	3.92	No	No	0	9	4
224	R:R:F129	R:R:I183	3.77	Yes	No	0	6	7
225	R:R:F226	R:R:I274	3.77	Yes	No	0	8	5
226	R:R:G137	R:R:V179	3.68	No	No	0	6	7
227	R:R:P229	R:R:V228	3.53	No	No	0	9	6
228	R:R:L54	R:R:Y53	3.52	Yes	Yes	0	6	5
229	R:R:P275	R:R:T309	3.5	No	No	0	9	7
230	R:R:G328	R:R:M90	3.49	No	No	0	8	8
231	R:R:L140	R:R:P229	3.28	No	No	0	5	9
232	R:R:S314	R:R:V61	3.23	No	No	0	7	6
233	R:R:S317	R:R:V101	3.23	Yes	No	0	9	5
234	R:R:S272	R:R:V271	3.23	No	No	0	8	6
235	R:R:A182	R:R:M225	3.22	No	No	0	4	5
236	R:R:C170	R:R:L174	3.17	No	No	0	3	3
237	R:R:A327	R:R:L323	3.15	No	No	0	6	7
238	R:R:I240	R:R:S258	3.1	No	No	0	7	7
239	R:R:R256	R:R:Y260	3.09	No	No	0	5	6
240	R:R:M282	R:R:V278	3.04	No	No	0	5	6
241	R:R:F78	R:R:W74	3.01	No	No	0	5	3
242	R:R:M295	R:R:T292	3.01	Yes	No	0	4	2
243	R:R:L315	R:R:V61	2.98	No	No	0	5	6
244	R:R:L177	R:R:V173	2.98	No	No	0	4	4
245	R:R:L312	R:R:V308	2.98	No	No	0	7	5
246	R:R:I59	R:R:I63	2.94	No	No	0	5	5
247	R:R:I259	R:R:I263	2.94	No	No	0	6	4
248	R:R:I169	R:R:K165	2.91	No	No	0	4	3
249	R:R:G48	R:R:Y52	2.9	No	No	0	4	3
250	R:R:F112	R:R:P55	2.89	No	No	0	4	6
251	R:R:I64	R:R:L60	2.85	No	No	0	5	5
252	R:R:I322	R:R:L326	2.85	No	No	0	6	6
253	R:R:G120	R:R:W117	2.81	No	Yes	0	6	8
254	R:R:C296	R:R:F40	2.79	No	No	0	4	5
255	R:R:C227	R:R:F226	2.79	No	Yes	0	4	8
256	R:R:D208	R:R:K41	2.77	No	No	0	3	1
257	R:R:K41	R:R:Q291	2.71	No	No	0	1	2
258	R:R:A72	R:R:Y324	2.67	No	Yes	0	8	9
259	R:R:N299	R:R:Q291	2.64	No	No	0	2	2
260	R:R:F129	R:R:V180	2.62	Yes	No	0	6	4
261	R:R:F51	R:R:T47	2.59	No	No	0	3	2
262	R:R:A96	R:R:W176	2.59	No	No	0	8	9
263	R:R:V308	R:R:Y53	2.52	No	Yes	0	5	5
264	R:R:F112	R:R:I59	2.51	No	No	5	4	5
265	R:R:F112	R:R:I108	2.51	No	No	5	4	7
266	R:R:I240	R:R:Y150	2.42	No	Yes	0	7	7
267	R:R:C318	R:R:G65	1.96	No	No	0	7	8
268	R:R:G65	R:R:V101	1.84	No	No	0	8	5
269	R:R:G193	R:R:T192	1.82	No	No	0	2	5
270	R:R:A147	R:R:C236	1.81	No	No	0	6	6
271	R:R:G68	R:R:L67	1.71	No	No	0	6	4
272	R:R:A243	R:R:V153	1.7	No	No	0	5	8
273	R:R:A243	R:R:V154	1.7	No	No	0	5	7
274	R:R:V241	R:R:V262	1.6	No	No	0	5	7
275	R:R:V268	R:R:V319	1.6	No	No	0	6	5
276	R:R:T267	R:R:V271	1.59	No	No	0	4	6
277	R:R:I245	R:R:V241	1.54	No	No	0	3	5
278	R:R:M75	R:R:V71	1.52	No	No	0	7	5
279	R:R:I263	R:R:T267	1.52	No	No	0	4	4
280	R:R:F49	R:R:G48	1.51	No	No	0	4	4
281	R:R:L244	R:R:S258	1.5	No	No	0	8	7
282	R:R:I264	R:R:I322	1.47	No	No	0	4	6
283	R:R:I178	R:R:M225	1.46	No	No	0	5	5
284	R:R:P82	R:R:R334	1.44	No	No	0	5	5
285	R:R:P253	R:R:R256	1.44	No	No	0	4	5
286	R:R:I178	R:R:L174	1.43	No	No	0	5	3
287	R:R:I171	R:R:N167	1.42	No	No	0	5	4
288	R:R:K164	R:R:L160	1.41	No	No	0	6	5
289	R:R:S151	R:R:Y150	1.27	No	Yes	0	5	7
290	R:R:I245	R:R:Y246	1.21	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:K46	9.5575	4	2	4
2	R:R:Q50	11.7725	4	2	4
3	R:R:Y53	4.175	4	0	5
4	R:R:L54	6.1975	4	0	6
5	R:R:Y58	7.4275	4	0	7
6	R:R:F66	7.9575	4	1	5
7	R:R:F76	7.9475	4	0	6
8	R:R:M80	6.02	4	0	5
9	R:R:Y89	7.554	5	0	7
10	R:R:D97	6.42	5	3	9
11	R:R:F98	6.315	4	1	7
12	R:R:Y100	7.676	5	3	7
13	R:R:W117	7.94714	7	1	8
14	R:R:F119	9.02	4	1	7
15	R:R:Q127	8.485	4	1	4
16	R:R:F129	7.2175	4	0	6
17	R:R:N134	6.535	4	3	8
18	R:R:Y136	9.6	4	7	7
19	R:R:F141	9.575	4	4	7
20	R:R:H148	4.9175	4	0	8
21	R:R:R149	5.645	4	0	9
22	R:R:Y150	4.75833	6	9	7
23	R:R:Y189	9.234	5	0	4
24	R:R:R195	8.6425	4	6	1
25	R:R:Y214	8.68	4	0	4
26	R:R:Y217	9.4675	4	0	5
27	R:R:F226	11.1975	4	0	8
28	R:R:Y237	9.25833	6	8	9
29	R:R:H277	14	4	7	8
30	R:R:M295	5.8875	4	0	4
31	R:R:Y303	10.346	5	2	4
32	R:R:R310	11.3225	4	2	5
33	R:R:S317	5.7225	4	3	9
34	R:R:Y324	6.086	5	0	9
35	R:R:F331	9.53	4	0	8
36	W:W:?1	10.3289	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F290	R:R:M295	14.6592	9.95	No	Yes	0	3	4
2	R:R:F290	R:R:R285	15.4005	10.69	No	No	0	3	4
3	R:R:D289	R:R:R285	16.1388	7.15	No	No	0	1	4
4	R:R:D289	R:R:R212	16.8725	8.34	No	No	0	1	1
5	R:R:L288	R:R:R212	17.6047	15.79	No	No	0	3	1
6	R:R:L211	R:R:L288	18.3339	8.3	No	No	0	4	3
7	R:R:L211	R:R:R287	19.06	10.93	No	No	0	4	5
8	R:R:R287	R:R:T205	19.7178	6.47	No	No	0	5	5
9	R:R:T205	R:R:Y214	20.4393	6.24	No	Yes	0	5	4
10	R:R:Y189	R:R:Y214	25.3277	14.89	Yes	Yes	0	4	4
11	R:R:Y189	R:R:Y217	30.1296	8.94	Yes	Yes	0	4	5
12	R:R:I186	R:R:Y217	32.7424	7.25	No	Yes	0	4	5
13	R:R:H132	R:R:I186	33.4078	13.26	No	No	0	5	4
14	R:R:F131	R:R:H132	53.56	10.18	No	No	0	7	5
15	R:R:F131	R:R:Y100	55.2279	8.25	No	Yes	0	7	7
16	R:R:L104	R:R:Y100	44.5108	8.21	No	Yes	0	7	7
17	R:R:L104	R:R:Y58	44.0854	4.69	No	Yes	0	7	7
18	R:R:L54	R:R:Y58	38.2218	10.55	Yes	Yes	0	6	7
19	R:R:L54	R:R:R310	24.7186	4.86	Yes	Yes	0	6	5
20	R:R:Q307	R:R:R310	18.6316	9.35	No	Yes	2	5	5
21	R:R:S314	R:R:Y100	45.6516	5.09	No	Yes	0	7	7
22	R:R:S314	R:R:Y58	44.3756	5.09	No	Yes	0	7	7
23	R:R:L107	R:R:Y58	51.8951	9.38	No	Yes	0	7	7
24	R:R:L107	R:R:Q127	50.8135	11.98	No	Yes	0	7	4
25	R:R:Q127	W:W:?1	20.7963	5.79	Yes	Yes	1	4	0
26	R:R:S317	R:R:Y100	52.8764	6.36	Yes	Yes	3	9	7
27	R:R:D97	R:R:N134	50.812	6.73	Yes	Yes	3	9	8
28	R:R:N134	R:R:Y100	51.3634	10.47	Yes	Yes	3	8	7
29	R:R:D97	R:R:S317	51.8465	8.83	Yes	Yes	3	9	9
30	R:R:D97	R:R:N320	100	6.73	Yes	No	0	9	9
31	R:R:L93	R:R:N320	99.4197	9.61	No	No	0	9	9
32	R:R:L93	R:R:Y324	98.2394	10.55	No	Yes	0	9	9
33	R:R:F76	R:R:Y324	47.511	7.22	Yes	Yes	0	6	9
34	R:R:F331	R:R:F76	10.822	12.86	Yes	Yes	0	8	6
35	R:R:F76	R:R:S87	34.6944	5.28	Yes	No	0	6	7
36	R:R:S84	R:R:S87	31.4223	6.52	No	No	0	7	7
37	R:R:D329	R:R:S84	30.6689	7.36	No	No	0	5	7
38	R:R:M90	R:R:Y324	51.8966	5.99	No	Yes	0	8	9
39	R:R:I145	R:R:M90	50.4367	4.37	No	No	0	8	8
40	R:R:I145	R:R:Y89	26.9137	4.84	No	Yes	0	8	7
41	R:R:H148	R:R:Y89	20.3649	4.36	Yes	Yes	0	8	7
42	R:R:D329	R:R:I86	15.2683	9.8	No	No	0	5	7
43	R:R:H148	R:R:I86	15.8517	5.3	Yes	No	0	8	7
44	R:R:I86	R:R:R149	28.6257	6.26	No	Yes	0	7	9
45	R:R:D329	R:R:K257	14.7959	5.53	No	No	0	5	8
46	R:R:K257	R:R:R149	14.0607	6.19	No	Yes	0	8	9
47	R:R:I233	R:R:Y237	10.8448	7.25	No	Yes	8	8	9
48	R:R:L261	R:R:Y237	18.5329	8.21	No	Yes	0	7	9
49	R:R:I145	R:R:L261	26.0448	4.28	No	No	0	8	7
50	R:R:Q127	R:R:W117	25.1363	7.67	Yes	Yes	1	4	8
51	R:R:H132	R:R:I183	24.0608	3.98	No	No	0	5	7
52	R:R:I183	R:R:Y136	19.063	4.84	No	Yes	0	7	7
53	R:R:H277	R:R:Y136	13.889	8.71	Yes	Yes	7	8	7
54	R:R:F226	R:R:H277	12.4185	33.94	Yes	Yes	0	8	8
55	R:R:F226	R:R:F269	10.149	4.29	Yes	No	0	8	9
56	R:R:L254	R:R:R149	10.0837	4.86	No	Yes	0	4	9
57	R:R:R149	R:R:S258	30.1964	5.27	Yes	No	0	9	7
58	R:R:I240	R:R:S258	20.1765	3.1	No	No	0	7	7
59	R:R:I240	R:R:Y150	17.667	2.42	No	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F62	R:R:F66	5.36	1	No	Yes	6	5	1	1
R:R:F62	R:R:P105	13	1	No	No	6	9	1	1
R:R:F62	W:W:?1	12.87	1	No	Yes	6	0	1	0
R:R:F66	R:R:S70	7.93	1	Yes	No	5	3	1	2
R:R:F66	R:R:F98	6.43	1	Yes	Yes	5	7	1	2
R:R:F66	W:W:?1	12.11	1	Yes	Yes	5	0	1	0
R:R:F98	R:R:S70	5.28	1	Yes	No	7	3	2	2
R:R:F98	R:R:L102	8.53	1	Yes	No	7	5	2	1
R:R:L102	W:W:?1	5.16	0	No	Yes	5	0	1	0
R:R:Q127	R:R:T103	8.5	1	Yes	No	4	6	1	1
R:R:I130	R:R:T103	4.56	0	No	No	4	6	2	1
R:R:T103	W:W:?1	13.74	1	No	Yes	6	0	1	0
R:R:P105	W:W:?1	17.35	1	No	Yes	9	0	1	0
R:R:A106	W:W:?1	7.83	0	No	Yes	6	0	1	0
R:R:L107	R:R:Q127	11.98	0	No	Yes	7	4	2	1
R:R:F109	R:R:I118	7.54	1	No	No	3	3	2	2
R:R:F109	R:R:F119	6.43	1	No	Yes	3	7	2	1
R:R:F119	R:R:W117	12.03	1	Yes	Yes	7	8	1	2
R:R:Q127	R:R:W117	7.67	1	Yes	Yes	4	8	1	2
R:R:F119	R:R:I118	10.05	1	Yes	No	7	3	1	2
R:R:F119	W:W:?1	7.57	1	Yes	Yes	7	0	1	0
R:R:M123	W:W:?1	10.54	0	No	Yes	5	0	1	0
R:R:Q127	W:W:?1	5.79	1	Yes	Yes	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
12.50	Single	7WV9	ZCZ011	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
12.50	Consensus	cb1_on_allo	Other Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
11.11	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
11.11	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
10.00	Single	4DJH	JDTic	4DJH-κ-JDTic
10.00	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
9.52	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
9.09	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
9.09	Single	8W8R	AA-14	8W8R-GPR101-AA-14-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
8.00	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
7.69	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
7.69	Consensus	gabab_off	Other Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
7.41	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
7.14	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.14	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
6.90	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
6.67	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
6.67	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
6.67	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
6.67	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
6.67	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
6.67	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
6.67	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.45	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
6.45	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.45	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
6.45	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
6.25	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
6.25	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
6.25	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
6.25	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
6.25	Single	7FEE	ZCZ011	7FEE-CB₁-PubMed 104895-ZCZ011
6.25	Single	7XKF	Betahydroxyandrosterone	7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
6.25	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.06	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
5.88	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
5.88	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
5.88	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
5.88	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
5.88	Single	6OBA	(S)-Alprenolol	6OBA-β₂-(S)-Alprenolol-GTPL11074
5.88	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
5.88	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
5.88	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
5.88	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.88	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
5.88	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
5.88	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
5.88	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
5.88	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
5.88	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
5.88	Consensus	alpha2a_off	Orthosteric Ligand	6KUX-α_2a-RS-79948
5.88	Consensus	beta2_off_allo	Orthosteric Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
5.88	Consensus	opsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.88	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.71	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
5.56	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
5.56	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
5.56	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
5.56	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
5.56	Single	6TPK	Retosiban	6TPK-OT-Retosiban
5.56	Single	6VI4	JDTic	6VI4-κ-JDTic
5.56	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	7UM7	Methylergometrine	7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
5.56	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.56	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
5.56	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
5.56	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
5.56	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.56	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
5.56	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
5.56	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
5.56	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
5.56	Consensus	sensory_off	Orthosteric Ligand	opsin_off
5.56	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
5.41	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
5.26	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
5.26	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.26	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
5.26	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
5.26	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
5.26	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
5.26	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol
5.26	Single	6IIV	Daltroban	6IIV-TP-Daltroban
5.26	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
5.26	Single	7BU7	BI167107	7BU7-β₁-BI167107
5.26	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
5.26	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
5.26	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
5.26	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
5.26	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
5.26	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
5.26	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
5.26	Single	8UO4	Epinephrine	8UO4-β₂-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
5.26	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
5.26	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
5.26	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
5.26	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
5.26	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
5.13	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.00	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
5.00	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
5.00	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
5.00	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
5.00	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
5.00	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
5.00	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
5.00	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
5.00	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
5.00	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
5.00	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
5.00	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
5.00	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
5.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.00	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
5.00	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
5.00	Single	7C4S	S1P	7C4S-S1P₃-S1P
5.00	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
5.00	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
5.00	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
5.00	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
5.00	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
5.00	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.00	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.00	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
5.00	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
5.00	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.00	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.00	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
5.00	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
5.00	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
5.00	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
5.00	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
5.00	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
5.00	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
5.00	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
5.00	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
5.00	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
5.00	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
5.00	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
5.00	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
5.00	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
5.00	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
5.00	Consensus	gs_adrenergic	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2 7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2 7XJI-β₃-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
4.88	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
4.76	Single	3P0G	BI167107	3P0G-β₂-BI167107
4.76	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
4.76	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
4.76	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
4.76	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
4.76	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
4.76	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
4.76	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
4.76	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
4.76	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
4.76	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.76	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
4.76	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
4.76	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
4.76	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
4.76	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
4.76	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
4.76	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
4.76	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
4.76	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
4.76	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
4.76	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
4.76	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.76	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
4.76	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
4.76	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
4.76	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
4.76	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
4.76	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
4.76	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
4.76	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
4.76	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
4.76	Consensus	mglu2_on	Other Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.76	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
4.55	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.55	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.55	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.55	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.55	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.55	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
4.55	Single	6H7N	(S)-Xamoterol	6H7N-β₁-(S)-Xamoterol
4.55	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.55	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.55	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.55	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
4.55	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
4.55	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
4.55	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.55	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
4.55	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
4.55	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
4.55	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
4.55	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
4.55	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.55	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
4.55	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
4.55	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
4.55	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
4.55	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
4.55	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
4.55	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
4.55	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.55	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
4.55	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
4.55	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.35	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.35	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
4.35	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
4.35	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
4.35	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.35	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.35	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
4.35	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
4.35	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
4.35	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.35	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.35	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
4.35	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
4.35	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
4.35	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/&β;1/&γ;2
4.35	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
4.35	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
4.35	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
4.35	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
4.35	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
4.35	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
4.35	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.35	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
4.17	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
4.17	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.17	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
4.17	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
4.17	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.17	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
4.17	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
4.17	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
4.17	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
4.17	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
4.00	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
4.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
4.00	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
4.00	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
4.00	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
4.00	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
4.00	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
4.00	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
4.00	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
4.00	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
3.85	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.85	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.85	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.85	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
3.85	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
3.85	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
3.85	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
3.85	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
3.85	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
3.85	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
3.70	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
3.70	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
3.70	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
3.70	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
3.70	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
3.57	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
3.57	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.57	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
3.57	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.57	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
3.57	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
3.57	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
3.57	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
3.57	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.45	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
3.45	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.45	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.45	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
3.45	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
3.45	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Single	6FJ3	PTH	6FJ3-PTH1-PTH
3.33	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.33	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.33	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
3.33	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
3.33	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.33	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
3.33	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.33	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
3.33	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.33	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.33	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
3.33	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
3.23	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.23	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.23	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.23	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.23	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.23	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
3.23	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.23	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
3.23	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.23	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
3.23	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.23	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.12	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
3.12	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
3.12	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
3.12	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.12	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.12	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
3.12	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.12	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.12	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
3.12	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
3.12	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
3.12	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
3.12	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
3.12	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
3.12	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
3.12	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.03	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.03	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.03	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.03	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.03	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.03	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.03	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.94	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
2.94	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.94	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.94	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
2.94	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.94	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
2.94	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.94	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
2.86	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.86	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.86	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.86	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
2.86	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.86	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
2.78	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.78	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
2.78	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
2.78	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.78	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.78	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.78	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
2.78	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.78	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.70	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.70	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
2.70	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
2.63	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.56	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.56	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
2.56	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.50	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.50	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
2.44	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
2.44	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf

PDB Summary
PDB	4XNV
Class	A
SubFamily	Nucleotide
Type	P2Y
SubType	P2Y1
Species	Homo sapiens
Ligand	-
Other Ligand(s)	BPTU
Protein Partners	-
PDB Resolution	2.2
Date	2015-04-01
D.O.I.	10.1038/nature14287

Net Summary
I_min	4.36
Number of Linked Nodes	264
Number of Links	290
Number of Hubs	36
Number of Links mediated by Hubs	137
Number of Communities	9
Number of Nodes involved in Communities	45
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	95942
Length Of Smallest Path	3
Average Path Length	17.9853
Length of Longest Path	39
Minimum Path Strength	1.375
Average Path Strength	7.63784
Maximum Path Strength	21.325
Minimum Path Correlation	0.7
Average Path Correlation	0.921948
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	38.5414
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.9381
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	BUR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	BUR
Name	1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea
Synonyms
Identifier	1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethyloxy)phenyl]urea
Formula	C23 H22 F3 N3 O3
Molecular Weight	445.434
SMILES	CC(C)(C)c1ccccc1Oc2c(cccn2)NC(=O)Nc3ccc(cc3)OC(F)(F)F
PubChem	11510579
Formal Charge	0
Total Atoms	54
Total Chiral Atoms	0
Total Bonds	56
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47900
Sequence	>4XNV_Chain_R S F K C A L T K T G F Q F Y Y L P A V Y I L V F I I G F L G N S V A I W M F V F H M K P W S G I S V Y M F N L A L A D F L Y V L T L P A L I F Y Y F N K T D W I F G D A M C K L Q R F I F H V N L Y G S I L F L T C I S A H R Y S G V V Y P K S L G R L K K K N A I C I S V L V W L I V V V A I S P I L F Y S G T G V R K N K T I T C Y D T T S D E Y L R S Y F I Y S M C T T V A M F C V P L V L I L G C Y G L I V R A L I Y K P L R R K S I Y L V I I V L T V F A V S Y I P F H V M K T M N L R A R L D F Q T P A M C A F N D R V Y A T Y Q V T R G L A S L N S C V N P I L Y F L A G D T F R R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4XNW	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	MRS2500	-	-	2.7	2015-04-01	10.1038/nature14287
	7XXH	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-	chim(NtGi1-G11)/&β;1/&γ;2	2.9	2023-06-07	10.1093/procel/pwac025

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Download 4XNV.zip

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