psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F40	R:R:P293	4.33	No	No	0	5	1
2	R:R:K41	R:R:Q291	9.49	No	No	0	1	2
3	R:R:C296	R:R:C42	5.46	No	No	0	4	8
4	R:R:A43	R:R:K196	4.82	No	No	0	4	2
5	R:R:D300	R:R:K46	12.44	No	No	0	2	4
6	R:R:D300	R:R:T47	11.56	No	No	0	2	2
7	R:R:F49	R:R:Y53	5.16	No	No	0	4	5
8	R:R:A304	R:R:Q50	4.55	No	No	0	3	4
9	R:R:Q307	R:R:Q50	7.68	Yes	No	0	5	4
10	R:R:Q50	R:R:V308	5.73	No	No	0	4	5
11	R:R:F51	R:R:Y111	4.13	No	Yes	0	3	5
12	R:R:F51	R:R:T115	3.89	No	No	0	3	4
13	R:R:F51	R:R:Y303	13.41	No	No	0	3	4
14	R:R:Y52	R:R:Y53	8.94	No	No	0	3	5
15	R:R:L54	R:R:Y58	5.86	Yes	Yes	0	6	7
16	R:R:L54	R:R:Y111	3.52	Yes	Yes	0	6	5
17	R:R:L54	R:R:Q307	3.99	Yes	Yes	0	6	5
18	R:R:L104	R:R:Y58	4.69	Yes	Yes	0	7	7
19	R:R:S314	R:R:Y58	7.63	No	Yes	0	7	7
20	R:R:S314	R:R:V61	4.85	No	No	0	7	6
21	R:R:C318	R:R:V61	5.12	No	No	0	7	6
22	R:R:F62	R:R:V101	3.93	No	No	0	6	5
23	R:R:F62	R:R:L104	4.87	No	Yes	0	6	7
24	R:R:F62	R:R:P105	10.11	No	No	0	6	9
25	R:R:D97	R:R:N69	13.46	No	No	0	9	9
26	R:R:F98	R:R:N69	7.25	No	No	0	7	9
27	R:R:M75	R:R:W74	4.65	Yes	No	2	7	3
28	R:R:F78	R:R:W74	12.03	No	No	2	5	3
29	R:R:H79	R:R:W74	5.29	Yes	No	2	5	3
30	R:R:H79	R:R:M75	6.57	Yes	Yes	2	5	7
31	R:R:F325	R:R:M75	4.98	Yes	Yes	2	6	7
32	R:R:L335	R:R:M75	8.48	No	Yes	2	5	7
33	R:R:F76	R:R:M80	6.22	Yes	No	3	6	5
34	R:R:F76	R:R:W83	8.02	Yes	Yes	3	6	6
35	R:R:F76	R:R:M90	3.73	Yes	No	0	6	8
36	R:R:F76	R:R:F91	11.79	Yes	No	3	6	5
37	R:R:F78	R:R:V77	7.87	No	No	0	5	3
38	R:R:F78	R:R:H79	7.92	No	Yes	2	5	5
39	R:R:A338	R:R:H79	4.39	No	Yes	0	4	5
40	R:R:M80	R:R:W83	3.49	No	Yes	3	5	6
41	R:R:M80	R:R:R334	8.69	No	No	0	5	5
42	R:R:S87	R:R:W83	12.36	No	Yes	0	7	6
43	R:R:V88	R:R:W83	4.9	No	Yes	0	6	6
44	R:R:F91	R:R:W83	14.03	No	Yes	3	5	6
45	R:R:G85	R:R:S84	3.71	No	No	0	6	7
46	R:R:I145	R:R:I86	4.42	Yes	No	0	8	7
47	R:R:H148	R:R:I86	7.95	No	No	0	8	7
48	R:R:K165	R:R:V88	4.55	No	No	0	3	6
49	R:R:C144	R:R:Y89	5.38	No	Yes	0	6	7
50	R:R:I145	R:R:Y89	3.63	Yes	Yes	0	8	7
51	R:R:H148	R:R:Y89	6.53	No	Yes	0	8	7
52	R:R:I171	R:R:Y89	6.04	No	Yes	0	5	7
53	R:R:F331	R:R:M90	3.73	No	No	0	8	8
54	R:R:F141	R:R:N92	10.87	Yes	No	4	7	9
55	R:R:N92	R:R:S172	7.45	No	No	4	9	7
56	R:R:N92	R:R:W176	11.3	No	Yes	4	9	9
57	R:R:F141	R:R:L93	4.87	Yes	No	0	7	9
58	R:R:L142	R:R:L93	5.54	Yes	No	0	8	9
59	R:R:D97	R:R:P321	14.49	No	No	0	9	9
60	R:R:F98	R:R:L102	7.31	No	No	0	7	5
61	R:R:L99	R:R:N134	9.61	No	No	0	7	8
62	R:R:L104	R:R:Y100	3.52	Yes	Yes	0	7	7
63	R:R:F131	R:R:Y100	14.44	No	Yes	0	7	7
64	R:R:N134	R:R:Y100	4.65	No	Yes	0	8	7
65	R:R:L135	R:R:Y100	10.55	No	Yes	0	7	7
66	R:R:Q127	R:R:T103	4.25	Yes	No	1	4	6
67	R:R:I130	R:R:T103	10.64	No	No	1	4	6
68	R:R:A106	R:R:Q127	4.55	No	Yes	0	6	4
69	R:R:L107	R:R:R128	9.72	No	Yes	0	7	5
70	R:R:F131	R:R:L107	4.87	No	No	0	7	7
71	R:R:F109	R:R:I118	3.77	No	No	0	3	3
72	R:R:Y110	R:R:Y111	14.89	Yes	Yes	1	5	5
73	R:R:T115	R:R:Y110	4.99	No	Yes	0	4	5
74	R:R:W117	R:R:Y110	11.58	Yes	Yes	1	8	5
75	R:R:C202	R:R:Y110	6.72	Yes	Yes	1	9	5
76	L:L:?1	R:R:Y110	8.74	Yes	Yes	1	0	5
77	R:R:R310	R:R:Y111	6.17	Yes	Yes	1	5	5
78	L:L:?1	R:R:Y111	8.01	Yes	Yes	1	0	5
79	R:R:K114	R:R:N113	16.79	No	No	0	3	4
80	R:R:D116	R:R:K114	11.06	No	No	0	5	3
81	R:R:T115	R:R:T201	4.71	No	Yes	0	4	3
82	R:R:D116	R:R:T199	10.12	No	No	0	5	4
83	R:R:F119	R:R:W117	5.01	Yes	Yes	1	7	8
84	R:R:M123	R:R:W117	3.49	No	Yes	1	5	8
85	R:R:C124	R:R:W117	7.84	No	Yes	1	9	8
86	R:R:C202	R:R:W117	13.06	Yes	Yes	1	9	8
87	R:R:F119	R:R:I118	3.77	Yes	No	0	7	3
88	R:R:F119	R:R:M123	6.22	Yes	No	1	7	5
89	R:R:D121	R:R:K125	5.53	No	No	0	3	7
90	R:R:D121	R:R:T192	8.67	No	No	0	3	5
91	R:R:C124	R:R:T192	3.38	No	No	0	9	5
92	R:R:C124	R:R:C202	7.28	No	Yes	1	9	9
93	R:R:K125	R:R:S190	6.12	No	No	0	7	5
94	R:R:I130	R:R:L126	4.28	No	No	0	4	4
95	R:R:I130	R:R:Q127	8.23	No	Yes	1	4	4
96	R:R:C202	R:R:R128	9.75	Yes	Yes	1	9	5
97	R:R:D204	R:R:R128	13.1	Yes	Yes	1	6	5
98	L:L:?1	R:R:R128	4.53	Yes	Yes	1	0	5
99	R:R:F129	R:R:I183	5.02	No	No	0	6	7
100	R:R:F129	R:R:L187	19.49	No	No	0	6	5
101	R:R:F131	R:R:H132	3.39	No	No	0	7	5
102	R:R:H132	R:R:I186	3.98	No	No	0	5	4
103	R:R:D204	R:R:H132	3.78	Yes	No	0	6	5
104	R:R:I183	R:R:V133	7.68	No	No	0	7	5
105	R:R:I183	R:R:Y136	3.63	No	No	0	7	7
106	R:R:M225	R:R:Y136	7.18	No	No	0	5	7
107	R:R:G137	R:R:V179	3.68	No	No	0	6	7
108	R:R:I139	R:R:Y273	15.71	No	Yes	0	7	8
109	R:R:L140	R:R:V175	4.47	No	No	0	5	7
110	R:R:F141	R:R:V175	3.93	Yes	No	0	7	7
111	R:R:F141	R:R:W176	11.02	Yes	Yes	4	7	9
112	R:R:F269	R:R:L142	3.65	No	Yes	0	9	8
113	R:R:D320	R:R:L142	4.07	No	Yes	0	9	8
114	R:R:L142	R:R:Y324	4.69	Yes	Yes	0	8	9
115	R:R:P229	R:R:T143	5.25	No	No	0	9	8
116	R:R:I145	R:R:R149	7.52	Yes	No	5	8	9
117	R:R:I145	R:R:Y324	6.04	Yes	Yes	5	8	9
118	R:R:C236	R:R:S146	5.16	No	No	0	6	9
119	R:R:S146	R:R:Y237	8.9	No	Yes	0	9	9
120	R:R:H148	R:R:L163	12.86	No	No	0	8	8
121	R:R:R149	R:R:Y324	9.26	No	Yes	5	9	9
122	R:R:V154	R:R:Y150	7.57	No	Yes	7	7	7
123	R:R:Y150	R:R:Y155	6.95	Yes	Yes	7	7	6
124	R:R:C236	R:R:Y150	8.06	No	Yes	0	6	7
125	R:R:L239	R:R:Y150	8.21	No	Yes	0	4	7
126	R:R:G152	R:R:S151	3.71	No	No	0	7	5
127	R:R:L163	R:R:S151	4.5	No	No	0	8	5
128	R:R:I240	R:R:V153	4.61	No	No	0	7	8
129	R:R:V154	R:R:Y155	12.62	No	Yes	7	7	6
130	R:R:K158	R:R:Y155	9.55	No	Yes	0	5	6
131	R:R:R162	R:R:S159	3.95	No	No	0	4	5
132	R:R:I169	R:R:K166	5.82	No	No	0	4	5
133	R:R:S172	R:R:W176	6.18	No	Yes	4	7	9
134	R:R:P185	R:R:S184	5.34	No	No	0	8	4
135	R:R:P185	R:R:Y217	13.91	No	Yes	0	8	5
136	R:R:I186	R:R:Y214	3.63	No	Yes	0	4	4
137	R:R:I186	R:R:Y217	9.67	No	Yes	0	4	5
138	R:R:S213	R:R:Y189	3.82	No	No	0	1	4
139	R:R:Y189	R:R:Y214	8.94	No	Yes	0	4	4
140	R:R:Y189	R:R:Y217	5.96	No	Yes	0	4	5
141	R:R:G191	R:R:S190	3.71	No	No	0	4	5
142	R:R:I200	R:R:T192	4.56	No	No	0	4	5
143	R:R:K196	R:R:R195	17.33	No	Yes	0	2	1
144	R:R:N197	R:R:R195	7.23	No	Yes	0	4	1
145	R:R:R195	R:R:T201	9.06	Yes	Yes	1	1	3
146	R:R:R195	R:R:Y203	9.26	Yes	Yes	1	1	4
147	L:L:?1	R:R:R195	11.32	Yes	Yes	1	0	1
148	R:R:N197	R:R:T199	14.62	No	No	0	4	4
149	R:R:T201	R:R:Y203	19.97	Yes	Yes	1	3	4
150	L:L:?1	R:R:T201	3.66	Yes	Yes	1	0	3
151	L:L:?1	R:R:Y203	10.19	Yes	Yes	1	0	4
152	R:R:D204	R:R:T205	10.12	Yes	Yes	1	6	5
153	R:R:D204	R:R:R310	3.57	Yes	Yes	1	6	5
154	L:L:?1	R:R:D204	14.33	Yes	Yes	1	0	6
155	R:R:T205	R:R:T206	4.71	Yes	No	1	5	5
156	R:R:T205	R:R:Y214	11.24	Yes	Yes	1	5	4
157	L:L:?1	R:R:T205	10.07	Yes	Yes	1	0	5
158	R:R:L211	R:R:T206	4.42	Yes	No	0	4	5
159	R:R:T206	R:R:Y214	11.24	No	Yes	1	5	4
160	R:R:E209	R:R:S207	11.5	No	No	0	3	5
161	R:R:L211	R:R:R287	3.64	Yes	Yes	0	4	5
162	R:R:L211	R:R:L288	4.15	Yes	Yes	0	4	3
163	R:R:F215	R:R:R212	10.69	No	No	8	4	1
164	R:R:I216	R:R:R212	10.02	No	No	0	3	1
165	R:R:L288	R:R:R212	4.86	Yes	No	8	3	1
166	R:R:S218	R:R:Y214	3.82	No	Yes	0	5	4
167	R:R:F215	R:R:L284	8.53	No	No	0	4	4
168	R:R:F215	R:R:L288	4.87	No	Yes	8	4	3
169	R:R:T221	R:R:Y217	8.74	No	Yes	0	5	5
170	R:R:K280	R:R:S218	6.12	Yes	No	0	6	5
171	R:R:H277	R:R:T222	4.11	Yes	No	0	8	5
172	R:R:K280	R:R:T222	6.01	Yes	No	0	6	5
173	R:R:F226	R:R:L230	8.53	No	No	9	8	6
174	R:R:F226	R:R:I274	6.28	No	Yes	9	8	5
175	R:R:F226	R:R:H277	18.1	No	Yes	0	8	8
176	R:R:P229	R:R:V228	3.53	No	No	0	9	6
177	R:R:L230	R:R:L234	6.92	No	No	0	6	4
178	R:R:I274	R:R:L230	7.14	Yes	No	9	5	6
179	R:R:I233	R:R:Y237	9.67	No	Yes	0	8	9
180	R:R:F269	R:R:I233	6.28	No	No	0	9	8
181	R:R:L234	R:R:L266	4.15	No	No	0	4	7
182	R:R:I240	R:R:Y237	3.63	No	Yes	6	7	9
183	R:R:V262	R:R:Y237	5.05	No	Yes	6	7	9
184	R:R:V265	R:R:Y237	3.79	No	Yes	0	7	9
185	R:R:L266	R:R:Y237	10.55	No	Yes	0	7	9
186	R:R:L239	R:R:R242	3.64	No	No	0	4	5
187	R:R:I240	R:R:V262	6.14	No	No	6	7	7
188	R:R:R242	R:R:Y246	5.14	No	No	0	5	5
189	R:R:L244	R:R:R255	8.5	No	No	0	8	6
190	R:R:L244	R:R:S258	6.01	No	No	0	8	7
191	R:R:I259	R:R:L244	5.71	No	No	0	6	8
192	R:R:I245	R:R:Y246	6.04	No	No	0	3	5
193	R:R:P253	R:R:R255	8.65	No	No	0	4	6
194	R:R:L254	R:R:R256	8.5	No	No	0	4	5
195	R:R:R256	R:R:Y260	8.23	No	No	0	5	6
196	R:R:V265	R:R:Y324	5.05	No	Yes	0	7	9
197	R:R:N316	R:R:V268	8.87	No	No	0	9	6
198	R:R:F269	R:R:Y273	8.25	No	Yes	0	9	8
199	R:R:S272	R:R:Y273	6.36	No	Yes	0	8	8
200	R:R:N316	R:R:S272	10.43	No	No	0	9	8
201	R:R:H277	R:R:Y273	4.36	Yes	Yes	0	8	8
202	R:R:S317	R:R:Y273	3.82	No	Yes	0	9	8
203	R:R:I274	R:R:P275	5.08	Yes	No	0	5	9
204	R:R:F276	R:R:H277	10.18	No	Yes	0	7	8
205	R:R:F276	R:R:Y306	4.13	No	Yes	0	7	4
206	R:R:A313	R:R:F276	5.55	No	No	0	7	7
207	R:R:M279	R:R:T309	4.52	Yes	No	0	5	7
208	R:R:K280	R:R:L284	5.64	Yes	No	0	6	4
209	R:R:K280	R:R:Y306	8.36	Yes	Yes	0	6	4
210	R:R:N283	R:R:R287	9.64	No	Yes	0	4	5
211	R:R:N283	R:R:V302	4.43	No	No	0	4	4
212	R:R:N283	R:R:Y306	8.14	No	Yes	0	4	4
213	R:R:D289	R:R:R285	9.53	No	No	0	1	4
214	R:R:A286	R:R:F290	5.55	No	No	0	1	3
215	R:R:Q291	R:R:R287	10.51	No	Yes	0	2	5
216	L:L:?1	R:R:R287	10.56	Yes	Yes	0	0	5
217	R:R:F290	R:R:F298	5.36	No	No	0	3	1
218	R:R:F290	R:R:N299	6.04	No	No	0	3	2
219	R:R:P293	R:R:T292	3.5	No	No	0	1	2
220	R:R:F298	R:R:R301	10.69	No	No	0	1	2
221	R:R:F298	R:R:V302	7.87	No	No	0	1	4
222	R:R:Q307	R:R:Y303	19.16	Yes	No	0	5	4
223	L:L:?1	R:R:Y303	10.92	Yes	No	0	0	4
224	R:R:Q307	R:R:Y306	5.64	Yes	Yes	1	5	4
225	R:R:T309	R:R:Y306	3.75	No	Yes	0	7	4
226	R:R:R310	R:R:Y306	14.4	Yes	Yes	1	5	4
227	R:R:Q307	R:R:R310	8.18	Yes	Yes	1	5	5
228	R:R:L312	R:R:L315	4.15	No	No	0	7	5
229	R:R:D320	R:R:N316	10.77	No	No	0	9	9
230	R:R:F325	R:R:L326	3.65	Yes	No	0	6	6
231	R:R:F325	R:R:F331	4.29	Yes	No	0	6	8
232	R:R:F325	R:R:L335	4.87	Yes	No	2	6	5
233	R:R:G328	R:R:R332	7.51	No	No	0	8	8
234	R:R:D329	R:R:T330	5.78	No	No	0	5	6
235	R:R:R333	R:R:S336	7.91	No	No	0	5	5
236	R:R:K81	R:R:P82	3.35	No	No	0	6	5
237	R:R:Q127	R:R:W117	3.29	Yes	Yes	1	4	8
238	R:R:L54	R:R:P55	3.28	Yes	No	0	6	6
239	R:R:L93	R:R:P321	3.28	No	No	0	9	9
240	R:R:S84	R:R:S87	3.26	No	No	0	7	7
241	R:R:S138	R:R:S317	3.26	No	No	0	9	9
242	R:R:S151	R:R:S159	3.26	No	No	0	5	5
243	R:R:A182	R:R:M225	3.22	No	No	0	4	5
244	R:R:V241	R:R:V262	3.21	No	No	0	5	7
245	R:R:R333	R:R:R340	3.2	No	No	0	5	6
246	R:R:I86	R:R:S84	3.1	No	No	0	7	7
247	R:R:I178	R:R:V175	3.07	No	No	0	5	7
248	R:R:I263	R:R:V241	3.07	No	No	0	4	5
249	R:R:K247	R:R:S252	3.06	No	No	0	4	3
250	R:R:C42	R:R:Q291	3.05	No	No	0	8	2
251	R:R:M279	R:R:T305	3.01	Yes	No	0	5	4
252	R:R:L323	R:R:V265	2.98	No	No	0	7	7
253	R:R:N134	R:R:V133	2.96	No	No	0	8	5
254	R:R:L232	R:R:T143	2.95	No	No	0	6	8
255	R:R:I108	R:R:I59	2.94	No	No	0	7	5
256	R:R:I322	R:R:I64	2.94	No	No	0	6	5
257	R:R:I245	R:R:I259	2.94	No	No	0	3	6
258	R:R:G193	R:R:Y203	2.9	No	Yes	0	2	4
259	R:R:I63	R:R:L67	2.85	No	No	0	5	4
260	R:R:I108	R:R:L104	2.85	No	Yes	0	7	7
261	R:R:I264	R:R:L261	2.85	No	No	0	4	7
262	R:R:I264	R:R:L323	2.85	No	No	0	4	7
263	R:R:I171	R:R:N167	2.83	No	No	0	5	4
264	R:R:A96	R:R:F141	2.77	No	Yes	0	8	7
265	L:L:?1	R:R:T45	2.75	Yes	No	0	0	3
266	R:R:D208	R:R:L211	2.71	No	Yes	0	3	4
267	R:R:D289	R:R:L288	2.71	No	Yes	0	1	3
268	R:R:A168	R:R:Y89	2.67	No	Yes	0	8	7
269	R:R:F331	R:R:T330	2.59	No	No	0	8	6
270	R:R:F91	R:R:I73	2.51	No	No	0	5	7
271	R:R:F66	R:R:F98	2.14	No	No	0	5	7
272	R:R:C318	R:R:G65	1.96	No	No	0	7	8
273	R:R:G311	R:R:S314	1.86	No	No	0	4	7
274	R:R:G68	R:R:V71	1.84	No	No	0	6	5
275	R:R:G238	R:R:V241	1.84	No	No	0	3	5
276	R:R:P253	R:R:S252	1.78	No	No	0	4	3
277	R:R:G65	R:R:I64	1.76	No	No	0	8	5
278	R:R:G68	R:R:L67	1.71	No	No	0	6	4
279	R:R:G137	R:R:L140	1.71	No	No	0	6	5
280	R:R:C227	R:R:V231	1.71	No	No	0	4	3
281	R:R:G235	R:R:L234	1.71	No	No	0	3	4
282	R:R:A243	R:R:V153	1.7	No	No	0	5	8
283	R:R:A243	R:R:V154	1.7	No	No	0	5	7
284	R:R:A304	R:R:T47	1.68	No	No	0	3	2
285	R:R:A294	R:R:T292	1.68	No	No	0	3	2
286	R:R:S70	R:R:V71	1.62	No	No	0	3	5
287	R:R:A94	R:R:I73	1.62	No	No	0	9	7
288	R:R:C170	R:R:K166	1.62	No	No	0	3	5
289	R:R:C220	R:R:M219	1.62	No	No	0	3	4
290	R:R:A270	R:R:I274	1.62	No	Yes	0	5	5
291	R:R:A122	R:R:M123	1.61	No	No	0	1	5
292	R:R:A327	R:R:K257	1.61	No	No	0	6	8
293	R:R:V133	R:R:V180	1.6	No	No	0	5	4
294	R:R:V268	R:R:V319	1.6	No	No	0	6	5
295	R:R:T267	R:R:V271	1.59	No	No	0	4	6
296	R:R:A327	R:R:L261	1.58	No	No	0	6	7
297	R:R:I169	R:R:V173	1.54	No	No	0	4	4
298	R:R:I139	R:R:T143	1.52	No	No	0	7	8
299	R:R:M219	R:R:V223	1.52	No	No	0	4	5
300	R:R:I263	R:R:T267	1.52	No	No	0	4	4
301	R:R:M279	R:R:V278	1.52	Yes	No	0	5	6
302	R:R:F119	R:R:G120	1.51	Yes	No	0	7	6
303	R:R:L249	R:R:S252	1.5	No	No	0	3	3
304	R:R:L312	R:R:S272	1.5	No	No	0	7	8
305	R:R:K280	R:R:T281	1.5	Yes	No	0	6	5
306	R:R:L335	R:R:T339	1.47	No	No	0	5	4
307	R:R:I216	R:R:M219	1.46	No	No	0	3	4
308	R:R:M279	R:R:M282	1.44	Yes	No	0	5	5
309	R:R:K164	R:R:N167	1.4	No	No	0	6	4
310	R:R:A72	R:R:F325	1.39	No	Yes	0	8	6
311	R:R:P156	R:R:Y155	1.39	No	Yes	0	8	6
312	R:R:L157	R:R:L160	1.38	No	No	0	5	5
313	R:R:F188	R:R:S184	1.32	No	No	0	4	4
314	R:R:R340	R:R:T339	1.29	No	No	0	6	4
315	R:R:S207	R:R:Y203	1.27	No	Yes	0	5	4
316	R:R:V57	R:R:Y58	1.26	No	Yes	0	4	7
317	R:R:F66	R:R:L67	1.22	No	No	0	5	4
318	R:R:L326	R:R:R332	1.21	No	No	0	6	8
319	R:R:L95	R:R:W176	1.14	No	Yes	0	5	9
320	R:R:E209	R:R:Y210	1.12	No	No	0	3	4
321	R:R:R333	R:R:R337	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L54	4.1625	4	0	6
2	R:R:Y58	4.86	4	0	7
3	R:R:M75	6.17	4	2	7
4	R:R:F76	7.44	4	3	6
5	R:R:H79	6.0425	4	2	5
6	R:R:W83	8.56	5	3	6
7	R:R:Y89	4.85	5	0	7
8	R:R:Y100	8.29	4	0	7
9	R:R:L104	3.9825	4	0	7
10	R:R:Y110	9.384	5	1	5
11	R:R:Y111	7.344	5	1	5
12	R:R:W117	7.37833	6	1	8
13	R:R:F119	4.1275	4	1	7
14	R:R:Q127	5.08	4	1	4
15	R:R:R128	9.275	4	1	5
16	R:R:F141	6.692	5	4	7
17	R:R:L142	4.4875	4	0	8
18	R:R:I145	5.4025	4	5	8
19	R:R:Y150	7.6975	4	7	7
20	R:R:Y155	7.6275	4	7	6
21	R:R:W176	7.41	4	4	9
22	R:R:R195	10.84	5	1	1
23	R:R:T201	9.35	4	1	3
24	R:R:C202	9.2025	4	1	9
25	R:R:Y203	8.718	5	1	4
26	R:R:D204	8.98	5	1	6
27	R:R:T205	9.035	4	1	5
28	R:R:L211	3.73	4	0	4
29	R:R:Y214	7.774	5	1	4
30	R:R:Y217	9.57	4	0	5
31	R:R:Y237	6.93167	6	6	9
32	R:R:Y273	7.7	5	0	8
33	R:R:I274	5.03	4	9	5
34	R:R:H277	9.1875	4	0	8
35	R:R:M279	2.6225	4	0	5
36	R:R:K280	5.526	5	0	6
37	R:R:R287	8.5875	4	0	5
38	R:R:L288	4.1475	4	8	3
39	R:R:Y306	7.40333	6	1	4
40	R:R:Q307	8.93	5	1	5
41	R:R:R310	8.08	4	1	5
42	R:R:Y324	6.26	4	5	9
43	R:R:F325	3.836	5	2	6
44	L:L:?1	8.64364	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R195	20.7129	11.32	Yes	Yes	1	0	1
2	L:L:?1	R:R:R287	16.8327	10.56	Yes	Yes	0	0	5
3	R:R:Q307	R:R:Y303	11.5592	19.16	Yes	No	0	5	4
4	L:L:?1	R:R:Y303	10.4134	10.92	Yes	No	0	0	4
5	R:R:Q307	R:R:Y306	30.7227	5.64	Yes	Yes	1	5	4
6	R:R:N283	R:R:Y306	17.8092	8.14	No	Yes	0	4	4
7	R:R:N283	R:R:R287	15.5664	9.64	No	Yes	0	4	5
8	L:L:?1	R:R:Y111	11.0059	8.01	Yes	Yes	1	0	5
9	R:R:L54	R:R:Y58	19.8763	5.86	Yes	Yes	0	6	7
10	R:R:L104	R:R:Y58	13.0208	4.69	Yes	Yes	0	7	7
11	R:R:D97	R:R:P321	12.4967	14.49	No	No	0	9	9
12	R:R:L93	R:R:P321	13.7109	3.28	No	No	0	9	9
13	R:R:L142	R:R:L93	28.903	5.54	Yes	No	0	8	9
14	R:R:F269	R:R:L142	69.6517	3.65	No	Yes	0	9	8
15	R:R:F269	R:R:Y273	94.0625	8.25	No	Yes	0	9	8
16	R:R:H277	R:R:Y273	100	4.36	Yes	Yes	0	8	8
17	R:R:F276	R:R:H277	89.5833	10.18	No	Yes	0	7	8
18	R:R:F276	R:R:Y306	90.0326	4.13	No	Yes	0	7	4
19	R:R:D97	R:R:N69	11.276	13.46	No	No	0	9	9
20	R:R:F98	R:R:N69	10.0488	7.25	No	No	0	7	9
21	R:R:L142	R:R:Y324	56.4681	4.69	Yes	Yes	0	8	9
22	R:R:I145	R:R:Y324	54.6582	6.04	Yes	Yes	5	8	9
23	R:R:I145	R:R:I86	42.6009	4.42	Yes	No	0	8	7
24	R:R:I86	R:R:S84	36.9238	3.1	No	No	0	7	7
25	R:R:S84	R:R:S87	34.9902	3.26	No	No	0	7	7
26	R:R:S87	R:R:W83	34.0137	12.36	No	Yes	0	7	6
27	R:R:F76	R:R:W83	25.8431	8.02	Yes	Yes	3	6	6
28	R:R:F76	R:R:M90	25.2702	3.73	Yes	No	0	6	8
29	R:R:F331	R:R:M90	24.2253	3.73	No	No	0	8	8
30	R:R:F325	R:R:F331	21.1556	4.29	Yes	No	0	6	8
31	R:R:I145	R:R:Y89	12.7376	3.63	Yes	Yes	0	8	7
32	R:R:F141	R:R:L93	14.9186	4.87	Yes	No	0	7	9
33	R:R:F131	R:R:Y100	13.5872	14.44	No	Yes	0	7	7
34	R:R:N134	R:R:Y100	17.2493	4.65	No	Yes	0	8	7
35	L:L:?1	R:R:D204	11.6146	14.33	Yes	Yes	1	0	6
36	R:R:D204	R:R:H132	12.6107	3.78	Yes	No	0	6	5
37	R:R:F131	R:R:H132	11.569	3.39	No	No	0	7	5
38	R:R:W117	R:R:Y110	16.3672	11.58	Yes	Yes	1	8	5
39	R:R:R310	R:R:Y306	48.7533	14.4	Yes	Yes	1	5	4
40	R:R:R310	R:R:Y111	26.3607	6.17	Yes	Yes	1	5	5
41	R:R:D204	R:R:R310	23.7467	3.57	Yes	Yes	1	6	5
42	R:R:N197	R:R:T199	10.5827	14.62	No	No	0	4	4
43	R:R:N197	R:R:R195	13.2129	7.23	No	Yes	0	4	1
44	R:R:C124	R:R:C202	11.709	7.28	No	Yes	1	9	9
45	R:R:D121	R:R:T192	10.1921	8.67	No	No	0	3	5
46	R:R:C124	R:R:T192	15.2507	3.38	No	No	0	9	5
47	R:R:I183	R:R:V133	10.4264	7.68	No	No	0	7	5
48	R:R:N134	R:R:V133	13.8509	2.96	No	No	0	8	5
49	R:R:C236	R:R:S146	21.4941	5.16	No	No	0	6	9
50	R:R:S146	R:R:Y237	22.6367	8.9	No	Yes	0	9	9
51	R:R:I233	R:R:Y237	30.1107	9.67	No	Yes	0	8	9
52	R:R:F269	R:R:I233	30.8268	6.28	No	No	0	9	8
53	R:R:H148	R:R:L163	10.8203	12.86	No	No	0	8	8
54	R:R:C236	R:R:Y150	20.3516	8.06	No	Yes	0	6	7
55	R:R:L239	R:R:Y150	14.6647	8.21	No	Yes	0	4	7
56	L:L:?1	R:R:Y203	13.0339	10.19	Yes	Yes	1	0	4
57	R:R:K280	R:R:T222	15	6.01	Yes	No	0	6	5
58	R:R:V265	R:R:Y324	16.1686	5.05	No	Yes	0	7	9
59	R:R:V265	R:R:Y237	15.0781	3.79	No	Yes	0	7	9
60	R:R:L239	R:R:R242	13.4701	3.64	No	No	0	4	5
61	R:R:R242	R:R:Y246	12.2689	5.14	No	No	0	5	5
62	R:R:I245	R:R:Y246	11.0612	6.04	No	No	0	3	5
63	R:R:L54	R:R:Q307	18.0241	3.99	Yes	Yes	0	6	5
64	R:R:Y110	R:R:Y111	18.5742	14.89	Yes	Yes	1	5	5
65	R:R:H277	R:R:T222	14.7038	4.11	Yes	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F51	R:R:Y111	4.13	0	No	Yes	3	5	2	1
R:R:F51	R:R:T115	3.89	0	No	No	3	4	2	2
R:R:F51	R:R:Y303	13.41	0	No	No	3	4	2	1
R:R:L54	R:R:Y111	3.52	0	Yes	Yes	6	5	2	1
R:R:L54	R:R:Q307	3.99	0	Yes	Yes	6	5	2	2
R:R:L107	R:R:R128	9.72	0	No	Yes	7	5	2	1
R:R:Y110	R:R:Y111	14.89	1	Yes	Yes	5	5	1	1
R:R:T115	R:R:Y110	4.99	0	No	Yes	4	5	2	1
R:R:W117	R:R:Y110	11.58	1	Yes	Yes	8	5	2	1
R:R:C202	R:R:Y110	6.72	1	Yes	Yes	9	5	2	1
L:L:?1	R:R:Y110	8.74	1	Yes	Yes	0	5	0	1
R:R:R310	R:R:Y111	6.17	1	Yes	Yes	5	5	2	1
L:L:?1	R:R:Y111	8.01	1	Yes	Yes	0	5	0	1
R:R:T115	R:R:T201	4.71	0	No	Yes	4	3	2	1
R:R:C202	R:R:W117	13.06	1	Yes	Yes	9	8	2	2
R:R:C202	R:R:R128	9.75	1	Yes	Yes	9	5	2	1
R:R:D204	R:R:R128	13.1	1	Yes	Yes	6	5	1	1
L:L:?1	R:R:R128	4.53	1	Yes	Yes	0	5	0	1
R:R:D204	R:R:H132	3.78	1	Yes	No	6	5	1	2
R:R:K196	R:R:R195	17.33	0	No	Yes	2	1	2	1
R:R:N197	R:R:R195	7.23	0	No	Yes	4	1	2	1
R:R:R195	R:R:T201	9.06	1	Yes	Yes	1	3	1	1
R:R:R195	R:R:Y203	9.26	1	Yes	Yes	1	4	1	1
L:L:?1	R:R:R195	11.32	1	Yes	Yes	0	1	0	1
R:R:T201	R:R:Y203	19.97	1	Yes	Yes	3	4	1	1
L:L:?1	R:R:T201	3.66	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y203	10.19	1	Yes	Yes	0	4	0	1
R:R:D204	R:R:T205	10.12	1	Yes	Yes	6	5	1	1
R:R:D204	R:R:R310	3.57	1	Yes	Yes	6	5	1	2
L:L:?1	R:R:D204	14.33	1	Yes	Yes	0	6	0	1
R:R:T205	R:R:T206	4.71	1	Yes	No	5	5	1	2
R:R:T205	R:R:Y214	11.24	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:T205	10.07	1	Yes	Yes	0	5	0	1
R:R:L211	R:R:T206	4.42	0	Yes	No	4	5	2	2
R:R:T206	R:R:Y214	11.24	1	No	Yes	5	4	2	2
R:R:L211	R:R:R287	3.64	0	Yes	Yes	4	5	2	1
R:R:N283	R:R:R287	9.64	0	No	Yes	4	5	2	1
R:R:Q291	R:R:R287	10.51	0	No	Yes	2	5	2	1
L:L:?1	R:R:R287	10.56	1	Yes	Yes	0	5	0	1
R:R:Q307	R:R:Y303	19.16	1	Yes	No	5	4	2	1
L:L:?1	R:R:Y303	10.92	1	Yes	No	0	4	0	1
R:R:Q307	R:R:R310	8.18	1	Yes	Yes	5	5	2	2
R:R:G193	R:R:Y203	2.9	0	No	Yes	2	4	2	1
L:L:?1	R:R:T45	2.75	1	Yes	No	0	3	0	1
R:R:S207	R:R:Y203	1.27	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XXH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.38
Number of Linked Nodes	284
Number of Links	321
Number of Hubs	44
Number of Links mediated by Hubs	158
Number of Communities	9
Number of Nodes involved in Communities	51
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	57375
Length Of Smallest Path	3
Average Path Length	13.7738
Length of Longest Path	32
Minimum Path Strength	1.38
Average Path Strength	6.65599
Maximum Path Strength	14.6825
Minimum Path Correlation	0.7
Average Path Correlation	0.930857
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	48.8453
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8368
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• A1 adenosine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • adenosine receptor binding • adenyl ribonucleotide binding • nucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • adenyl nucleotide binding • ATP binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • ADP binding • G protein-coupled purinergic nucleotide receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled ATP receptor activity • protein heterodimerization activity • protein dimerization activity • scaffold protein binding • G protein-coupled ADP receptor activity • multicellular organismal process • regulation of biological process • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • biological regulation • positive regulation of biological process • mating behavior • behavior • positive regulation of penile erection • positive regulation of multicellular organismal process • reproductive behavior • regulation of multicellular organismal process
Gene Ontology	Biological Process	• multicellular organismal process • regulation of biological process • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • biological regulation • positive regulation of biological process • mating behavior • behavior • positive regulation of penile erection • positive regulation of multicellular organismal process • reproductive behavior • regulation of multicellular organismal process • penile erection • copulation • positive regulation of reproductive process • positive regulation of cell communication • regulation of localization • regulation of cellular process • regulation of hormone secretion • signaling • transport • positive regulation of secretion by cell • hormone secretion • cell communication • localization • positive regulation of hormone secretion • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • regulation of biological quality • positive regulation of cellular process • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • positive regulation of transport • regulation of cell communication • hormone transport • cellular process • positive regulation of signaling • monoatomic ion transport • protein localization • protein localization to cell periphery • cellular localization • protein localization to plasma membrane • cellular macromolecule localization • macromolecule localization • localization within membrane • protein localization to membrane • cellular response to stimulus • purinergic nucleotide receptor signaling pathway • response to stimulus • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • G protein-coupled adenosine receptor signaling pathway • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • signal transduction involved in regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • cellular response to ATP • response to organophosphorus • response to oxygen-containing compound • response to nitrogen compound • response to ATP • response to purine-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of inositol phosphate biosynthetic process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of inositol trisphosphate biosynthetic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • positive regulation of phosphorus metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of carbohydrate metabolic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulated exocytosis • modulation of chemical synaptic transmission • synaptic vesicle cycle • synaptic vesicle exocytosis • vesicle-mediated transport • vesicle-mediated transport in synapse • regulation of regulated secretory pathway • synaptic signaling • establishment of localization in cell • trans-synaptic signaling • neurotransmitter secretion • regulation of neurotransmitter transport • regulation of synaptic vesicle exocytosis • neurotransmitter transport • regulation of vesicle-mediated transport • chemical synaptic transmission • signal release from synapse • regulation of trans-synaptic signaling • exocytosis • regulation of neurotransmitter secretion • anterograde trans-synaptic signaling • regulation of exocytosis • regulation of monoatomic ion transport • positive regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • eating behavior • feeding behavior • developmental process • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • cellular response to purine-containing compound • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • response to endogenous stimulus • response to growth factor • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular developmental process • glial cell migration • nervous system development • neurogenesis • multicellular organism development • gliogenesis • cell differentiation • cell migration • cell motility • system development • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • blood circulation • regulation of anatomical structure size • monoamine transport • nitrogen compound transport • negative regulation of amine transport • regulation of catecholamine secretion • negative regulation of biological process • negative regulation of transport • organic hydroxy compound transport • negative regulation of secretion • catecholamine transport • negative regulation of cellular process • negative regulation of norepinephrine secretion • negative regulation of secretion by cell • norepinephrine transport • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • muscle system process • relaxation of muscle • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • somatodendritic compartment
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • glutamatergic synapse • cell body • membrane-bounded organelle • organelle • cilium • apical part of cell • apical plasma membrane • cell surface • presynaptic active zone membrane • presynaptic membrane • presynapse • presynaptic active zone • postsynaptic density • neuron to neuron synapse • postsynaptic specialization • asymmetric synapse • enzyme regulator activity • molecular function regulator activity • catalytic activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D2 dopamine receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • cyclase regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • heart development • multicellular organism development • multicellular organismal process • anatomical structure development • animal organ development • circulatory system development • system development • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • rhythmic process • regulation of biological process • entrainment of circadian clock • response to stimulus • circadian rhythm • response to external stimulus • regulation of circadian rhythm • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • signaling • cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway • signal transduction • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • skeletal system development • cranial skeletal system development • action potential • regulation of membrane potential • pigment cell differentiation • cellular developmental process • regulation of developmental process • developmental pigmentation • regulation of pigment cell differentiation • regulation of cell differentiation • pigmentation • cell differentiation • melanocyte differentiation • regulation of melanocyte differentiation • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to abiotic stimulus • cellular response to environmental stimulus • endothelin receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • cellular macromolecule localization • positive regulation of insulin secretion • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • positive regulation of protein localization • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • positive regulation of protein secretion • peptide transport • positive regulation of transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • ligand-gated ion channel signaling pathway • phospholipase C-activating dopamine receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • photoreceptor disc membrane • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	6AD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	6AD
Name	2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate)
Synonyms	2-methylthio-adenosine-5'-diphosphate
Identifier
Formula	C11 H17 N5 O10 P2 S
Molecular Weight	473.293
SMILES
PubChem	121990
Formal Charge	0
Total Atoms	46
Total Chiral Atoms	4
Total Bonds	48
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47900
Sequence	>7XXH_nogp_Chain_R F K C A L T K T G F Q F Y Y L P A V Y I L V F I I G F L G N S V A I W M F V F H M K P W S G I S V Y M F N L A L A D F L Y V L T L P A L I F Y Y F N K T D W I F G D A M C K L Q R F I F H V N L Y G S I L F L T C I S A H R Y S G V V Y P L K S L G R L K K K N A I C I S V L V W L I V V V A I S P I L F Y S G T G V R K N K T I T C Y D T T S D E Y L R S Y F I Y S M C T T V A M F C V P L V L I L G C Y G L I V R A L I Y K D L D N S P L R R K S I Y L V I I V L T V F A V S Y I P F H V M K T M N L R A R L D F Q T P A M C A F N D R V Y A T Y Q V T R G L A S L N S C V D P I L Y F L A G D T F R R R L S R A T R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WJX	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-	chim(Gs-CtGq)/β1/γ2	3.2	2024-10-02	To be published
	8WJX (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-		3.2	2024-10-02	To be published
	8KGG	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-	chim(NtGi2-G13)/β1/γ2	3.06	2024-07-31	To be published
	8KGG (No Gprot)	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-		3.06	2024-07-31	To be published
	7XXH	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-	chim(NtGi1-G11)/β1/γ2	2.9	2023-06-07	10.1093/procel/pwac025
	7XXH (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-		2.9	2023-06-07	10.1093/procel/pwac025
	4XNW	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	MRS2500	-	-	2.7	2015-04-01	10.1038/nature14287
	4XNV	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	-	BPTU	-	2.2	2015-04-01	10.1038/nature14287

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