psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F40	R:R:P293	4.33	No	No	0	5	1
2	R:R:K41	R:R:Q291	9.49	No	No	0	1	2
3	R:R:C296	R:R:C42	5.46	No	No	0	4	8
4	R:R:A43	R:R:K196	4.82	No	No	0	4	2
5	R:R:D300	R:R:K46	12.44	No	No	0	2	4
6	R:R:D300	R:R:T47	11.56	No	No	0	2	2
7	R:R:F49	R:R:Y53	5.16	No	No	0	4	5
8	R:R:A304	R:R:Q50	4.55	No	No	0	3	4
9	R:R:Q307	R:R:Q50	7.68	Yes	No	0	5	4
10	R:R:Q50	R:R:V308	5.73	No	No	0	4	5
11	R:R:F51	R:R:Y111	4.13	No	Yes	0	3	5
12	R:R:F51	R:R:T115	3.89	No	No	0	3	4
13	R:R:F51	R:R:Y303	13.41	No	No	0	3	4
14	R:R:Y52	R:R:Y53	8.94	No	No	0	3	5
15	R:R:L54	R:R:Y58	5.86	Yes	Yes	0	6	7
16	R:R:L54	R:R:Y111	3.52	Yes	Yes	0	6	5
17	R:R:L54	R:R:Q307	3.99	Yes	Yes	0	6	5
18	R:R:L104	R:R:Y58	4.69	Yes	Yes	0	7	7
19	R:R:S314	R:R:Y58	7.63	No	Yes	0	7	7
20	R:R:S314	R:R:V61	4.85	No	No	0	7	6
21	R:R:C318	R:R:V61	5.12	No	No	0	7	6
22	R:R:F62	R:R:V101	3.93	No	No	0	6	5
23	R:R:F62	R:R:L104	4.87	No	Yes	0	6	7
24	R:R:F62	R:R:P105	10.11	No	No	0	6	9
25	R:R:D97	R:R:N69	13.46	No	No	0	9	9
26	R:R:F98	R:R:N69	7.25	No	No	0	7	9
27	R:R:M75	R:R:W74	4.65	Yes	No	2	7	3
28	R:R:F78	R:R:W74	12.03	No	No	2	5	3
29	R:R:H79	R:R:W74	5.29	Yes	No	2	5	3
30	R:R:H79	R:R:M75	6.57	Yes	Yes	2	5	7
31	R:R:F325	R:R:M75	4.98	Yes	Yes	2	6	7
32	R:R:L335	R:R:M75	8.48	No	Yes	2	5	7
33	R:R:F76	R:R:M80	6.22	Yes	No	3	6	5
34	R:R:F76	R:R:W83	8.02	Yes	Yes	3	6	6
35	R:R:F76	R:R:M90	3.73	Yes	No	0	6	8
36	R:R:F76	R:R:F91	11.79	Yes	No	3	6	5
37	R:R:F78	R:R:V77	7.87	No	No	0	5	3
38	R:R:F78	R:R:H79	7.92	No	Yes	2	5	5
39	R:R:A338	R:R:H79	4.39	No	Yes	0	4	5
40	R:R:M80	R:R:W83	3.49	No	Yes	3	5	6
41	R:R:M80	R:R:R334	8.69	No	No	0	5	5
42	R:R:S87	R:R:W83	12.36	No	Yes	0	7	6
43	R:R:V88	R:R:W83	4.9	No	Yes	0	6	6
44	R:R:F91	R:R:W83	14.03	No	Yes	3	5	6
45	R:R:G85	R:R:S84	3.71	No	No	0	6	7
46	R:R:I145	R:R:I86	4.42	Yes	No	0	8	7
47	R:R:H148	R:R:I86	7.95	No	No	0	8	7
48	R:R:K165	R:R:V88	4.55	No	No	0	3	6
49	R:R:C144	R:R:Y89	5.38	No	Yes	0	6	7
50	R:R:I145	R:R:Y89	3.63	Yes	Yes	0	8	7
51	R:R:H148	R:R:Y89	6.53	No	Yes	0	8	7
52	R:R:I171	R:R:Y89	6.04	No	Yes	0	5	7
53	R:R:F331	R:R:M90	3.73	No	No	0	8	8
54	R:R:F141	R:R:N92	10.87	Yes	No	4	7	9
55	R:R:N92	R:R:S172	7.45	No	No	4	9	7
56	R:R:N92	R:R:W176	11.3	No	Yes	4	9	9
57	R:R:F141	R:R:L93	4.87	Yes	No	0	7	9
58	R:R:L142	R:R:L93	5.54	Yes	No	0	8	9
59	R:R:D97	R:R:P321	14.49	No	No	0	9	9
60	R:R:F98	R:R:L102	7.31	No	No	0	7	5
61	R:R:L99	R:R:N134	9.61	No	No	0	7	8
62	R:R:L104	R:R:Y100	3.52	Yes	Yes	0	7	7
63	R:R:F131	R:R:Y100	14.44	No	Yes	0	7	7
64	R:R:N134	R:R:Y100	4.65	No	Yes	0	8	7
65	R:R:L135	R:R:Y100	10.55	No	Yes	0	7	7
66	R:R:Q127	R:R:T103	4.25	Yes	No	1	4	6
67	R:R:I130	R:R:T103	10.64	No	No	1	4	6
68	R:R:A106	R:R:Q127	4.55	No	Yes	0	6	4
69	R:R:L107	R:R:R128	9.72	No	Yes	0	7	5
70	R:R:F131	R:R:L107	4.87	No	No	0	7	7
71	R:R:F109	R:R:I118	3.77	No	No	0	3	3
72	R:R:Y110	R:R:Y111	14.89	Yes	Yes	1	5	5
73	R:R:T115	R:R:Y110	4.99	No	Yes	0	4	5
74	R:R:W117	R:R:Y110	11.58	Yes	Yes	1	8	5
75	R:R:C202	R:R:Y110	6.72	Yes	Yes	1	9	5
76	L:L:?1	R:R:Y110	8.74	Yes	Yes	1	0	5
77	R:R:R310	R:R:Y111	6.17	Yes	Yes	1	5	5
78	L:L:?1	R:R:Y111	8.01	Yes	Yes	1	0	5
79	R:R:K114	R:R:N113	16.79	No	No	0	3	4
80	R:R:D116	R:R:K114	11.06	No	No	0	5	3
81	R:R:T115	R:R:T201	4.71	No	Yes	0	4	3
82	R:R:D116	R:R:T199	10.12	No	No	0	5	4
83	R:R:F119	R:R:W117	5.01	Yes	Yes	1	7	8
84	R:R:M123	R:R:W117	3.49	No	Yes	1	5	8
85	R:R:C124	R:R:W117	7.84	No	Yes	1	9	8
86	R:R:C202	R:R:W117	13.06	Yes	Yes	1	9	8
87	R:R:F119	R:R:I118	3.77	Yes	No	0	7	3
88	R:R:F119	R:R:M123	6.22	Yes	No	1	7	5
89	R:R:D121	R:R:K125	5.53	No	No	0	3	7
90	R:R:D121	R:R:T192	8.67	No	No	0	3	5
91	R:R:C124	R:R:T192	3.38	No	No	0	9	5
92	R:R:C124	R:R:C202	7.28	No	Yes	1	9	9
93	R:R:K125	R:R:S190	6.12	No	No	0	7	5
94	R:R:I130	R:R:L126	4.28	No	No	0	4	4
95	R:R:I130	R:R:Q127	8.23	No	Yes	1	4	4
96	R:R:C202	R:R:R128	9.75	Yes	Yes	1	9	5
97	R:R:D204	R:R:R128	13.1	Yes	Yes	1	6	5
98	L:L:?1	R:R:R128	4.53	Yes	Yes	1	0	5
99	R:R:F129	R:R:I183	5.02	No	No	0	6	7
100	R:R:F129	R:R:L187	19.49	No	No	0	6	5
101	R:R:F131	R:R:H132	3.39	No	No	0	7	5
102	R:R:H132	R:R:I186	3.98	No	No	0	5	4
103	R:R:D204	R:R:H132	3.78	Yes	No	0	6	5
104	R:R:I183	R:R:V133	7.68	No	No	0	7	5
105	R:R:I183	R:R:Y136	3.63	No	No	0	7	7
106	R:R:M225	R:R:Y136	7.18	No	No	0	5	7
107	R:R:G137	R:R:V179	3.68	No	No	0	6	7
108	R:R:I139	R:R:Y273	15.71	No	Yes	0	7	8
109	R:R:L140	R:R:V175	4.47	No	No	0	5	7
110	R:R:F141	R:R:V175	3.93	Yes	No	0	7	7
111	R:R:F141	R:R:W176	11.02	Yes	Yes	4	7	9
112	R:R:F269	R:R:L142	3.65	No	Yes	0	9	8
113	R:R:D320	R:R:L142	4.07	No	Yes	0	9	8
114	R:R:L142	R:R:Y324	4.69	Yes	Yes	0	8	9
115	R:R:P229	R:R:T143	5.25	No	No	0	9	8
116	R:R:I145	R:R:R149	7.52	Yes	No	5	8	9
117	R:R:I145	R:R:Y324	6.04	Yes	Yes	5	8	9
118	R:R:C236	R:R:S146	5.16	No	No	0	6	9
119	R:R:S146	R:R:Y237	8.9	No	Yes	0	9	9
120	R:R:H148	R:R:L163	12.86	No	No	0	8	8
121	R:R:R149	R:R:Y324	9.26	No	Yes	5	9	9
122	R:R:V154	R:R:Y150	7.57	No	Yes	7	7	7
123	R:R:Y150	R:R:Y155	6.95	Yes	Yes	7	7	6
124	R:R:C236	R:R:Y150	8.06	No	Yes	0	6	7
125	R:R:L239	R:R:Y150	8.21	No	Yes	0	4	7
126	R:R:G152	R:R:S151	3.71	No	No	0	7	5
127	R:R:L163	R:R:S151	4.5	No	No	0	8	5
128	R:R:I240	R:R:V153	4.61	No	No	0	7	8
129	R:R:V154	R:R:Y155	12.62	No	Yes	7	7	6
130	R:R:K158	R:R:Y155	9.55	No	Yes	0	5	6
131	R:R:R162	R:R:S159	3.95	No	No	0	4	5
132	R:R:I169	R:R:K166	5.82	No	No	0	4	5
133	R:R:S172	R:R:W176	6.18	No	Yes	4	7	9
134	R:R:P185	R:R:S184	5.34	No	No	0	8	4
135	R:R:P185	R:R:Y217	13.91	No	Yes	0	8	5
136	R:R:I186	R:R:Y214	3.63	No	Yes	0	4	4
137	R:R:I186	R:R:Y217	9.67	No	Yes	0	4	5
138	R:R:S213	R:R:Y189	3.82	No	No	0	1	4
139	R:R:Y189	R:R:Y214	8.94	No	Yes	0	4	4
140	R:R:Y189	R:R:Y217	5.96	No	Yes	0	4	5
141	R:R:G191	R:R:S190	3.71	No	No	0	4	5
142	R:R:I200	R:R:T192	4.56	No	No	0	4	5
143	R:R:K196	R:R:R195	17.33	No	Yes	0	2	1
144	R:R:N197	R:R:R195	7.23	No	Yes	0	4	1
145	R:R:R195	R:R:T201	9.06	Yes	Yes	1	1	3
146	R:R:R195	R:R:Y203	9.26	Yes	Yes	1	1	4
147	L:L:?1	R:R:R195	11.32	Yes	Yes	1	0	1
148	R:R:N197	R:R:T199	14.62	No	No	0	4	4
149	R:R:T201	R:R:Y203	19.97	Yes	Yes	1	3	4
150	L:L:?1	R:R:T201	3.66	Yes	Yes	1	0	3
151	L:L:?1	R:R:Y203	10.19	Yes	Yes	1	0	4
152	R:R:D204	R:R:T205	10.12	Yes	Yes	1	6	5
153	R:R:D204	R:R:R310	3.57	Yes	Yes	1	6	5
154	L:L:?1	R:R:D204	14.33	Yes	Yes	1	0	6
155	R:R:T205	R:R:T206	4.71	Yes	No	1	5	5
156	R:R:T205	R:R:Y214	11.24	Yes	Yes	1	5	4
157	L:L:?1	R:R:T205	10.07	Yes	Yes	1	0	5
158	R:R:L211	R:R:T206	4.42	Yes	No	0	4	5
159	R:R:T206	R:R:Y214	11.24	No	Yes	1	5	4
160	R:R:E209	R:R:S207	11.5	No	No	0	3	5
161	R:R:L211	R:R:R287	3.64	Yes	Yes	0	4	5
162	R:R:L211	R:R:L288	4.15	Yes	Yes	0	4	3
163	R:R:F215	R:R:R212	10.69	No	No	8	4	1
164	R:R:I216	R:R:R212	10.02	No	No	0	3	1
165	R:R:L288	R:R:R212	4.86	Yes	No	8	3	1
166	R:R:S218	R:R:Y214	3.82	No	Yes	0	5	4
167	R:R:F215	R:R:L284	8.53	No	No	0	4	4
168	R:R:F215	R:R:L288	4.87	No	Yes	8	4	3
169	R:R:T221	R:R:Y217	8.74	No	Yes	0	5	5
170	R:R:K280	R:R:S218	6.12	Yes	No	0	6	5
171	R:R:H277	R:R:T222	4.11	Yes	No	0	8	5
172	R:R:K280	R:R:T222	6.01	Yes	No	0	6	5
173	R:R:F226	R:R:L230	8.53	No	No	9	8	6
174	R:R:F226	R:R:I274	6.28	No	Yes	9	8	5
175	R:R:F226	R:R:H277	18.1	No	Yes	0	8	8
176	R:R:P229	R:R:V228	3.53	No	No	0	9	6
177	R:R:L230	R:R:L234	6.92	No	No	0	6	4
178	R:R:I274	R:R:L230	7.14	Yes	No	9	5	6
179	R:R:I233	R:R:Y237	9.67	No	Yes	0	8	9
180	R:R:F269	R:R:I233	6.28	No	No	0	9	8
181	R:R:L234	R:R:L266	4.15	No	No	0	4	7
182	R:R:I240	R:R:Y237	3.63	No	Yes	6	7	9
183	R:R:V262	R:R:Y237	5.05	No	Yes	6	7	9
184	R:R:V265	R:R:Y237	3.79	No	Yes	0	7	9
185	R:R:L266	R:R:Y237	10.55	No	Yes	0	7	9
186	R:R:L239	R:R:R242	3.64	No	No	0	4	5
187	R:R:I240	R:R:V262	6.14	No	No	6	7	7
188	R:R:R242	R:R:Y246	5.14	No	No	0	5	5
189	R:R:L244	R:R:R255	8.5	No	No	0	8	6
190	R:R:L244	R:R:S258	6.01	No	No	0	8	7
191	R:R:I259	R:R:L244	5.71	No	No	0	6	8
192	R:R:I245	R:R:Y246	6.04	No	No	0	3	5
193	R:R:P253	R:R:R255	8.65	No	No	0	4	6
194	R:R:L254	R:R:R256	8.5	No	No	0	4	5
195	R:R:R256	R:R:Y260	8.23	No	No	0	5	6
196	R:R:V265	R:R:Y324	5.05	No	Yes	0	7	9
197	R:R:N316	R:R:V268	8.87	No	No	0	9	6
198	R:R:F269	R:R:Y273	8.25	No	Yes	0	9	8
199	R:R:S272	R:R:Y273	6.36	No	Yes	0	8	8
200	R:R:N316	R:R:S272	10.43	No	No	0	9	8
201	R:R:H277	R:R:Y273	4.36	Yes	Yes	0	8	8
202	R:R:S317	R:R:Y273	3.82	No	Yes	0	9	8
203	R:R:I274	R:R:P275	5.08	Yes	No	0	5	9
204	R:R:F276	R:R:H277	10.18	No	Yes	0	7	8
205	R:R:F276	R:R:Y306	4.13	No	Yes	0	7	4
206	R:R:A313	R:R:F276	5.55	No	No	0	7	7
207	R:R:M279	R:R:T309	4.52	Yes	No	0	5	7
208	R:R:K280	R:R:L284	5.64	Yes	No	0	6	4
209	R:R:K280	R:R:Y306	8.36	Yes	Yes	0	6	4
210	R:R:N283	R:R:R287	9.64	No	Yes	0	4	5
211	R:R:N283	R:R:V302	4.43	No	No	0	4	4
212	R:R:N283	R:R:Y306	8.14	No	Yes	0	4	4
213	R:R:D289	R:R:R285	9.53	No	No	0	1	4
214	R:R:A286	R:R:F290	5.55	No	No	0	1	3
215	R:R:Q291	R:R:R287	10.51	No	Yes	0	2	5
216	L:L:?1	R:R:R287	10.56	Yes	Yes	0	0	5
217	R:R:F290	R:R:F298	5.36	No	No	0	3	1
218	R:R:F290	R:R:N299	6.04	No	No	0	3	2
219	R:R:P293	R:R:T292	3.5	No	No	0	1	2
220	R:R:F298	R:R:R301	10.69	No	No	0	1	2
221	R:R:F298	R:R:V302	7.87	No	No	0	1	4
222	R:R:Q307	R:R:Y303	19.16	Yes	No	0	5	4
223	L:L:?1	R:R:Y303	10.92	Yes	No	0	0	4
224	R:R:Q307	R:R:Y306	5.64	Yes	Yes	1	5	4
225	R:R:T309	R:R:Y306	3.75	No	Yes	0	7	4
226	R:R:R310	R:R:Y306	14.4	Yes	Yes	1	5	4
227	R:R:Q307	R:R:R310	8.18	Yes	Yes	1	5	5
228	R:R:L312	R:R:L315	4.15	No	No	0	7	5
229	R:R:D320	R:R:N316	10.77	No	No	0	9	9
230	R:R:F325	R:R:L326	3.65	Yes	No	0	6	6
231	R:R:F325	R:R:F331	4.29	Yes	No	0	6	8
232	R:R:F325	R:R:L335	4.87	Yes	No	2	6	5
233	R:R:G328	R:R:R332	7.51	No	No	0	8	8
234	R:R:D329	R:R:T330	5.78	No	No	0	5	6
235	R:R:R333	R:R:S336	7.91	No	No	0	5	5
236	R:R:K81	R:R:P82	3.35	No	No	0	6	5
237	R:R:Q127	R:R:W117	3.29	Yes	Yes	1	4	8
238	R:R:L54	R:R:P55	3.28	Yes	No	0	6	6
239	R:R:L93	R:R:P321	3.28	No	No	0	9	9
240	R:R:S84	R:R:S87	3.26	No	No	0	7	7
241	R:R:S138	R:R:S317	3.26	No	No	0	9	9
242	R:R:S151	R:R:S159	3.26	No	No	0	5	5
243	R:R:A182	R:R:M225	3.22	No	No	0	4	5
244	R:R:V241	R:R:V262	3.21	No	No	0	5	7
245	R:R:R333	R:R:R340	3.2	No	No	0	5	6
246	R:R:I86	R:R:S84	3.1	No	No	0	7	7
247	R:R:I178	R:R:V175	3.07	No	No	0	5	7
248	R:R:I263	R:R:V241	3.07	No	No	0	4	5
249	R:R:K247	R:R:S252	3.06	No	No	0	4	3
250	R:R:C42	R:R:Q291	3.05	No	No	0	8	2
251	R:R:M279	R:R:T305	3.01	Yes	No	0	5	4
252	R:R:L323	R:R:V265	2.98	No	No	0	7	7
253	R:R:N134	R:R:V133	2.96	No	No	0	8	5
254	R:R:L232	R:R:T143	2.95	No	No	0	6	8
255	R:R:I108	R:R:I59	2.94	No	No	0	7	5
256	R:R:I322	R:R:I64	2.94	No	No	0	6	5
257	R:R:I245	R:R:I259	2.94	No	No	0	3	6
258	R:R:G193	R:R:Y203	2.9	No	Yes	0	2	4
259	R:R:I63	R:R:L67	2.85	No	No	0	5	4
260	R:R:I108	R:R:L104	2.85	No	Yes	0	7	7
261	R:R:I264	R:R:L261	2.85	No	No	0	4	7
262	R:R:I264	R:R:L323	2.85	No	No	0	4	7
263	R:R:I171	R:R:N167	2.83	No	No	0	5	4
264	R:R:A96	R:R:F141	2.77	No	Yes	0	8	7
265	L:L:?1	R:R:T45	2.75	Yes	No	0	0	3
266	R:R:D208	R:R:L211	2.71	No	Yes	0	3	4
267	R:R:D289	R:R:L288	2.71	No	Yes	0	1	3
268	R:R:A168	R:R:Y89	2.67	No	Yes	0	8	7
269	R:R:F331	R:R:T330	2.59	No	No	0	8	6
270	R:R:F91	R:R:I73	2.51	No	No	0	5	7
271	R:R:F66	R:R:F98	2.14	No	No	0	5	7
272	R:R:C318	R:R:G65	1.96	No	No	0	7	8
273	R:R:G311	R:R:S314	1.86	No	No	0	4	7
274	R:R:G68	R:R:V71	1.84	No	No	0	6	5
275	R:R:G238	R:R:V241	1.84	No	No	0	3	5
276	R:R:P253	R:R:S252	1.78	No	No	0	4	3
277	R:R:G65	R:R:I64	1.76	No	No	0	8	5
278	R:R:G68	R:R:L67	1.71	No	No	0	6	4
279	R:R:G137	R:R:L140	1.71	No	No	0	6	5
280	R:R:C227	R:R:V231	1.71	No	No	0	4	3
281	R:R:G235	R:R:L234	1.71	No	No	0	3	4
282	R:R:A243	R:R:V153	1.7	No	No	0	5	8
283	R:R:A243	R:R:V154	1.7	No	No	0	5	7
284	R:R:A304	R:R:T47	1.68	No	No	0	3	2
285	R:R:A294	R:R:T292	1.68	No	No	0	3	2
286	R:R:S70	R:R:V71	1.62	No	No	0	3	5
287	R:R:A94	R:R:I73	1.62	No	No	0	9	7
288	R:R:C170	R:R:K166	1.62	No	No	0	3	5
289	R:R:C220	R:R:M219	1.62	No	No	0	3	4
290	R:R:A270	R:R:I274	1.62	No	Yes	0	5	5
291	R:R:A122	R:R:M123	1.61	No	No	0	1	5
292	R:R:A327	R:R:K257	1.61	No	No	0	6	8
293	R:R:V133	R:R:V180	1.6	No	No	0	5	4
294	R:R:V268	R:R:V319	1.6	No	No	0	6	5
295	R:R:T267	R:R:V271	1.59	No	No	0	4	6
296	R:R:A327	R:R:L261	1.58	No	No	0	6	7
297	R:R:I169	R:R:V173	1.54	No	No	0	4	4
298	R:R:I139	R:R:T143	1.52	No	No	0	7	8
299	R:R:M219	R:R:V223	1.52	No	No	0	4	5
300	R:R:I263	R:R:T267	1.52	No	No	0	4	4
301	R:R:M279	R:R:V278	1.52	Yes	No	0	5	6
302	R:R:F119	R:R:G120	1.51	Yes	No	0	7	6
303	R:R:L249	R:R:S252	1.5	No	No	0	3	3
304	R:R:L312	R:R:S272	1.5	No	No	0	7	8
305	R:R:K280	R:R:T281	1.5	Yes	No	0	6	5
306	R:R:L335	R:R:T339	1.47	No	No	0	5	4
307	R:R:I216	R:R:M219	1.46	No	No	0	3	4
308	R:R:M279	R:R:M282	1.44	Yes	No	0	5	5
309	R:R:K164	R:R:N167	1.4	No	No	0	6	4
310	R:R:A72	R:R:F325	1.39	No	Yes	0	8	6
311	R:R:P156	R:R:Y155	1.39	No	Yes	0	8	6
312	R:R:L157	R:R:L160	1.38	No	No	0	5	5
313	R:R:F188	R:R:S184	1.32	No	No	0	4	4
314	R:R:R340	R:R:T339	1.29	No	No	0	6	4
315	R:R:S207	R:R:Y203	1.27	No	Yes	0	5	4
316	R:R:V57	R:R:Y58	1.26	No	Yes	0	4	7
317	R:R:F66	R:R:L67	1.22	No	No	0	5	4
318	R:R:L326	R:R:R332	1.21	No	No	0	6	8
319	R:R:L95	R:R:W176	1.14	No	Yes	0	5	9
320	R:R:E209	R:R:Y210	1.12	No	No	0	3	4
321	R:R:R333	R:R:R337	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L54	4.1625	4	0	6
2	R:R:Y58	4.86	4	0	7
3	R:R:M75	6.17	4	2	7
4	R:R:F76	7.44	4	3	6
5	R:R:H79	6.0425	4	2	5
6	R:R:W83	8.56	5	3	6
7	R:R:Y89	4.85	5	0	7
8	R:R:Y100	8.29	4	0	7
9	R:R:L104	3.9825	4	0	7
10	R:R:Y110	9.384	5	1	5
11	R:R:Y111	7.344	5	1	5
12	R:R:W117	7.37833	6	1	8
13	R:R:F119	4.1275	4	1	7
14	R:R:Q127	5.08	4	1	4
15	R:R:R128	9.275	4	1	5
16	R:R:F141	6.692	5	4	7
17	R:R:L142	4.4875	4	0	8
18	R:R:I145	5.4025	4	5	8
19	R:R:Y150	7.6975	4	7	7
20	R:R:Y155	7.6275	4	7	6
21	R:R:W176	7.41	4	4	9
22	R:R:R195	10.84	5	1	1
23	R:R:T201	9.35	4	1	3
24	R:R:C202	9.2025	4	1	9
25	R:R:Y203	8.718	5	1	4
26	R:R:D204	8.98	5	1	6
27	R:R:T205	9.035	4	1	5
28	R:R:L211	3.73	4	0	4
29	R:R:Y214	7.774	5	1	4
30	R:R:Y217	9.57	4	0	5
31	R:R:Y237	6.93167	6	6	9
32	R:R:Y273	7.7	5	0	8
33	R:R:I274	5.03	4	9	5
34	R:R:H277	9.1875	4	0	8
35	R:R:M279	2.6225	4	0	5
36	R:R:K280	5.526	5	0	6
37	R:R:R287	8.5875	4	0	5
38	R:R:L288	4.1475	4	8	3
39	R:R:Y306	7.40333	6	1	4
40	R:R:Q307	8.93	5	1	5
41	R:R:R310	8.08	4	1	5
42	R:R:Y324	6.26	4	5	9
43	R:R:F325	3.836	5	2	6
44	L:L:?1	8.64364	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R195	20.7129	11.32	Yes	Yes	1	0	1
2	L:L:?1	R:R:R287	16.8327	10.56	Yes	Yes	0	0	5
3	R:R:Q307	R:R:Y303	11.5592	19.16	Yes	No	0	5	4
4	L:L:?1	R:R:Y303	10.4134	10.92	Yes	No	0	0	4
5	R:R:Q307	R:R:Y306	30.7227	5.64	Yes	Yes	1	5	4
6	R:R:N283	R:R:Y306	17.8092	8.14	No	Yes	0	4	4
7	R:R:N283	R:R:R287	15.5664	9.64	No	Yes	0	4	5
8	L:L:?1	R:R:Y111	11.0059	8.01	Yes	Yes	1	0	5
9	R:R:L54	R:R:Y58	19.8763	5.86	Yes	Yes	0	6	7
10	R:R:L104	R:R:Y58	13.0208	4.69	Yes	Yes	0	7	7
11	R:R:D97	R:R:P321	12.4967	14.49	No	No	0	9	9
12	R:R:L93	R:R:P321	13.7109	3.28	No	No	0	9	9
13	R:R:L142	R:R:L93	28.903	5.54	Yes	No	0	8	9
14	R:R:F269	R:R:L142	69.6517	3.65	No	Yes	0	9	8
15	R:R:F269	R:R:Y273	94.0625	8.25	No	Yes	0	9	8
16	R:R:H277	R:R:Y273	100	4.36	Yes	Yes	0	8	8
17	R:R:F276	R:R:H277	89.5833	10.18	No	Yes	0	7	8
18	R:R:F276	R:R:Y306	90.0326	4.13	No	Yes	0	7	4
19	R:R:D97	R:R:N69	11.276	13.46	No	No	0	9	9
20	R:R:F98	R:R:N69	10.0488	7.25	No	No	0	7	9
21	R:R:L142	R:R:Y324	56.4681	4.69	Yes	Yes	0	8	9
22	R:R:I145	R:R:Y324	54.6582	6.04	Yes	Yes	5	8	9
23	R:R:I145	R:R:I86	42.6009	4.42	Yes	No	0	8	7
24	R:R:I86	R:R:S84	36.9238	3.1	No	No	0	7	7
25	R:R:S84	R:R:S87	34.9902	3.26	No	No	0	7	7
26	R:R:S87	R:R:W83	34.0137	12.36	No	Yes	0	7	6
27	R:R:F76	R:R:W83	25.8431	8.02	Yes	Yes	3	6	6
28	R:R:F76	R:R:M90	25.2702	3.73	Yes	No	0	6	8
29	R:R:F331	R:R:M90	24.2253	3.73	No	No	0	8	8
30	R:R:F325	R:R:F331	21.1556	4.29	Yes	No	0	6	8
31	R:R:I145	R:R:Y89	12.7376	3.63	Yes	Yes	0	8	7
32	R:R:F141	R:R:L93	14.9186	4.87	Yes	No	0	7	9
33	R:R:F131	R:R:Y100	13.5872	14.44	No	Yes	0	7	7
34	R:R:N134	R:R:Y100	17.2493	4.65	No	Yes	0	8	7
35	L:L:?1	R:R:D204	11.6146	14.33	Yes	Yes	1	0	6
36	R:R:D204	R:R:H132	12.6107	3.78	Yes	No	0	6	5
37	R:R:F131	R:R:H132	11.569	3.39	No	No	0	7	5
38	R:R:W117	R:R:Y110	16.3672	11.58	Yes	Yes	1	8	5
39	R:R:R310	R:R:Y306	48.7533	14.4	Yes	Yes	1	5	4
40	R:R:R310	R:R:Y111	26.3607	6.17	Yes	Yes	1	5	5
41	R:R:D204	R:R:R310	23.7467	3.57	Yes	Yes	1	6	5
42	R:R:N197	R:R:T199	10.5827	14.62	No	No	0	4	4
43	R:R:N197	R:R:R195	13.2129	7.23	No	Yes	0	4	1
44	R:R:C124	R:R:C202	11.709	7.28	No	Yes	1	9	9
45	R:R:D121	R:R:T192	10.1921	8.67	No	No	0	3	5
46	R:R:C124	R:R:T192	15.2507	3.38	No	No	0	9	5
47	R:R:I183	R:R:V133	10.4264	7.68	No	No	0	7	5
48	R:R:N134	R:R:V133	13.8509	2.96	No	No	0	8	5
49	R:R:C236	R:R:S146	21.4941	5.16	No	No	0	6	9
50	R:R:S146	R:R:Y237	22.6367	8.9	No	Yes	0	9	9
51	R:R:I233	R:R:Y237	30.1107	9.67	No	Yes	0	8	9
52	R:R:F269	R:R:I233	30.8268	6.28	No	No	0	9	8
53	R:R:H148	R:R:L163	10.8203	12.86	No	No	0	8	8
54	R:R:C236	R:R:Y150	20.3516	8.06	No	Yes	0	6	7
55	R:R:L239	R:R:Y150	14.6647	8.21	No	Yes	0	4	7
56	L:L:?1	R:R:Y203	13.0339	10.19	Yes	Yes	1	0	4
57	R:R:K280	R:R:T222	15	6.01	Yes	No	0	6	5
58	R:R:V265	R:R:Y324	16.1686	5.05	No	Yes	0	7	9
59	R:R:V265	R:R:Y237	15.0781	3.79	No	Yes	0	7	9
60	R:R:L239	R:R:R242	13.4701	3.64	No	No	0	4	5
61	R:R:R242	R:R:Y246	12.2689	5.14	No	No	0	5	5
62	R:R:I245	R:R:Y246	11.0612	6.04	No	No	0	3	5
63	R:R:L54	R:R:Q307	18.0241	3.99	Yes	Yes	0	6	5
64	R:R:Y110	R:R:Y111	18.5742	14.89	Yes	Yes	1	5	5
65	R:R:H277	R:R:T222	14.7038	4.11	Yes	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F51	R:R:Y111	4.13	0	No	Yes	3	5	2	1
R:R:F51	R:R:T115	3.89	0	No	No	3	4	2	2
R:R:F51	R:R:Y303	13.41	0	No	No	3	4	2	1
R:R:L54	R:R:Y111	3.52	0	Yes	Yes	6	5	2	1
R:R:L54	R:R:Q307	3.99	0	Yes	Yes	6	5	2	2
R:R:L107	R:R:R128	9.72	0	No	Yes	7	5	2	1
R:R:Y110	R:R:Y111	14.89	1	Yes	Yes	5	5	1	1
R:R:T115	R:R:Y110	4.99	0	No	Yes	4	5	2	1
R:R:W117	R:R:Y110	11.58	1	Yes	Yes	8	5	2	1
R:R:C202	R:R:Y110	6.72	1	Yes	Yes	9	5	2	1
L:L:?1	R:R:Y110	8.74	1	Yes	Yes	0	5	0	1
R:R:R310	R:R:Y111	6.17	1	Yes	Yes	5	5	2	1
L:L:?1	R:R:Y111	8.01	1	Yes	Yes	0	5	0	1
R:R:T115	R:R:T201	4.71	0	No	Yes	4	3	2	1
R:R:C202	R:R:W117	13.06	1	Yes	Yes	9	8	2	2
R:R:C202	R:R:R128	9.75	1	Yes	Yes	9	5	2	1
R:R:D204	R:R:R128	13.1	1	Yes	Yes	6	5	1	1
L:L:?1	R:R:R128	4.53	1	Yes	Yes	0	5	0	1
R:R:D204	R:R:H132	3.78	1	Yes	No	6	5	1	2
R:R:K196	R:R:R195	17.33	0	No	Yes	2	1	2	1
R:R:N197	R:R:R195	7.23	0	No	Yes	4	1	2	1
R:R:R195	R:R:T201	9.06	1	Yes	Yes	1	3	1	1
R:R:R195	R:R:Y203	9.26	1	Yes	Yes	1	4	1	1
L:L:?1	R:R:R195	11.32	1	Yes	Yes	0	1	0	1
R:R:T201	R:R:Y203	19.97	1	Yes	Yes	3	4	1	1
L:L:?1	R:R:T201	3.66	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y203	10.19	1	Yes	Yes	0	4	0	1
R:R:D204	R:R:T205	10.12	1	Yes	Yes	6	5	1	1
R:R:D204	R:R:R310	3.57	1	Yes	Yes	6	5	1	2
L:L:?1	R:R:D204	14.33	1	Yes	Yes	0	6	0	1
R:R:T205	R:R:T206	4.71	1	Yes	No	5	5	1	2
R:R:T205	R:R:Y214	11.24	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:T205	10.07	1	Yes	Yes	0	5	0	1
R:R:L211	R:R:T206	4.42	0	Yes	No	4	5	2	2
R:R:T206	R:R:Y214	11.24	1	No	Yes	5	4	2	2
R:R:L211	R:R:R287	3.64	0	Yes	Yes	4	5	2	1
R:R:N283	R:R:R287	9.64	0	No	Yes	4	5	2	1
R:R:Q291	R:R:R287	10.51	0	No	Yes	2	5	2	1
L:L:?1	R:R:R287	10.56	1	Yes	Yes	0	5	0	1
R:R:Q307	R:R:Y303	19.16	1	Yes	No	5	4	2	1
L:L:?1	R:R:Y303	10.92	1	Yes	No	0	4	0	1
R:R:Q307	R:R:R310	8.18	1	Yes	Yes	5	5	2	2
R:R:G193	R:R:Y203	2.9	0	No	Yes	2	4	2	1
L:L:?1	R:R:T45	2.75	1	Yes	No	0	3	0	1
R:R:S207	R:R:Y203	1.27	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XXH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.38
Number of Linked Nodes	284
Number of Links	321
Number of Hubs	44
Number of Links mediated by Hubs	158
Number of Communities	9
Number of Nodes involved in Communities	51
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	57375
Length Of Smallest Path	3
Average Path Length	13.7738
Length of Longest Path	32
Minimum Path Strength	1.38
Average Path Strength	6.65599
Maximum Path Strength	14.6825
Minimum Path Correlation	0.7
Average Path Correlation	0.930832
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	48.845
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8368
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	6AD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	6AD
Name	2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate)
Synonyms	2-methylthio-adenosine-5'-diphosphate
Identifier
Formula	C11 H17 N5 O10 P2 S
Molecular Weight	473.293
SMILES
PubChem	121990
Formal Charge	0
Total Atoms	46
Total Chiral Atoms	4
Total Bonds	48
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47900
Sequence	>7XXH_nogp_Chain_R F K C A L T K T G F Q F Y Y L P A V Y I L V F I I G F L G N S V A I W M F V F H M K P W S G I S V Y M F N L A L A D F L Y V L T L P A L I F Y Y F N K T D W I F G D A M C K L Q R F I F H V N L Y G S I L F L T C I S A H R Y S G V V Y P L K S L G R L K K K N A I C I S V L V W L I V V V A I S P I L F Y S G T G V R K N K T I T C Y D T T S D E Y L R S Y F I Y S M C T T V A M F C V P L V L I L G C Y G L I V R A L I Y K D L D N S P L R R K S I Y L V I I V L T V F A V S Y I P F H V M K T M N L R A R L D F Q T P A M C A F N D R V Y A T Y Q V T R G L A S L N S C V D P I L Y F L A G D T F R R R L S R A T R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4XNV	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	-	BPTU	-	2.2	2015-04-01	doi.org/10.1038/nature14287
	4XNW	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	MRS2500	-	-	2.7	2015-04-01	doi.org/10.1038/nature14287
	7XXH	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-	chim(NtGi1-G11)/β1/γ2	2.9	2023-06-07	doi.org/10.1093/procel/pwac025
	7XXH (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-		2.9	2023-06-07	doi.org/10.1093/procel/pwac025
	8KGG	A	Nucleotide	P2Y	P2Y10	Homo sapiens	Lysophosphatidylserine (WJS)	-	chim(NtGi2-G13)/β1/γ2	3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	8KGG (No Gprot)	A	Nucleotide	P2Y	P2Y10	Homo sapiens	Lysophosphatidylserine (WJS)	-		3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	8WJX	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-	chim(Gs-CtGq)/β1/γ2	3.2	2024-10-02	To be published
	8WJX (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-		3.2	2024-10-02	To be published
	9JCL	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-	chim(Gs-CtGq)/β1/γ2	2.76	2025-09-10	To be published
	9JCL (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-		2.76	2025-09-10	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7XXH_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.