psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L44	13.71	Yes	No	2	0	2
2	L:L:?1	R:R:Q50	8.53	Yes	Yes	2	0	4
3	L:L:?1	R:R:Y110	6.83	Yes	Yes	2	0	5
4	L:L:?1	R:R:Y111	4.78	Yes	Yes	2	0	5
5	L:L:?1	R:R:N283	8.8	Yes	No	2	0	4
6	L:L:?1	R:R:R287	10.62	Yes	Yes	2	0	5
7	L:L:?1	R:R:N299	4.8	Yes	No	0	0	2
8	L:L:?1	R:R:Y303	12.29	Yes	Yes	2	0	4
9	L:L:?1	R:R:R310	8.49	Yes	Yes	2	0	5
10	R:R:F40	R:R:K41	8.69	No	No	0	5	1
11	R:R:C296	R:R:C42	5.46	No	No	0	4	8
12	R:R:C42	R:R:N299	7.87	No	No	0	8	2
13	R:R:L44	R:R:Y303	11.72	No	Yes	2	2	4
14	R:R:F49	R:R:K46	13.65	No	No	0	4	4
15	R:R:F51	R:R:T47	16.86	Yes	No	0	3	2
16	R:R:A304	R:R:F49	5.55	No	No	0	3	4
17	R:R:Q50	R:R:Y111	5.64	Yes	Yes	2	4	5
18	R:R:Q50	R:R:T115	5.67	Yes	No	0	4	4
19	R:R:Q50	R:R:Y303	13.53	Yes	Yes	2	4	4
20	R:R:Q307	R:R:Q50	14.08	Yes	Yes	2	5	4
21	R:R:Q50	R:R:R310	4.67	Yes	Yes	2	4	5
22	R:R:F51	R:R:Y52	6.19	Yes	No	0	3	3
23	R:R:F51	R:R:K114	11.17	Yes	No	0	3	3
24	R:R:F51	R:R:T115	7.78	Yes	No	0	3	4
25	R:R:L54	R:R:Y53	5.86	Yes	No	0	6	5
26	R:R:V57	R:R:Y53	8.83	No	No	0	4	5
27	R:R:V308	R:R:Y53	8.83	No	No	0	5	5
28	R:R:L54	R:R:Y58	4.69	Yes	Yes	2	6	7
29	R:R:L54	R:R:Y111	5.86	Yes	Yes	2	6	5
30	R:R:L54	R:R:Q307	7.99	Yes	Yes	2	6	5
31	R:R:L54	R:R:R310	4.86	Yes	Yes	2	6	5
32	R:R:F112	R:R:P55	17.34	No	No	0	4	6
33	R:R:L104	R:R:Y58	7.03	No	Yes	0	7	7
34	R:R:I108	R:R:Y58	4.84	No	Yes	0	7	7
35	R:R:Y111	R:R:Y58	4.96	Yes	Yes	2	5	7
36	R:R:S314	R:R:Y58	6.36	No	Yes	0	7	7
37	R:R:I108	R:R:I59	5.89	No	No	0	7	5
38	R:R:S314	R:R:V61	6.46	No	No	0	7	6
39	R:R:C318	R:R:V61	5.12	No	No	0	7	6
40	R:R:F62	R:R:F66	6.43	No	No	4	6	5
41	R:R:F62	R:R:P105	8.67	No	No	0	6	9
42	R:R:C318	R:R:I64	6.55	No	No	0	7	5
43	R:R:F66	R:R:F98	7.5	No	No	0	5	7
44	R:R:D97	R:R:N69	6.73	Yes	No	0	9	9
45	R:R:N69	R:R:P321	9.77	No	No	0	9	9
46	R:R:F91	R:R:I73	5.02	No	No	0	5	7
47	R:R:M75	R:R:W74	6.98	Yes	No	5	7	3
48	R:R:H79	R:R:W74	20.1	No	No	5	5	3
49	R:R:H79	R:R:M75	9.19	No	Yes	5	5	7
50	R:R:F331	R:R:M75	6.22	No	Yes	0	8	7
51	R:R:L335	R:R:M75	5.65	No	Yes	0	5	7
52	R:R:F76	R:R:M80	8.71	Yes	Yes	1	6	5
53	R:R:F76	R:R:W83	5.01	Yes	Yes	1	6	6
54	R:R:F76	R:R:M90	4.98	Yes	Yes	1	6	8
55	R:R:F76	R:R:F91	7.5	Yes	No	1	6	5
56	R:R:F325	R:R:F76	5.36	Yes	Yes	1	6	6
57	R:R:F78	R:R:V77	11.8	No	No	0	5	3
58	R:R:M80	R:R:W83	4.65	Yes	Yes	1	5	6
59	R:R:S87	R:R:W83	16.06	No	Yes	0	7	6
60	R:R:F91	R:R:W83	11.02	No	Yes	1	5	6
61	R:R:K165	R:R:W83	8.12	No	Yes	0	3	6
62	R:R:I86	R:R:M90	4.37	No	Yes	1	7	8
63	R:R:I145	R:R:I86	5.89	Yes	No	1	8	7
64	R:R:H148	R:R:I86	10.61	Yes	No	0	8	7
65	R:R:A168	R:R:V88	5.09	No	No	0	8	6
66	R:R:I169	R:R:V88	7.68	No	No	0	4	6
67	R:R:C144	R:R:Y89	10.75	No	Yes	0	6	7
68	R:R:H148	R:R:Y89	7.62	Yes	Yes	0	8	7
69	R:R:A168	R:R:Y89	5.34	No	Yes	0	8	7
70	R:R:I171	R:R:Y89	9.67	No	Yes	0	5	7
71	R:R:I145	R:R:M90	4.37	Yes	Yes	1	8	8
72	R:R:F325	R:R:M90	7.46	Yes	Yes	1	6	8
73	R:R:F141	R:R:N92	12.08	Yes	No	6	7	9
74	R:R:N92	R:R:S172	8.94	No	No	6	9	7
75	R:R:D97	R:R:L93	5.43	Yes	No	0	9	9
76	R:R:L142	R:R:L93	6.92	Yes	No	0	8	9
77	R:R:D97	R:R:S138	4.42	Yes	No	0	9	9
78	R:R:D97	R:R:S317	4.42	Yes	No	0	9	9
79	R:R:F98	R:R:L102	13.4	No	No	0	7	5
80	R:R:L99	R:R:N134	10.98	No	No	0	7	8
81	R:R:L104	R:R:Y100	9.38	No	Yes	0	7	7
82	R:R:F131	R:R:Y100	18.57	Yes	Yes	0	7	7
83	R:R:L135	R:R:Y100	8.21	No	Yes	0	7	7
84	R:R:S317	R:R:Y100	5.09	No	Yes	0	9	7
85	R:R:Q127	R:R:T103	11.34	No	No	0	4	6
86	R:R:I130	R:R:T103	6.08	No	No	0	4	6
87	R:R:F131	R:R:T103	5.19	Yes	No	0	7	6
88	R:R:A106	R:R:Q127	4.55	No	No	0	6	4
89	R:R:L107	R:R:Y111	4.69	Yes	Yes	0	7	5
90	R:R:L107	R:R:Q127	9.32	Yes	No	0	7	4
91	R:R:L107	R:R:R128	10.93	Yes	Yes	0	7	5
92	R:R:F131	R:R:L107	4.87	Yes	Yes	0	7	7
93	R:R:F109	R:R:I118	10.05	No	No	0	3	3
94	R:R:Y110	R:R:Y111	12.91	Yes	Yes	2	5	5
95	R:R:T115	R:R:Y110	7.49	No	Yes	0	4	5
96	R:R:W117	R:R:Y110	5.79	Yes	Yes	2	8	5
97	R:R:R128	R:R:Y110	5.14	Yes	Yes	0	5	5
98	R:R:R310	R:R:Y111	8.23	Yes	Yes	2	5	5
99	R:R:D116	R:R:N113	6.73	No	No	0	5	4
100	R:R:I118	R:R:W117	8.22	No	Yes	0	3	8
101	R:R:C124	R:R:W117	6.53	No	Yes	2	9	8
102	R:R:C202	R:R:W117	7.84	No	Yes	2	9	8
103	R:R:F119	R:R:G120	4.52	No	No	0	7	6
104	R:R:C124	R:R:C202	7.28	No	No	2	9	9
105	R:R:I130	R:R:L126	5.71	No	No	0	4	4
106	R:R:R128	R:R:S190	5.27	Yes	No	0	5	5
107	R:R:C202	R:R:R128	8.36	No	Yes	0	9	5
108	R:R:D204	R:R:R128	19.06	No	Yes	0	6	5
109	R:R:F129	R:R:V133	9.18	No	No	0	6	5
110	R:R:F129	R:R:L187	13.4	No	No	0	6	5
111	R:R:F131	R:R:H132	4.53	Yes	Yes	0	7	5
112	R:R:H132	R:R:Y136	6.53	Yes	Yes	0	5	7
113	R:R:H132	R:R:I186	6.63	Yes	No	0	5	4
114	R:R:D204	R:R:H132	8.82	No	Yes	0	6	5
115	R:R:N134	R:R:V133	4.43	No	No	0	8	5
116	R:R:I183	R:R:V133	4.61	No	No	0	7	5
117	R:R:L135	R:R:Y136	7.03	No	Yes	0	7	7
118	R:R:T221	R:R:Y136	6.24	No	Yes	0	5	7
119	R:R:M225	R:R:Y136	7.18	Yes	Yes	0	5	7
120	R:R:H277	R:R:Y136	8.71	Yes	Yes	0	8	7
121	R:R:K280	R:R:Y136	4.78	No	Yes	0	6	7
122	R:R:I139	R:R:Y273	16.92	No	No	0	7	8
123	R:R:L140	R:R:V175	7.45	No	No	0	5	7
124	R:R:F141	R:R:S172	5.28	Yes	No	6	7	7
125	R:R:F141	R:R:V175	10.49	Yes	No	0	7	7
126	R:R:F141	R:R:W176	11.02	Yes	No	0	7	9
127	R:R:F269	R:R:L142	4.87	Yes	Yes	0	9	8
128	R:R:D320	R:R:L142	12.21	No	Yes	1	9	8
129	R:R:L142	R:R:Y324	7.03	Yes	Yes	1	8	9
130	R:R:P229	R:R:T143	6.99	No	No	0	9	8
131	R:R:L232	R:R:T143	4.42	No	No	0	6	8
132	R:R:I145	R:R:R149	7.52	Yes	No	1	8	9
133	R:R:I145	R:R:Y324	6.04	Yes	Yes	1	8	9
134	R:R:I233	R:R:S146	9.29	No	No	1	8	9
135	R:R:S146	R:R:Y237	5.09	No	Yes	1	9	9
136	R:R:H148	R:R:L163	7.71	Yes	No	0	8	8
137	R:R:R149	R:R:Y237	9.26	No	Yes	1	9	9
138	R:R:R149	R:R:Y324	9.26	No	Yes	1	9	9
139	R:R:V154	R:R:Y150	11.36	No	Yes	7	7	7
140	R:R:Y150	R:R:Y155	5.96	Yes	Yes	7	7	6
141	R:R:C236	R:R:Y150	5.38	No	Yes	0	6	7
142	R:R:L239	R:R:Y150	10.55	No	Yes	0	4	7
143	R:R:S151	R:R:S159	4.89	No	No	0	5	5
144	R:R:V154	R:R:Y155	10.09	No	Yes	7	7	6
145	R:R:K158	R:R:Y155	5.97	No	Yes	0	5	6
146	R:R:K164	R:R:N167	6.99	No	No	0	6	4
147	R:R:I178	R:R:L174	5.71	No	No	0	5	3
148	R:R:M225	R:R:V179	4.56	Yes	No	0	5	7
149	R:R:A182	R:R:M225	4.83	No	Yes	0	4	5
150	R:R:P185	R:R:Y217	18.08	No	Yes	0	8	5
151	R:R:I186	R:R:S190	7.74	No	No	0	4	5
152	R:R:I186	R:R:Y217	7.25	No	Yes	0	4	5
153	R:R:F188	R:R:Y189	6.19	No	Yes	0	4	4
154	R:R:T206	R:R:Y189	6.24	No	Yes	3	5	4
155	R:R:Y189	R:R:Y210	4.96	Yes	No	3	4	4
156	R:R:S213	R:R:Y189	7.63	No	Yes	0	1	4
157	R:R:Y189	R:R:Y214	14.89	Yes	Yes	3	4	4
158	R:R:Y189	R:R:Y217	5.96	Yes	Yes	3	4	5
159	R:R:R195	R:R:T199	5.17	No	No	0	1	4
160	R:R:R195	R:R:T201	6.47	No	No	0	1	3
161	R:R:K196	R:R:N197	6.99	No	No	0	2	4
162	R:R:T201	R:R:Y203	9.99	No	No	0	3	4
163	R:R:S207	R:R:Y203	5.09	No	No	0	5	4
164	R:R:T205	R:R:Y214	11.24	No	Yes	3	5	4
165	R:R:L284	R:R:T205	5.9	No	No	3	4	5
166	R:R:T206	R:R:Y210	4.99	No	No	3	5	4
167	R:R:T206	R:R:Y214	8.74	No	Yes	3	5	4
168	R:R:E209	R:R:S207	11.5	No	No	0	3	5
169	R:R:D208	R:R:R287	4.76	No	Yes	0	3	5
170	R:R:E209	R:R:Y210	21.32	No	No	0	3	4
171	R:R:L211	R:R:R287	7.29	No	Yes	0	4	5
172	R:R:L211	R:R:L288	6.92	No	No	0	4	3
173	R:R:L288	R:R:R212	8.5	No	No	0	3	1
174	R:R:Y214	R:R:Y217	7.94	Yes	Yes	3	4	5
175	R:R:S218	R:R:Y214	5.09	No	Yes	0	5	4
176	R:R:L284	R:R:Y214	4.69	No	Yes	3	4	4
177	R:R:F215	R:R:L288	4.87	Yes	No	0	4	3
178	R:R:T221	R:R:Y217	7.49	No	Yes	0	5	5
179	R:R:K280	R:R:S218	6.12	No	No	0	6	5
180	R:R:M219	R:R:T281	4.52	No	No	0	4	5
181	R:R:F226	R:R:L230	8.53	No	Yes	8	8	6
182	R:R:F226	R:R:I274	5.02	No	No	8	8	5
183	R:R:F226	R:R:H277	32.81	No	Yes	0	8	8
184	R:R:L230	R:R:L234	5.54	Yes	No	0	6	4
185	R:R:F269	R:R:L230	4.87	Yes	Yes	0	9	6
186	R:R:I274	R:R:L230	8.56	No	Yes	8	5	6
187	R:R:I233	R:R:Y237	4.84	No	Yes	1	8	9
188	R:R:F269	R:R:I233	6.28	Yes	No	0	9	8
189	R:R:I240	R:R:Y237	4.84	No	Yes	0	7	9
190	R:R:V262	R:R:Y237	8.83	No	Yes	0	7	9
191	R:R:V265	R:R:Y237	5.05	No	Yes	1	7	9
192	R:R:L266	R:R:Y237	8.21	No	Yes	0	7	9
193	R:R:Y237	R:R:Y324	4.96	Yes	Yes	1	9	9
194	R:R:R242	R:R:Y246	5.14	No	No	0	5	5
195	R:R:L244	R:R:R255	19.44	No	No	0	8	6
196	R:R:I245	R:R:I259	5.89	No	Yes	0	3	6
197	R:R:L249	R:R:R255	26.73	No	No	0	3	6
198	R:R:D250	R:R:N251	17.5	No	No	0	3	4
199	R:R:L254	R:R:P253	6.57	No	No	0	4	4
200	R:R:R256	R:R:Y260	5.14	No	No	0	5	6
201	R:R:A327	R:R:L261	4.73	No	No	0	6	7
202	R:R:I264	R:R:L323	5.71	No	Yes	0	4	7
203	R:R:L323	R:R:V265	5.96	Yes	No	1	7	7
204	R:R:V265	R:R:Y324	10.09	No	Yes	1	7	9
205	R:R:V268	R:R:V319	6.41	No	No	1	6	5
206	R:R:F269	R:R:Y273	6.19	Yes	No	0	9	8
207	R:R:N316	R:R:S272	10.43	No	No	0	9	8
208	R:R:N316	R:R:Y273	27.91	No	No	0	9	8
209	R:R:P275	R:R:T309	5.25	No	No	0	9	7
210	R:R:F276	R:R:H277	11.31	No	Yes	0	7	8
211	R:R:F276	R:R:R310	5.34	No	Yes	0	7	5
212	R:R:A313	R:R:F276	6.93	No	No	0	7	7
213	R:R:M279	R:R:T305	7.53	Yes	No	0	5	4
214	R:R:M279	R:R:T309	9.03	Yes	No	0	5	7
215	R:R:K280	R:R:Y306	8.36	No	Yes	0	6	4
216	R:R:N283	R:R:R287	4.82	No	Yes	2	4	5
217	R:R:N283	R:R:Y306	10.47	No	Yes	2	4	4
218	R:R:D289	R:R:F290	8.36	No	Yes	0	1	3
219	R:R:F290	R:R:M295	9.95	Yes	No	0	3	4
220	R:R:P293	R:R:T292	5.25	No	No	0	1	2
221	R:R:C296	R:R:D300	6.22	No	No	0	4	2
222	R:R:D300	R:R:N299	6.73	No	No	0	2	2
223	R:R:R301	R:R:T305	5.17	No	No	0	2	4
224	R:R:Q307	R:R:Y303	13.53	Yes	Yes	2	5	4
225	R:R:Q307	R:R:Y306	5.64	Yes	Yes	2	5	4
226	R:R:R310	R:R:Y306	19.55	Yes	Yes	2	5	4
227	R:R:Q307	R:R:R310	8.18	Yes	Yes	2	5	5
228	R:R:D320	R:R:N316	6.73	No	No	0	9	9
229	R:R:D320	R:R:Y324	4.6	No	Yes	1	9	9
230	R:R:F325	R:R:F331	6.43	Yes	No	0	6	8
231	R:R:D329	R:R:R332	4.76	No	No	0	5	8
232	R:R:G193	R:R:Y203	4.35	No	No	0	2	4
233	R:R:I259	R:R:L244	4.28	Yes	No	0	6	8
234	R:R:I130	R:R:N134	4.25	No	No	0	4	8
235	R:R:D116	R:R:I200	4.2	No	No	0	5	4
236	R:R:A72	R:R:F325	4.16	No	Yes	0	8	6
237	R:R:D208	R:R:K41	4.15	No	No	0	3	1
238	R:R:L95	R:R:L99	4.15	No	No	0	5	7
239	R:R:H277	R:R:T222	4.11	Yes	No	0	8	5
240	R:R:F62	R:R:V101	3.93	No	No	4	6	5
241	R:R:F66	R:R:V101	3.93	No	No	4	5	5
242	R:R:F98	R:R:I73	3.77	No	No	0	7	7
243	R:R:F215	R:R:M219	3.73	Yes	No	0	4	4
244	R:R:G85	R:R:S84	3.71	No	No	0	6	7
245	R:R:G311	R:R:S314	3.71	No	No	0	4	7
246	R:R:G137	R:R:V179	3.68	No	No	0	6	7
247	R:R:I245	R:R:Y246	3.63	No	No	0	3	5
248	R:R:M279	R:R:Y306	3.59	Yes	Yes	0	5	4
249	R:R:P253	R:R:S252	3.56	No	No	0	4	3
250	R:R:P229	R:R:V228	3.53	No	No	0	9	6
251	R:R:G191	R:R:K125	3.49	No	No	0	4	7
252	R:R:C124	R:R:T192	3.38	No	No	0	9	5
253	R:R:D121	R:R:G120	3.35	No	No	0	3	6
254	R:R:L140	R:R:P229	3.28	No	No	0	5	9
255	R:R:S172	R:R:V88	3.23	No	No	0	7	6
256	R:R:V241	R:R:V262	3.21	No	No	0	5	7
257	R:R:G85	R:R:H148	3.18	No	Yes	0	6	8
258	R:R:I240	R:R:V153	3.07	No	No	0	7	8
259	R:R:I245	R:R:V241	3.07	No	No	0	3	5
260	R:R:M282	R:R:V302	3.04	No	No	0	5	4
261	R:R:F78	R:R:W74	3.01	No	No	0	5	3
262	R:R:L163	R:R:S159	3	No	No	0	8	5
263	R:R:L249	R:R:S252	3	No	No	0	3	3
264	R:R:L315	R:R:V61	2.98	No	No	0	5	6
265	R:R:L177	R:R:V173	2.98	No	No	0	4	4
266	R:R:L323	R:R:V268	2.98	Yes	No	1	7	6
267	R:R:L323	R:R:V319	2.98	Yes	No	1	7	5
268	R:R:I59	R:R:I63	2.94	No	No	0	5	5
269	R:R:I259	R:R:I263	2.94	Yes	No	0	6	4
270	R:R:G48	R:R:Y52	2.9	No	No	0	4	3
271	R:R:M279	R:R:M282	2.89	Yes	No	0	5	5
272	R:R:K81	R:R:M80	2.88	Yes	Yes	1	6	5
273	R:R:I264	R:R:L261	2.85	No	No	0	4	7
274	R:R:I322	R:R:L326	2.85	No	No	0	6	6
275	R:R:P55	R:R:Y111	2.78	No	Yes	0	6	5
276	R:R:A94	R:R:F325	2.77	No	Yes	0	9	6
277	R:R:A286	R:R:F290	2.77	No	Yes	0	1	3
278	R:R:K41	R:R:Q291	2.71	No	No	0	1	2
279	R:R:F49	R:R:V308	2.62	No	No	0	4	5
280	R:R:A96	R:R:W176	2.59	No	No	0	8	9
281	R:R:L239	R:R:R242	2.43	No	No	0	4	5
282	R:R:I200	R:R:W117	2.35	No	Yes	0	4	8
283	R:R:M123	R:R:W117	2.33	No	Yes	0	5	8
284	R:R:F290	R:R:F298	2.14	Yes	No	0	3	1
285	R:R:C318	R:R:G65	1.96	No	No	0	7	8
286	R:R:G152	R:R:S151	1.86	No	No	0	7	5
287	R:R:G191	R:R:T192	1.82	No	No	0	4	5
288	R:R:A147	R:R:C236	1.81	No	No	0	6	6
289	R:R:P185	R:R:S184	1.78	No	No	0	8	4
290	R:R:G120	R:R:M123	1.75	No	No	0	6	5
291	R:R:G68	R:R:L67	1.71	No	No	0	6	4
292	R:R:G235	R:R:L234	1.71	No	No	0	3	4
293	R:R:A243	R:R:V153	1.7	No	No	0	5	8
294	R:R:A243	R:R:V154	1.7	No	No	0	5	7
295	R:R:A286	R:R:V302	1.7	No	No	0	1	4
296	R:R:A294	R:R:T292	1.68	No	No	0	3	2
297	R:R:K81	R:R:P82	1.67	Yes	No	0	6	5
298	R:R:L312	R:R:P275	1.64	No	No	0	7	9
299	R:R:S70	R:R:V71	1.62	No	No	0	3	5
300	R:R:S184	R:R:V180	1.62	No	No	0	4	4
301	R:R:A270	R:R:I274	1.62	No	No	0	5	5
302	R:R:A224	R:R:M225	1.61	No	Yes	0	4	5
303	R:R:T267	R:R:V268	1.59	No	No	0	4	6
304	R:R:I169	R:R:V173	1.54	No	No	0	4	4
305	R:R:I200	R:R:V194	1.54	No	No	0	4	2
306	R:R:M75	R:R:S336	1.53	Yes	No	0	7	5
307	R:R:M75	R:R:V71	1.52	Yes	No	0	7	5
308	R:R:M219	R:R:V223	1.52	No	No	0	4	5
309	R:R:L67	R:R:S70	1.5	No	No	0	4	3
310	R:R:K81	R:R:T330	1.5	Yes	No	0	6	6
311	R:R:L244	R:R:S258	1.5	No	No	0	8	7
312	R:R:I178	R:R:M225	1.46	No	Yes	0	5	5
313	R:R:N197	R:R:T199	1.46	No	No	0	4	4
314	R:R:I322	R:R:L323	1.43	No	Yes	0	6	7
315	R:R:P156	R:R:Y155	1.39	No	Yes	0	8	6
316	R:R:D329	R:R:K257	1.38	No	No	0	5	8
317	R:R:F215	R:R:I216	1.26	Yes	No	0	4	3
318	R:R:I259	R:R:R256	1.25	Yes	No	0	6	5
319	R:R:M80	R:R:R334	1.24	Yes	No	1	5	5
320	R:R:K81	R:R:R334	1.24	Yes	No	1	6	5
321	R:R:K158	R:R:R162	1.24	No	No	0	5	4
322	R:R:K247	R:R:R255	1.24	No	No	0	4	6
323	R:R:F215	R:R:R285	1.07	Yes	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.76111	9	2	0
2	R:R:Q50	8.68667	6	2	4
3	R:R:F51	10.5	4	0	3
4	R:R:L54	5.852	5	2	6
5	R:R:Y58	5.576	5	2	7
6	R:R:M75	5.18167	6	5	7
7	R:R:F76	6.312	5	1	6
8	R:R:M80	4.37	4	1	5
9	R:R:K81	1.8225	4	1	6
10	R:R:W83	8.972	5	1	6
11	R:R:Y89	8.345	4	0	7
12	R:R:M90	5.295	4	1	8
13	R:R:D97	5.25	4	0	9
14	R:R:Y100	10.3125	4	0	7
15	R:R:L107	7.4525	4	0	7
16	R:R:Y110	7.632	5	2	5
17	R:R:Y111	6.23125	8	2	5
18	R:R:W117	5.51	6	2	8
19	R:R:R128	9.752	5	0	5
20	R:R:F131	8.29	4	0	7
21	R:R:H132	6.6275	4	0	5
22	R:R:Y136	6.745	6	0	7
23	R:R:F141	9.7175	4	6	7
24	R:R:L142	7.7575	4	1	8
25	R:R:I145	5.955	4	1	8
26	R:R:H148	7.28	4	0	8
27	R:R:Y150	8.3125	4	7	7
28	R:R:Y155	5.8525	4	7	6
29	R:R:Y189	7.645	6	3	4
30	R:R:Y214	8.765	6	3	4
31	R:R:F215	2.7325	4	0	4
32	R:R:Y217	9.344	5	3	5
33	R:R:M225	3.928	5	0	5
34	R:R:L230	6.875	4	8	6
35	R:R:Y237	6.385	8	1	9
36	R:R:I259	3.59	4	0	6
37	R:R:F269	5.5525	4	0	9
38	R:R:H277	14.235	4	0	8
39	R:R:M279	5.76	4	0	5
40	R:R:R287	6.8725	4	2	5
41	R:R:F290	5.805	4	0	3
42	R:R:Y303	12.7675	4	2	4
43	R:R:Y306	9.522	5	2	4
44	R:R:Q307	9.884	5	2	5
45	R:R:R310	8.47429	7	2	5
46	R:R:L323	3.812	5	1	7
47	R:R:Y324	6.99667	6	1	9
48	R:R:F325	5.236	5	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R287	17.1287	10.62	Yes	Yes	2	0	5
2	R:R:L54	R:R:Y53	15.1139	5.86	Yes	No	0	6	5
3	R:R:V308	R:R:Y53	10.1139	8.83	No	No	0	5	5
4	L:L:?1	R:R:R310	28.7772	8.49	Yes	Yes	2	0	5
5	R:R:L54	R:R:R310	11.5099	4.86	Yes	Yes	2	6	5
6	R:R:F51	R:R:T115	11.901	7.78	Yes	No	0	3	4
7	L:L:?1	R:R:Y110	16.5594	6.83	Yes	Yes	2	0	5
8	R:R:Y111	R:R:Y58	18.9406	4.96	Yes	Yes	2	5	7
9	R:R:L104	R:R:Y58	20.9307	7.03	No	Yes	0	7	7
10	R:R:S314	R:R:Y58	17.2525	6.36	No	Yes	0	7	7
11	R:R:S314	R:R:V61	12.3713	6.46	No	No	0	7	6
12	R:R:F276	R:R:R310	60.2772	5.34	No	Yes	0	7	5
13	R:R:F276	R:R:H277	60.6436	11.31	No	Yes	0	7	8
14	R:R:F226	R:R:H277	97.495	32.81	No	Yes	0	8	8
15	R:R:F226	R:R:L230	95.1535	8.53	No	Yes	8	8	6
16	R:R:F269	R:R:L230	95.396	4.87	Yes	Yes	0	9	6
17	R:R:F269	R:R:L142	56.8416	4.87	Yes	Yes	0	9	8
18	R:R:L142	R:R:Y324	100	7.03	Yes	Yes	1	8	9
19	R:R:I145	R:R:Y324	92.7822	6.04	Yes	Yes	1	8	9
20	R:R:I145	R:R:M90	55.7574	4.37	Yes	Yes	1	8	8
21	R:R:F76	R:R:M90	30.8564	4.98	Yes	Yes	1	6	8
22	R:R:F76	R:R:F91	15.5495	7.5	Yes	No	1	6	5
23	R:R:F91	R:R:I73	13.9109	5.02	No	No	0	5	7
24	R:R:F98	R:R:I73	11.9406	3.77	No	No	0	7	7
25	R:R:L104	R:R:Y100	21.3218	9.38	No	Yes	0	7	7
26	R:R:S317	R:R:Y100	52	5.09	No	Yes	0	9	7
27	R:R:D97	R:R:S317	51.297	4.42	Yes	No	0	9	9
28	R:R:L107	R:R:Y111	22.396	4.69	Yes	Yes	0	7	5
29	R:R:F131	R:R:L107	32.1931	4.87	Yes	Yes	0	7	7
30	R:R:F131	R:R:Y100	34.9109	18.57	Yes	Yes	0	7	7
31	R:R:F325	R:R:M90	27.5446	7.46	Yes	Yes	1	6	8
32	R:R:F325	R:R:F331	23.2079	6.43	Yes	No	0	6	8
33	R:R:F331	R:R:M75	21.3119	6.22	No	Yes	0	8	7
34	R:R:I145	R:R:I86	46.0743	5.89	Yes	No	1	8	7
35	R:R:H148	R:R:I86	48.6733	10.61	Yes	No	0	8	7
36	R:R:H148	R:R:Y89	36.3812	7.62	Yes	Yes	0	8	7
37	R:R:A168	R:R:Y89	30.8861	5.34	No	Yes	0	8	7
38	R:R:A168	R:R:V88	29.0297	5.09	No	No	0	8	6
39	R:R:S172	R:R:V88	21.505	3.23	No	No	0	7	6
40	R:R:F141	R:R:S172	17.6386	5.28	Yes	No	6	7	7
41	R:R:D97	R:R:L93	48.4653	5.43	Yes	No	0	9	9
42	R:R:I130	R:R:T103	20.4455	6.08	No	No	0	4	6
43	R:R:I130	R:R:N134	15.9703	4.25	No	No	0	4	8
44	R:R:F131	R:R:T103	17.995	5.19	Yes	No	0	7	6
45	R:R:K280	R:R:Y306	32.302	8.36	No	Yes	0	6	4
46	R:R:K280	R:R:Y136	20.9851	4.78	No	Yes	0	6	7
47	R:R:R310	R:R:Y306	26.0693	19.55	Yes	Yes	2	5	4
48	R:R:H277	R:R:Y136	41.4554	8.71	Yes	Yes	0	8	7
49	R:R:W117	R:R:Y110	43.7426	5.79	Yes	Yes	2	8	5
50	R:R:I200	R:R:W117	17.302	2.35	No	Yes	0	4	8
51	R:R:R128	R:R:Y110	14.9455	5.14	Yes	Yes	0	5	5
52	R:R:C202	R:R:R128	14.2525	8.36	No	Yes	0	9	5
53	R:R:M123	R:R:W117	17.302	2.33	No	Yes	0	5	8
54	R:R:G120	R:R:M123	12.9901	1.75	No	No	0	6	5
55	R:R:F131	R:R:H132	10.0297	4.53	Yes	Yes	0	7	5
56	R:R:T221	R:R:Y136	20.1782	6.24	No	Yes	0	5	7
57	R:R:M225	R:R:Y136	11.9851	7.18	Yes	Yes	0	5	7
58	R:R:F141	R:R:V175	11.8762	10.49	Yes	No	0	7	7
59	R:R:F269	R:R:I233	36.9158	6.28	Yes	No	0	9	8
60	R:R:I233	R:R:Y237	35.302	4.84	No	Yes	1	8	9
61	R:R:I240	R:R:Y237	20.9653	4.84	No	Yes	0	7	9
62	R:R:I240	R:R:V153	19.198	3.07	No	No	0	7	8
63	R:R:A243	R:R:V153	17.599	1.7	No	No	0	5	8
64	R:R:A243	R:R:V154	15.901	1.7	No	No	0	5	7
65	R:R:V262	R:R:Y237	31.3465	8.83	No	Yes	0	7	9
66	R:R:V241	R:R:V262	29.8515	3.21	No	No	0	5	7
67	R:R:I245	R:R:V241	28.2129	3.07	No	No	0	3	5
68	R:R:I186	R:R:Y217	13.1881	7.25	No	Yes	0	4	5
69	R:R:Y189	R:R:Y217	19.9653	5.96	Yes	Yes	3	4	5
70	R:R:K280	R:R:S218	19.3119	6.12	No	No	0	6	5
71	R:R:S218	R:R:Y214	17.8168	5.09	No	Yes	0	5	4
72	R:R:Y189	R:R:Y210	19.8465	4.96	Yes	No	3	4	4
73	R:R:E209	R:R:Y210	22.5842	21.32	No	No	0	3	4
74	R:R:E209	R:R:S207	20.1139	11.5	No	No	0	3	5
75	R:R:S207	R:R:Y203	17.6337	5.09	No	No	0	5	4
76	R:R:T201	R:R:Y203	12.6436	9.99	No	No	0	3	4
77	R:R:R195	R:R:T201	10.1337	6.47	No	No	0	1	3
78	R:R:L211	R:R:R287	14.2723	7.29	No	Yes	0	4	5
79	R:R:L211	R:R:L288	12.8564	6.92	No	No	0	4	3
80	R:R:V265	R:R:Y324	16.1881	10.09	No	Yes	1	7	9
81	R:R:I245	R:R:I259	21.901	5.89	No	Yes	0	3	6
82	R:R:I259	R:R:L244	14.7475	4.28	Yes	No	0	6	8
83	R:R:L244	R:R:R255	11.1139	19.44	No	No	0	8	6
84	R:R:L323	R:R:V265	22.9851	5.96	Yes	No	1	7	7
85	R:R:M279	R:R:Y306	33.7822	3.59	Yes	Yes	0	5	4
86	R:R:M279	R:R:M282	18.396	2.89	Yes	No	0	5	5
87	R:R:M282	R:R:V302	15.797	3.04	No	No	0	5	4
88	R:R:A286	R:R:V302	13.1881	1.7	No	No	0	1	4
89	R:R:A286	R:R:F290	10.5693	2.77	No	Yes	0	1	3
90	R:R:Y110	R:R:Y111	27.9307	12.91	Yes	Yes	2	5	5
91	R:R:L107	R:R:R128	20.3366	10.93	Yes	Yes	0	7	5
92	R:R:T221	R:R:Y217	18.8713	7.49	No	Yes	0	5	5
93	R:R:R310	R:R:Y111	19.6634	8.23	Yes	Yes	2	5	5
94	R:R:L142	R:R:L93	47.7772	6.92	Yes	No	0	8	9
95	R:R:R149	R:R:Y237	11.0099	9.26	No	Yes	1	9	9
96	R:R:Y237	R:R:Y324	17.698	4.96	Yes	Yes	1	9	9
97	R:R:I145	R:R:R149	10.4158	7.52	Yes	No	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L44	13.71	2	Yes	No	0	2	0	1
L:L:?1	R:R:Q50	8.53	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y110	6.83	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y111	4.78	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:N283	8.8	2	Yes	No	0	4	0	1
L:L:?1	R:R:R287	10.62	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:N299	4.8	2	Yes	No	0	2	0	1
L:L:?1	R:R:Y303	12.29	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:R310	8.49	2	Yes	Yes	0	5	0	1
R:R:C42	R:R:N299	7.87	0	No	No	8	2	2	1
R:R:L44	R:R:Y303	11.72	2	No	Yes	2	4	1	1
R:R:Q50	R:R:Y111	5.64	2	Yes	Yes	4	5	1	1
R:R:Q50	R:R:T115	5.67	2	Yes	No	4	4	1	2
R:R:Q50	R:R:Y303	13.53	2	Yes	Yes	4	4	1	1
R:R:Q307	R:R:Q50	14.08	2	Yes	Yes	5	4	2	1
R:R:Q50	R:R:R310	4.67	2	Yes	Yes	4	5	1	1
R:R:L54	R:R:Y58	4.69	2	Yes	Yes	6	7	2	2
R:R:L54	R:R:Y111	5.86	2	Yes	Yes	6	5	2	1
R:R:L54	R:R:Q307	7.99	2	Yes	Yes	6	5	2	2
R:R:L54	R:R:R310	4.86	2	Yes	Yes	6	5	2	1
R:R:Y111	R:R:Y58	4.96	2	Yes	Yes	5	7	1	2
R:R:L107	R:R:Y111	4.69	0	Yes	Yes	7	5	2	1
R:R:L107	R:R:R128	10.93	0	Yes	Yes	7	5	2	2
R:R:Y110	R:R:Y111	12.91	2	Yes	Yes	5	5	1	1
R:R:T115	R:R:Y110	7.49	0	No	Yes	4	5	2	1
R:R:W117	R:R:Y110	5.79	2	Yes	Yes	8	5	2	1
R:R:R128	R:R:Y110	5.14	0	Yes	Yes	5	5	2	1
R:R:R310	R:R:Y111	8.23	2	Yes	Yes	5	5	1	1
R:R:D208	R:R:R287	4.76	0	No	Yes	3	5	2	1
R:R:L211	R:R:R287	7.29	0	No	Yes	4	5	2	1
R:R:F276	R:R:R310	5.34	0	No	Yes	7	5	2	1
R:R:N283	R:R:R287	4.82	2	No	Yes	4	5	1	1
R:R:N283	R:R:Y306	10.47	2	No	Yes	4	4	1	2
R:R:D300	R:R:N299	6.73	0	No	No	2	2	2	1
R:R:Q307	R:R:Y303	13.53	2	Yes	Yes	5	4	2	1
R:R:Q307	R:R:Y306	5.64	2	Yes	Yes	5	4	2	2
R:R:R310	R:R:Y306	19.55	2	Yes	Yes	5	4	1	2
R:R:Q307	R:R:R310	8.18	2	Yes	Yes	5	5	2	1
R:R:P55	R:R:Y111	2.78	0	No	Yes	6	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WJX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.36
Number of Linked Nodes	276
Number of Links	323
Number of Hubs	48
Number of Links mediated by Hubs	184
Number of Communities	8
Number of Nodes involved in Communities	59
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	59429
Length Of Smallest Path	3
Average Path Length	12.8892
Length of Longest Path	32
Minimum Path Strength	1.165
Average Path Strength	7.33423
Maximum Path Strength	22.415
Minimum Path Correlation	0.7
Average Path Correlation	0.925403
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	49.3358
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.0025
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • oxidoreductase activity • monooxygenase activity • Oplophorus-luciferin 2-monooxygenase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen • luciferin monooxygenase activity • A1 adenosine receptor binding • signaling receptor binding • G protein-coupled receptor binding • adenosine receptor binding • adenyl ribonucleotide binding • nucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • adenyl nucleotide binding • ATP binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • ADP binding • G protein-coupled purinergic nucleotide receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled ATP receptor activity • protein heterodimerization activity • protein dimerization activity • scaffold protein binding • G protein-coupled ADP receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • bioluminescence • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • positive regulation of biological process • mating behavior • behavior • positive regulation of penile erection • positive regulation of multicellular organismal process • reproductive behavior • regulation of multicellular organismal process • penile erection • copulation • positive regulation of reproductive process • positive regulation of cell communication • regulation of localization • regulation of hormone secretion • transport • positive regulation of secretion by cell • hormone secretion • localization • positive regulation of hormone secretion • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • regulation of biological quality • positive regulation of cellular process • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • positive regulation of transport • regulation of cell communication • hormone transport • positive regulation of signaling • monoatomic ion transport • protein localization • protein localization to cell periphery • cellular localization • protein localization to plasma membrane • cellular macromolecule localization • macromolecule localization • localization within membrane • protein localization to membrane • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • signal transduction involved in regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of metabolic process • cellular response to ATP • response to organophosphorus • response to ATP • response to purine-containing compound • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of inositol phosphate biosynthetic process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of inositol trisphosphate biosynthetic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • positive regulation of phosphorus metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of carbohydrate metabolic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulated exocytosis • modulation of chemical synaptic transmission • synaptic vesicle cycle • synaptic vesicle exocytosis • vesicle-mediated transport • vesicle-mediated transport in synapse • regulation of regulated secretory pathway • establishment of localization in cell • trans-synaptic signaling • neurotransmitter secretion • regulation of neurotransmitter transport • regulation of synaptic vesicle exocytosis • neurotransmitter transport • regulation of vesicle-mediated transport • chemical synaptic transmission • signal release from synapse • regulation of trans-synaptic signaling • exocytosis • regulation of neurotransmitter secretion • anterograde trans-synaptic signaling • regulation of exocytosis • regulation of monoatomic ion transport • positive regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • eating behavior • feeding behavior • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • cellular response to purine-containing compound • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • response to growth factor • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular developmental process • glial cell migration • nervous system development • neurogenesis • gliogenesis • cell differentiation • cell migration • cell motility • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • blood circulation • regulation of anatomical structure size • monoamine transport • nitrogen compound transport • negative regulation of amine transport • regulation of catecholamine secretion • negative regulation of biological process • negative regulation of transport • organic hydroxy compound transport • negative regulation of secretion • catecholamine transport • negative regulation of cellular process • negative regulation of norepinephrine secretion • negative regulation of secretion by cell • norepinephrine transport • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • muscle system process • relaxation of muscle • periplasmic space • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • somatodendritic compartment • dendrite • dendritic tree • glutamatergic synapse • cell body • apical part of cell • apical plasma membrane • cell surface • presynaptic active zone membrane • presynaptic membrane • presynapse • presynaptic active zone • postsynaptic density • neuron to neuron synapse • postsynaptic specialization • asymmetric synapse
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ADP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ADP
Name	Adenosine disphosphate
Synonyms	Adenosine disphosphate ADP
Identifier
Formula	C10 H15 N5 O10 P2
Molecular Weight	427.201
SMILES
PubChem	6022
Formal Charge	0
Total Atoms	42
Total Chiral Atoms	5
Total Bonds	44
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47900
Sequence	>8WJX_nogp_Chain_R F K C A L T K T G F Q F Y Y L P A V Y I L V F I I G F L G N S V A I W M F V F H M K P W S G I S V Y M F N L A L A D F L Y V L T L P A L I F Y Y F N K T D W I F G D A M C K L Q R F I F H V N L Y G S I L F L T C I S A H R Y S G V V Y P L K S L G R L K K K N A I C I S V L V W L I V V V A I S P I L F Y S G T G V R K N K T I T C Y D T T S D E Y L R S Y F I Y S M C T T V A M F C V P L V L I L G C Y G L I V R A L I Y K D L D N S P L R R K S I Y L V I I V L T V F A V S Y I P F H V M K T M N L R A R L D F Q T P A M C A F N D R V Y A T Y Q V T R G L A S L N S C V D P I L Y F L A G D T F R R R L S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WJX	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-	chim(Gs-CtGq)/β1/γ2	3.2	2024-10-02	To be published
	8WJX (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-		3.2	2024-10-02	To be published
	8KGG	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-	chim(NtGi2-G13)/β1/γ2	3.06	2024-07-31	To be published
	8KGG (No Gprot)	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-		3.06	2024-07-31	To be published
	7XXH	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-	chim(NtGi1-G11)/β1/γ2	2.9	2023-06-07	10.1093/procel/pwac025
	7XXH (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-		2.9	2023-06-07	10.1093/procel/pwac025
	4XNW	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	MRS2500	-	-	2.7	2015-04-01	10.1038/nature14287
	4XNV	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	-	BPTU	-	2.2	2015-04-01	10.1038/nature14287

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