psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C25	R:R:C277	7.28	No	No	0	8	7
2	R:R:T28	R:R:Y285	13.73	No	No	0	2	3
3	R:R:Q33	R:R:V30	2.87	Yes	No	0	5	3
4	R:R:F32	R:R:Y285	4.13	No	No	0	5	3
5	R:R:Q33	R:R:Y34	4.51	Yes	Yes	1	5	4
6	R:R:Q33	R:R:Y37	9.02	Yes	Yes	1	5	6
7	R:R:P288	R:R:Q33	4.74	Yes	Yes	1	5	5
8	R:R:Y34	R:R:Y94	9.93	Yes	Yes	1	4	5
9	R:R:H97	R:R:Y34	4.36	No	Yes	0	4	4
10	R:R:A183	R:R:Y34	2.67	No	Yes	1	5	4
11	R:R:L36	R:R:T40	2.95	Yes	No	1	4	6
12	R:R:F289	R:R:L36	6.09	No	Yes	0	5	4
13	R:R:C292	R:R:L36	4.76	No	Yes	1	5	4
14	R:R:Y37	R:R:Y41	3.97	Yes	Yes	1	6	8
15	R:R:Y37	R:R:Y94	8.94	Yes	Yes	1	6	5
16	R:R:P288	R:R:Y37	8.34	Yes	Yes	1	5	6
17	R:R:L291	R:R:Y37	4.69	No	Yes	1	6	6
18	L:L:?1	R:R:Y37	3.61	Yes	Yes	1	0	6
19	R:R:L43	R:R:T39	2.95	No	No	0	5	5
20	R:R:I44	R:R:T40	3.04	No	No	0	7	6
21	R:R:C292	R:R:T40	10.14	No	No	1	5	6
22	R:R:L87	R:R:Y41	8.21	No	Yes	0	8	8
23	R:R:R90	R:R:Y41	5.14	Yes	Yes	1	6	8
24	L:L:?1	R:R:Y41	4.51	Yes	Yes	1	0	8
25	R:R:I42	R:R:I91	5.89	No	No	0	5	7
26	R:R:I44	R:R:L296	2.85	No	No	0	7	5
27	R:R:F45	R:R:I46	3.77	Yes	No	0	7	5
28	R:R:F45	R:R:L49	8.53	Yes	No	0	7	6
29	R:R:F45	R:R:L87	2.44	Yes	No	0	7	8
30	R:R:F45	R:R:P88	7.22	Yes	No	0	7	9
31	R:R:I46	R:R:P47	3.39	No	No	0	5	5
32	R:R:L299	R:R:P47	4.93	No	No	0	7	5
33	R:R:L49	R:R:V84	5.96	No	No	0	6	5
34	R:R:L49	R:R:L85	2.77	No	No	0	6	5
35	R:R:D80	R:R:N52	2.69	Yes	No	0	9	9
36	R:R:L81	R:R:N52	2.75	No	No	0	7	9
37	R:R:N52	R:R:P302	8.15	No	No	0	9	9
38	R:R:A55	R:R:Y306	4	No	Yes	0	8	7
39	R:R:A55	R:R:F307	2.77	No	Yes	0	8	7
40	R:R:L56	R:R:S77	3	No	No	0	7	8
41	R:R:R61	R:R:W57	6	No	No	0	4	3
42	R:R:R61	R:R:V58	3.92	No	No	0	4	7
43	R:R:F62	R:R:V58	3.93	No	No	0	5	7
44	R:R:I70	R:R:L59	2.85	Yes	No	0	7	6
45	R:R:I74	R:R:L59	2.85	No	No	0	7	6
46	R:R:F62	R:R:K65	3.72	No	No	0	5	5
47	R:R:F62	R:R:I70	3.77	No	Yes	0	5	7
48	R:R:K65	R:R:N67	6.99	No	No	0	5	7
49	R:R:I70	R:R:N67	7.08	Yes	No	0	7	7
50	R:R:K68	R:R:R146	3.71	No	No	0	6	6
51	R:R:A69	R:R:Q130	6.06	No	No	0	8	8
52	R:R:I71	R:R:R146	3.76	No	No	0	6	6
53	R:R:D149	R:R:I71	2.8	No	No	0	7	6
54	R:R:C126	R:R:F72	6.98	No	Yes	0	6	7
55	R:R:F72	R:R:Q130	7.03	Yes	No	0	7	8
56	R:R:D149	R:R:F72	8.36	No	Yes	0	7	7
57	R:R:F123	R:R:N75	13.29	Yes	No	2	7	9
58	R:R:N75	R:R:S153	10.43	No	No	2	9	6
59	R:R:N75	R:R:W157	5.65	No	Yes	2	9	9
60	R:R:D80	R:R:L76	2.71	Yes	Yes	2	9	9
61	R:R:L76	R:R:S120	3	Yes	No	2	9	9
62	R:R:F123	R:R:L76	2.44	Yes	Yes	2	7	9
63	R:R:L124	R:R:L76	5.54	Yes	Yes	0	8	9
64	R:R:S77	R:R:Y306	2.54	No	Yes	0	8	7
65	R:R:D80	R:R:S120	7.36	Yes	No	2	9	9
66	R:R:C298	R:R:D80	4.67	No	Yes	0	8	9
67	R:R:D301	R:R:D80	2.66	No	Yes	0	9	9
68	R:R:A82	R:R:N116	4.69	No	No	0	7	8
69	R:R:H83	R:R:K113	6.55	Yes	No	0	7	6
70	R:R:H83	R:R:N116	3.83	Yes	No	0	7	8
71	R:R:H83	R:R:M117	3.94	Yes	No	0	7	8
72	R:R:C298	R:R:H83	7.37	No	Yes	0	8	7
73	R:R:R90	R:R:S86	5.27	Yes	No	0	6	6
74	R:R:L89	R:R:W99	3.42	No	Yes	1	6	8
75	R:R:C109	R:R:L89	3.17	No	No	1	5	6
76	R:R:F182	R:R:L89	2.44	Yes	No	1	4	6
77	R:R:R90	R:R:Y94	3.09	Yes	Yes	1	6	5
78	R:R:K113	R:R:R90	11.14	No	Yes	0	6	6
79	R:R:F182	R:R:R90	11.76	Yes	Yes	1	4	6
80	L:L:?1	R:R:R90	14.96	Yes	Yes	1	0	6
81	R:R:S96	R:R:Y92	12.72	No	No	0	4	4
82	R:R:P100	R:R:Y92	4.17	No	No	0	4	4
83	R:R:C181	R:R:Y93	4.03	Yes	No	0	9	5
84	R:R:D184	R:R:Y93	4.6	No	No	0	5	5
85	R:R:A183	R:R:Y94	4	No	Yes	1	5	5
86	L:L:?1	R:R:Y94	5.41	Yes	Yes	1	0	5
87	R:R:H98	R:R:P100	6.1	No	No	0	4	4
88	R:R:H98	R:R:K179	9.17	No	No	0	4	4
89	R:R:F101	R:R:W99	5.01	No	Yes	0	7	8
90	R:R:C106	R:R:W99	3.92	No	Yes	1	9	8
91	R:R:C181	R:R:W99	13.06	Yes	Yes	1	9	8
92	R:R:F101	R:R:P100	7.22	No	No	0	7	4
93	R:R:C106	R:R:C181	7.28	No	Yes	1	9	9
94	R:R:C106	R:R:F182	5.59	No	Yes	1	9	4
95	R:R:L107	R:R:P168	3.28	No	No	0	8	5
96	R:R:C109	R:R:F182	4.19	No	Yes	1	5	4
97	R:R:F110	R:R:R171	4.28	No	Yes	1	5	4
98	R:R:F110	R:R:F182	3.22	No	Yes	1	5	4
99	L:L:?1	R:R:F110	4.69	Yes	No	1	0	5
100	R:R:L115	R:R:Y111	3.52	No	No	0	5	5
101	R:R:P168	R:R:Y111	9.74	No	No	0	5	5
102	R:R:K113	R:R:S295	3.06	No	No	0	6	7
103	R:R:F167	R:R:Y114	3.09	No	No	1	4	5
104	L:L:?1	R:R:Y114	12.63	Yes	No	1	0	5
105	R:R:L115	R:R:N116	4.12	No	No	0	5	8
106	R:R:H260	R:R:Y118	6.53	No	No	0	8	7
107	L:L:?1	R:R:Y118	5.41	Yes	No	0	0	7
108	R:R:A119	R:R:W157	3.89	No	Yes	0	6	9
109	R:R:I121	R:R:P210	3.39	No	No	0	8	9
110	R:R:F256	R:R:I121	8.79	No	No	0	9	8
111	R:R:C122	R:R:I156	3.27	No	No	0	6	7
112	L:L:?1	R:R:C122	2.44	Yes	No	0	0	6
113	R:R:F123	R:R:S153	3.96	Yes	No	2	7	6
114	R:R:F123	R:R:I156	6.28	Yes	No	0	7	7
115	R:R:F123	R:R:W157	5.01	Yes	Yes	2	7	9
116	R:R:F252	R:R:L124	2.44	No	Yes	0	9	8
117	R:R:D301	R:R:L124	6.79	No	Yes	0	9	8
118	R:R:L124	R:R:Y305	3.52	Yes	Yes	0	8	9
119	R:R:P210	R:R:T125	3.5	No	No	0	9	7
120	R:R:I213	R:R:T125	4.56	No	No	0	6	7
121	R:R:I127	R:R:R131	2.51	No	No	3	8	9
122	R:R:I127	R:R:Y305	3.63	No	Yes	3	8	9
123	R:R:I214	R:R:S128	3.1	No	No	0	8	9
124	R:R:F133	R:R:L129	4.87	No	No	0	5	6
125	R:R:C217	R:R:L129	3.17	No	No	0	6	6
126	R:R:F134	R:R:Q130	4.68	No	No	0	8	8
127	R:R:R131	R:R:Y305	4.12	No	Yes	3	9	9
128	R:R:C132	R:R:C217	3.64	No	No	0	7	6
129	R:R:C132	R:R:K220	3.23	No	Yes	0	7	4
130	R:R:C132	R:R:T221	3.38	No	No	0	7	8
131	R:R:F133	R:R:R140	3.21	No	No	0	5	5
132	R:R:A141	R:R:F134	4.16	No	No	0	6	8
133	R:R:K220	R:R:L136	7.05	Yes	No	0	4	7
134	R:R:L136	R:R:S224	3	No	No	0	7	5
135	R:R:F139	R:R:R142	4.28	No	No	0	5	5
136	R:R:W144	R:R:Y148	8.68	No	No	0	4	4
137	R:R:D149	R:R:W144	10.05	No	No	0	7	4
138	R:R:K145	R:R:R147	2.48	No	No	5	7	5
139	R:R:K145	R:R:Y148	13.14	No	No	5	7	4
140	R:R:R147	R:R:Y148	6.17	No	No	5	5	4
141	R:R:I152	R:R:I156	2.94	No	No	0	5	7
142	R:R:S153	R:R:W157	2.47	No	Yes	2	6	9
143	L:L:?1	R:R:V160	5.73	Yes	No	0	0	8
144	R:R:M198	R:R:P166	3.35	No	No	1	5	8
145	L:L:?1	R:R:P166	2.53	Yes	No	1	0	8
146	L:L:?1	R:R:F167	14.06	Yes	No	1	0	4
147	R:R:L170	R:R:M190	5.65	No	No	0	4	4
148	R:R:L185	R:R:R171	4.86	No	Yes	1	5	4
149	R:R:R171	R:R:Y187	25.72	Yes	No	0	4	5
150	L:L:?1	R:R:R171	6.54	Yes	Yes	1	0	4
151	R:R:K188	R:R:S172	3.06	No	No	0	2	5
152	R:R:D174	R:R:T173	5.78	Yes	Yes	1	1	5
153	R:R:L185	R:R:T173	4.42	No	Yes	1	5	5
154	R:R:G186	R:R:T173	5.46	No	Yes	0	5	5
155	R:R:K188	R:R:T173	4.5	No	Yes	0	2	5
156	R:R:D174	R:R:N177	5.39	Yes	No	1	1	6
157	R:R:D174	R:R:S180	10.31	Yes	No	1	1	3
158	R:R:D174	R:R:L185	5.43	Yes	No	1	1	5
159	R:R:N176	R:R:N177	8.17	No	No	0	8	6
160	R:R:N177	R:R:S180	2.98	No	No	1	6	3
161	R:R:D184	R:R:S180	7.36	No	No	0	5	3
162	R:R:C181	R:R:F182	8.38	Yes	Yes	1	9	4
163	L:L:?1	R:R:F182	2.81	Yes	Yes	1	0	4
164	R:R:K270	R:R:Y187	13.14	No	No	0	3	5
165	R:R:E271	R:R:Y187	11.22	Yes	No	0	1	5
166	R:R:N191	R:R:V193	2.96	No	No	0	3	1
167	R:R:L195	R:R:M268	4.24	No	Yes	0	4	4
168	R:R:E271	R:R:L195	5.3	Yes	No	0	1	4
169	L:L:?1	R:R:M198	4.35	Yes	No	1	0	5
170	R:R:F263	R:R:I199	6.28	Yes	Yes	6	7	5
171	R:R:I199	R:R:T267	4.56	Yes	No	6	5	5
172	R:R:I199	R:R:M268	2.92	Yes	Yes	0	5	4
173	L:L:?1	R:R:A202	4.85	Yes	No	0	0	6
174	R:R:L204	R:R:V208	4.47	No	No	0	4	4
175	R:R:F207	R:R:V211	5.24	No	No	0	8	6
176	R:R:F207	R:R:T257	6.49	No	No	0	8	6
177	R:R:F207	R:R:H260	11.31	No	No	0	8	8
178	R:R:I212	R:R:V208	3.07	No	No	0	3	4
179	R:R:I209	R:R:P210	3.39	No	No	0	6	9
180	R:R:F253	R:R:V211	6.55	No	No	0	5	6
181	R:R:F252	R:R:I214	7.54	No	No	0	9	8
182	R:R:C217	R:R:W216	2.61	No	No	0	6	4
183	R:R:K220	R:R:W216	8.12	Yes	No	0	4	4
184	R:R:F246	R:R:T218	2.59	No	No	0	4	9
185	R:R:K220	R:R:W219	3.48	Yes	No	4	4	3
186	R:R:I223	R:R:W219	14.09	No	No	4	4	3
187	R:R:I223	R:R:K220	2.91	No	Yes	4	4	4
188	R:R:L242	R:R:T222	5.9	Yes	No	7	6	5
189	R:R:F246	R:R:T222	6.49	No	No	7	4	5
190	R:R:I223	R:R:Q227	4.12	No	No	0	4	4
191	R:R:L225	R:R:R238	6.07	No	No	0	8	7
192	R:R:L225	R:R:L242	2.77	No	Yes	0	8	6
193	R:R:L242	R:R:R226	7.29	Yes	No	0	6	5
194	R:R:P228	R:R:R238	4.32	No	No	0	6	7
195	R:R:M230	R:R:R238	6.2	No	No	0	2	7
196	R:R:F246	R:R:L242	4.87	No	Yes	7	4	6
197	R:R:M244	R:R:M308	2.89	No	No	0	7	7
198	R:R:L304	R:R:M247	5.65	No	No	0	7	5
199	R:R:M247	R:R:M308	2.89	No	No	0	5	7
200	R:R:C248	R:R:L304	4.76	No	No	0	8	7
201	R:R:C248	R:R:Y305	5.38	No	Yes	0	8	9
202	R:R:L304	R:R:V251	5.96	No	No	0	7	6
203	R:R:F253	R:R:T257	2.59	No	No	0	5	6
204	R:R:C297	R:R:F256	5.59	No	No	0	9	9
205	R:R:P258	R:R:T257	3.5	No	No	0	9	6
206	R:R:L293	R:R:P258	3.28	No	No	0	8	9
207	R:R:F263	R:R:Y259	6.19	Yes	No	0	7	7
208	R:R:C290	R:R:Y259	2.69	No	No	0	6	7
209	R:R:A294	R:R:Y259	4	No	No	0	8	7
210	R:R:H287	R:R:N262	3.83	Yes	Yes	0	5	5
211	R:R:C290	R:R:N262	3.15	No	Yes	0	6	5
212	R:R:F263	R:R:T267	6.49	Yes	No	6	7	5
213	R:R:F265	R:R:I264	2.51	No	No	0	5	6
214	R:R:K270	R:R:Y266	9.55	No	No	0	3	5
215	R:R:H287	R:R:Y266	30.49	Yes	No	1	5	5
216	L:L:?1	R:R:Y266	7.22	Yes	No	1	0	5
217	R:R:I273	R:R:M268	2.92	No	Yes	0	1	4
218	R:R:I274	R:R:M268	2.92	No	Yes	0	3	4
219	R:R:I274	R:R:V269	6.14	No	No	0	3	2
220	R:R:V269	R:R:V280	6.41	No	No	0	2	3
221	R:R:E271	R:R:I273	2.73	Yes	No	0	1	1
222	R:R:P278	R:R:S276	5.34	No	No	0	2	4
223	R:R:S276	R:R:V279	3.23	No	No	0	4	1
224	R:R:C277	R:R:R281	2.79	No	No	0	7	4
225	R:R:L284	R:R:V280	2.98	No	No	0	4	3
226	R:R:F286	R:R:I282	3.77	No	No	0	4	3
227	R:R:H287	R:R:P288	3.05	Yes	Yes	1	5	5
228	R:R:H287	R:R:L291	7.71	Yes	No	1	5	6
229	L:L:?1	R:R:H287	8.9	Yes	Yes	1	0	5
230	L:L:?1	R:R:L291	9.59	Yes	No	1	0	6
231	R:R:P302	R:R:Y306	2.78	No	Yes	0	9	7
232	R:R:F307	R:R:I303	2.51	Yes	No	0	7	6
233	R:R:Y305	R:R:Y306	2.98	Yes	Yes	0	9	7
234	R:R:F307	R:R:F312	3.22	Yes	No	0	7	8
235	R:R:A309	R:R:E311	3.02	No	No	0	7	7
236	R:R:A309	R:R:F312	2.77	No	No	0	7	8
237	R:R:F312	R:R:R313	8.55	No	No	0	8	8
238	R:R:L107	R:R:R103	2.43	No	No	0	8	4
239	R:R:I91	R:R:Y41	2.42	No	Yes	0	7	8
240	R:R:I121	R:R:Y118	2.42	No	No	0	8	7
241	R:R:M73	R:R:Y306	2.39	No	Yes	0	8	7
242	R:R:L59	R:R:Y306	2.34	No	Yes	0	6	7
243	R:R:E203	R:R:F263	2.33	No	Yes	0	5	7
244	R:R:L105	R:R:W99	2.28	No	Yes	0	5	8
245	R:R:F289	R:R:F32	2.14	No	No	0	5	5
246	R:R:F123	R:R:F72	2.14	Yes	Yes	0	7	7
247	R:R:R140	R:R:W144	2	No	No	0	5	4
248	R:R:P228	R:R:P229	1.95	No	No	0	6	4
249	R:R:C277	R:R:P278	1.88	No	No	0	7	2
250	R:R:G197	R:R:V196	1.84	No	No	0	3	3
251	R:R:G197	R:R:T200	1.82	No	No	0	3	4
252	R:R:A119	R:R:A79	1.79	No	No	0	6	8
253	R:R:G48	R:R:L299	1.71	No	No	0	8	7
254	R:R:G161	R:R:L115	1.71	No	No	0	4	5
255	R:R:C164	R:R:V160	1.71	No	No	0	7	8
256	R:R:C255	R:R:V251	1.71	No	No	0	7	6
257	R:R:A249	R:R:T218	1.68	No	No	0	7	9
258	R:R:K137	R:R:P138	1.67	No	No	0	6	8
259	R:R:L36	R:R:P288	1.64	Yes	Yes	1	4	5
260	R:R:C298	R:R:I44	1.64	No	No	0	8	7
261	R:R:C60	R:R:I74	1.64	No	No	0	3	7
262	R:R:L165	R:R:P166	1.64	No	No	0	4	8
263	R:R:V279	R:R:V280	1.6	No	No	0	1	3
264	R:R:T218	R:R:V245	1.59	No	No	0	9	7
265	R:R:C255	R:R:L300	1.59	No	No	0	7	7
266	R:R:A241	R:R:L225	1.58	No	No	0	7	8
267	R:R:P228	R:R:Q227	1.58	No	No	0	6	4
268	R:R:A192	R:R:N191	1.56	No	No	0	2	3
269	R:R:A194	R:R:N191	1.56	No	No	0	3	3
270	R:R:A283	R:R:N262	1.56	No	Yes	0	4	5
271	R:R:K65	R:R:S64	1.53	No	No	0	5	6
272	R:R:K240	R:R:S310	1.53	No	No	0	7	5
273	R:R:M268	R:R:V196	1.52	Yes	No	0	4	3
274	R:R:I199	R:R:T200	1.52	Yes	No	0	5	4
275	R:R:L112	R:R:S86	1.5	No	No	0	5	6
276	R:R:I63	R:R:I70	1.47	No	Yes	0	5	7
277	R:R:L135	R:R:T221	1.47	No	No	0	8	8
278	R:R:I199	R:R:I264	1.47	Yes	No	0	5	6
279	R:R:E237	R:R:S236	1.44	No	No	0	5	4
280	R:R:I46	R:R:L50	1.43	No	No	0	5	4
281	R:R:I169	R:R:L165	1.43	No	No	0	4	4
282	R:R:A51	R:R:F307	1.39	No	Yes	0	7	7
283	R:R:A38	R:R:Y94	1.33	No	Yes	0	5	5
284	R:R:E271	R:R:L170	1.33	Yes	No	0	1	4
285	R:R:K240	R:R:R243	1.24	No	No	0	7	7
286	R:R:V78	R:R:W157	1.23	No	Yes	0	5	9
287	R:R:L175	R:R:R103	1.21	No	No	0	1	4
288	R:R:N178	R:R:R103	1.21	No	No	0	1	4
289	L:L:?1	R:R:A163	1.21	Yes	No	0	0	5
290	L:L:?1	R:R:A205	1.21	Yes	No	0	0	4
291	R:R:F286	R:R:N262	1.21	No	Yes	0	4	5
292	R:R:D143	R:R:R142	1.19	No	No	0	5	5
293	L:L:?1	R:R:V159	1.15	Yes	No	0	0	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q33	5.285	4	1	5
2	R:R:Y34	5.3675	4	1	4
3	R:R:L36	3.86	4	1	4
4	R:R:Y37	6.42833	6	1	6
5	R:R:Y41	4.85	5	1	8
6	R:R:F45	5.49	4	0	7
7	R:R:I70	3.7925	4	0	7
8	R:R:F72	6.1275	4	0	7
9	R:R:L76	3.4225	4	2	9
10	R:R:D80	4.018	5	2	9
11	R:R:H83	5.4225	4	0	7
12	R:R:R90	8.56	6	1	6
13	R:R:Y94	5.45	6	1	5
14	R:R:W99	5.538	5	1	8
15	R:R:F123	5.52	6	2	7
16	R:R:L124	4.5725	4	0	8
17	R:R:W157	3.65	5	2	9
18	R:R:R171	10.35	4	1	4
19	R:R:T173	5.04	4	1	5
20	R:R:D174	6.7275	4	1	1
21	R:R:C181	8.1875	4	1	9
22	R:R:F182	5.48429	7	1	4
23	R:R:I199	3.35	5	6	5
24	R:R:K220	4.958	5	4	4
25	R:R:L242	5.2075	4	7	6
26	R:R:N262	2.4375	4	0	5
27	R:R:F263	5.3225	4	6	7
28	R:R:M268	2.904	5	0	4
29	R:R:E271	5.145	4	0	1
30	R:R:H287	10.796	5	1	5
31	R:R:P288	4.4425	4	1	5
32	R:R:Y305	3.926	5	3	9
33	R:R:Y306	2.83833	6	0	7
34	R:R:F307	2.4725	4	0	7
35	L:L:?1	5.89571	21	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C277	R:R:P278	10.3582	1.88	No	No	0	7	2
2	R:R:P278	R:R:S276	13.7915	5.34	No	No	0	2	4
3	R:R:S276	R:R:V279	17.214	3.23	No	No	0	4	1
4	R:R:V279	R:R:V280	20.626	1.6	No	No	0	1	3
5	R:R:V269	R:R:V280	27.4179	6.41	No	No	0	2	3
6	R:R:I274	R:R:V269	30.7979	6.14	No	No	0	3	2
7	R:R:I274	R:R:M268	34.1672	2.92	No	Yes	0	3	4
8	R:R:L195	R:R:M268	27.173	4.24	No	Yes	0	4	4
9	R:R:E271	R:R:L195	28.7007	5.3	Yes	No	0	1	4
10	R:R:E271	R:R:Y187	61.2551	11.22	Yes	No	0	1	5
11	R:R:R171	R:R:Y187	60.3769	25.72	Yes	No	0	4	5
12	L:L:?1	R:R:R171	63.9378	6.54	Yes	Yes	1	0	4
13	L:L:?1	R:R:Y37	11.0289	3.61	Yes	Yes	1	0	6
14	R:R:L36	R:R:P288	18.401	1.64	Yes	Yes	1	4	5
15	R:R:F289	R:R:L36	12.3703	6.09	No	Yes	0	5	4
16	R:R:I273	R:R:M268	27.0027	2.92	No	Yes	0	1	4
17	R:R:E271	R:R:I273	28.5304	2.73	Yes	No	0	1	1
18	L:L:?1	R:R:H287	25.8477	8.9	Yes	Yes	1	0	5
19	R:R:H287	R:R:P288	11.508	3.05	Yes	Yes	1	5	5
20	R:R:I199	R:R:M268	13.6158	2.92	Yes	Yes	0	5	4
21	R:R:F263	R:R:Y259	11.0023	6.19	Yes	No	0	7	7
22	R:R:C290	R:R:Y259	13.5147	2.69	No	No	0	6	7
23	R:R:C290	R:R:N262	14.7975	3.15	No	Yes	0	6	5
24	R:R:H287	R:R:N262	20.0458	3.83	Yes	Yes	0	5	5
25	L:L:?1	R:R:Y41	18.2467	4.51	Yes	Yes	1	0	8
26	L:L:?1	R:R:R90	15.4415	14.96	Yes	Yes	1	0	6
27	R:R:K113	R:R:R90	27.9076	11.14	No	Yes	0	6	6
28	R:R:H83	R:R:K113	26.9495	6.55	Yes	No	0	7	6
29	R:R:C298	R:R:H83	25.0333	7.37	No	Yes	0	8	7
30	R:R:L87	R:R:Y41	21.0145	8.21	No	Yes	0	8	8
31	R:R:F45	R:R:L87	19.1569	2.44	Yes	No	0	7	8
32	R:R:C298	R:R:D80	30.09	4.67	No	Yes	0	8	9
33	L:L:?1	R:R:C122	100	2.44	Yes	No	0	0	6
34	R:R:C122	R:R:I156	99.7871	3.27	No	No	0	6	7
35	R:R:F123	R:R:I156	99.2229	6.28	Yes	No	0	7	7
36	R:R:F123	R:R:L76	64.7203	2.44	Yes	Yes	2	7	9
37	R:R:D80	R:R:L76	15.7183	2.71	Yes	Yes	2	9	9
38	R:R:D80	R:R:N52	17.3684	2.69	Yes	No	0	9	9
39	R:R:N52	R:R:P302	13.7276	8.15	No	No	0	9	9
40	R:R:A55	R:R:Y306	14.5579	4	No	Yes	0	8	7
41	R:R:Y305	R:R:Y306	33.2251	2.98	Yes	Yes	0	9	7
42	R:R:L124	R:R:Y305	48.1343	3.52	Yes	Yes	0	8	9
43	R:R:L124	R:R:L76	51.8869	5.54	Yes	Yes	0	8	9
44	R:R:A55	R:R:F307	12.7748	2.77	No	Yes	0	8	7
45	R:R:L59	R:R:Y306	25.0333	2.34	No	Yes	0	6	7
46	R:R:I70	R:R:L59	19.8435	2.85	Yes	No	0	7	6
47	R:R:F62	R:R:I70	10.9065	3.77	No	Yes	0	5	7
48	R:R:F123	R:R:F72	79.5603	2.14	Yes	Yes	0	7	7
49	R:R:D149	R:R:F72	73.4178	8.36	No	Yes	0	7	7
50	R:R:H83	R:R:N116	16.9213	3.83	Yes	No	0	7	8
51	R:R:F182	R:R:L89	17.2779	2.44	Yes	No	1	4	6
52	L:L:?1	R:R:F182	39.506	2.81	Yes	Yes	1	0	4
53	R:R:L89	R:R:W99	15.5746	3.42	No	Yes	1	6	8
54	R:R:C106	R:R:F182	17.4057	5.59	No	Yes	1	9	4
55	R:R:C106	R:R:W99	15.5001	3.92	No	Yes	1	9	8
56	R:R:C181	R:R:F182	20.8974	8.38	Yes	Yes	1	9	4
57	R:R:C181	R:R:W99	15.9525	13.06	Yes	Yes	1	9	8
58	R:R:F101	R:R:W99	35.285	5.01	No	Yes	0	7	8
59	R:R:F101	R:R:P100	29.4299	7.22	No	No	0	7	4
60	R:R:P100	R:R:Y92	11.8007	4.17	No	No	0	4	4
61	R:R:L185	R:R:R171	15.1009	4.86	No	Yes	1	5	4
62	R:R:H98	R:R:P100	11.8007	6.1	No	No	0	4	4
63	R:R:L115	R:R:N116	13.6211	4.12	No	No	0	5	8
64	R:R:L115	R:R:Y111	10.2784	3.52	No	No	0	5	5
65	L:L:?1	R:R:Y118	25.1397	5.41	Yes	No	0	0	7
66	R:R:H260	R:R:Y118	12.9079	6.53	No	No	0	8	7
67	R:R:I121	R:R:Y118	11.4707	2.42	No	No	0	8	7
68	R:R:D149	R:R:W144	68.9839	10.05	No	No	0	7	4
69	R:R:R140	R:R:W144	64.5499	2	No	No	0	5	4
70	R:R:F133	R:R:R140	63.3789	3.21	No	No	0	5	5
71	R:R:F133	R:R:L129	62.1973	4.87	No	No	0	5	6
72	R:R:C217	R:R:L129	61.0049	3.17	No	No	0	6	6
73	R:R:C132	R:R:C217	31.3461	3.64	No	No	0	7	6
74	R:R:C132	R:R:K220	27.354	3.23	No	Yes	0	7	4
75	R:R:C217	R:R:W216	28.4825	2.61	No	No	0	6	4
76	R:R:K220	R:R:W216	27.1518	8.12	Yes	No	0	4	4
77	R:R:F207	R:R:H260	11.4707	11.31	No	No	0	8	8
78	R:R:I223	R:R:K220	43.1681	2.91	No	Yes	4	4	4
79	R:R:I223	R:R:Q227	40.4162	4.12	No	No	0	4	4
80	R:R:P228	R:R:Q227	37.5739	1.58	No	No	0	6	4
81	R:R:P228	R:R:R238	31.8465	4.32	No	No	0	6	7
82	R:R:L225	R:R:R238	26.0978	6.07	No	No	0	8	7
83	R:R:L225	R:R:L242	20.2959	2.77	No	Yes	0	8	6
84	R:R:F246	R:R:L242	11.8327	4.87	No	Yes	7	4	6
85	R:R:C248	R:R:Y305	13.5732	5.38	No	Yes	0	8	9
86	R:R:C248	R:R:L304	12.0669	4.76	No	No	0	8	7
87	R:R:P302	R:R:Y306	11.9551	2.78	No	Yes	0	9	7
88	R:R:F182	R:R:R90	11.9657	11.76	Yes	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q33	R:R:Y34	4.51	1	Yes	Yes	5	4	2	2
R:R:Q33	R:R:Y37	9.02	1	Yes	Yes	5	6	2	1
R:R:P288	R:R:Q33	4.74	1	Yes	Yes	5	5	2	2
R:R:Y34	R:R:Y94	9.93	1	Yes	Yes	4	5	2	1
R:R:A183	R:R:Y34	2.67	1	No	Yes	5	4	2	2
R:R:Y37	R:R:Y41	3.97	1	Yes	Yes	6	8	1	1
R:R:Y37	R:R:Y94	8.94	1	Yes	Yes	6	5	1	1
R:R:P288	R:R:Y37	8.34	1	Yes	Yes	5	6	2	1
R:R:L291	R:R:Y37	4.69	1	No	Yes	6	6	1	1
L:L:?1	R:R:Y37	3.61	1	Yes	Yes	0	6	0	1
R:R:L87	R:R:Y41	8.21	0	No	Yes	8	8	2	1
R:R:R90	R:R:Y41	5.14	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:Y41	4.51	1	Yes	Yes	0	8	0	1
R:R:R90	R:R:S86	5.27	1	Yes	No	6	6	1	2
R:R:C109	R:R:L89	3.17	1	No	No	5	6	2	2
R:R:F182	R:R:L89	2.44	1	Yes	No	4	6	1	2
R:R:R90	R:R:Y94	3.09	1	Yes	Yes	6	5	1	1
R:R:K113	R:R:R90	11.14	0	No	Yes	6	6	2	1
R:R:F182	R:R:R90	11.76	1	Yes	Yes	4	6	1	1
L:L:?1	R:R:R90	14.96	1	Yes	Yes	0	6	0	1
R:R:A183	R:R:Y94	4	1	No	Yes	5	5	2	1
L:L:?1	R:R:Y94	5.41	1	Yes	Yes	0	5	0	1
R:R:C106	R:R:C181	7.28	1	No	Yes	9	9	2	2
R:R:C106	R:R:F182	5.59	1	No	Yes	9	4	2	1
R:R:C109	R:R:F182	4.19	1	No	Yes	5	4	2	1
R:R:F110	R:R:R171	4.28	1	No	Yes	5	4	1	1
R:R:F110	R:R:F182	3.22	1	No	Yes	5	4	1	1
L:L:?1	R:R:F110	4.69	1	Yes	No	0	5	0	1
R:R:F167	R:R:Y114	3.09	1	No	No	4	5	1	1
L:L:?1	R:R:Y114	12.63	1	Yes	No	0	5	0	1
R:R:H260	R:R:Y118	6.53	0	No	No	8	7	2	1
L:L:?1	R:R:Y118	5.41	1	Yes	No	0	7	0	1
R:R:C122	R:R:I156	3.27	0	No	No	6	7	1	2
L:L:?1	R:R:C122	2.44	1	Yes	No	0	6	0	1
L:L:?1	R:R:V160	5.73	1	Yes	No	0	8	0	1
R:R:M198	R:R:P166	3.35	1	No	No	5	8	1	1
L:L:?1	R:R:P166	2.53	1	Yes	No	0	8	0	1
L:L:?1	R:R:F167	14.06	1	Yes	No	0	4	0	1
R:R:L185	R:R:R171	4.86	1	No	Yes	5	4	2	1
R:R:R171	R:R:Y187	25.72	1	Yes	No	4	5	1	2
L:L:?1	R:R:R171	6.54	1	Yes	Yes	0	4	0	1
R:R:C181	R:R:F182	8.38	1	Yes	Yes	9	4	2	1
L:L:?1	R:R:F182	2.81	1	Yes	Yes	0	4	0	1
R:R:K270	R:R:Y187	13.14	0	No	No	3	5	2	2
L:L:?1	R:R:M198	4.35	1	Yes	No	0	5	0	1
L:L:?1	R:R:A202	4.85	1	Yes	No	0	6	0	1
R:R:H287	R:R:N262	3.83	1	Yes	Yes	5	5	1	2
R:R:K270	R:R:Y266	9.55	0	No	No	3	5	2	1
R:R:H287	R:R:Y266	30.49	1	Yes	No	5	5	1	1
L:L:?1	R:R:Y266	7.22	1	Yes	No	0	5	0	1
R:R:H287	R:R:P288	3.05	1	Yes	Yes	5	5	1	2
R:R:H287	R:R:L291	7.71	1	Yes	No	5	6	1	1
L:L:?1	R:R:H287	8.9	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L291	9.59	1	Yes	No	0	6	0	1
R:R:I91	R:R:Y41	2.42	0	No	Yes	7	8	2	1
R:R:I121	R:R:Y118	2.42	0	No	No	8	7	2	1
R:R:C164	R:R:V160	1.71	0	No	No	7	8	2	1
R:R:L165	R:R:P166	1.64	0	No	No	4	8	2	1
R:R:A38	R:R:Y94	1.33	0	No	Yes	5	5	2	1
L:L:?1	R:R:A163	1.21	1	Yes	No	0	5	0	1
L:L:?1	R:R:A205	1.21	1	Yes	No	0	4	0	1
L:L:?1	R:R:V159	1.15	1	Yes	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8KGG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	257
Number of Links	293
Number of Hubs	35
Number of Links mediated by Hubs	147
Number of Communities	7
Number of Nodes involved in Communities	54
Number of Links involved in Communities	79

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	48987
Length Of Smallest Path	3
Average Path Length	13.2578
Length of Longest Path	35
Minimum Path Strength	1.21
Average Path Strength	5.29108
Maximum Path Strength	20.02
Minimum Path Correlation	0.7
Average Path Correlation	0.924868
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	48.5206
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.8451
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WJS
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WJS
Name	(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid
Synonyms
Identifier
Formula	C24 H20 N O9 P
Molecular Weight	497.391
SMILES
PubChem
Formal Charge	0
Total Atoms	55
Total Chiral Atoms	2
Total Bonds	54
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O00398
Sequence	>8KGG_nogp_Chain_R C N V T N V K F Q Y S L Y A T T Y I L I F I P G L L A N S A A L W V L C R F I S K K N K A I I F M I N L S V A D L A H V L S L P L R I Y Y Y I S H H W P F Q R A L C L L C F Y L K Y L N M Y A S I C F L T C I S L Q R C F F L L K P F R A R D W K R R Y D V G I S A A I W I V V G T A C L P F P I L R S T D L N N N K S C F A D L G Y K Q M N A V A L V G M I T V A E L A G F V I P V I I I A W C T W K T T I S L R Q P P M A F Q G I S E R Q K A L R M V F M C A A V F F I C F T P Y H I N F I F Y T M V K E T I I S S C P V V R I A L Y F H P F C L C L A S L C C L L D P I L Y Y F M A S E F R D Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8KGG	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-	chim(NtGi2-G13)/β1/γ2	3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	8KGG (No Gprot)	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-		3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005

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Download 8KGG_nogp.zip

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