psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L44	12.9	Yes	No	2	0	2
2	L:L:?1	R:R:Q50	17.83	Yes	Yes	2	0	4
3	L:L:?1	R:R:Y110	9.56	Yes	Yes	2	0	5
4	L:L:?1	R:R:Y111	5.46	Yes	Yes	2	0	5
5	L:L:?1	R:R:R128	4.95	Yes	Yes	2	0	5
6	L:L:?1	R:R:R195	6.37	Yes	Yes	2	0	1
7	L:L:?1	R:R:T201	4.29	Yes	No	2	0	3
8	L:L:?1	R:R:Y203	4.78	Yes	Yes	2	0	4
9	L:L:?1	R:R:N283	8.8	Yes	No	0	0	4
10	L:L:?1	R:R:R287	14.15	Yes	Yes	0	0	5
11	L:L:?1	R:R:N299	8.8	Yes	No	0	0	2
12	L:L:?1	R:R:Y303	11.61	Yes	Yes	2	0	4
13	L:L:?1	R:R:R310	14.86	Yes	Yes	2	0	5
14	R:R:F40	R:R:K41	6.2	No	No	0	5	1
15	R:R:C296	R:R:C42	5.46	No	No	5	4	8
16	R:R:C42	R:R:N299	7.87	No	No	0	8	2
17	R:R:L44	R:R:Y303	9.38	No	Yes	2	2	4
18	R:R:K46	R:R:T45	9.01	No	No	0	4	3
19	R:R:F49	R:R:K46	3.72	No	No	0	4	4
20	R:R:F51	R:R:T47	14.27	Yes	No	0	3	2
21	R:R:T47	R:R:Y303	6.24	No	Yes	0	2	4
22	R:R:A304	R:R:F49	4.16	No	No	0	3	4
23	R:R:Q50	R:R:Y111	6.76	Yes	Yes	2	4	5
24	R:R:Q50	R:R:T115	7.09	Yes	No	0	4	4
25	R:R:Q50	R:R:Y303	11.27	Yes	Yes	2	4	4
26	R:R:Q307	R:R:Q50	11.52	Yes	Yes	2	5	4
27	R:R:Q50	R:R:R310	4.67	Yes	Yes	2	4	5
28	R:R:F51	R:R:K114	11.17	Yes	No	0	3	3
29	R:R:F51	R:R:T115	5.19	Yes	No	0	3	4
30	R:R:V57	R:R:Y53	8.83	No	Yes	0	4	5
31	R:R:V308	R:R:Y53	6.31	No	Yes	0	5	5
32	R:R:L54	R:R:Y58	9.38	Yes	Yes	2	6	7
33	R:R:L54	R:R:Y111	7.03	Yes	Yes	2	6	5
34	R:R:L54	R:R:Q307	6.65	Yes	Yes	2	6	5
35	R:R:L54	R:R:R310	4.86	Yes	Yes	2	6	5
36	R:R:L104	R:R:Y58	4.69	No	Yes	0	7	7
37	R:R:Y111	R:R:Y58	6.95	Yes	Yes	2	5	7
38	R:R:S314	R:R:Y58	5.09	Yes	Yes	0	7	7
39	R:R:I108	R:R:I59	5.89	No	No	0	7	5
40	R:R:S314	R:R:V61	6.46	Yes	No	0	7	6
41	R:R:C318	R:R:V61	5.12	No	No	0	7	6
42	R:R:F62	R:R:V101	5.24	No	No	0	6	5
43	R:R:F62	R:R:P105	8.67	No	No	0	6	9
44	R:R:C318	R:R:I64	6.55	No	No	0	7	5
45	R:R:F66	R:R:F98	8.57	No	Yes	0	5	7
46	R:R:D97	R:R:N69	6.73	Yes	No	0	9	9
47	R:R:F98	R:R:N69	4.83	Yes	No	0	7	9
48	R:R:N69	R:R:P321	8.15	No	No	0	9	9
49	R:R:A72	R:R:F325	5.55	No	Yes	0	8	6
50	R:R:F98	R:R:I73	3.77	Yes	No	0	7	7
51	R:R:M75	R:R:W74	8.14	Yes	No	0	7	3
52	R:R:F78	R:R:W74	8.02	No	No	0	5	3
53	R:R:H79	R:R:M75	10.51	No	Yes	6	5	7
54	R:R:F331	R:R:M75	6.22	No	Yes	0	8	7
55	R:R:M75	R:R:R334	13.65	Yes	No	6	7	5
56	R:R:L335	R:R:M75	5.65	No	Yes	0	5	7
57	R:R:F76	R:R:M80	4.98	Yes	No	0	6	5
58	R:R:F76	R:R:W83	8.02	Yes	Yes	1	6	6
59	R:R:F76	R:R:S87	5.28	Yes	No	1	6	7
60	R:R:F76	R:R:M90	6.22	Yes	No	1	6	8
61	R:R:F76	R:R:F91	4.29	Yes	No	1	6	5
62	R:R:F325	R:R:F76	6.43	Yes	Yes	1	6	6
63	R:R:F78	R:R:V77	13.11	No	No	0	5	3
64	R:R:F91	R:R:V77	3.93	No	No	0	5	3
65	R:R:H79	R:R:R334	16.93	No	No	6	5	5
66	R:R:M80	R:R:R334	19.85	No	No	0	5	5
67	R:R:S87	R:R:W83	12.36	No	Yes	1	7	6
68	R:R:F91	R:R:W83	15.03	No	Yes	1	5	6
69	R:R:H148	R:R:I86	11.93	No	No	0	8	7
70	R:R:A168	R:R:V88	5.09	No	No	0	8	6
71	R:R:I169	R:R:V88	6.14	No	No	0	4	6
72	R:R:C144	R:R:Y89	9.41	No	Yes	0	6	7
73	R:R:H148	R:R:Y89	6.53	No	Yes	0	8	7
74	R:R:A168	R:R:Y89	5.34	No	Yes	0	8	7
75	R:R:I171	R:R:Y89	9.67	No	Yes	0	5	7
76	R:R:F325	R:R:M90	6.22	Yes	No	1	6	8
77	R:R:F141	R:R:N92	14.5	Yes	No	4	7	9
78	R:R:N92	R:R:S172	8.94	No	No	4	9	7
79	R:R:N92	R:R:W176	5.65	No	No	4	9	9
80	R:R:D97	R:R:L93	8.14	Yes	No	0	9	9
81	R:R:L142	R:R:L93	8.3	Yes	No	0	8	9
82	R:R:I145	R:R:L93	4.28	No	No	0	8	9
83	R:R:L95	R:R:L99	5.54	No	No	0	5	7
84	R:R:D97	R:R:S138	4.42	Yes	No	0	9	9
85	R:R:D97	R:R:S317	4.42	Yes	No	0	9	9
86	R:R:D320	R:R:D97	7.98	No	Yes	0	9	9
87	R:R:F98	R:R:L102	8.53	Yes	No	0	7	5
88	R:R:L99	R:R:N134	6.87	No	No	0	7	8
89	R:R:L104	R:R:Y100	9.38	No	Yes	0	7	7
90	R:R:F131	R:R:Y100	18.57	No	Yes	0	7	7
91	R:R:L135	R:R:Y100	7.03	No	Yes	0	7	7
92	R:R:S314	R:R:Y100	3.82	Yes	Yes	0	7	7
93	R:R:S317	R:R:Y100	6.36	No	Yes	0	9	7
94	R:R:Q127	R:R:T103	7.09	No	No	0	4	6
95	R:R:I130	R:R:T103	7.6	Yes	No	0	4	6
96	R:R:A106	R:R:Q127	6.06	No	No	0	6	4
97	R:R:L107	R:R:Y111	4.69	No	Yes	2	7	5
98	R:R:L107	R:R:R128	7.29	No	Yes	2	7	5
99	R:R:F131	R:R:L107	4.87	No	No	0	7	7
100	R:R:Y110	R:R:Y111	15.89	Yes	Yes	2	5	5
101	R:R:T115	R:R:Y110	7.49	No	Yes	0	4	5
102	R:R:W117	R:R:Y110	5.79	Yes	Yes	2	8	5
103	R:R:R128	R:R:Y110	5.14	Yes	Yes	2	5	5
104	R:R:R128	R:R:Y111	4.12	Yes	Yes	2	5	5
105	R:R:R310	R:R:Y111	10.29	Yes	Yes	2	5	5
106	R:R:D116	R:R:N113	8.08	No	No	0	5	4
107	R:R:D116	R:R:I200	4.2	No	No	0	5	4
108	R:R:F119	R:R:W117	16.04	No	Yes	0	7	8
109	R:R:C124	R:R:W117	7.84	No	Yes	2	9	8
110	R:R:C202	R:R:W117	14.37	No	Yes	2	9	8
111	R:R:D121	R:R:K125	13.83	No	No	0	3	7
112	R:R:D121	R:R:T192	7.23	No	No	0	3	5
113	R:R:C124	R:R:C202	7.28	No	No	2	9	9
114	R:R:R128	R:R:S190	5.27	Yes	No	0	5	5
115	R:R:C202	R:R:R128	5.57	No	Yes	2	9	5
116	R:R:D204	R:R:R128	21.44	No	Yes	0	6	5
117	R:R:F129	R:R:I130	3.77	Yes	Yes	0	6	4
118	R:R:F129	R:R:V133	7.87	Yes	No	7	6	5
119	R:R:F129	R:R:I183	5.02	Yes	No	7	6	7
120	R:R:F129	R:R:L187	18.27	Yes	No	0	6	5
121	R:R:I130	R:R:N134	4.25	Yes	No	0	4	8
122	R:R:D204	R:R:H132	11.35	No	No	0	6	5
123	R:R:H132	R:R:K280	5.24	No	No	0	5	6
124	R:R:I183	R:R:V133	4.61	No	No	7	7	5
125	R:R:L135	R:R:Y136	4.69	No	Yes	0	7	7
126	R:R:L135	R:R:Y273	5.86	No	Yes	0	7	8
127	R:R:I183	R:R:Y136	4.84	No	Yes	0	7	7
128	R:R:T221	R:R:Y136	7.49	No	Yes	0	5	7
129	R:R:M225	R:R:Y136	7.18	Yes	Yes	0	5	7
130	R:R:H277	R:R:Y136	8.71	Yes	Yes	0	8	7
131	R:R:G137	R:R:V179	5.52	No	No	0	6	7
132	R:R:F269	R:R:I139	6.28	Yes	No	1	9	7
133	R:R:I139	R:R:Y273	15.71	No	Yes	1	7	8
134	R:R:L140	R:R:V175	4.47	No	No	0	5	7
135	R:R:F141	R:R:S172	5.28	Yes	No	4	7	7
136	R:R:F141	R:R:V175	10.49	Yes	No	0	7	7
137	R:R:F141	R:R:W176	14.03	Yes	No	4	7	9
138	R:R:F269	R:R:L142	3.65	Yes	Yes	0	9	8
139	R:R:D320	R:R:L142	8.14	No	Yes	0	9	8
140	R:R:L142	R:R:Y324	8.21	Yes	Yes	0	8	9
141	R:R:P229	R:R:T143	6.99	Yes	No	0	9	8
142	R:R:L232	R:R:T143	4.42	No	No	0	6	8
143	R:R:I145	R:R:R149	7.52	No	No	1	8	9
144	R:R:I145	R:R:Y324	6.04	No	Yes	1	8	9
145	R:R:I233	R:R:S146	7.74	No	No	1	8	9
146	R:R:C236	R:R:S146	5.16	No	No	0	6	9
147	R:R:S146	R:R:Y237	3.82	No	Yes	1	9	9
148	R:R:H148	R:R:L163	7.71	No	No	0	8	8
149	R:R:R149	R:R:Y237	8.23	No	Yes	1	9	9
150	R:R:R149	R:R:Y324	7.2	No	Yes	1	9	9
151	R:R:V154	R:R:Y150	12.62	No	Yes	8	7	7
152	R:R:Y150	R:R:Y155	4.96	Yes	Yes	8	7	6
153	R:R:C236	R:R:Y150	5.38	No	Yes	0	6	7
154	R:R:L239	R:R:Y150	8.21	No	Yes	0	4	7
155	R:R:I240	R:R:V153	9.22	No	No	0	7	8
156	R:R:V154	R:R:Y155	11.36	No	Yes	8	7	6
157	R:R:K164	R:R:N167	13.99	No	No	0	6	4
158	R:R:I178	R:R:L174	5.71	No	No	0	5	3
159	R:R:A182	R:R:M225	4.83	No	Yes	0	4	5
160	R:R:P185	R:R:Y217	19.47	No	Yes	0	8	5
161	R:R:I186	R:R:S190	6.19	No	No	0	4	5
162	R:R:I186	R:R:Y217	8.46	No	Yes	0	4	5
163	R:R:F188	R:R:Y189	10.32	No	Yes	0	4	4
164	R:R:F188	R:R:Y210	6.19	No	No	0	4	4
165	R:R:T206	R:R:Y189	8.74	No	Yes	3	5	4
166	R:R:S213	R:R:Y189	6.36	No	Yes	0	1	4
167	R:R:Y189	R:R:Y214	17.87	Yes	Yes	3	4	4
168	R:R:Y189	R:R:Y217	3.97	Yes	Yes	3	4	5
169	R:R:I200	R:R:V194	4.61	No	No	0	4	2
170	R:R:R195	R:R:T201	3.88	Yes	No	2	1	3
171	R:R:R195	R:R:Y203	5.14	Yes	Yes	2	1	4
172	R:R:N197	R:R:T199	5.85	No	No	0	4	4
173	R:R:T201	R:R:Y203	9.99	No	Yes	2	3	4
174	R:R:S207	R:R:Y203	3.82	No	Yes	0	5	4
175	R:R:T205	R:R:Y214	9.99	No	Yes	3	5	4
176	R:R:L284	R:R:T205	4.42	No	No	3	4	5
177	R:R:R287	R:R:T205	5.17	Yes	No	0	5	5
178	R:R:T206	R:R:Y210	3.75	No	No	0	5	4
179	R:R:T206	R:R:Y214	7.49	No	Yes	3	5	4
180	R:R:E209	R:R:S207	8.62	No	No	0	3	5
181	R:R:E209	R:R:Y210	15.71	No	No	0	3	4
182	R:R:L211	R:R:R287	6.07	No	Yes	0	4	5
183	R:R:L211	R:R:L288	9.69	No	No	0	4	3
184	R:R:L288	R:R:R212	10.93	No	No	0	3	1
185	R:R:Y214	R:R:Y217	6.95	Yes	Yes	3	4	5
186	R:R:S218	R:R:Y214	3.82	No	Yes	0	5	4
187	R:R:L284	R:R:Y214	7.03	No	Yes	3	4	4
188	R:R:F215	R:R:M219	3.73	Yes	No	0	4	4
189	R:R:F215	R:R:L284	3.65	Yes	No	0	4	4
190	R:R:F215	R:R:L288	3.65	Yes	No	0	4	3
191	R:R:T221	R:R:Y217	8.74	No	Yes	0	5	5
192	R:R:K280	R:R:S218	4.59	No	No	0	6	5
193	R:R:M219	R:R:T281	4.52	No	No	0	4	5
194	R:R:H277	R:R:T222	8.21	Yes	No	0	8	5
195	R:R:F226	R:R:L230	9.74	Yes	Yes	1	8	6
196	R:R:F226	R:R:F269	4.29	Yes	Yes	1	8	9
197	R:R:F226	R:R:Y273	4.13	Yes	Yes	1	8	8
198	R:R:F226	R:R:I274	5.02	Yes	Yes	1	8	5
199	R:R:F226	R:R:H277	30.55	Yes	Yes	0	8	8
200	R:R:F269	R:R:L230	3.65	Yes	Yes	1	9	6
201	R:R:I274	R:R:L230	8.56	Yes	Yes	1	5	6
202	R:R:I233	R:R:Y237	4.84	No	Yes	1	8	9
203	R:R:F269	R:R:I233	8.79	Yes	No	1	9	8
204	R:R:V262	R:R:Y237	5.05	No	Yes	0	7	9
205	R:R:V265	R:R:Y237	7.57	No	Yes	0	7	9
206	R:R:P266	R:R:Y237	11.13	No	Yes	0	7	9
207	R:R:L239	R:R:R242	3.64	No	No	0	4	5
208	R:R:I240	R:R:V262	6.14	No	No	0	7	7
209	R:R:R242	R:R:Y246	9.26	No	No	0	5	5
210	R:R:L244	R:R:L249	5.54	No	No	0	8	3
211	R:R:I259	R:R:L244	4.28	No	No	0	6	8
212	R:R:D248	R:R:L254	4.07	No	No	0	3	4
213	R:R:L249	R:R:L254	5.54	No	No	0	3	4
214	R:R:D250	R:R:N251	12.12	No	No	0	3	4
215	R:R:P253	R:R:S252	5.34	No	No	0	4	3
216	R:R:R255	R:R:R256	5.33	No	No	0	6	5
217	R:R:R256	R:R:Y260	7.2	No	No	0	5	6
218	R:R:K257	R:R:L261	4.23	No	No	0	8	7
219	R:R:D329	R:R:K257	11.06	No	No	0	5	8
220	R:R:V265	R:R:Y324	8.83	No	Yes	0	7	9
221	R:R:V268	R:R:V319	6.41	No	No	0	6	5
222	R:R:L323	R:R:V268	4.47	No	No	0	7	6
223	R:R:F269	R:R:Y273	7.22	Yes	Yes	1	9	8
224	R:R:S272	R:R:Y273	3.82	No	Yes	1	8	8
225	R:R:N316	R:R:S272	8.94	No	No	1	9	8
226	R:R:N316	R:R:Y273	25.59	No	Yes	1	9	8
227	R:R:F276	R:R:H277	13.58	No	Yes	0	7	8
228	R:R:A313	R:R:F276	6.93	No	No	0	7	7
229	R:R:M279	R:R:M282	7.22	Yes	No	0	5	5
230	R:R:M279	R:R:T305	9.03	Yes	No	0	5	4
231	R:R:M279	R:R:T309	9.03	Yes	No	0	5	7
232	R:R:K280	R:R:Y306	7.17	No	Yes	0	6	4
233	R:R:M282	R:R:V302	6.09	No	No	0	5	4
234	R:R:N283	R:R:Y306	17.44	No	Yes	0	4	4
235	R:R:D289	R:R:F290	7.17	No	No	0	1	3
236	R:R:F290	R:R:M295	12.44	No	No	0	3	4
237	R:R:P293	R:R:T292	5.25	No	No	0	1	2
238	R:R:R301	R:R:T305	6.47	No	No	0	2	4
239	R:R:Q307	R:R:Y303	11.27	Yes	Yes	2	5	4
240	R:R:Q307	R:R:Y306	5.64	Yes	Yes	2	5	4
241	R:R:R310	R:R:Y306	23.66	Yes	Yes	2	5	4
242	R:R:Q307	R:R:R310	11.68	Yes	Yes	2	5	5
243	R:R:G311	R:R:S314	3.71	No	Yes	0	4	7
244	R:R:F325	R:R:Y324	4.13	Yes	Yes	1	6	9
245	R:R:F325	R:R:F331	7.5	Yes	No	0	6	8
246	R:R:I108	R:R:Y58	3.63	No	Yes	0	7	7
247	R:R:I245	R:R:Y246	3.63	No	No	0	3	5
248	R:R:N197	R:R:R195	3.62	No	Yes	0	4	1
249	R:R:D208	R:R:R287	3.57	No	Yes	0	3	5
250	R:R:G65	R:R:I64	3.53	No	No	0	8	5
251	R:R:P229	R:R:V228	3.53	Yes	No	0	9	6
252	R:R:L54	R:R:Y53	3.52	Yes	Yes	0	6	5
253	R:R:P275	R:R:T309	3.5	No	No	0	9	7
254	R:R:K165	R:R:W83	3.48	No	Yes	0	3	6
255	R:R:I139	R:R:P229	3.39	No	Yes	0	7	9
256	R:R:I274	R:R:P275	3.39	Yes	No	0	5	9
257	R:R:C124	R:R:T192	3.38	No	No	0	9	5
258	R:R:K81	R:R:P82	3.35	No	No	0	6	5
259	R:R:D121	R:R:G191	3.35	No	No	0	3	4
260	R:R:L140	R:R:P229	3.28	No	Yes	0	5	9
261	R:R:S151	R:R:S159	3.26	No	No	0	5	5
262	R:R:A270	R:R:I274	3.25	No	Yes	0	5	5
263	R:R:S172	R:R:V88	3.23	No	No	0	7	6
264	R:R:S317	R:R:V101	3.23	No	No	0	9	5
265	R:R:V133	R:R:V179	3.21	No	No	0	5	7
266	R:R:V241	R:R:V262	3.21	No	No	0	5	7
267	R:R:A243	R:R:K247	3.21	No	No	0	5	4
268	R:R:A327	R:R:L261	3.15	No	No	0	6	7
269	R:R:C42	R:R:D300	3.11	No	No	5	8	2
270	R:R:C296	R:R:D300	3.11	No	No	5	4	2
271	L:L:?1	R:R:Q291	3.1	Yes	No	0	0	2
272	R:R:I259	R:R:S258	3.1	No	No	0	6	7
273	R:R:F49	R:R:Y53	3.09	No	Yes	0	4	5
274	R:R:F51	R:R:Y52	3.09	Yes	No	0	3	3
275	R:R:K198	R:R:V194	3.04	No	No	0	2	2
276	R:R:M279	R:R:V278	3.04	Yes	No	0	5	6
277	R:R:F51	R:R:G48	3.01	Yes	No	0	3	4
278	R:R:L67	R:R:S70	3	No	No	0	4	3
279	R:R:L67	R:R:V71	2.98	No	No	0	4	5
280	R:R:L244	R:R:V153	2.98	No	No	0	8	8
281	R:R:L177	R:R:V173	2.98	No	No	0	4	4
282	R:R:L323	R:R:V265	2.98	No	No	0	7	7
283	R:R:I259	R:R:I263	2.94	No	No	0	6	4
284	R:R:G193	R:R:Y203	2.9	No	Yes	0	2	4
285	R:R:I130	R:R:L126	2.85	Yes	No	0	4	4
286	R:R:I264	R:R:L261	2.85	No	No	0	4	7
287	R:R:I264	R:R:L323	2.85	No	No	0	4	7
288	R:R:I322	R:R:L326	2.85	No	No	0	6	6
289	R:R:G120	R:R:W117	2.81	No	Yes	0	6	8
290	R:R:K196	R:R:N197	2.8	No	No	0	2	4
291	R:R:P55	R:R:Y111	2.78	No	Yes	0	6	5
292	R:R:D208	R:R:K41	2.77	No	No	0	3	1
293	R:R:A94	R:R:F325	2.77	No	Yes	0	9	6
294	R:R:L230	R:R:L234	2.77	Yes	No	0	6	4
295	R:R:A286	R:R:F290	2.77	No	No	0	1	3
296	R:R:A96	R:R:W176	2.59	No	No	0	8	9
297	R:R:F119	R:R:M123	2.49	No	No	0	7	5
298	R:R:K257	R:R:R255	2.48	No	No	0	8	6
299	R:R:D329	R:R:R332	2.38	No	No	0	5	8
300	R:R:F215	R:R:R285	2.14	Yes	No	0	4	4
301	R:R:G68	R:R:P321	2.03	No	No	0	6	9
302	R:R:A168	R:R:G85	1.95	No	No	0	8	6
303	R:R:G85	R:R:S84	1.86	No	No	0	6	7
304	R:R:G152	R:R:S151	1.86	No	No	0	7	5
305	R:R:G193	R:R:V194	1.84	No	No	0	2	2
306	R:R:G238	R:R:V241	1.84	No	No	0	3	5
307	R:R:P185	R:R:S184	1.78	No	No	0	8	4
308	R:R:G68	R:R:L67	1.71	No	No	0	6	4
309	R:R:G235	R:R:L234	1.71	No	No	0	3	4
310	R:R:A243	R:R:V154	1.7	No	No	0	5	7
311	R:R:A286	R:R:V302	1.7	No	No	0	1	4
312	R:R:A294	R:R:T292	1.68	No	No	0	3	2
313	R:R:C220	R:R:I216	1.64	No	No	0	3	3
314	R:R:L312	R:R:P275	1.64	No	No	0	7	9
315	R:R:S184	R:R:V180	1.62	No	No	0	4	4
316	R:R:A224	R:R:M225	1.61	No	Yes	0	4	5
317	R:R:A294	R:R:M295	1.61	No	No	0	3	4
318	R:R:M219	R:R:V223	1.52	No	No	0	4	5
319	R:R:I264	R:R:T267	1.52	No	No	0	4	4
320	R:R:L315	R:R:V57	1.49	No	No	0	5	4
321	R:R:L315	R:R:V61	1.49	No	No	0	5	6
322	R:R:I59	R:R:I63	1.47	No	No	0	5	5
323	R:R:I178	R:R:M225	1.46	No	Yes	0	5	5
324	R:R:F112	R:R:P55	1.44	No	No	0	4	6
325	R:R:I118	R:R:N113	1.42	No	No	0	3	4
326	R:R:P156	R:R:Y155	1.39	No	Yes	0	8	6
327	R:R:R162	R:R:S159	1.32	No	No	0	4	5
328	R:R:S151	R:R:Y150	1.27	No	Yes	0	5	7
329	R:R:F298	R:R:M295	1.24	No	No	0	1	4
330	R:R:F331	R:R:L326	1.22	No	No	0	8	6
331	R:R:K158	R:R:Y155	1.19	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.10429	14	2	0
2	R:R:Q50	9.85667	6	2	4
3	R:R:F51	7.346	5	0	3
4	R:R:Y53	5.4375	4	0	5
5	R:R:L54	6.288	5	2	6
6	R:R:Y58	5.948	5	2	7
7	R:R:M75	8.834	5	6	7
8	R:R:F76	5.87	6	1	6
9	R:R:W83	9.7225	4	1	6
10	R:R:Y89	7.7375	4	0	7
11	R:R:D97	6.338	5	0	9
12	R:R:F98	6.425	4	0	7
13	R:R:Y100	9.032	5	0	7
14	R:R:Y110	8.774	5	2	5
15	R:R:Y111	7.10778	9	2	5
16	R:R:W117	9.37	5	2	8
17	R:R:R128	7.68286	7	2	5
18	R:R:F129	8.7325	4	7	6
19	R:R:I130	4.6175	4	0	4
20	R:R:Y136	6.582	5	0	7
21	R:R:F141	11.075	4	4	7
22	R:R:L142	7.075	4	0	8
23	R:R:Y150	6.488	5	8	7
24	R:R:Y155	4.725	4	8	6
25	R:R:Y189	9.452	5	3	4
26	R:R:R195	4.7525	4	2	1
27	R:R:Y203	5.326	5	2	4
28	R:R:Y214	8.85833	6	3	4
29	R:R:F215	3.2925	4	0	4
30	R:R:Y217	9.518	5	3	5
31	R:R:M225	3.77	4	0	5
32	R:R:F226	10.746	5	1	8
33	R:R:P229	4.2975	4	0	9
34	R:R:L230	6.18	4	1	6
35	R:R:Y237	6.77333	6	1	9
36	R:R:F269	5.64667	6	1	9
37	R:R:Y273	10.3883	6	1	8
38	R:R:I274	5.055	4	1	5
39	R:R:H277	15.2625	4	0	8
40	R:R:M279	7.08	4	0	5
41	R:R:R287	7.24	4	0	5
42	R:R:Y303	9.954	5	2	4
43	R:R:Y306	13.4775	4	2	4
44	R:R:Q307	9.352	5	2	5
45	R:R:R310	11.67	6	2	5
46	R:R:S314	4.77	4	0	7
47	R:R:Y324	6.882	5	1	9
48	R:R:F325	5.43333	6	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R287	19.2006	14.15	Yes	Yes	0	0	5
2	L:L:?1	R:R:N299	13.1994	8.8	Yes	No	0	0	2
3	R:R:C42	R:R:N299	10.1482	7.87	No	No	0	8	2
4	L:L:?1	R:R:Y111	62.1823	5.46	Yes	Yes	2	0	5
5	R:R:L54	R:R:Y53	12.4754	3.52	Yes	Yes	0	6	5
6	R:R:Q50	R:R:T115	12.1946	7.09	Yes	No	0	4	4
7	R:R:F51	R:R:T115	22.6704	5.19	Yes	No	0	3	4
8	R:R:T115	R:R:Y110	16.1914	7.49	No	Yes	0	4	5
9	R:R:Y111	R:R:Y58	75.2512	6.95	Yes	Yes	2	5	7
10	R:R:L104	R:R:Y58	48.8032	4.69	No	Yes	0	7	7
11	R:R:S314	R:R:Y58	50.3374	5.09	Yes	Yes	0	7	7
12	R:R:L104	R:R:Y100	49.2908	9.38	No	Yes	0	7	7
13	R:R:S317	R:R:Y100	84.8651	6.36	No	Yes	0	9	7
14	R:R:S314	R:R:Y100	54.6222	3.82	Yes	Yes	0	7	7
15	R:R:L107	R:R:Y111	36.8671	4.69	No	Yes	2	7	5
16	R:R:F131	R:R:L107	74.5912	4.87	No	No	0	7	7
17	R:R:F131	R:R:Y100	75.0025	18.57	No	Yes	0	7	7
18	L:L:?1	R:R:R128	22.8379	4.95	Yes	Yes	2	0	5
19	R:R:L107	R:R:R128	37.4655	7.29	No	Yes	2	7	5
20	R:R:D97	R:R:S317	82.9443	4.42	Yes	No	0	9	9
21	R:R:D97	R:R:N69	16.4229	6.73	Yes	No	0	9	9
22	R:R:L135	R:R:Y100	100	7.03	No	Yes	0	7	7
23	R:R:L135	R:R:Y273	99.6577	5.86	No	Yes	0	7	8
24	R:R:F269	R:R:Y273	66.876	7.22	Yes	Yes	1	9	8
25	R:R:F269	R:R:L142	48.0743	3.65	Yes	Yes	0	9	8
26	R:R:L142	R:R:Y324	87.7315	8.21	Yes	Yes	0	8	9
27	R:R:F325	R:R:Y324	69.8138	4.13	Yes	Yes	1	6	9
28	R:R:D97	R:R:L93	54.6124	8.14	Yes	No	0	9	9
29	R:R:L142	R:R:L93	28.2826	8.3	Yes	No	0	8	9
30	R:R:D320	R:R:D97	28.1915	7.98	No	Yes	0	9	9
31	R:R:D320	R:R:L142	27.9945	8.14	No	Yes	0	9	8
32	R:R:I145	R:R:L93	26.9922	4.28	No	No	0	8	9
33	R:R:I145	R:R:Y324	24.3326	6.04	No	Yes	1	8	9
34	R:R:F325	R:R:F331	29.2332	7.5	Yes	No	0	6	8
35	R:R:F331	R:R:M75	19.3213	6.22	No	Yes	0	8	7
36	R:R:F325	R:R:F76	27.7408	6.43	Yes	Yes	1	6	6
37	R:R:I139	R:R:Y273	19.2277	15.71	No	Yes	1	7	8
38	R:R:I139	R:R:P229	27.135	3.39	No	Yes	0	7	9
39	R:R:L140	R:R:P229	22.3478	3.28	No	Yes	0	5	9
40	R:R:L140	R:R:V175	21.1387	4.47	No	No	0	5	7
41	R:R:F141	R:R:V175	19.9246	10.49	Yes	No	0	7	7
42	R:R:F141	R:R:S172	14.9897	5.28	Yes	No	4	7	7
43	R:R:S172	R:R:V88	13.8347	3.23	No	No	0	7	6
44	R:R:A168	R:R:V88	11.3327	5.09	No	No	0	8	6
45	R:R:L135	R:R:Y136	31.2648	4.69	No	Yes	0	7	7
46	R:R:I183	R:R:Y136	20.4073	4.84	No	Yes	0	7	7
47	R:R:F129	R:R:I183	14.6006	5.02	Yes	No	7	6	7
48	R:R:F129	R:R:I130	11.7785	3.77	Yes	Yes	0	6	4
49	R:R:T221	R:R:Y217	27.1252	8.74	No	Yes	0	5	5
50	R:R:T221	R:R:Y136	27.5734	7.49	No	Yes	0	5	7
51	R:R:Y214	R:R:Y217	15.3492	6.95	Yes	Yes	3	4	5
52	R:R:W117	R:R:Y110	14.2681	5.79	Yes	Yes	2	8	5
53	L:L:?1	R:R:Y203	30.063	4.78	Yes	Yes	2	0	4
54	R:R:G193	R:R:Y203	23.6653	2.9	No	Yes	0	2	4
55	R:R:G193	R:R:V194	20.299	1.84	No	No	0	2	2
56	R:R:I200	R:R:V194	13.5515	4.61	No	No	0	4	2
57	R:R:D116	R:R:I200	10.1704	4.2	No	No	0	5	4
58	R:R:H277	R:R:Y136	18.9815	8.71	Yes	Yes	0	8	7
59	R:R:F269	R:R:I233	51.1894	8.79	Yes	No	1	9	8
60	R:R:I233	R:R:S146	19.9	7.74	No	No	1	8	9
61	R:R:C236	R:R:S146	22.3724	5.16	No	No	0	6	9
62	R:R:I233	R:R:Y237	30.2822	4.84	No	Yes	1	8	9
63	R:R:C236	R:R:Y150	20.9983	5.38	No	Yes	0	6	7
64	R:R:V262	R:R:Y237	15.5634	5.05	No	Yes	0	7	9
65	R:R:I240	R:R:V262	11.7686	6.14	No	No	0	7	7
66	L:L:?1	R:R:R195	12.9605	6.37	Yes	Yes	2	0	1
67	R:R:N197	R:R:R195	10.1482	3.62	No	Yes	0	4	1
68	R:R:F226	R:R:Y273	15.0931	4.13	Yes	Yes	1	8	8
69	R:R:F226	R:R:I274	21.8947	5.02	Yes	Yes	1	8	5
70	R:R:V265	R:R:Y324	44.9887	8.83	No	Yes	0	7	9
71	R:R:V265	R:R:Y237	17.7748	7.57	No	Yes	0	7	9
72	R:R:I240	R:R:V153	10.4438	9.22	No	No	0	7	8
73	R:R:L323	R:R:V265	55.3068	2.98	No	No	0	7	7
74	R:R:I264	R:R:L323	42.563	2.85	No	No	0	4	7
75	R:R:I264	R:R:L261	33.9539	2.85	No	No	0	4	7
76	R:R:K257	R:R:L261	25.3201	4.23	No	No	0	8	7
77	R:R:K257	R:R:R255	13.0295	2.48	No	No	0	8	6
78	R:R:I274	R:R:P275	25.5762	3.39	Yes	No	0	5	9
79	R:R:P275	R:R:T309	22.6409	3.5	No	No	0	9	7
80	R:R:M279	R:R:T309	21.1658	9.03	Yes	No	0	5	7
81	R:R:M279	R:R:M282	15.2162	7.22	Yes	No	0	5	5
82	R:R:M282	R:R:V302	13.7165	6.09	No	No	0	5	4
83	R:R:A286	R:R:V302	12.2119	1.7	No	No	0	1	4
84	R:R:A286	R:R:F290	10.7023	2.77	No	No	0	1	3
85	R:R:Q50	R:R:Y111	17.8339	6.76	Yes	Yes	2	4	5
86	R:R:Y110	R:R:Y111	22.9733	15.89	Yes	Yes	2	5	5
87	R:R:F226	R:R:F269	20.1931	4.29	Yes	Yes	1	8	9
88	R:R:F226	R:R:H277	17.2774	30.55	Yes	Yes	0	8	8
89	R:R:L54	R:R:Y58	19.0332	9.38	Yes	Yes	2	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L44	12.9	2	Yes	No	0	2	0	1
L:L:?1	R:R:Q50	17.83	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y110	9.56	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y111	5.46	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:R128	4.95	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:R195	6.37	2	Yes	Yes	0	1	0	1
L:L:?1	R:R:T201	4.29	2	Yes	No	0	3	0	1
L:L:?1	R:R:Y203	4.78	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:N283	8.8	2	Yes	No	0	4	0	1
L:L:?1	R:R:R287	14.15	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:N299	8.8	2	Yes	No	0	2	0	1
L:L:?1	R:R:Y303	11.61	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:R310	14.86	2	Yes	Yes	0	5	0	1
R:R:C42	R:R:N299	7.87	5	No	No	8	2	2	1
R:R:L44	R:R:Y303	9.38	2	No	Yes	2	4	1	1
R:R:T47	R:R:Y303	6.24	0	No	Yes	2	4	2	1
R:R:Q50	R:R:Y111	6.76	2	Yes	Yes	4	5	1	1
R:R:Q50	R:R:T115	7.09	2	Yes	No	4	4	1	2
R:R:Q50	R:R:Y303	11.27	2	Yes	Yes	4	4	1	1
R:R:Q307	R:R:Q50	11.52	2	Yes	Yes	5	4	2	1
R:R:Q50	R:R:R310	4.67	2	Yes	Yes	4	5	1	1
R:R:L54	R:R:Y58	9.38	2	Yes	Yes	6	7	2	2
R:R:L54	R:R:Y111	7.03	2	Yes	Yes	6	5	2	1
R:R:L54	R:R:Q307	6.65	2	Yes	Yes	6	5	2	2
R:R:L54	R:R:R310	4.86	2	Yes	Yes	6	5	2	1
R:R:Y111	R:R:Y58	6.95	2	Yes	Yes	5	7	1	2
R:R:L107	R:R:Y111	4.69	2	No	Yes	7	5	2	1
R:R:L107	R:R:R128	7.29	2	No	Yes	7	5	2	1
R:R:Y110	R:R:Y111	15.89	2	Yes	Yes	5	5	1	1
R:R:T115	R:R:Y110	7.49	0	No	Yes	4	5	2	1
R:R:W117	R:R:Y110	5.79	2	Yes	Yes	8	5	2	1
R:R:R128	R:R:Y110	5.14	2	Yes	Yes	5	5	1	1
R:R:R128	R:R:Y111	4.12	2	Yes	Yes	5	5	1	1
R:R:R310	R:R:Y111	10.29	2	Yes	Yes	5	5	1	1
R:R:C202	R:R:W117	14.37	2	No	Yes	9	8	2	2
R:R:R128	R:R:S190	5.27	2	Yes	No	5	5	1	2
R:R:C202	R:R:R128	5.57	2	No	Yes	9	5	2	1
R:R:D204	R:R:R128	21.44	0	No	Yes	6	5	2	1
R:R:R195	R:R:T201	3.88	2	Yes	No	1	3	1	1
R:R:R195	R:R:Y203	5.14	2	Yes	Yes	1	4	1	1
R:R:T201	R:R:Y203	9.99	2	No	Yes	3	4	1	1
R:R:S207	R:R:Y203	3.82	0	No	Yes	5	4	2	1
R:R:R287	R:R:T205	5.17	0	Yes	No	5	5	1	2
R:R:L211	R:R:R287	6.07	0	No	Yes	4	5	2	1
R:R:N283	R:R:Y306	17.44	0	No	Yes	4	4	1	2
R:R:Q307	R:R:Y303	11.27	2	Yes	Yes	5	4	2	1
R:R:Q307	R:R:Y306	5.64	2	Yes	Yes	5	4	2	2
R:R:R310	R:R:Y306	23.66	2	Yes	Yes	5	4	1	2
R:R:Q307	R:R:R310	11.68	2	Yes	Yes	5	5	2	1
R:R:N197	R:R:R195	3.62	0	No	Yes	4	1	2	1
R:R:D208	R:R:R287	3.57	0	No	Yes	3	5	2	1
L:L:?1	R:R:Q291	3.1	2	Yes	No	0	2	0	1
R:R:G193	R:R:Y203	2.9	0	No	Yes	2	4	2	1
R:R:P55	R:R:Y111	2.78	0	No	Yes	6	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JCL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.64
Number of Linked Nodes	278
Number of Links	331
Number of Hubs	48
Number of Links mediated by Hubs	192
Number of Communities	8
Number of Nodes involved in Communities	61
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	114914
Length Of Smallest Path	3
Average Path Length	13.3097
Length of Longest Path	27
Minimum Path Strength	1.29
Average Path Strength	6.55628
Maximum Path Strength	22.065
Minimum Path Correlation	0.7
Average Path Correlation	0.919495
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	42.4154
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.031
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • A1 adenosine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • adenosine receptor binding • adenyl ribonucleotide binding • nucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • adenyl nucleotide binding • ATP binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • ADP binding • G protein-coupled purinergic nucleotide receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled ATP receptor activity • protein heterodimerization activity • protein dimerization activity • scaffold protein binding • G protein-coupled ADP receptor activity • molecular function regulator activity • signaling receptor regulator activity • multicellular organismal process • regulation of biological process • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • biological regulation • positive regulation of biological process • mating behavior • behavior • positive regulation of penile erection • positive regulation of multicellular organismal process • reproductive behavior • regulation of multicellular organismal process • penile erection • copulation • positive regulation of reproductive process • positive regulation of cell communication • regulation of localization • regulation of cellular process • regulation of hormone secretion • signaling • transport • positive regulation of secretion by cell • hormone secretion • cell communication • localization • positive regulation of hormone secretion • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • regulation of biological quality • positive regulation of cellular process • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • positive regulation of transport • regulation of cell communication • hormone transport • cellular process • positive regulation of signaling • monoatomic ion transport • protein localization to cell periphery • cellular localization • protein localization to plasma membrane • macromolecule localization • intracellular protein localization • localization within membrane • protein localization to membrane • cellular response to stimulus • purinergic nucleotide receptor signaling pathway • response to stimulus • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • G protein-coupled adenosine receptor signaling pathway • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • signal transduction involved in regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • cellular response to ATP • response to organophosphorus • response to oxygen-containing compound • response to nitrogen compound • response to ATP • response to purine-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of inositol phosphate biosynthetic process • regulation of inositol trisphosphate biosynthetic process • alcohol metabolic process • inositol phosphate metabolic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of inositol trisphosphate biosynthetic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • inositol trisphosphate metabolic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • regulation of alcohol biosynthetic process • positive regulation of phosphorus metabolic process • small molecule biosynthetic process • inositol trisphosphate biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of carbohydrate metabolic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulated exocytosis • modulation of chemical synaptic transmission • synaptic vesicle cycle • synaptic vesicle exocytosis • vesicle-mediated transport • vesicle-mediated transport in synapse • regulation of regulated secretory pathway • synaptic signaling • establishment of localization in cell • trans-synaptic signaling • neurotransmitter secretion • regulation of neurotransmitter transport • regulation of synaptic vesicle exocytosis • neurotransmitter transport • regulation of vesicle-mediated transport • chemical synaptic transmission • signal release from synapse • regulation of trans-synaptic signaling • exocytosis • regulation of neurotransmitter secretion • anterograde trans-synaptic signaling • regulation of exocytosis • regulation of monoatomic ion transport • positive regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • eating behavior • feeding behavior • G protein-coupled purinergic nucleotide receptor signaling pathway • developmental process • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • cellular response to purine-containing compound • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • response to endogenous stimulus • response to growth factor • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular developmental process • glial cell migration • nervous system development • neurogenesis • multicellular organism development • gliogenesis • cell differentiation • cell migration • cell motility • system development • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • blood circulation • regulation of anatomical structure size • monoamine transport • nitrogen compound transport • negative regulation of amine transport • regulation of catecholamine secretion • negative regulation of biological process • negative regulation of transport • organic hydroxy compound transport • negative regulation of secretion • catecholamine transport • negative regulation of cellular process • negative regulation of norepinephrine secretion • negative regulation of secretion by cell • norepinephrine transport • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • muscle system process • relaxation of muscle • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • somatodendritic compartment • dendrite • dendritic tree • glutamatergic synapse • cell body • apical part of cell • apical plasma membrane • cell surface • presynaptic active zone membrane • presynaptic membrane • presynapse • presynaptic active zone • postsynaptic density • neuron to neuron synapse • postsynaptic specialization • asymmetric synapse • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ADP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ADP
Name	Adenosine disphosphate
Synonyms	Adenosine disphosphate ADP
Identifier
Formula	C10 H15 N5 O10 P2
Molecular Weight	427.201
SMILES
PubChem	6022
Formal Charge	0
Total Atoms	42
Total Chiral Atoms	5
Total Bonds	44
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47900
Sequence	>9JCL_nogp_Chain_R F K C A L T K T G F Q F Y Y L P A V Y I L V F I I G F L G N S V A I W M F V F H M K P W S G I S V Y M F N L A L A D F L Y V L T L P A L I F Y Y F N K T D W I F G D A M C K L Q R F I F H V N L Y G S I L F L T C I S A H R Y S G V V Y P L K S L G R L K K K N A I C I S V L V W L I V V V A I S P I L F Y S G T G V R K N K T I T C Y D T T S D E Y L R S Y F I Y S M C T T V A M F C V P L V L I L G C Y G L I V R A L I Y K D L D N S P L R R K S I Y L V I I V P T V F A V S Y I P F H V M K T M N L R A R L D F Q T P A M C A F N D R V Y A T Y Q V T R G L A S L N S C V D P I L Y F L A G D T F R R R L S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4XNV	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	-	BPTU	-	2.2	2015-04-01	doi.org/10.1038/nature14287
	4XNW	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	MRS2500	-	-	2.7	2015-04-01	doi.org/10.1038/nature14287
	7XXH	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-	chim(NtGi1-G11)/β1/γ2	2.9	2023-06-07	doi.org/10.1093/procel/pwac025
	7XXH (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	2MeSADP	-		2.9	2023-06-07	doi.org/10.1093/procel/pwac025
	8KGG	A	Nucleotide	P2Y	P2Y10	Homo sapiens	Lysophosphatidylserine (WJS)	-	chim(NtGi2-G13)/β1/γ2	3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	8KGG (No Gprot)	A	Nucleotide	P2Y	P2Y10	Homo sapiens	Lysophosphatidylserine (WJS)	-		3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	8WJX	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-	chim(Gs-CtGq)/β1/γ2	3.2	2024-10-02	To be published
	8WJX (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-		3.2	2024-10-02	To be published
	9JCL	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-	chim(Gs-CtGq)/β1/γ2	2.76	2025-09-10	To be published
	9JCL (No Gprot)	A	Nucleotide	P2Y	P2Y₁	Homo sapiens	ADP	-		2.76	2025-09-10	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JCL_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.