Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:E33 5.7175406
2A:A:V34 6.63254175
3A:A:L36 4.814177
4A:A:L38 4.9875408
5A:A:K46 4.434209
6A:A:F191 7.3654185
7A:A:F196 9.54177
8A:A:K197 6.99416
9A:A:F199 8.194515
10A:A:V201 5.1025419
11A:A:Q204 5.56419
12A:A:R208 4.9175409
13A:A:K210 6.498519
14A:A:W211 5.416519
15A:A:H213 6.0825438
16A:A:F215 7.35619
17A:A:I222 4.355407
18A:A:F223 6.065449
19A:A:Y230 7.7156118
20A:A:F250 7.618549
21A:A:C254 3.9875445
22A:A:N256 3.725438
23A:A:W258 6.02286735
24A:A:F259 6.104539
25A:A:I265 2.895408
26A:A:L266 4.365449
27A:A:F267 5.754129
28A:A:L268 4.292548
29A:A:F274 6.695409
30A:A:K277 6.7554119
31A:A:L283 5.60254117
32A:A:C286 5.11446
33A:A:Y287 6.815647
34A:A:Y296 4.8275404
35A:A:I303 4.45447
36A:A:F307 5.955448
37A:A:N311 6.4925448
38A:A:E318 10.4654214
39A:A:I319 5.7875445
40A:A:Y320 5.51507
41A:A:H322 7.6354129
42A:A:N331 4.58754128
43A:A:Q333 4.70254185
44A:A:F336 6.87754188
45A:A:K345 9.0825405
46A:A:L348 5.164529
47A:A:K349 5.48405
48B:B:R22 6.9125406
49B:B:D27 5.82254148
50B:B:L30 3.975405
51B:B:T34 3.294595
52B:B:I37 4.4492
53B:B:V40 4.2425493
54B:B:I43 3.385403
55B:B:M45 4.444104
56B:B:L51 7.714559
57B:B:H54 9.7559
58B:B:Y59 8.648538
59B:B:W63 7.3025407
60B:B:L70 4.875455
61B:B:V71 4.54408
62B:B:D76 5.324559
63B:B:K78 6.4025408
64B:B:L79 4.088587
65B:B:I81 4.288587
66B:B:W82 10.696559
67B:B:Y85 12.6375454
68B:B:N88 6.295407
69B:B:K89 6.92286759
70B:B:H91 5.62485
71B:B:I93 6.5487
72B:B:L95 5.8475488
73B:B:W99 7.475819
74B:B:Y105 4.085686
75B:B:N110 6.47414
76B:B:Y111 6.695414
77B:B:V112 4.5025488
78B:B:L117 4.13419
79B:B:N119 4.9025419
80B:B:I123 4.116516
81B:B:Y124 5.52857786
82B:B:L126 4.93485
83B:B:E130 5.1854193
84B:B:V133 6.5225484
85B:B:H142 7.17143719
86B:B:Y145 5.92571718
87B:B:C148 3.89466
88B:B:F151 4.63167619
89B:B:I157 4.588517
90B:B:T159 6.025419
91B:B:S160 4.42466
92B:B:D163 7.434519
93B:B:W169 8.77833618
94B:B:Q176 7.114514
95B:B:F180 6.754567
96B:B:H183 8.878569
97B:B:V187 4.426569
98B:B:L190 4.2525465
99B:B:L192 5.28465
100B:B:F199 7.332569
101B:B:V200 6.5975476
102B:B:S201 4.915469
103B:B:D205 7.6775469
104B:B:K209 9.114566
105B:B:L210 4.12405
106B:B:W211 9.162568
107B:B:C218 4.8275465
108B:B:R219 6.885405
109B:B:F222 7.87578
110B:B:H225 8.73143779
111B:B:I232 6.2575478
112B:B:F235 6.733336136
113B:B:N237 6.65254135
114B:B:F241 8.752576
115B:B:T243 7.305478
116B:B:D247 7.63579
117B:B:R251 9.35667678
118B:B:F253 7.27833676
119B:B:R256 8.21409
120B:B:D258 11.305477
121B:B:M262 5.08404
122B:B:Y264 7.292505
123B:B:F278 6.0125137
124B:B:L285 5.095406
125B:B:Y289 6.84833637
126B:B:D290 8.1275436
127B:B:N295 6.646536
128B:B:V296 3.915405
129B:B:K301 4.324595
130B:B:H311 8.1445109
131B:B:R314 10.0875438
132B:B:L318 4.9625406
133B:B:W332 9.40714739
134B:B:D333 7.41754109
135B:B:K337 6.1885106
136B:B:W339 8.4385109
137G:G:V16 2.6275407
138G:G:E22 6.1225469
139G:G:V30 2.7725148
140G:G:Y40 8.8454136
141G:G:D48 7.625409
142G:G:P49 4.2925407
143G:G:L51 4.562596
144G:G:V54 5.36754236
145G:G:P60 9.08459
146G:G:F61 5.67667658
147L:L:?1 7.9751420
148R:R:F33 4.776507
149R:R:V50 4.7485155
150R:R:Y59 4.6625407
151R:R:K61 4.4625406
152R:R:N62 8.5854169
153R:R:D67 5.8225409
154R:R:F74 4.48333608
155R:R:K77 7.205427
156R:R:W87 10.205409
157R:R:Y102 8.95425
158R:R:Y106 11.9575428
159R:R:F111 6.946676168
160R:R:F112 8.6475409
161R:R:I115 5.96429
162R:R:S116 5.83429
163R:R:R119 6.274529
164R:R:Y120 9.105408
165R:R:P126 6.36754257
166R:R:Y137 5.4475403
167R:R:W146 5.3265169
168R:R:E174 5.3985245
169R:R:K176 3.26404
170R:R:W183 5.3475402
171R:R:N188 9.9125424
172R:R:F191 10.8975405
173R:R:F195 13.084529
174R:R:F199 5.89527
175R:R:F205 4.38508
176R:R:Y206 8.10833629
177R:R:I235 5.6025408
178R:R:F242 5.264529
179R:R:F246 6.61529
180R:R:Y249 9.965627
181R:R:H250 11.9933628
182R:R:R253 8.84714726
183R:R:Y256 8.72625
184R:R:S259 4.52423
185R:R:Y265 6.3325401
186R:R:K277 7.594525
187R:R:N287 7.9825409
188R:R:Y295 9.25429
189R:R:F302 3.77754159
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:M61 19.10652.83YesNo056
2B:B:C317 B:B:M61 19.19924.86NoNo076
3B:B:C317 B:B:S316 19.29723.44NoNo079
4B:B:S316 B:B:W332 19.43254.94NoYes099
5A:A:W258 B:B:W332 18.17832.81YesYes359
6A:A:F259 A:A:W258 38.60654.01YesYes395
7A:A:F259 A:A:I221 38.95458.79YesNo398
8A:A:I221 A:A:I253 39.67942.94NoNo088
9A:A:I253 A:A:L39 39.21795.71NoNo089
10A:A:F223 A:A:L39 57.0784.87YesNo099
11A:A:F223 A:A:F250 54.26539.65YesYes499
12A:A:F250 A:A:I319 48.99345.02YesYes495
13A:A:I319 A:A:N311 99.62157.08YesYes458
14A:A:K314 A:A:N311 1002.8NoYes038
15A:A:K314 R:R:R222 99.884912.38NoNo032
16A:A:E318 R:R:R222 99.602212.79YesNo2142
17A:A:E318 A:A:Y320 99.09295.61YesYes047
18A:A:D341 A:A:Y320 89.68275.75NoYes087
19A:A:D341 A:A:K345 89.513312.44NoYes085
20A:A:K345 A:A:K349 88.62597.18YesYes055
21A:A:K349 R:R:Q300 90.21825.42YesNo055
22A:A:D350 R:R:Q300 90.0872.61NoNo045
23A:A:D350 R:R:K122 89.95574.15NoNo048
24R:R:R119 R:R:Y206 10.63978.23YesYes299
25A:A:F223 A:A:L266 53.54813.65YesYes499
26A:A:I319 A:A:L266 48.99382.85YesYes459
27R:R:D118 R:R:K122 81.73964.15NoNo088
28R:R:D118 R:R:F56 81.60374.78NoNo088
29R:R:F56 R:R:L60 78.4484.87NoNo088
30R:R:I115 R:R:L60 78.30924.28YesNo098
31A:A:F215 B:B:W99 16.461610.02YesYes199
32A:A:F215 A:A:L37 17.62214.61YesNo199
33A:A:Q204 A:A:W211 51.3233.29YesYes199
34A:A:Q204 B:B:N119 25.64095.28YesYes199
35A:A:L249 A:A:R208 50.68053.64NoYes099
36B:B:H62 B:B:Y105 14.94583.27NoYes066
37B:B:H62 B:B:R150 14.76714.67NoNo066
38B:B:L192 B:B:R150 12.29774.86YesNo056
39B:B:F199 B:B:W211 23.510912.03YesYes698
40B:B:C218 B:B:W211 18.67095.22YesYes658
41B:B:C218 G:G:E22 16.82433.04YesYes659
42G:G:E22 G:G:L19 15.91182.65YesNo099
43B:B:L14 G:G:L19 14.97724.15NoNo089
44B:B:L14 G:G:K20 14.042511.28NoNo086
45G:G:K20 G:G:V16 12.17243.04NoYes067
46B:B:V112 B:B:Y105 12.29813.79YesYes886
47B:B:V112 B:B:Y124 11.81463.79YesYes886
48B:B:M325 G:G:P49 12.88828.39NoYes057
49G:G:D48 G:G:P49 12.13793.22YesYes097
50B:B:D290 B:B:R314 21.468815.48YesYes368
51B:B:C271 B:B:D290 20.95346.22NoYes356
52B:B:C271 B:B:Y289 20.37824.03NoYes357
53B:B:W297 B:B:Y289 18.44053.86NoYes387
54B:B:W297 B:B:Y264 18.437913.5NoYes085
55B:B:M262 B:B:Y264 14.60128.38YesYes045
56B:B:L30 B:B:M262 14.01385.65YesYes054
57B:B:L70 B:B:W63 14.81525.69YesYes057
58B:B:T321 B:B:W63 10.785810.92NoYes077
59B:B:D323 B:B:T321 10.284910.12NoNo2277
60B:B:D323 B:B:M325 10.200111.09NoNo075
61B:B:S122 B:B:Y124 15.29756.36NoYes886
62B:B:I120 B:B:S122 15.36563.1NoNo868
63B:B:D118 B:B:I120 15.88127NoNo096
64B:B:D118 B:B:S97 16.013310.31NoNo098
65B:B:C148 B:B:T102 40.99383.38YesNo068
66B:B:C149 B:B:T102 41.66316.76NoNo088
67B:B:C149 B:B:I157 15.50543.27NoYes087
68B:B:G144 B:B:N119 25.17773.39NoYes089
69B:B:C121 B:B:C149 26.84153.64NoNo088
70B:B:C121 B:B:L146 13.64013.17NoNo187
71B:B:C121 B:B:T159 13.63883.38NoYes189
72B:B:I157 B:B:W169 19.563.52YesYes178
73B:B:H142 B:B:L146 13.87745.14YesNo197
74B:B:H142 B:B:T159 13.87516.85YesYes199
75B:B:H142 B:B:W169 20.14147.41YesYes198
76B:B:G162 B:B:Y145 25.39437.24NoYes198
77B:B:G162 B:B:S161 25.35283.71NoNo199
78B:B:H142 B:B:S161 25.087115.34YesNo199
79B:B:D163 B:B:G144 25.03455.03YesNo098
80B:B:C148 B:B:S160 14.74073.44YesYes666
81B:B:C148 B:B:L190 23.33573.17YesYes665
82B:B:S160 B:B:V187 13.15874.85YesYes669
83R:R:I115 R:R:Y59 28.144.84YesYes097
84R:R:F111 R:R:Y59 27.11754.13YesYes087
85R:R:F111 R:R:W146 13.61655.01YesYes1689
86R:R:V107 R:R:W146 11.996711.03NoYes079
87R:R:M149 R:R:V107 11.82113.04NoNo087
88R:R:F191 R:R:M149 11.49434.98YesNo058
89L:L:?1 R:R:F191 11.15823.08YesYes005
90R:R:I115 R:R:Y295 44.62268.46YesYes299
91R:R:F112 R:R:Y295 44.799115.47YesYes099
92R:R:F112 R:R:F242 17.80493.22YesYes099
93R:R:H250 R:R:Y249 11.862814.16YesYes287
94R:R:F111 R:R:I63 12.91433.77YesNo089
95R:R:D67 R:R:I63 25.44094.2YesNo099
96R:R:D67 R:R:V288 36.67564.38YesNo098
97R:R:M70 R:R:V288 36.13793.04NoNo078
98R:R:F101 R:R:M70 34.94798.71NoNo077
99R:R:F101 R:R:F74 15.63855.36NoYes078
100R:R:F112 R:R:I63 13.11137.54YesNo099
101R:R:D291 R:R:F112 14.63648.36NoYes099
102R:R:D291 R:R:D67 12.90247.98NoYes099
103R:R:F101 R:R:T73 19.22365.19NoNo077
104R:R:S97 R:R:T73 18.66113.2NoNo057
105R:R:F76 R:R:S97 18.09847.93NoNo065
106R:R:F76 R:R:F92 17.53557.5NoNo063
107R:R:F92 R:R:V96 16.972510.49NoNo034
108R:R:R95 R:R:V96 15.84583.92NoNo084
109R:R:N161 R:R:R95 15.28239.64NoNo048
110R:R:N161 R:R:V91 10.7575.91NoNo043
111A:A:L37 A:A:L39 17.95085.54NoNo099
112B:B:S97 B:B:W99 16.14893.71NoYes089
113A:A:R208 A:A:W211 51.13767YesYes099
114B:B:D163 B:B:H142 24.32188.82YesYes199
115A:A:F223 A:A:L249 50.69726.09YesNo099
116A:A:Q204 B:B:Y145 25.2597.89YesYes198
117A:A:W258 B:B:R314 19.78894YesYes358
118B:B:F199 B:B:L190 21.86554.87YesYes695
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:K77 3.56 2 Yes Yes 0 7 0 1
L:L:?1 R:R:D81 7.54 2 Yes No 0 5 0 1
L:L:?1 R:R:V93 3.01 2 Yes No 0 6 0 1
L:L:?1 R:R:A98 3.18 2 Yes No 0 6 0 1
L:L:?1 R:R:V99 4.52 2 Yes No 0 6 0 1
L:L:?1 R:R:Y102 18.95 2 Yes Yes 0 5 0 1
L:L:?1 R:R:N156 11.1 2 Yes No 0 5 0 1
L:L:?1 R:R:C172 14.43 2 Yes No 0 9 0 1
L:L:?1 R:R:H184 10.39 2 Yes No 0 3 0 1
L:L:?1 R:R:N188 11.1 2 Yes Yes 0 4 0 1
L:L:?1 R:R:F191 3.08 2 Yes Yes 0 5 0 1
L:L:?1 R:R:R253 7.98 2 Yes Yes 0 6 0 1
L:L:?1 R:R:Y256 3.55 2 Yes Yes 0 5 0 1
L:L:?1 R:R:K277 9.26 2 Yes Yes 0 5 0 1
R:R:K77 R:R:Y29 14.33 2 Yes No 7 8 1 2
R:R:D81 R:R:K77 5.53 2 No Yes 5 7 1 1
R:R:E278 R:R:K77 5.4 2 No Yes 5 7 2 1
R:R:D81 R:R:E278 3.9 2 No No 5 5 1 2
R:R:C172 R:R:C94 7.28 0 No No 9 9 1 2
R:R:I157 R:R:V99 7.68 0 No No 5 6 2 1
R:R:Y102 R:R:Y249 4.96 2 Yes Yes 5 7 1 2
R:R:R253 R:R:Y102 7.2 2 Yes Yes 6 5 1 1
R:R:L281 R:R:Y102 4.69 2 No Yes 6 5 2 1
R:R:F191 R:R:Y106 25.79 0 Yes Yes 5 8 1 2
R:R:Y106 R:R:Y249 3.97 2 Yes Yes 8 7 2 2
R:R:F191 R:R:M149 4.98 0 Yes No 5 8 1 2
R:R:F191 R:R:L152 9.74 0 Yes No 5 5 1 2
R:R:N156 R:R:W183 5.65 0 No Yes 5 2 1 2
R:R:N156 R:R:S187 5.96 0 No No 5 4 1 2
R:R:H184 R:R:N188 8.93 2 No Yes 3 4 1 1
R:R:N188 R:R:R253 10.85 2 Yes Yes 4 6 1 1
R:R:N188 R:R:T257 8.77 2 Yes No 4 5 1 2
R:R:R253 R:R:Y249 17.49 2 Yes Yes 6 7 1 2
R:R:L281 R:R:Y249 11.72 2 No Yes 6 7 2 2
R:R:R253 R:R:Y256 8.23 2 Yes Yes 6 5 1 1
R:R:R253 R:R:T257 6.47 2 Yes No 6 5 1 2
R:R:K277 R:R:R253 3.71 2 Yes Yes 5 6 1 1
R:R:S259 R:R:Y256 3.82 2 Yes Yes 3 5 2 1
R:R:Q260 R:R:Y256 16.91 2 No Yes 3 5 2 1
R:R:R274 R:R:Y256 3.09 0 No Yes 3 5 2 1
R:R:K277 R:R:Y256 16.72 2 Yes Yes 5 5 1 1
R:R:Q260 R:R:S259 7.22 2 No Yes 3 3 2 2
R:R:E278 R:R:K277 4.05 2 No Yes 5 5 2 1
R:R:K277 R:R:L281 4.23 2 Yes No 5 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
72.22Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
68.75Single9YDVMRS29059YDV-P2Y14-MRS2905-Gi1/β1/γ2
68.42Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
64.71Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
58.82Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
55.56Single4PY02MeSATP4PY0-P2Y12-2MeSATP
55.56Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
55.56Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
55.56Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
52.63Single9J0BUDP-Glucose9J0B-P2Y14-UDP-Glucose-Gi1/β1/γ2
50.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single4NTJAZD12834NTJ-P2Y12-AZD1283
42.86Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
42.11Single6DDEDAMGO6DDE-μ-DAMGO-Gi1/β1/γ2
42.11Single8XBIPubChem 1626566368XBI-GPR34-PubChem 162656636
42.11Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
41.18Single8K4NPubChem 1687197658K4N-GPR34-PubChem 168719765-Gi1/β1/γ2
41.18Single8K9LDAMGO8K9L-μ-DAMGO-BMS-986122-Gi3/β1/γ1
40.91Single8WKYPG-9348WKY-MC4-PG-934
40.91Single8XBHPubChem 1626566368XBH-GPR34-PubChem 162656636-Gi1/β1/γ2
40.91Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
40.91Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
40.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
40.00Single9YDQDADLE9YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
40.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
40.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
40.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
39.13Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
39.13Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
39.13Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
39.13Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.89Single7NA8Ibutamoren7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
38.89Single8XBGS3E-Lysophosphatidylserine 8XBG-GPR34-S3E-Lysophosphatidylserine
38.10Single6DDFDAMGO6DDF-μ-DAMGO-Gi1/β1/γ2
38.10Single8WRZAM8418WRZ-CB1-AM841-Arrestin2
38.10Single9VI9RFRP-39VI9-NPFF1-RFRP-3-Gi1/β1/γ2
38.10Single9YDPDADLE9YDP-δ-DADLE-chim(NtGi1L-Gs-CtGi1)/β1/γ2
38.10Single9YDRDADLE9YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
37.50Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
36.84Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
36.84Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
36.84Single8IZ4Lysophosphatidylserine (TJR)8IZ4-GPR34-Lysophosphatidylserine (TJR)-Gi1/β1/γ2
36.84Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
36.84Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
36.36Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
36.36Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
36.36Single8SAILysophosphatidylserine (S12)8SAI-GPR34-Lysophosphatidylserine (S12)-Gi1/β1/γ2
36.36Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
36.36Single9NS9TUG-13759NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
36.36Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single9WSXEndomorphin9WSX-μ-Endomorphin-Arrestin2
35.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
35.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
35.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
35.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
35.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
35.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
35.00Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
35.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
35.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
35.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
34.78Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
34.78Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
34.78Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
34.62Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single6KQICP559406KQI-CB1-CP55940-Org27569
33.33Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
33.33Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
33.33Single7PIVAfamelanotide7PIV-MC4-Afamelanotide-Gs/β1/γ2
33.33Single7YITNalfurafine7YIT-κ-Nalfurafine
33.33Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
33.33Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Single8K9KDAMGO8K9K-μ-DAMGO-Gi3/β1/γ1
33.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
33.33Single8WRBLysophosphatidylserine (UBL)8WRB-GPR34-Lysophosphatidylserine (UBL)-Gi1/β1/γ2
33.33Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single9ECJS-geranylgeranyl-L-glutathione9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
33.33Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
33.33Single9K1DButyric acid9K1D-FFA2-Butyric acid-Gi1/β1/γ2
33.33Single9L60Dynorphin9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
33.33Single9U80Conivaptan9U80-V2-Conivaptan
33.33Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
33.33Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
33.33Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
33.33Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
33.33Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
32.26Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
32.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
32.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
32.00Single6PT2KGCHM076PT2-δ-KGCHM07
32.00Single6W25SHU91196W25-MC4-SHU9119-Ca
32.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
32.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
31.82Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
31.82Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
31.82Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
31.82Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single8XBES3E-Lysophosphatidylserine 8XBE-GPR34-S3E-Lysophosphatidylserine-Gi1/β1/γ1
31.82Single8ZPLHF511168ZPL-CXCR4-HF51116
31.82Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.82Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
31.82Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
31.82Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
31.58Single5ZKPSR274175ZKP-PAF-SR27417
31.58Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
31.58Single7V3ZCP559407V3Z-CB1-CP55940
31.25Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
31.03Single8KGGLysophosphatidylserine (WJS)8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
30.77Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.77Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
30.77Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
30.77Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
30.43Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.43Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
30.43Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
30.43Single8QJ2pN1628QJ2-MC4-pN162-Gs/β1/γ2
30.43Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
30.43Single9KZ2EP679KZ2-C3aB-EP67-Go/β1/γ2
30.43Single9KZ8EP679KZ8-C3aB-EP67-Go/β1/γ2
30.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
30.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
30.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
30.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
30.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
30.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
30.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.63Single7P02Substance-P7P02-NK1-Substance-P-chim(NtGi1-Gs)/β1/γ2
29.63Single7XV3Lysophosphatidylserine (WJS)7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
29.63Single7Y64C5a7Y64-C5a1-C5a-Gi1/β1/γ2
29.63Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
29.63Single8ZRTEndothelin-18ZRT-ETB-Endothelin-1
29.63Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
29.41Single9JLCAVE 09919JLC-MAS1-AVE 0991-Gi1/β1/γ2
29.17Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
29.17Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
29.17Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
29.17Single8IZBLysophosphatidylserine (UBL)8IZB-GPR174-Lysophosphatidylserine (UBL)-Gs/β1/γ2
29.17Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
29.17Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
29.17Consensuslpl_onOrthosteric Ligands1p_on lpa_on
29.17Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
29.17Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
29.17Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
29.17Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.03Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
29.03Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
28.57Single4DJHJDTic4DJH-κ-JDTic
28.57Single5XRAAM115425XRA-CB1-AM11542
28.57Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
28.57Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
28.57Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
28.57Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
28.57Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
28.57Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
28.57Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single8FMZNeurotensin-(8-13)8FMZ-NTS1-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.57Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
28.57Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
28.57Single9B65MDMB-Fubinaca9B65-CB1-MDMB-Fubinaca-Gi1/β1/γ2
28.57Single9EGOZ85267113509EGO-CB1-Z8526711350-Gi1/β1/γ2
28.57Single9IZGLPA9IZG-LPA1-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
28.57Single9KVPSB2901579KVP-C3aB-SB290157-Go/β1/γ2
28.57Single9PY3Loperamide9PY3-μ-Loperamide-GDPβS-Gi1/β1/γ2
28.57Single9WSTDAMGO9WST-μ-DAMGO-chim(NtGi1-Gz)/β1/γ2
28.57Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.57Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
28.57Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
28.57Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
28.57Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
28.57Consensuslpa_onOrthosteric Ligandlpa1_on
28.57Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
28.57Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
28.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
28.00Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
28.00Single9IK8Pasireotide9IK8-SST1-Pasireotide-Gi1/β1/γ2
28.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
28.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
28.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.78Single6B73MP11046B73-κ-MP1104
27.78Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
27.78Single7F8YDevazepide7F8Y-CCKA-Devazepide
27.78Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.78Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
27.78Single8T3VDoconexent8T3V-FFA1-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
27.78Single9LKDPL459LKD-OR5V1-PL45
27.59Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
27.59Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
27.59Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
27.59Single9KDFRES-701-39KDF-ETB-RES-701-3
27.59Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
27.59Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
27.59Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
27.59Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
27.27Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
27.27Single7EO4Siponimod7EO4-S1P1-Siponimod-Gi1/β1/γ2
27.27Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.27Single7W0LPubChem 1227019087W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
27.27Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8ID9Icosapent8ID9-FFA4-Icosapent-Gi1/β1/γ2
27.27Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
27.27Single8T3QDoconexent8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
27.27Single9CM3TUG-13759CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single9DGIZ85267113509DGI-CB1-Z8526711350
27.27Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
27.27Single9V6ONalfurafine9V6O-κ-Nalfurafine-Gi1/β1/γ2
27.27Single9W32SSTR5 antagonist 19W32-SST5-SSTR5 antagonist 1
27.27Single9WSVDAMGO9WSV-μ-DAMGO-Arrestin2
27.27Single9WSWEndomorphin9WSW-μ-Endomorphin-chim(NtGi1-Gz)/β1/γ2
27.27Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
27.27Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
27.27Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
26.92Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
26.92Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
26.92Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
26.92Single8K6NNeuropeptide-Y8K6N-Y2-Neuropeptide-Y-Gi2/β1/γ1
26.92Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single9B54VIP369B54-CB1-VIP36-Gi1/β1/γ2
26.92Single9MEUCXCL129MEU-CXCR4-CXCL12
26.92Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
26.92Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
26.92Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
26.92Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
26.67Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
26.32Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
26.32Single4MBSMaraviroc4MBS-CCR5-Maraviroc
26.32Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
26.32Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single8GURCP559408GUR-CB2-CP55940-Gi1/β1/γ2
26.32Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
26.32Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
26.32Single9LKBPL459LKB-OR5V1-PL45-chim(NtGi1-Gs)/β1
26.32Single9W33S5A19W33-SST5-S5A1
26.09Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
26.09Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
26.09Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
26.09Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
26.09Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
26.09Single8E0GBU728E0G-μ-BU72
26.09Single8GAGZ85267113508GAG-CB1-Z8526711350-Gi1/β1/γ2
26.09Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
26.09Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
26.09Single8JPFNeurotensin-(8-13)8JPF-NTS1-Neurotensin-(8-13)-SBI-553
26.09Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
26.09Single9IZFLPA9IZF-LPA1-LPA-Gi1/β1/γ2
26.09Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.09Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
26.09Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
26.09Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
25.93Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.93Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
25.93Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
25.93Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
25.93Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
25.93Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
25.93Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
25.81Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.81Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
25.81Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
25.71Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.71Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
25.00Single5UIGPubChem 1240811965UIG-A2A-PubChem 124081196
25.00Single5VBLAMG3054 5VBL-Apelin-AMG3054
25.00Single5ZTYAM102575ZTY-CB2-AM10257
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
25.00Single6KPFAM120336KPF-CB2-AM12033-Gi1/β1/γ2
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
25.00Single6Z4VNeurotensin-(9-13)6Z4V-NTS1-Neurotensin-(9-13)
25.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
25.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
25.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
25.00Single7RKFCX3CL17RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
25.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
25.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
25.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
25.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
25.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
25.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
25.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
25.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8HK5C5a8HK5-C5a1-C5a-Gi1/β1/γ2
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
25.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
25.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
25.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.00Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
25.00Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
25.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
25.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8ZYYNeurotensin-(8-13)8ZYY-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
25.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
25.00Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
25.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
25.00Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9KFTfMLFC9KFT-FPR1-ALX-fMLFC-Gi1/β1/γ2
25.00Single9M0RNeuropeptide-VF9M0R-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
25.00Single9PXWNaloxone9PXW-μ-Naloxone-GDPβS-Gi1/β1/γ2
25.00Consensusa3_onOrthosteric Liganda3a_on
25.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
25.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
25.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
25.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.14Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
24.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
24.00Single4XT1CX3CL14XT1-US28-CX3CL1
24.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
24.00Single7L0RNeurotensin-(8-13)7L0R-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
24.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
24.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
24.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
24.00Single8DWGBAM8-228DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
24.00Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
24.00Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
24.00Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
24.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
24.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
24.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.00Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
24.00Single9UMRC5a-pep9UMR-C5a1-C5a-pep-Go/β1/γ2
24.00Single9UYJChemerin-99UYJ-CML2-Chemerin-9-Arrestin2
24.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
23.81Single5C1MBU725C1M-μ-BU72
23.81Single6KPCAM120336KPC-CB2-AM12033
23.81Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
23.81Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
23.81Single6Z4SSR486926Z4S-NTS1-SR48692
23.81Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
23.81Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Single7VFXfMIFL7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
23.81Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.81Single7WIGL-0542647WIG-SST2-L-054264-Gi1/β1/γ2
23.81Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
23.81Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
23.81Single8JXSPF-61428JXS-D1-PF-6142
23.81Single8S4DCMF-0198S4D-Apelin-CMF-019
23.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
23.81Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
23.81Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
23.81Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
23.81Single9HAPTolvaptan9HAP-V2-Tolvaptan
23.81Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
23.81Single9L74S1P d16:19L74-S1P3-S1P d16:1-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single9U81Tolvaptan9U81-V2-Tolvaptan
23.81Consensusa3_on_gpOrthosteric Liganda3a_on_gp
23.81Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.81Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.81Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
23.81Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
23.81Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
23.81Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
23.53Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.33Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.33Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
23.33Single8ZH8QRFP268ZH8-QRFP-QRFP26-Gq/β1/γ1
23.33Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
23.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.33Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.08Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
23.08Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.08Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8K6ONeuropeptide-Y8K6O-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.08Single9KT7MK68929KT7-HCA2-MK6892-Gi1/β1/γ2
23.08Single9ME1CXCL129ME1-CXCR4-CXCL12
23.08Single9UMXEP549UMX-C5a1-EP54-Go/β1/γ2
23.08Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
23.08Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
23.08Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
23.08Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
23.08Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.08Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.73Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
22.73Single3ZEVNeurotensin-(7-13)3ZEV-NTS1-Neurotensin-(7-13)
22.73Single4BV0Neurotensin-(7-13)4BV0-NTS1-Neurotensin-(7-13)
22.73Single5TZRMK86665TZR-FFA1-MK8666
22.73Single5XR8AM120335XR8-CB1-AM12033
22.73Single6E59L-7607356E59-NK1-L-760735
22.73Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
22.73Single6J20Aprepitant6J20-NK1-Aprepitant
22.73Single6J21Aprepitant6J21-NK1-Aprepitant
22.73Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
22.73Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
22.73Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.73Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
22.73Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
22.73Single7L0PNeurotensin-(8-13)7L0P-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
22.73Single7L0QNeurotensin-(8-13)7L0Q-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
22.73Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
22.73Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
22.73Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
22.73Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
22.73Single8FN1Neurotensin-(8-13)8FN1-NTS1-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
22.73Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
22.73Single8HPTC5a (C-terminal peptide)8HPT-C5a1-C5a (C-terminal peptide)-Go/β1/γ2
22.73Single8HQCC5a8HQC-C5a1-C5a-Go/β1/γ2
22.73Single8I9LC3a8I9L-C3aB-C3a-Go/β1/γ2
22.73Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
22.73Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
22.73Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
22.73Single8WU1MDMB-Fubinaca8WU1-CB1-MDMB-Fubinaca-Arrestin2
22.73Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.73Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
22.73Single8ZWFJR14a8ZWF-C3aB-JR14a
22.73Single9BJKNaloxone9BJK-μ-Naloxone-PubChem 171642066
22.73Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single9I54PubChem 1764520919I54-D1-PubChem 176452091-Gs/β1/γ2
22.73Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
22.73Single9IK9Lanreotide9IK9-SST1-Lanreotide-Gi1/β1/γ2
22.73Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
22.73Single9PY4Loperamide9PY4-μ-Loperamide-GDPβS-Gi1/β1/γ2
22.73Consensusa2_onOrthosteric Liganda2b_on
22.73Consensusa2_on_gpOrthosteric Liganda2b_on_gp
22.73Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.73Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.73Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
22.73Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.73Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.73Consensusneurotensin_onOrthosteric Ligandnts1_on
22.73Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
22.73Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
22.73Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.73Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
22.73Consensustachykinin_offOrthosteric Ligandnk1_off
22.58Single6IGLIRL16206IGL-ETB-IRL1620
22.58Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.58Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.58Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.58Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.58Consensusbradykinin_onOrthosteric Ligandbk2_on
22.58Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
22.58Consensusendothelin_onOrthosteric Ligandetb_on eta_on
22.58Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single6HLLCP999946HLL-NK1-CP99994
22.22Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
22.22Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
22.22Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
22.22Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
22.22Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
22.22Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
22.22Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
22.22Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
22.22Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
22.22Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.22Single8XZGApelin-138XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
22.22Single8XZHMM078XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
22.22Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
22.22Single9KUWCMPD6449KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
22.22Single9M1ONeuropeptide-FF9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
22.22Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single9UYIChemerin-99UYI-CML2-Chemerin-9-Arrestin2
22.22Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
22.22Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.22Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.22Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
22.22Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
22.22Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
21.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.88Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.88Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
21.74Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
21.74Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
21.74Single4XEENeurotensin-(8-13)4XEE-NTS1-Neurotensin-(8-13)
21.74Single4XESNeurotensin-(8-13)4XES-NTS1-Neurotensin-(8-13)
21.74Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
21.74Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
21.74Single6MXTSalmeterol6MXT-β2-Salmeterol
21.74Single6OS0Angiotensin II6OS0-AT1-Angiotensin II
21.74Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
21.74Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
21.74Single7EW2FTY720-P7EW2-S1P3-FTY720-P-Gi1/β1/γ2
21.74Single7L0SNeurotensin-(8-13)7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
21.74Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
21.74Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
21.74Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
21.74Single8DWCBAM8-228DWC-MRGPRX1-BAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8JWZEtrumadenant8JWZ-A2A-Etrumadenant-Na
21.74Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.74Single8U26Substance-P8U26-NK1-Substance-P-Gs/β1/γ2
21.74Single8XYIVUF106618XYI-CXCR3-VUF10661
21.74Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
21.74Single9VIFNeuropeptide-VF9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
21.74Consensusalpha1_offOrthosteric Ligandalpha1a_off
21.74Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
21.74Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.74Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
21.74Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
21.74Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
21.74Consensuslpa_offOrthosteric Ligandlpa1_off
21.74Consensuslpl_offOrthosteric Ligands1p_off lpa_off
21.74Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
21.74Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
21.74Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
21.74Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
21.74Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
21.74Consensusorexin_onOrthosteric Ligandox2_on
21.74Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.74Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.74Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
21.74Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single6JODAngiotensin II6JOD-AT2-Angiotensin II
21.43Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
21.43Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
21.43Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
21.43Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
21.43Single8XZJWN3538XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
21.43Consensusapelin_onOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.43Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.43Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.43Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.43Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
21.43Consensusvasop-oxy_onOrthosteric Ligandv2_on
21.43Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
21.21Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
21.21Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
21.21Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.05Single3PWHZM-2413853PWH-A2A-ZM-241385
21.05Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
21.05Single5WS3EMPA5WS3-OX2-EMPA
21.05Single5ZKQABT-4915ZKQ-PAF-ABT-491
21.05Single6AKXA4R6AKX-CCR5-A4R
21.05Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.05Single6LFOCXCL86LFO-CXCR2-CXCL8-Gi1/β1/γ2
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7BR3Elagolix7BR3-GnRH1-Elagolix
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
21.05Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.05Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
21.05Single7XRRLemborexant7XRR-OX2-Lemborexant
21.05Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
21.05Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
21.05Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.05Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
21.05Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
21.05Single9KPESalicin9KPE-TAS2R16-Salicin-Gi1/β1/γ2
21.05Single9PXUNaloxone9PXU-μ-Naloxone-Na
21.05Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.05Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
21.05Consensusorexin_offOrthosteric Ligandox2_off ox1_off
21.05Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
21.05Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
21.05Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
21.05Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
21.05Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.83Single4BUONeurotensin-(8-13)4BUO-NTS1-Neurotensin-(8-13)
20.83Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
20.83Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.83Single5X93K-87945X93-ETB-K-8794
20.83Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.83Single6K1QIRL25006K1Q-ETB-IRL2500
20.83Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
20.83Single6UP7Neurotensin-(8-13)6UP7-NTS1-Neurotensin-(8-13)-Arrestin2
20.83Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
20.83Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.83Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.83Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.83Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single7Y65C5a (C-terminal peptide)7Y65-C5a1-C5a (C-terminal peptide)-Gi1/β1/γ2
20.83Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
20.83Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.83Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
20.83Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.83Single9KUGEP679KUG-C5a1-EP67-Go/β1/γ2
20.83Single9M54Neuropeptide-VF9M54-NPFF2-Neuropeptide-VF-Gi1/β1/γ2
20.83Single9UYMChemerin-99UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
20.83Single9WP9S1P9WP9-S1P3-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.83Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
20.83Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
20.83Consensusendothelin_offOrthosteric Ligandetb_off
20.83Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
20.83Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
20.69Single7F9YGhrelin7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8XQEApelin-138XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
20.69Consensusgi_apelinOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
20.69Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.59Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
20.00Single3REYPubChem 56973REY-A2A-PubChem 5697
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4UG2CGS216804UG2-A2A-CGS21680
20.00Single4XT3CX3CL14XT3-US28-CX3CL1
20.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
20.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.00Single6IQLL7458706IQL-D4-L745870
20.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6TPGEMPA6TPG-OX2-EMPA
20.00Single6TPNHTL66416TPN-OX2-HTL6641
20.00Single6VI4JDTic6VI4-κ-JDTic
20.00Single6ZINSR486926ZIN-NTS1-SR48692
20.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.00Single7VV6C48/807VV6-MRGPRX2-C48/80
20.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7XN9L-0545227XN9-SST2-L-054522
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
20.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
20.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
20.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100
20.00Single9ARXSerotonin9ARX-5-HT2A-Serotonin
20.00Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
20.00Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
20.00Single9IPYJR14a9IPY-C3aB-JR14a
20.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
20.00Single9JH3CMF-0199JH3-Apelin; Apelin-CMF-019-Gi1/β1/γ2
20.00Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
20.00Single9KPDSalicin9KPD-TAS2R16-Salicin-chim(Gs-CtGt3)/β1/γ2
20.00Single9KUWCMPD6449KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
20.00Single9KXSEP679KXS-C5a1-EP67-Go/β1/γ2
20.00Single9M2FNeuropeptide-FF9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
20.00Single9PXVNaloxone9PXV-μ-Naloxone-Gi1/β1/γ2
20.00Single9PXXNaloxone9PXX-μ-Naloxone-GDPβS-Gi1/β1/γ2
20.00Single9PY2Loperamide9PY2-μ-Loperamide-GDPβS-Gi1/β1/γ2
20.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
20.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
20.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
20.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
20.00Consensusgrh_offOrthosteric Ligandgnrh1_off
20.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
19.23Single4IARErgotamine4IAR-5-HT1B-Ergotamine
19.23Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
19.23Single7NA7Ghrelin7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2
19.23Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
19.23Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
19.23Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
19.23Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
19.23Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
19.23Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
19.23Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
19.23Single8KIGSHU91198KIG-MC3-SHU9119-Ca
19.23Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
19.23Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
19.23Single8XWNCXCL88XWN-CXCR2-CXCL8
19.23Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
19.23Single9KWGC5a9KWG-C5a1-C5a-Go/β1/γ2
19.23Single9L3YChemerin9L3Y-CML2-Chemerin-Gi1/β1/γ2
19.23Single9MEJGp1209MEJ-CXCR4-Gp120
19.23Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.23Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
19.05Single4YAYZD-71554YAY-AT1-ZD-7155
19.05Single5DHGC-355DHG-NOP-C-35
19.05Single5DHHSB-6121115DHH-NOP-SB-612111
19.05Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
19.05Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
19.05Single6TOTLemborexant6TOT-OX1-Lemborexant
19.05Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
19.05Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.05Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
19.05Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
19.05Single7JOZPubChem 752020227JOZ-D1-PubChem 75202022-Gs/β1/γ2
19.05Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
19.05Single7LJCSKF812977LJC-D1-SKF81297-Mevidalen-Gs/β1/γ2
19.05Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.05Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
19.05Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
19.05Single7UL4Alvimopan7UL4-μ-Alvimopan
19.05Single7VIFFTY720-P7VIF-S1P1-FTY720-P-Gi1/β1/γ2
19.05Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
19.05Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
19.05Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
19.05Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
19.05Single8EFQDAMGO8EFQ-μ-DAMGO-Gi1/β1/γ2
19.05Single8IC0CXCL88IC0-CXCR1-CXCL8-Gi1/β1/γ2
19.05Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
19.05Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
19.05Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
19.05Single8Y71A1D6F8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
19.05Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
19.05Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
19.05Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
19.05Single9H37PubChem 1756706469H37-A2A-PubChem 175670646-Na
19.05Single9KUXCMPD6449KUX-Apelin; Apelin-CMPD644-Arrestin2
19.05Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.05Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
19.05Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
19.05Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
19.05Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
19.05Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.05Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.05Consensusblt_onOrthosteric Ligandblt1_on
19.05Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
19.05Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
19.05Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
19.05Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
19.05Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
19.05Consensusleukotriene_onOrthosteric Ligandblt_on
19.05Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
19.05Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
19.05Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
19.05Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
18.75Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
18.75Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
18.75Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.52Single3QAKUK-4320973QAK-A2A-UK-432097
18.52Single6HLOAprepitant6HLO-NK1-Aprepitant
18.52Single7RKMCX3CL17RKM-US28-CX3CL1-Gi1/β1/γ2
18.52Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
18.52Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
18.52Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single8JZZC5a-des-Arg8JZZ-C5a1-C5a-des-Arg-Go/β1/γ2
18.52Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
18.52Single8WSSMCH8WSS-MCH1-MCH-Gi1/β1/γ1
18.52Single8Z7JJN241-98Z7J-Apelin-JN241-9-Gi1/β1/γ2
18.52Single9E82CXCL12 (fragment)9E82-ACKR3-CXCL12 (fragment)-Arrestin2
18.52Single9JFK(Pen5)-Urotensin II9JFK-UT-(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
18.52Single9KV6TLQP219KV6-C3aB-TLQP21-Go/β1/γ2
18.52Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.52Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
18.52Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
18.52Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
18.42Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
18.42Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
18.18Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
18.18Single5N2SPSB365N2S-A1-PSB36
18.18Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.18Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
18.18Single5WQCEMPA5WQC-OX2-EMPA
18.18Single5X7DCarazolol5X7D-β2-Carazolol-PubChem 129318963
18.18Single5XPRBosentan5XPR-ETB-Bosentan
18.18Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
18.18Single6HLPNetupitant6HLP-NK1-Netupitant
18.18Single6IGKEndothelin-36IGK-ETB-Endothelin-3
18.18Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
18.18Single6TP6Filorexant6TP6-OX1-Filorexant
18.18Single7C4SS1P7C4S-S1P3-S1P
18.18Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
18.18Single7EPFNAM5977EPF-mGlu2-NAM597
18.18Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
18.18Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
18.18Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
18.18Single7WC6LSD7WC6-5-HT2A-LSD
18.18Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
18.18Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.18Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
18.18Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
18.18Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8GNEKW-63568GNE-A2A-KW-6356-Na
18.18Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
18.18Single8TF5Oleic acid8TF5-GPR6-Oleic acid
18.18Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
18.18Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.18Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
18.18Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
18.18Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
18.18Single8ZJETAK4488ZJE-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ1
18.18Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
18.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9EHSLUF76029EHS-A3A-LUF7602
18.18Single9IYBPGD29IYB-DP2-PGD2-A1D5Q-Gi1/β1/γ2
18.18Single9KPFSalicin9KPF-TAS2R16-Salicin-Gi1/β1/γ2
18.18Single9KUVCMPD6449KUV-Apelin-CMPD644-Arrestin2
18.18Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
18.18Single9PXYNaloxone9PXY-μ-Naloxone-GDPβS-Gi1/β1/γ2
18.18Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.18Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Consensusbombesin_onOrthosteric Ligandbb2_on
18.18Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
18.18Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
18.18Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
18.18Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.18Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.86Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.86Single6MEOGp160; CD46MEO-CCR5-Gp160; CD4
17.86Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
17.86Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
17.86Consensusangiotensin_onOrthosteric Ligandat1_on
17.86Consensusat1_onOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
17.86Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.86Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
17.86Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single3RFMCaffeine3RFM-A2A-Caffeine
17.65Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.65Single9L0HJR14a9L0H-C3aB-JR14a-Go/β1/γ2
17.65Single9M42A1L8O9M42-GPR139-A1L8O-chim(Gs-CtGq)/β1/γ2
17.65Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.39Single3P0GBI1671073P0G-β2-BI167107
17.39Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
17.39Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
17.39Single6H7JIsoprenaline6H7J-β1-Isoprenaline
17.39Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.39Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
17.39Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
17.39Single6OS1TRV0266OS1-AT1-TRV026
17.39Single6TQ7SB-3348676TQ7-OX1-SB-334867
17.39Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
17.39Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
17.39Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
17.39Single7M8W15r-Methyl-PGD27M8W-DP2-15r-Methyl-PGD2-Na
17.39Single7R0CAVP7R0C-V2-AVP-Arrestin2
17.39Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
17.39Single7TUYGSK682753A7TUY-GPR183-GSK682753A
17.39Single7U2LC5-guano7U2L-μ-C5-guano-Gi1/β1/γ2
17.39Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
17.39Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7XOWSulfated Gastrin-(10-17)7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2
17.39Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
17.39Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
17.39Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
17.39Single8JZPC5a8JZP-C5a1-C5a-Go/β1/γ2
17.39Single8UGWCGS216808UGW-A2A-CGS21680
17.39Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
17.39Single8XVLZibotentan8XVL-ETA-Zibotentan
17.39Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
17.39Single8XZICMF-0198XZI-Apelin; Apelin-CMF-019-Gi1/β1/γ2
17.39Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
17.39Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
17.39Single9KUXCMPD6449KUX-Apelin; Apelin-CMPD644-Arrestin2
17.39Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
17.39Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.39Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
17.39Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.39Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
17.39Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.39Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.39Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
17.24Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.24Single6METGp160; CD46MET-CCR5-Gp160; CD4
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.24Single7F6G(Sar1)-Angiotensin II7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
17.24Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
17.24Single8WSTMCH8WST-MCH2-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Single8X8LCortistatin-148X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.24Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
17.24Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
17.24Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
17.24Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
16.67Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
16.67Single4LDEBI1671074LDE-β2-BI167107
16.67Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
16.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
16.67Single6YVRNeurotensin-(6-13)6YVR-NTS1-Neurotensin-(6-13)
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7DFPSpiperone7DFP-D2-Spiperone
16.67Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
16.67Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
16.67Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
16.67Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
16.67Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
16.67Single7W0LPubChem 1227019087W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
16.67Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
16.67Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
16.67Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
16.67Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.67Single8IA2C5a8IA2-C5a1-C5a-Go/β1/γ2
16.67Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
16.67Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
16.67Single8JJ8Arformoterol8JJ8-β2-Arformoterol
16.67Single8JJLOlodaterol8JJL-β2-Olodaterol
16.67Single8JJPChemerin-98JJP-CML2-Chemerin-9-Gi1/β1/γ2
16.67Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
16.67Single8JWY2-1188JWY-A2A-2-118
16.67Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
16.67Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
16.67Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
16.67Single8XQJJN2418XQJ-Apelin; Apelin-JN241
16.67Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.67Single8XWACXCL18XWA-CXCR2-CXCL1
16.67Single8XWMCXCL68XWM-CXCR2-CXCL6
16.67Single8XWSCXCL58XWS-CXCR2-CXCL5
16.67Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
16.67Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
16.67Single9JFYNeuropeptide-SF9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
16.67Single9JKT(2R)-2-hydroxy-3-phenylpropanoic acid9JKT-HCA3-(2R)-2-hydroxy-3-phenylpropanoic acid-Gi1/β1/γ2
16.67Single9KVG5-MeO-DMT9KVG-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
16.67Single9KZKC3a (fragment)9KZK-C3aB-C3a (fragment)-Go/β1/γ2
16.67Single9L3WChemerin9L3W-CML1-Chemerin-Gi1/β1/γ2
16.67Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
16.67Single9VJ6F-155999VJ6-5-HT1A-F-15599-Gi3/β1/γ2
16.67Single9WXMGPR15L(CT)9WXM-GPR15-GPR15L(CT)-Gi3/β1/γ2
16.67Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
16.67Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
16.67Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.67Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
16.67Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.67Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
16.67Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
16.67Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.67Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
16.67Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
16.67Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
16.67Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.67Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
16.22Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.13Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.13Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
16.13Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
16.13Single7SK3CXCL127SK3-ACKR3-CXCL12
16.13Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
16.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
16.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
16.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
16.00Single7EZCUK-4320977EZC-A2A-UK-432097
16.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
16.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
16.00Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8FN0Neurotensin-(8-13)8FN0-NTS1-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
16.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
16.00Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
16.00Single8XGSKisspeptin-18XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
16.00Single8XVUCXCL28XVU-CXCR2-CXCL2
16.00Single8XWFCXCL38XWF-CXCR2-CXCL3
16.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
16.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
16.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
16.00Single9HYIDP819HYI-5-HT1A-DP81-Gi1/β1/γ2
16.00Single9KT8Acifran9KT8-HCA2-Acifran-Gi1/β1/γ2
16.00Single9KWXC5a-des-Arg9KWX-C5a1-C5a-des-Arg-Go/β1/γ2
16.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.79Single3PBLEticlopride3PBL-D3-Eticlopride
15.79Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.79Single6TP4ACT-4622066TP4-OX1-ACT-462206
15.79Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
15.79Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.79Single7UL2SR486927UL2-NTS1-SR48692-Na
15.79Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
15.79Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
15.79Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
15.79Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
15.79Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
15.79Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.79Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
15.79Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8ZYUNeurotensin-(8-13)8ZYU-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
15.79Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
15.79Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
15.79Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
15.79Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
15.79Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
15.79Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
15.79Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
15.79Consensusneurotensin_offOrthosteric Ligandnts1_off
15.79Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
15.62Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
15.62Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
15.62Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
15.62Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
15.38Single5WF6UK-4320975WF6-A2A-UK-432097
15.38Single7RKNCX3CL17RKN-US28-CX3CL1-Gi1/β1/γ2
15.38Single7SK9CCX6627SK9-ACKR3-CCX662
15.38Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
15.38Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
15.38Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
15.38Single8X5YAstemizole8X5Y-H1-Astemizole
15.38Single8XQJJN2418XQJ-Apelin; Apelin-JN241
15.38Single8XZFWN5618XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
15.38Single9JF4PD1683689JF4-BB1-PD168368
15.38Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
15.38Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
15.38Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
15.38Consensuskisspeptin_onOrthosteric Ligandkiss1_on
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
15.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
15.00Single3ODUIT1t3ODU-CXCR4-IT1t
15.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
15.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
15.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.00Single5OLVLUAA470705OLV-A2A-LUAA47070-Na
15.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
15.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
15.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
15.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.00Single6TODEMPA6TOD-OX1-EMPA-Na
15.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
15.00Single7F8ULintitript7F8U-CCKA-Lintitript
15.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
15.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
15.00Single7T6STC-FPR 437T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2
15.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
15.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
15.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
15.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
15.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
15.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
15.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
15.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.00Single8DWGML3828DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
15.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
15.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
15.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
15.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
15.00Single8TZQDopamine8TZQ-D2-Dopamine-Go/β1/γ2
15.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
15.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
15.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
15.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
15.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
15.00Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
15.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
15.00Single9K6LSalicin9K6L-TAS2R16-Salicin-Gi2/β1/γ2
15.00Single9LLBDOI-NBOMe9LLB-5-HT2A-DOI-NBOMe-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
15.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
15.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
15.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
14.81Single7F8XNN90567F8X-CCKA-NN9056
14.81Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
14.81Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
14.81Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
14.81Single8WDTphotoNECA8WDT-A2A-photoNECA
14.81Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
14.81Single8ZJDKisspeptin-18ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
14.81Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
14.81Single9M4TSilodosin9M4T-Alpha1A-Silodosin
14.81Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
14.81Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
14.81Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
14.81Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
14.81Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
14.81Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
14.81Consensussomatostatin_offOrthosteric Ligandsst2_off
14.81Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.71Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
14.71Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
14.63Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
14.29Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
14.29Single4LDOEpinephrine4LDO-β2-Epinephrine
14.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
14.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
14.29Single5JTBZM-2413855JTB-A2A-ZM-241385
14.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
14.29Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
14.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
14.29Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
14.29Single5UVIZM-2413855UVI-A2A-ZM-241385
14.29Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
14.29Single6AQFZM-2413856AQF-A2A-ZM-241385
14.29Single6DO1(Sar1,Ile8)-Angiotensin II6DO1-AT1-(Sar1,Ile8)-Angiotensin II
14.29Single6MH8ZM-2413856MH8-A2A-ZM-241385
14.29Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
14.29Single6PS0Carazolol6PS0-β2-Carazolol
14.29Single6PS4ICI118-5516PS4-β2-ICI118-551
14.29Single6PS5Propranolol6PS5-β2-Propranolol
14.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
14.29Single6TPKRetosiban6TPK-OT-Retosiban
14.29Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.29Single6V9SGTPL114036V9S-OX1-GTPL11403
14.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.29Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
14.29Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
14.29Single6ZG9GSK10347026ZG9-M1-GSK1034702
14.29Single7AROLUF58337ARO-A2A-LUF5833-Na
14.29Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
14.29Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
14.29Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
14.29Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
14.29Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
14.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
14.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
14.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
14.29Single7F1QCCL37F1Q-CCR5-CCL3-Gi1/β1/γ2
14.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
14.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
14.29Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7SK5CXCL127SK5-ACKR3-CXCL12
14.29Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29Single7XNACYN1548067XNA-SST2-CYN154806
14.29Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
14.29Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
14.29Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
14.29Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
14.29Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
14.29Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
14.29Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
14.29Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IYXYL-3658IYX-GPR34-YL-365
14.29Single8JEIPubChem 117155568JEI-HCAR3-PubChem 11715556-Gi1/β1/γ2
14.29Single8JIMMonomethyl fumarate8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2
14.29Single8K2WAMG4878K2W-CXCR3-AMG487
14.29Single8K5CAcipimox8K5C-HCA2-Acipimox
14.29Single8RLNLUF58348RLN-A2A-LUF5834
14.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
14.29Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
14.29Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
14.29Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
14.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8U02Dopamine8U02-D2-Dopamine-Go/β1/γ2
14.29Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
14.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
14.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
14.29Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
14.29Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
14.29Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
14.29Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
14.29Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
14.29Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
14.29Single9JKYAcifran9JKY-HCA2-Acifran-Gi1/β1/γ2
14.29Single9L84Epinephrine9L84-β1-Epinephrine-Atazanavir-Gs/β1/γ2
14.29Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
14.29Single9ODJMitragynine Pseudoindoxyl9ODJ-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
14.29Single9ODLMitragynine Pseudoindoxyl9ODL-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
14.29Single9W6W5-CT9W6W-5-HT5A-5-CT-Gi1/β1/γ2
14.29Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA47070-Na 5N2R-A2A-PSB36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-Etrumadenant-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-PubChem 984073-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
14.29Consensusalpha1_onOrthosteric Ligandalpha1a_on
14.29Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
14.29Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
14.29Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
14.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
14.29Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
14.29Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
14.29Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
14.29Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
14.29Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
14.29Consensushca_onOrthosteric Ligandhca2_on
14.29Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
14.29Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
14.29Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
14.29Consensusvasop-oxy_offOrthosteric Ligandot_off
13.89Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
13.89Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
13.79Single5WF5UK-4320975WF5-A2A-UK-432097
13.79Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
13.79Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
13.64Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
13.64Single2Y02Carmoterol2Y02-β1-Carmoterol
13.64Single2Y04Salbutamol2Y04-β1-Salbutamol
13.64Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
13.64Single3EMLZM-2413853EML-A2A-ZM-241385
13.64Single3NY8ICI118-5513NY8-β2-ICI118-551
13.64Single3ZPQPubChem 5945903ZPQ-β1-PubChem 594590-Na
13.64Single3ZPRPubChem 5987543ZPR-β1-PubChem 598754-Na
13.64Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.64Single4GBRCarazolol4GBR-β2-Carazolol
13.64Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
13.64Single4QIMANTA XV4QIM-SMO-ANTA XV
13.64Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
13.64Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.64Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
13.64Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.64Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
13.64Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
13.64Single5T04Neurotensin-(8-13)5T04-NTS1-Neurotensin-(8-13)
13.64Single5UENDU1725UEN-A1-DU172
13.64Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
13.64Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.64Single6GPSMK08126GPS-CCR2-MK0812
13.64Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
13.64Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
13.64Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
13.64Single6PRZAlprenolol6PRZ-β2-Alprenolol
13.64Single6PS1Timolol6PS1-β2-Timolol
13.64Single6PS2Alprenolol6PS2-β2-Alprenolol
13.64Single6S0LZM-2413856S0L-A2A-ZM-241385
13.64Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.64Single7BTSEpinephrine7BTS-β1-Epinephrine
13.64Single7BU6Norepinephrine7BU6-β1-Norepinephrine
13.64Single7BU7BI1671077BU7-β1-BI167107
13.64Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
13.64Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
13.64Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.64Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
13.64Single7PYRPSB-21157PYR-A2A-PSB-2115
13.64Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
13.64Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
13.64Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
13.64Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.64Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.64Single7XJHIsoprenaline7XJH-β3-Isoprenaline-Gs/β1/γ2
13.64Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.64Single8CU6LJ-45178CU6-A2A-LJ-4517
13.64Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.64Single8GE2Constrained Epinephrine8GE2-β2-Constrained Epinephrine-Gs/β1/γ1
13.64Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
13.64Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
13.64Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
13.64Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
13.64Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
13.64Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
13.64Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
13.64Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
13.64Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
13.64Single8J6PNiacin8J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
13.64Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
13.64Single8JIINiacin8JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
13.64Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
13.64Single8JXRLSD8JXR-D1-LSD
13.64Single8K5DGSK2560738K5D-HCA2-GSK256073
13.64Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
13.64Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
13.64Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
13.64Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.64Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.64Single8X64Desloratadine8X64-H1-Desloratadine
13.64Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
13.64Single8ZQEGPR15L(CT)8ZQE-GPR15-GPR15L(CT)-Gi1/β1/γ1
13.64Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
13.64Single9CHXCarazolol9CHX-β2-Carazolol
13.64Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
13.64Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
13.64Single9LLAAriadne9LLA-5-HT2A-Ariadne-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single9METGp120; CD49MET-CXCR4-Gp120; CD4
13.64Single9P1SZM-2413859P1S-A2A-ZM-241385
13.64Single9PLNPubChem 1682595949PLN-α2a-PubChem 168259594
13.64Single9PLOPubChem 1682595949PLO-α2a-PubChem 168259594-Go/β1/γ2
13.64Single9PQDPubChem 1764919279PQD-α2a-PubChem 176491927
13.64Single9VMYTMU41429VMY-5-HT1A-TMU4142-Go/β1/γ2
13.64Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
13.64Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
13.64Consensus5ht5_onOrthosteric Ligand5ht5a_on
13.64Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.64Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
13.64Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
13.64Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
13.64Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
13.64Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
13.64Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
13.64Consensusdopamine_offOrthosteric Ligandd2_off d3_off
13.64Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
13.64Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
13.64Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
13.64Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
13.64Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
13.64Consensushca_on_gpOrthosteric Ligandhca2_on_gp
13.51Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.51Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
13.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.33Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
13.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
13.33Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.33Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
13.33Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
13.04Single2RH1Carazolol2RH1-β2-Carazolol
13.04Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.04Single2YCWCarazolol2YCW-β1-Carazolol
13.04Single5D6LCarazolol5D6L-β2-Carazolol
13.04Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.04Single5JQHCarazolol5JQH-β2-Carazolol
13.04Single5N2RPSB365N2R-A2A-PSB36-Na
13.04Single5TVNLSD5TVN-5-HT2B-LSD
13.04Single5WIUNemonapride5WIU-D4-Nemonapride
13.04Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.04Single6E67BI1671076E67-β2-BI167107-Gs(CT)
13.04Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
13.04Single6GPXMK08126GPX-CCR2-MK0812
13.04Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
13.04Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
13.04Single6PS3Carvedilol6PS3-β2-Carvedilol
13.04Single6S0QZM-2413856S0Q-A2A-ZM-241385
13.04Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
13.04Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
13.04Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
13.04Single7BVQCarazolol7BVQ-β1-Carazolol
13.04Single7C61Ergotamine7C61-5-HT1B-Ergotamine
13.04Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.04Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
13.04Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.04Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
13.04Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
13.04Single7W41PD1762527W41-BB2-PD176252
13.04Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
13.04Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
13.04Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.04Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.04Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
13.04Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
13.04Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
13.04Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
13.04Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
13.04Single8ZRKGSK12922638ZRK-GPR119-GSK1292263-Gs/β1/γ2
13.04Single8ZYTNeurotensin-(8-13)8ZYT-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
13.04Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
13.04Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
13.04Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
13.04Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
13.04Single9JKSPubChem 442501769JKS-HCA3-PubChem 44250176-Gi1/β1/γ2
13.04Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single9KO4CCL219KO4-CCR7-CCL21-Gi1/β1/γ2
13.04Single9KT6Acifran9KT6-HCA3-Acifran-Gi1/β1/γ2
13.04Single9KUTJR14a9KUT-C3aB-JR14a-Go/β1/γ2
13.04Single9M8POleic monoethanolamide9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
13.04Single9VJFBuspirone9VJF-5-HT1A-Buspirone-Gi3/β1/γ2
13.04Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
13.04Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
13.04Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.04Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
13.04Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.04Consensusadenosine_offOrthosteric Liganda1_off a2_off
13.04Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
13.04Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
13.04Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
13.04Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
13.04Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
13.04Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
13.04Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
13.04Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
13.04Consensusamine_offonOrthosteric Ligandamine_off amine_on
13.04Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
13.04Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
13.04Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
13.04Consensusbeta2_offOrthosteric Ligand2RH1-β2-Carazolol 6PS3-β2-Carvedilol 6PS5-β2-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-PubChem 913103 6PRZ-β2-Alprenolol
13.04Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
13.04Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
13.04Consensusblt_offOrthosteric Ligandblt1_off
13.04Consensusbombesin_offOrthosteric Ligandbb2_off
13.04Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
13.04Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.04Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
13.04Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
13.04Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
12.90Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
12.90Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
12.90Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
12.90Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
12.90Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
12.90Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
12.50Single2YDVNECA2YDV-A2A-NECA
12.50Single3PDSFAUC503PDS-β2-FAUC50
12.50Single4LDLHydroxybenzyl Isoproterenol4LDL-β2-Hydroxybenzyl Isoproterenol
12.50Single4UHRCGS216804UHR-A2A-CGS21680
12.50Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
12.50Single5D5ACarazolol5D5A-β2-Carazolol
12.50Single5D5BCarazolol5D5B-β2-Carazolol
12.50Single5G53NECA5G53-A2A-NECA-Gs
12.50Single5V54Methiothepin5V54-5-HT1B-Methiothepin
12.50Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.50Single6WGTLSD6WGT-5-HT2A-LSD
12.50Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
12.50Single7EW4CYM-55417EW4-S1P3-CYM-5541-Gi1/β1/γ2
12.50Single7PX4PSB-21137PX4-A2A-PSB-2113
12.50Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
12.50Single7VABTirzepatide (non-acylated)7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
12.50Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
12.50Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
12.50Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
12.50Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
12.50Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
12.50Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
12.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
12.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
12.50Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
12.50Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.50Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
12.50Single9BS9LSD9BS9-D2-LSD
12.50Single9BSBLSD9BSB-D2-LSD-chim(NtGi1-Go)/β1/γ2
12.50Single9JCLADP9JCL-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
12.50Single9L16CCL219L16-CCR7-CCL21
12.50Single9MENGp120 (V3 loop)9MEN-CXCR4-Gp120 (V3 loop)
12.50Consensus5ht1_offOrthosteric Ligand5ht1b_off
12.50Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
12.50Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
12.50Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-PubChem 594590-Na 3ZPR-β1-PubChem 598754-Na
12.50Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.50Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.50Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
12.50Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
12.12Single7EIBKallidin-des-Arg107EIB-BK1-Kallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.12Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.12Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
12.00Single3D4STimolol3D4S-β2-Timolol
12.00Single4AMIBucindolol4AMI-β1-Bucindolol
12.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.00Single4PXFOctyl-Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
12.00Single5X33BIIL2605X33-BLT1-BIIL260
12.00Single6A93Risperidone6A93-5-HT2A-Risperidone
12.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
12.00Single6OS2TRV0266OS2-AT1-TRV026
12.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
12.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
12.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
12.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
12.00Single7EPENAM5637EPE-mGlu2-NAM563
12.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
12.00Single7K15MKD0467K15-BLT1-MKD046-Na
12.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
12.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
12.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
12.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
12.00Single8FYTLSD8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1
12.00Single8HK2C3a8HK2-C3aB-C3a-Gi1/β1/γ2
12.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
12.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
12.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.00Single9BJKPubChem 1716420669BJK-μ-Naloxone-PubChem 171642066
12.00Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
12.00Single9M8POleic monoethanolamide9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
12.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
12.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
12.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
12.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
12.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
11.76Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
11.76Single6NBHLA-PTH Analog6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
11.76Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.76Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
11.76Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
11.76Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
11.76Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
11.76Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.76Single9JKVPubChem 27366909JKV-HCA3-PubChem 2736690-Gi1/β1/γ2
11.76Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
11.54Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
11.54Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
11.54Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
11.54Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.54Single6H7LDobutamine6H7L-β1-Dobutamine
11.54Single6IBLArformoterol6IBL-β1-Arformoterol
11.54Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
11.54Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
11.54Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
11.54Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
11.54Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
11.54Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
11.54Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
11.54Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
11.54Single8XVJMacitentan8XVJ-ETA-Macitentan
11.54Single9DYEBuspirone9DYE-5-HT1A-Buspirone-PtdIns4P-Go/β1/γ2
11.54Single9KV8TLQP219KV8-C3aB-TLQP21-Go/β1/γ2
11.54Single9UYHChemerin-99UYH-CML2-Chemerin-9-Arrestin2
11.54Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
11.54Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
11.54Consensuschemerin_onOrthosteric Ligandcml1_on
11.54Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
11.54Consensusprostanoid_offOrthosteric Ligandep_off dp_off
11.43Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
11.43Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
11.11Single3OE8IT1t3OE8-CXCR4-IT1t
11.11Single6KNMJN241-96KNM-Apelin-JN241-9
11.11Single6LPBPACAP276LPB-PAC1-PACAP27-Gs/β1/γ1
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
11.11Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.11Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
11.11Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
11.11Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.11Single8FLULA-PTH Analog8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
11.11Single8IWM2-Phenylethylamine8IWM-TAA9-2-Phenylethylamine
11.11Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
11.11Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.11Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9KX6C5a-des-Arg9KX6-C5a1-C5a-des-Arg-Go/β1/γ2
11.11Single9MD1Buspirone9MD1-5-HT1A-Buspirone-PtdIns4P-Gz/β1/γ2
11.11Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.11Consensusp2y_offOrthosteric Ligandp2y1_off
10.81Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.81Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.71Single4AMJCarvedilol4AMJ-β1-Carvedilol
10.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
10.71Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
10.53Single3OE6IT1t3OE6-CXCR4-IT1t
10.53Single3UZAGTPL92363UZA-A2A-GTPL9236
10.53Single4XNWMRS25004XNW-P2Y1-MRS2500
10.53Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.53Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.53Single6ME5Agomelatine6ME5-MT1-Agomelatine
10.53Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
10.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
10.53Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
10.53Single7Y36PTH7Y36-PTH1-PTH-Gs/β1/γ2
10.53Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
10.53Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8IW72-Phenylethylamine8IW7-TAA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.53Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.53Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
10.53Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.53Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
10.53Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.53Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
10.53Single9KT93,5-DHBA9KT9-HCA1-3,5-DHBA-Gi1/β1/γ2
10.53Consensus5ht2_onOrthosteric Ligand5ht2b_on
10.53Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.53Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.34Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
10.34Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
10.26Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
10.00Single3OE9IT1t3OE9-CXCR4-IT1t
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.00Single6VN7PACAP276VN7-VPAC1-PACAP27-Gs/β1/γ2
10.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2
10.00Single7SRQLSD7SRQ-5-HT2B-LSD
10.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
10.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
10.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
10.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
10.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
10.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
10.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
10.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
10.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
10.00Single8K5BNiacin8K5B-HCA2-Niacin
10.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
10.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
10.00Single9B5YLA-PTH Analog9B5Y-PTH1-LA-PTH Analog-chim(NtGi1-Gq)/β1/γ2
10.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
10.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
10.00Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
10.00Single9U9VMETH9U9V-β2-METH-Gs/β1/γ2
10.00Single9YDAAll-trans-Retinal9YDA-Opsin1MW-All-trans-Retinal-chim(NtGi1L-Gs-CtGt)/β1/γ2
10.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
10.00Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
10.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
10.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.68Single6M1IPACAP276M1I-PAC1-PACAP27-Gs/β1/γ2
9.68Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
9.68Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
9.68Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
9.52Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.52Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.52Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.52Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
9.52Single4BWBNeurotensin-(8-12)4BWB-NTS1-Neurotensin-(8-12)
9.52Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
9.52Single6DS0LY2660976DS0-5-HT2B-LY266097
9.52Single6ME2Ramelteon6ME2-MT1-Ramelteon
9.52Single6ME9Ramelteon6ME9-MT2-Ramelteon
9.52Single6OBAAlprenolol6OBA-β2-Alprenolol-GTPL11074
9.52Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
9.52Single7EJ0Norepinephrine7EJ0-α2a-Norepinephrine-Go/β1/γ2
9.52Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
9.52Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
9.52Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
9.52Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
9.52Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
9.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.52Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
9.52Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
9.52Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
9.52Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
9.52Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
9.52Single8GNGIstradefylline8GNG-A2A-Istradefylline
9.52Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
9.52Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
9.52Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
9.52Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
9.52Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
9.52Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
9.52Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
9.52Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
9.52Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
9.52Single8Y0HVUF114188Y0H-CXCR3-VUF11418
9.52Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
9.52Single8Z87CHBA8Z87-HCA1-CHBA-Gi1/β1/γ2
9.52Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
9.52Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
9.52Single9H2XPubChem 1756706449H2X-A2A-PubChem 175670644-Na
9.52Single9JKXAcifran9JKX-HCA3-Acifran-Gi1/β1/γ2
9.52Single9KVHCinobufotenine9KVH-5-HT1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
9.52Single9LL9DOI9LL9-5-HT2A-DOI-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
9.52Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
9.52Single9PEEPF-07054894; OXM29PEE-CCR6-PF-07054894; OXM2
9.52Single9VJ5Gepirone9VJ5-5-HT1A-Gepirone-Go/β1/γ2
9.52Single9VJEBuspirone9VJE-5-HT1A-Buspirone-Go/β1/γ2
9.52Single9W49U-50488H9W49-κ-U-50488H-Gi1/β1/γ2
9.52Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
9.52Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
9.52Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
9.52Consensusalpha2_offOrthosteric Ligandalpha2c_off
9.52Consensusangiotensin_offOrthosteric Ligandat1_off
9.52Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
9.52Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.52Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
9.52Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
9.38Single5YQZNNC17025YQZ-Glucagon-NNC1702
9.38Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
9.38Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
9.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
9.38Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
9.38Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
9.09Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
9.09Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.09Single3RZECidoxepin3RZE-H1-Cidoxepin
9.09Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
9.09Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
9.09Single6A94Zotepine6A94-5-HT2A-Zotepine
9.09Single6FJ3PTH6FJ3-PTH1-PTH
9.09Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.09Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
9.09Single6KUXRS799486KUX-α2a-RS79948
9.09Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
9.09Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
9.09Single6NBFLA-PTH Analog6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
9.09Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
9.09Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
9.09Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.09Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
9.09Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
9.09Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
9.09Single7F61PF-036547467F61-H3-PF-03654746
9.09Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
9.09Single7T32ZM-2413857T32-A2A-ZM-241385
9.09Single7UL3Famotidine7UL3-H2-Famotidine
9.09Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.09Single7UTZDPPC7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
9.09Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
9.09Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.09Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.09Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
9.09Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.09Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GE5Constrained Epinephrine8GE5-β2-Constrained Epinephrine-Gs/β1/γ1
9.09Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
9.09Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
9.09Single8IHKAcifran8IHK-HCA3-Acifran
9.09Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
9.09Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
9.09Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
9.09Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
9.09Single8THKA-616038THK-Alpha1A-A-61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
9.09Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
9.09Single8Y01All-trans-Retinal8Y01-Opsin1MW-All-trans-Retinal-Gi1/β1/γ2
9.09Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8ZBWQuin-C18ZBW-FPR2-ALX-Quin-C1-Gi2/β1/γ2
9.09Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
9.09Single8ZPMAMD0708ZPM-CXCR4-AMD070
9.09Single9AS3LSD9AS3-5-HT2A-LSD
9.09Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AS5Mescaline9AS5-5-HT2A-Mescaline
9.09Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
9.09Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
9.09Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.09Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
9.09Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
9.09Single9KVIBufotenin9KVI-5-HT1A-Bufotenin-PtdIns4P-Gi1/β1/γ2
9.09Single9L8LBI1671079L8L-β2-BI167107-Atazanavir-Gs/β1/γ2 ; Arrestin2
9.09Single9LL8Psilocin9LL8-5-HT2A-Psilocin-Gi1/β1/γ2
9.09Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
9.09Single9P1TZM-2413859P1T-A2A-ZM-241385
9.09Single9P92VIP9P92-PAC1-VIP-Gs/β1/γ2
9.09Single9VJG8-OH-DPAT9VJG-5-HT1A-8-OH-DPAT-chim(NtGi2-Gz)/β1/γ2
9.09Single9VNFPindolol9VNF-5-HT1A-Pindolol-Go/β1/γ2
9.09Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
9.09Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
9.09Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
9.09Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
8.82Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
8.82Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
8.82Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
8.82Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
8.82Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
8.82Single7S1MExendin-4-D-Ala7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
8.82Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
8.82Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
8.82Single8FU6ZP37808FU6-Glucagon-ZP3780-Gs/β1/γ2
8.82Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
8.70Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.70Single2Y01Dobutamine2Y01-β1-Dobutamine
8.70Single3NYAAlprenolol3NYA-β2-Alprenolol
8.70Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
8.70Single6DRXLisuride6DRX-5-HT2B-Lisuride
8.70Single6H7MSalbutamol6H7M-β1-Salbutamol
8.70Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
8.70Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
8.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.70Single7VGZRamelteon7VGZ-MT1-Ramelteon-Gi1/β1/γ2
8.70Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
8.70Single7WC7Lisuride7WC7-5-HT2A-Lisuride
8.70Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.70Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
8.70Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
8.70Single8JHNMonomethyl fumarate8JHN-HCA2-Monomethyl fumarate-Go/β1/γ2
8.70Single8JJOAlprenolol8JJO-β2-Alprenolol
8.70Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
8.70Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
8.70Single8T1WCVN4248T1W-GPR6-CVN424
8.70Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
8.70Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
8.70Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
8.70Single8X63Mepyramine8X63-H1-Mepyramine
8.70Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
8.70Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
8.70Single9DYFAsenapine9DYF-5-HT1A-Asenapine-PtdIns4P-Gi1/β1/γ2
8.70Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
8.70Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
8.70Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
8.70Single9UAZAtropine9UAZ-M1-Atropine
8.70Consensusalpha2_onOrthosteric Ligandalpha2b_on
8.70Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
8.70Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
8.70Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
8.70Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
8.70Consensushistamine_offOrthosteric Ligandh1_off
8.57Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
8.57Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
8.57Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
8.57Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
8.57Single9P93VIP9P93-PAC1-VIP-Gs/β1/γ2
8.57Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
8.57Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
8.57Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
8.57Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
8.33Single2Y00Dobutamine2Y00-β1-Dobutamine
8.33Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
8.33Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
8.33Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
8.33Single6D26Fevipiprant6D26-DP2-Fevipiprant
8.33Single6LFMCXCL86LFM-CXCR2-CXCL8-Gi1/β1/γ2
8.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
8.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
8.33Single6PS6Timolol6PS6-β2-Timolol
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
8.33Single8ZMFPubChem 1719206738ZMF-5-HT2C-PubChem 171920673
8.33Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
8.33Single9DYDAsenapine9DYD-5-HT1A-Asenapine-PtdIns4P-Go/β1/γ2
8.33Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.33Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
8.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
8.33Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
8.33Consensusdp_offOrthosteric Liganddp2_off
8.33Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
8.33Consensusep_offOrthosteric Ligandep4_off
8.33Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
8.33Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
8.33Consensustrace-amine_onOrthosteric Ligandta1_on
8.11Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
8.11Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
8.00Single4U15Tiotropium4U15-M3-Tiotropium
8.00Single5V56TC1145V56-SMO-TC114
8.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
8.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
8.00Single6OL9Tiotropium6OL9-M5-Tiotropium
8.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
8.00Single7F1TCCL37F1T-CCR5-CCL3
8.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
8.00Single8I2GPubChem 675302408I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
8.00Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
8.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
8.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
8.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
8.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
8.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
8.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-methyl-Scopolamine 5ZHP-M3-PubChem 134828589
8.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
8.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
8.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
8.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
8.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
7.89Single6WPWZP37806WPW-Glucagon-ZP3780-Gs/β1/γ2
7.89Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
7.89Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
7.89Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
7.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
7.89Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
7.69Single5CXVTiotropium5CXV-M1-Tiotropium
7.69Single6CM4Risperidone6CM4-D2-Risperidone
7.69Single6DRYMethylergometrine6DRY-5-HT2B-Methylergometrine
7.69Single6H7NXamoterol6H7N-β1-Xamoterol
7.69Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
7.69Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
7.69Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
7.69Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
7.69Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
7.69Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
7.69Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
7.69Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
7.69Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
7.69Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
7.69Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
7.50Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
7.41Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
7.41Single7D7MPGE27D7M-EP4-PGE2-Gs/β1/γ1
7.41Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
7.41Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
7.41Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
7.41Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
7.41Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
7.41Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
7.41Single9L79AR2314539L79-GPR119-AR231453-chim(NtGi1-Gs)/β1/γ2
7.41Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
7.32Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
7.14Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
7.14Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.14Single9UMJEP549UMJ-C3aB-EP54-Go/β1/γ2
7.14Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
6.90Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
6.90Single9UYLChemerin-99UYL-CML2-Chemerin-9-Arrestin2
6.67Single7VBITirzepatide (non-acylated)7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
6.52Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
6.45Single9LXRLA-PTH Analog9LXR-PTH1-LA-PTH Analog-Arrestin2
6.25Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
6.25Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
6.25Single8W8RAA-148W8R-GPR101-AA-14-chim(NtGi1-Gs)/β1/γ2
6.25Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
6.06Single8YG4LA-PTH Analog8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
6.06Single9E2AGLP-19E2A-GLP-1-GLP-1-Gs/β1/γ2
6.06Consensuspac_onOrthosteric Ligandpac1_on
6.06Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
5.88Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
5.88Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
5.88Single5MZPCaffeine5MZP-A2A-Caffeine-Na
5.88Single6NBILA-PTH Analog6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
5.88Single6P9YPACAP276P9Y-PAC1-PACAP27-Gs/β1/γ2
5.88Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
5.88Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
5.88Single9BLWCagrilintide (non-acylated)9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
5.88Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
5.88Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.88Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
5.88Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
5.88Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
5.71Single6P9XCorticoliberin-16P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
5.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
5.71Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
5.71Single9P94PACAP279P94-PAC1-PACAP27-Gs/β1/γ2
5.71Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
5.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
5.71Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
5.56Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
5.56Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
5.56Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
5.56Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
5.56Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
5.56Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
5.56Single7WC4Serotonin7WC4-5-HT2A-Serotonin
5.56Single7XKDDehydroepiandrosterone7XKD-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
5.56Single7XKEDehydroepiandrosterone7XKE-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
5.56Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.56Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
5.56Single8PWNTheophylline8PWN-A2A-Theophylline
5.56Single9JIDNiacin9JID-HCA3-Niacin-Gi1/β1/γ2
5.56Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.41Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
5.41Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
5.26Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
5.26Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.26Single8IKGPubChem 7032058IKG-CB1-PubChem 703205-Gi1/β1/γ1
5.26Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8Z8ALactate8Z8A-HCA1-Lactate-Gi1/β1/γ2
5.26Single9CHUNorepinephrine9CHU-β2-Norepinephrine
5.26Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
5.26Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
5.26Consensussensory_onOrthosteric Ligandopsins_on
5.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.00Single6PWCNeurotensin-(9-13)6PWC-NTS1-Neurotensin-(9-13)-Arrestin2
5.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
5.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.00Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
5.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8ITFDMCHA8ITF-TAA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
5.00Single8IU2All-trans-Retinal8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
5.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
5.00Single8JEFPubChem 113671668JEF-HCA3-PubChem 11367166-Gi1/β1/γ2
5.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
5.00Single8JPSCCL78JPS-ACKR1-CCL7
5.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
5.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8WG8Peptide8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/β1/γ2
5.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
5.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
5.00Single9JG1Adriforant9JG1-H4-Adriforant
5.00Single9LL7DOI9LL7-5-HT2A-DOI-Gi1/β1/γ2
5.00Single9LRCHistamine9LRC-H4-Histamine
5.00Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
5.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
5.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
5.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
5.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
5.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
4.88Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
4.76Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
4.76Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
4.76Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
4.76Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
4.76Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single5L7IVismodegib5L7I-SMO-Vismodegib
4.76Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
4.76Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.76Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
4.76Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
4.76Single8IKHPubChem 1713935418IKH-CB1-PubChem 171393541-Gi1/β1/γ1
4.76Single8W892-Phenylethylamine8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2
4.76Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
4.76Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
4.76Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
4.76Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
4.76Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9AS7Psilocin9AS7-5-HT2A-Psilocin
4.76Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single9EPRAll-trans-Retinal9EPR-Rhodopsin-All-trans-Retinal-Gi1/β1/γ2
4.76Single9JEDHistamine9JED-H4-Histamine-PO4-Gi1/β1/γ2
4.76Single9JEQHistamine9JEQ-H3-Histamine-Gi1/β1/γ2
4.76Single9L42Histamine9L42-H4-Histamine-Gi1/β1/γ2
4.76Single9M88Oleic monoethanolamide9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
4.76Single9MBCAZ122160529MBC-mGlu8; mGlu8-DCPG-AZ12216052
4.76Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.76Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.55Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.55Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single4XNVBPTU4XNV-P2Y1-BPTU
4.55Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.55Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
4.55Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.55Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.55Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
4.55Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.55Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
4.55Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
4.55Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
4.55Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
4.55Single8FYXBuspirone8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1
4.55Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
4.55Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
4.55Single8IW4Spermidine8IW4-TAA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
4.55Single8IWESpermidine8IWE-TAA9-Spermidine
4.55Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.55Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.55Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
4.55Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
4.55Single8Y71BMS9861878Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
4.55Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
4.55Single8YNFCXCL88YNF-ACKR1-CXCL8
4.55Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
4.55Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
4.55Single9KO2CCL199KO2-CCR7-CCL19-Gi1/β1
4.55Single9KO6CCL199KO6-CCR7-CCL19
4.55Single9M88Oleic monoethanolamide9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
4.55Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.55Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.55Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.55Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
4.55Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
4.55Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
4.55Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.55Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
4.55Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
4.55Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.35Single2YDOAdenosine2YDO-A2A-Adenosine
4.35Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
4.35Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.35Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
4.35Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
4.35Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
4.35Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
4.35Single8PM2DMCHA8PM2-TA7-DMCHA-Gs/β1/γ2
4.35Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
4.35Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
4.35Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
4.35Single9AS8Psilocin9AS8-5-HT2A-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
4.35Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
4.35Consensusopsins_offOrthosteric Ligandrhodopsin_off
4.35Consensussensory_offOrthosteric Ligandopsins_off
4.17Single4DAJTiotropium4DAJ-M3-Tiotropium
4.17Single4MQSIperoxo4MQS-M2-Iperoxo
4.17Single4U14Tiotropium4U14-M3-Tiotropium
4.17Single4U16N-methyl-Scopolamine4U16-M3-N-methyl-Scopolamine
4.17Single5DSGTiotropium5DSG-M4-Tiotropium
4.17Single5TGZAM65385TGZ-CB1-AM6538
4.17Single5YC8N-methyl-Scopolamine5YC8-M2-N-methyl-Scopolamine
4.17Single5ZK8N-methyl-Scopolamine5ZK8-M2-N-methyl-Scopolamine
4.17Single5ZKCN-methyl-Scopolamine5ZKC-M2-N-methyl-Scopolamine
4.17Single6D27CAY104716D27-DP2-CAY10471
4.17Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
4.17Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
4.17Single8GCML-9026888GCM-EP4-L-902688-Gi1/β1/γ2
4.17Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
4.17Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.17Single8Y73MPAM-158Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
4.17Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
4.17Single9AS1DMT9AS1-5-HT2A-DMT
4.17Single9IMATalquetamab9IMA-GPRC5D; GPRC5D-Talquetamab
4.17Single9JEAAtropine9JEA-M1-Atropine
4.17Single9YDQMIPS36149YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
4.17Single9YDRMIPS39839YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
4.17Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
4.17Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
4.17Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
4.17Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
4.17Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
4.17Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
4.00Single4JKVTaladegib4JKV-SMO-Taladegib
4.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
4.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
4.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
4.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
4.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
4.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
4.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
4.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
4.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
4.00Single9HC04YI9HC0-mGlu5-4YI
4.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
4.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
3.85Single5V57TC1145V57-SMO-TC114
3.85Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.85Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
3.85Single7P2L4YI7P2L-mGlu5-4YI
3.85Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
3.85Single8EA0Iperoxo8EA0-M3-Iperoxo
3.85Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0FVU298X0F-mGlu5; mGlu5-Quisqualate-VU29
3.85Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
3.85Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
3.85Single9AS9RS130-1809AS9-5-HT2A-RS130-180
3.85Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9RHGC4079RHG-FZD7-C407
3.85Single9UCPIperoxo9UCP-M1-Iperoxo-G11(CT)
3.85Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
3.70Single4N4WSANT-14N4W-SMO-SANT-1
3.70Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
3.70Single9EK0Iperoxo9EK0-M5-Iperoxo-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.57Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
3.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.33Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
3.23Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
3.23Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
3.12Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
3.12Single8YFOAc-LA-PTH Analog8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
3.12Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
3.12Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
3.03Single6NIYCalcitonin-16NIY-CT-Calcitonin-1-Gs/β1/γ2
3.03Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.03Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
3.03Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
3.03Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.94Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.86Single9BLBCagrilintide (non-acylated)9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
2.86Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
2.78Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
2.70Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
2.70Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
2.70Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
2.56Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.56Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.44Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.44Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.22Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.17Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3

PDB Summary
PDB 9YDU
Class A
SubFamily Nucleotide
Type P2Y
SubType P2Y14
Species Homo Sapiens
Ligand UDP-Glucose
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.19
Date 2025-11-19
D.O.I. 10.1038/s42003-025-09174-6
Net Summary
Imin 2.8
Number of Linked Nodes 849
Number of Links 1064
Number of Hubs 189
Number of Links mediated by Hubs 674
Number of Communities 25
Number of Nodes involved in Communities 272
Number of Links involved in Communities 405
Path Summary
Number Of Nodes in MetaPath 119
Number Of Links MetaPath 118
Number of Shortest Paths 1652492
Length Of Smallest Path 3
Average Path Length 34.2103
Length of Longest Path 64
Minimum Path Strength 1.13
Average Path Strength 6.24448
Maximum Path Strength 25.18
Minimum Path Correlation 0.7
Average Path Correlation 0.98436
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 41.0547
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.5158
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G protein-coupled UDP receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled pyrimidinergic nucleotide receptor activity   • nucleotide receptor activity   • G protein-coupled purinergic nucleotide receptor activity   • purinergic nucleotide receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell communication   • multicellular organismal process   • multicellular organismal-level homeostasis   • homeostatic process   • hematopoietic stem cell homeostasis   • homeostasis of number of cells   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • cell surface receptor signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • system process   • relaxation of smooth muscle   • regulation of system process   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • sperm principal piece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeUPG
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeUPG
NameUridine diphosphate glucose
SynonymsUridine diphosphate glucose
Identifier
FormulaC15 H24 N2 O17 P2
Molecular Weight566.302
SMILES
PubChem8629
Formal Charge0
Total Atoms60
Total Chiral Atoms9
Total Bonds62
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>9YDU_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG ASGKTIVKQ 
TGIVETHFT FKDLHFKMF DVGQRSERK KWIHCFEGV TAIIFCVAL 
SDYDLVLMN RMHSMKLFD SICNNKWFT DTSIILFLN KKDLFEEKI 
KKSPLTICY PEYAGSNTY EEAAAYIQC QFEDLNKRK DTKEIYTHF 
TCTDTKNVQ FVFDAVTDV IIKNNLKDC GLFNAAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9YDU_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9YDU_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ15391
Sequence
>9YDU_Chain_R
LLITQQIIP VLYCMVFIA GILLNGVSG WIFFYVPSS KSFIIYLKN 
IVIADFVMS LTFPFKILG DSGLGPWQL NVFVCRVSA VLFYVNMYV 
SIVFFGLIS FDRYYKIVK PLWTSFIQS VSYSKLLSV IVWMLMLLL 
AVPNIILTN QSVREVTQI KCIELKSEL GRKWHKASN YIFVAIFWI 
VFLLLIVFY TAITKKIFK SHLKSSRNS TSVKKKSSR NIFSIVFVF 
FVCFVPYHI ARIPYTKSQ TEAHYSCQS KEILRYMKE FTLLLSAAN 
VCLDPIIYF FLCQPFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9J0FANucleotideP2YP2Y14Homo sapiensNADH-Gi1/β1/γ22.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J0F (No Gprot) ANucleotideP2YP2Y14Homo sapiensNADH-2.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J0IANucleotideP2YP2Y14Homo sapiensUDP-Glucuronic acid-Gi1/β1/γ22.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J0I (No Gprot) ANucleotideP2YP2Y14Homo sapiensUDP-Glucuronic acid-2.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J0BANucleotideP2YP2Y14Homo sapiensUDP-Glucose-Gi1/β1/γ22.882025-06-0410.1038/s41421-025-00799-9
9J0B (No Gprot) ANucleotideP2YP2Y14Homo sapiensUDP-Glucose-2.882025-06-0410.1038/s41421-025-00799-9
9J05ANucleotideP2YP2Y14Homo sapiens---3.22025-08-06To be published
9YDU (No Gprot) ANucleotideP2YP2Y14Homo sapiensUDP-Glucose-3.192025-11-1910.1038/s42003-025-09174-6
9YDVANucleotideP2YP2Y14Homo sapiensMRS2905-Gi1/β1/γ23.052025-11-1910.1038/s42003-025-09174-6
9YDV (No Gprot) ANucleotideP2YP2Y14Homo sapiensMRS2905-3.052025-11-1910.1038/s42003-025-09174-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9YDU.zip



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