psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:K77	7.26	Yes	Yes	1	0	7
2	L:L:?1	R:R:D81	8.89	Yes	No	1	0	5
3	L:L:?1	R:R:A98	4.42	Yes	No	0	0	6
4	L:L:?1	R:R:V99	7.67	Yes	No	0	0	6
5	L:L:?1	R:R:Y102	23.03	Yes	Yes	1	0	5
6	L:L:?1	R:R:N156	14.77	Yes	No	1	0	5
7	L:L:?1	R:R:C172	9.65	Yes	No	0	0	9
8	L:L:?1	R:R:K176	3.96	Yes	Yes	1	0	4
9	L:L:?1	R:R:H184	6.62	Yes	Yes	1	0	3
10	L:L:?1	R:R:N188	5.78	Yes	Yes	1	0	4
11	L:L:?1	R:R:F191	5.13	Yes	Yes	0	0	5
12	L:L:?1	R:R:R253	5.11	Yes	Yes	1	0	6
13	L:L:?1	R:R:Y256	4.94	Yes	Yes	1	0	5
14	L:L:?1	R:R:Q260	7.47	Yes	Yes	1	0	3
15	L:L:?1	R:R:R274	8.52	Yes	Yes	1	0	3
16	L:L:?1	R:R:K277	7.26	Yes	Yes	1	0	5
17	L:L:?1	R:R:E278	8.06	Yes	No	1	0	5
18	R:R:L19	R:R:N17	8.24	No	No	0	3	5
19	R:R:L18	R:R:Q22	3.99	No	No	0	3	4
20	R:R:I20	R:R:T21	4.56	Yes	No	0	4	4
21	R:R:F279	R:R:I20	5.02	No	Yes	0	5	4
22	R:R:R274	R:R:T21	6.47	Yes	No	0	3	4
23	R:R:F279	R:R:I25	8.79	No	No	0	5	6
24	R:R:D81	R:R:P26	6.44	No	No	0	5	5
25	R:R:L28	R:R:L282	5.54	No	No	0	5	5
26	R:R:K77	R:R:Y29	20.3	Yes	No	0	7	8
27	R:R:L282	R:R:Y29	7.03	No	No	0	5	8
28	R:R:F33	R:R:I34	7.54	Yes	No	0	7	5
29	R:R:F33	R:R:I37	7.54	Yes	No	0	7	7
30	R:R:F33	R:R:F74	5.36	Yes	Yes	0	7	8
31	R:R:F33	R:R:P75	13	Yes	No	0	7	9
32	R:R:F33	R:R:I78	3.77	Yes	No	0	7	7
33	R:R:F68	R:R:I37	5.02	No	No	0	7	7
34	R:R:I37	R:R:S71	7.74	No	No	0	7	6
35	R:R:L39	R:R:P292	6.57	No	No	0	8	9
36	R:R:D67	R:R:N40	6.73	Yes	No	1	9	9
37	R:R:N40	R:R:V288	5.91	No	Yes	1	9	8
38	R:R:F296	R:R:S43	5.28	Yes	No	1	7	8
39	R:R:F302	R:R:S43	5.28	Yes	No	1	9	8
40	R:R:W45	R:R:Y49	6.75	No	No	0	4	5
41	R:R:F302	R:R:I46	7.54	Yes	Yes	0	9	7
42	R:R:I46	R:R:L306	7.14	Yes	No	0	7	7
43	R:R:F47	R:R:L60	6.09	Yes	Yes	1	7	8
44	R:R:F47	R:R:K61	6.2	Yes	No	0	7	6
45	R:R:F47	R:R:V64	3.93	Yes	No	1	7	9
46	R:R:F296	R:R:F47	7.5	Yes	Yes	1	7	7
47	R:R:F302	R:R:F47	10.72	Yes	Yes	1	9	7
48	R:R:I305	R:R:V50	4.61	No	No	0	5	5
49	R:R:I58	R:R:S52	4.64	No	No	0	6	6
50	R:R:K61	R:R:S52	6.12	No	No	0	6	6
51	R:R:K122	R:R:K54	5.75	No	No	0	8	8
52	R:R:S55	R:R:Y59	5.09	No	Yes	1	7	7
53	R:R:D118	R:R:S55	8.83	No	No	1	8	7
54	R:R:S138	R:R:S55	4.89	No	No	1	8	7
55	R:R:F56	R:R:L60	12.18	No	Yes	1	8	8
56	R:R:F56	R:R:I115	7.54	No	Yes	1	8	9
57	R:R:F56	R:R:R119	6.41	No	Yes	1	8	9
58	R:R:I58	R:R:K139	8.72	No	No	0	6	5
59	R:R:F111	R:R:Y59	7.22	Yes	Yes	1	8	7
60	R:R:L114	R:R:Y59	9.38	No	Yes	0	7	7
61	R:R:I115	R:R:Y59	4.84	Yes	Yes	1	9	7
62	R:R:D118	R:R:Y59	5.75	No	Yes	1	8	7
63	R:R:S138	R:R:Y59	6.36	No	Yes	1	8	7
64	R:R:L141	R:R:Y59	5.86	No	Yes	1	6	7
65	R:R:F296	R:R:L60	8.53	Yes	Yes	1	7	8
66	R:R:F111	R:R:N62	14.5	Yes	No	1	8	9
67	R:R:N62	R:R:S142	8.94	No	No	1	9	7
68	R:R:N62	R:R:W146	4.52	No	Yes	1	9	9
69	R:R:F111	R:R:I63	3.77	Yes	Yes	1	8	9
70	R:R:F112	R:R:I63	6.28	Yes	Yes	1	9	9
71	R:R:D291	R:R:I63	4.2	Yes	Yes	1	9	9
72	R:R:F296	R:R:I63	5.02	Yes	Yes	1	7	9
73	R:R:F296	R:R:V64	7.87	Yes	No	1	7	9
74	R:R:A66	R:R:N104	4.69	No	Yes	0	8	8
75	R:R:D67	R:R:S108	4.42	Yes	No	0	9	9
76	R:R:D67	R:R:V288	4.38	Yes	Yes	1	9	8
77	R:R:D291	R:R:D67	6.65	Yes	Yes	1	9	9
78	R:R:F68	R:R:L72	4.87	No	No	0	7	4
79	R:R:L100	R:R:V69	4.47	No	No	1	5	7
80	R:R:N104	R:R:V69	11.82	Yes	No	1	8	7
81	R:R:F101	R:R:M70	6.22	Yes	No	0	7	7
82	R:R:M105	R:R:M70	4.33	No	No	0	8	7
83	R:R:F74	R:R:S71	3.96	Yes	No	1	8	6
84	R:R:S71	R:R:V288	4.85	No	Yes	1	6	8
85	R:R:L100	R:R:T73	4.42	No	No	0	5	7
86	R:R:F101	R:R:T73	5.19	Yes	No	0	7	7
87	R:R:F101	R:R:F74	4.29	Yes	Yes	1	7	8
88	R:R:F74	R:R:V288	3.93	Yes	Yes	1	8	8
89	R:R:F76	R:R:F92	12.86	No	No	0	6	3
90	R:R:F76	R:R:S97	5.28	No	No	0	6	5
91	R:R:D81	R:R:K77	13.83	No	Yes	1	5	7
92	R:R:E278	R:R:K77	4.05	No	Yes	1	5	7
93	R:R:G85	R:R:P86	4.06	No	No	0	4	4
94	R:R:P86	R:R:Q88	6.32	No	No	0	4	2
95	R:R:Q88	R:R:W87	4.38	No	No	0	2	9
96	R:R:V167	R:R:W87	4.9	No	No	0	2	9
97	R:R:Q88	R:R:V91	5.73	No	No	0	2	3
98	R:R:I170	R:R:N90	7.08	No	No	0	3	7
99	R:R:R95	R:R:V91	10.46	No	No	0	8	3
100	R:R:L175	R:R:V91	5.96	No	No	0	5	3
101	R:R:F92	R:R:V96	11.8	No	No	0	3	4
102	R:R:S97	R:R:V93	4.85	No	No	0	5	6
103	R:R:C172	R:R:C94	7.28	No	No	0	9	9
104	R:R:I157	R:R:V96	6.14	No	No	0	5	4
105	R:R:L100	R:R:N104	8.24	No	Yes	1	5	8
106	R:R:F101	R:R:Y102	5.16	Yes	Yes	1	7	5
107	R:R:F101	R:R:L281	8.53	Yes	No	1	7	6
108	R:R:Y102	R:R:Y249	4.96	Yes	Yes	1	5	7
109	R:R:K277	R:R:Y102	4.78	Yes	Yes	1	5	5
110	R:R:L281	R:R:Y102	10.55	No	Yes	1	6	5
111	R:R:L150	R:R:V103	4.47	No	No	0	3	6
112	R:R:N104	R:R:W146	4.52	Yes	Yes	1	8	9
113	R:R:M105	R:R:Y106	5.99	No	Yes	0	8	8
114	R:R:F191	R:R:Y106	22.69	Yes	Yes	0	5	8
115	R:R:Y106	R:R:Y249	3.97	Yes	Yes	1	8	7
116	R:R:H250	R:R:Y106	10.89	No	Yes	1	8	8
117	R:R:V107	R:R:W146	15.94	No	Yes	0	7	9
118	R:R:M149	R:R:V107	4.56	No	No	0	8	7
119	R:R:F195	R:R:I109	7.54	Yes	No	1	9	8
120	R:R:F246	R:R:I109	13.82	Yes	No	1	9	8
121	R:R:F111	R:R:S142	6.61	Yes	No	1	8	7
122	R:R:F111	R:R:W146	5.01	Yes	Yes	1	8	9
123	R:R:F112	R:R:F242	5.36	Yes	Yes	1	9	9
124	R:R:F112	R:R:N287	4.83	Yes	Yes	1	9	9
125	R:R:D291	R:R:F112	8.36	Yes	Yes	1	9	9
126	R:R:F112	R:R:Y295	13.41	Yes	Yes	1	9	9
127	R:R:I115	R:R:R119	7.52	Yes	Yes	1	9	9
128	R:R:I115	R:R:Y295	6.04	Yes	Yes	1	9	9
129	R:R:L202	R:R:S116	9.01	No	Yes	1	8	9
130	R:R:F205	R:R:S116	6.61	Yes	Yes	0	8	9
131	R:R:S116	R:R:Y206	13.99	Yes	Yes	1	9	9
132	R:R:F117	R:R:Q133	11.71	No	Yes	0	6	7
133	R:R:F117	R:R:S134	6.61	No	No	0	6	7
134	R:R:F117	R:R:F205	10.72	No	Yes	0	6	8
135	R:R:D118	R:R:S134	8.83	No	No	0	8	7
136	R:R:R119	R:R:Y206	8.23	Yes	Yes	1	9	9
137	R:R:I238	R:R:R119	5.01	No	Yes	1	8	9
138	R:R:R119	R:R:Y295	8.23	Yes	Yes	1	9	9
139	R:R:V124	R:R:Y120	11.36	No	Yes	0	8	8
140	R:R:P126	R:R:Y120	11.13	Yes	Yes	0	7	8
141	R:R:F205	R:R:Y120	12.38	Yes	Yes	0	8	8
142	R:R:Q133	R:R:Y121	24.8	Yes	No	0	7	6
143	R:R:V135	R:R:Y121	5.05	No	No	0	3	6
144	R:R:I123	R:R:I209	4.42	No	No	0	8	8
145	R:R:K212	R:R:V124	4.55	No	No	0	5	8
146	R:R:P126	R:R:W128	9.46	Yes	No	2	7	4
147	R:R:P126	R:R:Q133	4.74	Yes	Yes	2	7	7
148	R:R:Q133	R:R:W128	10.95	Yes	No	2	7	4
149	R:R:I132	R:R:Y137	4.84	No	No	0	3	3
150	R:R:S136	R:R:Y137	6.36	No	No	0	4	3
151	R:R:L141	R:R:S138	4.5	No	No	1	6	8
152	R:R:M147	R:R:V143	4.56	No	No	0	4	3
153	R:R:F191	R:R:M149	6.22	Yes	No	0	5	8
154	R:R:I190	R:R:L152	4.28	No	No	0	5	5
155	R:R:F191	R:R:L152	9.74	Yes	No	0	5	5
156	R:R:P155	R:R:W183	12.16	No	Yes	0	7	2
157	R:R:N156	R:R:W183	4.52	No	Yes	1	5	2
158	R:R:N156	R:R:S187	8.94	No	No	1	5	4
159	R:R:L159	R:R:L179	8.3	No	No	0	5	2
160	R:R:G180	R:R:L159	6.84	No	No	0	3	5
161	R:R:K176	R:R:T160	9.01	Yes	No	0	4	5
162	R:R:E166	R:R:T168	5.64	No	No	3	2	3
163	R:R:E166	R:R:Q169	15.29	No	No	3	2	1
164	R:R:Q169	R:R:T168	8.5	No	No	3	1	3
165	R:R:I170	R:R:L175	4.28	No	No	0	3	5
166	R:R:I173	R:R:K171	4.36	Yes	No	0	4	3
167	R:R:E174	R:R:K171	6.75	No	No	0	5	3
168	R:R:K171	R:R:Y256	4.78	No	Yes	0	3	5
169	R:R:I173	R:R:K176	4.36	Yes	Yes	1	4	4
170	R:R:H184	R:R:I173	6.63	Yes	Yes	1	3	4
171	R:R:I173	R:R:Q260	12.35	Yes	Yes	1	4	3
172	R:R:H184	R:R:K176	10.48	Yes	Yes	1	3	4
173	R:R:R181	R:R:T261	6.47	No	No	0	2	1
174	R:R:A186	R:R:W183	3.89	No	Yes	0	4	2
175	R:R:S187	R:R:W183	8.65	No	Yes	1	4	2
176	R:R:H184	R:R:N188	7.65	Yes	Yes	1	3	4
177	R:R:H184	R:R:Q260	7.42	Yes	Yes	1	3	3
178	R:R:K185	R:R:Y189	14.33	No	Yes	0	3	4
179	R:R:N188	R:R:R253	13.26	Yes	Yes	1	4	6
180	R:R:N188	R:R:T257	14.62	Yes	No	1	4	5
181	R:R:I254	R:R:Y189	4.84	No	Yes	0	5	4
182	R:R:T257	R:R:Y189	3.75	No	Yes	0	5	4
183	R:R:K258	R:R:Y189	8.36	No	Yes	0	3	4
184	R:R:I254	R:R:V192	9.22	No	No	0	5	5
185	R:R:F195	R:R:W196	12.03	Yes	Yes	1	9	4
186	R:R:F195	R:R:F199	5.36	Yes	Yes	1	9	7
187	R:R:F195	R:R:F242	6.43	Yes	Yes	1	9	9
188	R:R:F195	R:R:F246	6.43	Yes	Yes	1	9	9
189	R:R:F195	R:R:H250	33.94	Yes	No	1	9	8
190	R:R:F199	R:R:W196	8.02	Yes	Yes	1	7	4
191	R:R:V247	R:R:W196	4.9	Yes	Yes	1	5	4
192	R:R:F199	R:R:I203	10.05	Yes	No	0	7	4
193	R:R:F199	R:R:F242	5.36	Yes	Yes	1	7	9
194	R:R:F199	R:R:V247	3.93	Yes	Yes	1	7	5
195	R:R:F205	R:R:L201	8.53	Yes	No	0	8	7
196	R:R:L202	R:R:Y206	7.03	No	Yes	1	8	9
197	R:R:F242	R:R:L202	8.53	Yes	No	1	9	8
198	R:R:I235	R:R:Y206	6.04	No	Yes	0	8	9
199	R:R:I238	R:R:Y206	7.25	No	Yes	1	8	9
200	R:R:V239	R:R:Y206	3.79	No	Yes	0	8	9
201	R:R:F214	R:R:T210	6.49	No	No	0	4	5
202	R:R:I235	R:R:T210	4.56	No	No	0	8	5
203	R:R:I213	R:R:S231	9.29	No	No	0	8	8
204	R:R:H217	R:R:S216	4.18	Yes	No	0	4	5
205	R:R:H217	R:R:V227	4.15	Yes	No	0	4	5
206	R:R:H217	R:R:K228	9.17	Yes	No	0	4	6
207	R:R:K219	R:R:S224	6.12	No	No	0	3	4
208	R:R:F236	R:R:S232	3.96	No	No	0	5	6
209	R:R:L298	R:R:N234	10.98	No	No	0	7	8
210	R:R:I238	R:R:Y295	8.46	No	Yes	1	8	9
211	R:R:F240	R:R:V244	7.87	No	No	0	5	6
212	R:R:N287	R:R:V241	4.43	Yes	No	0	9	7
213	R:R:L290	R:R:V241	5.96	No	No	0	7	7
214	R:R:I294	R:R:V241	6.14	No	No	0	8	7
215	R:R:F242	R:R:F246	8.57	Yes	Yes	1	9	9
216	R:R:F243	R:R:V247	20.97	No	Yes	0	7	5
217	R:R:C245	R:R:F246	8.38	No	Yes	1	9	9
218	R:R:C245	R:R:N287	4.72	No	Yes	1	9	9
219	R:R:F246	R:R:S284	5.28	Yes	No	0	9	8
220	R:R:F246	R:R:N287	8.46	Yes	Yes	1	9	9
221	R:R:H250	R:R:Y249	14.16	No	Yes	1	8	7
222	R:R:R253	R:R:Y249	16.46	Yes	Yes	1	6	7
223	R:R:T280	R:R:Y249	8.74	No	Yes	0	7	7
224	R:R:L281	R:R:Y249	10.55	No	Yes	1	6	7
225	R:R:S284	R:R:Y249	3.82	No	Yes	0	8	7
226	R:R:R253	R:R:Y256	6.17	Yes	Yes	1	6	5
227	R:R:R253	R:R:T257	6.47	Yes	No	1	6	5
228	R:R:Q260	R:R:R253	4.67	Yes	Yes	1	3	6
229	R:R:K277	R:R:R253	4.95	Yes	Yes	1	5	6
230	R:R:Q260	R:R:Y256	15.78	Yes	Yes	1	3	5
231	R:R:R274	R:R:Y256	6.17	Yes	Yes	1	3	5
232	R:R:K277	R:R:Y256	20.3	Yes	Yes	1	5	5
233	R:R:K270	R:R:S259	6.12	No	No	0	3	3
234	R:R:E262	R:R:Y265	11.22	No	No	0	1	1
235	R:R:S266	R:R:Y265	16.53	No	No	0	5	1
236	R:R:E278	R:R:K277	6.75	No	Yes	1	5	5
237	R:R:D291	R:R:Y295	6.9	Yes	Yes	1	9	9
238	R:R:F296	R:R:P292	8.67	Yes	No	0	7	9
239	R:R:I294	R:R:Y295	7.25	No	Yes	0	8	9
240	R:R:F296	R:R:F302	4.29	Yes	Yes	1	7	9
241	R:R:F297	R:R:R303	4.28	No	No	0	8	8
242	R:R:C299	R:R:P301	3.77	No	No	0	8	6
243	R:R:Q300	R:R:R303	15.19	No	No	0	5	8
244	R:R:E304	R:R:Q300	7.65	No	No	0	5	5
245	R:R:L306	R:R:L310	8.3	No	No	0	7	6
246	R:R:G83	R:R:S82	3.71	No	No	0	5	4
247	R:R:G36	R:R:V288	3.68	No	Yes	0	8	8
248	R:R:N161	R:R:R95	3.62	No	No	0	4	8
249	R:R:A35	R:R:C289	3.61	No	No	0	5	8
250	R:R:P26	R:R:S82	3.56	No	No	0	5	4
251	R:R:P51	R:R:V50	3.53	No	No	0	6	5
252	R:R:P301	R:R:V50	3.53	No	No	0	6	5
253	R:R:P155	R:R:V154	3.53	No	No	0	7	5
254	R:R:P248	R:R:V247	3.53	No	Yes	0	9	5
255	R:R:I46	R:R:W45	3.52	Yes	No	0	7	4
256	R:R:I251	R:R:W196	3.52	No	Yes	0	5	4
257	R:R:G180	R:R:K176	3.49	No	Yes	0	3	4
258	R:R:E178	R:R:R181	3.49	No	No	0	2	2
259	R:R:A153	R:R:V103	3.39	No	No	0	7	6
260	R:R:I254	R:R:P255	3.39	No	No	0	5	5
261	R:R:E271	R:R:Y275	3.37	No	No	0	2	2
262	R:R:L89	R:R:P86	3.28	No	No	0	7	4
263	R:R:L283	R:R:P248	3.28	No	No	0	7	9
264	R:R:C30	R:R:I78	3.27	No	No	0	4	7
265	R:R:S266	R:R:S269	3.26	No	No	0	5	1
266	R:R:S136	R:R:V135	3.23	No	No	0	4	3
267	R:R:A252	R:R:M276	3.22	No	No	0	5	5
268	R:R:V110	R:R:V145	3.21	No	No	0	6	7
269	R:R:S130	R:R:T129	3.2	No	No	0	5	6
270	R:R:C299	R:R:L60	3.17	No	Yes	0	8	8
271	R:R:C94	R:R:L175	3.17	No	No	0	9	5
272	R:R:I272	R:R:S269	3.1	No	No	0	1	1
273	R:R:R274	R:R:Y275	3.09	Yes	No	0	3	2
274	R:R:I157	R:R:V99	3.07	No	No	0	5	6
275	R:R:I109	R:R:V198	3.07	No	No	0	8	9
276	R:R:I170	R:R:V164	3.07	No	No	0	3	2
277	R:R:K219	R:R:S221	3.06	No	No	0	3	3
278	R:R:K230	R:R:S226	3.06	No	No	0	7	4
279	R:R:F68	R:R:G41	3.01	No	No	0	7	4
280	R:R:L273	R:R:S259	3	No	No	0	4	3
281	R:R:L282	R:R:V32	2.98	No	No	0	5	7
282	R:R:N104	R:R:V103	2.96	Yes	No	0	8	6
283	R:R:I157	R:R:I158	2.94	No	No	0	5	4
284	R:R:I190	R:R:I194	2.94	No	No	0	5	6
285	R:R:I209	R:R:I213	2.94	No	No	0	8	8
286	R:R:I209	R:R:I235	2.94	No	No	0	8	8
287	R:R:I293	R:R:I294	2.94	No	No	0	7	8
288	R:R:I57	R:R:K54	2.91	No	No	0	7	8
289	R:R:I57	R:R:K61	2.91	No	No	0	7	6
290	R:R:Q162	R:R:S177	2.89	No	No	0	5	3
291	R:R:I144	R:R:L141	2.85	No	No	0	2	6
292	R:R:I20	R:R:N17	2.83	Yes	No	0	4	5
293	R:R:A285	R:R:F74	2.77	No	Yes	1	7	8
294	R:R:L79	R:R:L89	2.77	No	No	4	4	7
295	R:R:A285	R:R:F101	2.77	No	Yes	1	7	7
296	R:R:A208	R:R:Y120	2.67	No	Yes	0	4	8
297	R:R:F205	R:R:V204	2.62	Yes	No	0	8	4
298	R:R:S259	R:R:Y265	2.54	No	No	0	3	1
299	R:R:I173	R:R:R181	2.51	Yes	No	0	4	2
300	R:R:F297	R:R:L298	2.44	No	No	0	8	7
301	R:R:I65	R:R:W146	2.35	No	Yes	0	5	9
302	R:R:C289	R:R:G36	1.96	No	No	0	8	8
303	R:R:G113	R:R:S116	1.86	No	Yes	0	7	9
304	R:R:G180	R:R:S177	1.86	No	No	0	3	3
305	R:R:G44	R:R:V64	1.84	No	No	0	7	9
306	R:R:G80	R:R:L79	1.71	No	No	4	5	4
307	R:R:G80	R:R:L89	1.71	No	No	4	5	7
308	R:R:G85	R:R:L84	1.71	No	No	0	4	3
309	R:R:K125	R:R:P126	1.67	No	Yes	0	6	7
310	R:R:L273	R:R:P255	1.64	No	No	0	4	5
311	R:R:S231	R:R:S232	1.63	No	No	0	8	6
312	R:R:S226	R:R:V227	1.62	No	No	0	4	5
313	R:R:V110	R:R:V198	1.6	No	No	0	6	9
314	R:R:S224	R:R:T225	1.6	No	No	0	4	3
315	R:R:A286	R:R:L290	1.58	No	No	0	4	7
316	R:R:P301	R:R:Q300	1.58	No	No	0	6	5
317	R:R:I57	R:R:S53	1.55	No	No	0	7	5
318	R:R:I46	R:R:V42	1.54	Yes	No	0	7	7
319	R:R:K215	R:R:S216	1.53	No	No	0	5	5
320	R:R:C267	R:R:Q268	1.53	No	No	0	8	2
321	R:R:M31	R:R:V27	1.52	No	No	0	5	5
322	R:R:I203	R:R:T207	1.52	No	No	0	4	4
323	R:R:M276	R:R:T280	1.51	No	No	0	5	7
324	R:R:K229	R:R:T225	1.5	No	No	0	5	3
325	R:R:L38	R:R:V42	1.49	No	No	0	4	7
326	R:R:N223	R:R:S226	1.49	No	No	0	1	4
327	R:R:I20	R:R:I24	1.47	Yes	No	0	4	6
328	R:R:I46	R:R:K309	1.45	Yes	No	0	7	4
329	R:R:I213	R:R:K228	1.45	No	No	0	8	6
330	R:R:Q162	R:R:S163	1.44	No	No	0	5	2
331	R:R:E166	R:R:V167	1.43	No	No	0	2	2
332	R:R:I197	R:R:L201	1.43	No	No	0	6	7
333	R:R:H217	R:R:S224	1.39	Yes	No	0	4	4
334	R:R:C307	R:R:R303	1.39	No	No	0	4	8
335	R:R:L18	R:R:L19	1.38	No	No	0	3	3
336	R:R:L19	R:R:Q23	1.33	No	No	0	3	3
337	R:R:R222	R:R:S221	1.32	No	No	0	2	3
338	R:R:K230	R:R:R233	1.24	No	No	0	7	5
339	R:R:E262	R:R:H264	1.23	No	No	0	1	1
340	R:R:L140	R:R:Y137	1.17	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.14941	17	1	0
2	R:R:I20	3.47	4	0	4
3	R:R:F33	7.442	5	0	7
4	R:R:I46	4.238	5	0	7
5	R:R:F47	6.888	5	1	7
6	R:R:Y59	6.35714	7	1	7
7	R:R:L60	7.4925	4	1	8
8	R:R:I63	4.8175	4	1	9
9	R:R:D67	5.545	4	1	9
10	R:R:F74	4.062	5	1	8
11	R:R:K77	11.36	4	1	7
12	R:R:F101	5.36	6	1	7
13	R:R:Y102	9.696	5	1	5
14	R:R:N104	6.446	5	1	8
15	R:R:Y106	10.885	4	1	8
16	R:R:F111	7.422	5	1	8
17	R:R:F112	7.648	5	1	9
18	R:R:I115	6.485	4	1	9
19	R:R:S116	7.8675	4	1	9
20	R:R:R119	7.08	5	1	9
21	R:R:Y120	9.385	4	0	8
22	R:R:P126	6.75	4	2	7
23	R:R:Q133	13.05	4	2	7
24	R:R:W146	6.468	5	1	9
25	R:R:I173	6.042	5	1	4
26	R:R:K176	6.26	5	1	4
27	R:R:W183	7.305	4	1	2
28	R:R:H184	7.76	5	1	3
29	R:R:N188	10.3275	4	1	4
30	R:R:Y189	7.82	4	0	4
31	R:R:F191	10.945	4	0	5
32	R:R:F195	11.955	6	1	9
33	R:R:W196	7.1175	4	1	4
34	R:R:F199	6.544	5	1	7
35	R:R:F205	8.172	5	0	8
36	R:R:Y206	7.72167	6	1	9
37	R:R:H217	4.7225	4	0	4
38	R:R:F242	6.85	5	1	9
39	R:R:F246	8.49	6	1	9
40	R:R:V247	8.3325	4	1	5
41	R:R:Y249	8.95143	7	1	7
42	R:R:R253	8.15571	7	1	6
43	R:R:Y256	9.69	6	1	5
44	R:R:Q260	9.538	5	1	3
45	R:R:R274	6.0625	4	1	3
46	R:R:K277	8.808	5	1	5
47	R:R:N287	5.61	4	1	9
48	R:R:V288	4.55	5	1	8
49	R:R:D291	6.5275	4	1	9
50	R:R:Y295	8.38167	6	1	9
51	R:R:F296	6.73714	7	1	7
52	R:R:F302	6.9575	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R274	29.7471	8.52	Yes	Yes	1	0	3
2	R:R:R274	R:R:T21	30.1017	6.47	Yes	No	0	3	4
3	R:R:I20	R:R:T21	27.4208	4.56	Yes	No	0	4	4
4	R:R:I20	R:R:N17	15.3684	2.83	Yes	No	0	4	5
5	R:R:L19	R:R:N17	12.3096	8.24	No	No	0	3	5
6	L:L:?1	R:R:K77	11.5185	7.26	Yes	Yes	1	0	7
7	L:L:?1	R:R:Y102	58.1109	23.03	Yes	Yes	1	0	5
8	R:R:F101	R:R:Y102	25.7374	5.16	Yes	Yes	1	7	5
9	R:R:F101	R:R:F74	22.4253	4.29	Yes	Yes	1	7	8
10	R:R:F33	R:R:F74	13.272	5.36	Yes	Yes	0	7	8
11	L:L:?1	R:R:F191	48.716	5.13	Yes	Yes	0	0	5
12	R:R:F191	R:R:M149	27.9391	6.22	Yes	No	0	5	8
13	R:R:M149	R:R:V107	27.565	4.56	No	No	0	8	7
14	R:R:V107	R:R:W146	27.5572	15.94	No	Yes	0	7	9
15	R:R:F111	R:R:W146	28.8002	5.01	Yes	Yes	1	8	9
16	R:R:F111	R:R:I63	22.7058	3.77	Yes	Yes	1	8	9
17	R:R:F296	R:R:I63	42.1658	5.02	Yes	Yes	1	7	9
18	R:R:F74	R:R:V288	14.2033	3.93	Yes	Yes	1	8	8
19	R:R:D67	R:R:V288	18.5715	4.38	Yes	Yes	1	9	8
20	R:R:F296	R:R:F302	13.0421	4.29	Yes	Yes	1	7	9
21	R:R:F302	R:R:I46	13.7123	7.54	Yes	Yes	0	9	7
22	R:R:F296	R:R:F47	10.4002	7.5	Yes	Yes	1	7	7
23	R:R:F296	R:R:L60	16.8803	8.53	Yes	Yes	1	7	8
24	R:R:F47	R:R:K61	12.4031	6.2	Yes	No	0	7	6
25	R:R:C299	R:R:L60	18.0376	3.17	No	Yes	0	8	8
26	R:R:C299	R:R:P301	16.6037	3.77	No	No	0	8	6
27	R:R:F111	R:R:Y59	15.6802	7.22	Yes	Yes	1	8	7
28	R:R:Y102	R:R:Y249	48.5641	4.96	Yes	Yes	1	5	7
29	R:R:H250	R:R:Y249	63.4766	14.16	No	Yes	1	8	7
30	R:R:F195	R:R:H250	85.5707	33.94	Yes	No	1	9	8
31	R:R:F195	R:R:F242	68.3163	6.43	Yes	Yes	1	9	9
32	R:R:F112	R:R:F242	30.4368	5.36	Yes	Yes	1	9	9
33	L:L:?1	R:R:R253	48.4589	5.11	Yes	Yes	1	0	6
34	R:R:R253	R:R:Y249	83.5015	16.46	Yes	Yes	1	6	7
35	R:R:F191	R:R:Y106	22.8968	22.69	Yes	Yes	0	5	8
36	R:R:H250	R:R:Y106	22.8227	10.89	No	Yes	1	8	8
37	R:R:S284	R:R:Y249	67.042	3.82	No	Yes	0	8	7
38	R:R:F246	R:R:S284	66.8862	5.28	Yes	No	0	9	8
39	R:R:F242	R:R:F246	51.3424	8.57	Yes	Yes	1	9	9
40	R:R:F246	R:R:N287	16.3738	8.46	Yes	Yes	1	9	9
41	R:R:F112	R:R:N287	12.8707	4.83	Yes	Yes	1	9	9
42	R:R:D291	R:R:D67	19.8535	6.65	Yes	Yes	1	9	9
43	L:L:?1	R:R:V99	18.7235	7.67	Yes	No	0	0	6
44	R:R:I157	R:R:V99	16.5803	3.07	No	No	0	5	6
45	R:R:I157	R:R:V96	11.8809	6.14	No	No	0	5	4
46	L:L:?1	R:R:C172	48.5056	9.65	Yes	No	0	0	9
47	R:R:C172	R:R:C94	46.3664	7.28	No	No	0	9	9
48	R:R:C94	R:R:L175	44.1219	3.17	No	No	0	9	5
49	R:R:L175	R:R:V91	35.066	5.96	No	No	0	5	3
50	R:R:Q88	R:R:V91	28.1923	5.73	No	No	0	2	3
51	R:R:P86	R:R:Q88	14.2345	6.32	No	No	0	4	2
52	R:R:Q88	R:R:W87	11.8809	4.38	No	No	0	2	9
53	R:R:D291	R:R:Y295	11.7757	6.9	Yes	Yes	1	9	9
54	R:R:F112	R:R:Y295	11.7562	13.41	Yes	Yes	1	9	9
55	R:R:F242	R:R:L202	100	8.53	Yes	No	1	9	8
56	R:R:L202	R:R:S116	44.9363	9.01	No	Yes	1	8	9
57	R:R:F205	R:R:S116	49.9123	6.61	Yes	Yes	0	8	9
58	R:R:L202	R:R:Y206	53.2167	7.03	No	Yes	1	8	9
59	R:R:F117	R:R:F205	22.5656	10.72	No	Yes	0	6	8
60	R:R:F117	R:R:Q133	25.3673	11.71	No	Yes	0	6	7
61	R:R:F205	R:R:Y120	18.2792	12.38	Yes	Yes	0	8	8
62	R:R:Q133	R:R:Y121	19.0975	24.8	Yes	No	0	7	6
63	R:R:V135	R:R:Y121	15.8945	5.05	No	No	0	3	6
64	R:R:I235	R:R:Y206	60.5697	6.04	No	Yes	0	8	9
65	R:R:I209	R:R:I235	53.1271	2.94	No	No	0	8	8
66	R:R:S136	R:R:V135	12.9486	3.23	No	No	0	4	3
67	L:L:?1	R:R:N156	13.9578	14.77	Yes	No	1	0	5
68	L:L:?1	R:R:K176	20.7419	3.96	Yes	Yes	1	0	4
69	R:R:G180	R:R:K176	14.4917	3.49	No	Yes	0	3	4
70	R:R:T257	R:R:Y189	39.29	3.75	No	Yes	0	5	4
71	R:R:R253	R:R:T257	33.1995	6.47	Yes	No	1	6	5
72	R:R:I254	R:R:Y189	31.4811	4.84	No	Yes	0	5	4
73	R:R:I209	R:R:I213	48.1432	2.94	No	No	0	8	8
74	R:R:I213	R:R:K228	38.5964	1.45	No	No	0	8	6
75	R:R:H217	R:R:K228	36.3286	9.17	Yes	No	0	4	6
76	R:R:H217	R:R:V227	13.1473	4.15	Yes	No	0	4	5
77	R:R:H217	R:R:S224	15.7542	1.39	Yes	No	0	4	4
78	R:R:P301	R:R:Q300	10.6184	1.58	No	No	0	6	5
79	R:R:I254	R:R:P255	26.2362	3.39	No	No	0	5	5
80	R:R:L273	R:R:P255	23.5982	1.64	No	No	0	4	5
81	R:R:L273	R:R:S259	21.1628	3	No	No	0	4	3
82	R:R:S259	R:R:Y265	15.8555	2.54	No	No	0	3	1
83	R:R:I109	R:R:V198	10.7275	3.07	No	No	0	8	9
84	R:R:S226	R:R:V227	10.5327	1.62	No	No	0	4	5
85	R:R:R119	R:R:Y206	18.2909	8.23	Yes	Yes	1	9	9
86	R:R:F112	R:R:I63	25.453	6.28	Yes	Yes	1	9	9
87	R:R:R253	R:R:Y256	11.9004	6.17	Yes	Yes	1	6	5
88	R:R:S116	R:R:Y206	10.2482	13.99	Yes	Yes	1	9	9
89	R:R:F56	R:R:L60	10.9613	12.18	No	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:K77	7.26	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:D81	8.89	1	Yes	No	0	5	0	1
L:L:?1	R:R:A98	4.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:V99	7.67	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y102	23.03	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N156	14.77	1	Yes	No	0	5	0	1
L:L:?1	R:R:C172	9.65	1	Yes	No	0	9	0	1
L:L:?1	R:R:K176	3.96	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:H184	6.62	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:N188	5.78	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F191	5.13	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R253	5.11	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y256	4.94	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Q260	7.47	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:R274	8.52	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:K277	7.26	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:E278	8.06	1	Yes	No	0	5	0	1
R:R:R274	R:R:T21	6.47	1	Yes	No	3	4	1	2
R:R:D81	R:R:P26	6.44	1	No	No	5	5	1	2
R:R:K77	R:R:Y29	20.3	1	Yes	No	7	8	1	2
R:R:D81	R:R:K77	13.83	1	No	Yes	5	7	1	1
R:R:E278	R:R:K77	4.05	1	No	Yes	5	7	1	1
R:R:C172	R:R:C94	7.28	0	No	No	9	9	1	2
R:R:F101	R:R:Y102	5.16	1	Yes	Yes	7	5	2	1
R:R:F101	R:R:L281	8.53	1	Yes	No	7	6	2	2
R:R:Y102	R:R:Y249	4.96	1	Yes	Yes	5	7	1	2
R:R:K277	R:R:Y102	4.78	1	Yes	Yes	5	5	1	1
R:R:L281	R:R:Y102	10.55	1	No	Yes	6	5	2	1
R:R:F191	R:R:Y106	22.69	0	Yes	Yes	5	8	1	2
R:R:Y106	R:R:Y249	3.97	1	Yes	Yes	8	7	2	2
R:R:F191	R:R:M149	6.22	0	Yes	No	5	8	1	2
R:R:F191	R:R:L152	9.74	0	Yes	No	5	5	1	2
R:R:N156	R:R:W183	4.52	1	No	Yes	5	2	1	2
R:R:N156	R:R:S187	8.94	1	No	No	5	4	1	2
R:R:K176	R:R:T160	9.01	1	Yes	No	4	5	1	2
R:R:I173	R:R:K171	4.36	1	Yes	No	4	3	2	2
R:R:K171	R:R:Y256	4.78	0	No	Yes	3	5	2	1
R:R:I173	R:R:K176	4.36	1	Yes	Yes	4	4	2	1
R:R:H184	R:R:I173	6.63	1	Yes	Yes	3	4	1	2
R:R:I173	R:R:Q260	12.35	1	Yes	Yes	4	3	2	1
R:R:H184	R:R:K176	10.48	1	Yes	Yes	3	4	1	1
R:R:S187	R:R:W183	8.65	1	No	Yes	4	2	2	2
R:R:H184	R:R:N188	7.65	1	Yes	Yes	3	4	1	1
R:R:H184	R:R:Q260	7.42	1	Yes	Yes	3	3	1	1
R:R:N188	R:R:R253	13.26	1	Yes	Yes	4	6	1	1
R:R:N188	R:R:T257	14.62	1	Yes	No	4	5	1	2
R:R:R253	R:R:Y249	16.46	1	Yes	Yes	6	7	1	2
R:R:L281	R:R:Y249	10.55	1	No	Yes	6	7	2	2
R:R:R253	R:R:Y256	6.17	1	Yes	Yes	6	5	1	1
R:R:R253	R:R:T257	6.47	1	Yes	No	6	5	1	2
R:R:Q260	R:R:R253	4.67	1	Yes	Yes	3	6	1	1
R:R:K277	R:R:R253	4.95	1	Yes	Yes	5	6	1	1
R:R:Q260	R:R:Y256	15.78	1	Yes	Yes	3	5	1	1
R:R:R274	R:R:Y256	6.17	1	Yes	Yes	3	5	1	1
R:R:K277	R:R:Y256	20.3	1	Yes	Yes	5	5	1	1
R:R:E278	R:R:K277	6.75	1	No	Yes	5	5	1	1
R:R:G180	R:R:K176	3.49	0	No	Yes	3	4	2	1
R:R:R274	R:R:Y275	3.09	1	Yes	No	3	2	1	2
R:R:I157	R:R:V99	3.07	0	No	No	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9J0F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.75
Number of Linked Nodes	280
Number of Links	340
Number of Hubs	52
Number of Links mediated by Hubs	191
Number of Communities	4
Number of Nodes involved in Communities	76
Number of Links involved in Communities	128

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	80244
Length Of Smallest Path	3
Average Path Length	12.2459
Length of Longest Path	26
Minimum Path Strength	1.355
Average Path Strength	7.69852
Maximum Path Strength	24.05
Minimum Path Correlation	0.7
Average Path Correlation	0.92755
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	52.7545
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.645
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled UDP receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled pyrimidinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • multicellular organismal-level homeostasis • homeostatic process • hematopoietic stem cell homeostasis • homeostasis of number of cells
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NAI
Name	NADH
Synonyms	Nicotinamide-adenine dinucleotide, reduced
Identifier
Formula	C21 H29 N7 O14 P2
Molecular Weight	665.441
SMILES
PubChem	439153
Formal Charge	0
Total Atoms	73
Total Chiral Atoms	10
Total Bonds	77
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q15391
Sequence	>9J0F_nogp_Chain_R N L L I T Q Q I I P V L Y C M V F I A G I L L N G V S G W I F F Y V P S S K S F I I Y L K N I V I A D F V M S L T F P F K I L G D S G L G P W Q L N V F V C R V S A V L F Y V N M Y V S I V F F G L I S F D R Y Y K I V K P L W T S F I Q S V S Y S K L L S V I V W M L M L L L A V P N I I L T N Q S V R E V T Q I K C I E L K S E L G R K W H K A S N Y I F V A I F W I V F L L L I V F Y T A I T K K I F K S H L K S S R N S T S V K K K S S R N I F S I V F V F F V C F V P Y H I A R I P Y T K S Q T E A H Y S C Q S K E I L R Y M K E F T L L L S A A N V C L D P I I Y F F L C Q P F R E I L C K K L H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9J0F	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	NADH	-	Gi1/β1/γ2	2.76	2025-06-04	doi.org/10.1038/s41421-025-00799-9
	9J0F (No Gprot)	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	NADH	-		2.76	2025-06-04	doi.org/10.1038/s41421-025-00799-9
	9J0I	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	UDP-Glucuronic acid	-	Gi1/β1/γ2	2.76	2025-06-04	doi.org/10.1038/s41421-025-00799-9
	9J0I (No Gprot)	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	UDP-Glucuronic acid	-		2.76	2025-06-04	doi.org/10.1038/s41421-025-00799-9
	9J05	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	-	-	-	3.2	2025-08-06	To be published

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