Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 8.721181710
2R:R:Y29 5.625408
3R:R:F33 6.6407
4R:R:N40 5.185449
5R:R:F47 7.12627
6R:R:Y59 7.808527
7R:R:L60 7.49428
8R:R:I63 5.1325409
9R:R:D67 6.22449
10R:R:F74 6.165418
11R:R:R95 4.4225408
12R:R:F101 5.83167617
13R:R:Y102 9.544515
14R:R:I109 6.735438
15R:R:F111 7.67833628
16R:R:F112 9.6875409
17R:R:I115 6.4975429
18R:R:S116 6.435429
19R:R:Y120 9.60667658
20R:R:P126 8.1375457
21R:R:W146 9.6275429
22R:R:M149 4.5425408
23R:R:N156 5.25415
24R:R:L159 3.1525405
25R:R:Y189 5.7525404
26R:R:F191 11.38405
27R:R:F195 14.406539
28R:R:F199 6.8575407
29R:R:F205 8.51508
30R:R:Y206 5.86572729
31R:R:I209 2.68408
32R:R:K219 8.8175403
33R:R:F242 6.3439
34R:R:F246 7.82833639
35R:R:Y249 7.72667617
36R:R:R253 8.77167616
37R:R:Y256 9.66615
38R:R:Y275 9.782512
39R:R:K277 9.7975415
40R:R:L281 5.9425416
41R:R:F296 5.96167627
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:R274 15.81734.79YesNo103
2R:R:R274 R:R:T21 15.89245.17NoNo134
3R:R:T21 R:R:Y275 11.47623.75NoYes142
4L:L:?1 R:R:K77 24.999113.91YesNo007
5R:R:D81 R:R:K77 22.220112.44NoNo057
6R:R:D81 R:R:P26 20.23734.83NoNo055
7R:R:P26 R:R:S82 18.2473.56NoNo054
8L:L:?1 R:R:Y102 31.439426.59YesYes105
9R:R:L281 R:R:Y29 12.97463.52YesYes068
10R:R:F101 R:R:Y102 15.43056.19YesYes175
11R:R:F101 R:R:F74 10.53366.43YesYes178
12R:R:F33 R:R:F74 13.19995.36YesYes078
13R:R:F33 R:R:I37 12.689212.56YesNo077
14R:R:I37 R:R:S71 12.85446.19NoNo076
15R:R:Y102 R:R:Y249 22.07744.96YesYes157
16R:R:S284 R:R:Y249 42.85183.82NoYes087
17R:R:F246 R:R:S284 42.59645.28YesNo098
18R:R:F246 R:R:N287 42.427412.08YesNo399
19R:R:D291 R:R:N287 42.919412.12NoNo099
20R:R:D291 R:R:D67 17.36086.65NoYes099
21L:L:?1 R:R:R253 17.56368.99YesYes106
22R:R:R253 R:R:Y249 31.383111.32YesYes167
23L:L:?1 R:R:F191 1006.01YesYes005
24R:R:F191 R:R:M149 97.6686.22YesYes058
25R:R:M149 R:R:V107 51.32374.56YesNo087
26R:R:V107 R:R:W146 51.237422.07NoYes079
27R:R:F111 R:R:W146 47.79755.01YesYes289
28R:R:F111 R:R:I63 40.48223.77YesYes089
29R:R:D67 R:R:I63 19.80924.2YesYes099
30R:R:M149 R:R:V110 47.18164.56YesNo086
31R:R:V110 R:R:V145 47.15166.41NoNo067
32R:R:F111 R:R:V145 47.17797.87YesNo087
33R:R:N40 R:R:S71 13.0765.96YesNo096
34R:R:D67 R:R:V288 11.80297.3YesNo498
35R:R:F296 R:R:I63 37.48175.02YesYes079
36R:R:F296 R:R:F47 18.23584.29YesYes277
37R:R:F47 R:R:V50 11.45749.18YesNo075
38R:R:F296 R:R:L60 12.55776.09YesYes278
39R:R:F111 R:R:Y59 54.48957.22YesYes287
40R:R:I115 R:R:Y59 50.66664.84YesYes297
41R:R:I115 R:R:R119 42.28857.52YesNo299
42R:R:R119 R:R:Y206 48.45478.23NoYes299
43R:R:I209 R:R:Y206 50.79432.42YesYes089
44R:R:D291 R:R:F112 36.640510.75NoYes099
45R:R:F112 R:R:I63 19.9827.54YesYes099
46R:R:L84 R:R:S82 10.21073NoNo034
47L:L:?1 R:R:N90 13.92094.74YesNo007
48R:R:I170 R:R:N90 12.073314.16NoNo037
49L:L:?1 R:R:V99 15.38175.14YesNo006
50L:L:?1 R:R:K176 11.46126.26YesNo004
51R:R:H250 R:R:Y249 20.244814.16NoYes087
52R:R:F195 R:R:H250 26.493739.6YesNo098
53R:R:F195 R:R:F242 10.48117.5YesYes399
54R:R:F242 R:R:F246 13.75197.5YesYes399
55R:R:F112 R:R:Y295 42.476216.5YesNo099
56R:R:S116 R:R:Y206 14.6875.09YesYes299
57R:R:F205 R:R:S116 11.81427.93YesYes089
58R:R:I209 R:R:Y120 20.46642.42YesYes088
59R:R:P126 R:R:Y120 14.277712.52YesYes578
60R:R:P126 R:R:T129 11.13453.5YesNo076
61L:L:?1 R:R:N156 31.65355.42YesYes105
62R:R:N156 R:R:W183 28.07094.52YesNo052
63R:R:P155 R:R:W183 26.114412.16NoNo072
64R:R:P155 R:R:V154 16.21923.53NoNo075
65R:R:L150 R:R:V154 14.21765.96NoNo035
66R:R:L150 R:R:M147 12.20852.83NoNo034
67R:R:M147 R:R:V143 10.19191.52NoNo043
68L:L:?1 R:R:N188 20.06086.09YesNo104
69R:R:N188 R:R:T257 28.82577.31NoNo045
70R:R:T257 R:R:Y189 27.19976.24NoYes054
71R:R:F195 R:R:W196 13.004612.03YesNo094
72R:R:F199 R:R:F242 21.63436.43YesYes079
73R:R:F199 R:R:V247 23.29423.93YesNo075
74R:R:I238 R:R:Y295 46.26547.25NoNo089
75R:R:I209 R:R:I213 24.71742.94YesNo088
76R:R:I213 R:R:K228 18.99061.45NoNo086
77R:R:K219 R:R:K228 17.634920.11YesNo036
78R:R:K219 R:R:S224 11.3266.12YesNo034
79R:R:I238 R:R:I294 22.4982.94NoNo088
80R:R:I294 R:R:S237 14.11241.55NoNo086
81R:R:R233 R:R:S237 11.30351.32NoNo056
82R:R:F243 R:R:V247 15.558214.42NoNo075
83R:R:F243 R:R:V244 11.6791.31NoNo076
84R:R:K258 R:R:Y189 12.80562.39NoYes034
85R:R:K258 R:R:Y265 10.9739.55NoNo031
86R:R:C299 R:R:L60 12.60663.17NoYes088
87R:R:C299 R:R:P301 11.08945.65NoNo086
88R:R:C289 R:R:V288 11.73161.71NoNo088
89R:R:N188 R:R:R253 10.428516.87NoYes146
90R:R:I238 R:R:Y206 26.23466.04NoYes089
91R:R:L281 R:R:Y249 12.08835.86YesYes167
92R:R:D67 R:R:N40 12.43016.73YesYes499
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:K77 13.91 1 Yes No 0 7 0 1
L:L:?1 R:R:N90 4.74 1 Yes No 0 7 0 1
L:L:?1 R:R:V93 4.41 1 Yes No 0 6 0 1
L:L:?1 R:R:A98 3.88 1 Yes No 0 6 0 1
L:L:?1 R:R:V99 5.14 1 Yes No 0 6 0 1
L:L:?1 R:R:Y102 26.59 1 Yes Yes 0 5 0 1
L:L:?1 R:R:N156 5.42 1 Yes Yes 0 5 0 1
L:L:?1 R:R:C172 11.74 1 Yes No 0 9 0 1
L:L:?1 R:R:K176 6.26 1 Yes No 0 4 0 1
L:L:?1 R:R:H184 16.48 1 Yes No 0 3 0 1
L:L:?1 R:R:N188 6.09 1 Yes No 0 4 0 1
L:L:?1 R:R:F191 6.01 1 Yes Yes 0 5 0 1
L:L:?1 R:R:R253 8.99 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y256 6.94 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Q260 8.53 1 Yes No 0 3 0 1
L:L:?1 R:R:R274 4.79 1 Yes No 0 3 0 1
L:L:?1 R:R:K277 8.34 1 Yes Yes 0 5 0 1
R:R:R274 R:R:T21 5.17 1 No No 3 4 1 2
R:R:D81 R:R:K77 12.44 0 No No 5 7 2 1
R:R:E278 R:R:K77 5.4 0 No No 5 7 2 1
R:R:I170 R:R:N90 14.16 0 No No 3 7 2 1
R:R:S97 R:R:V93 6.46 0 No No 5 6 2 1
R:R:C172 R:R:C94 5.46 0 No No 9 9 1 2
R:R:I157 R:R:V99 7.68 0 No No 5 6 2 1
R:R:F101 R:R:Y102 6.19 1 Yes Yes 7 5 2 1
R:R:F101 R:R:L281 8.53 1 Yes Yes 7 6 2 2
R:R:Y102 R:R:Y249 4.96 1 Yes Yes 5 7 1 2
R:R:R253 R:R:Y102 4.12 1 Yes Yes 6 5 1 1
R:R:L281 R:R:Y102 5.86 1 Yes Yes 6 5 2 1
R:R:F191 R:R:Y106 24.76 0 Yes No 5 8 1 2
R:R:F191 R:R:M149 6.22 0 Yes Yes 5 8 1 2
R:R:F191 R:R:L152 8.53 0 Yes No 5 5 1 2
R:R:N156 R:R:W183 4.52 1 Yes No 5 2 1 2
R:R:H184 R:R:N156 5.1 1 No Yes 3 5 1 1
R:R:N156 R:R:S187 5.96 1 Yes No 5 4 1 2
R:R:K176 R:R:T160 12.01 0 No No 4 5 1 2
R:R:I173 R:R:Q260 6.86 0 No No 4 3 2 1
R:R:H184 R:R:S187 4.18 1 No No 3 4 1 2
R:R:N188 R:R:R253 16.87 1 No Yes 4 6 1 1
R:R:N188 R:R:T257 7.31 1 No No 4 5 1 2
R:R:R253 R:R:Y249 11.32 1 Yes Yes 6 7 1 2
R:R:L281 R:R:Y249 5.86 1 Yes Yes 6 7 2 2
R:R:R253 R:R:Y256 5.14 1 Yes Yes 6 5 1 1
R:R:K277 R:R:R253 6.19 1 Yes Yes 5 6 1 1
R:R:S259 R:R:Y256 5.09 0 No Yes 3 5 2 1
R:R:Q260 R:R:Y256 14.65 1 No Yes 3 5 1 1
R:R:R274 R:R:Y256 8.23 1 No Yes 3 5 1 1
R:R:K277 R:R:Y256 17.91 1 Yes Yes 5 5 1 1
R:R:E278 R:R:K277 6.75 0 No Yes 5 5 2 1
R:R:A153 R:R:V99 1.7 0 No No 7 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9J0I_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.71
Number of Linked Nodes 277
Number of Links 318
Number of Hubs 41
Number of Links mediated by Hubs 159
Number of Communities 5
Number of Nodes involved in Communities 50
Number of Links involved in Communities 73
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 70516
Length Of Smallest Path 3
Average Path Length 12.6064
Length of Longest Path 28
Minimum Path Strength 1.12
Average Path Strength 7.53559
Maximum Path Strength 26.88
Minimum Path Correlation 0.7
Average Path Correlation 0.929777
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 52.4815
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.1664
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeUGA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeUGA
NameUDP-alpha-D-glucuronic acid
Synonymsuridine diphosphate glucuronic acid
Identifier
FormulaC15 H22 N2 O18 P2
Molecular Weight580.285
SMILES
PubChem17473
Formal Charge0
Total Atoms59
Total Chiral Atoms11
Total Bonds61
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ15391
Sequence
>9J0I_nogp_Chain_R
SQNLLITQQ IIPVLYCMV FIAGILLNG VSGWIFFYV PSSKSFIIY 
LKNIVIADF VMSLTFPFK ILGDSGLGP WQLNVFVCR VSAVLFYVN 
MYVSIVFFG LISFDRYYK IVKPLWTSF IQSVSYSKL LSVIVWMLM 
LLLAVPNII LTNQSVREV TQIKCIELK SELGRKWHK ASNYIFVAI 
FWIVFLLLI VFYTAITKK IFKSHLKSS RNSTSVKKK SSRNIFSIV 
FVFFVCFVP YHIARIPYT KSQTEAHYS CQSKEILRY MKEFTLLLS 
AANVCLDPI IYFFLCQPF REILCKKLH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9J0FANucleotideP2YP2Y14Homo sapiensNADH-Gi1/β1/γ22.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J0F (No Gprot) ANucleotideP2YP2Y14Homo sapiensNADH-2.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J0IANucleotideP2YP2Y14Homo sapiensUDP-Glucuronic acid-Gi1/β1/γ22.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J0I (No Gprot) ANucleotideP2YP2Y14Homo sapiensUDP-Glucuronic acid-2.762025-06-04doi.org/10.1038/s41421-025-00799-9
9J05ANucleotideP2YP2Y14Homo sapiens---3.22025-08-06To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9J0I_nogp.zip



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