CodeUPG
NameUridine diphosphate glucose
SynonymsUridine diphosphate glucose
Identifier
FormulaC15 H24 N2 O17 P2
Molecular Weight566.302
SMILES
PubChem8629
Formal Charge0
Total Atoms60
Total Chiral Atoms9
Total Bonds62
Total Aromatic Bonds0
Networks4
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This ligand is also present in the following 4 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9J0B A Nucleotide P2Y P2Y14 Homo Sapiens UDP-Glucose - Gi1/Beta1/Gamma2 2.88 2025-06-04 10.1038/s41421-025-00799-9

A 2D representation of the interactions of UPG in 9J0B
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:C94 8.02 3 Yes No 0 9 0 1
L:L:?1 R:R:V99 5.27 3 Yes No 0 6 0 1
L:L:?1 R:R:Y102 24.28 3 Yes Yes 0 5 0 1
L:L:?1 R:R:N156 13.18 3 Yes No 0 5 0 1
L:L:?1 R:R:K176 5.7 3 Yes No 0 4 0 1
L:L:?1 R:R:H184 14.94 3 Yes No 0 3 0 1
L:L:?1 R:R:N188 6.24 3 Yes No 0 4 0 1
L:L:?1 R:R:F191 4.92 3 Yes Yes 0 5 0 1
L:L:?1 R:R:R253 9.21 3 Yes Yes 0 6 0 1
L:L:?1 R:R:Y256 4.74 3 Yes Yes 0 5 0 1
L:L:?1 R:R:Q260 8.74 3 Yes No 0 3 0 1
L:L:?1 R:R:R274 3.68 3 Yes Yes 0 3 0 1
L:L:?1 R:R:K277 7.12 3 Yes Yes 0 5 0 1
L:L:?1 R:R:E278 8.03 3 Yes No 0 5 0 1
R:R:R274 R:R:T21 11.64 3 Yes No 3 4 1 2
R:R:T21 R:R:Y275 3.75 3 No Yes 4 2 2 2
R:R:E278 R:R:K77 4.05 3 No No 5 7 1 2
R:R:C172 R:R:C94 7.28 0 No No 9 9 2 1
R:R:I157 R:R:V99 7.68 0 No No 5 6 2 1
R:R:F101 R:R:Y102 5.16 3 Yes Yes 7 5 2 1
R:R:F101 R:R:L281 7.31 3 Yes No 7 6 2 2
R:R:Y102 R:R:Y249 6.95 3 Yes Yes 5 7 1 2
R:R:L281 R:R:Y102 8.21 3 No Yes 6 5 2 1
R:R:F191 R:R:Y106 23.73 0 Yes No 5 8 1 2
R:R:F191 R:R:L152 9.74 0 Yes No 5 5 1 2
R:R:N156 R:R:S187 5.96 0 No No 5 4 1 2
R:R:K176 R:R:T160 6.01 3 No No 4 5 1 2
R:R:H184 R:R:I173 3.98 3 No Yes 3 4 1 2
R:R:I173 R:R:Q260 5.49 0 Yes No 4 3 2 1
R:R:H184 R:R:K176 5.24 3 No No 3 4 1 1
R:R:N188 R:R:R253 19.28 3 No Yes 4 6 1 1
R:R:N188 R:R:T257 13.16 3 No No 4 5 1 2
R:R:R253 R:R:Y249 13.38 3 Yes Yes 6 7 1 2
R:R:L281 R:R:Y249 10.55 3 No Yes 6 7 2 2
R:R:R253 R:R:T257 7.76 3 Yes No 6 5 1 2
R:R:K277 R:R:R253 4.95 3 Yes Yes 5 6 1 1
R:R:Q260 R:R:Y256 16.91 3 No Yes 3 5 1 1
R:R:R274 R:R:Y256 7.2 3 Yes Yes 3 5 1 1
R:R:K277 R:R:Y256 14.33 3 Yes Yes 5 5 1 1
R:R:E271 R:R:R274 9.3 3 No Yes 2 3 2 1
R:R:E271 R:R:Y275 13.47 3 No Yes 2 2 2 2
R:R:R274 R:R:Y275 7.2 3 Yes Yes 3 2 1 2
R:R:E278 R:R:K277 10.8 3 No Yes 5 5 1 1
L:L:?1 R:R:A98 3.18 3 Yes No 0 6 0 1
R:R:A153 R:R:F191 2.77 0 No Yes 7 5 2 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.48
Average Nodes In Shell32.00
Average Hubs In Shell11.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9YDU A Nucleotide P2Y P2Y14 Homo Sapiens UDP-Glucose - Gi1/Beta1/Gamma2 3.19 2025-11-19 10.1038/s42003-025-09174-6

A 2D representation of the interactions of UPG in 9YDU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:K77 3.56 2 Yes Yes 0 7 0 1
L:L:?1 R:R:D81 7.54 2 Yes No 0 5 0 1
L:L:?1 R:R:V93 3.01 2 Yes No 0 6 0 1
L:L:?1 R:R:A98 3.18 2 Yes No 0 6 0 1
L:L:?1 R:R:V99 4.52 2 Yes No 0 6 0 1
L:L:?1 R:R:Y102 18.95 2 Yes Yes 0 5 0 1
L:L:?1 R:R:N156 11.1 2 Yes No 0 5 0 1
L:L:?1 R:R:C172 14.43 2 Yes No 0 9 0 1
L:L:?1 R:R:H184 10.39 2 Yes No 0 3 0 1
L:L:?1 R:R:N188 11.1 2 Yes Yes 0 4 0 1
L:L:?1 R:R:F191 3.08 2 Yes Yes 0 5 0 1
L:L:?1 R:R:R253 7.98 2 Yes Yes 0 6 0 1
L:L:?1 R:R:Y256 3.55 2 Yes Yes 0 5 0 1
L:L:?1 R:R:K277 9.26 2 Yes Yes 0 5 0 1
R:R:K77 R:R:Y29 14.33 2 Yes No 7 8 1 2
R:R:D81 R:R:K77 5.53 2 No Yes 5 7 1 1
R:R:E278 R:R:K77 5.4 2 No Yes 5 7 2 1
R:R:D81 R:R:E278 3.9 2 No No 5 5 1 2
R:R:C172 R:R:C94 7.28 0 No No 9 9 1 2
R:R:I157 R:R:V99 7.68 0 No No 5 6 2 1
R:R:Y102 R:R:Y249 4.96 2 Yes Yes 5 7 1 2
R:R:R253 R:R:Y102 7.2 2 Yes Yes 6 5 1 1
R:R:L281 R:R:Y102 4.69 2 No Yes 6 5 2 1
R:R:F191 R:R:Y106 25.79 0 Yes Yes 5 8 1 2
R:R:Y106 R:R:Y249 3.97 2 Yes Yes 8 7 2 2
R:R:F191 R:R:M149 4.98 0 Yes No 5 8 1 2
R:R:F191 R:R:L152 9.74 0 Yes No 5 5 1 2
R:R:N156 R:R:W183 5.65 0 No Yes 5 2 1 2
R:R:N156 R:R:S187 5.96 0 No No 5 4 1 2
R:R:H184 R:R:N188 8.93 2 No Yes 3 4 1 1
R:R:N188 R:R:R253 10.85 2 Yes Yes 4 6 1 1
R:R:N188 R:R:T257 8.77 2 Yes No 4 5 1 2
R:R:R253 R:R:Y249 17.49 2 Yes Yes 6 7 1 2
R:R:L281 R:R:Y249 11.72 2 No Yes 6 7 2 2
R:R:R253 R:R:Y256 8.23 2 Yes Yes 6 5 1 1
R:R:R253 R:R:T257 6.47 2 Yes No 6 5 1 2
R:R:K277 R:R:R253 3.71 2 Yes Yes 5 6 1 1
R:R:S259 R:R:Y256 3.82 2 Yes Yes 3 5 2 1
R:R:Q260 R:R:Y256 16.91 2 No Yes 3 5 2 1
R:R:R274 R:R:Y256 3.09 0 No Yes 3 5 2 1
R:R:K277 R:R:Y256 16.72 2 Yes Yes 5 5 1 1
R:R:Q260 R:R:S259 7.22 2 No Yes 3 3 2 2
R:R:E278 R:R:K277 4.05 2 No Yes 5 5 2 1
R:R:K277 R:R:L281 4.23 2 Yes No 5 6 1 2
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.97
Average Nodes In Shell30.00
Average Hubs In Shell12.00
Average Links In Shell44.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.41
Average Nodes In Shell29.00
Average Hubs In Shell10.50
Average Links In Shell41.25
Average Links Mediated by Hubs In Shell35.75

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)