psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A98	6.5	Yes	No	0	0	6
2	L:L:?1	R:R:V99	8.61	Yes	No	0	0	6
3	L:L:?1	R:R:Y102	27.1	Yes	Yes	2	0	5
4	L:L:?1	R:R:N156	3.4	Yes	No	0	0	5
5	L:L:?1	R:R:C172	2.62	Yes	No	0	0	9
6	L:L:?1	R:R:H184	15.92	Yes	No	2	0	3
7	L:L:?1	R:R:N188	3.4	Yes	No	2	0	4
8	L:L:?1	R:R:F191	5.03	Yes	Yes	0	0	5
9	L:L:?1	R:R:R253	4.01	Yes	Yes	2	0	6
10	L:L:?1	R:R:Y256	5.81	Yes	Yes	2	0	5
11	L:L:?1	R:R:Q260	8.79	Yes	Yes	2	0	3
12	L:L:?1	R:R:R274	5.01	Yes	No	2	0	3
13	R:R:E271	R:R:L18	3.98	No	No	0	2	3
14	R:R:I20	R:R:I25	2.94	No	Yes	6	4	6
15	R:R:I20	R:R:Y275	9.67	No	No	0	4	2
16	R:R:F279	R:R:I20	5.02	No	No	6	5	4
17	R:R:G83	R:R:Q22	3.29	No	No	0	5	4
18	R:R:I24	R:R:L28	2.85	No	No	0	6	5
19	R:R:I25	R:R:P26	3.39	Yes	No	0	6	5
20	R:R:F279	R:R:I25	5.02	No	Yes	6	5	6
21	R:R:I25	R:R:L282	4.28	Yes	No	0	6	5
22	R:R:L28	R:R:L282	8.3	No	No	0	5	5
23	R:R:F74	R:R:Y29	3.09	No	Yes	0	8	8
24	R:R:K77	R:R:Y29	8.36	No	Yes	0	7	8
25	R:R:L282	R:R:Y29	5.86	No	Yes	0	5	8
26	R:R:C30	R:R:I78	4.91	No	No	0	4	7
27	R:R:F33	R:R:I37	6.28	No	No	0	7	7
28	R:R:F33	R:R:F74	10.72	No	No	0	7	8
29	R:R:F33	R:R:P75	10.11	No	No	0	7	9
30	R:R:I34	R:R:L38	2.85	No	No	0	5	4
31	R:R:I37	R:R:S71	3.1	No	No	0	7	6
32	R:R:N40	R:R:S43	5.96	No	No	0	9	8
33	R:R:D67	R:R:N40	4.04	Yes	No	0	9	9
34	R:R:F302	R:R:I46	16.33	Yes	No	0	9	7
35	R:R:F47	R:R:I65	3.77	No	No	0	7	5
36	R:R:P51	R:R:V50	3.53	No	No	0	6	5
37	R:R:I57	R:R:V50	6.14	No	No	0	7	5
38	R:R:F302	R:R:V50	9.18	Yes	No	0	9	5
39	R:R:K54	R:R:V135	3.04	No	No	0	8	3
40	R:R:F56	R:R:S55	6.61	Yes	No	0	8	7
41	R:R:F56	R:R:L60	3.65	Yes	Yes	0	8	8
42	R:R:D118	R:R:F56	4.78	No	Yes	0	8	8
43	R:R:C299	R:R:F56	2.79	No	Yes	0	8	8
44	R:R:I57	R:R:I58	2.94	No	No	0	7	6
45	R:R:F111	R:R:Y59	5.16	Yes	No	0	8	7
46	R:R:L114	R:R:Y59	8.21	No	No	0	7	7
47	R:R:I115	R:R:Y59	6.04	Yes	No	0	9	7
48	R:R:I115	R:R:L60	2.85	Yes	Yes	0	9	8
49	R:R:F296	R:R:L60	8.53	Yes	Yes	1	7	8
50	R:R:F302	R:R:L60	6.09	Yes	Yes	1	9	8
51	R:R:F111	R:R:N62	14.5	Yes	No	1	8	9
52	R:R:N62	R:R:S142	2.98	No	No	1	9	7
53	R:R:N62	R:R:W146	6.78	No	No	1	9	9
54	R:R:D67	R:R:I63	2.8	Yes	Yes	1	9	9
55	R:R:I63	R:R:S108	3.1	Yes	No	1	9	9
56	R:R:F111	R:R:I63	3.77	Yes	Yes	1	8	9
57	R:R:F112	R:R:I63	7.54	Yes	Yes	1	9	9
58	R:R:D291	R:R:I63	2.8	Yes	Yes	1	9	9
59	R:R:F296	R:R:V64	5.24	Yes	No	0	7	9
60	R:R:D67	R:R:M70	2.77	Yes	No	0	9	7
61	R:R:D67	R:R:V288	5.84	Yes	No	0	9	8
62	R:R:D291	R:R:D67	5.32	Yes	Yes	1	9	9
63	R:R:F68	R:R:S71	3.96	No	No	0	7	6
64	R:R:N104	R:R:V69	8.87	No	No	0	8	7
65	R:R:M70	R:R:N104	2.8	No	No	0	7	8
66	R:R:L72	R:R:S71	3	No	No	0	4	6
67	R:R:F74	R:R:T73	2.59	No	No	0	8	7
68	R:R:S97	R:R:T73	3.2	No	No	0	5	7
69	R:R:F101	R:R:T73	5.19	Yes	No	0	7	7
70	R:R:F76	R:R:L89	3.65	Yes	No	4	6	7
71	R:R:F76	R:R:F92	12.86	Yes	Yes	4	6	3
72	R:R:F76	R:R:S97	5.28	Yes	No	4	6	5
73	R:R:D81	R:R:K77	2.77	No	No	0	5	7
74	R:R:L79	R:R:L89	2.77	No	No	0	4	7
75	R:R:L84	R:R:S82	3	No	No	0	3	4
76	R:R:G85	R:R:P86	4.06	No	No	0	4	4
77	R:R:Q88	R:R:W87	27.38	No	No	0	2	9
78	R:R:F92	R:R:L89	3.65	Yes	No	4	3	7
79	R:R:V164	R:R:V91	4.81	No	No	3	2	3
80	R:R:E174	R:R:V91	4.28	Yes	No	3	5	3
81	R:R:F92	R:R:V96	3.93	Yes	No	0	3	4
82	R:R:F92	R:R:S97	3.96	Yes	No	4	3	5
83	R:R:C172	R:R:C94	7.28	No	No	0	9	9
84	R:R:R95	R:R:V96	2.62	No	No	0	8	4
85	R:R:R95	R:R:T160	5.17	No	Yes	3	8	5
86	R:R:N161	R:R:R95	10.85	No	No	3	4	8
87	R:R:L100	R:R:V96	2.98	No	No	0	5	4
88	R:R:I157	R:R:V99	4.61	No	No	0	5	6
89	R:R:F101	R:R:Y102	6.19	Yes	Yes	0	7	5
90	R:R:F101	R:R:L281	7.31	Yes	No	0	7	6
91	R:R:A285	R:R:F101	2.77	No	Yes	0	7	7
92	R:R:Y102	R:R:Y249	4.96	Yes	Yes	2	5	7
93	R:R:R253	R:R:Y102	3.09	Yes	Yes	2	6	5
94	R:R:F246	R:R:M105	3.73	Yes	No	0	9	8
95	R:R:F191	R:R:Y106	27.85	Yes	No	0	5	8
96	R:R:H250	R:R:Y106	4.36	No	No	0	8	8
97	R:R:F111	R:R:V107	2.62	Yes	No	1	8	7
98	R:R:V107	R:R:W146	9.81	No	No	1	7	9
99	R:R:M149	R:R:V107	3.04	No	No	0	8	7
100	R:R:F112	R:R:S108	3.96	Yes	No	1	9	9
101	R:R:F195	R:R:I109	6.28	No	No	0	9	8
102	R:R:I109	R:R:V198	3.07	No	No	0	8	9
103	R:R:F246	R:R:I109	3.77	Yes	No	0	9	8
104	R:R:V110	R:R:V145	4.81	No	No	0	6	7
105	R:R:F111	R:R:S142	5.28	Yes	No	1	8	7
106	R:R:F111	R:R:W146	5.01	Yes	No	1	8	9
107	R:R:D291	R:R:F112	8.36	Yes	Yes	1	9	9
108	R:R:F112	R:R:Y295	16.5	Yes	Yes	1	9	9
109	R:R:G113	R:R:S116	3.71	No	No	0	7	9
110	R:R:I115	R:R:R119	6.26	Yes	No	0	9	9
111	R:R:I115	R:R:Y295	3.63	Yes	Yes	0	9	9
112	R:R:L202	R:R:S116	9.01	No	No	7	8	9
113	R:R:S116	R:R:Y206	3.82	No	Yes	7	9	9
114	R:R:F117	R:R:Y121	10.32	No	Yes	0	6	6
115	R:R:F117	R:R:F205	7.5	No	Yes	0	6	8
116	R:R:R119	R:R:Y206	9.26	No	Yes	0	9	9
117	R:R:Y120	R:R:Y121	8.94	Yes	Yes	5	8	6
118	R:R:V124	R:R:Y120	3.79	Yes	Yes	5	8	8
119	R:R:P126	R:R:Y120	9.74	No	Yes	5	7	8
120	R:R:F205	R:R:Y120	7.22	Yes	Yes	0	8	8
121	R:R:A208	R:R:Y120	2.67	No	Yes	0	4	8
122	R:R:I209	R:R:Y120	4.84	No	Yes	0	8	8
123	R:R:P126	R:R:Y121	2.78	No	Yes	5	7	6
124	R:R:L127	R:R:Y121	5.86	No	Yes	0	6	6
125	R:R:W128	R:R:Y121	14.47	No	Yes	0	4	6
126	R:R:F131	R:R:Y121	6.19	No	Yes	0	4	6
127	R:R:P126	R:R:V124	8.84	No	Yes	5	7	8
128	R:R:K212	R:R:V124	3.04	No	Yes	0	5	8
129	R:R:K125	R:R:W128	4.64	No	No	0	6	4
130	R:R:F131	R:R:S134	2.64	No	No	0	4	7
131	R:R:I144	R:R:L140	5.71	No	No	0	2	3
132	R:R:L151	R:R:M147	2.83	No	No	0	4	4
133	R:R:F191	R:R:M149	4.98	Yes	No	0	5	8
134	R:R:I190	R:R:L152	4.28	No	No	0	5	5
135	R:R:P155	R:R:V154	3.53	No	No	0	7	5
136	R:R:P155	R:R:W183	14.86	No	No	0	7	2
137	R:R:N156	R:R:T160	2.92	No	Yes	0	5	5
138	R:R:N156	R:R:W183	7.91	No	No	0	5	2
139	R:R:I157	R:R:I158	5.89	No	No	0	5	4
140	R:R:L159	R:R:Q162	2.66	No	No	8	5	5
141	R:R:L159	R:R:L179	12.46	No	No	8	5	2
142	R:R:N161	R:R:T160	11.7	No	Yes	3	4	5
143	R:R:L175	R:R:T160	5.9	No	Yes	0	5	5
144	R:R:E174	R:R:N161	11.83	Yes	No	3	5	4
145	R:R:L179	R:R:Q162	2.66	No	No	8	2	5
146	R:R:K176	R:R:S163	6.12	No	No	0	4	2
147	R:R:E174	R:R:V164	8.56	Yes	No	3	5	2
148	R:R:E174	R:R:R165	3.49	Yes	No	0	5	2
149	R:R:K176	R:R:R165	6.19	No	No	0	4	2
150	R:R:T168	R:R:V167	4.76	No	No	0	3	2
151	R:R:I173	R:R:R181	7.52	No	No	0	4	2
152	R:R:I173	R:R:Q260	6.86	No	Yes	0	4	3
153	R:R:G180	R:R:L175	5.13	No	No	0	3	5
154	R:R:E178	R:R:S177	10.06	No	No	0	2	3
155	R:R:E178	R:R:K182	9.45	No	No	0	2	1
156	R:R:H184	R:R:Q260	3.71	No	Yes	2	3	3
157	R:R:K185	R:R:Y189	10.75	No	No	0	3	4
158	R:R:K185	R:R:T261	7.51	No	No	0	3	1
159	R:R:F191	R:R:S187	2.64	Yes	No	0	5	4
160	R:R:N188	R:R:R253	13.26	No	Yes	2	4	6
161	R:R:N188	R:R:T257	7.31	No	No	2	4	5
162	R:R:I254	R:R:Y189	3.63	No	No	0	5	4
163	R:R:I254	R:R:V192	4.61	No	No	0	5	5
164	R:R:F195	R:R:W196	6.01	No	No	0	9	4
165	R:R:F195	R:R:H250	27.15	No	No	0	9	8
166	R:R:F199	R:R:W196	3.01	No	No	0	7	4
167	R:R:F199	R:R:F242	6.43	No	No	0	7	9
168	R:R:F199	R:R:F243	3.22	No	No	0	7	7
169	R:R:F205	R:R:L201	10.96	Yes	No	0	8	7
170	R:R:L202	R:R:Y206	4.69	No	Yes	7	8	9
171	R:R:I235	R:R:Y206	4.84	No	Yes	0	8	9
172	R:R:F214	R:R:T210	3.89	No	No	0	4	5
173	R:R:I235	R:R:T210	6.08	No	No	0	8	5
174	R:R:F214	R:R:S232	3.96	No	No	0	4	6
175	R:R:L218	R:R:S216	9.01	No	No	0	2	5
176	R:R:L218	R:R:S224	10.51	No	No	0	2	4
177	R:R:K228	R:R:L218	8.46	No	No	0	6	2
178	R:R:K219	R:R:S220	7.65	No	No	0	3	4
179	R:R:N223	R:R:S221	4.47	No	No	0	1	3
180	R:R:N223	R:R:R222	3.62	No	No	0	1	2
181	R:R:K229	R:R:T225	4.5	No	No	0	5	3
182	R:R:K230	R:R:S226	4.59	No	No	0	7	4
183	R:R:F236	R:R:S232	2.64	No	No	0	5	6
184	R:R:L298	R:R:N234	8.24	No	No	0	7	8
185	R:R:I238	R:R:Y295	4.84	No	Yes	0	8	9
186	R:R:F240	R:R:V241	2.62	No	No	0	5	7
187	R:R:F240	R:R:V244	6.55	No	No	0	5	6
188	R:R:I294	R:R:V241	4.61	No	No	0	8	7
189	R:R:F243	R:R:V247	15.73	No	No	0	7	5
190	R:R:C245	R:R:N287	12.6	No	No	0	9	9
191	R:R:F246	R:R:S284	7.93	Yes	No	0	9	8
192	R:R:F246	R:R:N287	7.25	Yes	No	0	9	9
193	R:R:P248	R:R:V247	3.53	No	No	0	9	5
194	R:R:I251	R:R:V247	3.07	No	No	0	5	5
195	R:R:P248	R:R:T280	3.5	No	No	0	9	7
196	R:R:H250	R:R:Y249	13.07	No	Yes	0	8	7
197	R:R:R253	R:R:Y249	14.4	Yes	Yes	2	6	7
198	R:R:T280	R:R:Y249	4.99	No	Yes	0	7	7
199	R:R:L281	R:R:Y249	7.03	No	Yes	0	6	7
200	R:R:R253	R:R:Y256	7.2	Yes	Yes	2	6	5
201	R:R:R253	R:R:T257	3.88	Yes	No	2	6	5
202	R:R:K277	R:R:R253	4.95	No	Yes	2	5	6
203	R:R:I254	R:R:P255	3.39	No	No	0	5	5
204	R:R:Q260	R:R:Y256	6.76	Yes	Yes	2	3	5
205	R:R:R274	R:R:Y256	4.12	No	Yes	2	3	5
206	R:R:K277	R:R:Y256	17.91	No	Yes	2	5	5
207	R:R:L273	R:R:S259	6.01	No	No	0	4	3
208	R:R:E262	R:R:T261	12.7	No	No	0	1	1
209	R:R:E262	R:R:H264	7.39	No	No	0	1	1
210	R:R:A263	R:R:K270	3.21	No	No	0	1	3
211	R:R:S269	R:R:Y265	19.08	No	No	0	1	1
212	R:R:C267	R:R:Q268	7.63	No	No	0	8	2
213	R:R:E271	R:R:Y275	10.1	No	No	0	2	2
214	R:R:K277	R:R:L281	2.82	No	No	0	5	6
215	R:R:C289	R:R:L290	3.17	No	No	0	8	7
216	R:R:D291	R:R:P292	3.22	Yes	No	0	9	9
217	R:R:D291	R:R:Y295	5.75	Yes	Yes	1	9	9
218	R:R:D291	R:R:F296	5.97	Yes	Yes	1	9	7
219	R:R:I294	R:R:Y295	3.63	No	Yes	0	8	9
220	R:R:F296	R:R:F302	3.22	Yes	Yes	1	7	9
221	R:R:C299	R:R:F302	9.78	No	Yes	0	8	9
222	R:R:P301	R:R:Q300	3.16	No	No	0	6	5
223	R:R:Q300	R:R:R303	12.85	No	No	0	5	8
224	R:R:E304	R:R:Q300	3.82	No	No	0	5	5
225	R:R:S136	R:R:Y137	2.54	No	No	0	4	3
226	R:R:V239	R:R:Y206	2.52	No	Yes	0	8	9
227	R:R:T257	R:R:Y189	2.5	No	No	0	5	4
228	R:R:I78	R:R:Y29	2.42	No	Yes	0	7	8
229	R:R:I209	R:R:Y206	2.42	No	Yes	0	8	9
230	R:R:L140	R:R:Y137	2.34	No	No	0	3	3
231	R:R:E166	R:R:R165	2.33	No	No	0	2	2
232	R:R:E304	R:R:Y49	2.24	No	No	0	5	5
233	R:R:F47	R:R:F48	2.14	No	No	0	7	4
234	R:R:A35	R:R:G36	1.95	No	No	0	5	8
235	R:R:C299	R:R:P301	1.88	No	No	0	8	6
236	R:R:G44	R:R:S43	1.86	No	No	0	7	8
237	R:R:G83	R:R:S82	1.86	No	No	0	5	4
238	R:R:A35	R:R:C289	1.81	No	No	0	5	8
239	R:R:G80	R:R:L79	1.71	No	No	0	5	4
240	R:R:G85	R:R:L84	1.71	No	No	0	4	3
241	R:R:A286	R:R:V32	1.7	No	No	0	4	7
242	R:R:G80	R:R:N90	1.7	No	No	0	5	7
243	R:R:A153	R:R:V99	1.7	No	No	0	7	6
244	R:R:A153	R:R:V103	1.7	No	No	0	7	6
245	R:R:L39	R:R:P292	1.64	No	No	0	8	9
246	R:R:L159	R:R:P155	1.64	No	No	0	5	7
247	R:R:L273	R:R:P255	1.64	No	No	0	4	5
248	R:R:S53	R:R:S55	1.63	No	No	0	5	7
249	R:R:S221	R:R:S224	1.63	No	No	0	3	4
250	R:R:S231	R:R:V227	1.62	No	No	0	8	5
251	R:R:S237	R:R:V241	1.62	No	No	0	6	7
252	R:R:A252	R:R:M276	1.61	No	No	0	5	5
253	R:R:C289	R:R:L39	1.59	No	No	0	8	8
254	R:R:P86	R:R:Q88	1.58	No	No	0	4	2
255	R:R:I213	R:R:S231	1.55	No	No	0	8	8
256	R:R:I65	R:R:V69	1.54	No	No	0	5	7
257	R:R:I194	R:R:V110	1.54	No	No	0	6	6
258	R:R:I123	R:R:V124	1.54	No	Yes	0	8	8
259	R:R:I203	R:R:V204	1.54	No	No	0	4	4
260	R:R:K139	R:R:S138	1.53	No	No	0	5	8
261	R:R:K176	R:R:S177	1.53	No	No	0	4	3
262	R:R:K270	R:R:S259	1.53	No	No	0	3	3
263	R:R:M149	R:R:V110	1.52	No	No	0	8	6
264	R:R:I203	R:R:T207	1.52	No	No	0	4	4
265	R:R:L150	R:R:V103	1.49	No	No	0	3	6
266	R:R:L150	R:R:V154	1.49	No	No	0	3	5
267	R:R:I123	R:R:I213	1.47	No	No	0	8	8
268	R:R:I190	R:R:I194	1.47	No	No	0	5	6
269	R:R:I209	R:R:I213	1.47	No	No	0	8	8
270	R:R:I46	R:R:K61	1.45	No	No	0	7	6
271	R:R:I58	R:R:K61	1.45	No	No	0	6	6
272	R:R:I173	R:R:K171	1.45	No	No	0	4	3
273	R:R:Q268	R:R:S266	1.44	No	No	0	2	5
274	R:R:Q88	R:R:V91	1.43	No	No	0	2	3
275	R:R:E166	R:R:V167	1.43	No	No	0	2	2
276	R:R:I203	R:R:L200	1.43	No	No	0	4	3
277	R:R:I272	R:R:L273	1.43	No	No	0	1	4
278	R:R:I293	R:R:L290	1.43	No	No	0	7	7
279	R:R:Q22	R:R:T21	1.42	No	No	0	4	4
280	R:R:L148	R:R:M147	1.41	No	No	0	4	4
281	R:R:L18	R:R:L19	1.38	No	No	0	3	3
282	R:R:I24	R:R:Q23	1.37	No	No	0	6	3
283	R:R:E278	R:R:I25	1.37	No	Yes	0	5	6
284	R:R:F76	R:R:V93	1.31	Yes	No	0	6	6
285	R:R:F205	R:R:V204	1.31	Yes	No	0	8	4
286	R:R:E166	R:R:Q169	1.27	No	No	0	2	1
287	R:R:E271	R:R:Q268	1.27	No	No	0	2	2
288	R:R:V32	R:R:Y29	1.26	No	Yes	0	7	8
289	R:R:F214	R:R:K228	1.24	No	No	0	4	6
290	R:R:K229	R:R:R233	1.24	No	No	0	5	5
291	R:R:N234	R:R:R233	1.21	No	No	0	8	5
292	R:R:F297	R:R:R303	1.07	No	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.01667	12	2	0
2	R:R:I25	3.4	5	6	6
3	R:R:Y29	4.198	5	0	8
4	R:R:F56	4.4575	4	0	8
5	R:R:L60	5.28	4	1	8
6	R:R:I63	4.002	5	1	9
7	R:R:D67	4.154	5	1	9
8	R:R:F76	5.775	4	4	6
9	R:R:F92	6.1	4	4	3
10	R:R:F101	5.365	4	0	7
11	R:R:Y102	10.335	4	2	5
12	R:R:F111	6.05667	6	1	8
13	R:R:F112	9.09	4	1	9
14	R:R:I115	4.695	4	0	9
15	R:R:Y120	6.2	6	5	8
16	R:R:Y121	8.09333	6	5	6
17	R:R:V124	4.3025	4	5	8
18	R:R:T160	6.4225	4	3	5
19	R:R:E174	7.04	4	3	5
20	R:R:F191	10.125	4	0	5
21	R:R:F205	6.7475	4	0	8
22	R:R:Y206	4.59167	6	7	9
23	R:R:F246	5.67	4	0	9
24	R:R:Y249	8.89	5	2	7
25	R:R:R253	7.25571	7	2	6
26	R:R:Y256	8.36	5	2	5
27	R:R:Q260	6.53	4	2	3
28	R:R:D291	5.23667	6	1	9
29	R:R:Y295	6.87	5	1	9
30	R:R:F296	5.74	4	1	7
31	R:R:F302	8.92	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y102	40.3389	27.1	Yes	Yes	2	0	5
2	R:R:F101	R:R:Y102	38.9625	6.19	Yes	Yes	0	7	5
3	R:R:F101	R:R:T73	40.6327	5.19	Yes	No	0	7	7
4	R:R:F74	R:R:T73	33.5051	2.59	No	No	0	8	7
5	R:R:F74	R:R:Y29	26.3211	3.09	No	Yes	0	8	8
6	R:R:L282	R:R:Y29	18.7387	5.86	No	Yes	0	5	8
7	R:R:I25	R:R:L282	14.219	4.28	Yes	No	0	6	5
8	L:L:?1	R:R:N156	40.685	3.4	Yes	No	0	0	5
9	R:R:N156	R:R:T160	34.0363	2.92	No	Yes	0	5	5
10	R:R:N161	R:R:T160	24.188	11.7	No	Yes	3	4	5
11	R:R:E174	R:R:N161	26.9409	11.83	Yes	No	3	5	4
12	R:R:E174	R:R:V91	12.6534	4.28	Yes	No	3	5	3
13	R:R:Q88	R:R:V91	11.5145	1.43	No	No	0	2	3
14	L:L:?1	R:R:F191	91.4638	5.03	Yes	Yes	0	0	5
15	R:R:F191	R:R:M149	100	4.98	Yes	No	0	5	8
16	R:R:M149	R:R:V107	99.2031	3.04	No	No	0	8	7
17	R:R:F111	R:R:V107	97.5852	2.62	Yes	No	1	8	7
18	R:R:F111	R:R:I63	39.5943	3.77	Yes	Yes	1	8	9
19	R:R:F111	R:R:Y59	58.6389	5.16	Yes	No	0	8	7
20	R:R:I115	R:R:Y59	57.6891	6.04	Yes	No	0	9	7
21	R:R:I115	R:R:L60	26.0434	2.85	Yes	Yes	0	9	8
22	R:R:F302	R:R:L60	14.4323	6.09	Yes	Yes	1	9	8
23	R:R:D291	R:R:I63	24.2001	2.8	Yes	Yes	1	9	9
24	R:R:D291	R:R:F296	15.1004	5.97	Yes	Yes	1	9	7
25	R:R:F296	R:R:F302	13.0358	3.22	Yes	Yes	1	7	9
26	R:R:F56	R:R:L60	11.0516	3.65	Yes	Yes	0	8	8
27	R:R:C299	R:R:F302	13.1122	9.78	No	Yes	0	8	9
28	R:R:S97	R:R:T73	16.3601	3.2	No	No	0	5	7
29	R:R:R95	R:R:V96	10.0455	2.62	No	No	0	8	4
30	R:R:Y102	R:R:Y249	11.1362	4.96	Yes	Yes	2	5	7
31	L:L:?1	R:R:R253	20.9844	4.01	Yes	Yes	2	0	6
32	R:R:H250	R:R:Y249	14.9314	13.07	No	Yes	0	8	7
33	R:R:F195	R:R:H250	19.4752	27.15	No	No	0	9	8
34	R:R:F195	R:R:I109	12.2228	6.28	No	No	0	9	8
35	R:R:F191	R:R:Y106	14.8066	27.85	Yes	No	0	5	8
36	R:R:H250	R:R:Y106	14.1828	4.36	No	No	0	8	8
37	R:R:I115	R:R:Y295	11.2851	3.63	Yes	Yes	0	9	9
38	R:R:I115	R:R:R119	41.5221	6.26	Yes	No	0	9	9
39	R:R:R119	R:R:Y206	40.6769	9.26	No	Yes	0	9	9
40	R:R:I209	R:R:Y206	25.4316	2.42	No	Yes	0	8	9
41	R:R:I209	R:R:Y120	20.4652	4.84	No	Yes	0	8	8
42	R:R:E174	R:R:R165	12.7541	3.49	Yes	No	0	5	2
43	L:L:?1	R:R:N188	12.1584	3.4	Yes	No	2	0	4
44	R:R:N188	R:R:T257	11.2649	7.31	No	No	2	4	5
45	R:R:T257	R:R:Y189	24.8481	2.5	No	No	0	5	4
46	R:R:R253	R:R:T257	15.4345	3.88	Yes	No	2	6	5
47	R:R:I254	R:R:Y189	15.4506	3.63	No	No	0	5	4
48	R:R:T280	R:R:Y249	11.6755	4.99	No	Yes	0	7	7
49	R:R:I235	R:R:Y206	13.2048	4.84	No	Yes	0	8	9
50	R:R:I235	R:R:T210	12.1987	6.08	No	No	0	8	5
51	R:R:F214	R:R:T210	11.1241	3.89	No	No	0	4	5
52	R:R:I294	R:R:Y295	13.398	3.63	No	Yes	0	8	9
53	R:R:I294	R:R:V241	10.7337	4.61	No	No	0	8	7
54	R:R:I254	R:R:P255	11.6352	3.39	No	No	0	5	5
55	R:R:C299	R:R:P301	16.9719	1.88	No	No	0	8	6
56	R:R:P301	R:R:Q300	14.1627	3.16	No	No	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A98	6.5	2	Yes	No	0	6	0	1
L:L:?1	R:R:V99	8.61	2	Yes	No	0	6	0	1
L:L:?1	R:R:Y102	27.1	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:N156	3.4	2	Yes	No	0	5	0	1
L:L:?1	R:R:C172	2.62	2	Yes	No	0	9	0	1
L:L:?1	R:R:H184	15.92	2	Yes	No	0	3	0	1
L:L:?1	R:R:N188	3.4	2	Yes	No	0	4	0	1
L:L:?1	R:R:F191	5.03	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:R253	4.01	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y256	5.81	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Q260	8.79	2	Yes	Yes	0	3	0	1
L:L:?1	R:R:R274	5.01	2	Yes	No	0	3	0	1
R:R:C172	R:R:C94	7.28	0	No	No	9	9	1	2
R:R:I157	R:R:V99	4.61	0	No	No	5	6	2	1
R:R:F101	R:R:Y102	6.19	0	Yes	Yes	7	5	2	1
R:R:Y102	R:R:Y249	4.96	2	Yes	Yes	5	7	1	2
R:R:R253	R:R:Y102	3.09	2	Yes	Yes	6	5	1	1
R:R:F191	R:R:Y106	27.85	0	Yes	No	5	8	1	2
R:R:F191	R:R:M149	4.98	0	Yes	No	5	8	1	2
R:R:N156	R:R:T160	2.92	0	No	Yes	5	5	1	2
R:R:N156	R:R:W183	7.91	0	No	No	5	2	1	2
R:R:I173	R:R:Q260	6.86	0	No	Yes	4	3	2	1
R:R:H184	R:R:Q260	3.71	2	No	Yes	3	3	1	1
R:R:F191	R:R:S187	2.64	0	Yes	No	5	4	1	2
R:R:N188	R:R:R253	13.26	2	No	Yes	4	6	1	1
R:R:N188	R:R:T257	7.31	2	No	No	4	5	1	2
R:R:R253	R:R:Y249	14.4	2	Yes	Yes	6	7	1	2
R:R:R253	R:R:Y256	7.2	2	Yes	Yes	6	5	1	1
R:R:R253	R:R:T257	3.88	2	Yes	No	6	5	1	2
R:R:K277	R:R:R253	4.95	2	No	Yes	5	6	2	1
R:R:Q260	R:R:Y256	6.76	2	Yes	Yes	3	5	1	1
R:R:R274	R:R:Y256	4.12	2	No	Yes	3	5	1	1
R:R:K277	R:R:Y256	17.91	2	No	Yes	5	5	2	1
R:R:A153	R:R:V99	1.7	0	No	No	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9YDV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.59
Number of Linked Nodes	265
Number of Links	292
Number of Hubs	31
Number of Links mediated by Hubs	123
Number of Communities	8
Number of Nodes involved in Communities	48
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	44616
Length Of Smallest Path	3
Average Path Length	13.1711
Length of Longest Path	31
Minimum Path Strength	1.225
Average Path Strength	5.77611
Maximum Path Strength	20.11
Minimum Path Correlation	0.7
Average Path Correlation	0.93251
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	53.163
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.2573
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • multicellular organismal process • multicellular organismal-level homeostasis • homeostatic process • hematopoietic stem cell homeostasis • homeostasis of number of cells • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q15391
Sequence	>9YDV_nogp_Chain_R L L I T Q Q I I P V L Y C M V F I A G I L L N G V S G W I F F Y V P S S K S F I I Y L K N I V I A D F V M S L T F P F K I L G D S G L G P W Q L N V F V C R V S A V L F Y V N M Y V S I V F F G L I S F D R Y Y K I V K P L W T S F I Q S V S Y S K L L S V I V W M L M L L L A V P N I I L T N Q S V R E V T Q I K C I E L K S E L G R K W H K A S N Y I F V A I F W I V F L L L I V F Y T A I T K K I F K S H L K S S R N S T S V K K K S S R N I F S I V F V F F V C F V P Y H I A R I P Y T K S Q T E A H Y S C Q S K E I L R Y M K E F T L L L S A A N V C L D P I I Y F F L C Q P F R E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9J0F	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	NADH	-	Gi1/β1/γ2	2.76	2025-06-04	doi.org/10.1038/s41421-025-00799-9
	9J0F (No Gprot)	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	NADH	-		2.76	2025-06-04	doi.org/10.1038/s41421-025-00799-9
	9J0I	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	UDP-Glucuronic acid	-	Gi1/β1/γ2	2.76	2025-06-04	doi.org/10.1038/s41421-025-00799-9
	9J0I (No Gprot)	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	UDP-Glucuronic acid	-		2.76	2025-06-04	doi.org/10.1038/s41421-025-00799-9
	9J0B	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	UDP-Glucose	-	Gi1/β1/γ2	2.88	2025-06-04	10.1038/s41421-025-00799-9
	9J0B (No Gprot)	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	UDP-Glucose	-		2.88	2025-06-04	10.1038/s41421-025-00799-9
	9J05	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	-	-	-	3.2	2025-08-06	To be published
	9YDU	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	UDP-Glucose	-	Gi1/β1/γ2	3.19	2025-11-19	10.1038/s42003-025-09174-6
	9YDU (No Gprot)	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	UDP-Glucose	-		3.19	2025-11-19	10.1038/s42003-025-09174-6
	9YDV	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	MRS2905	-	Gi1/β1/γ2	3.05	2025-11-19	10.1038/s42003-025-09174-6
	9YDV (No Gprot)	A	Nucleotide	P2Y	P2Y₁₄	Homo sapiens	MRS2905	-		3.05	2025-11-19	10.1038/s42003-025-09174-6

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